selectivity Cancer Research Results

selectivity, selectivity: Click to Expand ⟱
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The selectivity of cancer products (such as chemotherapeutic agents, targeted therapies, immunotherapies, and novel cancer drugs) refers to their ability to affect cancer cells preferentially over normal, healthy cells. High selectivity is important because it can lead to better patient outcomes by reducing side effects and minimizing damage to normal tissues.

Achieving high selectivity in cancer treatment is crucial for improving patient outcomes. It relies on pinpointing molecular differences between cancerous and normal cells, designing drugs or delivery systems that exploit these differences, and overcoming intrinsic challenges like tumor heterogeneity and resistance

Factors that affect selectivity:
1. Ability of Cancer cells to preferentially absorb a product/drug
-EPR-enhanced permeability and retention of cancer cells
-nanoparticle formations/carriers may target cancer cells over normal cells
-Liposomal formations. Also negatively/positively charged affects absorbtion

2. Product/drug effect may be different for normal vs cancer cells
- hypoxia
- transition metal content levels (iron/copper) change probability of fenton reaction.
- pH levels
- antiOxidant levels and defense levels

3. Bio-availability
Scientific Papers found: Click to Expand⟱
4448- SeNPs,    Selenium Nanoparticles: A Comprehensive Examination of Synthesis Techniques and Their Diverse Applications in Medical Research and Toxicology Studies
- Review, Nor, NA
*toxicity↓, *toxicity↓, selectivity↑, *antiOx↑, *cognitive↑, *other↝, TumCCA↑,
4473- SeNPs,    Anti-cancerous effect and biological evaluation of green synthesized Selenium nanoparticles on MCF-7 breast cancer and HUVEC cell lines
- in-vitro, BC, MCF7 - in-vitro, Nor, HUVECs
AntiCan↑, selectivity↓, *Bacteria↓, *antiOx↑, *toxicity↓, ROS↑, tumCV↓,
4472- SeNPs,    Therapeutic potential of selenium nanoparticles
- Review, Var, NA
*ROS↓, *BioAv↑, *antiOx↑, toxicity↓, eff↑, *other↝, EPR↑, selectivity↑, eff↑, RadioS↑, eff↑, *Bacteria↓,
4471- SeNPs,    Green synthesis of selenium nanoparticles with extract of hawthorn fruit induced HepG2 cells apoptosis
- in-vitro, Liver, HepG2
eff↑, ROS↑, MMP↓, Casp9↑, Bcl-2↓, selectivity↑, Apoptosis↑,
4469- SeNPs,    Selenium Nanoparticles in Cancer Therapy: Unveiling Cytotoxic Mechanisms and Therapeutic Potential
- Review, Var, NA
antiOx↑, selectivity↑, eff↑, AntiCan↑, Apoptosis↑, ROS↑, MMP↓, Casp3↑, Casp9↑, AntiTum↑, TumCG↓, TumMeta↓, angioG↓, Cyt‑c↑, DNAdam↑, RadioS↑, BBB↑, *toxicity↓, ChemoSen↑,
4449- SeNPs,    PEG-nanolized ultrasmall selenium nanoparticles overcome drug resistance in hepatocellular carcinoma HepG2 cells through induction of mitochondria dysfunction
- in-vitro, Liver, HepG2
MMP↓, selectivity↑, Apoptosis↑, ROS↑,
4453- SeNPs,    Selenium Nanoparticles: Green Synthesis and Biomedical Application
- Review, Var, NA
*toxicity↓, *Bacteria↓, ROS↑, MMP↓, ER Stress↑, P53↑, Apoptosis↑, Casp9↑, DNAdam↑, TumCCA↑, eff↑, Catalase↓, SOD↓, GSH↓, selectivity↓, selectivity↑, PCNA↓, eff↑, *ALAT↓, *AST↓, *ALP↓, *creat↓, *Inflam↓, *toxicity↓, selectivity↑,
4457- SeNPs,    Selenium nanoparticles: a review on synthesis and biomedical applications
- Review, Var, NA - NA, Diabetic, NA
*BioAv↑, *toxicity↓, *eff↑, chemoPv↑, *Inflam↓, antiOx↑, *selenoP↑, *ROS↓, *Dose↝, AntiCan↑, *Bacteria↓, eff↑, DNAdam↑, selectivity↑, *AntiDiabetic↑,
3192- SFN,    Transcriptome analysis reveals a dynamic and differential transcriptional response to sulforaphane in normal and prostate cancer cells and suggests a role for Sp1 in chemoprevention
- in-vitro, Pca, PC3
Sp1/3/4↓, selectivity↑, NRF2↑, HDAC↓, DNMTs↓, TumCCA↑, selectivity↑, HO-1↑, NQO1↑, CDK2↓, TumCP↓, BID↑, Smad1↑, Diablo↑, ICAD↑, Cyt‑c↑, IAP1↑, HSP27↑, *Cyt‑c↓, *IAP1↓, *HSP27↓, survivin↓, CDK4↓, VEGF↓, AR↓,
3182- SFN,    Sulforaphane Modulates AQP8-Linked Redox Signalling in Leukemia Cells
- in-vitro, AML, NA
Prx↓, AQPs↓, NOX↓, tumCV↓, AntiCan↑, cardioP↑, neuroP↑, Inflam↓, chemoPv↑, angioG↓, TumMeta↓, selectivity↑, ROS↓,
2166- SFN,    Sulforaphane targets cancer stemness and tumor initiating properties in oral squamous cell carcinomas via miR-200c induction
- in-vitro, Oral, NA - in-vivo, NA, NA
CSCs↓, selectivity↑, TumCMig↓, TumCI↓,
1498- SFN,    Prolonged sulforaphane treatment activates survival signaling in nontumorigenic NCM460 colon cells but apoptotic signaling in tumorigenic HCT116 colon cells
- in-vitro, CRC, HCT116 - in-vitro, Nor, NCM460
selectivity↑, TumCCA↑, Apoptosis↑, *p‑ERK↑, cMYB↓, selectivity↑, selectivity↑,
1502- SFN,    Epigenetic targets of bioactive dietary components for cancer prevention and therapy
- Review, Var, NA
HDAC↓, AntiCan↑, DNMTs↓, hTERT/TERT↓, selectivity↑,
1497- SFN,    Differential effects of sulforaphane on histone deacetylases, cell cycle arrest and apoptosis in normal prostate cells versus hyperplastic and cancerous prostate cells
- in-vitro, Nor, PrEC - in-vitro, Pca, LNCaP - in-vitro, Pca, PC3
HDAC↓, selectivity↑, TumCCA↑, Apoptosis↑, selectivity↑, H3↑, P21↑, selectivity↑,
