Cancer Database Query Results

Scientific Papers found: Click to Expand⟱
5262- aLinA,    The Role of Alpha-Linolenic Acid and Other Polyunsaturated Fatty Acids in Mental Health: A Narrative Review
- Review, AD, NA
*neuroP↑, *Risk↓, *cognitive↑, *Inflam↓, *antiOx↑, *BDNF↑,
1123- aLinA,    Linoleic acid induces an EMT-like process in mammary epithelial cells MCF10A
- in-vitro, BC, NA - in-vitro, NA, MCF10
TumCP↑, E-cadherin↓, Snail↑, Twist↑, ZEB2↑, FAK↑, NF-kB↑, MMP2↓, MMP9↓, *EMT↑, TumCI↑,
5361- almon,    Abstract CT190: A multicenter, open-label, single-arm, phase II study: The third generation EGFR tyrosine kinase inhibitor almonertinib for pretreated EGFR T790M-positive locally advanced or metastatic non-small cell lung cancer (APOLLO)
- Trial, NSCLC, NA
EGFR↓, OS↑, Dose↝,
5360- almon,  BEV,    Case report: Almonertinib in combination with bevacizumab for leptomeningeal metastases from epidermal growth factor receptor-mutation non-small cell lung cancer: Case series
- Case Report, NSCLC, NA
BBB↑, Dose↝, eff↓, OS↑,
5359- almon,    Aumolertinib as adjuvant therapy in resected EGFR-mutated non-small-cell lung cancer (ARTS): a double-blind, multicentre, randomised, controlled, phase 3 trial
- Trial, NSCLC, NA
eff↑, EGFR↓,
5358- almon,    Experimental Study of Almonertinib Crossing the Blood-Brain Barrier in EGFR-Mutant NSCLC Brain Metastasis and Spinal Cord Metastasis Models
- vitro+vivo, NSCLC, NA
TumMeta↓, BBB↑, EGFR↓,
5357- almon,    AENEAS: A Randomized Phase III Trial of Aumolertinib Versus Gefitinib as First-Line Therapy for Locally Advanced or MetastaticNon-Small-Cell Lung Cancer With EGFR Exon 19 Deletion or L858R Mutations
- Trial, NSCLC, NA
EGFR↓, eff↝, OS↑,
4124- Alum,    The potential influence of silica present in drinking water on Alzheimer's disease and associated disorders
- Review, AD, NA
*cognitive↓,
4130- Alum,    Silica and aluminum in drinking water and cognitive impairment in the elderly
- Study, AD, NA
*cognitive↓,
4132- Alum,    Relation between aluminum concentrations in drinking water and Alzheimer's disease: an 8-year follow-up study
- Study, AD, NA
*Risk↑, *cognitive↓, *BioAv↑,
4135- Alum,    Aluminum Should Now Be Considered a Primary Etiological Factor in Alzheimer's Disease
- Review, AD, NA
*Risk↑, *cognitive↓, *neuroP↓, *other↑, *other↝,
1440- AMQ,    Lysosomotropism depends on glucose: a chloroquine resistance mechanism
- in-vitro, BC, 4T1
eff↑, Apoptosis↓, Necroptosis↑, eff↓, ChemoSen↑, eff↓,
6596- Anamu,    Effect of Petiveria alliacea Extracts on Metabolism of K562 Myeloid Leukemia Cells
- in-vitro, AML, K562
TumCP↓, OCR↓, ATP↓, TumCCA↑, ECAR↑, Glycolysis↓, lactateProd↓, mitResp↓,
6597- Anamu,    Dibenzyl trisulfide inhibits proliferation and induces apoptosis of HN30 cells via Akt/ p53 signaling pathway
- in-vitro, HNSCC, HN30 - in-vitro, Tong, SCC25
tumCV↓, Apoptosis↑, MMP↓, cl‑Casp3↑, Bcl-2↓, p‑Akt↓, p‑P53↑, TumCP↓,
6598- Anamu,    Amazonian Plants: A Global Bibliometric Approach to Petiveria alliacea L. Pharmacological and Toxicological Properties
- Review, Var, NA
*AChE↓, *antiOx↓, ATP↓, *toxicity↓,
6599- Anamu,    Potential behavioral and pro-oxidant effects of Petiveria alliacea L. extract in adult rats
*Dose↝, *motorD↑, *memory↑, *ROS↑,
6600- Anamu,  AgNPs,    Characterization, antimicrobial, antioxidant, and anticoagulant activities of silver nanoparticles synthesized from Petiveria alliacea L. leaf extract
- in-vitro, Nor, NA
*Bacteria↓, *AntiFungal↑, *AntiAg↑,
6601- Anamu,    Petiveria alliacea Reduces Tumor Burden and Metastasis and Regulates the Peripheral Immune Response in a Murine Myeloid Leukemia Model
- in-vitro, AML, NA
AntiTum↑, GlucoseCon↓, ROS↑, TumCP↓, eff↓, Glycolysis↓,
6602- Anamu,    Dibenzyl Trisulfide Inhibits the Proliferation and Metastasis of Nsclc Via Suppressing Jak/Stat3 Signal Pathway
