Cancer Database Query Results

Scientific Papers found: Click to Expand⟱
5318- ALC,    Efficacy and Effectiveness of Carnitine Supplementation for Cancer-Related Fatigue: A Systematic Literature Review and Meta-Analysis
- Review, Var, NA
fatigue↝,
5319- ALC,    l-carnitine and cancer cachexia: Clinical and experimental aspects
- Review, Var, NA
fatigue↓, QoL↑, *GSH↑, Dose↝,
4283- ALC,    Rapid-acting antidepressant-like effects of acetyl-l-carnitine mediated by PI3K/AKT/BDNF/VGF signaling pathway in mice
- in-vivo, NA, NA
*BDNF↑, *p‑Akt↑, *PI3K↑,
4512- aLinA,  GLA,    Evening primrose oil: a comprehensive review of its bioactives, extraction, analysis, oil quality, therapeutic merits, and safety
- in-vivo, Nor, NA
*other↝,
3435- aLinA,    Alpha-linolenic acid-mediated epigenetic reprogramming of cervical cancer cell lines
- in-vitro, Cerv, HeLa - in-vitro, Cerv, SiHa - in-vitro, Cerv, C33A
DNMTs↓, HDAC↓, HATs↑, hTERT/TERT↓, CDH1↑, RARβ↑, DNMT1↓, DNMT3A↓, TET2↑, HDAC1↓, HDAC8↓, SIRT1↓, HMTs↑, EZH2↓,
5262- aLinA,    The Role of Alpha-Linolenic Acid and Other Polyunsaturated Fatty Acids in Mental Health: A Narrative Review
- Review, AD, NA
*neuroP↑, *Risk↓, *cognitive↑, *Inflam↓, *antiOx↑, *BDNF↑,
1252- aLinA,    α-Linolenic acid induces apoptosis, inhibits the invasion and metastasis, and arrests cell cycle in human breast cancer cells by inhibiting fatty acid synthase
- in-vitro, BC, NA
FASN↓, Apoptosis↑, TumCI↓, TumMeta↓, TumCCA↑,
1253- aLinA,    The Antitumor Effects of α-Linolenic Acid
- Review, NA, NA
PPARγ↑, COX2↓, E6↓, E7↓, P53↑, p‑ERK↓, p38↓, lipid-P↑, ROS⇅, MPT↑, MMP↓, Cyt‑c↑, Casp↑, iNOS↓, NO↓, Casp3↑, Bcl-2↓, Hif1a↓, FASN↓, CRP↓, IL6↓, IL1β↓, IFN-γ↓, TNF-α↓, Twist↓, VEGF↓, MMP2↓, MMP9↓,
1123- aLinA,    Linoleic acid induces an EMT-like process in mammary epithelial cells MCF10A
- in-vitro, BC, NA - in-vitro, NA, MCF10
TumCP↑, E-cadherin↓, Snail↑, Twist↑, ZEB2↑, FAK↑, NF-kB↑, MMP2↓, MMP9↓, *EMT↑, TumCI↑,
5361- almon,    Abstract CT190: A multicenter, open-label, single-arm, phase II study: The third generation EGFR tyrosine kinase inhibitor almonertinib for pretreated EGFR T790M-positive locally advanced or metastatic non-small cell lung cancer (APOLLO)
- Trial, NSCLC, NA
EGFR↓, OS↑, Dose↝,
5360- almon,  BEV,    Case report: Almonertinib in combination with bevacizumab for leptomeningeal metastases from epidermal growth factor receptor-mutation non-small cell lung cancer: Case series
- Case Report, NSCLC, NA
BBB↑, Dose↝, eff↓, OS↑,
5359- almon,    Aumolertinib as adjuvant therapy in resected EGFR-mutated non-small-cell lung cancer (ARTS): a double-blind, multicentre, randomised, controlled, phase 3 trial
- Trial, NSCLC, NA
eff↑, EGFR↓,
5358- almon,    Experimental Study of Almonertinib Crossing the Blood-Brain Barrier in EGFR-Mutant NSCLC Brain Metastasis and Spinal Cord Metastasis Models
- vitro+vivo, NSCLC, NA
TumMeta↓, BBB↑, EGFR↓,
5357- almon,    AENEAS: A Randomized Phase III Trial of Aumolertinib Versus Gefitinib as First-Line Therapy for Locally Advanced or MetastaticNon-Small-Cell Lung Cancer With EGFR Exon 19 Deletion or L858R Mutations
- Trial, NSCLC, NA
EGFR↓, eff↝, OS↑,
4124- Alum,    The potential influence of silica present in drinking water on Alzheimer's disease and associated disorders
- Review, AD, NA
*cognitive↓,
4130- Alum,    Silica and aluminum in drinking water and cognitive impairment in the elderly
- Study, AD, NA
*cognitive↓,
4132- Alum,    Relation between aluminum concentrations in drinking water and Alzheimer's disease: an 8-year follow-up study
- Study, AD, NA
*Risk↑, *cognitive↓, *BioAv↑,
4135- Alum,    Aluminum Should Now Be Considered a Primary Etiological Factor in Alzheimer's Disease
- Review, AD, NA