1494- SFN,  doxoR,    Sulforaphane potentiates anticancer effects of doxorubicin and attenuates its cardiotoxicity in a breast cancer model
- in-vivo, BC, NA - in-vitro, BC, MCF7 - in-vitro, Nor, MCF10
CardioT↓, *GSH↑, *ROS↓, *NRF2↑, NRF2∅, HDAC↓, DNMTs↓, Casp3↑, ER-α36↓, Remission↑, ChemoSen↑, ROS↑, selectivity?,
1736- SFN,    Antitumor and antimetastatic effects of dietary sulforaphane in a triple-negative breast cancer models
- in-vitro, BC, NA - in-vivo, BC, NA
TumCG↓, selectivity↓,
1734- SFN,    Sulforaphane Inhibits Nonmuscle Invasive Bladder Cancer Cells Proliferation through Suppression of HIF-1α-Mediated Glycolysis in Hypoxia
- in-vitro, Bladder, RT112
selectivity↑, TumCP↓, Glycolysis↓, Hif1a↓,
3299- SIL,    Silymarin Effect on Mitophagy Pathway in the Human Colon Cancer HT-29 Cells
- in-vitro, Colon, HT29
tumCV↓, MMP↓, ROS↑, selectivity↑,
3282- SIL,    Role of Silymarin in Cancer Treatment: Facts, Hypotheses, and Questions
- Review, Var, NA
hepatoP↑, AntiCan↑, TumCMig↓, Hif1a↓, selectivity↑, toxicity∅, *antiOx↑, *Inflam↓, TumCCA↑, P21↑, CDK4↓, NF-kB↓, ERK↓, PSA↓, TumCG↓, p27/CDKN1B↑, COX2/PTGS2↓, IL1↓, VEGF↓, IGFBP3↑, AR↓, STAT3↓, Telomerase↓, Cyt‑c↑, Casp↑, eff↝, HDAC↓, HATs↑, Zeb1↓, E-cadherin↑, miR-203↑, NHE1↓, MMP2↓, MMP9↓, PGE2↓, Vim↓, Wnt↓, angioG↓, VEGF↓, *TIMP1↓, EMT↓, TGF-β↓, CD44↓, EGFR↓, PDGF↓, *IL8↓, SREBP1/SREBF1↓, MMP↓, ATP↓, uPA↓, PD-L1↓, NOTCH↓, *SIRT1↑, SIRT1↓, CA↓, Ca+2↑, chemoP↑, cardioP↑, Dose↝, Half-Life↝, BioAv↓, BioAv↓, BioAv↓, toxicity↝, Half-Life↓, ROS↓, FAK↓,
977- SK,    A novel antiestrogen agent Shikonin inhibits estrogen-dependent gene transcription in human breast cancer cells
- in-vitro, BC, T47D - in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF7 - in-vitro, Nor, HMEC
TumCG↓, ERα/ESR1↓, selectivity↑, *toxicity↓,
2008- SK,  Cisplatin,    Enhancement of cisplatin-induced colon cancer cells apoptosis by shikonin, a natural inducer of ROS in vitro and in vivo
- in-vitro, CRC, HCT116 - in-vivo, NA, NA
ChemoSen↑, selectivity↑, i-ROS↑, DNAdam↑, MMP↓, TumCCA↑, eff↓, *toxicity↓,
2010- SK,    Shikonin inhibits gefitinib-resistant non-small cell lung cancer by inhibiting TrxR and activating the EGFR proteasomal degradation pathway
- in-vitro, Lung, H1975 - in-vitro, Lung, H1650 - in-vitro, Nor, CCD19
EGFR↓, selectivity↑, Casp↑, PARP↑, Apoptosis↑, ROS↑, eff↓, selectivity↑,
2007- SK,    Shikonin Directly Targets Mitochondria and Causes Mitochondrial Dysfunction in Cancer Cells
- in-vitro, lymphoma, U937 - in-vitro, BC, MCF7 - in-vitro, BC, SkBr3 - in-vitro, CRC, HCT116 - in-vitro, OS, U2OS - NA, Nor, RPE-1
tumCV↓, selectivity↑, Dose↝, other↑, MMP↓, ROS↑, DNAdam↑, Ca+2↑, Casp9↑, Cyt‑c↑, *toxicity↓,
2009- SK,    Necroptosis inhibits autophagy by regulating the formation of RIP3/p62/Keap1 complex in shikonin-induced ROS dependent cell death of human bladder cancer
- in-vitro, Bladder, NA
TumCG↓, selectivity↑, *toxicity∅, Necroptosis↑, ROS↑, p62↑, Keap1↑, *NRF2↑, Synergy↑,
2230- SK,    Shikonin induces ROS-based mitochondria-mediated apoptosis in colon cancer
- in-vitro, CRC, HCT116 - in-vivo, NA, NA
TumCG↓, Bcl-2↓, ROS↑, Bcl-xL↓, MMP↓, Casp↑, selectivity↑, cycD1/CCND1↓, TumCCA↑, eff↓,
2185- SK,    Shikonin Inhibits Tumor Growth in Mice by Suppressing Pyruvate Kinase M2-mediated Aerobic Glycolysis
- in-vitro, Lung, LLC1 - in-vitro, Melanoma, B16-BL6 - in-vivo, NA, NA
Glycolysis↓, GlucoseCon↓, lactateProd↓, PKM2↓, selectivity↑, Warburg↓, TumVol↓, TumW↓,
2227- SK,    Shikonin induces mitochondria-mediated apoptosis and enhances chemotherapeutic sensitivity of gastric cancer through reactive oxygen species
- in-vitro, GC, BGC-823 - in-vitro, GC, SGC-7901 - in-vitro, Nor, GES-1
selectivity↑, TumCP↓, TumCD↑, ROS↑, MMP↓, Casp↑, Cyt‑c↑, Endon↑, AIF↑, eff↓, ChemoSen↑, TumCCA↑, GSH/GSSG↓, lipid-P↑,
2226- SK,    Shikonin, a Chinese plant-derived naphthoquinone, induces apoptosis in hepatocellular carcinoma cells through reactive oxygen species: A potential new treatment for hepatocellular carcinoma
- in-vitro, HCC, HUH7 - in-vitro, HCC, Bel-7402
selectivity↑, ROS↑, eff↓, Akt↓, RIP1↓, NF-kB↓,
3048- SK,    Shikonin inhibits triple-negative breast cancer-cell metastasis by reversing the epithelial-to-mesenchymal transition via glycogen synthase kinase 3β-regulated suppression of β-catenin signaling
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, 4T1 - in-vitro, Nor, MCF12A - in-vivo, NA, NA
tumCV↓, selectivity↑, EMT↓, TumCMig↓, TumCI↓, E-cadherin↑, N-cadherin↓, Vim↓, Snail↓, β-catenin/ZEB1↓, GSK‐3β↑,
1688- SSE,    Potential Role of Selenium in the Treatment of Cancer and Viral Infections
- Review, Var, NA
IL2↑, INF-γ↑, Th1 response↑, Th2↑, Dose↑, AntiCan∅, Risk↑, chemoP↑, Hif1a↓, VEGF↓, selectivity↑, *GADD45A↑, NRF2↓, *NRF2↑, ChemoSen↑, angioG↓, PrxI↓, ChemoSideEff↓, Synergy↑,
5078- SSE,  Rad,    Results from a Phase 1 Study of Sodium Selenite in Combination with Palliative Radiation Therapy in Patients with Metastatic Cancer
- Trial, Pca, NA
Half-Life↝, OS↑, Pain↓, PSA↓, GSH↓, ROS↑, selectivity↑, TumCG↓, AR↓, Dose↑, ChemoSen↑, RadioS↑,