- vitro+vivo, NSCLC, H1299 - in-vitro, NSCLC, A549
TumCP↓, TumCMig↓, TumCI↓, Apoptosis↑, BAX↑, Bcl-2↓, EMT↓, p‑STAT3↓, TumCG↓,
6595- Anamu,    Dibenzyl trisulfide binds to and competitively inhibits the cytochrome P450 1A1 active site without impacting the expression of aryl hydrocarbon receptor
- in-vivo, Nor, NA
CYP1A1↓, CYP1B1↓, chemoPv↑,
6594- Anamu,    Dibenzyl trisulfide induces caspase-independent death and lysosomal membrane permeabilization of triple-negative breast cancer cells
- in-vitro, BC, HCC1806/CRL-2335 - in-vitro, BC, MDA-MB-231 - in-vitro, BC, MDA-MB-468
TumCP↓, TumCMig↓, Bak↑, GADD45A↑, LTA/TNF-β↑, lysoMP↑, P450↓, cl‑PARP↑, Dose↝,
552- Anamu,  NaHCO3,    A critical review of the therapeutic potential of dibenzyl trisulphide isolated from Petiveria alliacea L (guinea hen weed, anamu)
- Review, NA, NA
p‑MAPK↑, Th1 response↓, Th2↑, Albumin↝,
553- Anamu,    The anti-inflammatory and analgesic effects of a crude extract of Petiveria alliacea L. (Phytolaccaceae)
- in-vivo, NA, NA
TumCMig↓,
554- Anamu,    Petiveria alliacea extracts uses multiple mechanisms to inhibit growth of human and mouse tumoral cells
- in-vitro, NA, 769-P
TumCCA↑, HSP70/HSPA5↓, HSP90↓,
931- And,    Effect of Andrographis Paniculata Aqueous Extract on Hyperammonemia Induced Alteration of Oxidative and Nitrosative Stress Factors in the Liver, Spleen and Kidney of Rats
- in-vivo, NA, NA
*SOD↝, *Catalase↝, *ROS↓, *MDA↓, *NO↓,
1093- And,    Andrographolide attenuates epithelial‐mesenchymal transition induced by TGF‐β1 in alveolar epithelial cells
- in-vitro, Lung, A549
TGF-β↓, TumCMig↓, MMP2↓, MMP9↓, ECM/TCF↓, p‑SMAD2↓, p‑SMAD3↓, SMAD4↓, p‑ERK↓, ROS↓, NOX4↓, SOD2↑, SIRT1↑, FOXO3↑,
1078- And,    Andrographolide inhibits breast cancer through suppressing COX-2 expression and angiogenesis via inactivation of p300 signaling and VEGF pathway
- in-vitro, BC, MDA-MB-231 - in-vitro, Nor, HUVECs - in-vivo, BC, MCF-7 - in-vitro, BC, T47D - in-vitro, BC, BT549 - in-vitro, BC, MDA-MB-361
TumCP↓, COX2↓, *angioG↓, Cyt‑c↑, CREB2↓, cFos↓, NF-kB↓, HATs↓, cl‑Casp3↑, cl‑Casp9↑, Bax:Bcl2↑, Apoptosis↑, *toxicity↓,
1009- And,  5-FU,    Andrographis-mediated chemosensitization through activation of ferroptosis and suppression of β-catenin/Wnt-signaling pathways in colorectal cancer
- in-vivo, CRC, HCT116 - in-vitro, CRC, SW480
ChemoSen↑, Casp9↑, Ferroptosis↑, Wnt/(β-catenin)↓, FTL↑, TP53↑, ACSL5↑, GCLC↑, GCLM↑, SAT1↑, STEAP3↑, ACSL5↑,
1007- And,    In vitro and in silico evaluation of Andrographis paniculata ethanolic crude extracts on fatty acid synthase expression on breast cancer cells
- in-vitro, BC, MCF-7 - in-vitro, BC, EMT6
tumCV↓, i-FASN↓,
1279- And,    Andrographolide Exhibits Anticancer Activity against Breast Cancer Cells (MCF-7 and MDA-MB-231 Cells) through Suppressing Cell Proliferation and Inducing Cell Apoptosis via Inactivation of ER-α Receptor and PI3K/AKT/mTOR Signaling
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF-7
Apoptosis↑, Bcl-2↓, BAX↑, ERα/ESR1↓, PI3K↓, mTOR↓,
1156- And,    Exploring the potential of Andrographis paniculata for developing novel HDAC inhibitors: an in silico approach
- Analysis, NA, NA
HDAC↓,
1157- And,    Andrographolide suppresses the migratory ability of human glioblastoma multiforme cells by targeting ERK1/2-mediated matrix metalloproteinase-2 expression
- in-vitro, GBM, GBM8401 - in-vitro, GBM, U251
TumCI↓, TumCMig↓, MMP2↓, ERK↝,
1158- And,  GEM,    Andrographolide causes apoptosis via inactivation of STAT3 and Akt and potentiates antitumor activity of gemcitabine in pancreatic cancer
TumCP↓, TumCCA↑, Apoptosis↑, STAT3↓, Akt↓, P21↑, BAX↑, cycD1/CCND1↓, cycE/CCNE↓, survivin↓, XIAP↓, Bcl-2↓, eff↑,
1159- And,    Andrographolide, an Anti-Inflammatory Multitarget Drug: All Roads Lead to Cellular Metabolism
- Review, NA, NA