*Risk↑, *cognitive↓, *neuroP↓, *other↑, *other↝,
1440- AMQ,    Lysosomotropism depends on glucose: a chloroquine resistance mechanism
- in-vitro, BC, 4T1
eff↑, Apoptosis↓, Necroptosis↑, eff↓, ChemoSen↑, eff↓,
6594- Anamu,    Dibenzyl trisulfide induces caspase-independent death and lysosomal membrane permeabilization of triple-negative breast cancer cells
- in-vitro, BC, HCC1806/CRL-2335 - in-vitro, BC, MDA-MB-231 - in-vitro, BC, MDA-MB-468
TumCP↓, TumCMig↓, Bak↑, GADD45A↑, LTA/TNF-β↑, lysoMP↑, P450↓, cl‑PARP↑, Dose↝,
6602- Anamu,    Dibenzyl Trisulfide Inhibits the Proliferation and Metastasis of Nsclc Via Suppressing Jak/Stat3 Signal Pathway
- vitro+vivo, NSCLC, H1299 - in-vitro, NSCLC, A549
TumCP↓, TumCMig↓, TumCI↓, Apoptosis↑, BAX↑, Bcl-2↓, EMT↓, p‑STAT3↓, TumCG↓,
6601- Anamu,    Petiveria alliacea Reduces Tumor Burden and Metastasis and Regulates the Peripheral Immune Response in a Murine Myeloid Leukemia Model
- in-vitro, AML, NA
AntiTum↑, GlucoseCon↓, ROS↑, TumCP↓, eff↓, Glycolysis↓,
6600- Anamu,  AgNPs,    Characterization, antimicrobial, antioxidant, and anticoagulant activities of silver nanoparticles synthesized from Petiveria alliacea L. leaf extract
- in-vitro, Nor, NA
*Bacteria↓, *AntiFungal↑, *AntiAg↑,
6599- Anamu,    Potential behavioral and pro-oxidant effects of Petiveria alliacea L. extract in adult rats
*Dose↝, *motorD↑, *memory↑, *ROS↑,
6598- Anamu,    Amazonian Plants: A Global Bibliometric Approach to Petiveria alliacea L. Pharmacological and Toxicological Properties
- Review, Var, NA
*AChE↓, *antiOx↓, ATP↓, *toxicity↓,
6597- Anamu,    Dibenzyl trisulfide inhibits proliferation and induces apoptosis of HN30 cells via Akt/ p53 signaling pathway
- in-vitro, HNSCC, HN30 - in-vitro, Tong, SCC25
tumCV↓, Apoptosis↑, MMP↓, cl‑Casp3↑, Bcl-2↓, p‑Akt↓, p‑P53↑, TumCP↓,
6596- Anamu,    Effect of Petiveria alliacea Extracts on Metabolism of K562 Myeloid Leukemia Cells
- in-vitro, AML, K562
TumCP↓, OCR↓, ATP↓, TumCCA↑, ECAR↑, Glycolysis↓, lactateProd↓, mitResp↓,
6595- Anamu,    Dibenzyl trisulfide binds to and competitively inhibits the cytochrome P450 1A1 active site without impacting the expression of aryl hydrocarbon receptor
- in-vivo, Nor, NA
CYP1A1↓, CYP1B1↓, chemoPv↑,
552- Anamu,  NaHCO3,    A critical review of the therapeutic potential of dibenzyl trisulphide isolated from Petiveria alliacea L (guinea hen weed, anamu)
- Review, NA, NA
p‑MAPK↑, Th1 response↓, Th2↑, Albumin↝,
553- Anamu,    The anti-inflammatory and analgesic effects of a crude extract of Petiveria alliacea L. (Phytolaccaceae)
- in-vivo, NA, NA
TumCMig↓,
554- Anamu,    Petiveria alliacea extracts uses multiple mechanisms to inhibit growth of human and mouse tumoral cells
- in-vitro, NA, 769-P
TumCCA↑, HSP70/HSPA5↓, HSP90↓,
931- And,    Effect of Andrographis Paniculata Aqueous Extract on Hyperammonemia Induced Alteration of Oxidative and Nitrosative Stress Factors in the Liver, Spleen and Kidney of Rats
- in-vivo, NA, NA
*SOD↝, *Catalase↝, *ROS↓, *MDA↓, *NO↓,
1093- And,    Andrographolide attenuates epithelial‐mesenchymal transition induced by TGF‐β1 in alveolar epithelial cells
- in-vitro, Lung, A549
TGF-β↓, TumCMig↓, MMP2↓, MMP9↓, ECM/TCF↓, p‑SMAD2↓, p‑SMAD3↓, SMAD4↓, p‑ERK↓, ROS↓, NOX4↓, SOD2↑, SIRT1↑, FOXO3↑,
1078- And,    Andrographolide inhibits breast cancer through suppressing COX-2 expression and angiogenesis via inactivation of p300 signaling and VEGF pathway
- in-vitro, BC, MDA-MB-231 - in-vitro, Nor, HUVECs - in-vivo, BC, MCF7 - in-vitro, BC, T47D - in-vitro, BC, BT549 - in-vitro, BC, MDA-MB-361
TumCP↓, COX2↓, *angioG↓, Cyt‑c↑, CREB2↓, cFos↓, NF-kB↓, HATs↓, cl‑Casp3↑, cl‑Casp9↑, Bax:Bcl2↑, Apoptosis↑, *toxicity↓,