5074- SSE,    Application of Sodium Selenite in the Prevention and Treatment of Cancers
- Review, Var, NA
Imm↑, angioG↑, DNArepair↑, NK cell↑, ROS↑, AntiCan↑, selectivity↑, ER Stress↑, TumAuto↑, necrosis↑, toxicity↝, Dose↑,
5093- SSE,    Pharmacological mechanisms of the anticancer action of sodium selenite against peritoneal cancer in mice
- in-vivo, Var, NA
AntiCan↑, eff↑, selectivity↑, ROS↑, Dose↝, Trx↓, GSH↓,
5110- SSE,    Autophagy inhibition through PI3K/Akt increases apoptosis by sodium selenite in NB4 cells
- in-vitro, AML, APL NB4
Apoptosis↑, selectivity↑, TumAuto↓, PI3K↓, Akt↓,
5088- SSE,    Superoxide-mediated ferroptosis in human cancer cells induced by sodium selenite
- in-vitro, BC, MCF7 - in-vitro, GBM, U87MG - in-vitro, Pca, PC3 - in-vitro, Cerv, HeLa - in-vitro, GBM, A172
Ferroptosis↑, ROS↑, Iron↑, xCT/SLC7A11↓, GSH↓, GPx4↓, lipid-P↑, TumCP↓, selectivity↑,
5086- SSE,    Sodium Selenite Induces Superoxide-Mediated Mitochondrial Damage and Subsequent Autophagic Cell Death in Malignant Glioma Cells
- in-vitro, GBM, U87MG - in-vitro, GBM, T98G - in-vitro, GBM, A172
TumAuto↑, ROS↑, TumCD↑, tumCV↓, selectivity↑, MMP↓, eff↓, MitoP↑,
4742- SSE,    Antitumor Effects of Selenium
- Review, Var, NA - Review, Arthritis, NA - Review, Sepsis, NA
*antiOx↓, *Inflam↓, Risk↓, TumCI↓, TumMeta↓, radioP↑, chemoP↑, Apoptosis↑, ROS↑, DNAdam↑, Dose↑, selectivity↑, *other↓, *BioAv↑, ROS↑, MMP↓, Casp↑, *Imm↑, *Pain↓, Sepsis↓, MMP2↓, MMP9↓, *Half-Life↓,
6438- T4O,    Terpinen-4-ol inhibits colorectal cancer growth via reactive oxygen species
- in-vitro, CRC, HCT116
mt-ROS↑, TumCP↑, tumCV↑, eff↓, TumVol↓, selectivity↑,
6436- T4O,    Terpinen-4-ol suppresses proliferation and motility of cutaneous squamous cell carcinoma cells by enhancing calpain-2 expression
- in-vitro, Melanoma, A431
TumCP↓, TumCMig↓, TumCI↓, Apoptosis↑, EMT↓, AntiTum↑, cal2↑, cl‑β-catenin/ZEB1↑, cl‑Casp12↑, Bcl-2↓, cycD1/CCND1↓, CDK2↓, BAX↑, TumCCA↑, selectivity↑, N-cadherin↓, E-cadherin↑, Ki-67↓, PCNA↑,
6435- T4O,    Antitumor effect of Melaleuca alternifolia essential oil and its main component terpinen-4-ol in combination with target therapy in melanoma models
- in-vitro, Melanoma, NA
selectivity↑, Apoptosis↑, Synergy↑, ChemoSen↑, BioAv↝,
6432- T4O,    Terpinen-4-ol inhibits colorectal cancer growth via reactive oxygen species
- in-vitro, CRC, HCT116
other↝, Apoptosis↑, mt-ROS↑, eff↓, tumCV↓, TumCP↓, selectivity↑, TumCG↓,
5327- TFdiG,    Theaflavin-3, 3'-digallate induces apoptosis and G2 cell cycle arrest through the Akt/MDM2/p53 pathway in cisplatin-resistant ovarian cancer A2780/CP70 cells
- in-vitro, Ovarian, A2780S
TumCG↓, selectivity↑, TumCCA↑, Apoptosis↑, P53↑, BAX↑, BAD↑, cl‑Casp3↑, p‑Akt↓, MDM2↓, MMP↓, Cyt‑c↑,
5330- TFdiG,  Cisplatin,    Theaflavin-3,3′-Digallate Enhances the Inhibitory Effect of Cisplatin by Regulating the Copper Transporter 1 and Glutathione in Human Ovarian Cancer Cells
- in-vitro, Ovarian, A2780S - in-vitro, Ovarian, OVCAR-3
selectivity↑, ChemoSen↑, DNAdam↑, GSH↓, CTR1↑,
1935- TQ,    Potential anticancer properties and mechanisms of thymoquinone in osteosarcoma and bone metastasis
- Review, OS, NA
Apoptosis↑, TumCCA↑, angioG↓, TumMeta↓, ROS↑, P53↑, Twist↓, E-cadherin↑, N-cadherin↓, NF-kB↓, IL8↓, XIAP↓, Bcl-2↓, STAT3↓, MAPK↓, PI3K↓, Akt↓, ERK↓, MMP2↓, MMP9↓, *ROS↓, HO-1↑, selectivity↑, TumCG↓,
1936- TQ,    Thymoquinone induces apoptosis and increase ROS in ovarian cancer cell line
- in-vitro, Ovarian, CaOV3 - in-vitro, Nor, WRL68
selectivity↑, TumCP↓, MMP↓, Bcl-2↓, BAX↑, ROS↑,
2124- TQ,    Thymoquinone: an emerging natural drug with a wide range of medical applications
- Review, Var, NA
hepatoP↑, Bax:Bcl2↑, cycD1/CCND1↓, P21↑, TRAIL↑, P53↑, TumCCA↑, hepatoP↑, *ALAT↓, *AST↓, *MDA↓, *GSSG↓, *COX2/PTGS2↓, *lipid-P↓, PPARγ↑, p38↑, ROS↑, ChemoSen↑, selectivity↑, selectivity↑, *MDA↓, *SOD↑, *antiAll↑,
2084- TQ,    Thymoquinone, as an anticancer molecule: from basic research to clinical investigation
- Review, Var, NA
*ROS↓, *chemoPv↑, ROS↑, ROS⇅, MUC4↓, selectivity↑, AR↓, cycD1/CCND1↓, Bcl-2↓, Bcl-xL↓, survivin↓, Mcl-1↓, VEGF↓, cl‑PARP↑, ROS↑, HSP70/HSPA5↑, P53↑, miR-34a↑, Rac1↓, TumCCA↑, NOTCH↓, NF-kB↓, IκB↓, p‑p65↓, IAP1↓, IAP2/BIRC3↑, XIAP↓, TNF-α↓, COX2/PTGS2↓, Inflam↓, α-tubulin↓, Twist↓, EMT↓, mTOR↓, PI3K↓, Akt↓, BioAv↓, ChemoSen↑, CompStab↑, PTEN↑, chemoPv↑, RadioS↑, *Half-Life↝, *BioAv↝,
2093- TQ,    Regulation of NF-κB Expression by Thymoquinone; A Role in Regulating Pro-Inflammatory Cytokines and Programmed Cell Death in Hepatic Cancer Cells
- in-vitro, Liver, HepG2 - in-vitro, Nor, NA
TumCD↑, selectivity↑, Casp3↑, DLC1↑, NF-kB↑, LDH↑, *toxicity↓,
2096- TQ,    Effect of total hydroalcholic extract of Nigella sativa and its n-hexane and ethyl acetate fractions on ACHN and GP-293 cell lines
- in-vitro, Nor, GP-293 - in-vitro, Kidney, ACHN
selectivity↑, eff↝,
2097- TQ,    Crude extract of Nigella sativa inhibits proliferation and induces apoptosis in human cervical carcinoma HeLa cells
- in-vitro, Cerv, HeLa
Cyt‑c↑, Bax:Bcl2↑, Casp3↑, Casp9↑, Casp8↑, cl‑PARP↑, cMyc↓, hTERT/TERT↓, cycD1/CCND1↓, CDK4↓, P53↑, P21↑, TumCP↓, Apoptosis↓, selectivity↑,

