Inflam Cancer Research Results

Inflam, inflammation: Click to Expand ⟱
Source:
Type:
Cancer and inflammation are closely linked, with chronic inflammation contributing to the development and progression of cancer. Various inflammatory mediators and cells are involved in this process.
Scientific Papers found: Click to Expand⟱
4016- FulvicA,    Shilajit: A Natural Phytocomplex with Potential Procognitive Activity
- Review, AD, NA
*tau↓, *AntiAge↑, *Strength↑, *Dose↝, *BioAv↑, *antiOx↑, *memory↑, *Inflam↓, *cognitive↑, *neuroP↑, *toxicity↝, *toxicity↑,
4018- FulvicA,  Fe,    Inhibitory Impacts of Fulvic Acid-Coated Iron Oxide Nanoparticles on the Amyloid Fibril Aggregations
- in-vivo, AD, NA
*Inflam↓, *Aβ↓,
4024- FulvicA,    ANTI-CARCINOGENIC ACTIVITY OF SHILAJIT REGARDING TO APOPTOSIS ASSAY IN CANCER CELLS: A SYSTEMATIC REVIEW OF IN-VITRO STUDIES
- Review, Var, NA
*Inflam↓, *antiOx↑, TumCG↓, tumCV↓, ROS↑, ChemoSen↑, toxicity↝,
4026- FulvicA,    Shilajitin Cancer Treatment: Probable Mode of Action
- Review, Var, NA
*Inflam↓, *antiOx↑, Dose↝,
1773- GA,    Impact of Gallic Acid on Gut Health: Focus on the Gut Microbiome, Immune Response, and Mechanisms of Action
- Review, Var, NA
antiOx↑, AntiCan↑, Inflam↓, GutMicro↑, CompStab↝, BioAv↓, BioAv↑, TumMeta↓,
7035- GA,    Gallic acid attenuates LPS-induced inflammation in Caco-2 cells by suppressing the activation of the NF-κB/MAPK signaling pathway
- in-vitro, IBD, Caco-2
*Inflam↓, *antiOx↑, *CLDN1↓, *OCLN↓, *ZO-1↓, *IL6↓, *IL1β↓, *TNF-α↓, *BAX↓, *BAD↓, *Casp3↓, *Casp8↓, *ROS↓, *SOD↑, *Catalase↑, *GSH↑, *TJ↑, *Apoptosis↓, *NF-kB↓, *MAPK↓,
7042- GA,    Gallic acid reduces cell growth by induction of apoptosis and reduction of IL-8 in HepG2 cells
- in-vitro, Liver, HepG2
*Inflam↓, *AntiTum↑, *antiOx↑, TumCP↓, IL8↓, IL10↑, IL12↑, Apoptosis↑,
7049- GA,    Pharmacological effects of gallic acid in health and diseases: A mechanistic review
- Review, Var, NA
*antiOx↑, *Inflam↓, *antiNeop↑, *cardioP↑, *Bacteria↓, *AST↓, *ALAT↓, *ALP↓, *lipid-P↓, *GSH↑, *Catalase↑, *GPx↑, *GSTs↑, *Urea↓, *creat↓, tumCV↓, TumCCA↑, i-Ca+2↑, CDK1↑, Casp3↑, Casp8↑, Casp9↑, MMP↓, ROS↑, MMPs↓, *GastroP↑, *hepatoP↑, *ROS↓, *AChE↓,
7028- GA,    Gallic acid: Pharmacological activities and molecular mechanisms involved in inflammation-related diseases
- Review, Nor, NA
*toxicity↓, *Inflam↓, *NF-kB↓, AntiTum↑, Bacteria↓, *AntiDiabetic↑, *Obesity↓, *AntiBio↑, *Stroke↓, *NO↓, *PGE2↓, *IL6↓, *MAPK↓, *TNF-α↓, *IL1β↓, *MCP1/CCL2↓, *ICAM-1↓, *TIMP1↓,
7027- GA,    Pharmacokinetics of gallic acid and its relative bioavailability from tea in healthy humans
- Human, Nor, NA
AntiCan↑, *Inflam↓, *BioAv↑, *Half-Life↓, *eff↝,
7069- GABA,    United States Pharmacopeia (USP) Safety Review of Gamma-Aminobutyric Acid (GABA)
- Review, Nor, NA
*toxicity↓, *BP↓, *AntiDiabetic↑, *AntiCan↑, *antiOx↑, *Inflam↓, *AntiBio↑, *other↝, *cognitive↑, *GH↑, *Sleep↑, *BioAv↑, *Half-Life↝, *BBB↓, *Synergy↑,
7080- GABA,    The Effect of Oral GABA on the Nervous System: Potential for Therapeutic Intervention
- Review, AD, NA
*BBB↝, *cognitive↑, *Dose↝, *toxicity↓, *Stress↓, *Inflam↓, *iNOS↓, *COX2/PTGS2↓, *IL6↓, *IL1β↓, *TNF-α↓, *Sleep↑, *Pain↓, *neuroP↑, *eff↑, *Ach↑, *AST↓, *ALAT↓, *BP↓, *other↝,
7082- GABA,    Contributions of Gamma-Aminobutyric Acid (GABA) Produced by Lactic Acid Bacteria on Food Quality and Human Health: Current Applications and Future Prospects
- Review, AD, NA
*neuroP↑, *Sleep↑, *Pain↓, *Inflam↓, *BP↓, *cognitive↑, *memory↑, *eff↑, *AChE↓, *Wound Healing↑,
7052- Gallo,    Galloflavin Relieves the Malignant Behavior of Colorectal Cancer Cells in the Inflammatory Tumor Microenvironment
- in-vivo, Colon, SW48
TumCMig↓, TumCI↓, NLRP3↓, LDH↓, Inflam↓, IL6↓, TNF-α↓, IL1β↓,
7066- GamB,    Unravelling the Therapeutic Potential of Gambogic Acid: Deciphering Its Molecular Mechanism of Action and Emerging Role as an Anticancer Xanthone
- Review, Var, NA
angioG↓, TumMeta↓, ChemoSen↑, *cardioP↑, *Inflam↓, *AntiViral↑, *antiOx↑, NF-kB↓, TNF-α↓, COX2/PTGS2↓, iNOS↓, Apoptosis↑, TumAuto↑, TumCP↓, TumCI↓, BioAv↓, ROS↑, MMP↓, SIRT1↓, Akt↓, mTORC1↓, AMPK↑, LRIG1↑, ER Stress↑, Paraptosis↑, Ferroptosis↑, HSP90↓, GSH↓, lipid-P↑, GPx4↓, miR-21↓, PI3K↓, Akt↓, PTEN↑, ASAP2↓, CDK7↓,
7087- GAR,    Garcinol as an Epigenetic Modulator: Mechanisms of Anti-Cancer Activity and Therapeutic Potential
- Review, Var, NA
HATs↓, p300↓, CBP↓, NF-kB↓, STAT3↓, PI3K↓, Akt↓, MAPK↓, Wnt↓, β-catenin/ZEB1↓, Inflam↓, angioG↓, TumCP↓, TumMeta↓, TumCCA↑, EMT↓, CSCs↓, P53↑, TrxR↓, ROS↑, JNK↑, DNAdam↑, mt-Apoptosis↑, ER Stress↑, CHOP/DDIT3↑, DDIT4↑, TRIB3↑, SESN2↑, miR-218↑, eff↑, ChemoSen↑, BioAv↓, Half-Life↓, BioAv↑,
7084- GAR,    A unique in vivo pharmacokinetic profile, in vitro metabolic stability and hepatic first-pass metabolism of garcinol, a promising novel anticancer phytoconstituent, by liquid chromatography–mass spectrometry
- in-vivo, Nor, NA
*BioAv↝, *Dose↝, *Inflam↓, *antiOx↑, *chemoPv↑, Wnt↓, β-catenin/ZEB1↓, ERK↓, PI3K↓, Akt↓, NF-kB↓, STAT3↓, TumCP↓, antiNeop↑, ChemoSen↑, chemoP↑,
7090- GAR,    Garcinol
- in-vitro, Var, NA
AChE↓, BChE↓, *Inflam↓, *5LO↓, *PGE2↓, *antiOx↑, FAK↓, DNAdam↑, MMP↓, Casp↑, NF-kB↓, HATs↓, *toxicity↓,
7091- GAR,    Garcinol-A Natural Histone Acetyltransferase Inhibitor and New Anti-Cancer Epigenetic Drug
- Review, Var, NA
antiOx↑, Inflam↓, HATs↓, p300↓, CBP↓, PCAF↓, cycD1/CCND1↓, STAT↓, PI3K↓, Akt↓, TumCP↓, TumCI↓, TumMeta↓, TumCCA↑, CDK2↓, CDK4↓,
7092- GAR,    Garcinol and Its Role in Chronic Diseases
- Review, Var, NA
antiOx↑, Inflam↓, AntiCan↑, NF-kB↓, STAT3↓, antiNeop↑, 5LO↓, Synergy↑, HATs↓, p300↓, PCAF↓, miR-200c↑, NOTCH1↓, CSCs↓, COX2/PTGS2↓, cycD1/CCND1↓, VEGF↓, PI3K↓, Akt↓, Wnt↑, β-catenin/ZEB1↓, ROS↑, CHOP/DDIT3↑, Bax:Bcl2↑, Casp8↑, FAK↓, *neuroP↑, PCNA↓, *GSTs↑,
7093- GAR,    Garcinol
- Review, AD, NA
*AChE↓, *BChE↓, *HATs↓, *Inflam↓, AntiCan↑,
7204- GAs,    The Pharmacology and Toxicology of Ginkgolic Acids: Secondary Metabolites from Ginkgo biloba
- Review, Nor, NA
AntiTum↑, SUMO↓, antiNeop↑, *Inflam↓, *Bacteria↓, *AntiViral↑, *toxicity↑, *ROS↑, *toxicity↝,
7205- GBE,    Exploring the multifaceted role of ginkgolides and bilobalide from Ginkgo biloba in mitigating metabolic disorders
- Review, AD, NA
*antiOx↑, *Inflam↓, *neuroP↑, *ROS↓, *cardioP↑, *Obesity↓, *BioAv↓,
7206- GBE,  EGb 761,    Ginkgo biloba: A Leaf of Hope in the Fight against Alzheimer's Dementia: Clinical Trial Systematic Review
- Review, AD, NA
*Dose↝, *Inflam↓, *antiOx↑, *neuroP↑, *cognitive↑,
7207- GBE,    The molecular mechanisms of ginkgo (Ginkgo biloba) activity in signaling pathways: A comprehensive review
- Review, AD, NA
*Inflam↓, *Apoptosis↓, *neuroP↑, *cardioP↑, *hepatoP↑, *AntiViral↑, *Bacteria↓, *RenoP↑, *ROS↓, *NADPH↓, *MAPK↓, *ERK↓, *JNK↓, *AP-1↓, *cAMP↑, *STAT5↓, *AMPK↑,
1189- GBE,    New insight into the mechanisms of Ginkgo biloba leaves in the treatment of cancer
