TumCCA Cancer Research Results

TumCCA, Tumor cell cycle arrest: Click to Expand ⟱
Source:
Type:
Tumor cell cycle arrest refers to the process by which cancer cells stop progressing through the cell cycle, which is the series of phases that a cell goes through to divide and replicate. This arrest can occur at various checkpoints in the cell cycle, including the G1, S, G2, and M phases. S, G1, G2, and M are the four phases of mitosis.
Scientific Papers found: Click to Expand⟱
292- HCA,    Hydroxycitric Acid Inhibits Chronic Myelogenous Leukemia Growth through Activation of AMPK and mTOR Pathway
- in-vitro, AML, K562
ACLY↓, TumCG↓, AMPK↑, mTOR↑, UPR↑, eIF2α↑, ATF4↑, TumCCA↑, DNAdam↑,
1638- HCAs,    Anticancer potential of hydroxycinnamic acids: mechanisms, bioavailability, and therapeutic applications
- Review, Nor, NA
*BioAv↓, Inflam↓, COX2/PTGS2↓, TumCCA↑, ChemoSen↑, RadioS↑, selectivity↑, ROS↑, DNAdam↑, antiOx↑, SOD↑, Catalase↑, GPx↑, GSH↑, NRF2↑, NF-kB↓, Cyc↓, CDK1↑, P21↑, p27/CDKN1B↑, P53↑, VEGF↓, MAPK↓,
1643- HCAs,    Mechanisms involved in the anticancer effects of sinapic acid
- Review, Var, NA
*BioAv↓, *toxicity↓, Dose∅, ROS⇅, ROS↑, Igs↑, TumCCA↑, TumAuto↑, eff↑, angioG↓, TumCI↓, TumMeta↓, EMT↓, Vim↓, MMP9↓, MMP2↓, Snail↓, E-cadherin↑, p‑Akt↓, GSK‐3β↓, TumCP↓, ChemoSen↑,
1649- HCAs,    Anticancer Properties of Hydroxycinnamic Acids -A Review
- Review, Var, NA
*antiOx↑, MMP2↓, MMP9↓, VEGF↓, TGF-β↓, Bax:Bcl2↑, TumCCA↑, COX2/PTGS2↓, NF-kB↓,
7359- HibSad,    Novel Insight into the Cellular and Molecular Signalling Pathways on Cancer Preventing Effects of Hibiscus sabdariffa: A Review - PubMed
- Review, Var, NA
AntiCan↑, TumCP↓, Apoptosis↑, TumCCA↑, P53↑, P21↑, p27/CDKN1B↑, BAD↑, BAX↑, Casp3↑, Casp7↑, Casp8↑, Casp9↑, *AntiBio↑, *Inflam↓, *antiOx↑, *BP↓, *AntiDiabetic↑, HDAC1↓, HDAC3↓, tumCV↓, LDL↓, DNAdam↑, MMP↓, *Catalase↑, *SOD↑, *GPx↑, *GSH↑, *antiOx↑, *ROS↓, TumCMig↓, TumCI↓, selectivity↑, RAS↓, Akt↓, NF-kB↓, MMP2↓, PI3K↓, Bcl-2↓, Bcl-xL↓, PCNA↓, cycA1/CCNA1↓, cycD1/CCND1↓, cycE/CCNE↓,
7365- HibSad,    Insight into the molecular evidence supporting the remarkable chemotherapeutic potential of Hibiscus sabdariffa L
- Review, Var, NA
chemoPv↑, selectivity↑, TumCCA↑, Apoptosis↑, TumAuto↑, TumMeta↓, ATG5↑, Beclin-1/ATG6↑, LC3II↑, MMP2↓, MMP9↓, CD31/PECAM-1↓, VEGF↓, uPA↓, TIMP2↑, NF-kB↓, p38↑, P53↑, Casp3↑, Casp8↑, Casp9↑, Bcl-2↓, BAX↑, Cyt‑c↑, TNF-α↑, Fas↑, FasL↑, JNK↑, cJun↑, angioG↓, VEGFR2/KDR/Flk1↓, PCNA↓, CCN2/CTGF↓, RAGE↓,
7350- HibSad,    Hibiscus polyphenol-rich extract induces apoptosis in human gastric carcinoma cells via p53 phosphorylation and p38 MAPK/FasL cascade pathway
- in-vitro, GC, AGS
TumCD↑, DNAdam↑, P53↑, Bcl-2↓, Mcl-1↓, Cyt‑c↑, FasL↑, Fas↑, p38↑, BAX↑, Dose↝, TumCCA↑,
7468- HNK,    Honokiol and Its Emerging Role in Breast Cancer Therapy
- Review, BC, NA
*ROS↓, *Inflam↓, CSCs↓, ChemoSen↑, BioAv↑, ROS↑, MMP↓, mtDam↑, TumCCA↑, cycD1/CCND1↓, CDK4↓, Casp3↑, Casp9↑, Bcl-2↓, Bcl-xL↓, BAX↑, p‑STAT3↓, AMPK↑, miR-34a↑, EMT↓, HH↓, Shh↓, Gli1↓, PTCH1↓, NF-kB↓, TNF-α↓, IL6↓, Glycolysis↓, GlucoseCon↓, BioAv↓, BioAv↓, Half-Life↝,
7463- HNK,    Honokiol Inhibits Colorectal Cancer Cell Growth: Involvement of Hsp27 as a Molecular Target
- in-vitro, CRC, NA
TumCG↓, TumCCA↑, Cyt‑c↑, Apoptosis↑, cl‑PARP↑, Bcl-2↓, HSP27↓,
2875- HNK,    Inhibition of class I histone deacetylases in non-small cell lung cancer by honokiol leads to suppression of cancer cell growth and induction of cell death in vitro and in vivo
- in-vitro, Lung, A549 - in-vitro, Lung, H1299 - in-vitro, Lung, H460 - in-vitro, SCC, H226
HDAC↓, tumCV↓, TumCCA↑, cycD1/CCND1↓, ac‑H3↑, ac‑H4↑, selectivity↑, CDK2↓, CDK4↓,
2879- HNK,    Honokiol Inhibits Lung Tumorigenesis through Inhibition of Mitochondrial Function
- in-vitro, Lung, H226 - in-vivo, NA, NA
tumCV↓, selectivity↑, TumCP↓, TumCCA↑, Apoptosis↑, mt-ROS↑, Casp3↑, Casp7↑, OCR↓, Cyt‑c↑, ATP↓, mitResp↓, AMP↑, AMPK↑,
2881- HNK,    Honokiol Suppressed Pancreatic Cancer Progression via miR-101/Mcl-1 Axis
- in-vitro, PC, PANC1
tumCV↓, Casp3↑, Apoptosis↑, TumCCA↑, TumCI↓, Mcl-1↓, EMT↓,
2864- HNK,    Honokiol: A Review of Its Anticancer Potential and Mechanisms
- Review, Var, NA
TumCCA↑, CDK2↓, EMT↓, MMPs↓, AMPK↑, TumCI↓, TumCMig↓, TumMeta↓, VEGFR2/KDR/Flk1↓, *antiOx↑, *Inflam↓, *BBB↑, *neuroP↑, *ROS↓, Dose↝, selectivity↑, Casp3↑, Casp9↑, NOTCH1↓, cycD1/CCND1↓, cMyc↓, P21?, DR5↑, cl‑PARP↑, P53↑, Mcl-1↑, p65↓, NF-kB↓, ROS↑, JNK↑, NRF2↑, cJun↑, EF-1α↓, MAPK↓, PI3K↓, mTORC1↓, CSCs↓, OCT4↓, Nanog↓, SOX4↓, STAT3↓, CDK4↓, p‑RB1↓, PGE2↓, COX2/PTGS2↓, β-catenin/ZEB1↑, IKKα↓, HDAC↓, HATs↑, H3↑, H4↑, LC3II↑, c-Raf↓, SIRT3↑, Hif1a↓, ER Stress↑, GRP78/BiP↑, cl‑CHOP/DDIT3↑, MMP↓, PCNA↓, Zeb1↓, NOTCH3↓, CD133↓, Nestin↓, ATG5↑, ATG7↑, survivin↓, ChemoSen↑, SOX2↓, OS↑, P-gp/ABCB1↓, Half-Life↓, Half-Life↝, Synergy↑, BioAv↓,
2892- HNK,    Honokiol Induces Apoptosis, G1 Arrest, and Autophagy in KRAS Mutant Lung Cancer Cells
- in-vitro, Lung, A549 - in-vitro, Lung, H460 - in-vitro, Lung, H385 - in-vitro, Nor, BEAS-2B
TumCCA↑, Apoptosis↑, SIRT3↑, Hif1a↓, selectivity↑, p‑mTOR↓, p70S6↓,
2898- HNK,    Honokiol Suppression of Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Gastric Cancer Cell Biological Activity and Its Mechanism
- in-vitro, GC, AGS - in-vitro, GC, NCI-N87 - in-vitro, BC, MGC803 - in-vitro, GC, SGC-7901
TumCP↓, Apoptosis↑, TumCI↓, TumCMig↓, HER2/EBBR2↓, TumCCA↑, PI3K↓, Akt↓, MMP9↓, P21↑,
1004- HNK,  RAPA,    Honokiol downregulates PD-L1 expression and enhances antitumor effects of mTOR inhibitors in renal cancer cells
- in-vitro, RCC, NA
Apoptosis↑, TumCCA↑, ROS↑, PD-L1↓, IFN-γ↓,
2073- HNK,    Honokiol induces apoptosis and autophagy via the ROS/ERK1/2 signaling pathway in human osteosarcoma cells in vitro and in vivo
- in-vitro, OS, U2OS - in-vivo, NA, NA
TumCD↑, TumAuto↑, Apoptosis↑, TumCCA↑, GRP78/BiP↑, ROS↑, eff↓, p‑ERK↑, selectivity↑, Ca+2↑, MMP↓, Casp3↑, Casp9↑, cl‑PARP↑, Bcl-2↓, Bcl-xL↓, survivin↓, LC3B-II↑, ATG5↑, TumVol↓, TumW↓, ER Stress↑,
2080- HNK,    Honokiol Induces Ferroptosis by Upregulating HMOX1 in Acute Myeloid Leukemia Cells
- in-vitro, AML, THP1 - in-vitro, AML, U937 - in-vitro, AML, SK-HEP-1
tumCV↓, TumCCA↑, Ferroptosis↑, lipid-P↑, HO-1↑, GPx4∅,
4523- HNK,  MAG,  BA,    Honokiol-Magnolol-Baicalin Possesses Synergistic Anticancer Potential and Enhances the Efficacy of Anti-PD-1 Immunotherapy in Colorectal Cancer by Triggering GSDME-Dependent Pyroptosis
- in-vitro, CRC, HCT116 - in-vitro, CRC, LoVo - in-vivo, CRC, HCT116
AntiCan↑, eff↑, TumCP↓, TumCCA↓, cycD1/CCND1↓, Pyro↑, Apoptosis↑, cl‑GSDME↑, Bcl-2↓, Cyt‑c↑, Casp9↑, TumCG↓,
7372- HOO,    Ozone-modified properties of pumpkin seed oil as anti-H. pylori, anticancer, anti-diabetic and anti-obesity agent
- in-vitro, Pca, PC3
Apoptosis↑, AntiDiabetic↑, Obesity↑, TumCCA↑, other↝,
7625- HPT,    Hyperthermia adds to trabectedin effectiveness and thermal enhancement is associated with BRCA2 degradation and impairment of DNA homologous recombination repair
- in-vitro, sarcoma, NA
TumCD↑, TumCCA↑, Apoptosis↑, BRCA2↓, ChemoSen↑,
5051- HPT,  doxoR,    Hyperthermia Enhances Doxorubicin Therapeutic Efficacy against A375 and MNT-1 Melanoma Cells
- in-vitro, Melanoma, A375
tumCV↓, TumCCA↑, ROS↑, Synergy↑,
7542- HT,    Hydroxytyrosol Induces Apoptosis and Cell Cycle Arrest and Suppresses Multiple Oncogenic Signaling Pathways in Prostate Cancer Cells
- in-vitro, Pca, LNCaP - in-vitro, Pca, C4-2B - in-vitro, Nor, RWPE-1
TumCP↓, selectivity↑, TumCCA↑, cycD1/CCND1↓, CDK2↓, CDK4↓, Apoptosis↑, Casp↑, cl‑PARP↑, Bax:Bcl2↑, tumCV↓, Akt↓, STAT3↓, NF-kB↓, AR↓, ROS↑, mtDam↑, BioAv↓, toxicity↓, eff↑,
7540- HT,    Discovery of hydroxytyrosol as thioredoxin reductase 1 inhibitor to induce apoptosis and G1/S cell cycle arrest in human colorectal cancer cells via ROS generation
