toxicity Cancer Research Results

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Toxicity
Scientific Papers found: Click to Expand⟱
3296- SIL,    Silibinin induces oral cancer cell apoptosis and reactive oxygen species generation by activating the JNK/c-Jun pathway
- in-vitro, Oral, Ca9-22 - in-vivo, Oral, YD10B
TumCP↓, TumCCA↑, ROS↑, SOD1↓, SOD2↓, *JNK↑, toxicity?, TumCMig↓, TumCI↓, N-cadherin↓, Vim↓, E-cadherin↑, EMT↓, P53↑, cl‑Casp3↑, cl‑PARP↑, BAX↑, Bcl-2↓, SOD↓,
3290- SIL,    A review of therapeutic potentials of milk thistle (Silybum marianum L.) and its main constituent, silymarin, on cancer, and their related patents
- Analysis, Var, NA
hepatoP↑, chemoP↑, *lipid-P↓, *antiOx↑, tumCV↓, TumCMig↓, Apoptosis↑, ROS↑, GSH↓, Bcl-2↓, survivin↓, cycD1/CCND1↓, NOTCH1↓, BAX↑, NF-kB↓, COX2/PTGS2↓, LOX1↓, iNOS↓, TNF-α↓, IL1↓, Inflam↓, *toxicity↓, CXCR4↓, EGFR↓, ERK↓, MMP↓, Cyt‑c↑, TumCCA↑, RB1↑, P53↑, P21↑, p27/CDKN1B↑, cycE/CCNE↓, CDK4↓, p‑pRB↓, Hif1a↓, cMyc↓, IL1β↓, IFN-γ↓, PCNA↓, PSA↓, CYP1A1↓,
3282- SIL,    Role of Silymarin in Cancer Treatment: Facts, Hypotheses, and Questions
- Review, NA, NA
hepatoP↑, AntiCan↑, TumCMig↓, Hif1a↓, selectivity↑, toxicity∅, *antiOx↑, *Inflam↓, TumCCA↑, P21↑, CDK4↓, NF-kB↓, ERK↓, PSA↓, TumCG↓, p27/CDKN1B↑, COX2/PTGS2↓, IL1↓, VEGF↓, IGFBP3↑, AR↓, STAT3↓, Telomerase↓, Cyt‑c↑, Casp↑, eff↝, HDAC↓, HATs↑, Zeb1↓, E-cadherin↑, miR-203↑, NHE1↓, MMP2↓, MMP9↓, PGE2↓, Vim↓, Wnt↓, angioG↓, VEGF↓, *TIMP1↓, EMT↓, TGF-β↓, CD44↓, EGFR↓, PDGF↓, *IL8↓, SREBP1/SREBF1↓, MMP↓, ATP↓, uPA↓, PD-L1↓, NOTCH↓, *SIRT1↑, SIRT1↓, CA↓, Ca+2↑, chemoP↑, cardioP↑, Dose↝, Half-Life↝, BioAv↓, BioAv↓, BioAv↓, toxicity↝, Half-Life↓, ROS↓, FAK↓,
2233- SK,    Clinical trial on the effects of shikonin mixture on later stage lung cancer
- Trial, Lung, NA
TumVol↓, Remission↑, OS↑, QoL↑, Weight↑, *toxicity∅,
977- SK,    A novel antiestrogen agent Shikonin inhibits estrogen-dependent gene transcription in human breast cancer cells
- in-vitro, BC, T47D - in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF7 - in-vitro, Nor, HMEC
TumCG↓, ERα/ESR1↓, selectivity↑, *toxicity↓,
2009- SK,    Necroptosis inhibits autophagy by regulating the formation of RIP3/p62/Keap1 complex in shikonin-induced ROS dependent cell death of human bladder cancer
- in-vitro, Bladder, NA
TumCG↓, selectivity↑, *toxicity∅, Necroptosis↑, ROS↑, p62↑, Keap1↑, *NRF2↑, eff↑,
2008- SK,  Cisplatin,    Enhancement of cisplatin-induced colon cancer cells apoptosis by shikonin, a natural inducer of ROS in vitro and in vivo
- in-vitro, CRC, HCT116 - in-vivo, NA, NA
ChemoSen↑, selectivity↑, i-ROS↑, DNAdam↑, MMP↓, TumCCA↑, eff↓, *toxicity↓,
2007- SK,    Shikonin Directly Targets Mitochondria and Causes Mitochondrial Dysfunction in Cancer Cells
- in-vitro, lymphoma, U937 - in-vitro, BC, MCF7 - in-vitro, BC, SkBr3 - in-vitro, CRC, HCT116 - in-vitro, OS, U2OS - NA, Nor, RPE-1