- Review, Var, NA
Apoptosis↑, TumCP↓, TumCI↓, TumCMig↓, Inflam↓, antiOx↑, angioG↓,
7670- GCL2505,    Effect of Continuous Ingestion of Bifidobacteria and Dietary Fiber on Improvement in Cognitive Function: A Randomized, Double-Blind, Placebo-Controlled Trial
- Trial, AD, NA
*cognitive↑, *GutMicro↑, *Inflam↓, *Dose↝, *BDNF∅,
7126- Ge-132,    Immune activation of Bio-Germanium in a randomized, double-blind, placebo-controlled clinical trial with 130 human subjects: Therapeutic opportunities from new insights
- Trial, Nor, NA
AntiTum↑, AntiCan↑, *AntiAge↑, *AntiViral↑, *Inflam↓, *NK cell↑, *Imm↑, *TNF-α↑,
7124- Ge-132,    Physiological Activity of Trace Element Germanium including Anticancer Properties
- Review, Var, NA
*toxicity↓, Risk↓, Dose↝, AntiCan↑, AntiTum↑, Inflam↓, OXPHOS↝, *toxicity↓, *toxicity↓, other↑, Synergy↑, *Bacteria↓, *AntiFungal↑, eff↑, Synergy↑, ROS↑, Synergy↑, toxicity↝, *H2O2↓, *ROS↓, Warburg↓,
7108- GEN,    Genistein: A Review on its Anti-Inflammatory Properties
- Review, Nor, NA
*cardioP↑, *Inflam↓, *NF-kB↓, *PGE2↓, *iNOS↓, *ROS↓, *COX2/PTGS2↓, *toxicity↑,
7103- GEN,    A Comprehensive Review of Genistein's Effects in Preclinical Models of Cervical Cancer
- Review, Cerv, NA
TumCP↓, Apoptosis↑, RadioS↑, ChemoSen↑, *antiOx↑, *Inflam↓, *Bacteria↓, *AntiViral↑, *AntiDiabetic↑, *neuroP↑, AntiCan↑, TumCG↓, TumCI↓, TumCCA↑, cl‑PARP↑, selectivity↑, CycB/CCNB1↓, CDK1↓, p‑cDC2↓, p‑ERK↓, p‑p38↑, p‑JNK↑, MMP9↓, TIMP1↑, BioAv↓, BioAv↑, Half-Life↑,
7102- GEN,    Genistein: An Integrative Overview of Its Mode of Action, Pharmacological Properties, and Health Benefits
- Review, Var, NA
*antiOx↑, *Inflam↓, *Bacteria↓, *AntiViral↑, *Dose↝, *AntiDiabetic↑, angioG↑, Apoptosis↑, tumCV↓, MyD88↑, Beclin-1/ATG6↑, LC3II↑, TLR4↑, TumAuto↑, mTOR↓, p62↓, TumCCA↑, TumCP↓, Akt↑, P53↑, DNMT3B↓, MEK↓, hTERT/TERT↓, VEGF↓, NF-kB↓, IAP1↓, MDR1↓, p‑Akt↓, Synergy↑, ChemoSen↑,
6562- Ger,    Potential Effects of Geraniol on Cancer and Inflammation-Related Diseases: A Review of the Recent Research Findings
- Review, Var, NA - Review, AD, NA
*Inflam↓, *AntiCan↑, *AntiBio↑, *antiOx↑, *neuroP↑, ROS↓, Apoptosis↑, TumCCA↑, P53↝, STAT3↓, Casp↝, *Catalase↑, *GSTs↑, *GPx↑, *AChE↓, *GSH↑, *SOD↑, *TBARS↓, *NO↓, *XO↓, *memory↑, *IL1β↓, *iNOS↓, *NF-kB↓, *COX2/PTGS2↓, *NRF2↑, *HO-1↑, *survivin↓, TumCP↓, TumCMig↓, TumCG↑, selectivity↑, TumMeta↓, angioG↓, Hif1a↓, Beclin-1/ATG6↓, *antiAll↑,
6567- Ger,    Geraniin inhibits proliferation and induces apoptosis through inhibition of phosphatidylinositol 3-kinase/Akt pathway in human colorectal cancer in vitro and in vivo
- vitro+vivo, CRC, SW480 - in-vitro, CRC, HT29
AntiTum↑, *Inflam↓, *antiOx↓, TumCP↓, BAX↑, Casp3↑, Casp9↑, Bcl-2↓, TumCMig↓, TumCI↓, MMP2↓, MMP9↓, p‑PI3K↓, p‑Akt↓, Dose↝, TumCG↓,
6570- Ger,    Apoptosis-Mediated Anticancer Activity of Geraniol Inhibits NF-κB, MAPK, and JAK-STAT-3 Signaling Pathways in Human Thyroid Cancer Cells
- in-vitro, Thyroid, TPC-1
*Inflam↓, AntiCan↑, *neuroP↑, tumCV↓, TumCP↓, ROS↑, Apoptosis?, MMP↓, Bcl-2↓, cycD1/CCND1↓, cMyc↓, COX2/PTGS2↓, TNF-α↓, NF-kB↓, IL6↓, survivin↓, BAX↑, Casp3↑, JAK2↓, STAT3↓, ERK↓,
6571- Ger,    Unlocking the therapeutic potential of Geraniol: an alternative perspective for metabolic disease management
- Review, Obesity, NA
*lipidLev↓, *antiOx↓, Inflam↓, *ROS↓, *BioAv↑, *AntiDiabetic↑, *Obesity↓,
7269- GGB,    Ginkgolide B inactivates the NLRP3 inflammasome by promoting autophagic degradation to improve learning and memory impairment in Alzheimer's disease
- in-vivo, AD, NA
*Inflam↓, *cognitive↑, *NLRP3↓, *neuroP↑,
7217- GGB,    Role of Ginkgolides in the Inflammatory Immune Response of Neurological Diseases: A Review of Current Literatures
- Review, AD, NA
*eff↑, *AntiAg↑, *Apoptosis↓, *antiOx↑, *Inflam↓, *MAPK↓, *NF-kB↓, *PAF↓, *TLR1↓, *MyD88↓, *BDNF↑, *ROS↓, *PARP↓, *Cyt‑c↓,
7140- GI,    Benefits of Ginger and Its Constituent 6-Shogaol in Inhibiting Inflammatory Processes
- Review, Var, NA
*Dose↝, *Inflam↓, *COX2/PTGS2↓, *iNOS↓, *NF-kB↓, *MAPK?, *HO-1↑, *PGE2↓, *TNF-α↓, *IL6↓, *IL1β↓, *IFN-γ↓, *MCP1/CCL2↓, *MIP2↓, *RANTES↓, *MPO↓, *NO↓, *Stroke↓, *BrainVol↑, *MDA↓, *ROS↓, *GSH↑, *NRF2↑, *antiOx↑, NLRP3↓, HDAC1↓,
7141- GI,    Synthesis of New Shogaol Analogues as NRF2 Activators and Evaluation of Their Anti-Inflammatory Activity, Modes of Action and Metabolic Stability
- Study, Nor, BV2
*eff↑, *CompStab↓, *NRF2↑, *Inflam↓, *eff↑, *antiOx↑, *neuroP↑, *COX2/PTGS2↓, *NF-kB↓, *eff↓, *BioAv↝, *CompStab↑,
7142- GI,    Phase II study of the Effects of Ginger Root Extract on Eicosanoids in Colon Mucosa in People at Normal Risk for Colorectal Cancer
- Trial, Nor, NA
COX2/PTGS2↓, *PGE2↓, *5-HETE↓, *12-HETE↓, *Eic↓, *AntiCan↑, *antiOx↑, *Inflam↓, 5LO↓, eff↝,
7135- GI,    Examination of the Pharmacokinetics of Active Ingredients of Ginger in Humans
- Trial, Nor, NA
*Dose↝, *Half-Life↝, *antiOx↑, *Inflam↓, *AntiTum↑, *Half-Life↓,
6771- GI,    A glimpse on influences of ginger and its derivatives as a feed additive in finfish farming: A mini-review
- Review, Nor, NA
*AntiBio↓, *Imm↑, *Inflam↓, *antiOx↑, *SOD↓, *Catalase↓, *GSH↓,
2464- GI,    The Effect of Ginger (Zingiber officinale) on Platelet Aggregation: A Systematic Literature Review
- Review, Nor, NA
*Inflam↓, *antiOx↑, *LDL↓, *AntiAg↑, *AntiAg∅,
1005- GI,    Ginger Constituent 6-Shogaol Inhibits Inflammation- and Angiogenesis-Related Cell Functions in Primary Human Endothelial Cells
- vitro+vivo, Nor, HUVECs
*NF-kB↓, *p65↓, *TLR4∅, *angioG↓, *TumCP↓, *VEGF↓, *Inflam↓, *ICAM-1↓, *VCAM-1↓, *E-sel↓, *p‑JNK↓, *HO-1↑,
4247- GI,    6-Shogaol from Dried Ginger Protects against Intestinal Ischemia/Reperfusion by Inhibiting Cell Apoptosis via the BDNF/TrkB/PI3K/AKT Pathway
- vitro+vivo, AD, NA
*BDNF↑, *TrkB↑, *PI3K↑, *Akt↑, *Apoptosis↓, *Inflam↓, *antiOx↑,
4246- GI,    Ginger oil-loaded transdermal adhesive patch treats post-traumatic stress disorder
- in-vivo, AD, NA
*BDNF↑, *Inflam↓,
7251- Gink,    Ginkgetin: A Promising Multitarget Agent for Diverse Diseases
- Review, Var, NA
*Inflam↓, *antiOx↓, AntiCan↑, *neuroP↑, *cardioP↑, *Bacteria↓, *ROS↓, *lipid-P↓, *NRF2↓, *Keap1↓, *NF-kB↓, *MAPK↓, MMP2↓, M2 MC↓, JAK2↓, STAT3↓, TumCP↓, Casp↑, ChemoSen↑, *BMD↑, *Aβ↓, *Stroke↓, *BioAv↓,
7253- Gink,    Ginkgetin Alleviates Inflammation and Senescence by Targeting STING
- Study, Nor, NA
*cGAS–STING↓, *Inflam↓, *antiOx↑, *AntiAge↑, *DNAdam↓, *cellSen↓,
7260- Gink,    Ginkgetin: A natural biflavone with versatile pharmacological activities
- Review, Var, NA - Review, Stroke, NA - Review, AD, NA
*AntiCan↑, *Inflam↓, *AntiBio↑, *neuroP↑, *TumCCA↑, Apoptosis↑, TumAuto↑, iNOS↓, COX2/PTGS2↓, PGE2↓, NF-kB↓, PLA2↓, *neuroP↑, *Stroke↓, *AntiFungal↓, *Bacteria↓, Bcl-xL↓, Bcl-2↓, Casp9↑, Casp3↑, cl‑PARP↑, IL6↓, STAT3↓, JAK1↓, survivin↓, COX2/PTGS2↓, IAP1↓, MMP2↓, MMP9↓, PTEN↑, SHP1↑, Synergy↑, TumVol↓, TumW↓, *toxicity↓, *ROS↓,