1009- And,  5-FU,    Andrographis-mediated chemosensitization through activation of ferroptosis and suppression of β-catenin/Wnt-signaling pathways in colorectal cancer
- in-vivo, CRC, HCT116 - in-vitro, CRC, SW480
ChemoSen↑, Casp9↑, Ferroptosis↑, Wnt/(β-catenin)↓, FTL↑, TP53↑, ACSL5↑, GCLC↑, GCLM↑, SAT1↑, STEAP3↑, ACSL5↑,
1007- And,    In vitro and in silico evaluation of Andrographis paniculata ethanolic crude extracts on fatty acid synthase expression on breast cancer cells
- in-vitro, BC, MCF7 - in-vitro, BC, EMT6
tumCV↓, i-FASN↓,
1279- And,    Andrographolide Exhibits Anticancer Activity against Breast Cancer Cells (MCF-7 and MDA-MB-231 Cells) through Suppressing Cell Proliferation and Inducing Cell Apoptosis via Inactivation of ER-α Receptor and PI3K/AKT/mTOR Signaling
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF7
Apoptosis↑, Bcl-2↓, BAX↑, ERα/ESR1↓, PI3K↓, mTOR↓,
1156- And,    Exploring the potential of Andrographis paniculata for developing novel HDAC inhibitors: an in silico approach
- Analysis, NA, NA
HDAC↓,
1157- And,    Andrographolide suppresses the migratory ability of human glioblastoma multiforme cells by targeting ERK1/2-mediated matrix metalloproteinase-2 expression
- in-vitro, GBM, GBM8401 - in-vitro, GBM, U251
TumCI↓, TumCMig↓, MMP2↓, ERK↝,
1158- And,  GEM,    Andrographolide causes apoptosis via inactivation of STAT3 and Akt and potentiates antitumor activity of gemcitabine in pancreatic cancer
TumCP↓, TumCCA↑, Apoptosis↑, STAT3↓, Akt↓, P21↑, BAX↑, cycD1/CCND1↓, cycE/CCNE↓, survivin↓, XIAP↓, Bcl-2↓, eff↑,
1159- And,    Andrographolide, an Anti-Inflammatory Multitarget Drug: All Roads Lead to Cellular Metabolism
- Review, NA, NA
NRF2↑, COX2↓, IL6↓, IL8↓, IL1↓, iNOS↓, MPO↓, TNF-α↓, VEGF↓, Hif1a↓, p‑AMPK↑,
1352- And,    Andrographolide downregulates the v-Src and Bcr-Abl oncoproteins and induces Hsp90 cleavage in the ROS-dependent suppression of cancer malignancy
- in-vitro, AML, K562
Apoptosis↑, ROS↑, HSP90↓,
1353- And,    Andrographolide Induces Apoptosis and Cell Cycle Arrest through Inhibition of Aberrant Hedgehog Signaling Pathway in Colon Cancer Cells
- in-vitro, Colon, HCT116
ChemoSen↑, TumCCA↑, CDK1↓, CycB/CCNB1↓, HH↓, Smo↓, Gli1↓,
1354- And,    Andrographolide induces protective autophagy and targeting DJ-1 triggers reactive oxygen species-induced cell death in pancreatic cancer
- in-vitro, PC, NA - in-vivo, PC, NA
Apoptosis↑, DJ-1↓, ROS↑, TumAuto↑, TumCCA↑, TumCP↓, TumW↓, eff↓,
1351- And,  MEL,    Impact of Andrographolide and Melatonin Combinatorial Drug Therapy on Metastatic Colon Cancer Cells and Organoids
- in-vitro, CRC, T84 - in-vitro, CRC, COLO205 - in-vitro, CRC, HT-29 - in-vitro, CRC, DLD1
eff↑, Ki-67↓, Casp3↑, ER Stress↑, ROS↑, BAX↑, XBP-1↑, CHOP/DDIT3↑, eff↑,
1294- And,  5-FU,    Andrographolide reversed 5-FU resistance in human colorectal cancer by elevating BAX expression
- in-vitro, CRC, HCT116
Apoptosis↑, BAX↑,
1350- And,  Cisplatin,    Synergistic antitumor effect of Andrographolide and cisplatin through ROS-mediated ER stress and STAT3 inhibition in colon cancer
- in-vitro, Colon, NA
ChemoSen↑, ER Stress↑, STAT3↓, ROS↑,
1349- And,    Andrographolide promoted ferroptosis to repress the development of non-small cell lung cancer through activation of the mitochondrial dysfunction
- in-vitro, Lung, H460 - in-vitro, Lung, H1650
TumCG↓, TumMeta↓, Ferroptosis↑, ROS↑, MDA↑, Iron↑, GSH↓, GPx4↓, xCT↓, MMP↓, ATP↓,
1347- And,    Suppression of rat neutrophil reactive oxygen species production and adhesion by the diterpenoid lactone andrographolide
- in-vitro, Nor, NA
*ROS↓,
1348- And,    Andrographolide Inhibits ER-Positive Breast Cancer Growth and Enhances Fulvestrant Efficacy via ROS-FOXM1-ER-α Axis
- in-vitro, BC, MCF7 - in-vitro, BC, T47D - in-vivo, NA, NA
ERα/ESR1↓, TumCG↓, ROS↑, FOXM1↓, eff↑,