Showing Research Papers: 601 to 650 of 677
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 677

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↓, 1,   NA↑, 3,   NA⇅, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 3,   antiOx↑, 16,   antiOx⇅, 1,   Catalase↓, 8,   Catalase↑, 3,   ENOX2↓, 2,   Fenton↑, 8,   frataxin↑, 1,   GCLC↑, 1,   GPx↓, 2,   GPx↑, 2,   GPx4↓, 6,   GSH?, 1,   GSH↓, 45,   GSH↑, 5,   i-GSH∅, 1,   GSH/GSSG↓, 8,   GSSG↑, 3,   GSTs↝, 1,   H2O2↓, 2,   H2O2↑, 14,   mt-H2O2↑, 1,   HO-1↓, 3,   HO-1↑, 10,   HO-2↓, 1,   Iron↓, 4,   Iron↑, 4,   i-Iron↓, 1,   Keap1↓, 2,   Keap1↑, 2,   Keap1↝, 1,   lipid-P↓, 2,   lipid-P↑, 20,   lipidDe↓, 1,   MDA↓, 3,   MDA↑, 7,   i-MDA↑, 1,   NADH↓, 3,   NADH↑, 1,   mt-NADH↓, 1,   NADHdeh?, 1,   NOX↓, 2,   NOX↑, 1,   NOX4↑, 1,   NQO1↓, 2,   NQO1↑, 2,   NRF2↓, 11,   NRF2↑, 13,   NRF2∅, 1,   p‑NRF2↑, 1,   Prx↓, 1,   Prx3↑, 1,   Prx4↓, 1,   Prx4↑, 1,   PrxI↓, 1,   RNS↑, 3,   ROS?, 4,   ROS↓, 22,   ROS↑, 311,   ROS⇅, 10,   ROS↝, 3,   ROS∅, 4,   i-ROS?, 1,   i-ROS↓, 1,   i-ROS↑, 4,   mt-ROS↑, 22,   RPM↑, 1,   SOD↓, 5,   SOD↑, 5,   SOD2↓, 3,   SOD2↑, 1,   Thiols↓, 3,   Trx↓, 4,   Trx↑, 1,   TrxR↓, 9,   TrxR1↓, 2,   mt-TrxR1↓, 1,   xCT/SLC7A11↓, 4,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1,   IronCh↑, 1,   IronCh∅, 1,   STEAP3↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↑, 1,   p‑CDC2↓, 1,   CDC25↓, 5,   CDC25↑, 1,   compI↓, 7,   compII↓, 1,   compIII↓, 2,   compIII↑, 1,   compIV↓, 1,   compV↓, 1,   EGF↓, 2,   ETC↓, 10,   ETC↝, 1,   HSP60/HSPD1↑, 1,   Insulin↓, 3,   mitResp↓, 8,   mitResp↑, 1,   mtDam↑, 38,   OCR↓, 9,   OCR↑, 5,   OXPHOS↓, 9,   OXPHOS↑, 5,   mt-OXPHOS↓, 2,   mt-OXPHOS↑, 2,   PDH↑, 1,   p‑PDH↓, 2,   p‑PDH↑, 1,   PGC-1α↑, 2,   PINK1↑, 1,   SDH↓, 1,   SIRT3↓, 1,   SIRT3↑, 4,   mt-TrxR2↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,   5LO↓, 1,   p‑ACC↑, 1,   ACLY↓, 1,   ALAT↓, 2,   AminoA↓, 1,   AMP↑, 1,   AMPK↑, 12,   p‑AMPK↑, 3,   ANXA7↑, 2,   ATP↓, 27,   ATP∅, 1,   ATP:AMP↓, 1,   cAMP↓, 1,   ECAR↓, 7,   ECAR↝, 1,   ECAR∅, 1,   FABP4↓, 1,   FAO↓, 1,   FAO↑, 1,   FASN↓, 1,   GAPDH↓, 2,   glucose↝, 1,   GlucoseCon↓, 16,   GlucoseCon∅, 1,   Glycolysis↓, 34,   Glycolysis∅, 1,   GSK‐3β↓, 4,   GSK‐3β↑, 5,   p‑GSK‐3β↓, 1,   H2S↑, 1,   Histones↝, 1,   HK2?, 1,   HK2↓, 11,   HK2∅, 1,   HMG-CoA↓, 5,   IDO1↓, 2,   KeyT↑, 1,   lactateProd↓, 21,   lactateProd↑, 1,   lactateProd∅, 1,   LDHA↓, 5,   LDHA∅, 1,   LDL↓, 2,   lipidLev↓, 1,   lipoGen↓, 2,   MCT4↓, 1,   NAD↓, 2,   NADPH↓, 4,   NADPH↑, 2,   OAA↑, 1,   PDK1 / PDPK1?, 2,   PDK1 / PDPK1↓, 8,   p‑PDK1 / PDPK1↓, 1,   PDKs↓, 6,   PDKs↑, 1,   PFK↓, 2,   PFK1↓, 2,   PFKP↓, 1,   PKM1↑, 1,   PKM2↓, 9,   polyA↓, 1,   PPP↑, 1,   Pyruv↓, 1,   SCD1↓, 4,   SIRT1↓, 4,   SIRT1↑, 2,   SREBP1/SREBF1↓, 1,   TCA?, 1,   TCA↓, 1,   TS↓, 2,   Warburg↓, 9,  