NRF2↑, COX2↓, IL6↓, IL8↓, IL1↓, iNOS↓, MPO↓, TNF-α↓, VEGF↓, Hif1a↓, p‑AMPK↑,
1352- And,    Andrographolide downregulates the v-Src and Bcr-Abl oncoproteins and induces Hsp90 cleavage in the ROS-dependent suppression of cancer malignancy
- in-vitro, AML, K562
Apoptosis↑, ROS↑, HSP90↓,
1353- And,    Andrographolide Induces Apoptosis and Cell Cycle Arrest through Inhibition of Aberrant Hedgehog Signaling Pathway in Colon Cancer Cells
- in-vitro, Colon, HCT116
ChemoSen↑, TumCCA↑, CDK1↓, CycB/CCNB1↓, HH↓, Smo↓, Gli1↓,
1354- And,    Andrographolide induces protective autophagy and targeting DJ-1 triggers reactive oxygen species-induced cell death in pancreatic cancer
- in-vitro, PC, NA - in-vivo, PC, NA
Apoptosis↑, DJ-1↓, ROS↑, TumAuto↑, TumCCA↑, TumCP↓, TumW↓, eff↓,
1351- And,  MEL,    Impact of Andrographolide and Melatonin Combinatorial Drug Therapy on Metastatic Colon Cancer Cells and Organoids
- in-vitro, CRC, T84 - in-vitro, CRC, COLO205 - in-vitro, CRC, HT-29 - in-vitro, CRC, DLD1
eff↑, Ki-67↓, Casp3↑, ER Stress↑, ROS↑, BAX↑, XBP-1↑, CHOP↑, eff↑,
1294- And,  5-FU,    Andrographolide reversed 5-FU resistance in human colorectal cancer by elevating BAX expression
- in-vitro, CRC, HCT116
Apoptosis↑, BAX↑,
1350- And,  Cisplatin,    Synergistic antitumor effect of Andrographolide and cisplatin through ROS-mediated ER stress and STAT3 inhibition in colon cancer
- in-vitro, Colon, NA
ChemoSen↑, ER Stress↑, STAT3↓, ROS↑,
1349- And,    Andrographolide promoted ferroptosis to repress the development of non-small cell lung cancer through activation of the mitochondrial dysfunction
- in-vitro, Lung, H460 - in-vitro, Lung, H1650
TumCG↓, TumMeta↓, Ferroptosis↑, ROS↑, MDA↑, Iron↑, GSH↓, GPx4↓, xCT↓, MMP↓, ATP↓,
1347- And,    Suppression of rat neutrophil reactive oxygen species production and adhesion by the diterpenoid lactone andrographolide
- in-vitro, Nor, NA
*ROS↓,
1348- And,    Andrographolide Inhibits ER-Positive Breast Cancer Growth and Enhances Fulvestrant Efficacy via ROS-FOXM1-ER-α Axis
- in-vitro, BC, MCF-7 - in-vitro, BC, T47D - in-vivo, NA, NA
ERα/ESR1↓, TumCG↓, ROS↑, FOXM1↓, eff↑,
6392- ANE,  FEO,    The effect of fennel essential oil and trans-anethole on antibacterial activity of mupirocin against Staphylococcus aureus isolated from asymptomatic carriers
- in-vitro, Nor, NA
*Bacteria↓,
6393- ANE,    Anethole in cancer therapy: Mechanisms, synergistic potential, and clinical challenges
- Review, Var, NA
AntiCan↑, Apoptosis↑, TumCCA↑, TumCP↓, angioG↓, NF-kB↓, PI3K↓, Akt↓, mTOR↓, Casp↓, ChemoSen↑,
6394- ANE,    Anethole blocks both early and late cellular responses transduced by tumor necrosis factor: effect on NF-kappaB, AP-1, JNK, MAPKK and apoptosis
TNF-α↓, NF-kB↓, Casp↑, tumCV↓,
6395- ANE,    Anethole suppressed cell survival and induced apoptosis in human breast cancer cells independent of estrogen receptor status
- in-vitro, BC, MCF-7 - in-vitro, BC, MDA-MB-231
Apoptosis↑, tumCV↓, TumCP↓,
6396- ANE,  FEO,    Anethole Inhibits the Proliferation of Human Prostate Cancer Cells via Induction of Cell Cycle Arrest and Apoptosis
- in-vitro, Pca, PC3
TumCP↓, TumCG↓, TumCMig↓, CSCs↓, ROS↑, MPT↑, Casp3↑, Casp9↑, DNAdam↑, cl‑PARP↑, Bax:Bcl2↑, TumCCA↑, cycD1/CCND1↓, CDK4↓, cMyc↓, P21↑, p27↑, NF-kB↓, eff↑,
6397- ANE,  Cisplatin,    Synergistic Effect of Anethole and Platinum Drug Cisplatin against Oral Cancer Cell Growth and Migration by Inhibiting MAPKase, Beta-Catenin, and NF-κB Pathways
- in-vitro, SCC, Ca9-22
AntiCan↑, ChemoSen↑, TumCP↓, MMP↓, ROS↑, MAPK↓, β-catenin/ZEB1↓, NF-kB↓, EMT↓, Casp↑,
6398- ANE,    trans-Anethole Abrogates Cell Proliferation and Induces Apoptosis through the Mitochondrial-Mediated Pathway in Human Osteosarcoma Cells
- in-vitro, OS, MG63
*Inflam↓, *AntiTum↑, TumCCA↓, ROS↑, MMP↓, Casp3↑, Casp9↑, P53↑, Bcl-xL↓, MPT↑,