Showing Research Papers: 551 to 600 of 1306
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1306

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 3,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 6,   antiOx↑, 37,   antiOx⇅, 2,   ARE↓, 1,   Catalase↓, 6,   Catalase↑, 6,   Fenton↑, 1,   frataxin↑, 1,   GCLC↑, 1,   GPx↑, 3,   GPx4↓, 5,   GSH↓, 28,   GSH↑, 7,   GSR↑, 1,   GSTs↑, 4,   GSTs↝, 1,   H2O2↓, 1,   H2O2↑, 4,   HO-1↓, 4,   HO-1↑, 18,   HO-2↓, 1,   Iron↑, 4,   Iron↝, 1,   lipid-P?, 1,   lipid-P↓, 5,   lipid-P↑, 12,   MDA↓, 5,   MDA↑, 10,   MPO↓, 5,   NADH↓, 2,   NOX↓, 1,   NOX4↑, 1,   NQO1↓, 1,   NQO1↑, 4,   NRF2↓, 16,   NRF2↑, 22,   Prx↓, 2,   Prx4↑, 1,   PrxII↓, 1,   PYCR1↓, 1,   ROS?, 1,   ROS↓, 36,   ROS↑, 218,   ROS⇅, 7,   ROS↝, 2,   i-ROS↓, 1,   i-ROS↑, 3,   mt-ROS↑, 5,   SOD?, 1,   SOD↓, 7,   SOD↑, 7,   SOD1↑, 1,   SOD2↓, 4,   SOD2↑, 1,   ac‑SOD2↓, 1,   Thiols↓, 2,   Trx↓, 2,   TrxR↓, 2,   TrxR1↓, 2,   xCT/SLC7A11↓, 3,  

Metal & Cofactor Biology(tgid=2) ⓘ

FTH1↓, 1,   IronCh↑, 4,   IronCh∅, 1,   Tf↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↑, 1,   CDC2↓, 2,   CDC25↓, 7,   compI↓, 2,   compII↓, 1,   compIII↓, 1,   compIV↓, 1,   EGF↓, 1,   ETC↓, 2,   HSP60/HSPD1↓, 1,   MFN2↑, 1,   mitResp↓, 1,   mitResp↑, 1,   MKK7↓, 1,   mtDam?, 1,   mtDam↓, 1,   mtDam↑, 23,   OCR↓, 2,   OXPHOS↓, 5,   OXPHOS↝, 1,   PDH↑, 1,   PGC-1α↑, 1,   PINK1↑, 1,   SDH↓, 1,   SIRT3↓, 2,   SIRT3↑, 3,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,   5-HETE↓, 1,   5LO↓, 6,   ACC↑, 1,   ACC1↓, 1,   Acetyl-CoA↓, 1,   ACLY↓, 2,   ACSL4↑, 1,   ALAT↓, 10,   AMPK↓, 1,   AMPK↑, 19,   AMPK↝, 1,   p‑AMT/GCST/T-protein↑, 1,   ATGL/PNPLA2↓, 1,   ATP↓, 20,   ATP↑, 1,   mt-ATP↓, 1,   BHB↑, 1,   Buty↑, 1,   CAIX/CA9↓, 3,   CRM↑, 2,   DHODH↓, 1,   ECAR↓, 1,   ECAR↝, 1,   ENO1↓, 1,   FAO↑, 1,   FASN↓, 8,   FFA/NEFA↓, 1,   G6PD↓, 1,   GLS↓, 1,   glucose↓, 2,   GlucoseCon↓, 9,   glut↓, 1,   GlutMet↓, 2,   Glycolysis↓, 32,   Glycolysis↝, 1,   GSK‐3β↓, 11,   GSK‐3β↑, 6,   GSK‐3β↝, 1,   p‑GSK‐3β↓, 5,   HK2↓, 14,   HMG-CoA↓, 1,   HMGCS2↑, 1,   HSL/LIPE↓, 1,   p‑HSL/LIPE↑, 1,   lactateProd↓, 11,   lactateProd↑, 1,   LDHA↓, 6,   LDL↓, 1,   lipidLev↓, 1,   lipoGen↓, 1,   MCT4↓, 2,   NAD↓, 1,   NAD↑, 2,   NADPH↓, 3,   NADPH↑, 2,   PCK1↓, 1,   PDK1 / PDPK1?, 2,   PDK1 / PDPK1↓, 6,   PDK3↑, 1,   PFK↓, 2,   PKM2↓, 13,   PLA2↓, 1,   Pyruv↓, 1,   SCD1↓, 2,   SCFAs↑, 1,   SIRT1↓, 8,   SIRT1↑, 5,   SREBP1/SREBF1↓, 1,   SREBP2↓, 2,   TCA↓, 2,   Warburg↓, 10,  

Cell Death(tgid=5) ⓘ

AIF↑, 10,   APAF1↑, 9,   Apoptosis?, 4,   Apoptosis↓, 10,   Apoptosis↑, 233,   mt-Apoptosis↑, 1,   ASC↑, 1,   BAD↓, 1,   BAD↑, 7,   Bak↓, 1,   Bak↑, 8,   BAX↓, 4,   BAX↑, 96,   Bax:Bcl2↑, 19,   Bcl-2↓, 116,   Bcl-2↑, 3,   Bcl-xL↓, 24,   Bcl-xL↑, 1,   BID↑, 2,   p‑BID↓, 1,   cl‑BID↑, 1,   BIM↓, 1,   BIM↑, 3,   BNIP3↑, 1,   Casp↓, 1,   Casp↑, 39,   Casp↝, 1,   Casp1↓, 2,   Casp1↑, 2,   cl‑Casp1↓, 1,   Casp10↑, 1,   Casp12↑, 3,   Casp3↓, 7,   Casp3↑, 131,   cl‑Casp3↑, 19,   cl‑Casp3⇅, 1,   proCasp3↓, 1,   Casp6↓, 1,   Casp6↑, 1,   Casp7↑, 18,   cl‑Casp7↑, 5,   Casp8↓, 2,   Casp8↑, 37,   cl‑Casp8↑, 2,   proCasp8↑, 1,   Casp9↓, 2,   Casp9↑, 88,   cl‑Casp9↑, 9,   CellShr↑, 1,   cFLIP↓, 4,   Cyt‑c↓, 3,   Cyt‑c↑, 82,   Diablo↑, 5,   DR5↓, 1,   DR5↑, 15,   DR5↝, 1,   Endon↑, 1,   FADD↑, 3,   Fap1↓, 1,   Fas?, 1,   Fas↓, 2,   Fas↑, 14,   FasL↓, 1,   FasL↑, 4,   Ferroptosis↑, 8,   GranB/GZMB↓, 1,   GranB/GZMB↝, 1,   GSDMD↑, 1,   IAP1↓, 9,   IAP2/BIRC3↓, 4,   IAP2/BIRC3↑, 1,   cl‑IAP2/BIRC3↑, 1,   iNOS↓, 23,   iNOS↑, 1,   Mcl-1↓, 12,   Mcl-1↑, 1,   p‑Mcl-1↓, 1,   cl‑Mcl-1↑, 1,   MDM2↓, 8,   MDM2↑, 2,   p‑MDM2↓, 1,   MOMP↓, 1,   MOMP↑, 5,   Necroptosis↑, 2,   necrosis↑, 3,   NOXA↑, 3,   p38↓, 4,   p38↑, 17,   p‑p38↓, 4,   p‑p38↑, 4,   Paraptosis↑, 1,   Perforin↝, 1,   pS2/TFF1↓, 1,   PUMA↑, 4,   Pyro↑, 3,   survivin↓, 41,   TNFR 1↑, 1,   TRAIL↑, 3,   TRAIL⇅, 1,   TRAILR↑, 2,   TumCD↓, 2,   TumCD↑, 14,   XIAP↓, 26,   XIAP↑, 1,   YAP/TEAD↓, 3,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 135,   Akt↑, 8,   p‑Akt↓, 31,   AKT1↓, 1,   Akt2↓, 1,   CaMKII ?, 1,   CIP2A↓, 1,   CK2↓, 6,   cMET↓, 1,   p‑cMET↑, 1,   CREB↓, 1,   cSrc↓, 2,   DDIT4↑, 1,   EF-1α↓, 1,   EGFR↓, 33,   EGFR↑, 1,   p‑EGFR↓, 1,   ERK↓, 47,   ERK↑, 5,   p‑ERK↓, 17,   p‑ERK↑, 1,   FGFR1↓, 1,   FOXD3↑, 1,   HCAR2↑, 4,   HER2/EBBR2↓, 11,   HGF/c-Met↓, 2,   Hippo↑, 1,   IGF-1R↓, 2,   IGF-1R↑, 1,   IGF-2R↑, 1,   IGFR↓, 1,   IKKα↓, 5,   IκB↓, 2,   JAK↓, 5,   JAK1↓, 3,   JAK1↑, 2,   JAK2↓, 18,   p‑JAK2↓, 1,   JAK3↓, 1,   JNK↓, 9,   JNK↑, 18,   p‑JNK↓, 3,   p‑JNK↑, 7,   LIMK1↓, 1,   MAPK↓, 36,   MAPK↑, 14,   MAPK↝, 1,   p‑MAPK↓, 1,   MARK4↓, 1,   MEK↓, 4,   MKK4↓, 1,   MKP1↝, 1,   mTOR↓, 75,   mTOR↝, 2,   p‑mTOR↓, 9,   mTORC2↓, 2,   OR13G1?, 1,   p70S6↓, 1,   P70S6K↓, 3,   P90RSK↓, 1,   PDE3B↓, 1,   p‑PDGFR-BB↓, 1,   PI3K↓, 114,   PI3K↑, 2,   p‑PI3K↓, 5,   PIK3CA↓, 1,   PKA↓, 2,   p‑PKA↓, 1,   PKCδ↓, 10,   PRKCQ/PKCθ↓, 1,   PTEN↓, 5,   PTEN↑, 28,   Raf↓, 4,   c-Raf↓, 1,   RAS↓, 10,   RAS↑, 1,   Rictor↓, 1,   RIP1↓, 1,   p‑S6K↓, 1,   SHP1↓, 1,   SHP1↑, 2,   Sp1/3/4↓, 12,   STAT↓, 7,   STAT3↓, 78,   STAT3↑, 4,   p‑STAT3↓, 8,   STAT4↓, 1,   STAT6↓, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF2↓, 1,   ATF4↑, 9,   ATF4↝, 1,   CBP↓, 2,   cJun↓, 5,   cJun↑, 1,   p‑cJun↓, 1,   p‑cJun↑, 1,   cMyc↓, 35,   cMyc↑, 1,   DNMT1↓, 7,   DNMT3A↓, 2,   DNMT3B↓, 3,   DNMTs↓, 7,   EZH2↓, 4,   FOXM1↓, 3,   FOXO1↓, 2,   FOXO1↑, 3,   FOXO3↓, 1,   FOXO3↑, 4,   FOXO3↝, 1,   FOXO4↓, 1,   FOXO4↑, 1,   H3↑, 1,   p‑H3↓, 1,   ac‑H3↓, 1,   ac‑H3↑, 1,   H4↑, 2,   ac‑H4↓, 1,   ac‑H4↑, 1,   HATs↓, 5,   HATs↑, 3,   HDAC↓, 22,   HDAC1↓, 7,   HDAC2↓, 5,   HDAC3↓, 5,   HDAC4↓, 1,   HDAC6↓, 2,   HDAC8↓, 3,   HES1↓, 2,   Matr↓, 1,   miR-106b↓, 2,   miR-124-3p↓, 1,   miR-143↑, 1,   miR-148a↑, 1,   miR-155↓, 1,   miR-19b↓, 2,   miR-200b↑, 2,   miR-200c↑, 1,   miR-203↑, 1,   miR-21↓, 5,   miR-218↑, 1,   miR-25-5p↓, 1,   miR-27a-3p↓, 2,   miR-34a↓, 2,   miR-34a↑, 6,   miR-590-3p↑, 1,   Myc↓, 5,   n-MYC↓, 1,   OCT4↓, 8,   other?, 1,   other↓, 5,   other↑, 10,   other⇅, 1,   other↝, 16,   PCAF↓, 2,   PhotoS↑, 3,   sonoS↑, 1,   SOX2↓, 6,   SOX4↓, 2,   SOX4↑, 1,   SOX9?, 1,   SUMO↓, 1,   TCF-4↓, 1,   tumCV?, 2,   tumCV↓, 59,   UTF1↑, 1,   ZBTB10↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 2,   CHOP/DDIT3↓, 2,   CHOP/DDIT3↑, 20,   cl‑CHOP/DDIT3↑, 1,   CUL1↝, 1,   CUL5↝, 1,   eIF2α↑, 6,   p‑eIF2α↓, 1,   p‑eIF2α↑, 1,   ER Stress↓, 1,   ER Stress↑, 37,   GRP78/BiP?, 1,   GRP78/BiP↓, 2,   GRP78/BiP↑, 7,   GRP78/BiP↝, 1,   GRP94↑, 1,   HSP27↓, 5,   HSP70/HSPA5↓, 3,   HSP70/HSPA5↑, 5,   HSP72↓, 1,   HSP90↓, 8,   HSPs↓, 1,   HSPs↑, 1,   HTRA↓, 1,   IRE1↑, 2,   p‑IRE1↓, 1,   NQO2↑, 1,   PERK↑, 8,   p‑PERK↑, 1,   Proteasome↓, 1,   UPR↑, 7,   XBP-1↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 7,   ATG7↑, 1,   Beclin-1/ATG6↓, 3,   Beclin-1/ATG6↑, 13,   CTSK↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 2,   LC3B↑, 1,   LC3B-II↑, 2,   LC3I↑, 1,   LC3II↓, 2,   LC3II↑, 14,   LC3s↑, 1,   MitoP↑, 1,   p62↓, 8,   p62↑, 3,   PARK2↑, 1,   SESN2↑, 2,   TumAuto↓, 1,   TumAuto↑, 47,   TumAuto↝, 1,  