- in-vitro, CRC, HCT8 - in-vitro, CRC, HCT116
TrxR1↑, ROS↑, TumCP↓, Apoptosis↑, TumCCA↑, Dose↝, eff↓,
7528- HT,    Involvement of the PI3K/AKT Intracellular Signaling Pathway in the AntiCancer Activity of Hydroxytyrosol, a Polyphenol from Olea europaea, in Hematological Cells and Implication of HSP60 Levels in Its Anti-Inflammatory Activity
- in-vitro, AML, Jurkat - in-vitro, AML, HL-60 - in-vitro, NA, 1-
*antiOx↑, *Inflam↓, *AntiBio↑, *cardioP↑, AntiCan↑, TumCCA↑, PI3K↓, MAPK↑, ROS↑, Apoptosis↑, Casp9↑, Bcl-2↓, p‑P53↓,
7539- HT,    Polyphenols Extracts from Oil Production Waste Products (OPWPs) Reduce Cell Viability and Exert Anti-Inflammatory Activity via PPARγ Induction in Colorectal Cancer Cells
- in-vitro, CRC, HCT116 - in-vitro, CRC, LoVo
tumCV↓, Apoptosis↑, TumCCA↑, p‑NF-kB↑, TNF-α↑, IL8↓, PPARγ↑, Inflam↓, Dose↝,
4639- HT,    Hydroxytyrosol Induces Apoptosis, Cell Cycle Arrest and Suppresses Multiple Oncogenic Signaling Pathways in Prostate Cancer Cells
- in-vitro, Pca, LNCaP - in-vitro, Pca, C4-2B
TumCP↓, selectivity↑, TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, P21↑, p27/CDKN1B↑, Apoptosis↑, Casp↑, cl‑PARP↑, Bax:Bcl2↑, p‑Akt↓, p‑STAT3↓, NF-kB↓, AR↓, ROS↑, *BioAv↓, *toxicity∅,
4642- HT,    Hydroxytyrosol, a natural molecule from olive oil, suppresses the growth of human hepatocellular carcinoma cells via inactivating AKT and nuclear factor-kappa B pathways
- in-vitro, HCC, HepG2 - NA, NA, Hep3B - NA, NA, SK-HEP-1
TumCP↓, TumCCA↑, Apoptosis↑, Akt↓, NF-kB↓, TumCG↓, angioG↓,
4633- HT,    Unlocking the effective alliance of β-lapachone and hydroxytyrosol against triple-negative breast cancer cells
- in-vitro, BC, NA
AntiCan↑, CSCs↓, antiOx↑, NQO1↑, TumCCA↑, ER Stress↑, Apoptosis↑, UPR↑,
7570- HYP,    Hyperoside suppresses BMP-7-dependent PI3K/AKT pathway in human hepatocellular carcinoma cells
- in-vitro, Liver, HepG2
TumCCA↑, TumCP↓, BMP7/OP1↓, p‑Akt↓, PI3K↓,
7565- HYP,    Potential Implications of Hyperoside on Oxidative Stress-Induced Human Diseases: A Comprehensive Review
- Review, AD, NA
*Inflam↓, *antiOx↑, *neuroP↑, *lipid-P↓, *ROS↓, *IL1β↓, *IL6↓, *IL8↓, *TNF-α↓, *MDA↓, *BAX↓, *Casp3↓, *Catalase↑, *SOD↑, *GSH↑, *BDNF↑, *TrkB↑, *NGF↑, *BDNF↑, *NF-kB↓, *AChE↓, *H2S↑, Casp3↑, Apoptosis↑, NF-kB↓, AMPK↑, HO-1↑, MAPK↑, cl‑Casp3↑, cl‑Casp9↑, BAX↑, SOD?, Catalase↓, NRF2↓, NQO1↓, HO-1↓, Bcl-2↓, TumCCA↑, FOXO1↑, TumAuto↑, Akt↓, mTOR↓, P70S6K↓, BMP7/OP1↓, *cardioP↑, *hepatoP↑, *antiCG↑, *AntiThr↑, *Diar↓, *AntiFungal↑, *CYP2D6↓, *PDGFR-BB↓, *PDGFRB↓, *toxicity↓, *Half-Life↑,
7547- HYP,    Hyperoside suppresses NSCLC progression by inducing ATG13-mediated autophagy and apoptosis
- vitro+vivo, NSCLC, NA
TumCMig↓, TumCP↓, TumCG↓, Apoptosis↑, TumCCA↑, TumAuto↑, ATG13↑,
7560- HYP,    Hyperoside: A Review of Its Structure, Synthesis, Pharmacology, Pharmacokinetics and Toxicity
- Review, Nor, NA - Review, AD, NA
*RenoP↓, Casp3↑, Casp8↑, MDA↑, GSH↓, SOD↓, Catalase↓, VEGF↓, Bcl-2↓, TumCG↓, p‑Akt↓, PI3K↓, TumCCA↑, TumCP↓, BMP7/OP1↓, *ZO-1↑, *BBB↝, *p‑Akt↑, *GSK‐3β↑, *SOD↑, *Catalase↑, *GSH↑, *SIRT1↑, *NF-kB↓, *IL1β↓, *IL6↓, *IL8↓, *TNF-α↓, *ROS↓, *MDA↓, *BAX↓, *Casp3↓, *Bcl-2↑, *BDNF↑, *TrkB↑, *NGF↑, *Apoptosis↓, *cardioP↑, *AST↓, *hepatoP↑, *AST↓, *ALAT↓, *MDA↓, *BACH1↓, *neuroP↑, *Stroke↓, *ICAM-1↓, *VCAM-1↓, *TLR4↓, *COX2/PTGS2↓, *RenoP↑, *NLRP3↓, *Casp1↓, *ASC↓, *BioAv↓, *BioAv↑, *toxicity↓,
7604- I3C,    Multifunctional aspects of the action of indole-3-carbinol as an antitumor agent
- in-vitro, Var, NA
2/16-OHE1↑, CYP1B1↓, 4-OHE1↓, Apoptosis↑, cycD1/CCND1↓, TumCCA↑, AntiTum↑,
7605- I3C,    Indole-3-carbinol and prostate cancer
- Review, Pca, NA
Risk↓, TumCCA↑, Apoptosis↑, Akt↓, NF-kB↓, ChemoSen↑,
7608- I3C,    Akt inactivation is a key event in indole-3-carbinol-induced apoptosis in PC-3 cells
- in-vitro, Pca, PC3
AntiTum↑, TumCG↓, TumCCA↑, Apoptosis↑, Akt↓, EGF↓, PI3K↓, Bcl-xL↓, BAD↓,
7586- I3C,    Bax translocation to mitochondria is an important event in inducing apoptotic cell death by indole-3-carbinol (I3C) treatment of breast cancer cells
- in-vitro, BC, NA
TumCG↓, Apoptosis↑, BAX↑, Bcl-2↓, MMP↓, Cyt‑c↑, TumCCA↑,
7588- I3C,    Indole-3-carbinol suppresses NF-κB activity and stimulates the p53 pathway in pre-B acute lymphoblastic leukemia cells
- in-vitro, AML, NA
TumCG↓, TumCCA↑, Apoptosis↑, P53↑, P21↑, BAX↑, PUMA↑, NOXA↑, APAF1↑, NF-kB↓, IAP1↓, Bcl-xL↓, Bcl-2↓, XIAP↓, Myc↓, ChemoSen↑, Casp9↑, cl‑PARP↑, eff↑,
7592- I3C,    Indole-3-carbinol as a chemopreventive and anti-cancer agent
- Review, Var, NA
JNK↑, STAT3↓, TumCCA↑, P21↑, p27/CDKN1B↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, CDK6↓, AhR↑, ER-α36↓, ChemoSen↑, ER Stress↑, UPR↑, BRCA1↑, BRCA2↑, TumCMig↓, TumCI↓, VEGF↓, IL8↓, MMP2↓, MMP9↓, RadioS↑, Akt↓, NF-kB↓, DR4↑, DR5↑,
7593- I3C,    Indole-3-carbinol (I3C) induced cell growth inhibition, G1 cell cycle arrest and apoptosis in prostate cancer cells
- Review, Pca, NA
Risk↓, TumCG↓, TumCCA↑, P21↑, p27/CDKN1B↑, CDK6↓, cl‑RB1↓, cl‑PARP↑, BAX↑, Bcl-2↓,
7771- IBC,    Isobavachalcone induces concurrent apoptosis and pyroptosis in anaplastic thyroid cancer cells by modulating the caspase-mediated cleavage of PARP and GSDME
- vitro+vivo, Thyroid, CAL-62
TumCG↓, TumCCA↑, Apoptosis↑, Pyro↑, Casp↑, cl‑PARP↑, cl‑GSDME↑, TrxR1↓, ROS↑, ER Stress↑, Dose↝,
7631- Ins,  IP6,    Broad Spectrum Anticancer Activity of Myo-Inositol and Inositol Hexakisphosphate
- Review, Var, NA
other↑, p‑pRB↓, TumCCA↑, PI3K↓, Akt↓, ERK↓, NF-kB↓, COX2/PTGS2↓, PGE2↓, PSEN1/PS1↓, EMT↓, Wnt↓, β-catenin/ZEB1↓, NOTCH1↓, N-cadherin↓, Snail↓, E-cadherin↑, fascin↓, Cofilin↓, MMPs↓, ROCK1↓, Dose↝, other↝, selectivity↑, *ROS↓, *lipid-P↓, ROS↑, NK cell↑, Imm↑, TNF-α↓, ChemoSen↑, Dose↑, toxicity↓, QoL↑, chemoP↑, OS↑, Dose↝, Insulin↓, glucose↝, lipoGen↓, Synergy↑,
7678- iod,    Signaling pathways involved in the antiproliferative effect of molecular iodine in normal and tumoral breast cells: evidence that 6-iodolactone mediates apoptotic effects
- in-vitro, Nor, MCF12A - in-vitro, BC, MCF7
TumCCA↑, selectivity↑, 6IL↑, eff↑,
7655- IP,  SFN,    Combined Phytochemical Sulforaphane and Dietary Fiber Inulin Contribute to the Prevention of ER-Negative Breast Cancer via PI3K/AKT/MTOR Pathway and Modulating Gut Microbial Composition
- in-vivo, BC, NA
Dose↝, TumCG↓, TumW↓, GutMicro↑, HDAC↓, DNMTs↓, Akt↓, PI3K↓, mTOR↓, NF-kB↓, TumCCA↑, cl‑Casp3↑, cl‑Casp7↑, CDK2↓, CDK4↓, Risk↓, Dose↝,
7728- IP6,    G0/G1 arrest and S phase inhibition of human cancer cell lines by inositol hexaphosphate (IP6)
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231 - in-vitro, CRC, HT-29
AntiCan↑, TumCCA↑, Ki-67↓, PCNA↓,
7718- IP6,    Inositol hexaphosphate inhibits growth, and induces G1 arrest and apoptotic death of prostate carcinoma DU145 cells: modulation of CDKI-CDK-cyclin and pRb-related protein-E2F complexes
- in-vitro, Pca, DU145
chemoPv↑, TumCG↓, TumCCA↑, P21↓, p27/CDKN1B↑, CDK2↓, CDK4↓, CDK6↓, cycE/CCNE↓, cycD1/CCND1↓, pRB↑, Apoptosis↑, cl‑PARP↑, Casp3↑,
7719- IP6,    Effect of inositol hexaphosphate (IP(6)) on human normal and leukaemic haematopoietic cells
- in-vitro, CML, NA
TumCD↑, TumCCA↑, selectivity↑, TumCP↓,
7722- IP6,    Cancer inhibition by inositol hexaphosphate (IP6) and inositol: from laboratory to clinic
- Review, Var, NA
Synergy↑, TumCP↓, Diff↑, TumCCA↑, Imm↑, antiOx↑, BioAv↑, toxicity↓, ChemoSen↑, TumMeta↓, QoL↑,
7723- IP6,    Prostate cancer and inositol hexaphosphate: efficacy and mechanisms
- Review, Pca, NA
toxicity↓, AntiCan↑, TumCG↓, TumCCA↑, angioG↓,
7646- IP6,  Ins,    Protection against cancer by dietary IP6 and inositol
- Review, Var, NA
*antiOx↑, TumCG↓, TumMeta↓, Imm↑, kidSt↓, LDL↓, TumCCA↑, TumCP↓, Diff↑, ChemoSen↑, QoL↑,

