ChemoSen Cancer Research Results

ChemoSen, chemo-sensitization: Click to Expand ⟱
Source:
Type:
The effectiveness of chemotherapy by increasing cancer cell sensitivity to the drugs used to treat them, which is known as “chemo-sensitization”.

Possible Chemo-Sensitizers:
-Curcumin
-Resveratrol
-EGCG
-Quercetin
-Genistein
-Berberine
-Piperine: alkaloid from black pepper
-Ginsenosides: active components of ginseng
-Silymarin
-Allicin
-Lycopene
-Ellagic acid
-Caffeic acid phenethyl ester
-flavopiridol
-oleandrin
-Ursolic acid
-butein
-Betulinic acid
Scientific Papers found: Click to Expand⟱
3079- RES,    Therapeutic role of resveratrol against hepatocellular carcinoma: A review on its molecular mechanisms of action
- Review, Var, NA
angioG↓, TumMeta↓, ChemoSen↑, NADPH↑, SIRT1↑, NF-kB↓, NLRP3↓, Dose↝, COX2/PTGS2↓, MMP9↓, PGE2↓, TIMP1↑, TIMP2↑, Sp1/3/4↓, p‑JNK↓, uPAR↓, ROS↓, CXCR4↓, IL6↓, Gli1↓, *ROS↓, *GSTs↑, *SOD↑, *Catalase↑, *GPx↑, *lipid-P↓, *GSH↑, eff↑, eff↑, eff↑,
3054- RES,    Resveratrol induced reactive oxygen species and endoplasmic reticulum stress-mediated apoptosis, and cell cycle arrest in the A375SM malignant melanoma cell line
- in-vitro, Melanoma, A375
TumCG↓, P21↑, p27/CDKN1B↑, CycB/CCNB1↓, ROS↑, ER Stress↑, p‑p38↑, P53↑, p‑eIF2α↑, EP4/PTGER4↑, CHOP/DDIT3↑, Bcl-2↓, BAX↓, TumCCA↑, NRF2↓, ChemoSen↑, GSH↓,
3055- RES,    Resveratrol and Tumor Microenvironment: Mechanistic Basis and Therapeutic Targets
- Review, Var, NA
BioAv↓, BioAv↓, Dose↑, eff↑, eff↑, Dose↑, BioAv↑, ROS↑, MMP↓, P21↑, p27/CDKN1B↑, TumCCA↑, ChemoSen↑, COX2/PTGS2↓, 5LO↓, VEGF↓, IL1↓, IL6↓, IL8↓, AR↓, PSA↓, MAPK↓, Hif1a↓, Glycolysis↓, miR-21↓, PTEN↑, Half-Life↝, *IGF-1↓, *IGFBP3↑, Half-Life↓,
3063- RES,    Resveratrol: A Review of Pre-clinical Studies for Human Cancer Prevention
- Review, Var, NA
*Inflam↓, *antiOx↑, *AntiAg↑, *chemoPv↑, ChemoSen↑, BioAv↑, Half-Life↝, COX2/PTGS2↓, cycD1/CCND1↓, CDK2↓, CDK4↓, CDK6↓, P21↑, MMP9↓, NF-kB↓, Telomerase↓, PSA↓, MAPK↑, P53↑,
4667- RES,  CUR,  SFN,    Physiological modulation of cancer stem cells by natural compounds: Insights from preclinical models
- Review, Var, NA
CSCs↓, ChemoSen↑, RadioS↑, ALDH↓, CD44↓, Wnt↓, β-catenin/ZEB1↓, NOTCH↓, HH↓, NF-kB↓,
102- RES,    Effect of resveratrol on proliferation and apoptosis of human pancreatic cancer MIA PaCa-2 cells may involve inhibition of the Hedgehog signaling pathway
- in-vitro, PC, MIA PaCa-2
HH↓, PTCH1↓, Smo↓, HH↓, EMT↓, PI3K/Akt↓, NF-kB↓, TumCP↓, Apoptosis↑, ChemoSen↑,
7149- Rhe,    Inhibition of PI3K/AKT signaling via ROS regulation is involved in Rhein-induced apoptosis and enhancement of oxaliplatin sensitivity in pancreatic cancer cells
- in-vitro, PC, NA
TumCCA↑, Casp↑, mt-Apoptosis↑, PI3K↓, Akt↓, ChemoSen↑, ROS↑, eff↓,
1749- RosA,    Rosmarinic Acid and Related Dietary Supplements: Potential Applications in the Prevention and Treatment of Cancer
- Review, Var, NA
antiOx↑, eff↑, *toxicity↝, *BioAv↑, *ROS↓, SOD↑, Catalase↑, GPx↑, lipid-P↓, P450↓, chemoP↑, hepatoP↑, ChemoSen↑,
1747- RosA,    Molecular Pathways of Rosmarinic Acid Anticancer Activity in Triple-Negative Breast Cancer Cells: A Literature Review
- Review, BC, MDA-MB-231 - Review, BC, MDA-MB-468
TumCCA↑, TNF-α↑, GADD45A↑, BNIP3↑, survivin↓, Bcl-2↓, BAX↑, HH↓, eff↑, ChemoSen↑, RadioS↑, TumCP↓, TumCMig↓, Apoptosis↑, RenoP↑, CardioT↓,
1745- RosA,    Rosmarinic acid and its derivatives: Current insights on anticancer potential and other biomedical applications
- Review, Var, NA - Review, AD, NA
ChemoSideEff↓, ChemoSen↑, antiOx↑, MMP2↓, MMP9↓, p‑AMPK↑, DNMTs↓, tumCV↓, COX2/PTGS2↓, E-cadherin↑, Vim↓, N-cadherin↓, EMT↓, Casp3↑, Casp9↓, ROS↓, GSH↑, ERK↓, Akt↓, ROS↓, NF-kB↓, p‑IκB↓, p50↓, p65↓, neuroP↑, Dose↝,