DNA Damage & Repair(tgid=10) ⓘ

8-oxo-dG↓, 1,   ATM↑, 4,   BRCA1↓, 2,   BRCA1↑, 1,   p‑BRCA1↑, 1,   BRCA2↓, 1,   DFF45↑, 1,   DNAdam↓, 6,   DNAdam↑, 55,   DNArepair↓, 3,   hTERT/TERT↓, 8,   MGMT↓, 1,   NHEJ↓, 1,   p16↑, 1,   P53↓, 3,   P53↑, 78,   P53↝, 2,   p‑P53↓, 1,   p‑P53↑, 2,   p53 Wildtype↑, 1,   p73↑, 1,   PARP↓, 3,   PARP↑, 14,   cl‑PARP↓, 2,   cl‑PARP↑, 51,   PARP1↑, 3,   cl‑PARP1↑, 2,   PCNA↓, 32,   POLD1↓, 1,   SIRT6↓, 1,   SIRT6↑, 1,   Telomerase↓, 11,   TOP1↓, 7,   TOP2↓, 5,   TOP2↑, 2,   TP53↓, 2,   TP53↑, 1,   γH2AX↑, 3,  

Cell Cycle & Senescence(tgid=11) ⓘ

CC(CDKs/cyclins)↓, 1,   CDK1↓, 14,   CDK1↑, 3,   CDK2↓, 31,   CDK2↑, 2,   CDK4↓, 36,   CDK4↑, 1,   p‑CDK4↓, 1,   CDK6↓, 11,   CDK6↑, 1,   CDK7↓, 1,   CDK8↓, 2,   CHK1↓, 1,   CHK1↑, 1,   Chk2↑, 2,   Cyc↓, 2,   cycA1/CCNA1↓, 7,   CycB/CCNB1↓, 19,   CycB/CCNB1↑, 3,   cycD1/CCND1↓, 75,   cycD1/CCND1↑, 2,   p‑cycD1/CCND1↓, 1,   CycD3↓, 1,   cycE/CCNE↓, 19,   E2Fs↓, 4,   GADD45A↓, 1,   Ki-67↓, 29,   Ki-67↑, 1,   mitA↑, 2,   P21?, 1,   P21↓, 7,   P21↑, 46,   p‑P21↑, 1,   p27/CDKN1B↓, 3,   p27/CDKN1B↑, 19,   pRB↓, 3,   p‑pRB↓, 3,   RB1↑, 2,   p‑RB1↓, 5,   Securin↓, 1,   TumCCA↓, 3,   TumCCA↑, 186,   WEE1↑, 2,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

4E-BP1↓, 1,   p‑4E-BP1↓, 1,   ALDH↓, 3,   ALDH1A1↓, 3,   BMP7/OP1↓, 1,   BMPs↑, 1,   CD133↓, 6,   CD24↓, 1,   CD34↓, 1,   cFos↓, 4,   CSCs?, 1,   CSCs↓, 32,   Diff↓, 2,   Diff↑, 6,   FGF↓, 1,   Gli↓, 2,   Gli1↓, 3,   HH↓, 4,   IGF-1?, 1,   IGF-1↓, 9,   IGF-2↓, 1,   IGFBP3↑, 2,   JAG1↓, 1,   Jun↓, 1,   Ki-67↓, 29,   Ki-67↑, 1,   Let-7↑, 2,   mTORC1↓, 6,   p‑mTORC1↓, 1,   Nanog↓, 5,   Nestin↓, 3,   NOTCH↓, 14,   NOTCH↑, 1,   NOTCH1↓, 12,   NOTCH1↑, 3,   NOTCH3↓, 2,   p300↓, 3,   PTCH1↓, 1,   SCF↓, 1,   Shh↓, 4,   Smo↓, 2,   STAT1↓, 2,   TumCG↓, 83,   TumCG↑, 4,   TumCP↓, 163,   TumCP↑, 3,   Wnt↓, 37,   Wnt↑, 2,   Wnt/(β-catenin)↓, 3,  

Migration(tgid=13) ⓘ

AntiAg?, 1,   AntiAg↓, 1,   AntiAg↑, 3,   AP-1↓, 9,   AP-1↑, 1,   ASAP2↓, 1,   AXL↓, 1,   BACH1↓, 1,   CA↓, 2,   Ca+2↓, 3,   Ca+2↑, 29,   Ca+2↝, 4,   i-Ca+2?, 1,   i-Ca+2↑, 1,   cal2↑, 1,   Cal9↑, 1,   CCN2/CTGF↓, 3,   Cdc42↓, 1,   Cofilin↓, 1,   p‑Cofilin↑, 1,   COL1↓, 2,   COL3A1↓, 1,   E-cadherin↓, 6,   E-cadherin↑, 32,   EMT↓, 65,   EMT↑, 2,   EMT↝, 1,   EpCAM↓, 2,   F-actin↓, 2,   FAK↓, 17,   FAK↑, 1,   p‑FAK↓, 5,   fascin↓, 1,   Fibronectin↓, 1,   GIT1↓, 1,   GLI2↓, 1,   ITGB1↓, 3,   ITGB3↓, 1,   ITGB4↓, 1,   KRAS↓, 1,   LAMs↓, 2,   LEF1↓, 2,   LIMK2↓, 1,   LRP1↑, 1,   MALAT1↓, 2,   MET↓, 1,   MET↑, 1,   p‑MET↓, 1,   MMP1↓, 6,   MMP13↓, 3,   MMP2↓, 74,   MMP2↑, 1,   MMP3↓, 4,   MMP7↓, 7,   MMP9↓, 93,   MMP9↑, 4,   MMPs↓, 36,   MUC4↓, 2,   N-cadherin↓, 19,   pax↓, 1,   PDGF↓, 6,   PGF↓, 1,   Rac1↓, 2,   RECK↑, 1,   Rho↓, 5,   ROCK1↓, 3,   Slug↓, 8,   Smad1↓, 1,   SMAD2↓, 1,   SMAD3↓, 2,   Snail↓, 13,   TET1↑, 3,   TGF-β↓, 18,   TGF-β↑, 2,   TGF-β1↓, 1,   TIMP1↓, 2,   TIMP1↑, 8,   TIMP2↓, 1,   TIMP2↑, 7,   TIMP3↑, 1,   pol-TregCell↓, 1,   TRIB3↑, 3,   TSP-1↑, 2,   TumCA↓, 3,   TumCI↓, 98,   TumCMig↓, 90,   TumCMig↑, 1,   TumMeta↓, 86,   TumMeta↑, 7,   TumPF↓, 1,   Twist↓, 14,   TXNIP↑, 1,   uPA↓, 19,   uPAR↓, 1,   Vim?, 1,   Vim↓, 16,   Zeb1↓, 9,   Zeb1↑, 1,   ZEB2↓, 1,   α-SMA↓, 3,   α-SMA↑, 1,   α-tubulin↓, 1,   β-catenin/ZEB1↓, 50,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 125,   angioG↑, 2,   CCN1/CYR61↓, 1,   CD31/PECAM-1↓, 5,   Endoglin↑, 1,   eNOS↑, 1,   HIF-1↓, 7,   Hif1a↓, 44,   HIF2a↓, 1,   Hypoxia↓, 1,   LOX1↓, 3,   NO↓, 7,   NO↑, 3,   PGI2↓, 1,   PHDs↓, 1,   VCAM-1↓, 2,   VEGF↓, 100,   VEGF↑, 1,   VEGFR1↓, 1,   VEGFR2/KDR/Flk1↓, 16,  