Showing Research Papers: 601 to 650 of 1163
Prev Page 13 of 24 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1163

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 2,  

Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↑, 1,   antiOx↓, 6,   antiOx↑, 25,   antiOx⇅, 2,   ARE↑, 1,   ARE/EpRE↑, 1,   Catalase↓, 14,   Catalase↑, 7,   Copper↑, 1,   DJ-1↓, 1,   ENOX2↓, 1,   Fenton↑, 4,   GCLM↓, 1,   GPx↓, 3,   GPx↑, 5,   GPx1↓, 2,   GPx4↓, 20,   GPx4∅, 1,   GSH?, 1,   GSH↓, 65,   GSH↑, 10,   GSH⇅, 1,   GSH/GSSG↓, 3,   GSR↓, 2,   GSR↑, 1,   GSSG↓, 1,   GSTs↓, 4,   GSTs↑, 2,   GSTs↝, 1,   H2O2↓, 1,   H2O2↑, 10,   HO-1↓, 6,   HO-1↑, 25,   HO-2↓, 1,   Iron↓, 3,   Iron↑, 8,   Iron↝, 1,   i-Iron↑, 2,   c-Iron↑, 1,   Keap1↓, 1,   Keap1↑, 2,   lipid-P↓, 5,   lipid-P↑, 33,   MDA↓, 6,   MDA↑, 13,   i-MDA↑, 1,   NADH↓, 2,   mt-NADH↓, 1,   mt-NADH↑, 1,   NOX4↑, 1,   NQO1?, 1,   NQO1↓, 4,   NQO1↑, 4,   Nrf1↑, 1,   NRF2↓, 29,   NRF2↑, 34,   NRF2⇅, 1,   NRF2↝, 1,   Prx↓, 2,   Prx4↑, 1,   Prx6↑, 1,   PrxII↓, 2,   PYCR1↓, 1,   RNS↑, 2,   ROS?, 3,   ROS↓, 51,   ROS↑, 534,   ROS⇅, 11,   ROS↝, 4,   ROS∅, 4,   i-ROS?, 1,   i-ROS↓, 1,   i-ROS↑, 5,   mt-ROS↑, 9,   SOD?, 1,   SOD↓, 16,   SOD↑, 11,   SOD1↓, 2,   SOD1↑, 1,   SOD2↓, 5,   mt-SOD2↑, 1,   TBARS↓, 1,   TBARS↑, 1,   Thiols↓, 2,   TKT↓, 1,   Trx↓, 7,   Trx↑, 1,   Trx1↓, 1,   Trx1↑, 2,   ox-Trx1↑, 1,   TrxR↓, 12,   TrxR↑, 1,   TrxR1↓, 8,   TrxR1↑, 1,   xCT/SLC7A11↓, 5,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 2,   FTH1↓, 2,   IronCh↑, 3,   Mets↑, 1,   NCOA4↑, 1,   Tf↓, 1,   Tf↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↑, 1,   BCR↓, 1,   BCR-ABL↓, 1,   CDC16↓, 1,   CDC2↓, 12,   p‑CDC2↓, 1,   CDC25↓, 30,   CDC25↑, 2,   CDC25↝, 1,   p‑CDC25↑, 1,   compI↓, 4,   compII↓, 2,   compIII↓, 1,   compV↓, 1,   EGF↓, 6,   EGF↑, 1,   ETC↓, 7,   HSP60/HSPD1↓, 2,   HSP60/HSPD1↑, 1,   IDH2↓, 1,   Insulin↓, 1,   MFN2↑, 1,   mitResp↓, 6,   mitResp↑, 2,   MKK7↓, 1,   Mortalin↓, 1,   mtDam↓, 3,   mtDam↑, 44,   OCR↓, 6,   OCR↑, 2,   mt-OCR↑, 1,   OXPHOS↓, 5,   OXPHOS↑, 5,   mt-OXPHOS↓, 1,   mt-OXPHOS↑, 1,   PDH↓, 1,   PDH↑, 4,   PINK1↑, 1,   SIRT3↓, 3,   SIRT3↑, 3,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 6,   5LO↓, 5,   ACC↓, 1,   ACC↑, 3,   p‑ACC↑, 1,   ACLY↓, 2,   ACSL4↑, 2,   ALAT↓, 10,   ALDOA↓, 2,   AMP↓, 1,   AMP↑, 1,   AMPK?, 1,   AMPK↓, 3,   AMPK↑, 37,   AMPK↝, 1,   p‑AMPK↑, 2,   p‑AMT/GCST/T-protein↑, 1,   ATP↓, 40,   ATP↑, 1,   mt-ATP↓, 1,   CAIX/CA9↓, 4,   CholSyn↓, 1,   ECAR↓, 4,   ECAR↑, 1,   ECAR↝, 1,   ENO1↓, 3,   FABP4↓, 1,   FASN↓, 9,   G6PD↓, 2,   GAPDH↓, 2,   GLO-I↓, 2,   GLS↓, 2,   glucoNG↓, 1,   glucose↓, 1,   glucose↝, 1,   GlucoseCon↓, 18,   GlucoseCon∅, 1,   glut↓, 1,   GlutaM↓, 1,   GlutMet↓, 1,   Glycolysis↓, 51,   GSK‐3β↓, 15,   GSK‐3β↑, 9,   p‑GSK‐3β↓, 9,   H2S↑, 1,   Histones↑, 2,   HK1↓, 2,   HK2↓, 26,   HMG-CoA↓, 1,   IDH1↑, 1,   IDO1↓, 1,   lactateProd↓, 23,   lactateProd↑, 1,   lactateProd∅, 1,   LDHA↓, 17,   LDL↓, 4,   lipidLev↓, 1,   lipoGen↓, 1,   MCT4↓, 2,   NADPH↓, 4,   NADPH↑, 2,   PCK1↓, 1,   PDK1 / PDPK1?, 2,   PDK1 / PDPK1↓, 11,   PDK3↑, 1,   PDKs↓, 1,   PFK↓, 4,   PFK1↓, 1,   PGK1↓, 1,   PKM1↑, 1,   PKM2↓, 21,   PKM2↑, 1,   PKM2∅, 1,   PLA2↓, 1,   PPP↓, 2,   Pyrim↓, 1,   Pyruv↓, 1,   Pyruv↑, 1,   p‑S6↓, 2,   SCD1↓, 2,   SIRT1↓, 10,   SIRT1↑, 5,   SLC25A1↓, 1,   SREBF2↓, 1,   SREBP1/SREBF1↓, 2,   SREBP2↓, 1,   TCA↓, 2,   TCA↑, 1,   TS↓, 2,   Warburg↓, 10,  