Showing Research Papers: 601 to 650 of 6604
Prev Page 13 of 133 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 6604

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

CYP1A1↓, 1,   DJ-1↓, 1,   Ferroptosis↑, 2,   GCLC↑, 1,   GCLM↑, 1,   GPx4↓, 1,   GSH↓, 1,   Iron↑, 1,   MDA↑, 1,   MPO↓, 1,   NOX4↓, 1,   NRF2↑, 1,   ROS↓, 1,   ROS↑, 10,   SOD2↑, 1,   xCT↓, 1,  

Metal & Cofactor Biology ⓘ

FTL↑, 1,   STEAP3↑, 1,  

Mitochondria & Bioenergetics ⓘ

ATP↓, 3,   mitResp↓, 1,   MMP↓, 4,   MPT↑, 2,   OCR↓, 1,   XIAP↓, 1,  

Core Metabolism/Glycolysis ⓘ

ACSL5↑, 2,   p‑AMPK↑, 1,   cMyc↓, 1,   ECAR↑, 1,   i-FASN↓, 1,   GlucoseCon↓, 1,   Glycolysis↓, 2,   lactateProd↓, 1,   SAT1↑, 1,   SIRT1↑, 1,  

Cell Death ⓘ

Akt↓, 2,   p‑Akt↓, 1,   Apoptosis↓, 1,   Apoptosis↑, 10,   Bak↑, 1,   BAX↑, 5,   Bax:Bcl2↑, 2,   Bcl-2↓, 4,   Bcl-xL↓, 1,   Casp↓, 1,   Casp↑, 2,   Casp3↑, 3,   cl‑Casp3↑, 2,   Casp9↑, 3,   cl‑Casp9↑, 1,   Cyt‑c↑, 1,   Ferroptosis↑, 2,   iNOS↓, 1,   lysoMP↑, 1,   MAPK↓, 1,   p‑MAPK↑, 1,   Necroptosis↑, 1,   p27↑, 1,   survivin↓, 1,  