Barriers & Transport(tgid=15) ⓘ

AQPs↓, 1,   BBB↑, 7,   BBB∅, 1,   CellMemb↑, 1,   CLDN2↓, 1,   CX43/GJA1↓, 1,   EPR↑, 3,   GLUT1↓, 11,   GLUT4↓, 1,   IBI↑, 1,   MMP↓, 111,   MMP↑, 2,   MPT↑, 6,   NHE1↓, 2,   OATPs↓, 1,   TJ↓, 1,   TRPM7↓, 3,   TRPV1↓, 1,   TRPV1↑, 4,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CB2 / CNR2↑, 3,   CCR7↓, 1,   CD25+↓, 1,   CD25+↑, 1,   CD4+↓, 2,   CD4+↑, 2,   CD44↓, 8,   CD47↓, 1,   CD59↑, 1,   CD8+↑, 4,   p‑cDC2↓, 1,   COX1↓, 7,   COX1↑, 1,   COX2/PTGS2↓, 113,   COX2/PTGS2↑, 2,   COX2/PTGS2↝, 1,   CXCc↓, 1,   CXCL12↓, 2,   CXCL16↓, 1,   CXCR4↓, 14,   DR4↑, 4,   Eos↑, 1,   FOXP3↑, 2,   FoxP3+↓, 1,   HCAR2↑, 4,   HLA-I/II↑, 1,   HMGB1↓, 5,   ICAM-1↓, 10,   IFN-γ↓, 8,   IFN-γ↑, 3,   IL1↓, 4,   IL1↑, 1,   IL10↓, 9,   IL10↑, 2,   IL12↑, 2,   IL17↓, 3,   IL17↑, 1,   IL18↓, 1,   IL18↑, 1,   IL1α↓, 1,   IL1β↓, 38,   IL1β↑, 3,   IL2↓, 5,   IL2↑, 3,   IL22↓, 1,   IL23↓, 1,   IL4↓, 3,   IL4↑, 1,   IL5↓, 1,   IL6↓, 61,   IL6↑, 2,   IL8↓, 11,   IL8↑, 1,   Imm↑, 29,   Imm↝, 6,   INF-γ↓, 1,   INF-γ↝, 1,   Inflam↓, 214,   Inflam↑, 3,   Inflam↝, 2,   LPS↓, 1,   LRIG1↑, 1,   M2 MC↓, 1,   MCP1/CCL2↓, 9,   MCT1↓, 2,   MDSCs↓, 1,   MIP-1β↑, 1,   MIP‑1α/CCL3↓, 1,   MIP2↓, 2,   MyD88↓, 1,   MyD88↑, 1,   Neut↑, 2,   NF-kB?, 1,   NF-kB↓, 170,   NF-kB↑, 6,   p‑NF-kB↓, 1,   p‑NF-kB↑, 2,   NK cell↑, 7,   NLRP3↓, 8,   NLRP3↑, 3,   NOD1↓, 1,   p65↓, 4,   p‑p65↓, 3,   PD-1↓, 3,   PD-L1↓, 9,   PGE2↓, 31,   PGE2↑, 1,   PSA↓, 12,   RAGE↓, 2,   RANTES↓, 1,   SOCS-3↓, 1,   T-Cell↑, 2,   TCF↓, 1,   Th1 response↑, 1,   TLR4↓, 10,   TLR4↑, 1,   TNF-α↓, 56,   TNF-α↑, 5,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 1,   Treg lymp↓, 1,   TRIF↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

GFAP↓, 1,   GGT/CD224↓, 1,   pH↓, 1,   pH↝, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   AChE↓, 2,   ADAM10?, 1,   ADAM10↓, 1,   BChE↓, 1,  

Protein Aggregation(tgid=19) ⓘ

BACE/β-secretase↓, 1,   PSEN2/PS-2↓, 1,   p‑tau↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ADRB2↓, 1,   AR↓, 10,   AR-V7?, 1,   CYP19?, 1,   ER(estro)↓, 1,   EstroRS/ERS↑, 1,   PPARα↓, 1,   PPARα↑, 1,   PPARγ↓, 4,   PPARγ↑, 8,   PPARγ↝, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 2,   BioAv↓, 55,   BioAv↑, 59,   BioAv⇅, 1,   BioAv↝, 15,   BioEnh↑, 2,   CBR1↓, 1,   ChemoSen↓, 1,   ChemoSen↑, 181,   ChemoSen⇅, 1,   ChemoSen↝, 1,   CompStab?, 1,   CompStab↑, 3,   CompStab↝, 3,   CYP1A1↓, 5,   CYP1A1↑, 2,   CYP1A2↓, 1,   CYP3A2↓, 1,   CYP3A4↓, 1,   DDS↑, 2,   Dose?, 5,   Dose↓, 3,   Dose↑, 10,   Dose⇅, 1,   Dose↝, 64,   Dose∅, 9,   DrugR↓, 1,   eff↓, 15,   eff↑, 87,   eff⇅, 1,   eff↝, 18,   eff∅, 4,   GSTM1↑, 1,   Half-Life↓, 15,   Half-Life↑, 2,   Half-Life↝, 16,   MDR1↓, 5,   MRP1/ABCC1↓, 3,   MRP1/ABCC1↝, 1,   NAT↓, 1,   P-gp/ABCB1↓, 16,   P-gp/ABCB1↑, 1,   P-gp/ABCB1⇅, 1,   P450↓, 2,   P450↝, 1,   RadioS↑, 53,   selectivity?, 1,   selectivity↓, 1,   selectivity↑, 90,   selectivity∅, 1,   Synergy↓, 1,   Synergy↑, 117,   Synergy↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AFP?, 1,   AFP↓, 3,   ALAT↓, 10,   ALB↑, 1,   ALP↓, 2,   AR↓, 10,   ascitic↓, 1,   AST?, 1,   AST↓, 7,   BloodF⇅, 1,   BP↓, 1,   BRCA1↓, 2,   BRCA1↑, 1,   p‑BRCA1↑, 1,   BUN↓, 1,   CA19-9↓, 1,   CEA↓, 2,   creat↓, 2,   CRP↓, 9,   DBIL↓, 1,   E6↓, 1,   E7↓, 1,   EGFR↓, 33,   EGFR↑, 1,   p‑EGFR↓, 1,   EstroRS/ERS↑, 1,   EZH2↓, 4,   FOXM1↓, 3,   HER2/EBBR2↓, 11,   hTERT/TERT↓, 8,   IBIL↓, 1,   IL6↓, 61,   IL6↑, 2,   KRAS↓, 1,   LDH↓, 7,   LDH↑, 2,   LDH↝, 1,   Maspin↑, 1,   Myc↓, 5,   NLR↓, 1,   NOS2↓, 1,   NOS2↑, 1,   PC↑, 1,   PD-L1↓, 9,   Polyps↓, 1,   PSA↓, 12,   RAGE↓, 2,   RBC↑, 1,   TBIL↓, 1,   TG/TAG↓, 1,   TP53↓, 2,   TP53↑, 1,   TRIB3↑, 3,   Tumccf↓, 2,   WBC↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 2,   AntiArt↑, 1,   AntiCan?, 1,   AntiCan↓, 5,   AntiCan↑, 121,   AntiCan⇅, 1,   AntiCan∅, 1,   antiD↑, 1,   AntiDiabetic↑, 3,   antiNeop↑, 5,   AntiTum↓, 1,   AntiTum↑, 53,   AntiTum∅, 1,   Appetite↑, 1,   cachexia↓, 1,   cardioP↑, 19,   CardioT↑, 2,   chemoP↑, 65,   chemoPv↑, 29,   ChemoSideEff↓, 4,   cognitive?, 1,   cognitive↑, 6,   DCR↑, 1,   fatigue↓, 2,   fatigue∅, 1,   hepatoP↓, 1,   hepatoP↑, 19,   hepatoP∅, 1,   memory↑, 4,   Mood↑, 1,   Mucositis↓, 1,   neuroP↑, 21,   NP/CIPN↓, 3,   Obesity↓, 2,   OS↓, 1,   OS↑, 19,   OS↝, 1,   OS∅, 2,   Pain↓, 6,   PFS↑, 1,   PFS∅, 1,   QoL↑, 8,   QoL∅, 1,   radioP↑, 23,   Remission↑, 1,   RenoP↑, 15,   Risk↓, 41,   Risk↑, 2,   Sleep↑, 2,   toxicity↓, 20,   toxicity↑, 5,   toxicity↝, 13,   toxicity∅, 3,   TumNum↓, 1,   TumVol↓, 16,   TumW↓, 7,   Weight↓, 1,   Weight↑, 3,   Wound Healing↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↓, 1,   AntiViral↑, 2,   Bacteria↓, 5,   GutMicro↑, 18,   Sepsis↓, 4,  

Ingredients & Constituents(tgid=25) ⓘ

Api↑, 1,   Ingr?, 1,   Ingr↝, 9,  
Total Targets: 1058

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

NA↓, 1,   NA↑, 1,   NA↝, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↓, 4,   antiOx?, 2,   antiOx↓, 37,   antiOx↑, 535,   ARE↑, 7,   ARE↝, 1,   Bil↑, 2,   Catalase↓, 4,   Catalase↑, 152,   Copper↓, 1,   DPPH↓, 2,   DUOX1↓, 1,   Fenton↓, 5,   GCLC↑, 4,   GCLC↝, 1,   GCLM↑, 3,   GCLM↝, 1,   GPx↓, 2,   GPx↑, 112,   GPx1↑, 4,   GPx3↑, 1,   GPx4↓, 1,   GPx4↑, 6,   GSH↓, 4,   GSH↑, 162,   GSR↓, 2,   GSR↑, 24,   GSS↑, 1,   GSSG↓, 2,   GSTs↓, 4,   GSTs↑, 27,   H2O2↓, 8,   H2O2∅, 1,   HDL↓, 1,   HDL↑, 13,   HDL∅, 1,   HNE↓, 3,   HO-1?, 1,   HO-1↓, 4,   HO-1↑, 139,   HO-1⇅, 1,   HO-1↝, 1,   HO-2↓, 1,   hyperG↓, 3,   hyperG↝, 1,   Iron↓, 4,   Iron↑, 1,   Iron↝, 1,   Iron∅, 1,   Keap1↓, 8,   Keap1↑, 1,   Keap1↝, 2,   lipid-P?, 1,   lipid-P↓, 143,   lipid-P↑, 3,   mt-lipid-P↓, 1,   MDA↓, 139,   MDA↑, 4,   MPO↓, 28,   MPO↑, 1,   NADH↓, 1,   NFE2L2↓, 1,   NOX↓, 3,   NOX1↓, 1,   NOX2↓, 2,   NOX4↓, 9,   NQO1↑, 35,   NQO1↝, 2,   Nrf1↑, 2,   NRF2?, 1,   NRF2↓, 7,   NRF2↑, 236,   NRF2↝, 1,   NRF2∅, 1,   Prx↓, 1,   Prx↑, 2,   RNS↓, 8,   ROS?, 5,   ROS↓, 567,   ROS↑, 11,   ROS⇅, 4,   ROS↝, 1,   ROS∅, 1,   mt-ROS?, 1,   mt-ROS↓, 2,   SAM-e↑, 1,   selenoP↑, 10,   SOD↓, 6,   SOD↑, 210,   mt-SOD↑, 1,   SOD1↑, 9,   SOD2↓, 1,   SOD2↑, 9,   TAC↑, 24,   TBARS↓, 9,   Thiols↑, 2,   TOS↓, 2,   Trx↓, 1,   Trx↑, 6,   Trx1↑, 2,   TrxR↑, 1,   TrxR1↑, 1,   UCPs↑, 2,   uricA↓, 5,   VitC↑, 9,   VitE↓, 1,   VitE↑, 4,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1,   Ferritin↑, 1,   FPN↑, 1,   FTH1↑, 1,   IronCh↓, 1,   IronCh↑, 22,   IronCh↝, 1,   Mets↝, 1,   NCOA4↝, 1,   TfR1/CD71↓, 1,   TfR1/CD71↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compI↑, 2,   compII↑, 2,   compIII↑, 2,   compIV↑, 3,   DRP1/DNM1L↓, 1,   EGF↓, 1,   EGF↑, 1,   ETC↑, 3,   HSP60/HSPD1↓, 1,   Insulin↓, 4,   Insulin↑, 3,   MFN2↑, 2,   mitResp↑, 3,   mtDam↓, 10,   mtDam↑, 1,   OCR↓, 1,   OCR↑, 4,   OXPHOS↑, 1,   PDH↑, 1,   PGC-1α↓, 3,   PGC-1α↑, 10,   PGC-1α↝, 2,   PINK1↓, 1,   PINK1↑, 2,   SIRT3↑, 8,   TFAM↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12-HETE↓, 1,   12LOX↓, 2,   12LOX↑, 1,   5-HETE↓, 1,   5LO↓, 19,   5LO↝, 1,   ACC↓, 1,   ACC↑, 2,   Acetyl-CoA↓, 1,   Acetyl-CoA↑, 3,   ACSL4↓, 2,   adiP↓, 1,   adiP↑, 4,   ALAT?, 1,   ALAT↓, 55,   ALAT∅, 1,   AMPK↓, 2,   AMPK↑, 47,   p‑AMPK↑, 3,   ATP↓, 1,   ATP↑, 28,   ATP↝, 1,   BHB↑, 1,   Buty↑, 1,   cAMP↑, 6,   CPT1A↑, 1,   CRM↑, 3,   cytoP450↓, 1,   ECAR↓, 1,   Eic↓, 1,   FABP4↓, 1,   FAO↓, 1,   FAO↑, 3,   FASN↓, 3,   FFA/NEFA↓, 1,   G6PD↑, 1,   GAPDH↑, 1,   glucose↓, 18,   glucose↑, 2,   glucose↝, 4,   GlucoseCon↓, 1,   GlucoseCon↑, 11,   Glycolysis↓, 3,   Glycolysis↑, 1,   GSK‐3β↓, 25,   GSK‐3β↑, 2,   p‑GSK‐3β↓, 1,   p‑GSK‐3β↑, 4,   H2S↑, 2,   HK2↓, 2,   HMG-CoA↓, 3,   KeyT↝, 1,   lactateProd↓, 1,   LDHA↓, 2,   LDL↓, 43,   lipidLev↓, 7,   lipoGen↓, 1,   LTB4↓, 1,   LTC4↓, 1,   NAD↓, 1,   NAD↑, 3,   NAD↝, 1,   NADH:NAD↑, 1,   NADPH↓, 15,   NADPH↑, 10,   PDKs↓, 1,   PFK↓, 1,   PFK1↓, 1,   PFKP↓, 1,   PGC1A↑, 1,   PGM1?, 1,   PKM2↓, 8,   PLA2↓, 2,   PONs↓, 1,   PONs↑, 1,   SCFAs↑, 1,   SIRT1↓, 1,   SIRT1↑, 48,   SIRT1↝, 1,   SIRT2↑, 1,   SREBF2⇅, 1,   SREBP1/SREBF1↓, 1,   SREBP1/SREBF1↑, 1,   Warburg↓, 1,  