Cell Death(tgid=5) ⓘ

AIF↑, 22,   APAF1↑, 11,   Apoptosis?, 2,   Apoptosis↓, 12,   Apoptosis↑, 657,   mt-Apoptosis↑, 11,   ASC↓, 1,   ASC↑, 1,   ASK1↑, 3,   p‑ASK1↑, 1,   BAD↓, 3,   BAD↑, 23,   p‑BAD↓, 1,   Bak↓, 1,   Bak↑, 14,   BAX↓, 6,   BAX↑, 251,   BAX↝, 3,   Bax:Bcl2↑, 67,   Bcl-2↓, 276,   Bcl-2↑, 8,   Bcl-2↝, 2,   Bcl-2∅, 1,   Bcl-xL↓, 70,   Bcl-xL↑, 1,   BID↓, 1,   BID↑, 12,   p‑BID↓, 1,   cl‑BID↑, 1,   BIM↑, 10,   BNIP3↑, 4,   BNIP3↝, 1,   BOK↑, 1,   BTG3↑, 1,   Casp↓, 4,   Casp↑, 73,   Casp↝, 2,   Casp∅, 1,   cl‑Casp↑, 3,   Casp1↓, 2,   Casp1↑, 3,   proCasp1↓, 1,   Casp10↓, 1,   Casp10↑, 3,   Casp12?, 1,   Casp12↑, 5,   cl‑Casp12↑, 2,   cl‑Casp12↝, 1,   Casp2↑, 2,   Casp3↓, 6,   Casp3↑, 295,   Casp3↝, 2,   cl‑Casp3↑, 65,   cl‑Casp3⇅, 1,   proCasp3↓, 3,   proCasp3↑, 3,   pro‑Casp3↑, 1,   CASP4↑, 1,   Casp6↓, 1,   Casp6↑, 3,   Casp7↑, 32,   cl‑Casp7↑, 7,   Casp8↓, 3,   Casp8↑, 66,   Casp8∅, 1,   cl‑Casp8↑, 11,   proCasp8↑, 3,   Casp9↓, 2,   Casp9↑, 171,   p‑Casp9↑, 1,   cl‑Casp9↑, 21,   proCasp9↓, 2,   proCasp9↑, 3,   cFLIP↓, 8,   Cyt‑c↓, 4,   Cyt‑c↑, 162,   Cyt‑c↝, 5,   mt-Cyt‑c↓, 1,   Diablo↑, 10,   DR5↓, 1,   DR5↑, 36,   Endon↑, 2,   FADD↑, 9,   Fap1↓, 1,   Fas↓, 1,   Fas↑, 34,   FasL↑, 18,   FasL⇅, 1,   Ferroptosis↑, 31,   GSDME↑, 1,   cl‑GSDME↑, 2,   HEY1↓, 1,   IAP1↓, 14,   IAP1↑, 1,   IAP2/BIRC3↓, 3,   IAP2/BIRC3↑, 1,   cl‑IAP2/BIRC3↑, 1,   ICAD↑, 1,   ICD↑, 1,   iNOS↓, 18,   iNOS↑, 1,   Mcl-1↓, 34,   Mcl-1↑, 1,   p‑Mcl-1↓, 1,   MDM2↓, 16,   MLKL↑, 2,   MOMP↓, 1,   MOMP↑, 8,   NAIP↓, 1,   Necroptosis↑, 6,   necrosis↑, 6,   NOXA↑, 6,   oncosis↑, 1,   P2X7↓, 1,   p38↓, 7,   p38↑, 31,   p‑p38↓, 5,   p‑p38↑, 7,   PUMA↓, 1,   PUMA↑, 10,   Pyro↑, 7,   RIP1↓, 2,   RIP3↑, 2,   p‑RIP3↑, 1,   survivin↓, 80,   TNFR 1↑, 2,   TRAIL↑, 6,   TRAILR↑, 2,   TumCD?, 1,   TumCD↓, 2,   TumCD↑, 61,   TUNEL↑, 2,   XIAP?, 1,   XIAP↓, 38,   XIAP↑, 1,   YAP/TEAD↓, 6,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 245,   Akt↑, 9,   Akt↝, 1,   p‑Akt↓, 69,   p‑Akt↑, 2,   AKT1↓, 6,   Akt2↓, 3,   AMPKα↑, 4,   BRAF↓, 1,   CaMKII ↓, 1,   CDC7↓, 1,   CIP2A↓, 1,   CK2↓, 7,   cMET↓, 3,   p‑cMET↑, 1,   CREB↓, 1,   cSrc↓, 2,   DDIT4↑, 1,   EF-1α↓, 1,   EGFR↓, 56,   EGFR↑, 1,   p‑EGFR↓, 6,   ERK↓, 67,   ERK↑, 18,   ERK↝, 2,   p‑ERK↓, 20,   p‑ERK↑, 7,   p‑ERK⇅, 1,   FGFR1↓, 4,   FGFR2↓, 1,   FOXD3↑, 1,   HCAR2↑, 1,   HER2/EBBR2↓, 23,   IGF-1R↓, 2,   IGFR↓, 3,   IKKα↓, 10,   p‑IKKα↓, 2,   IκB↓, 1,   IκB↑, 1,   p‑IκB↓, 2,   JAK↓, 7,   JAK1?, 1,   JAK1↓, 6,   JAK1↑, 1,   p‑JAK1↓, 2,   JAK2↓, 20,   p‑JAK2↓, 5,   p‑JAK3↓, 1,   JNK↓, 7,   JNK↑, 42,   JNK↝, 2,   p‑JNK↓, 4,   p‑JNK↑, 5,   LATS1↓, 1,   LIMK1↓, 1,   MAP2K1/MEK1↓, 1,   p‑MAP2K1/MEK1↓, 1,   MAPK?, 1,   MAPK↓, 57,   MAPK↑, 30,   MAPK↝, 4,   p‑MAPK↓, 2,   p‑MAPK↑, 2,   MARK4↓, 2,   MEK↓, 7,   p‑MEK↓, 2,   MKK4↓, 1,   MKP1↓, 1,   MKP2↓, 1,   Mst1↑, 1,   mTOR↓, 116,   mTOR↑, 3,   mTOR↝, 2,   p‑mTOR↓, 15,   mTORC2↓, 5,   p42↓, 1,   p70S6↓, 6,   p70S6↑, 1,   p‑p70S6↓, 1,   p‑p70S6↑, 1,   P70S6K↓, 7,   p‑P70S6K↓, 2,   p85S6K↓, 1,   P90RSK↓, 1,   p‑P90RSK↑, 1,   PDGFR-BB↓, 1,   PDGFRA↓, 1,   PDGFRB↓, 1,   PI3K↓, 176,   PI3K↑, 6,   PI3K↝, 2,   p‑PI3K↓, 8,   p‑PI3K↑, 1,   PI3K/Akt↓, 7,   PI3K/Akt↑, 1,   PI3k/Akt/mTOR↓, 6,   PIK3CA↓, 1,   PKA↓, 1,   PKCδ↓, 14,   PP2A↑, 1,   PRAS40↑, 1,   PRKCG↑, 1,   PTEN↓, 1,   PTEN↑, 33,   p‑PTEN↓, 1,   Raf↓, 5,   e-Raf↓, 1,   c-Raf↓, 1,   RAS↓, 17,   RET↓, 1,   RPS6KA1↓, 1,   p‑S6K↓, 1,   SHP1↓, 1,   SHP1↑, 3,   Sp1/3/4↓, 16,   Src↓, 1,   Src↑, 1,   STAT↓, 5,   STAT3↓, 120,   STAT3↑, 6,   STAT3↝, 1,   p‑STAT3↓, 28,   p‑STAT3↑, 2,   STAT5↓, 4,   STAT6↓, 4,   STK11/LKB1↑, 1,   p‑STK11/LKB1↑, 2,   THEM4/CTMP↑, 1,   TK1↓, 1,   TSC2↑, 4,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 2,   ATF2↓, 1,   ATF3↑, 2,   ATF4↓, 1,   ATF4↑, 19,   ATF4↝, 1,   p‑ATF4↝, 1,   ATFs↑, 1,   BRD4↓, 1,   CBP↓, 3,   CBP↑, 1,   ChrMod↑, 3,   ChrMod↝, 1,   cJun↓, 8,   cJun↑, 4,   p‑cJun↑, 1,   cMyc↓, 65,   cMyc↑, 2,   DNMT1↓, 15,   DNMT1↑, 1,   DNMT3A↓, 3,   DNMT3B↓, 2,   DNMTs↓, 11,   EZH2↓, 2,   FOXM1↓, 8,   FOXO↑, 1,   FOXO1↓, 2,   FOXO1↑, 3,   FOXO3↓, 8,   FOXO3↑, 8,   FOXO3↝, 1,   FOXO4↓, 2,   GATA3↓, 1,   H3↓, 2,   H3↑, 4,   p‑H3↓, 2,   p‑H3↑, 1,   ac‑H3↑, 10,   H3K27ac↓, 1,   H3K4↓, 1,   H4↑, 2,   ac‑H4↑, 7,   ac‑H4∅, 1,   HATs↓, 6,   HATs↑, 2,   HDAC↓, 48,   HDAC1↓, 9,   HDAC10↓, 1,   HDAC2↓, 7,   HDAC3↓, 7,   HDAC4↓, 2,   HDAC8↓, 4,   HMTs↓, 2,   JHDM1D-AS1↓, 1,   KLF4↓, 1,   miR-106b↓, 1,   miR-107↑, 2,   miR-122-5p↑, 1,   miR-126↑, 1,   miR-133a-3p↑, 1,   miR-134↑, 1,   miR-139-5p↑, 2,   miR-149↑, 1,   miR-155↓, 4,   miR-195↑, 1,   miR-199↓, 1,   miR-199↑, 1,   miR-19b↓, 1,   miR-203↓, 1,   miR-203↑, 1,   miR-206↑, 1,   miR-21↓, 8,   miR-21↑, 2,   miR-210↑, 1,   miR-215-5p↑, 1,   miR-218↑, 1,   miR-22↑, 1,   miR-221↑, 1,   miR-222↑, 1,   miR-224↓, 2,   miR-25-5p↓, 1,   miR-27a-3p↓, 2,   miR-29b↑, 1,   miR-30a-5p↑, 1,   miR-326-5p↑, 1,   miR-339-5p↑, 1,   miR-339-5p↝, 1,   miR-340↓, 2,   miR-34a↑, 11,   miR-34b-5p↑, 1,   miR-384↑, 1,   miR-422a↑, 2,   MTA2↓, 1,   Myc↓, 6,   Myc↑, 1,   MYCN↓, 1,   n-MYC↓, 2,   NDRG1↑, 1,   NNMT↓, 1,   OCT4↓, 16,   other?, 2,   other↓, 9,   other↑, 7,   other↝, 25,   other∅, 2,   OV6↓, 1,   PAX2↓, 1,   PCAF↓, 1,   PhotoS↑, 4,   PRC2↓, 1,   PRMT6↓, 1,   SBF2-AS1↓, 1,   Set9↑, 1,   sonoS↑, 1,   SOX2↓, 15,   SOX4↓, 4,   SOX4↑, 1,   SUV39H↓, 3,   TBX3↑, 1,   TCF-4↓, 2,   TFE3↑, 1,   tumCV?, 2,   tumCV↓, 152,   tumCV↑, 1,   tumCV∅, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 2,   cl‑ATF6↑, 1,   CHOP/DDIT3↑, 41,   p‑CHOP/DDIT3↝, 1,   cl‑CHOP/DDIT3↑, 1,   EDEM↑, 1,   eIF2α↓, 3,   eIF2α↑, 11,   p‑eIF2α↑, 6,   p‑eIF2α↝, 1,   ER Stress↓, 4,   ER Stress↑, 85,   ER Stress↝, 1,   ERStress↑, 1,   GRP78/BiP?, 1,   GRP78/BiP↓, 3,   GRP78/BiP↑, 19,   GRP94↑, 1,   HSF1↓, 2,   HSP27↓, 8,   HSP27↑, 3,   HSP27↝, 1,   HSP70/HSPA5↓, 8,   HSP70/HSPA5↑, 5,   HSP70/HSPA5↝, 1,   HSP90↓, 24,   HSP90↑, 2,   HSPs↓, 3,   IRE1↑, 4,   PDI↑, 1,   PERK↓, 1,   PERK↑, 12,   p‑PERK↑, 1,   p‑PERK↝, 1,   UPR↑, 16,   XBP-1↑, 2,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG13↑, 2,   ATG16L1↑, 1,   ATG3↑, 2,   ATG5↓, 1,   ATG5↑, 11,   ATG7↑, 2,   AVOs↑, 1,   Beclin-1/ATG6↓, 6,   Beclin-1/ATG6↑, 20,   CTSB↓, 2,   CTSD↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 4,   LC3A↑, 2,   LC3B↓, 1,   LC3B↑, 2,   LC3B-II↓, 1,   LC3B-II↑, 4,   LC3II↓, 2,   LC3II↑, 13,   LC3s↑, 2,   LC3s↝, 1,   MitoP↓, 1,   p62↓, 9,   p62↑, 7,   PARK2↑, 1,   RUBCN↓, 1,   SESN2↑, 4,   TumAuto↓, 4,   TumAuto↑, 84,   TumAuto⇅, 1,   TumAuto↝, 2,   ULK1/ATG1↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 11,   p‑ATM↑, 2,   ATR↑, 4,   p‑ATR↑, 1,   BRCA1↓, 1,   BRCA1↑, 3,   p‑BRCA1↑, 1,   BRCA2↓, 1,   BRCA2↑, 1,   CUL4B↑, 1,   DFF45↑, 2,   DNA-PK↑, 1,   DNAdam↓, 6,   DNAdam↑, 160,   mt-DNAdam↑, 1,   DNArepair↓, 8,   ERCC3↑, 1,   m-FAM72A↓, 1,   G9a↓, 2,   HR↓, 1,   hTERT/TERT↓, 17,   MDMX↓, 1,   MGMT↓, 2,   MSH2↑, 1,   NHEJ↓, 1,   p16↑, 7,   P53?, 1,   P53↓, 9,   P53↑, 213,   P53↝, 3,   p‑P53↓, 2,   p‑P53↑, 5,   ac‑P53↑, 1,   p53 Wildtype↓, 1,   p53 Wildtype∅, 1,   p73↑, 1,   PARP↓, 9,   PARP↑, 36,   PARP↝, 1,   p‑PARP↑, 1,   cl‑PARP↓, 2,   cl‑PARP↑, 143,   PARP1↓, 1,   PARP1↑, 5,   cl‑PARP1↑, 3,   PCNA↓, 48,   PCNA↑, 1,   PCNA↝, 1,   POLD1↓, 1,   RAD51↓, 1,   SIRT6↓, 3,   SIRT6↑, 1,   Telomerase↓, 15,   TOP1?, 1,   TOP1↓, 8,   TOP2↓, 7,   TP53↑, 4,   TRF2↓, 2,   UHRF1↓, 2,   XRCC1↓, 1,   γH2AX↑, 26,   γH2AX↝, 1,   p‑γH2AX↑, 3,  