1744- RosA,    Therapeutic Applications of Rosmarinic Acid in Cancer-Chemotherapy-Associated Resistance and Toxicity
- Review, Var, NA
chemoR↓, ChemoSideEff↓, RadioS↑, ROS↓, ChemoSen↑, BioAv↑, Half-Life↝, antiOx↑, ROS↑, Fenton↑, DNAdam↑, Apoptosis↑, CSCs↓, HH↓, Bax:Bcl2↑, MDR1↓, P-gp/ABCB1↓, eff↑, eff↑, FOXO4↑, *eff↑, *ROS↓, *JNK↓, *ERK↓, *GSH↑, *H2O2↑, *MDA↓, *SOD↑, *HO-1↑, *CardioT↓, selectivity↑,
3002- RosA,    Anticancer Effects of Rosemary (Rosmarinus officinalis L.) Extract and Rosemary Extract Polyphenols
- Review, Var, NA
TumCG↓, TumCP↓, TumCCA↑, ChemoSen↑, NRF2↑, PERK↑, SESN2↑, HO-1↑, cl‑Casp3↑, ROS↑, UPR↑, ER Stress↑, CHOP/DDIT3↑, HER2/EBBR2↓, ER-α36↓, PSA↓, BAX↑, AR↓, P-gp/ABCB1↓, Cyt‑c↑, HSP70/HSPA5↑, eff↑, p‑Akt↓, p‑mTOR↓, p‑P70S6K↓, cl‑PARP↑, eff↑,
3001- RosA,    Therapeutic Potential of Rosmarinic Acid: A Comprehensive Review
- Review, Var, NA
TumCP↓, Apoptosis↑, TumMeta↓, Inflam↓, *antiOx↑, *AntiAge↑, *ROS↓, BioAv↑, Dose↝, NRF2↑, P-gp/ABCB1↑, ATP↑, MMPs↓, cl‑PARP↓, Hif1a↓, GlucoseCon↓, lactateProd↓, Warburg↓, TNF-α↓, COX2/PTGS2↓, IL6↓, HDAC2↓, GSH↑, ROS↓, ChemoSen↑, *BG↓, *IL1β↓, *TNF-α↓, *IL6↓, *p‑JNK↓, *p38↓, *Catalase↑, *SOD↑, *GSTs↑, *VitC↑, *VitE↑, *GSH↑, *GutMicro↑, *cardioP↑, *ROS↓, *MMP↓, *lipid-P↓, *NRF2↑, *hepatoP↑, *neuroP↑, *P450↑, *HO-1↑, *AntiAge↑, *motorD↓,
106- RT,    Rutin, a Quercetin Glycoside, Restores Chemosensitivity in Human Breast Cancer Cells
- in-vivo, BC, MCF7
P-gp/ABCB1↓, TumCCA↑, Apoptosis↑, ChemoSen↑,
4898- Sal,    Salinomycin as a potent anticancer stem cell agent: State of the art and future directions
- Review, Var, NA
CSCs↓, AntiCan↑, ChemoSen↑, RadioS↑, Wnt↓, MAPK↓, TumAuto↑, ATP↓, ROS↑, DNAdam↑, ER Stress↑, CSCsMark↓, Iron↑, *toxicity↝,
4900- Sal,    Anticancer Mechanisms of Salinomycin in Breast Cancer and Its Clinical Applications
- Review, BC, NA
CSCs↓, Apoptosis↑, TumAuto↑, necrosis↑, TumCP↓, TumCI↓, TumCMig↓, TumCG↓, TumMeta↓, eff↑, Bcl-2↓, cMyc↓, Snail↓, ALDH↓, Myc↓, AR↓, ROS↑, NF-kB↓, PTCH1↓, Smo↓, Gli1↓, GLI2↓, Wnt↓, mTOR↓, GSK‐3β↓, cycD1/CCND1↓, survivin↓, P21↑, p27/CDKN1B↑, CHOP/DDIT3↑, Ca+2↑, DNAdam↑, Hif1a↓, VEGF↓, angioG↓, MMP↓, ATP↓, p‑P53↑, γH2AX↑, ChemoSen↑,
4902- Sal,  OXA,    Salinomycin and oxaliplatin synergistically enhances cytotoxic effect on human colorectal cancer cells in vitro and in vivo
- vitro+vivo, CRC, NA
RadioS↑, ChemoSen↑, TumCP↓, Apoptosis↑, ROS↑, MMP↓, MAPK↑, eff↓, TumCG↓, TumCCA↑,
4903- Sal,    Salinomycin: A new paradigm in cancer therapy
- Review, Var, NA
TumCG↓, ATP↓, CSCs↓, ROS↑, Casp↑, MMP↓, selectivity↑, OXPHOS↓, STAT3↓, P53↑, γH2AX↑, cycD1/CCND1↓, TumCCA↑, DNAdam↑, ChemoSen↑,
5003- Sal,    Salinomycin, as an autophagy modulator-- a new avenue to anticancer: a review
- Review, Var, NA
CSCs↓, TumAuto↑, selectivity↑, DNAdam↑, TumCCA↑, P-gp/ABCB1↓, Wnt↓, β-catenin/ZEB1↓, RadioS↑, ChemoSen↑, Shh↓, eff↓, ROS↑, AMPK↑, JNK↑, ER Stress↑,
4909- Sal,    Salinomycin: Anti-tumor activity in a pre-clinical colorectal cancer model
- vitro+vivo, CRC, NA
AntiTum↑, Apoptosis↑, mtDam↑, ROS↑, SOD1↓, ChemoSen↑, CSCs↑, ALDH↓, TumCG↓, TumCP↓, TumCD↑, ATP↓,
4910- Sal,    A medicinal chemistry perspective on salinomycin as a potent anticancer and anti-CSCs agent
Apoptosis↑, CSCs↓, ChemoSen↑, RadioS↑, selectivity↑, Wnt↓, toxicity⇅,
5044- SAS,    xCT inhibitor sulfasalazine depletes paclitaxel-resistant tumor cells through ferroptosis in uterine serous carcinoma
- in-vitro, Var, NA
xCT/SLC7A11↓, Ferroptosis↑, ROS↑, IL1↓, IL2↓, NF-kB↓, GSH↓, TumCG↓, ChemoSen↑,
4751- Se,  Chemo,    Selenium Protects Against Toxicity Induced by Anticancer Drugs and Augments Antitumor Activity: A Highly Selective, New, and Novel Approach for the Treatment of Solid Tumors
- in-vivo, Var, NA