Cell Death(tgid=5) ⓘ

AIF↓, 2,   APAF1↓, 1,   Apoptosis↓, 75,   Apoptosis↑, 2,   ASK1↓, 1,   BAD↓, 1,   BAX↓, 27,   BAX↑, 1,   Bax:Bcl2↓, 5,   Bcl-2↓, 5,   Bcl-2↑, 22,   Bcl-2↝, 1,   Bcl-xL↑, 1,   BNIP3↓, 1,   Casp↓, 4,   Casp1↓, 3,   Casp12↓, 2,   Casp3↓, 49,   Casp3↑, 3,   Casp3∅, 1,   cl‑Casp3↓, 6,   proCasp3↓, 1,   Casp6↓, 1,   Casp8↓, 2,   cl‑Casp8↓, 1,   cl‑Casp8↑, 1,   Casp9↓, 19,   Casp9↑, 2,   Cyt‑c↓, 8,   Cyt‑c↑, 1,   Cyt‑c∅, 2,   Fas↓, 2,   Ferroptosis↓, 14,   GranB/GZMB↓, 1,   GRP58↓, 1,   GSDMD?, 1,   GSDMD↓, 1,   iNOS↓, 88,   iNOS↑, 3,   necrosis↓, 3,   p38↓, 9,   p38↑, 1,   p‑p38↓, 7,   Pyro↓, 1,   survivin↓, 1,   TUNEL↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 13,   Akt↑, 36,   Akt↝, 1,   p‑Akt↓, 6,   p‑Akt↑, 4,   AKT1↓, 1,   Akt2↓, 1,   AMPKα↑, 2,   CREB↓, 1,   CREB↑, 9,   p‑CREB↑, 3,   DYRK1A↓, 2,   EGFR↓, 1,   ERK↓, 14,   ERK↑, 14,   p‑ERK↓, 4,   p‑ERK↑, 3,   HCAR2↑, 1,   HER2/EBBR2↓, 1,   HGF/c-Met↑, 2,   IGF-1R↓, 1,   IKKα↓, 3,   IKKα↑, 1,   p‑IKKα↓, 1,   IκB?, 1,   JAK↓, 3,   JAK2↓, 3,   JAK2↑, 3,   JNK↓, 20,   JNK↑, 1,   p‑JNK↓, 7,   MAPK?, 1,   MAPK↓, 46,   MAPK↑, 5,   MAPK↝, 2,   p‑MAPK?, 1,   p‑MAPK↓, 2,   MEK↓, 1,   Mst1↓, 1,   mTOR↓, 14,   mTOR↑, 8,   mTOR↝, 1,   p‑mTOR↓, 5,   P70S6K↓, 1,   PDGFR-BB↓, 2,   PDGFR-BB↑, 1,   PDGFRB↓, 1,   PI3K↓, 12,   PI3K↑, 25,   PI3K↝, 1,   PKA↑, 3,   PKCδ↓, 4,   PKCδ↑, 6,   PP2A↑, 4,   PTEN↓, 5,   PTEN↑, 1,   PTP1B↓, 1,   RAS↓, 1,   RIP1↓, 1,   STAT↓, 4,   STAT3?, 1,   STAT3↓, 11,   STAT3↑, 5,   p‑STAT3↓, 1,   p‑STAT3↑, 1,   STAT4↓, 1,   STAT5↓, 1,   STEP↓, 1,   STK11/LKB1↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 14,   ATF2↑, 1,   ATF4↓, 4,   cJun↓, 2,   p‑cJun↓, 1,   cMyc↓, 1,   p‑cMyc↑, 1,   DNMT1↓, 2,   DNMT3A↓, 1,   DNMTs↓, 2,   FOXO↑, 3,   FOXO3↑, 6,   HATs↓, 2,   HDAC?, 1,   HDAC↓, 4,   HDAC↑, 2,   HDAC2↓, 2,   HOTAIR↑, 1,   KLF4↑, 1,   miR-155↓, 1,   miR-34a↓, 1,   OCT4↓, 1,   other?, 3,   other↓, 19,   other↑, 32,   other↝, 51,   other∅, 1,   SOX2↑, 1,   SOX9↑, 2,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↓, 1,   CHOP/DDIT3↓, 13,   CHOP/DDIT3↑, 1,   eIF2α↓, 1,   p‑eIF2α↓, 1,   ER Stress↓, 28,   ER Stress↑, 1,   GRP78/BiP↓, 11,   GRP78/BiP↑, 3,   GRP94↑, 1,   HSF1↑, 1,   HSP27↑, 1,   HSP70/HSPA5↓, 1,   HSP70/HSPA5↑, 12,   HSP70/HSPA5↝, 1,   HSP90↓, 1,   HSP90↑, 2,   HSPs↓, 1,   HSPs↑, 2,   HSPs↝, 1,   IRE1↓, 3,   NQO2↑, 1,   PERK↓, 1,   p‑PERK↓, 1,   UPR↓, 1,   UPR↑, 2,   XBP-1↓, 3,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 1,   ATG7↓, 1,   autophagy↓, 1,   autophagy↑, 1,   Beclin-1/ATG6↓, 3,   Beclin-1/ATG6↑, 8,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3B↓, 1,   LC3B↑, 3,   LC3II↓, 2,   LC3II↑, 4,   MitoP↓, 1,   MitoP↑, 3,   p62↓, 3,   p62↑, 4,   PARK2↑, 4,   TFEB↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

8-oxo-dG↓, 1,   ATR↑, 1,   DNAdam↓, 30,   p16↓, 2,   P53↓, 6,   PARP↓, 2,   PARP1↓, 2,   cl‑PARP1↓, 1,   PCNA↓, 4,   SIRT6↑, 1,   Telomerase↓, 1,   TOP1↓, 1,   TP53↑, 1,   γH2AX↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1,   CDK4↓, 1,   CDK5↓, 2,   cellSen↓, 1,   cellSen↝, 1,   cycD1/CCND1↓, 2,   cycE/CCNE↓, 1,   E2Fs↑, 1,   GADD34↓, 1,   Ki-67↓, 1,   Ki-67↑, 2,   P21↓, 3,   RB1↓, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMPs↑, 1,   CEBPA↓, 1,   cFos↑, 1,   CHIP↑, 1,   Choline↑, 2,   Diff↑, 4,   Diff↝, 2,   EP2↓, 1,   FGF↑, 3,   GH↑, 1,   HH↓, 1,   IGF-1↓, 1,   IGF-1↑, 4,   IGFBP1↑, 1,   Jun↓, 1,   Ki-67↓, 1,   Ki-67↑, 2,   MSCs↑, 1,   mTORC1↓, 1,   Nestin↑, 1,   neuroG↑, 12,   NOTCH1↑, 1,   STAT1↓, 1,   TumCG↑, 1,   TumCP↓, 5,   tyrosinase↓, 1,   Wnt/(β-catenin)↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↓, 5,   AntiAg↑, 43,   AntiAg∅, 1,   AP-1↓, 11,   AP-1↑, 1,   ARG1/2↑, 1,   Ca+2?, 2,   Ca+2↓, 18,   Ca+2↑, 7,   Ca+2↝, 4,   cal2↓, 1,   Cartilage↑, 9,   COL1↓, 2,   COL1↑, 2,   COL2A1↑, 2,   COL3A1↓, 1,   E-cadherin↑, 2,   EMT↓, 2,   EMT↑, 1,   F-actin↑, 1,   FAK↑, 1,   Fibronectin↓, 1,   Fibronectin↑, 1,   Fibrosis↓, 1,   ITGA5↓, 1,   ITGB1↓, 1,   LRP1↑, 3,   MLC2/MYL9↝, 1,   MMP-10↓, 2,   MMP-10↝, 1,   MMP1↓, 1,   MMP13↓, 6,   MMP2↓, 7,   MMP2↑, 2,   MMP3↓, 3,   MMP3↑, 1,   MMP9↓, 21,   MMP9↑, 2,   MMPs↓, 3,   MMPs↑, 3,   MUC1↑, 4,   N-cadherin↑, 1,   Na+↑, 1,   NFAT↓, 1,   PDGF↓, 1,   PDGF↑, 1,   p‑Rac1↓, 1,   Rho↓, 3,   ROCK1↓, 4,   serineP↓, 1,   SLIT2↑, 1,   SMAD3↓, 1,   Snail↑, 1,   p‑T-cadherin↓, 1,   TGF-β↓, 10,   TGF-β↑, 10,   TGF-β1↓, 4,   TGF-β1↑, 3,   TIMP1↓, 5,   TIMP1↑, 3,   TIMP2↑, 2,   TumCI↓, 2,   TumCMig↓, 1,   TumMeta↓, 1,   Twist↑, 1,   TXNIP↓, 6,   Tyro3↓, 1,   uPA↑, 1,   Vim↓, 2,   Vim↑, 1,   α-SMA↓, 6,   α-SMA↑, 1,   α-SMA↝, 1,   α-tubulin↓, 1,   β-catenin/ZEB1↑, 2,   β-catenin/ZEB1↝, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 9,   angioG↑, 8,   angioG↝, 1,   CD31/PECAM-1↓, 1,   CD31/PECAM-1↑, 1,   E-sel↓, 5,   ECM/TCF↑, 1,   eNOS↓, 1,   eNOS↑, 4,   p‑eNOS↑, 1,   HIF-1↓, 1,   Hif1a↓, 8,   Hif1a↑, 3,   Hif1a↝, 1,   Hif1a∅, 1,   HIF2a↑, 1,   LOX1↓, 1,   NO?, 1,   NO↓, 67,   NO↑, 7,   P-sel↓, 1,   TXA2↓, 3,   VCAM-1↓, 19,   VEGF↓, 13,   VEGF↑, 11,   VEGFR2/KDR/Flk1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB?, 2,   BBB↓, 8,   BBB↑, 80,   BBB↝, 6,   BBB∅, 3,   CLDN1↓, 2,   CLDN1↑, 3,   CLDN3↑, 1,   CLDN4↑, 1,   EPR↑, 2,   GastroP↑, 14,   GLUT1↑, 2,   GLUT2↑, 1,   GLUT3↑, 2,   GLUT4↑, 6,   H+/K+-ATPase↓, 1,   IBI↑, 12,   ketosis↑, 1,   memfluid↑, 2,   MMP↓, 2,   MMP↑, 30,   MMP∅, 2,   MUC19↓, 1,   MUC2↓, 1,   MUC2↑, 1,   MUC5AC↓, 2,   Na+↑, 1,   OATPs↓, 1,   OCLN↓, 2,   OCLN↑, 6,   OCLN↝, 1,   TJ↓, 1,   TJ↑, 6,   TRPA1↑, 2,   TRPC1↓, 1,   TRPM7↓, 1,   TRPV1↑, 5,   TRPV3↑, 2,   VGCC↓, 1,   VGSC↓, 1,   ZO-1↓, 2,   ZO-1↑, 9,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