Cell Death(tgid=5) ⓘ

AIF↑, 17,   APAF1↑, 1,   Apoptosis?, 1,   Apoptosis↓, 11,   Apoptosis↑, 256,   Apoptosis∅, 1,   mt-Apoptosis↑, 4,   aSmase↑, 1,   BAD↓, 2,   BAD↑, 9,   Bak↑, 6,   BAX?, 1,   BAX↓, 2,   BAX↑, 87,   BAX⇅, 2,   Bax:Bcl2↓, 1,   Bax:Bcl2↑, 25,   Bcl-2?, 1,   Bcl-2↓, 95,   Bcl-2↑, 1,   Bcl-xL↓, 20,   BID↑, 4,   p‑BID↓, 1,   cl‑BID↑, 1,   BIM↑, 2,   BNIP3?, 1,   Casp↓, 2,   Casp↑, 37,   Casp↝, 1,   Casp1↑, 2,   Casp12↑, 1,   cl‑Casp12↑, 1,   Casp3?, 1,   Casp3↓, 4,   Casp3↑, 120,   cl‑Casp3↑, 25,   proCasp3↓, 1,   pro‑Casp3↓, 1,   pro‑Casp3↑, 1,   CASP4↑, 1,   Casp6↓, 1,   Casp6↑, 2,   Casp7↑, 21,   cl‑Casp7↑, 2,   Casp8↓, 2,   Casp8↑, 38,   cl‑Casp8↑, 1,   Casp9↓, 1,   Casp9↑, 76,   cl‑Casp9↑, 5,   pro‑Casp9↑, 1,   cFLIP↓, 2,   Cupro↑, 2,   Cyt‑c↓, 2,   Cyt‑c↑, 84,   Cyt‑c↝, 1,   Diablo↑, 4,   DR5↑, 13,   Endon↑, 2,   FADD↑, 2,   Fap1↓, 1,   Fas↓, 1,   Fas↑, 14,   FasL↑, 8,   Ferroptosis↑, 13,   GSDMC↑, 1,   GSDMD↑, 1,   IAP1↓, 2,   IAP1↑, 1,   IAP2/BIRC3↓, 2,   IAP2/BIRC3↑, 1,   ICAD↑, 1,   iNOS↓, 4,   Mcl-1↓, 10,   Mcl-1↑, 1,   p‑Mcl-1↓, 1,   MDM2↓, 6,   MDM2↑, 2,   MLKL↑, 1,   p‑MLKL↓, 1,   MOMP↓, 2,   MOMP↑, 3,   Necroptosis↑, 3,   necrosis↑, 5,   NOXA↑, 2,   p38↓, 2,   p38↑, 8,   p‑p38↓, 1,   p‑p38↑, 6,   Paraptosis↑, 5,   PUMA↑, 5,   Pyro↑, 5,   RIP1↓, 1,   RIP3↑, 1,   p‑RIP3↑, 1,   SK↓, 1,   survivin↓, 26,   TNFR 1↑, 1,   TRAIL↑, 5,   TumCD↓, 2,   TumCD↑, 50,   TUNEL↑, 1,   XIAP↓, 13,   YAP/TEAD↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt?, 1,   Akt↓, 75,   Akt↑, 4,   p‑Akt↓, 28,   p‑Akt↑, 1,   AKT1↓, 3,   AMPKα↑, 1,   CaMKII ↓, 1,   Cavin3↓, 1,   CIP2A↓, 1,   cSrc↓, 1,   EF-1α↓, 1,   EGFR↓, 14,   p‑EGFR↓, 1,   ERK↓, 25,   ERK↑, 4,   p‑ERK↓, 10,   p‑ERK↑, 3,   HER2/EBBR2↓, 2,   Hippo↑, 1,   IGF-1R↓, 1,   p‑IGF-1R↓, 1,   IKKα↓, 3,   IKKα↑, 1,   IκB↓, 1,   IκB↑, 1,   JAK↓, 3,   JAK1↓, 2,   JAK1↑, 1,   JAK2↓, 7,   JNK↓, 6,   JNK↑, 16,   p‑JNK↑, 7,   MAPK↓, 17,   MAPK↑, 8,   p‑MAPK↑, 2,   MARK4↓, 2,   MEK↓, 4,   MKP1↓, 1,   MKP2↓, 1,   mTOR↓, 36,   mTOR↑, 1,   mTOR⇅, 1,   p‑mTOR↓, 7,   mTORC2↑, 1,   p70S6↓, 1,   p‑P70S6K↓, 1,   P90RSK↓, 1,   PI3K↓, 47,   PI3K↑, 2,   p‑PI3K↓, 7,   PI3K/Akt↓, 1,   PIAS-3↑, 1,   PKA↓, 2,   PKCδ↓, 4,   PKCδ↑, 2,   PTEN↑, 12,   Raf↓, 3,   c-Raf↓, 1,   RAS↓, 4,   p‑S6K↓, 2,   SHP1↑, 1,   Sp1/3/4↓, 8,   Src↓, 2,   p‑Src↓, 1,   STAT↓, 3,   STAT3↓, 34,   STAT3↑, 1,   p‑STAT3↓, 6,   p‑STAT3↑, 2,   mt-STAT3↓, 1,   STAT4↓, 1,   STAT6↓, 2,   p‑STK11/LKB1↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF3↓, 1,   ATF3↑, 1,   ATF4↑, 6,   ATF4↝, 1,   BRD4↓, 1,   ChrMod↑, 2,   cJun↑, 3,   cMyc↓, 17,   cMyc↑, 1,   DNMT1↓, 6,   DNMT1↑, 1,   DNMTs↓, 5,   EZH2↓, 4,   FOXO↑, 2,   FOXO3↓, 1,   FOXO3↝, 1,   p‑FOXO3↓, 1,   FOXO4↑, 2,   GATA3↓, 1,   H3↑, 2,   ac‑H3↑, 4,   ac‑H3↝, 1,   H4↑, 1,   ac‑H4↓, 1,   ac‑H4↑, 4,   HATs↓, 2,   HATs↑, 2,   HDAC↓, 22,   HDAC1↓, 4,   HDAC2↓, 2,   HDAC3↓, 3,   HDAC4↓, 1,   HDAC8↓, 1,   miR-124-3p↓, 1,   miR-148a↑, 1,   miR-203↑, 1,   miR-21↓, 2,   miR-34a↑, 1,   miR-375↑, 1,   Myc↓, 1,   n-MYC↓, 1,   OCT4↓, 3,   other?, 1,   other↓, 2,   other↑, 15,   other⇅, 1,   other↝, 22,   other∅, 1,   PhotoS↑, 1,   PRMT6↓, 1,   SETBP1↓, 1,   SOX2↓, 2,   SOX4↓, 1,   SOX4↑, 1,   SUV39H↓, 1,   SUZ12↓, 1,   tumCV?, 1,   tumCV↓, 111,   tumCV↑, 4,   UTF1↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 3,   CHOP/DDIT3↓, 2,   CHOP/DDIT3↑, 21,   cl‑CHOP/DDIT3↑, 1,   eIF2α↑, 2,   p‑eIF2α↓, 1,   p‑eIF2α↑, 2,   ER Stress↓, 1,   ER Stress↑, 40,   ERStress↑, 1,   GRP78/BiP?, 1,   GRP78/BiP↓, 2,   GRP78/BiP↑, 9,   HSP27↑, 1,   HSP70/HSPA5↓, 2,   HSP70/HSPA5↑, 3,   HSP90↓, 7,   IRE1↑, 3,   PERK↓, 1,   PERK↑, 7,   p‑PERK↑, 1,   Proteasome?, 1,   Proteasome↓, 1,   UPR↑, 8,   XBP-1↓, 1,   XBP-1↑, 2,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 6,   ATG7↑, 3,   Beclin-1/ATG6↓, 3,   Beclin-1/ATG6↑, 6,   CTSK↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 2,   LC3B↑, 2,   LC3B-II↓, 1,   LC3B-II↑, 2,   LC3I↑, 1,   LC3II↑, 9,   LC3s↓, 1,   lysoMP↑, 1,   MitoP↑, 1,   p62↓, 5,   p62↑, 6,   p‑p62↑, 1,   PARK2↑, 1,   SESN2↑, 1,   TumAuto?, 1,   TumAuto↓, 1,   TumAuto↑, 30,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 1,   BRCA1↓, 1,   p‑BRCA1↑, 1,   BRCA2↓, 1,   DNA-PK↑, 2,   DNAdam↓, 1,   DNAdam↑, 85,   DNArepair↓, 2,   DNArepair↑, 1,   FEN1↓, 1,   G9a↓, 1,   hTERT/TERT↓, 5,   Ku70/XRCC6↓, 1,   MGMT↓, 1,   p16↑, 1,   P53↓, 2,   P53↑, 70,   P53↝, 3,   p‑P53↑, 3,   p53 Wildtype↓, 1,   p53 Wildtype↑, 1,   PARP↓, 9,   PARP↑, 13,   PARP↝, 1,   p‑PARP↑, 2,   cl‑PARP↓, 1,   cl‑PARP↑, 58,   PARP1↑, 2,   cl‑PARP1↑, 2,   PCNA↓, 15,   PCNA↑, 1,   SIRT6↓, 1,   SIRT6↑, 1,   Telomerase↓, 8,   TOP1↓, 4,   TOP1↝, 1,   TOP2↓, 2,   TOP2↑, 2,   TP53↑, 1,   UHRF1↓, 1,   XRCC1↓, 1,   γH2AX↑, 9,  

Cell Cycle & Senescence(tgid=11) ⓘ

ANAPC2↑, 1,   AURKB↑, 1,   BRD4↓, 1,   CC(CDKs/cyclins)↓, 1,   CC(CDKs/cyclins)↑, 1,   CDK1↓, 7,   CDK1↑, 1,   CDK2↓, 29,   CDK2↑, 1,   CDK4↓, 33,   CDK4↑, 1,   p‑CDK4↓, 1,   CDK6↓, 9,   CDK6↑, 3,   CDK8↓, 1,   CDKN1C/p57↑, 1,   Cyc↓, 2,   cycA1/CCNA1↓, 5,   CycB/CCNB1↓, 15,   CycB/CCNB1↑, 3,   cycD1/CCND1↓, 48,   cycD1/CCND1↑, 1,   p‑cycD1/CCND1↓, 1,   CycD3↓, 1,   cycE/CCNE↓, 16,   cycE1↓, 2,   cycF↑, 1,   E2Fs↓, 2,   FBXO5/EMI1↓, 1,   GADD34↑, 1,   GADD45A↑, 2,   Ki-67↓, 14,   P21?, 1,   P21↓, 5,   P21↑, 48,   p27/CDKN1B↓, 3,   p27/CDKN1B↑, 21,   PLK1↓, 1,   pRB↓, 1,   pRB↑, 1,   p‑pRB↓, 2,   p‑RB1↓, 4,   TubPol↓, 1,   TumCCA?, 3,   TumCCA↓, 4,   TumCCA↑, 178,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

p‑4E-BP1↓, 1,   ALDH↓, 3,   ALDH1A1↓, 2,   ALDH1A3↓, 1,   BMI1↓, 1,   CD133↓, 3,   CD24↓, 4,   cFos↓, 1,   cFos↑, 1,   cMYB↓, 1,   CSCs↓, 36,   CSCs↑, 1,   Diff↓, 3,   Diff↑, 7,   EP4/PTGER4↓, 1,   HH↓, 2,   HH↝, 1,   HMGCR↓, 1,   HMGCR↑, 1,   IGF-1↓, 3,   IGFBP3↑, 1,   Ki-67↓, 14,   mTORC1↓, 1,   p‑mTORC1↓, 1,   Nanog↓, 2,   Nestin↓, 2,   NOTCH↓, 6,   NOTCH↝, 1,   NOTCH1↓, 5,   NOTCH3↓, 2,   p300↓, 1,   SCF↓, 1,   Shh↓, 2,   STAT1↓, 1,   TOPflash↓, 1,   TumCG?, 1,   TumCG↓, 121,   TumCG↑, 4,   TumCG∅, 2,   TumCP?, 1,   TumCP↓, 140,   TumCP↑, 2,   Wnt↓, 21,   Wnt↝, 1,   Wnt/(β-catenin)↓, 4,  