Dose↝, ChemoSen↑, chemoP↑,
4725- Se,    Targeting the Nrf2-Prx1 Pathway with Selenium to Enhance the Efficacy and Selectivity of Cancer Therapy
- in-vitro, Lung, A549 - in-vitro, CRC, HT29
AntiCan↑, NRF2↓, Prx↓, ChemoSen↑, *Prx↑, *NRF2↑,
4747- Se,  Chemo,  antiOx,    Phase I trial of selenium plus chemotherapy in gynecologic cancers
- Trial, Ovarian, NA
*toxicity↓, ChemoSen∅, RAD51↓, other↝,
4715- Se,    The Interaction of Selenium with Chemotherapy and Radiation on Normal and Malignant Human Mononuclear Blood Cells
chemoP↑, radioP↑, selectivity↑, ChemoSen↑, GSH↓, *GSH↑, *DNAdam↓, DNAdam↑, eff↑,
4721- SeNPs,    A review on selenium nanoparticles and their biomedical applications
- Review, AD, NA - Review, Diabetic, NA - Review, Arthritis, NA
*antiOx↑, *Inflam↓, *eff↝, *selenoP↑, *Bacteria↓, *neuroP↑, *ROS↓, ChemoSen↑,
4734- SeNPs,  CPT-11,    Cytotoxicity and therapeutic effect of irinotecan combined with selenium nanoparticles
- in-vitro, CRC, HCT8 - in-vivo, NA, NA
chemoP↑, ChemoSen↑, P53↑, Apoptosis↑, TumCG↓, Casp↑, Dose↝, NRF2↓, selectivity↑, *NRF2↑,
4745- SeNPs,  Chemo,    Translational Selenium Nanoparticles Promotes Clinical Non-small-cell Lung Cancer Chemotherapy via Activating Selenoprotein-driven Immune Manipulation
- Study, NSCLC, NA
Risk↓, TumCD↑, mTOR↑, AntiTum↑, ChemoSen↑,
4756- SeNPs,    Selenium‐Containing Nanoparticles Combine the NK Cells Mediated Immunotherapy with Radiotherapy and Chemotherapy
ChemoSen↑, RadioS↓,
4608- SeNPs,    Selenium Nanoparticles for Biomedical Applications: From Development and Characterization to Therapeutics
- Review, Var, NA - NA, AD, NA
*toxicity↝, *toxicity↓, *other↝, ROS↑, *Dose↝, *selenoP↑, AntiCan↑, AntiTum↑, *Bacteria↓, *radioP↑, *BioAv↑, *Inflam↓, *Imm↑, ChemoSen↑, *AntiAg↑, selectivity↑, eff↑, other↝, *eff↑, *Aβ↓, *eff↑,
4504- SeNPs,  Chit,  FA,  doxoR,    pH-responsive selenium nanoparticles stabilized by folate-chitosan delivering doxorubicin for overcoming drug-resistant cancer cells
- in-vitro, Var, NA
ChemoSen↑, Apoptosis↑, Casp3↑, PARP↝,
4469- SeNPs,    Selenium Nanoparticles in Cancer Therapy: Unveiling Cytotoxic Mechanisms and Therapeutic Potential
- Review, Var, NA
antiOx↑, selectivity↑, eff↑, AntiCan↑, Apoptosis↑, ROS↑, MMP↓, Casp3↑, Casp9↑, AntiTum↑, TumCG↓, TumMeta↓, angioG↓, Cyt‑c↑, DNAdam↑, RadioS↑, BBB↑, *toxicity↓, ChemoSen↑,
3183- SFN,    Sulforaphane potentiates the efficacy of chemoradiotherapy in glioblastoma by selectively targeting thioredoxin reductase 1
- in-vitro, GBM, NA
RadioS↑, TrxR1↓, ROS↑, ChemoSen↑, Prx↓,
2553- SFN,    Mechanistic review of sulforaphane as a chemoprotective agent in bladder cancer
- Review, Bladder, NA
antiOx↓, Inflam↓, ChemoSen↑, ROS⇅, *NRF2↑, *GSH↑, Catalase↑, HO-1↑, NAD↑, chemoP↑,
2448- SFN,    Sulforaphane and bladder cancer: a potential novel antitumor compound
- Review, Bladder, NA
Apoptosis↑, TumCG↓, TumCI↓, TumMeta↓, glucoNG↓, ChemoSen↑, TumCCA↑, Casp3↑, Casp7↑, cl‑PARP↑, survivin↓, EGFR↓, HER2/EBBR2↓, ATP↓, Glycolysis↓, mt-OXPHOS↓, AKT1↓, HK2↓, Hif1a↓, ROS↑, NRF2↑, EMT↓, COX2/PTGS2↓, MMP2↓, MMP9↓, Zeb1↓, Snail↓, HDAC↓, HATs↓, MMP↓, Cyt‑c↓, Shh↓, Smo↓, Gli1↓, BioAv↝, BioAv↝, Dose↝,
1458- SFN,    Sulforaphane Impact on Reactive Oxygen Species (ROS) in Bladder Carcinoma
- Review, Bladder, NA
HDAC↓, eff↓, TumW↓, TumW↓, angioG↓, *toxicity↓, GutMicro↝, AntiCan↑, ROS↑, MMP↓, Cyt‑c↑, Bax:Bcl2↑, Casp3↑, Casp9↑, Casp8∅, cl‑PARP↑, TRAIL↑, DR5↑, eff↓, NRF2↑, ER Stress↑, COX2/PTGS2↓, EGFR↓, HER2/EBBR2↓, ChemoSen↑, NF-kB↓, TumCCA?, p‑Akt↓, p‑mTOR↓, p70S6↓, p19↑, P21↑, CD44↓, CSCs↓,
1436- SFN,  PacT,  docx,    Sulforaphane enhances the anticancer activity of taxanes against triple negative breast cancer by killing cancer stem cells