AIF1/Iba-1↓, 1,   BALF-Infl↓, 1,   BALF-Lym↓, 1,   CB2 / CNR2↑, 5,   CCL11↓, 1,   CD19↑, 1,   CD25+↑, 1,   CD4+↑, 5,   CD40↓, 1,   CD8+↑, 1,   cGAS–STING↓, 2,   COX1↓, 14,   COX1↑, 1,   COX2/PTGS2?, 1,   COX2/PTGS2↓, 144,   COX2/PTGS2↑, 2,   CXCc↓, 1,   CXCL1↓, 1,   CXCL15↓, 1,   CXCR2↓, 1,   CXCR3↓, 1,   CXCR4↓, 1,   Eos↓, 5,   FOXP3↑, 1,   GM-CSF↓, 1,   HCAR2↑, 1,   HMGB1↓, 9,   ICAM-1↓, 17,   IFN-γ↓, 21,   IFN-γ↑, 4,   IFN-γ∅, 1,   IgE↓, 4,   IgG1↓, 1,   IL1?, 1,   IL1↓, 11,   IL1↑, 1,   IL10?, 1,   IL10↓, 16,   IL10↑, 32,   IL12↓, 8,   IL13↓, 6,   IL17↓, 16,   IL17↑, 1,   IL18↓, 4,   IL1RL1/ST2↓, 1,   IL1α↓, 1,   IL1β↓, 164,   IL1β↑, 1,   IL2↓, 15,   IL2↑, 1,   IL22↓, 1,   IL23↓, 3,   IL33↓, 3,   IL4↓, 20,   IL4↑, 7,   IL5↓, 8,   IL5↑, 1,   IL6?, 3,   IL6↓, 197,   IL6↑, 4,   IL8?, 1,   IL8↓, 35,   IL8↑, 1,   ILC2↓, 1,   Imm↓, 1,   Imm↑, 48,   Imm↝, 4,   INF-γ↓, 3,   Inflam?, 6,   Inflam↓, 1076,   Inflam↑, 16,   Inflam∅, 2,   IP-10/CXCL-10↓, 2,   IRF3↓, 4,   LPS↓, 2,   LTA/TNF-β↓, 1,   LTA/TNF-β↑, 1,   M2 MC↑, 1,   pol-M2 MC↑, 1,   MCP1/CCL2↓, 21,   MCP1/CCL2↑, 2,   MCP1/CCL2↝, 1,   MIP‑1α/CCL3↓, 2,   MIP2↓, 3,   MyD88↓, 8,   NeuroI↓, 4,   Neut↓, 1,   Neut↑, 2,   NF-kB↓, 249,   NF-kB↑, 2,   p‑NF-kB↓, 4,   NK cell↑, 6,   NLRP3↓, 67,   NLRP3↑, 4,   p65↓, 6,   PAF↓, 2,   PAF↑, 1,   PGE1↓, 1,   PGE2↓, 52,   PGE2↑, 2,   PSA↓, 1,   PSA∅, 1,   RAGE↓, 5,   RANTES↓, 4,   Th1 response↓, 1,   Th17↓, 1,   Th2↓, 2,   TLR1↓, 3,   TLR2↓, 8,   TLR3↓, 1,   TLR4↓, 36,   TLR4↑, 1,   TLR4∅, 1,   TNF-α?, 1,   TNF-α↓, 269,   TNF-α↑, 4,   TRAF1↓, 1,   Treg lymp↑, 1,   Treg lymp↝, 1,   TRIF↓, 3,   VitD↑, 2,  

Cellular Microenvironment(tgid=17) ⓘ

GFAP↓, 3,   GGT/CD224↓, 1,   TREM2↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5-AR↓, 2,   5HT↓, 1,   5HT↑, 16,   Ach↑, 25,   AChE↓, 98,   AChE↑, 1,   AChE∅, 2,   ADAM10↑, 6,   ADAM10↝, 1,   BChE↓, 24,   BChE∅, 1,   BDNF↓, 3,   BDNF↑, 71,   BDNF∅, 2,   proBDNF↑, 1,   BrainVol↑, 2,   ChAT↑, 13,   ChE↓, 1,   GABA↓, 3,   GABA↑, 9,   GABA↝, 1,   MAOA↓, 13,   MAOB↓, 4,   monoA↑, 1,   NGF↑, 9,   PSD95↑, 6,   SNAP25↑, 2,   SYP↑, 1,   TPH1↓, 1,   TrkB↑, 8,  

Protein Aggregation(tgid=19) ⓘ

AEP↓, 1,   AGEs↓, 12,   APOE4↓, 1,   APP↓, 15,   APP∅, 1,   cl‑APP↑, 1,   Aβ↓, 164,   Aβ↑, 2,   Aβ∅, 2,   Aβ42↓, 10,   BACE/β-secretase↓, 37,   BACE/β-secretase↑, 1,   IDE↑, 1,   NEP↑, 1,   PSEN1/PS1↑, 1,   tau↓, 37,   p‑tau↓, 49,   XO↓, 2,   XO↝, 1,   β-Amyloid↓, 2,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 1,   ACE2↓, 1,   AhR↑, 2,   AR↓, 1,   BNP↓, 1,   cortisol↓, 1,   cortisol↑, 1,   CYP19↓, 1,   DHT↑, 1,   ER(estro)↓, 1,   ER(estro)↑, 2,   ERβ/ESR2↑, 1,   Estro↓, 1,   GLP-1R↑, 1,   GR↑, 1,   NR1H4↑, 1,   PPARα↑, 10,   PPARα↝, 1,   PPARγ↓, 5,   PPARγ↑, 24,   RAAS↓, 1,   SHBG↓, 1,   testos↑, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 84,   BioAv↑, 127,   BioAv⇅, 3,   BioAv↝, 74,   BioEnh↑, 12,   ChemoSen↑, 3,   CompStab↓, 2,   CompStab↑, 7,   CompStab↝, 3,   CYP2C19↓, 1,   CYP2C9↓, 1,   CYP2D6↓, 1,   CYP2E1↓, 1,   CYP3A4↓, 1,   DDS↑, 1,   Dose?, 10,   Dose↓, 3,   Dose↑, 9,   Dose↝, 148,   eff?, 1,   eff↓, 9,   eff↑, 88,   eff↝, 11,   GSTA1↑, 7,   Half-Life?, 1,   Half-Life↓, 18,   Half-Life↑, 9,   Half-Life↝, 31,   P-gp/ABCB1↓, 3,   P450↓, 3,   P450↑, 1,   RadioS↑, 1,   selectivity↑, 5,   Synergy↑, 50,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT?, 1,   ALAT↓, 55,   ALAT∅, 1,   ALB↑, 2,   ALB↝, 1,   ALP↓, 10,   anemia↓, 1,   AR↓, 1,   AST↓, 56,   AST∅, 1,   BG↓, 4,   Bil↑, 2,   BloodF↑, 13,   BMD↑, 8,   BP↓, 30,   BP↝, 1,   BP∅, 1,   BUN?, 1,   BUN↓, 6,   Calcium↑, 1,   Calcium↝, 2,   CEA↓, 1,   CK/CK-MB↓, 1,   colonLen↑, 2,   creat↓, 16,   CRP↓, 22,   EGFR↓, 1,   Ferritin↓, 1,   Ferritin↑, 1,   HbA1c↓, 1,   Hcy/homoC↓, 3,   Hcy/homoC↝, 1,   HemoG↑, 2,   HER2/EBBR2↓, 1,   HOMA↓, 1,   hs-CRP↓, 5,   IL6?, 3,   IL6↓, 197,   IL6↑, 4,   IRes↓, 1,   IRes↑, 1,   IRes↝, 1,   KeyT↝, 1,   LDH↓, 19,   LDH↑, 1,   Mag↑, 1,   NLR↓, 1,   NOS2↓, 5,   PSA↓, 1,   PSA∅, 1,   PV↓, 3,   RAGE↓, 5,   RBC↑, 1,   SpO2↑, 1,   TC↓, 5,   TG/TAG↓, 6,   TMAO↓, 1,   TMAO↑, 1,   TP53↑, 1,   UFR?, 1,   UFR↑, 2,   UR↓, 1,   Urea↓, 5,   VitD↑, 2,  