Migration(tgid=13) ⓘ

AntiAg↑, 1,   AP-1↓, 7,   ATPase↓, 1,   CA↓, 1,   Ca+2↓, 7,   Ca+2↑, 34,   Ca+2↝, 4,   i-Ca+2?, 1,   i-Ca+2↑, 2,   cal2↑, 1,   Cav1↑, 1,   CCN2/CTGF↓, 1,   Cdc42↓, 1,   Cdc42↑, 1,   i-Chl↑, 1,   Cofilin↓, 1,   p‑Cofilin↑, 1,   CTNNB1↓, 1,   DLC1↑, 1,   E-cadherin↓, 1,   E-cadherin↑, 20,   EMT↓, 37,   EpCAM↓, 1,   F-actin↓, 2,   FAK↓, 5,   FAK↑, 1,   FAK↝, 1,   p‑FAK↓, 2,   fascin↓, 1,   Fibronectin↓, 2,   FOSB↑, 1,   ITGB1↓, 2,   ITGB3↓, 1,   ITGB6↓, 1,   KRAS↓, 1,   MALAT1↓, 2,   MMP1↓, 1,   MMP2↓, 45,   MMP2↑, 1,   MMP3↓, 1,   MMP7↓, 2,   MMP9↓, 45,   MMPs↓, 11,   MUC4↓, 1,   N-cadherin?, 1,   N-cadherin↓, 10,   N-cadherin↑, 1,   PAK1↓, 2,   PDGF↓, 4,   Rac1↓, 2,   RECK↑, 2,   Rho↓, 3,   ROCK1↓, 1,   Slug↓, 4,   Smad1↑, 1,   p‑SMAD2↓, 1,   SMAD3↓, 1,   p‑SMAD3↓, 1,   Snail↓, 9,   TET1↑, 1,   TG2/TGase↓, 1,   TGF-β↓, 6,   TIMP1↓, 1,   TIMP1↑, 4,   TIMP2↑, 6,   TIMP3↑, 1,   TSC1↑, 1,   TumCA↑, 1,   TumCI↓, 58,   TumCMig↓, 67,   TumMeta↓, 43,   TumMeta↑, 1,   Twist↓, 12,   uPA↓, 7,   Vim↓, 10,   Zeb1↓, 7,   ZEB2↓, 1,   α-tubulin↓, 2,   β-catenin/ZEB1↓, 23,   β-catenin/ZEB1↑, 1,   cl‑β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 55,   angioG↑, 3,   CD31/PECAM-1↓, 1,   CD31/PECAM-1↑, 1,   EGR1↑, 1,   Endoglin↑, 2,   HIF-1↓, 5,   Hif1a↓, 31,   Hif1a↑, 2,   HIF2a↓, 1,   Hypoxia↓, 1,   LOX1↓, 1,   NO↓, 2,   NO↑, 7,   PHDs↓, 1,   VCAM-1↓, 1,   VEGF↓, 43,   VEGFR1↓, 1,   VEGFR2/KDR/Flk1↓, 9,  

Barriers & Transport(tgid=15) ⓘ

AQPs↓, 1,   BBB↑, 2,   CellMemb↑, 2,   CLDN1↓, 1,   CTR1↑, 1,   EPR↑, 9,   GLUT1↓, 8,   GLUT1↑, 1,   GLUT2↓, 2,   GLUT4↓, 1,   MMP?, 2,   MMP↓, 152,   MMP↝, 1,   MPT↓, 1,   MPT↑, 9,   NHE1↓, 2,   sonoP↑, 1,   SVCT-2↓, 1,   TRPC1↑, 1,   TRPM7↓, 1,   TRPV1↓, 1,   TRPV1↑, 4,   TRPV2↑, 1,   VGCC↑, 1,   VGSC↑, 2,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

B2M↓, 1,   CCR7↓, 1,   CD4+↑, 1,   CD44↓, 10,   CD47↓, 1,   CD8+↑, 4,   cDC2↓, 1,   p‑cDC2↓, 1,   COX1↓, 2,   COX2/PTGS2↓, 32,   COX2/PTGS2↑, 4,   CXCc↓, 1,   CXCR4↓, 3,   DCells↑, 2,   DR4↑, 3,   DR6↑, 1,   FOXP3↓, 1,   HMGB1↓, 2,   ICAM-1↓, 3,   Igs↑, 1,   IL1↓, 2,   IL1↑, 1,   IL10↓, 1,   IL10↑, 1,   IL1β↓, 7,   IL1β↑, 3,   IL2↑, 1,   IL6↓, 15,   IL8↓, 4,   IL8↑, 1,   Imm↑, 9,   Imm↝, 1,   INF-γ↑, 1,   Inflam↓, 28,   LIF↑, 1,   M2 MC↓, 1,   MCP1/CCL2↓, 2,   MCT1↓, 1,   NF-kB↓, 71,   NF-kB↑, 9,   p‑NF-kB↑, 2,   NK cell↑, 8,   NLRP3↓, 1,   NLRP3↑, 3,   p50↓, 1,   p65↓, 3,   p‑p65↓, 1,   PD-L1↓, 3,   PGE2↓, 8,   PSA↓, 5,   RAGE↓, 1,   SOCS-3↓, 1,   SOCS-3↑, 1,   T-Cell↑, 2,   Th1 response↑, 1,   Th2↑, 1,   TLR4↓, 3,   TNF-α↓, 17,   TNF-α↑, 6,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 2,  

Cellular Microenvironment(tgid=17) ⓘ

pH↑, 1,   pH↝, 2,   e-pH↑, 1,   i-pH↓, 1,   i-pH↑, 2,  

Protein Aggregation(tgid=19) ⓘ

PSEN1/PS1↓, 1,   PSEN2/PS-2↓, 1,   p‑tau↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

6IL↑, 1,   AhR↑, 1,   AR↓, 9,   CYP24A1↓, 1,   ER-α36↓, 2,   ER(estro)↓, 1,   ERα/ESR1↓, 1,   EstroRS/ERS↓, 1,   PPARα↓, 1,   cl‑PPARα↓, 1,   PPARγ↓, 1,   PPARγ↑, 6,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 1,   BioAv↓, 31,   BioAv↑, 33,   BioAv↝, 5,   BioEnh↑, 1,   chemoR↓, 2,   ChemoSen↓, 1,   ChemoSen↑, 153,   ChemoSen∅, 3,   CompStab↓, 1,   CompStab↑, 2,   CompStab↝, 1,   CYP1A1↓, 2,   CYP1A1↑, 1,   CYP1A2↑, 1,   CYP2A3/CYP2A6↓, 1,   CYP2E1↑, 1,   CYP3A4↓, 1,   DDS↑, 1,   Dose?, 8,   Dose↓, 10,   Dose↑, 15,   Dose⇅, 1,   Dose↝, 81,   Dose∅, 18,   eff?, 1,   eff↓, 87,   eff↑, 140,   eff↝, 22,   GSTP1/GSTπ↓, 1,   GSTZ1↓, 1,   Half-Life?, 1,   Half-Life↓, 6,   Half-Life↑, 4,   Half-Life↝, 11,   Half-Life∅, 1,   MDR1↓, 2,   MRP1/ABCC1↓, 2,   MRP1/ABCC1↝, 1,   P-gp/ABCB1↓, 10,   P-gp/ABCB1∅, 1,   P450↓, 1,   P450↑, 1,   P450↝, 1,   RadioS↓, 1,   RadioS↑, 64,   selectivity?, 9,   selectivity↓, 10,   selectivity↑, 676,   selectivity↝, 2,   selectivity∅, 4,   Synergy↑, 91,  