- in-vivo, BC, SUM159
NF-kB↓, ChemoSen↑, IL6↓, IL8↑,
1434- SFN,  GEM,    Sulforaphane Potentiates Gemcitabine-Mediated Anti-Cancer Effects against Intrahepatic Cholangiocarcinoma by Inhibiting HDAC Activity
- in-vitro, CCA, HuCCT1 - in-vitro, CCA, HuH28 - in-vivo, NA, NA
HDAC↓, ac‑H3↑, ChemoSen↑, tumCV↓, TumCP↓, TumCCA↑, Apoptosis↑, cl‑Casp3↑, TumCI↓, VEGF↓, VEGFR2/KDR/Flk1↓, Hif1a↓, eNOS↓, EMT?, TumCG↓, Ki-67↓, TUNEL↑, P21↑, p‑Chk2↑, CDC25↓, BAX↑, *ROS↓, NQO1?,
1474- SFN,    Sulforaphane induces p53‑deficient SW480 cell apoptosis via the ROS‑MAPK signaling pathway
- in-vitro, Colon, SW480
TumCG↓, Apoptosis↑, MMP↓, Bax:Bcl2↑, Casp3↑, Casp7↑, Casp9↑, ROS↑, e-ERK↑, p38↑, P53∅, eff↓, ChemoSen↑,
1484- SFN,    Sulforaphane’s Multifaceted Potential: From Neuroprotection to Anticancer Action
- Review, Var, NA - Review, AD, NA
neuroP↑, AntiCan↑, NRF2↑, HDAC↓, eff↑, *ROS↓, neuroP↑, HDAC↓, *toxicity∅, BioAv↑, eff↓, cycD1/CCND1↓, CDK4↓, p‑RB1↓, Glycolysis↓, miR-30a-5p↑, TumCCA↑, TumCG↓, TumMeta↓, eff↑, ChemoSen↑, RadioS↑, CardioT↓, angioG↓, Hif1a↓, VEGF↓, *BioAv?, *Half-Life∅,
1481- SFN,  docx,    Combination of Low-Dose Sulforaphane and Docetaxel on Mitochondrial Function and Metabolic Reprogramming in Prostate Cancer Cell Lines
- in-vitro, Pca, LNCaP - in-vitro, Pca, PC3
ChemoSen↑, Casp3↑, ROS↑, Casp8↑, Cyt‑c↑, Glycolysis↓, GSH↓, GSH/GSSG↓, *toxicity↓,
1730- SFN,    Sulforaphane: An emergent anti-cancer stem cell agent
- Review, Var, NA
BioAv↓, BioAv↑, GSTA1↑, P450↓, TumCCA↑, HDAC↓, P21↑, p27/CDKN1B↑, DNMT1↓, DNMT3A↓, cycD1/CCND1↑, DNAdam↑, BAX↑, Cyt‑c↑, Apoptosis↑, ROS↑, AIF↑, CDK1↑, Casp3↑, Casp8↑, Casp9↑, NRF2↑, NF-kB↓, TNF-α↓, IL1β↓, CSCs↓, CD133↓, CD44↓, ALDH↓, Nanog↓, OCT4↓, hTERT/TERT↓, MMP2↓, EMT↓, ALDH1A1↓, Wnt↓, NOTCH↓, ChemoSen↑, *Ki-67↓, *HDAC3↓, *HDAC↓,
1731- SFN,    Targeting cancer stem cells with sulforaphane, a dietary component from broccoli and broccoli sprouts
- Review, Var, NA
CSCs↓, ChemoSen↑, NF-kB↓, Shh↓, Smo↓, Gli1↓, GLI2↓, PI3K↓, Wnt↓, β-catenin/ZEB1↓, Nanog↓, COX2/PTGS2↓, Zeb1↓, Snail↓, ChemoSideEff↓, eff↑, *BioAv↑,
1722- SFN,    Sulforaphane as an anticancer molecule: mechanisms of action, synergistic effects, enhancement of drug safety, and delivery systems
- Review, Var, NA
TumCCA↑, CYP1A1↓, CYP3A4↓, Cyt‑c↑, Casp9↑, Apoptosis↑, ROS↑, MAPK↑, P53↑, BAX↑, ChemoSen↑, HDAC↓, GSH↓, HO-1↑,
3300- SIL,    Toward the definition of the mechanism of action of silymarin: activities related to cellular protection from toxic damage induced by chemotherapy
- Review, Var, NA
*ROS↓, *SOD↑, *hepatoP↑, *AST↓, *ALAT↓, *lipid-P↓, *GSH↑, *Catalase↑, *GSTs↑, *GSR↑, *TNF-α↓, *IFN-γ↓, *IL4↓, *IL2↓, *NF-kB↓, *IL10↑, *Inflam↓, COX2/PTGS2↓, Apoptosis↑, ChemoSen↑, PGE2↓, VEGF↓,
3326- SIL,    Silymarin suppresses proliferation of human hepatocellular carcinoma cells under hypoxia through downregulation of the HIF-1α/VEGF pathway
- in-vitro, Liver, HepG2 - in-vitro, Liver, Hep3B
*hepatoP↑, chemoPv↑, ChemoSen↑, TumCP↓, TumCMig↓, TumCI↓, Hif1a↓, VEGF↓, angioG↓,
1316- SIL,  Chemo,    Silymarin and Cancer: A Dual Strategy in Both in Chemoprevention and Chemosensitivity
- Analysis, Var, NA
TumCCA↑, p42↓, P450↓, OATPs↓, chemoP↑, ChemoSen↑,
2418- SK,    Experimental Study of Hepatocellular Carcinoma Treatment by Shikonin Through Regulating PKM2
- in-vitro, HCC, SMMC-7721 cell - in-vitro, HCC, HUH7 - in-vitro, HCC, HepG2
tumCV↓, GlucoseCon↓, lactateProd↓, ChemoSen↑, PKM2↓, Glycolysis↓,
2196- SK,    Research progress in mechanism of anticancer action of shikonin targeting reactive oxygen species
- Review, Var, NA
*ALAT↓, *AST↓, *Inflam?, *EMT↑, ROS?, TrxR1↓, PERK↑, eIF2α↑, ATF4↑, CHOP/DDIT3↑, IRE1↑, JNK↑, eff↝, DR5↑, Glycolysis↓, PKM2↓, ChemoSen↑, GPx4↓, HO-1↑,