Transcription & Epigenetics ⓘ

HATs↓, 1,   tumCV↓, 4,  

Protein Folding & ER Stress ⓘ

CHOP↑, 1,   ER Stress↑, 2,   HSP70/HSPA5↓, 1,   HSP90↓, 2,   XBP-1↑, 1,  

Autophagy & Lysosomes ⓘ

TumAuto↑, 1,  

DNA Damage & Repair ⓘ

CYP1B1↓, 1,   DNAdam↑, 1,   GADD45A↑, 1,   P53↑, 1,   p‑P53↑, 1,   cl‑PARP↑, 2,   TP53↑, 1,  

Cell Cycle & Senescence ⓘ

CDK1↓, 1,   CDK4↓, 1,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 2,   cycE/CCNE↓, 1,   P21↑, 2,   TumCCA↓, 1,   TumCCA↑, 7,  

Proliferation, Differentiation & Cell State ⓘ

cFos↓, 1,   CREB2↓, 1,   CSCs↓, 1,   EMT↓, 2,   ERK↝, 1,   p‑ERK↓, 1,   FOXM1↓, 1,   FOXO3↑, 1,   Gli1↓, 1,   HDAC↓, 1,   HH↓, 1,   mTOR↓, 2,   PI3K↓, 2,   Smo↓, 1,   STAT3↓, 2,   p‑STAT3↓, 1,   TumCG↓, 4,   Wnt/(β-catenin)↓, 1,  

Migration ⓘ

E-cadherin↓, 1,   FAK↑, 1,   Ki-67↓, 1,   MMP2↓, 3,   MMP9↓, 2,   p‑SMAD2↓, 1,   p‑SMAD3↓, 1,   SMAD4↓, 1,   Snail↑, 1,   TGF-β↓, 1,   TumCI↓, 2,   TumCI↑, 1,   TumCMig↓, 6,   TumCP↓, 12,   TumCP↑, 1,   TumMeta↓, 2,   Twist↑, 1,   ZEB2↑, 1,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 1,   ECM/TCF↓, 1,   EGFR↓, 4,   Hif1a↓, 1,   VEGF↓, 1,  

Barriers & Transport ⓘ

BBB↑, 2,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 2,   IL1↓, 1,   IL6↓, 1,   IL8↓, 1,   LTA/TNF-β↑, 1,   NF-kB↓, 5,   NF-kB↑, 1,   Th1 response↓, 1,   Th2↑, 1,   TNF-α↓, 2,  

Hormonal & Nuclear Receptors ⓘ

ERα/ESR1↓, 2,  

Drug Metabolism & Resistance ⓘ

ChemoSen↑, 6,   Dose↝, 3,   eff↓, 5,   eff↑, 7,   eff↝, 1,   P450↓, 1,  

Clinical Biomarkers ⓘ

Albumin↝, 1,   EGFR↓, 4,   ERα/ESR1↓, 2,   FOXM1↓, 1,   IL6↓, 1,   Ki-67↓, 1,   TP53↑, 1,  

Functional Outcomes ⓘ

AntiCan↑, 2,   AntiTum↑, 1,   chemoPv↑, 1,   OS↑, 3,   TumW↓, 1,  
Total Targets: 153

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↓, 1,   antiOx↑, 1,   Catalase↝, 1,   MDA↓, 1,   ROS↓, 2,   ROS↑, 1,   SOD↝, 1,  

Transcription & Epigenetics ⓘ

other↑, 1,   other↝, 1,  

Proliferation, Differentiation & Cell State ⓘ

EMT↑, 1,  

Migration ⓘ

AntiAg↑, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 1,   NO↓, 1,  

Immune & Inflammatory Signaling ⓘ

Inflam↓, 2,  

Synaptic & Neurotransmission ⓘ

AChE↓, 1,   BDNF↑, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↑, 1,   Dose↝, 1,  

Functional Outcomes ⓘ

AntiTum↑, 1,   cognitive↓, 4,   cognitive↑, 1,   memory↑, 1,   motorD↑, 1,   neuroP↓, 1,   neuroP↑, 1,   Risk↓, 1,   Risk↑, 2,   toxicity↓, 2,  

Infection & Microbiome ⓘ

AntiFungal↑, 1,   Bacteria↓, 2,  
Total Targets: 30

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:%  State#:%  Dir#:%
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