| Source: HalifaxProj(inhibit) |
| Type: |
| NF-kB signaling Nuclear factor kappa B (NF-κB) is a transcription factor that plays a crucial role in regulating immune response, inflammation, cell proliferation, and survival. NF-κB is often found to be constitutively active in many types of cancer cells. This persistent activation can promote tumorigenesis by enhancing cell survival, proliferation, and metastasis. |
| 7592- | I3C, | Indole-3-carbinol as a chemopreventive and anti-cancer agent |
| - | Review, | Var, | NA |
| 7804- | IBC, | Isobavachalcone: A comprehensive review of its plant sources, pharmacokinetics, toxicity, pharmacological activities and related molecular mechanisms |
| - | Review, | Nor, | NA |
| 7635- | Ins, | The Role of Inositols in Endocrine and Neuroendocrine Tumors |
| - | Review, | Thyroid, | NA |
| 7631- | Ins, | IP6, | Broad Spectrum Anticancer Activity of Myo-Inositol and Inositol Hexakisphosphate |
| - | Review, | Var, | NA |
| 7654- | IP, | Dietary Supplementation of Inulin Contributes to the Prevention of Estrogen Receptor-Negative Mammary Cancer by Alteration of Gut Microbial Communities and Epigenetic Regulations |
| - | in-vivo, | BC, | NA |
| - | in-vivo, | BC, | NA |
| 7713- | IP6, | PacT, | Inositol hexaphosphate and paclitaxel: symbiotic treatment of oral cavity squamous cell carcinoma |
| - | in-vitro, | Oral, | Ca9-22 | - | in-vitro, | Oral, | HN5 |
| 7724- | IP6, | Inositol hexakisphosphate blocks tumor cell growth by activating apoptotic machinery as well as by inhibiting the Akt/NFkappaB-mediated cell survival pathway |
| - | in-vitro, | Cerv, | HeLa |
| 7645- | IP6, | Ins, | Anticancer Properties of Inositol Hexaphosphate and Inositol: An Overview |
| 7690- | IP6, | Ins, | Inositol Hexaphosphate (IP6) and Colon Cancer: From Concepts and First Experiments to Clinical Application |
| - | Review, | Colon, | NA |
| 7692- | IP6, | Inositol hexaphosphate inhibits constitutive activation of NF- kappa B in androgen-independent human prostate carcinoma DU145 cells |
| - | in-vitro, | Pca, | DU145 |
| 7699- | IP6, | IP6: From Seeds to Science—A Natural Compound’s Path to Clinical Promise |
| - | Review, | Var, | NA |
| 7763- | ISL, | Harnessing Liquiritigenin: A Flavonoid-Based Approach for the Prevention and Treatment of Cancer |
| 7746- | ISL, | Isoliquiritigenin Inhibits the Growth of Colorectal Cancer Cells through the ESR2/PI3K/AKT Signalling Pathway |
| - | vitro+vivo, | CRC, | SW480 | - | vitro+vivo, | CRC, | HCT116 |
| 7750- | ISL, | Isoliquiritigenin in Breast Cancer: A Systematic Review of Its Preventive and Anti-metastatic Mechanisms |
| - | Review, | BC, | NA |
| 7754- | ISL, | Isoliquiritigenin Confers Neuroprotection and Alleviates Amyloid-β42-Induced Neuroinflammation in Microglia by Regulating the Nrf2/NF-κB Signaling |
| - | in-vitro, | AD, | BV2 |
| 7758- | ISL, | Targeting the JAK/STAT pathway with isoliquiritigenin in ovarian cancer: molecular mechanisms and therapeutic implications |
| - | Review, | Ovarian, | NA |
| 7760- | ISL, | Pharmacological Potentials and Delivery Strategies of Isoliquiritigenin: Challenges and Advances in Enhancing Bioavailability |
| - | Review, | Nor, | NA |
| 7761- | ISL, | Targeting digestive system cancers with isoliquiritigenin: a comprehensive review of antitumor mechanisms |
| - | Review, | Var, | NA |
| 7781- | ISL, | Perspectives on the Role of Isoliquiritigenin in Cancer |
| - | Review, | Var, | NA |
| 7735- | isoFl, | Soy Isoflavones in Integrative Oncology: Increased Efficacy and Decreased Toxicity of Cancer Therapy |
| - | Review, | Var, | NA |
| 7866- | isoO, | Orientin and Cancer Suppression: Molecular Mechanisms and Synergistic Effects |
| - | Review, | Var, | NA |
| 7864- | isoO, | Isoorientin Inhibits Amyloid β25-35-Induced Neuronal Inflammation in BV2 Cells by Blocking the NF-κB Signaling Pathway |
| - | in-vitro, | AD, | BV2 |
| 7862- | isoO, | Isoorientin attenuates lipopolysaccharide-induced pro-inflammatory responses through down-regulation of ROS-related MAPK/NF-κB signaling pathway in BV-2 microglia |
| - | in-vitro, | Nor, | BV2 |
| 7861- | isoO, | Isoorientin Inhibits Inflammation in Macrophages and Endotoxemia Mice by Regulating Glycogen Synthase Kinase 3 β |
| - | vitro+vivo, | Nor, | RAW264.7 |
| 7852- | isoO, | Neuroprotection of isoorientin against microglia activation induced by lipopolysaccharide via regulating GSK3β, NF-κb and Nrf2/HO-1 pathways |