Showing Research Papers: 601 to 650 of 705
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 705

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 4,   Catalase↑, 2,   CYP1A1↓, 1,   Fenton↑, 1,   Ferroptosis↑, 1,   GPx↑, 1,   GPx4↓, 1,   GSH↓, 5,   GSH↑, 2,   GSH/GSSG↓, 1,   GSTA1↑, 1,   HO-1↑, 4,   Iron↑, 1,   lipid-P↓, 1,   NQO1?, 1,   NRF2↓, 3,   NRF2↑, 6,   OXPHOS↓, 1,   mt-OXPHOS↓, 1,   Prx↓, 2,   ROS?, 1,   ROS↓, 5,   ROS↑, 21,   ROS⇅, 1,   SOD↑, 1,   SOD1↓, 1,   TrxR1↓, 2,   xCT/SLC7A11↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

AIF↑, 1,   ATP↓, 5,   ATP↑, 1,   CDC25↓, 1,   MMP↓, 8,   mtDam↑, 1,   p42↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AKT1↓, 1,   AMPK↑, 1,   p‑AMPK↑, 1,   cMyc↓, 1,   CYP3A4↓, 1,   glucoNG↓, 1,   GlucoseCon↓, 2,   Glycolysis↓, 6,   HK2↓, 1,   lactateProd↓, 2,   NAD↑, 1,   NADPH↑, 1,   PI3K/Akt↓, 1,   PKM2↓, 2,   SIRT1↑, 1,   Warburg↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 2,   p‑Akt↓, 2,   Apoptosis↑, 18,   mt-Apoptosis↑, 1,   BAX↓, 1,   BAX↑, 5,   Bax:Bcl2↑, 3,   Bcl-2↓, 3,   Casp↑, 3,   Casp3↑, 8,   cl‑Casp3↑, 2,   Casp7↑, 2,   Casp8↑, 2,   Casp8∅, 1,   Casp9↓, 1,   Casp9↑, 5,   p‑Chk2↑, 1,   Cyt‑c↓, 1,   Cyt‑c↑, 6,   DR5↑, 2,   Ferroptosis↑, 1,   hTERT/TERT↓, 1,   JNK↑, 2,   p‑JNK↓, 1,   MAPK↓, 2,   MAPK↑, 3,   Myc↓, 1,   necrosis↑, 1,   p27/CDKN1B↑, 4,   p38↑, 1,   p‑p38↑, 1,   survivin↓, 3,   Telomerase↓, 1,   TRAIL↑, 1,   TumCD↑, 2,   TUNEL↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