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 1,   ALAT↓, 2,   ALP↓, 1,   AR↓, 9,   AST↓, 1,   B2M↓, 1,   BG↓, 4,   BloodF↑, 1,   BMD↑, 1,   BRCA1↓, 1,   p‑BRCA1↑, 1,   CRP↓, 1,   E6↓, 1,   E7↓, 1,   EGFR↓, 14,   p‑EGFR↓, 1,   ERα/ESR1↓, 1,   EstroRS/ERS↓, 1,   EZH2↓, 4,   Ferritin↓, 1,   HER2/EBBR2↓, 2,   hTERT/TERT↓, 5,   IL6↓, 15,   KeyT↑, 1,   KRAS↓, 1,   LDH?, 1,   LDH↓, 5,   LDH↑, 6,   Maspin↑, 1,   Myc↓, 1,   NOS2↓, 2,   NOS2↑, 1,   PD-L1↓, 3,   PSA↓, 5,   RAGE↓, 1,   SUZ12↓, 1,   TP53↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 55,   AntiCan∅, 1,   antiCG↓, 1,   AntiDiabetic↑, 1,   antiNeop↑, 1,   antiNeop∅, 1,   AntiTum↓, 1,   AntiTum↑, 24,   Appetite↑, 1,   BowelM↑, 1,   breath↑, 1,   cachexia↓, 1,   cardioP↑, 6,   CardioT↓, 1,   chemoP↑, 29,   chemoPv↑, 21,   ChemoSideEff↓, 3,   fatigue↓, 1,   hepatoP↑, 10,   hepatoP∅, 1,   neuroP↑, 8,   NP/CIPN↓, 1,   OS↑, 30,   OS⇅, 1,   OS∅, 1,   Pain↓, 4,   PDE4↓, 1,   PFS↑, 1,   QoL↑, 9,   radioP↑, 16,   Remission↑, 2,   RenoP↑, 4,   Risk↓, 13,   Risk↑, 1,   Sleep↑, 1,   Strength↑, 2,   toxicity↓, 28,   toxicity↑, 2,   toxicity⇅, 1,   toxicity↝, 13,   toxicity∅, 5,   TumVol↓, 36,   TumW↓, 17,   Weight↑, 4,   Wound Healing↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 1,   AntiP↑, 4,   Bacteria↓, 5,   GutMicro↑, 3,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,   Ingr↝, 5,  
Total Targets: 956

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx?, 1,   antiOx↓, 2,   antiOx↑, 68,   mt-antiOx↑, 1,   ARE↑, 1,   Catalase↑, 21,   Copper↓, 1,   Fenton↓, 2,   GPx↑, 18,   GPx1↑, 1,   GPx4↑, 1,   GSH↓, 1,   GSH↑, 18,   GSH/GSSG↑, 1,   GSR↑, 2,   GSSG↓, 1,   GSSG∅, 1,   GSTs↑, 7,   H2O2↓, 1,   H2O2↑, 1,   HDL↓, 1,   HDL↑, 3,   HO-1↑, 13,   hyperG↓, 1,   Iron↓, 2,   Iron↑, 1,   Iron∅, 1,   lipid-P↓, 15,   MDA↓, 12,   MPO↓, 2,   NOX↓, 1,   NOX4↓, 1,   Nrf1↑, 1,   NRF2↑, 21,   Prx↑, 1,   Prx4∅, 1,   RNS↓, 3,   ROS?, 2,   ROS↓, 64,   ROS↑, 4,   ROS∅, 18,   SAM-e↑, 1,   selenoP↑, 2,   SOD?, 1,   SOD↓, 1,   SOD↑, 23,   SOD1↑, 3,   SOD2↑, 2,   TAC↑, 1,   TBARS↓, 2,   VitC↑, 2,   VitE↓, 1,   VitE↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compII↑, 1,   compIII↑, 1,   EGF↓, 1,   mitResp↑, 1,   OCR↑, 1,   OXPHOS↑, 1,   PGC-1α↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 2,   ACLY∅, 1,   ALAT↓, 4,   AMPK↑, 1,   ATP↑, 4,   ATP↝, 1,   ECAR↓, 1,   GlucoseCon↑, 2,   Glycolysis↓, 2,   Glycolysis↑, 1,   GSK‐3β↓, 2,   HK2↓, 1,   HMG-CoA↓, 1,   lactateProd↓, 1,   LDL↓, 4,   lipidLev↓, 1,   NAD↑, 1,   NAD↝, 1,   NADPH↓, 1,   NADPH↑, 1,   NADPH∅, 1,   PFK↓, 1,   SIRT1↑, 3,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 4,   BAX↓, 1,   Bax:Bcl2↓, 1,   Bcl-2↑, 2,   Bcl-xL↑, 1,   Casp1↓, 1,   Casp12↓, 1,   Casp3↓, 3,   Casp3∅, 1,   cl‑Casp8↑, 1,   Casp9↓, 1,   Cyt‑c↓, 2,   Cyt‑c∅, 1,   Ferroptosis↓, 1,   GranB/GZMB↓, 1,   IAP1↓, 1,   iNOS↓, 5,   p38↓, 1,   survivin↓, 1,   TumCD↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 1,   Akt↑, 2,   p‑Akt↓, 1,   ERK↓, 1,   ERK↑, 1,   p‑ERK↑, 1,   HGF/c-Met↑, 1,   JAK2↑, 1,   JNK↓, 1,   JNK↑, 1,   p‑JNK↓, 1,   MAPK↓, 1,   mTOR↓, 4,   PI3K↑, 2,   PKCδ?, 1,   PTEN↑, 1,   STAT↓, 1,   STAT3↓, 1,   STAT3↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF4↓, 1,   other↓, 2,   other↑, 2,   other↝, 7,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,   CHOP/DDIT3↑, 1,   p‑eIF2α↓, 1,   cl‑eIF2α↑, 1,   ER Stress↓, 1,   GRP78/BiP↓, 1,   GRP78/BiP↑, 1,   HSP27↓, 1,   HSP70/HSPA5↓, 1,   p‑PERK↑, 1,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

LC3‑Ⅱ/LC3‑Ⅰ↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 10,   DNAdam↑, 1,   P53↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

cellSen↑, 1,   GADD45A↑, 1,   P21↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMPs↑, 1,   Diff↑, 1,   EP2↓, 1,   FGF↑, 1,   neuroG↑, 1,   TumCP↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 2,   Ca+2↓, 4,   Ca+2↑, 1,   Ca+2↝, 2,   Ca+2∅, 1,   i-Ca+2↓, 1,   MMP13↓, 1,   MMP9↓, 1,   MMPs↑, 1,   PDGF↑, 1,   serineP↓, 1,   TGF-β↑, 2,   TIMP1↓, 1,   TumCI↓, 1,   TumCMig↓, 1,   α-tubulin↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   angioG↑, 1,   HIF-1↓, 1,   Hif1a↓, 1,   Hif1a↑, 2,   NO↓, 4,   VCAM-1↓, 1,   VEGF↓, 1,   VEGF↑, 2,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 1,   BBB↑, 6,   GastroP↑, 1,   GLUT1↓, 1,   IBI↑, 1,   MMP↑, 2,   MMP∅, 2,   SVCT-2↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD25+↑, 1,   CD4+↑, 2,   COX2/PTGS2↓, 10,   FOXP3↑, 1,   HMGB1↓, 1,   IFN-γ↓, 3,   IL1↑, 1,   IL10↓, 1,   IL10↑, 2,   IL17↓, 2,   IL1β↓, 9,   IL23↓, 1,   IL4↓, 1,   IL4↑, 1,   IL6↓, 8,   IL8↓, 1,   Imm↑, 7,   Inflam↓, 61,   LPS↓, 1,   M2 MC↑, 1,   MCP1/CCL2↓, 3,   NF-kB↓, 14,   NLRP3↓, 2,   NLRP3↑, 1,   PGE2↓, 2,   PSA∅, 1,   TLR4↓, 1,   TNF-α↓, 11,   TNF-α↑, 1,   Treg lymp↝, 1,   VitD↑, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   AChE↓, 3,   AChE↑, 1,   BDNF↑, 5,   MAOA↓, 2,   β-Endo↑, 1,  

Protein Aggregation(tgid=19) ⓘ

APP↓, 1,   Aβ↓, 7,   BACE/β-secretase↓, 1,   tau↓, 2,   XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