| - | in-vitro, | AD, | NA |
| 7853- | isoO, | Natural flavonoid isoorientin and its anticancer mechanisms: a systematic review |
| - | Review, | Var, | NA |
| 7855- | isoO, | Isoorientin induces apoptosis and autophagy simultaneously by reactive oxygen species (ROS)-related p53, PI3K/Akt, JNK, and p38 signaling pathways in HepG2 cancer cells |
| - | in-vitro, | Liver, | HepG2 | - | in-vitro, | Nor, | HL7702 |
| 7856- | isoO, | Isoorientin induces the apoptosis and cell cycle arrest of A549 human lung cancer cells via the ROS‑regulated MAPK, STAT3 and NF‑κB signaling pathways |
| - | in-vitro, | Lung, | A549 |
| 7868- | isoO, | Isoorientin Suppresses Invasion of Breast and Colon Cancer Cells by Inhibition of CXC Chemokine Receptor 4 Expression |
| 7886- | isoO, | Vascular barrier protective effects of orientin and isoorientin in LPS-induced inflammation in vitro and in vivo |
| - | vitro+vivo, | Nor, | NA |
| 7884- | isoO, | Orientin Ameliorates LPS-Induced Inflammatory Responses through the Inhibitory of the NF-κB Pathway and NLRP3 Inflammasome |
| - | in-vitro, | Nor, | RAW264.7 |
| 7875- | isoO, | Isoorientin Inhibits Amyloid β25–35-Induced Neuronal Inflammation in BV2 Cells by Blocking the NF-κB Signaling Pathway |
| - | in-vitro, | Nor, | BV2 |
| 7822- | isoO, | Isoorientin Affects Markers of Alzheimer's Disease via Effects on the Oral and Gut Microbiota in APP/PS1 Mice |
| - | in-vivo, | AD, | NA |
| 7812- | ISQ, | Isoquercitrin promotes ferroptosis and oxidative stress in nasopharyngeal carcinoma via the AMPK/NF-κB pathway |
| - | vitro+vivo, | NPC, | CNE1 | - | in-vitro, | NPC, | HNE1 |
| 7890- | IVT, | Isovitexin protects against cisplatin-induced kidney injury in mice through inhibiting inflammatory and oxidative responses |
| - | in-vivo, | Nor, | NA |
| 7900- | IVT, | Isovitexin: A Promising Active Compound Found in Nature's Bounty |
| - | in-vivo, | Nor, | NA |
| 7911- | IVT, | Isovitexin Depresses Osteoarthritis Progression via the Nrf2/NF-κB Pathway: An in vitro Study |
| - | in-vitro, | Arthritis, | NA |
| 7888- | IVT, | Isovitexin Exerts Anti-Inflammatory and Anti-Oxidant Activities on Lipopolysaccharide-Induced Acute Lung Injury by Inhibiting MAPK and NF-κB and Activating HO-1/Nrf2 Pathways |
| - | vitro+vivo, | Nor, | NA |
| 5119- | JG, | Juglone Suppresses Inflammation and Oxidative Stress in Colitis Mice |
| - | in-vivo, | Nor, | NA |
| 4293- | LT, | Regulatory Role of NF-κB on HDAC2 and Tau Hyperphosphorylation in Diabetic Encephalopathy and the Therapeutic Potential of Luteolin |
| - | in-vivo, | Diabetic, | NA |
| 4292- | LT, | Luteolin for neurodegenerative diseases: a review |
| - | Review, | AD, | NA | - | Review, | Park, | NA | - | Review, | MS, | NA | - | Review, | Stroke, | NA |
| 2921- | LT, | Luteolin as a potential hepatoprotective drug: Molecular mechanisms and treatment strategies |
| - | Review, | Nor, | NA |
| 2906- | LT, | Luteolin, a flavonoid with potentials for cancer prevention and therapy |
| - | Review, | Var, | NA |
| 2911- | LT, | Luteolin targets MKK4 to attenuate particulate matter-induced MMP-1 and inflammation in human keratinocytes |
| - | in-vitro, | Nor, | HaCaT |
| 2912- | LT, | Luteolin: a flavonoid with a multifaceted anticancer potential |
| - | Review, | Var, | NA |
| 2914- | LT, | Therapeutic Potential of Luteolin on Cancer |
| - | Review, | Var, | NA |
| 2922- | LT, | Combination of transcriptomic and proteomic approaches helps unravel the mechanisms of luteolin in inducing liver cancer cell death via targeting AKT1 and SRC |
| - | in-vitro, | Liver, | HUH7 |
| 2919- | LT, | Luteolin as a potential therapeutic candidate for lung cancer: Emerging preclinical evidence |
| - | Review, | Var, | NA |
| 2916- | LT, | Antioxidative and Anticancer Potential of Luteolin: A Comprehensive Approach Against Wide Range of Human Malignancies |
| - | Review, | Var, | NA | - | Review, | AD, | NA | - | Review, | Park, | NA |
Query results interpretion may depend on "conditions" listed in the research papers. Such Conditions may include : -low or high Dose -format for product, such as nano of lipid formations -different cell line effects -synergies with other products -if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:% IllCat:% CanType:% Cells:% prod#:% Target#:214 State#:% Dir#:%
wNotes=0 sortOrder:rid,rpid