Showing Research Papers: 601 to 650 of 7354
Prev Page 13 of 148 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 7354

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

CYP1A1↓, 1,   DJ-1↓, 1,   Ferroptosis↑, 2,   GCLC↑, 1,   GCLM↑, 1,   GPx4↓, 1,   GSH↓, 1,   Iron↑, 1,   lipid-P↑, 1,   MDA↑, 1,   MPO↓, 1,   NOX4↓, 1,   NRF2↑, 1,   ROS↓, 1,   ROS↑, 7,   ROS⇅, 1,   SOD2↑, 1,   xCT↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

FTL↑, 1,   STEAP3↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↓, 3,   mitResp↓, 1,   MMP↓, 3,   MPT↑, 1,   OCR↓, 1,   XIAP↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACSL5↑, 2,   p‑AMPK↑, 1,   ECAR↑, 1,   FASN↓, 2,   i-FASN↓, 1,   GlucoseCon↓, 1,   Glycolysis↓, 2,   lactateProd↓, 1,   PPARγ↑, 1,   RARβ↑, 1,   SAT1↑, 1,   SIRT1↓, 1,   SIRT1↑, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,   p‑Akt↓, 1,   Apoptosis↓, 1,   Apoptosis↑, 9,   Bak↑, 1,   BAX↑, 5,   Bax:Bcl2↑, 1,   Bcl-2↓, 5,   Casp↑, 1,   Casp3↑, 2,   cl‑Casp3↑, 2,   Casp9↑, 1,   cl‑Casp9↑, 1,   Cyt‑c↑, 2,   Ferroptosis↑, 2,   hTERT/TERT↓, 1,   iNOS↓, 2,   lysoMP↑, 1,   p‑MAPK↑, 1,   Necroptosis↑, 1,   p38↓, 1,   survivin↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