GR↑, 3,   PPARγ↑, 1,   testos↑, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 19,   BioAv↑, 21,   BioAv↝, 5,   BioEnh↑, 1,   CompStab↑, 2,   CompStab↝, 1,   Dose?, 1,   Dose↓, 1,   Dose↑, 2,   Dose↝, 13,   eff↑, 9,   eff↝, 1,   GSTA1↓, 1,   GSTA1↑, 1,   Half-Life↓, 3,   Half-Life↑, 1,   Half-Life↝, 3,   Half-Life∅, 2,   P450↓, 1,   selectivity↑, 13,   selectivity⇅, 1,   Synergy↑, 6,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 4,   ALP↓, 2,   AST↓, 4,   BG↓, 1,   BMD↑, 2,   BP↓, 4,   Calcium↑, 1,   creat↓, 2,   CRP↓, 3,   HbA1c↓, 1,   HOMA↓, 1,   hs-CRP↓, 2,   IL6↓, 8,   LDH↓, 1,   Mag↑, 1,   PSA∅, 1,   SpO2↑, 1,   TC↓, 1,   TG/TAG↓, 2,   Urea↓, 1,   VitD↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 5,   antiAll↑, 7,   AntiArt↑, 2,   AntiCan↓, 1,   AntiCan↑, 9,   AntiDiabetic↑, 10,   antiPs↑, 1,   AntiTum↓, 1,   AntiTum↑, 1,   cardioP↑, 16,   CardioT↓, 1,   chemoP↑, 12,   chemoPv↑, 3,   ChemoSideEff↓, 1,   cognitive↑, 5,   diuretic↑, 1,   hepatoP↑, 11,   memory↑, 8,   neuroP↑, 28,   Obesity↓, 4,   OS↑, 3,   Pain↓, 3,   radioP↑, 5,   RenoP↑, 3,   Risk↓, 2,   Stress↓, 1,   Stroke↓, 2,   toxicity?, 2,   toxicity↓, 53,   toxicity↝, 11,   toxicity∅, 19,   Weight↑, 1,   Wound Healing↑, 2,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 5,   AntiViral↑, 3,   Bacteria↓, 15,   GutMicro↑, 5,   Inf↓, 1,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↑, 1,   Ingr↝, 2,  
Total Targets: 313

Scientific Paper Hit Count for: selectivity, selectivity
35 Silver-NanoParticles
30 Magnetic Fields
20 Radiotherapy/Radiation
17 Piperlongumine
14 Selenium NanoParticles
13 Thymoquinone
12 Chemotherapy
12 Betulinic acid
12 Dandelion Root
10 Vitamin C (Ascorbic Acid)
10 doxorubicin
10 chitosan
10 Sulforaphane (mainly Broccoli)
10 Dichloroacetate
10 salinomycin
10 Fisetin
10 Phenethyl isothiocyanate
10 Shikonin
9 Capsaicin
9 Propolis -bee glue
9 Cisplatin
9 Magnetic Field Rotating
8 Carvacrol
8 Copper and Cu NanoParticles
8 Hydrogen Gas
8 Honokiol
8 Ivermectin
8 Magnolol
8 Quercetin
8 Selenite (Sodium)
7 Artemisinin
7 Berberine
7 Curcumin
7 Kaempferol
6 3-bromopyruvate
6 Fenbendazole
6 Apigenin (mainly Parsley)
6 Ashwagandha(Withaferin A)
6 Melatonin
6 Baicalein
6 Chrysin
6 Lemongrass Extract/Citral
6 EGCG (Epigallocatechin Gallate)
6 Gallic acid
6 HydroxyTyrosol
6 Linalool
5 Rosmarinic acid
5 Metformin
5 Boron
5 Selenium
5 Ellagic acid
5 Hibiscus sabdariffa
5 Indole-3-carbinol
5 Licochalcone A
4 Alpha-Lipoic-Acid
4 Phenylbutyrate
4 Gold NanoParticles
4 α-Bisabolol / Chamomile oil
4 NTP, Non-Thermal Plasma,Cold Atmospheric Plasma
4 chaetocin
4 diet FMD Fasting Mimicking Diet
4 diet Methionine-Restricted Diet
4 Eurycomanone
4 Eugenol
4 Graviola
4 phytic acid, Inositol hexakisphosphate
4 Lactoferrin/Talactoferrin
4 Luteolin
4 Lutein
4 Lycopene
4 mebendazole
4 Methyl Jasmonate
4 Morin
4 Parthenolide
4 α-Santalol/Sandalwood oil
4 Terpinen-4-ol / Tea Tree Oil
4 VitK3,menadione
3 1,8-Cineole
3 chemodynamic therapy
3 Allicin (mainly Garlic)
3 Astaxanthin
3 Atorvastatin
3 Caffeic acid
3 Centella asiatica / Gotu kola → asiaticoside
3 Citric Acid
3 Coenzyme Q10
3 Cynaropicrin
3 Date Fruit Extract
3 Shilajit/Fulvic Acid
3 γ-linolenic acid (Borage Oil)
3 Helleborus niger extracts – Christmas Rose
3 Isobavachalcone
3 Isoliquiritigenin
3 isoorientin
3 isoquercitrin
3 Recombinant Methioninase
3 Nimbolide
3 Urolithin
2 Dipyridamole
2 Berbamine
2 Bifidobacterium
2 immunotherapy
2 Caffeic Acid Phenethyl Ester (CAPE)
2 Crocetin
2 Cynara scolymus/Globe Artichoke/Artichoke Extract
2 Hydroxycinnamic-acid
2 Dihydrocaffeic Acid
2 Docosahexaenoic Acid
2 Oxygen, Hyperbaric
2 D-limonene
2 Disulfiram
2 Electrical Pulses
2 Evodiamine
2 Fucoidan
2 Gambogic Acid
2 Ginkgo biloba
2 Geldanamycin
2 Gossypol/AT-101
2 Hyperthermia
2 Hyperoside
2 Inositol
2 iodine
2 Juglone
2 Licorice
2 Methylene blue
2 methylseleninic acid
2 Methylglyoxal
2 Mushroom Lion’s Mane, Hericium erinaceus
2 Marjoram (Origanum majorana)
2 SonoDynamic Therapy UltraSound
2 Plumbagin
2 Sulfasalazine
2 polyethylene glycol
2 Silymarin (Milk Thistle) silibinin
2 Aflavin-3,3′-digallate
2 Vitexin
2 Zerumbone
1 Auranofin
1 Anzaroot, Astragalus fasciculifolius Bioss
1 Glucose
1 Ajoene (compound of Garlic)
1 Acetyl-l-carnitine
1 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
1 Sorafenib (brand name Nexavar)
1 5-Aminolevulinic acid
1 Baicalin
1 Bufalin/Huachansu
1 probiotics
1 Brucea javanica
1 Brutieridin–Melitidin Mixture
1 Boswellia (frankincense)
1 Bullatacin
1 Butyrate
1 Carnosic acid
1 urea
1 Thymol-Thymus vulgaris
1 Cat’s Claw
1 Cannabidiol
1 Chocolate
1 Calorie Restriction Mimetics
1 Carvone
1 Polyphenols
1 Cucurbitacin
1 Cysteamine
1 Dichloroacetophenone(2,2-)
1 Deguelin
1 Diclofenac
1 diet Ketogenic
1 Docetaxel
1 Dimethyl Sulfoxide
1 Mistletoe/Viscum album Extracts
1 Echinacea
1 Ginkgo biloba-EGb 761
1 5-fluorouracil
1 PXD, phenoxodiol
1 Emodin
1 Fennel Oil/Foeniculum vulgare
1 ferumoxytol
1 Formononetin
1 Flaxseed/Linseed
1 Flaxseed Oil
1 olaparib/LYNPARZA
1 Garcinol
1 Ginkgolic acids
1 Genistein (soy isoflavone)
1 Geraniol
1 Ginkgetin
1 Ginseng
1 Grapeseed extract
1 High-Ozonide Oil
1 Paclitaxel/Taxol
1 Gemcitabine (Gemzar)
1 isoflavones
1 Isovitexin
1 Lactobacillus
1 lambertianic acid
1 low dose naltrexone
1 Photodynamic Therapy
1 Matrine
1 Mung Bean Sprouts
1 Lemon Balm/Melissa officinalis
1 Moringa oleifera
1 Mushroom Chaga, Inonotus obliquus
1 Bicarbonate(Sodium)
1 Oleuropein
1 Propyl gallate
1 temozolomide
1 borneol
1 Psoralidin
1 Pterostilbene
1 Resveratrol
1 irinotecan
1 triptolide
1 Ursolic acid
1 Vitamin B1/Thiamine
1 Vitamin K2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1110  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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