Cell Cycle & Senescence(tgid=11) ⓘ

ANAPC2↑, 1,   AURKB↑, 1,   BRD4↓, 1,   CC(CDKs/cyclins)↓, 2,   CDK1↓, 45,   CDK1↑, 7,   CDK1↝, 1,   p‑CDK1↓, 1,   CDK1/2/5/9∅, 1,   CDK2↓, 90,   CDK2↑, 6,   p‑CDK2↓, 1,   CDK4↓, 114,   CDK4↑, 5,   p‑CDK4↓, 1,   CDK4/6↓, 3,   CDK6↓, 35,   CDK6↑, 6,   CDK8↓, 2,   CDKN1C/p57↓, 1,   CDKN1C/p57↑, 1,   CDKN2C/p18↑, 2,   cellSen↑, 2,   CHK1↓, 4,   CHK1↑, 4,   CHK1↝, 1,   p‑CHK1↑, 4,   Chk2↓, 2,   Chk2↑, 9,   p‑Chk2↑, 2,   ChrCon↑, 1,   Cyc↓, 8,   cycA1/CCNA1↓, 33,   cycA1/CCNA1↑, 5,   CycB/CCNB1↓, 74,   CycB/CCNB1↑, 10,   CycB/CCNB1↝, 1,   cycD1/CCND1↓, 220,   cycD1/CCND1↑, 6,   cycD1/CCND1↝, 1,   p‑cycD1/CCND1↓, 1,   CycD3↓, 4,   CycD3↑, 1,   cycE/CCNE↓, 63,   cycE/CCNE↑, 5,   cycE1↓, 4,   cycF↓, 1,   cycF↑, 1,   E2F4↑, 1,   E2Fs↓, 10,   FBXO5/EMI1↓, 1,   GADD45A↑, 5,   Ki-67↓, 49,   mitA↑, 4,   p19↑, 3,   P21?, 2,   P21↓, 10,   P21↑, 193,   P21↝, 1,   p27/CDKN1B↓, 7,   p27/CDKN1B↑, 75,   cl‑p27/CDKN1B↓, 1,   PLK1↓, 1,   pRB↓, 5,   pRB↑, 1,   p‑pRB↓, 7,   RB1↑, 6,   p‑RB1↓, 10,   cl‑RB1↓, 1,   Securin↓, 2,   TumCCA?, 8,   TumCCA↓, 29,   TumCCA↑, 1128,   TumCCA⇅, 1,   TumCCA∅, 1,   WEE1↑, 3,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

4E-BP1↓, 3,   p‑4E-BP1↓, 2,   ALDH↓, 5,   ALDH1A1↓, 4,   AXIN1↓, 1,   Axin2↓, 1,   Axin2↑, 1,   BMI1↓, 1,   BMP7/OP1↓, 3,   BMPs↑, 1,   CD133↓, 17,   CD24↓, 3,   CEBPA↑, 1,   cFos↓, 6,   cFos↑, 1,   cMYB↓, 3,   CSCs?, 1,   CSCs↓, 68,   CSCs↑, 1,   Diff↓, 1,   Diff↑, 7,   EIF4E↓, 2,   EP300↑, 1,   EP4/PTGER4↑, 1,   FGF↓, 4,   Gli1↓, 12,   HH?, 1,   HH↓, 12,   HMGCR↓, 3,   IGF-1?, 1,   IGF-1↓, 12,   IGF-1↑, 1,   p‑IGF-1↓, 1,   IGFBP3↑, 4,   IGFBP7↑, 1,   p‑Jun↓, 1,   Ki-67↓, 49,   Let-7↑, 5,   LGR5↓, 1,   mTORC1↓, 6,   p‑mTORC1↓, 1,   Nanog↓, 17,   Nestin↓, 3,   NF2↑, 1,   NKD2↑, 1,   NOTCH↓, 22,   NOTCH1↓, 17,   NOTCH1↑, 3,   NOTCH2↓, 1,   NOTCH3↓, 4,   OGFr↑, 1,   p300↓, 5,   PTCH1↓, 1,   SAL↑, 1,   SCF↓, 1,   Shh↓, 15,   Smo↓, 5,   Smo∅, 1,   STAT1↓, 1,   Sufu↑, 1,   TOPflash↓, 1,   TumCG?, 4,   TumCG↓, 244,   TumCG↑, 3,   TumCP?, 2,   TumCP↓, 396,   TumCP↑, 8,   tyrosinase↓, 2,   URGCP/URG4↓, 1,   Wnt↓, 60,   Wnt↝, 1,   Wnt/(β-catenin)↓, 15,   ZFX↓, 1,  