HER2/EBBR2↓, 3,   p70S6↓, 1,   Sp1/3/4↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ac‑H3↑, 1,   HATs↓, 1,   miR-21↓, 1,   miR-30a-5p↑, 1,   other↝, 2,   tumCV↓, 3,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 4,   eIF2α↑, 1,   p‑eIF2α↑, 1,   ER Stress↑, 5,   HSP70/HSPA5↑, 1,   IRE1↑, 1,   PERK↑, 2,   UPR↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

BNIP3↑, 1,   SESN2↑, 1,   TumAuto↑, 3,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 8,   DNMT1↓, 1,   DNMT3A↓, 1,   DNMTs↓, 1,   GADD45A↑, 1,   P53↑, 5,   P53∅, 1,   p‑P53↑, 1,   PARP↝, 1,   cl‑PARP↓, 1,   cl‑PARP↑, 3,   RAD51↓, 1,   γH2AX↑, 2,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↑, 1,   CDK2↓, 1,   CDK4↓, 2,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 4,   cycD1/CCND1↑, 1,   p19↑, 1,   P21↑, 7,   p‑RB1↓, 1,   TumCCA?, 1,   TumCCA↑, 15,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 4,   ALDH1A1↓, 1,   CD133↓, 1,   CD44↓, 3,   CSCs↓, 10,   CSCs↑, 1,   CSCsMark↓, 1,   EMT?, 1,   EMT↓, 4,   EP4/PTGER4↑, 1,   ERK↓, 1,   e-ERK↑, 1,   FOXO4↑, 1,   Gli1↓, 4,   GSK‐3β↓, 1,   HDAC↓, 7,   HDAC2↓, 1,   HH↓, 5,   mTOR↓, 1,   mTOR↑, 1,   p‑mTOR↓, 2,   Nanog↓, 2,   NOTCH↓, 2,   OCT4↓, 1,   p‑P70S6K↓, 1,   PI3K↓, 2,   PTCH1↓, 2,   PTEN↑, 1,   Shh↓, 3,   Smo↓, 4,   STAT3↓, 1,   TumCG↓, 13,   Wnt↓, 7,  