EZH2↓, 1,   HATs↓, 1,   HATs↑, 1,   tumCV↓, 2,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 1,   ER Stress↑, 2,   HSP70/HSPA5↓, 1,   HSP90↓, 2,   XBP-1↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

TumAuto↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

CYP1B1↓, 1,   DNMT1↓, 1,   DNMT3A↓, 1,   DNMTs↓, 1,   GADD45A↑, 1,   P53↑, 1,   p‑P53↑, 1,   cl‑PARP↑, 1,   TP53↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 1,   cycE/CCNE↓, 1,   P21↑, 1,   TumCCA↑, 6,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

cFos↓, 1,   CREB2↓, 1,   EMT↓, 1,   ERK↝, 1,   p‑ERK↓, 2,   FOXM1↓, 1,   FOXO3↑, 1,   Gli1↓, 1,   HDAC↓, 2,   HDAC1↓, 1,   HDAC8↓, 1,   HH↓, 1,   HMTs↑, 1,   mTOR↓, 1,   PI3K↓, 1,   Smo↓, 1,   STAT3↓, 2,   p‑STAT3↓, 1,   TumCG↓, 3,   Wnt/(β-catenin)↓, 1,  

Migration(tgid=13) ⓘ

CDH1↑, 1,   E-cadherin↓, 1,   FAK↑, 1,   Ki-67↓, 1,   MMP2↓, 4,   MMP9↓, 3,   p‑SMAD2↓, 1,   p‑SMAD3↓, 1,   SMAD4↓, 1,   Snail↑, 1,   TGF-β↓, 1,   TumCI↓, 3,   TumCI↑, 1,   TumCMig↓, 5,   TumCP↓, 8,   TumCP↑, 1,   TumMeta↓, 3,   Twist↓, 1,   Twist↑, 1,   ZEB2↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

ECM/TCF↓, 1,   EGFR↓, 4,   Hif1a↓, 2,   NO↓, 1,   VEGF↓, 2,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2↓, 3,   CRP↓, 1,   IFN-γ↓, 1,   IL1↓, 1,   IL1β↓, 1,   IL6↓, 2,   IL8↓, 1,   LTA/TNF-β↑, 1,   NF-kB↓, 1,   NF-kB↑, 1,   Th1 response↓, 1,   Th2↑, 1,   TNF-α↓, 2,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ERα/ESR1↓, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ChemoSen↑, 4,   Dose↝, 4,   eff↓, 5,   eff↑, 6,   eff↝, 1,   P450↓, 1,   TET2↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

Albumin↝, 1,   CRP↓, 1,   E6↓, 1,   E7↓, 1,   EGFR↓, 4,   ERα/ESR1↓, 2,   EZH2↓, 1,   FOXM1↓, 1,   hTERT/TERT↓, 1,   IL6↓, 2,   Ki-67↓, 1,   TP53↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiTum↑, 1,   chemoPv↑, 1,   fatigue↓, 1,   fatigue↝, 1,   OS↑, 3,   QoL↑, 1,   TumW↓, 1,  
Total Targets: 172

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 1,   Catalase↝, 1,   GSH↑, 1,   MDA↓, 1,   ROS↓, 2,   ROS↑, 1,   SOD↝, 1,  

Cell Death(tgid=5) ⓘ

p‑Akt↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↑, 1,   other↝, 2,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

EMT↑, 1,   PI3K↑, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   NO↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Inflam↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 1,   BDNF↑, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 1,   Dose↝, 1,  

Functional Outcomes(tgid=23) ⓘ

cognitive↓, 4,   cognitive↑, 1,   memory↑, 1,   motorD↑, 1,   neuroP↓, 1,   neuroP↑, 1,   Risk↓, 1,   Risk↑, 2,   toxicity↓, 2,  

Infection & Microbiome(tgid=24) ⓘ

AntiFungal↑, 1,   Bacteria↓, 1,  
Total Targets: 32

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:%  State#:%  Dir#:%
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