Migration(tgid=13) ⓘ

67LR↓, 1,   annexin II↓, 1,   AntiAg↓, 1,   AntiAg↑, 3,   AP-1↓, 17,   APC↑, 1,   ATPase↓, 2,   AXL↓, 1,   BACH1↓, 1,   CA↓, 2,   Ca+2↓, 3,   Ca+2↑, 57,   Ca+2↝, 4,   i-Ca+2↑, 4,   CAFs/TAFs↓, 1,   cal2↑, 2,   CCN2/CTGF↓, 2,   CD11b↑, 1,   Cdc42↑, 1,   Chl↑, 1,   Cofilin↓, 2,   COL1↓, 1,   COL1A1↓, 1,   COL3A1↓, 2,   E-cadherin↓, 12,   E-cadherin↑, 58,   E-cadherin↝, 1,   EMT?, 1,   EMT↓, 104,   EMT↑, 2,   EMT↝, 1,   EpCAM↓, 6,   F-actin↓, 2,   FAK↓, 19,   FAK↑, 1,   p‑FAK↓, 7,   p‑FAK↑, 1,   fascin↓, 1,   Fibronectin↓, 3,   GIT1↓, 1,   GLI2↓, 1,   ITGA5↓, 2,   ITGB1↓, 2,   ITGB1↑, 1,   ITGB4↓, 2,   KRAS↓, 2,   LAMs↓, 3,   LEF1↓, 3,   MALAT1↓, 1,   MET↓, 2,   MMP-10↓, 2,   MMP1↓, 8,   MMP13↓, 3,   MMP16↓, 2,   MMP2↓, 124,   MMP3↓, 10,   MMP7↓, 14,   MMP9↓, 152,   MMP9↑, 2,   MMP9:TIMP1↓, 1,   MMPs↓, 47,   MTA1↓, 1,   MUC1↓, 1,   MUC1-C↓, 1,   MUC4↓, 4,   N-cadherin?, 1,   N-cadherin↓, 36,   N-cadherin↑, 1,   N-cadherin↝, 1,   NCAM↓, 2,   NCAM↑, 1,   NEDD9↓, 2,   NFAT↑, 1,   p44↓, 1,   PAK1↓, 3,   pax↓, 1,   p‑pax↓, 1,   PCBP1↓, 1,   PDGF↓, 6,   Rac1↓, 1,   RECK↑, 1,   Rho↓, 3,   ROCK1↓, 7,   ROCK1↑, 1,   Slug?, 1,   Slug↓, 9,   Smad1↓, 1,   Smad1↑, 1,   Smad1↝, 1,   SMAD2↓, 4,   p‑SMAD2↓, 1,   SMAD3↓, 6,   SMAD3↑, 1,   p‑SMAD4↓, 1,   Snail?, 1,   Snail↓, 21,   STAC2↓, 1,   T-cadherin↑, 1,   TET1↓, 1,   TET1↑, 5,   TGF-β↓, 24,   TGF-β↑, 1,   TGF-β↝, 1,   TGF-β1↓, 1,   THBS1↓, 1,   THBS1↑, 1,   TIMP1↓, 2,   TIMP1↑, 11,   TIMP2↓, 3,   TIMP2↑, 12,   TPM4↓, 1,   pol-TregCell↓, 1,   TRIB3↑, 1,   Trop2↓, 1,   TSC1↑, 2,   TSP-1↑, 4,   TumCA↓, 1,   TumCI↓, 152,   TumCI↑, 2,   TumCMig?, 1,   TumCMig↓, 161,   TumCMig↑, 2,   TumMeta↓, 129,   TumMeta↑, 9,   Twist↓, 18,   TXNIP↑, 1,   uPA↓, 25,   uPAR↓, 4,   Vim?, 1,   Vim↓, 42,   Vim↑, 1,   Zeb1↓, 13,   ZEB2↓, 2,   α-SMA↓, 2,   α-tubulin↓, 4,   β-catenin/ZEB1↓, 74,   β-catenin/ZEB1↑, 3,   p‑β-catenin/ZEB1↓, 1,   cl‑β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 160,   angioG↑, 3,   CCN1/CYR61↓, 1,   CD31/PECAM-1↓, 5,   ECM/TCF↓, 1,   EGR1↓, 1,   Endoglin↑, 2,   eNOS↓, 3,   HIF-1↓, 10,   Hif1a↓, 90,   Hif1a↑, 2,   LOX1↓, 2,   NO↓, 6,   NO↑, 7,   VCAM-1↓, 3,   VEGF↓, 153,   VEGF↑, 1,   VEGFR1↓, 3,   VEGFR2/KDR/Flk1↓, 23,   p‑VEGFR2/KDR/Flk1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

AQPs↓, 1,   BBB↑, 7,   BBB∅, 1,   CellMemb↑, 1,   CLDN1↓, 2,   CLDN1↑, 1,   CLDN2↓, 2,   CTR1↑, 1,   EPR↑, 14,   GLUT1↓, 16,   GLUT2↓, 2,   GLUT4↓, 6,   IBI↑, 1,   memfluid↓, 1,   MMP?, 1,   MMP↓, 264,   MMP↑, 3,   MMP∅, 1,   MPT↑, 9,   NHE1↓, 2,   OATPs↓, 2,   OCLN↑, 1,   SLC12A5↓, 1,   SVCT-2∅, 1,   TJ↑, 1,   TRPM7↓, 3,   TRPM7↑, 1,   TRPV1↑, 4,   TRPV1↝, 1,   ZO-1↓, 1,   ZO-1↑, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

B2M↓, 1,   CB2 / CNR2↑, 3,   CCR7↓, 1,   CD155↓, 1,   CD25+↑, 1,   CD4+↓, 1,   CD4+↑, 4,   CD44↓, 20,   CD44↝, 1,   CD47↓, 1,   CD8+↑, 4,   cDC2↓, 8,   p‑cDC2↓, 2,   p‑cDC2↑, 1,   COX1↓, 2,   COX2/PTGS2↓, 109,   COX2/PTGS2↑, 4,   COX2/PTGS2↝, 2,   CXCL12↓, 2,   CXCL9↓, 1,   CXCR2↓, 2,   CXCR2↑, 1,   CXCR4↓, 13,   DCells↑, 2,   DR4↑, 9,   DR4∅, 1,   DR6↑, 1,   FOXP3↓, 1,   FOXP3↑, 2,   Gal-3↓, 2,   HCAR2↑, 1,   HMGB1↓, 5,   ICAM-1↓, 6,   IFN-γ↓, 6,   IFN-γ↑, 2,   Igs↑, 2,   IL1↓, 7,   IL1↑, 1,   IL10↓, 3,   IL10↑, 3,   IL12↑, 1,   IL13↓, 1,   IL17↓, 1,   IL1α↓, 1,   IL1β↓, 21,   IL1β↑, 1,   IL2↓, 3,   IL2↑, 4,   IL4↓, 1,   IL4↑, 1,   IL6↓, 53,   IL6↑, 1,   IL8↓, 12,   IL8↑, 1,   Imm↑, 28,   Imm↝, 3,   Inflam↓, 53,   Inflam↝, 1,   IRAK1↓, 1,   M2 MC↓, 1,   MCP1/CCL2↓, 3,   MCT1↓, 2,   MIP2↓, 1,   MyD88↑, 1,   NAF1↓, 1,   NF-kB?, 1,   NF-kB↓, 220,   NF-kB↑, 8,   NF-kB↝, 1,   p‑NF-kB↓, 2,   p‑NF-kB↑, 2,   NK cell↑, 11,   NLRP3↓, 3,   NLRP3↑, 2,   NOD1↓, 1,   p65↓, 9,   p65↑, 1,   p‑p65↓, 4,   ac‑p65↓, 1,   ac‑p65↑, 2,   PD-1↓, 2,   PD-L1↓, 12,   PD-L1↑, 3,   PGE2↓, 22,   PSA↓, 20,   PSA∅, 1,   RAGE↓, 2,   SOCS-3↓, 1,   SOCS-3↑, 1,   T-Cell↑, 2,   TCF↓, 4,   Th1 response?, 1,   Th1 response↑, 1,   TLR4↓, 5,   TLR4↑, 1,   TLR4↝, 1,   TNF-α↓, 41,   TNF-α↑, 8,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 4,   TRADD↑, 1,   Treg lymp↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

ADAM17↓, 1,   pH↓, 1,   i-pH↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   CAXII/CA12↑, 1,   PTN↓, 1,  

Protein Aggregation(tgid=19) ⓘ

APOE4↑, 1,   BACE/β-secretase↓, 1,   PSEN1/PS1↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

2/16-OHE1↑, 1,   4-OHE1↓, 1,   6IL↑, 1,   ACE/ACE1↓, 1,   AhR↓, 2,   AhR↑, 1,   AR↓, 22,   AR↑, 1,   COMT↓, 1,   ER-α36↓, 4,   ER(estro)↓, 2,   ER(estro)↑, 1,   ERα/ESR1↓, 3,   ERβ/ESR2↑, 1,   Estro↝, 1,   EstroRS/ERS↓, 1,   FGF21↓, 1,   GR↑, 1,   PPARγ↓, 2,   PPARγ↑, 9,   PRL↓, 1,   RANKL↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 3,   AKR1B10↓, 1,   BioAv↓, 63,   BioAv↑, 58,   BioAv↝, 12,   BioEnh↑, 6,   CBR1↓, 1,   chemoR↓, 1,   ChemoSen↓, 4,   ChemoSen↑, 271,   ChemoSen∅, 1,   CompStab?, 1,   CompStab↓, 1,   CompStab↑, 4,   CompStab↝, 1,   CYP1A1↓, 5,   CYP1A1↑, 3,   CYP1A2↓, 1,   CYP1B1↓, 1,   CYP3A4↓, 2,   DDS↑, 1,   Dose?, 5,   Dose↓, 3,   Dose↑, 10,   Dose⇅, 3,   Dose↝, 98,   Dose∅, 12,   eff↓, 110,   eff↑, 148,   eff↝, 17,   eff∅, 3,   GSTA1↓, 2,   GSTA1↑, 1,   GSTP1/GSTπ↓, 1,   Half-Life↓, 19,   Half-Life↑, 4,   Half-Life↝, 16,   Half-Life∅, 2,   MDR1↓, 13,   MRP1/ABCC1↓, 6,   NAT↓, 1,   P-gp/ABCB1↓, 31,   P-gp/ABCB1∅, 1,   P450↓, 5,   P450↝, 1,   RadioS?, 1,   RadioS↓, 1,   RadioS↑, 84,   RadioS↝, 1,   selectivity?, 4,   selectivity↓, 2,   selectivity↑, 190,   selectivity∅, 1,   Synergy↑, 136,  