Migration(tgid=13) ⓘ

5LO↓, 1,   Ca+2↑, 1,   E-cadherin↑, 1,   ER-α36↓, 1,   GLI2↓, 2,   Ki-67↓, 1,   MMP2↓, 3,   MMP9↓, 4,   MMPs↓, 1,   N-cadherin↓, 1,   Snail↓, 3,   TIMP1↑, 1,   TIMP2↑, 1,   TumCI↓, 4,   TumCMig↓, 3,   TumCP↓, 9,   TumMeta↓, 6,   uPAR↓, 1,   Vim↓, 1,   Zeb1↓, 2,   β-catenin/ZEB1↓, 3,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 6,   ATF4↑, 1,   EGFR↓, 2,   eNOS↓, 1,   Hif1a↓, 7,   VEGF↓, 6,   VEGFR2/KDR/Flk1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   OATPs↓, 1,   P-gp/ABCB1↓, 4,   P-gp/ABCB1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 9,   CXCR4↓, 1,   IL1↓, 2,   IL1β↓, 1,   IL2↓, 1,   IL6↓, 4,   IL8↓, 1,   IL8↑, 1,   Inflam↓, 2,   p‑IκB↓, 1,   NF-kB↓, 11,   p50↓, 1,   p65↓, 1,   PGE2↓, 2,   PSA↓, 3,   TNF-α↓, 2,   TNF-α↑, 1,  

Protein Aggregation(tgid=19) ⓘ

NLRP3↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 3,   CDK6↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 3,   BioAv↑, 6,   BioAv↝, 2,   chemoR↓, 1,   ChemoSen↑, 49,   ChemoSen∅, 1,   Dose↑, 2,   Dose↝, 6,   eff↓, 7,   eff↑, 18,   eff↝, 1,   Half-Life↓, 1,   Half-Life↝, 3,   MDR1↓, 1,   P450↓, 3,   RadioS↓, 1,   RadioS↑, 10,   selectivity↑, 8,  

Clinical Biomarkers(tgid=22) ⓘ

AR↓, 3,   EGFR↓, 2,   GutMicro↝, 1,   HER2/EBBR2↓, 3,   hTERT/TERT↓, 1,   IL6↓, 4,   Ki-67↓, 1,   Myc↓, 1,   PSA↓, 3,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 6,   AntiTum↑, 4,   CardioT↓, 2,   chemoP↑, 6,   chemoPv↑, 1,   ChemoSideEff↓, 3,   hepatoP↑, 1,   neuroP↑, 3,   radioP↑, 1,   RenoP↑, 1,   Risk↓, 1,   toxicity⇅, 1,   TumW↓, 2,  
Total Targets: 257

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 3,   Catalase↑, 3,   GPx↑, 1,   GSH↑, 6,   GSR↑, 1,   GSTs↑, 3,   H2O2↑, 1,   HO-1↑, 2,   lipid-P↓, 3,   MDA↓, 1,   NRF2↑, 4,   Prx↑, 1,   ROS↓, 9,   selenoP↑, 2,   SOD↑, 4,   VitC↑, 1,   VitE↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

MMP↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 2,  

Cell Death(tgid=5) ⓘ

JNK↓, 1,   p‑JNK↓, 1,   p38↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↝, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

EMT↑, 1,   ERK↓, 1,   HDAC↓, 1,   HDAC3↓, 1,   IGF-1↓, 1,   IGFBP3↑, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 2,   Ki-67↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

IFN-γ↓, 1,   IL10↑, 1,   IL1β↓, 1,   IL2↓, 1,   IL4↓, 1,   IL6↓, 1,   Imm↑, 1,   Inflam?, 1,   Inflam↓, 4,   NF-kB↓, 1,   TNF-α↓, 2,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv?, 1,   BioAv↑, 3,   Dose↝, 1,   eff↑, 3,   eff↝, 1,   Half-Life∅, 1,   P450↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 2,   AST↓, 2,   BG↓, 1,   GutMicro↑, 1,   IL6↓, 1,   Ki-67↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 2,   cardioP↑, 1,   CardioT↓, 1,   chemoPv↑, 1,   hepatoP↑, 3,   motorD↓, 1,   neuroP↑, 2,   radioP↑, 1,   toxicity↓, 5,   toxicity↝, 3,   toxicity∅, 1,  