Functional Outcomes(tgid=23) ⓘ

Airway↓, 2,   AirwayM↓, 4,   Analgesic↑, 6,   AntiAge↑, 35,   antiAll?, 1,   antiAll↑, 47,   AntiArt↑, 18,   AntiCan?, 1,   AntiCan↓, 2,   AntiCan↑, 82,   antiCG↑, 2,   antiD↑, 1,   AntiDiabetic↓, 2,   AntiDiabetic↑, 93,   antiM↑, 1,   AntiMyl↑, 1,   antiNeop↑, 1,   antiPs↑, 3,   antiPy↑, 1,   AntiTum↓, 2,   AntiTum↑, 26,   ANXi↓, 1,   BOLD↑, 1,   Bone Healing↑, 1,   cachexia↓, 1,   cardioP?, 1,   cardioP↓, 3,   cardioP↑, 180,   cardioP⇅, 1,   cardioP∅, 1,   chemoP↑, 28,   chemoPv↑, 21,   ChemoSideEff↓, 1,   cognitive↓, 4,   cognitive↑, 221,   cognitive↝, 1,   cognitive∅, 1,   cough?, 1,   diuretic↑, 6,   fatigue↓, 3,   Hear↑, 1,   hepatoP↓, 5,   hepatoP↑, 164,   IPSS↝, 1,   Learn?, 1,   Learn↑, 16,   memory?, 1,   memory↑, 186,   memory∅, 1,   Mood↑, 13,   motorD↓, 1,   motorD↑, 24,   Mucositis↓, 2,   neuroP?, 3,   neuroP↓, 3,   neuroP↑, 405,   neuroP↝, 1,   NP/CIPN↓, 3,   Obesity↓, 39,   OS↑, 15,   Pain↓, 27,   PDE4↓, 1,   QoL↓, 1,   QoL↑, 9,   radioP↑, 16,   RenoP↑, 50,   Risk↓, 19,   Risk↑, 1,   Sleep↑, 8,   SoreThr?, 1,   Strength↓, 1,   Strength↑, 8,   Stress↓, 3,   Stroke↓, 31,   Tinn↓, 1,   toxicity?, 1,   toxicity↓, 93,   toxicity↑, 12,   toxicity⇅, 1,   toxicity↝, 22,   toxicity∅, 11,   Weight↓, 6,   Weight↑, 2,   Weight∅, 1,   Wound Healing↓, 1,   Wound Healing↑, 21,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↓, 1,   AntiBio↑, 54,   AntiFungal↓, 2,   AntiFungal↑, 24,   AntiP↓, 1,   AntiP↑, 7,   AntiViral↑, 38,   Bacteria↓, 89,   Bacteria↑, 1,   Diar↓, 6,   Dysb↓, 1,   GutMicro↑, 93,   GutMicro↝, 2,   Inf↓, 3,   Sepsis↓, 20,  

Ingredients & Constituents(tgid=25) ⓘ

Api↑, 1,   CA↑, 1,   Catechins↑, 1,   FA↑, 1,   Fibre↑, 1,   Flav↑, 1,   GA↑, 1,   Ingr?, 2,   Ingr↑, 6,   Ingr↝, 35,   LT↑, 1,   Myr↑, 1,   Phen↑, 1,   Poly↑, 1,   QC↑, 2,  
Total Targets: 1030

Scientific Paper Hit Count for: Inflam, inflammation
43 Hydrogen Gas
41 Curcumin
34 Magnetic Fields
33 Thymoquinone
32 Quercetin
30 Silymarin (Milk Thistle) silibinin
24 Resveratrol
20 Lycopene
18 Alpha-Lipoic-Acid
18 Berberine
18 Selenium NanoParticles
18 Fisetin
18 Rosmarinic acid
16 Ashwagandha(Withaferin A)
16 Ferulic acid
16 Sulforaphane (mainly Broccoli)
15 Capsaicin
15 Carvacrol
15 Honokiol
15 Kaempferol
15 Luteolin
15 Urolithin
14 Propolis -bee glue
14 Emodin
14 Eugenol
14 Licochalcone A
13 Silver-NanoParticles
13 Apigenin (mainly Parsley)
13 Beta-Caryophyllene
12 Radiotherapy/Radiation
12 Baicalein
12 Chlorogenic acid
12 Chrysin
11 Cinnamon
11 Isoliquiritigenin
10 Crocetin
10 Chemotherapy
10 Dandelion Root
10 EGCG (Epigallocatechin Gallate)
10 Matrine
10 Pterostilbene
9 Selenite (Sodium)
9 Isovitexin
9 Boron
9 Ginger/6-Shogaol/Gingerol
9 Magnolol
9 Morin
8 Astaxanthin
8 Boswellia (frankincense)
8 α-Bisabolol / Chamomile oil
8 Rutin
8 Diclofenac
8 Fucoidan
8 Licorice
8 Piperlongumine
8 Vitamin C (Ascorbic Acid)
8 Shikonin
7 Allicin (mainly Garlic)
7 Betulinic acid
7 Vitamin B3,Niacin
7 Cisplatin
7 Butyrate
7 Centella asiatica / Gotu kola → asiaticoside
7 D-limonene
7 Gallic acid
7 Hyperoside
7 Moringa oleifera
7 Mushroom Lion’s Mane, Hericium erinaceus
7 Piperine
6 1,8-Cineole
6 Artemisinin
6 Aspirin
6 Caffeic acid
6 Thymol-Thymus vulgaris
6 Hydroxycinnamic-acid
6 Flaxseed/Linseed
6 Garcinol
6 HydroxyTyrosol
6 isoorientin
6 Vitexin
6 L-Theanine
6 Methylsulfonylmethane
5 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
5 Melatonin
5 Folic Acid, Vit B9
5 Phenethyl isothiocyanate
5 doxorubicin
5 Caffeic Acid Phenethyl Ester (CAPE)
5 Celastrol
5 chitosan
5 Chocolate
5 Coenzyme Q10
5 Ellagic acid
5 Shilajit/Fulvic Acid
5 isoquercitrin
5 Mung Bean Sprouts
5 Lactoferrin/Talactoferrin
5 Magnetic Field Rotating
5 Phycocyanin
5 Ursolic acid
4 Isothiocyanates
4 Bacopa monnieri
4 Cichoric acid / Chicoric acid
4 Carvone
4 Ginkgo biloba-EGb 761
4 Formononetin
4 SDG/lignans
4 Ginkgo biloba
4 Geraniol
4 Ginkgetin
4 Isobavachalcone
4 Isorhamnetin
4 Lemongrass Extract/Citral
4 Methylene blue
4 nicotinamide adenine dinucleotide
4 Nimbolide
4 Patchouli Oil (Pogostemon cablin)
4 Taurine
4 Vitamin B5,Pantothenic Acid
4 Vitamin D3
4 Vitamin K2
3 Anethole/trans-Anethole
3 Baicalin
3 Biochanin A
3 Vitamin B12
3 Benzyl isothiocyanate
3 Bromelain
3 Black Rice, Oryza sativa
3 Lecithin
3 Carnosine
3 Camu camu
3 Chyawanprash
3 methotrexate
3 Spermidine
3 Cucurbitacin
3 Date Fruit Extract
3 Docosahexaenoic Acid
3 eicosapentaenoic acid
3 diet Fermented Foods
3 Exercise
3 Gamma-aminobutyric acid
3 Genistein (soy isoflavone)
3 HydroxyCitric Acid
3 Inositol
3 phytic acid, Inositol hexakisphosphate
3 Linalool
3 5-fluorouracil
3 Mangiferin
3 Marjoram (Origanum majorana)
3 Purple Corn / Purple Maize
3 α-Santalol/Sandalwood oil
3 Sulfasalazine
3 Sesamin
3 Vitamin B1/Thiamine
2 Anthocyanins
2 alpha Linolenic acid
2 Fennel Oil/Foeniculum vulgare
2 Allyl isothiocyanate
2 brusatol
2 borneol
2 buckwheat sprouts
2 Paclitaxel/Taxol
2 Cat’s Claw
2 Celecoxib
2 Chlorophyllin
2 Choline
2 Selenium
2 Vitamin E
2 Cynara scolymus/Globe Artichoke/Artichoke Extract
2 Galantamine
2 Huperzine A/Huperzia serrata
2 diet Short Term Fasting
2 Indole-3-carbinol
2 Dipyridamole
2 Echinacea
2 Eurycomanone
2 flavonoids
2 Germanium Organic/Ge-132 / propagermanium (organogermanium)
2 Ginkgolide B
2 Ginseng
2 Grapeseed extract
2 hydrogen sulfide
2 Orlistat
2 Hibiscus sabdariffa
2 Oleuropein
2 iodine
2 Inulin Prebiotic
2 isoflavones
2 Ivermectin
2 Juglone
2 Potassium
2 probiotics
2 Lutein
2 MBE, Maqui berry
2 Methyl salicylate / Sweet Birch oil
2 Metformin
2 Magnesium
2 Lemon Balm/Melissa officinalis
2 Naringin
2 Oleocanthal
2 Phenylbutyrate
2 Phosphatidylserine
2 Salvia officinalis
2 Shankhpushpi
2 Salvia miltiorrhiza
2 Terpinen-4-ol / Tea Tree Oil
2 Aflavin-3,3′-digallate
2 Turmerones
2 Zyflamend
1 2-DeoxyGlucose
1 5-Hydroxytryptophan
1 Annona atemoya Seed Extract
1 Açaí, Euterpe oleracea
1 Astragalus
1 Acetyl-l-carnitine
1 Aloe anthraquinones
1 beta-glucans
1 xanthohumol
1 Cannabidiol
1 beta-carotene(VitA)
1 Vitamin B6,pyridoxine
1 Bifidobacterium
1 Brucea javanica
1 Beetroot
1 Bruteridin(bergamot juice)
1 Black Seed Oil/Nigella sativa
1 Carnosic acid
1 Castalagin
1 Cannabichromene
1 Cynanbungeigenin C (CBC) and D (CBD)
1 chaetocin
1 Prebiotic
1 Carica papaya leaf extract
1 Calorie Restriction Mimetics
1 Copper and Cu NanoParticles
1 Rivastigmine
1 Chlorella (Chlorella vulgaris)
1 Cynaropicrin
1 Deguelin
1 Dihydrocaffeic Acid
1 diet Ketogenic
1 Diindolylmethane
1 Disulfiram
1 immunotherapy
1 Electrical Pulses
1 Evodiamine
1 Ascorbyl Palmitate
1 Flickering Light Stimulation
1 Iron
1 Galloflavin
1 Gambogic Acid
1 Ginkgolic acids
1 Bifidobacterium animalis subsp. lactis GCL2505
1 γ-linolenic acid (Borage Oil)
1 Gossypol/AT-101
1 Graviola
1 Germacranolide sesquiterpene lactone
1 Siegesbeckia glabrescens
1 Helleborus niger extracts – Christmas Rose
1 Hops (Humulus lupulus)
1 Butein
1 Scopoletin
1 Lactobacillus
1 Zeaxanthin
1 Modified Citrus Pectin
1 irinotecan
1 MCT oil
1 Moringin
1 Mucuna pruriens/Velvet Bean
1 Mushroom Chaga, Inonotus obliquus
1 Nasturtium, Indian Cress
1 Neem
1 Oregano
1 Peppermint
1 Propyl gallate
1 Phenolic Acids
1 Propranolol
1 Psoralidin
1 Parthenolide
1 Pumpkin Seed Oil / Cucurbita pepo
1 Tamsulosin
1 EMF
1 Radio Frequency
1 Aromatherapy
1 Gold NanoParticles
1 Sesame seeds and Oil
1 Silicic Acid
1 Spirulina(Arthrospira/Limnospira)
1 cetuximab
1 Terminalia bellirica
1 Terpenoids
1 Thyme
1 Vitamin A, Retinoic Acid
1 Vitamin B2,Riboflavin
1 Walnut
1 Zinc
1 Zerumbone
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:953  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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