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 1,   ALAT↓, 10,   ALP↓, 4,   AR↓, 22,   AR↑, 1,   AST↓, 7,   B2M↓, 1,   BRAF↓, 1,   BRCA1↓, 1,   BRCA1↑, 3,   p‑BRCA1↑, 1,   CEA↓, 1,   CRP↓, 2,   E6↓, 4,   E7↓, 3,   EGFR↓, 56,   EGFR↑, 1,   p‑EGFR↓, 6,   ERα/ESR1↓, 3,   EstroRS/ERS↓, 1,   EZH2↓, 2,   Ferritin↓, 2,   FOXM1↓, 8,   HER2/EBBR2↓, 23,   hTERT/TERT↓, 17,   IL6↓, 53,   IL6↑, 1,   KRAS↓, 2,   LDH↓, 9,   LDH↑, 6,   LDH↝, 3,   i-LDH↓, 1,   Maspin↑, 1,   Myc↓, 6,   Myc↑, 1,   PD-L1↓, 12,   PD-L1↑, 3,   PSA↓, 20,   PSA∅, 1,   RAGE↓, 2,   TP53↑, 4,   TRIB3↑, 1,   Tumccf↓, 1,   XIST↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiCan↓, 3,   AntiCan↑, 107,   AntiCan?, 1,   AntiDiabetic↑, 2,   antiNeop↑, 4,   AntiTum↓, 1,   AntiTum↑, 40,   Appetite↑, 1,   BowelM↑, 1,   breath↑, 1,   cachexia↓, 1,   cardioP↑, 13,   CardioT↓, 2,   CardioT↑, 2,   chemoP↑, 43,   chemoPv↑, 33,   ChemoSideEff↓, 6,   cognitive↑, 1,   fatigue↓, 1,   fatigue∅, 1,   FTO↑, 1,   hepatoP↓, 2,   hepatoP↑, 15,   hepatoP∅, 1,   K17↓, 1,   kidSt↓, 1,   memory↑, 1,   Mucositis↓, 1,   neuroP↑, 14,   NP/CIPN↓, 1,   Obesity↓, 1,   Obesity↑, 1,   OS?, 1,   OS↑, 26,   OS⇅, 1,   Pain↓, 4,   PFS↑, 1,   Pin1↓, 3,   QoL↑, 10,   QoL∅, 2,   radioP↑, 11,   Remission↑, 1,   RenoP↑, 8,   Risk↓, 25,   Sleep↑, 2,   Strength↑, 2,   TGFβR1↑, 1,   toxicity?, 1,   toxicity↓, 31,   toxicity↑, 6,   toxicity↝, 9,   toxicity∅, 5,   TumVol↓, 50,   TumVol↑, 2,   TumVol∅, 1,   TumW↓, 21,   TumW∅, 1,   Weight↑, 3,   Weight∅, 2,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↓, 1,   AntiFungal↑, 1,   AntiViral↑, 1,   Bacteria↓, 4,   Bacteria↑, 1,   GutMicro↑, 8,   GutMicro↝, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,   Ingr↝, 5,  
Total Targets: 1394

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx?, 1,   antiOx↓, 6,   antiOx↑, 126,   mt-antiOx↑, 1,   ARE↑, 2,   Catalase↑, 48,   Copper↓, 1,   GPx↓, 1,   GPx↑, 35,   GPx1↑, 1,   GPx4↑, 2,   GSH↑, 40,   GSR↑, 6,   GSSG↓, 1,   GSTs↑, 21,   H2O2↓, 3,   HDL↓, 1,   HDL↑, 4,   HNE↓, 1,   HO-1↓, 1,   HO-1↑, 21,   Iron↓, 2,   i-Iron↓, 1,   Keap1↓, 3,   Keap1↑, 1,   Keap1↝, 1,   lipid-P↓, 44,   MDA↓, 33,   MPO↓, 5,   NADH↓, 1,   NOX4↓, 1,   NQO1↑, 4,   Nrf1↑, 1,   NRF2↓, 1,   NRF2↑, 51,   Prx↑, 1,   RNS↓, 3,   ROS?, 2,   ROS↓, 117,   ROS↑, 8,   ROS↝, 1,   ROS∅, 4,   mt-ROS?, 1,   selenoP↑, 1,   SOD↓, 1,   SOD↑, 51,   SOD1↑, 3,   SOD2↑, 1,   TAC↑, 6,   TBARS↓, 3,   Trx1↑, 1,   uricA↓, 2,   VitC↑, 2,   xCT/SLC7A11↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↓, 1,   IronCh↑, 4,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

DRP1/DNM1L↓, 1,   HSP60/HSPD1↓, 1,   Insulin↓, 1,   Insulin↑, 2,   MFN2↑, 1,   mitResp↑, 1,   OCR↑, 1,   PGC-1α↑, 1,   PGC-1α↝, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

15-LOX/ALOX15↓, 1,   5LO↓, 4,   ALAT↓, 12,   AMPK↑, 9,   p‑AMPK↑, 1,   ATP↑, 4,   CRM↑, 1,   DGAT1↓, 1,   ECAR↓, 1,   ECAR∅, 1,   FASN↓, 2,   glucose↓, 6,   glucose↝, 1,   GlucoseCon↑, 2,   glyC↓, 1,   Glycolysis↓, 1,   Glycolysis↑, 1,   GSK‐3β↓, 4,   GSK‐3β↑, 2,   H2S↑, 2,   HK2↑, 1,   LDHA↑, 1,   LDL↓, 6,   lipidLev↓, 2,   NADPH↑, 2,   SIRT1↑, 4,   SIRT1↝, 1,  

Cell Death(tgid=5) ⓘ

AIF↓, 1,   AIF↑, 1,   Apoptosis↓, 6,   Apoptosis↑, 1,   ASC↓, 1,   BAX↓, 8,   BAX↑, 1,   Bax:Bcl2↑, 2,   Bcl-2↓, 1,   Bcl-2↑, 4,   Casp↓, 1,   Casp1↓, 1,   Casp3?, 1,   Casp3↓, 11,   Casp3↑, 2,   cl‑Casp3↑, 1,   Casp8↑, 1,   cl‑Casp8↑, 2,   Casp9↓, 3,   Casp9↑, 1,   cl‑Casp9↑, 1,   Cyt‑c↓, 4,   Cyt‑c↑, 1,   Fas↓, 2,   Fas↑, 2,   FasL↓, 1,   Ferroptosis↓, 3,   IAP1↓, 1,   iNOS↓, 18,   iNOS↑, 1,   necrosis↓, 1,   p38↓, 1,   p38↑, 1,   survivin↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 4,   Akt↑, 3,   Akt↝, 1,   p‑Akt↑, 1,   p‑CREB↑, 1,   ERK↓, 2,   ERK↑, 2,   p‑ERK↑, 1,   IκB?, 1,   JAK↓, 1,   JNK↓, 3,   JNK↑, 3,   MAPK↓, 8,   MAPK↑, 1,   mTOR↓, 3,   mTOR↑, 2,   PDGFR-BB↓, 1,   PDGFRB↓, 1,   PI3K↓, 6,   PI3K↑, 2,   PKCδ↓, 1,   PTEN↑, 1,   STAT↓, 3,   STAT3↓, 2,   STAT3↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 5,   ATF2↑, 1,   cJun↓, 1,   cMyc↓, 1,   p‑cMyc↑, 1,   FOXO3↑, 1,   HDAC↓, 1,   HDAC3↓, 1,   other?, 1,   other↓, 2,   other↑, 5,   other↝, 7,   RUNX2↑, 1,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 1,   cl‑eIF2α↑, 1,   GRP78/BiP↑, 1,   HSP27↓, 1,   HSP70/HSPA5↓, 1,   HSP70/HSPA5↑, 3,   HSPs↑, 1,   p‑PERK↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 2,   Beclin-1/ATG6↑, 1,   LC3II↑, 1,   p62↑, 2,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 5,   DNArepair↑, 1,   p16↓, 1,   P53↓, 3,   P53↑, 4,   PARP↑, 1,   cl‑PARP↑, 2,   PARP1↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1,   CDK2↓, 1,   cycA1/CCNA1↓, 1,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 2,   cycE/CCNE↑, 1,   Ki-67↓, 1,   P21↓, 3,   P21↑, 5,   TumCCA↑, 9,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMP2↑, 1,   Diff↑, 1,   Diff↝, 1,   HH↓, 1,   IGF-1↓, 1,   IGFBP3↑, 1,   Ki-67↓, 1,   neuroG↑, 1,   TumCP↓, 2,   Wnt↑, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 12,   AP-1↓, 3,   BACH1↓, 1,   Ca+2↓, 2,   Ca+2↑, 1,   Ca+2↝, 1,   Cartilage↑, 1,   COL1↑, 1,   FAK↑, 1,   LAMs↑, 1,   LRP1↑, 1,   MMP13↓, 2,   MMP9↓, 5,   MUC1↑, 1,   Smad1↑, 1,   TGF-β↓, 4,   TIMP1↓, 1,   TregCell↑, 1,   TumCI↓, 1,   TumCI∅, 1,   TumCMig∅, 1,   α-SMA↓, 1,   β-catenin/ZEB1↑, 1,   β-catenin/ZEB1↝, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 2,   angioG↑, 1,   E-sel↓, 1,   Hif1a↓, 2,   NO↓, 10,   NO↑, 1,   VCAM-1↓, 3,   VEGF↓, 3,   VEGF↑, 2,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 9,   BBB↝, 2,   GastroP↑, 6,   GLUT4↑, 2,   H+/K+-ATPase↓, 1,   IBI↑, 3,   MMP↓, 3,   MMP↑, 9,   MMP∅, 1,   MUC5AC↓, 1,   TRPA1↑, 1,   TRPC1↓, 1,   TRPM7↓, 1,   TRPV1↑, 1,   VGSC↓, 1,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CCL11↓, 1,   CD19↑, 1,   CD4+↑, 2,   CD8+↑, 1,   COX1↓, 4,   COX2/PTGS2↓, 35,   COX2/PTGS2↑, 1,   CXCR4↓, 1,   HMGB1↓, 1,   ICAM-1↓, 2,   IFN-γ↓, 3,   IFN-γ↑, 2,   IL1↓, 2,   IL10↓, 3,   IL10↑, 5,   IL12↓, 1,   IL17↓, 5,   IL18↓, 3,   IL1β↓, 21,   IL2↓, 1,   IL2↑, 1,   IL22↓, 1,   IL23↓, 1,   IL5↓, 1,   IL6?, 1,   IL6↓, 29,   IL6↑, 1,   IL8↓, 8,   Imm↑, 6,   Imm⇅, 2,   Inflam?, 1,   Inflam↓, 121,   Inflam↑, 4,   IRF3↓, 2,   pol-M2 MC↑, 1,   MCP1/CCL2↓, 2,   MyD88↓, 2,   NeuroI↓, 1,   NF-kB?, 1,   NF-kB↓, 41,   NF-kB↑, 1,   NK cell↑, 1,   NLRP3↓, 5,   NLRP3↑, 1,   PGE2↓, 15,   PGE2↑, 1,   RAGE↓, 2,   SOCS-3↓, 1,   TLR2↓, 3,   TLR4↓, 7,   TNF-α?, 1,   TNF-α↓, 37,   TNF-α↑, 2,   TRIF↓, 1,   β-HEX↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 2,   5HT↑, 2,   AChE↓, 17,   AChE↑, 1,   BChE↓, 3,   BDNF↑, 10,   GABA↑, 3,   GABA↝, 1,   MAOA↓, 2,   NGF↑, 3,   TPH1↓, 1,   TrkB↑, 2,   β-Endo↑, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 5,   Aβ↓, 19,   BACE/β-secretase↓, 6,   tau↓, 4,   p‑tau↓, 3,   XO↓, 2,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 1,   ACE2↓, 1,   AHR↓, 1,   CYP19↓, 1,   GPER↑, 1,   GR↑, 1,   PPARα↝, 1,   PPARγ↓, 2,   PPARγ↑, 2,   p‑PPARγ↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv?, 1,   BioAv↓, 50,   BioAv↑, 45,   BioAv↝, 22,   BioEnh↑, 2,   ChemoSen↑, 1,   CompStab↑, 1,   CompStab↝, 2,   CYP1A1↑, 1,   CYP1A2↑, 1,   CYP2D6↓, 1,   CYP2E1↓, 1,   Dose↑, 1,   Dose⇅, 1,   Dose↝, 10,   eff↓, 1,   eff↑, 11,   eff↝, 2,   GSTA1↓, 1,   GSTA1↑, 2,   Half-Life↓, 3,   Half-Life↑, 2,   Half-Life↝, 11,   Half-Life∅, 2,   P450↓, 3,   Synergy↑, 13,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 12,   ALP↓, 4,   AST↓, 15,   BloodF↑, 1,   BMD↑, 5,   BP↓, 9,   creat↓, 4,   CRP↓, 3,   HOMA↓, 1,   hs-CRP↓, 1,   IL6?, 1,   IL6↓, 29,   IL6↑, 1,   IRes↑, 1,   IRes↝, 1,   LDH↓, 7,   NOS2↓, 1,   RAGE↓, 2,   TC↓, 2,   TG/TAG↓, 2,   Urea↓, 1,   VLDL↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 7,   antiAll↑, 18,   AntiArt↑, 9,   AntiCan↓, 2,   AntiCan↑, 25,   antiCG↑, 1,   AntiDiabetic↓, 2,   AntiDiabetic↑, 31,   antiNeop↑, 2,   antiPs↑, 1,   AntiTum↓, 2,   AntiTum↑, 3,   Bone Healing↑, 1,   cardioP?, 1,   cardioP↓, 1,   cardioP↑, 53,   CardioT↓, 1,   chemoP↑, 10,   chemoPv↑, 7,   cognitive↑, 17,   cough?, 1,   diuretic↑, 1,   hepatoP↑, 43,   Learn↑, 1,   memory↑, 19,   motorD↑, 3,   Mucositis↓, 1,   neuroP↓, 1,   neuroP↑, 82,   Obesity↓, 15,   OS↑, 1,   Pain↓, 9,   radioP↑, 4,   RenoP↓, 1,   RenoP↑, 12,   Risk↓, 1,   SoreThr?, 1,   Stress↓, 2,   Stroke↓, 11,   toxicity?, 2,   toxicity↓, 56,   toxicity↑, 6,   toxicity↝, 11,   toxicity∅, 10,   Wound Healing↑, 4,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 17,   AntiFungal↓, 2,   AntiFungal↑, 7,   AntiP↓, 1,   AntiP↑, 4,   AntiViral↑, 13,   Bacteria↓, 28,   Diar↓, 3,   GutMicro↑, 15,   Sepsis↓, 2,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↑, 1,   Ingr↝, 6,  
Total Targets: 443