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 2,  
Total Targets: 69

Scientific Paper Hit Count for: ChemoSen, chemo-sensitization
38 Chemotherapy
33 Cisplatin
29 Curcumin
21 doxorubicin
17 Resveratrol
15 Thymoquinone
13 5-fluorouracil
13 Artemisinin
13 Baicalein
13 Betulinic acid
13 Quercetin
13 Eugenol
13 Sulforaphane (mainly Broccoli)
12 Apigenin (mainly Parsley)
12 Chrysin
12 Fisetin
12 Magnetic Fields
11 Capsaicin
11 Honokiol
10 Vitamin C (Ascorbic Acid)
10 Docetaxel
10 Propolis -bee glue
10 diet FMD Fasting Mimicking Diet
10 Gambogic Acid
10 Lycopene
9 Radiotherapy/Radiation
9 IP6 (Inositol 1,2,3,4,5,6-hexakisphosphate)
8 Luteolin
8 brusatol
8 Boswellia (frankincense)
8 Selenium NanoParticles
8 salinomycin
8 diet Methionine-Restricted Diet
8 Formononetin
8 Shikonin
7 Sorafenib (brand name Nexavar)
7 Astragalus
7 Copper and Cu NanoParticles
7 Ashwagandha(Withaferin A)
7 Berberine
7 Disulfiram
7 EGCG (Epigallocatechin Gallate)
7 Emodin
7 Paclitaxel/Taxol
7 Pterostilbene
7 Selenite (Sodium)
7 Vitamin K2
6 Allicin (mainly Garlic)
6 Gemcitabine (Gemzar)
6 borneol
6 chitosan
6 Fucoidan
6 Metformin
6 Phenethyl isothiocyanate
6 Rosmarinic acid
5 2-DeoxyGlucose
5 Silver-NanoParticles
5 Anti-oxidants
5 Selenium
5 Astaxanthin
5 Atorvastatin
5 Beta-Caryophyllene
5 Cinnamon
5 Citric Acid
5 Coenzyme Q10
5 Crocetin
5 Docosahexaenoic Acid
5 diet Short Term Fasting
5 Hydrogen Gas
5 Inositol
5 Melatonin
5 Piperlongumine
5 VitK3,menadione
5 Urolithin
4 Alpha-Lipoic-Acid
4 Caffeic acid
4 Caffeic Acid Phenethyl Ester (CAPE)
4 Chlorogenic acid
4 Cucurbitacin
4 Oxygen, Hyperbaric
4 Dandelion Root
4 Ellagic acid
4 Hyperthermia
4 Indole-3-carbinol
4 isoorientin
4 Magnolol
3 Auranofin
3 Andrographis
3 Isovitexin
3 beta-glucans
3 immunotherapy
3 Baicalin
3 Berbamine
3 Brucea javanica
3 Piperine
3 Carvacrol
3 Celastrol
3 Hydroxycinnamic-acid
3 Dichloroacetate
3 Electrical Pulses
3 Gallic acid
3 Garcinol
3 Ginkgetin
3 Gossypol/AT-101
3 HydroxyCitric Acid
3 isoflavones
3 Bicarbonate(Sodium)
3 Phenylbutyrate
3 Silymarin (Milk Thistle) silibinin
2 3-bromopyruvate
2 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
2 Anethole/trans-Anethole
2 Biochanin A
2 Bromelain
2 Boron
2 erastin
2 Carnosic acid
2 Trastuzumab
2 Thymol-Thymus vulgaris
2 Cat’s Claw
2 Cannabidiol
2 chemodynamic therapy
2 Celecoxib
2 Folic Acid, Vit B9
2 Chlorophyllin
2 Calorie Restriction Mimetics
2 Carvone
2 Cynaropicrin
2 Diclofenac
2 D-limonene
2 Exercise
2 Shilajit/Fulvic Acid
2 Ginkgo biloba
2 Genistein (soy isoflavone)
2 Geraniol
2 Ginkgolide B
2 Ginseng
2 tamoxifen
2 Spermidine
2 iodine
2 Isoliquiritigenin
2 Naringin
2 Niclosamide (Niclocide)
2 Plumbagin
2 Psoralidin
2 Oxaliplatin
2 Terpinen-4-ol / Tea Tree Oil
1 Gold NanoParticles
1 Photodynamic Therapy
1 Amodiaquine
1 Vitamin A, Retinoic Acid
1 temozolomide
1 Aspirin
1 Dipyridamole
1 Aloe anthraquinones
1 epirubicin
1 Lapatinib
1 Ras-selective lethal 3
1 Butyrate
1 urea
1 Centella asiatica / Gotu kola → asiaticoside
1 Vitamin E
1 Cynara scolymus/Globe Artichoke/Artichoke Extract
1 Cyclopamine
1 Deguelin
1 diet Ketogenic
1 Lemongrass Extract/Citral
1 Zinc
1 Echinacea
1 Ginkgo biloba-EGb 761
1 Eurycomanone
1 Evodiamine
1 Ferulic acid
1 Fenbendazole
1 Ginkgolic acids
1 Ginger/6-Shogaol/Gingerol
1 γ-linolenic acid (Borage Oil)
1 Graviola
1 hydrogen sulfide
1 Hibiscus sabdariffa
1 HydroxyTyrosol
1 Hyperoside
1 metronomic chemo
1 capecitabine
1 Linalool
1 Bortezomib
1 carboplatin
1 Moringa oleifera
1 Mushroom Reishi
1 Nimbolide
1 nelfinavir/Viracept
1 Proanthocyanidins
1 SonoDynamic Therapy UltraSound
1 Propyl gallate
1 Ramucirumab (CYRAMZA)
1 Rhein
1 Rutin
1 Sulfasalazine
1 irinotecan
1 cetuximab
1 Aflavin-3,3′-digallate
1 Vitamin D3
1 Vitexin
1 Zerumbone
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1106  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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