Scientific Paper Hit Count for: TumCCA, Tumor cell cycle arrest
41 Curcumin
31 Quercetin
30 Silver-NanoParticles
26 Sulforaphane (mainly Broccoli)
25 Thymoquinone
23 Apigenin (mainly Parsley)
22 Berberine
21 Fisetin
21 Kaempferol
18 Radiotherapy/Radiation
18 Magnolol
17 Phenethyl isothiocyanate
16 Baicalein
16 Emodin
15 Artemisinin
15 Capsaicin
15 Piperlongumine
14 Magnetic Fields
14 Luteolin
14 Shikonin
13 Cisplatin
13 doxorubicin
13 EGCG (Epigallocatechin Gallate)
13 Chrysin
13 Garcinol
13 Lycopene
13 Resveratrol
12 Ashwagandha(Withaferin A)
12 Betulinic acid
12 Eugenol
12 Cucurbitacin
12 Honokiol
12 Licorice
11 Graviola
11 Licochalcone A
11 Linalool
10 Propolis -bee glue
9 5-fluorouracil
9 Rosmarinic acid
9 Ellagic acid
9 Formononetin
9 phytic acid, Inositol hexakisphosphate
9 Ivermectin
9 mebendazole
9 Silymarin (Milk Thistle) silibinin
9 Urolithin
8 Allicin (mainly Garlic)
8 Carvacrol
8 Crocetin
8 Diindolylmethane
8 Indole-3-carbinol
8 Ferulic acid
8 Paclitaxel/Taxol
8 Gallic acid
8 Ginkgetin
8 HydroxyTyrosol
7 Chemotherapy
7 Melatonin
7 chitosan
7 Evodiamine
7 Fucoidan
7 Juglone
7 Phenylbutyrate
7 Pterostilbene
6 Astaxanthin
6 Berbamine
6 Boswellia (frankincense)
6 Celastrol
6 chaetocin
6 Gambogic Acid
6 itraconazole
6 Matrine
6 Morin
6 Naringin
6 Selenite (Sodium)
5 Coenzyme Q10
5 Beta-Caryophyllene
5 Bufalin/Huachansu
5 Boron
5 Caffeic Acid Phenethyl Ester (CAPE)
5 Centella asiatica / Gotu kola → asiaticoside
5 Chlorogenic acid
5 Carvone
5 Cynaropicrin
5 Dandelion Root
5 Eurycomanone
5 Fenbendazole
5 Genistein (soy isoflavone)
5 isoorientin
5 Laetrile B17 Amygdalin
5 lambertianic acid
5 methylseleninic acid
5 Methylsulfonylmethane
5 Nimbolide
5 Plumbagin
5 salinomycin
5 Ursolic acid
5 Vitamin K2
4 1,8-Cineole
4 Vitamin C (Ascorbic Acid)
4 D-limonene
4 Brucea javanica
4 Caffeic acid
4 Thymol-Thymus vulgaris
4 Selenium
4 Cinnamon
4 Hydroxycinnamic-acid
4 Deguelin
4 Hyperoside
4 Lemongrass Extract/Citral
4 Methyl Jasmonate
4 Magnetic Field Rotating
4 Moringa oleifera
4 Marjoram (Origanum majorana)
4 VitK3,menadione
4 α-Santalol/Sandalwood oil
4 Selenium NanoParticles
4 Aflavin-3,3′-digallate
3 Astragalus
3 Copper and Cu NanoParticles
3 Alpha-Lipoic-Acid
3 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
3 Andrographis
3 Gemcitabine (Gemzar)
3 Anethole/trans-Anethole
3 Fennel Oil/Foeniculum vulgare
3 Isovitexin
3 Biochanin A
3 borneol
3 Bruteridin(bergamot juice)
3 Carnosic acid
3 Celecoxib
3 Cynara scolymus/Globe Artichoke/Artichoke Extract
3 Date Fruit Extract
3 diet Methionine-Restricted Diet
3 Piperine
3 Flaxseed/Linseed
3 SDG/lignans
3 Ginger/6-Shogaol/Gingerol
3 Hibiscus sabdariffa
3 Hyperthermia
3 Inositol
3 Isoliquiritigenin
3 Lasiodin
3 Metformin
3 Magnesium
3 Propyl gallate
3 Parthenolide
2 Gold NanoParticles
2 Photodynamic Therapy
2 Glucose
2 tamoxifen
2 DTS(dibenzyl trisulphide) from Anamu
2 Ascorbyl Palmitate
2 Atorvastatin
2 beta-glucans
2 Baicalin
2 Bacopa monnieri
2 α-Bisabolol / Chamomile oil
2 Butyrate
2 Zinc
2 NTP, Non-Thermal Plasma,Cold Atmospheric Plasma
2 Chlorophyllin
2 Docetaxel
2 Dihydrocaffeic Acid
2 Cyclopamine
2 Dichloroacetate
2 Diclofenac
2 Echinacea
2 Electrical Pulses
2 Flaxseed Oil
2 carboplatin
2 Geraniol
2 isoflavones
2 isoquercitrin
2 Vitexin
2 Lactoferrin/Talactoferrin
2 Lutein
2 Methylene blue
2 Modified Citrus Pectin
2 Lemon Balm/Melissa officinalis
2 Mucuna pruriens/Velvet Bean
2 Mistletoe/Viscum album Extracts
2 Mushroom Chaga, Inonotus obliquus
2 Mushroom Lion’s Mane, Hericium erinaceus
2 Oleuropein
2 Rauwolfia serpentina/Indian Snakeroot
2 Rutin
2 Terpinen-4-ol / Tea Tree Oil
1 3-bromopyruvate
1 Ajoene (compound of Garlic)
1 alpha Linolenic acid
1 Arctigenin
1 Aloe anthraquinones
1 immunotherapy
1 epirubicin
1 brusatol
1 Bromelain
1 Carnosine
1 Selenate
1 Chocolate
1 Vitamin E
1 Polyphenols
1 Docosahexaenoic Acid
1 diet FMD Fasting Mimicking Diet
1 Dipyridamole
1 Disulfiram
1 Cannabichromene
1 Citric Acid
1 Sorafenib (brand name Nexavar)
1 flavonoids
1 Arsenic trioxide
1 Vitamin A, Retinoic Acid
1 Shilajit/Fulvic Acid
1 Galloflavin
1 Ginkgolic acids
1 Ginkgo biloba
1 Germanium inorganic
1 Ginkgolide B
1 Ginseng
1 HydroxyCitric Acid
1 Rapamycin
1 High-Ozonide Oil
1 Isobavachalcone
1 iodine
1 Inulin Prebiotic
1 Recombinant Methioninase
1 Lactobacillus
1 Lapachol
1 low dose naltrexone
1 Mung Bean Sprouts
1 Dordaviprone; Modeyso
1 MCT, metronomic chemo
1 Methylglyoxal
1 Myricetin
1 Niclosamide (Niclocide)
1 Proanthocyanidins
1 Purple Corn / Purple Maize
1 Sanguinarine
1 Psoralidin
1 Rhein
1 buckwheat sprouts
1 Oxaliplatin
1 Sulfasalazine
1 Auranofin
1 Salvia miltiorrhiza
1 Spermidine
1 Osimertinib
1 Adagrasib
1 Turmerones
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:322  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

Home Page