tumCV↓, selectivity↑, Dose↝, other↑, MMP↓, ROS↑, DNAdam↑, Ca+2↑, Casp9↑, Cyt‑c↑, *toxicity↓,
1706- SSE,    Selenium in Prostate Cancer: Prevention, Progression, and Treatment
- Review, Pca, NA
Risk∅, ChemoSen↑, Risk↓, toxicity↝, Risk↑, eff↑, *toxicity↑, RadioS↑, eff↓, eff↑, ChemoSen↑, ChemoSideEff↓,
4748- SSE,  Chemo,  antiOx,    Efficacy and safety of intravenous administration of high-dose selenium for preventing chemotherapy-induced peripheral neuropathy in gastric cancer patients receiving adjuvant oxaliplatin and capecitabine after gastrectomy: a retrospective pilot study
- Trial, GC, NA
toxicity↓, chemoP∅, *neuroP↑, *Dose↝,
4740- SSE,    Optimising Selenium for Modulation of Cancer Treatments
- Review, Var, NA
*selenoP↑, *Dose↓, Risk↓, *toxicity↝, Dose↑, chemoP↑, radioP↑,
5076- SSE,    Sodium selenite inhibits the growth of cervical cancer cells through the PI3K/AKT pathway
- in-vivo, Cerv, HeLa - in-vivo, Cerv, SiHa
TumCG↓, toxicity↓, tumCV↓, Apoptosis↑, p‑PI3K↓, p‑Akt↓, eff↑,
5074- SSE,    Application of Sodium Selenite in the Prevention and Treatment of Cancers
- Review, Var, NA
Imm↑, angioG↑, DNArepair↑, NK cell↑, ROS↑, AntiCan↑, selectivity↑, ER Stress↑, TumAuto↑, necrosis↑, toxicity↝, Dose↑,
5073- SSE,    Pharmacokinetics and Toxicity of Sodium Selenite in the Treatment of Patients with Carcinoma in a Phase I Clinical Trial: The SECAR Study
- Trial, Var, NA
AntiTum↑, ChemoSen↑, Dose↑, Half-Life↝, toxicity↝, toxicity↝,
5095- SSE,    Extracellular thiol-assisted selenium uptake dependent on the xc− cystine transporter explains the cancer-specific cytotoxicity of selenite
- in-vitro, Lung, H157
toxicity↝, eff↓, other↝, ROS↑, mtDam↑,
5082- SSE,    Rationale for the treatment of cancer with sodium selenite
- Review, Var, NA
Risk↑, antiOx↑, ROS↑, Imm↑, NK cell↑, angioG↓, toxicity↓,
5085- SSE,    Intravenous Infusion of High Dose Selenite in End-Stage Cancer Patients: Analysis of Systemic Exposure to Selenite and Seleno-Metabolites
- Review, Var, NA
toxicity↝, Half-Life↝, ROS↑, Thiols↓, NADPH↓, toxicity↝, other↝,
4614- SSE,  Rad,    Updates on clinical studies of selenium supplementation in radiotherapy
- Review, Nor, NA
*toxicity∅, Risk↓, *selenoP↑, *ROS↓, *DNAdam↓, *QoL↑, *radioP↑, *Dose↝,
6439- T4O,    Efficacy and safety of Melaleuca alternifolia (tea tree) oil for human health-A systematic review of randomized controlled trials
- Review, Nor, NA
*BioAv↝, *toxicity↝, *BloodF↑, *Sleep↑,
6768- T4O,    Melaleuca alternifolia (Tea Tree) Oil: a Review of Antimicrobial and Other Medicinal Properties
- Review, Nor, NA
*AntiBio↑, *other↝, *AntiFungal↑, *Inflam↓, *ROS⇅, *toxicity↑,
3958- Taur,    Evaluation of the neuroprotective effect of taurine in Alzheimer’s disease using functional molecular imaging
- in-vivo, AD, NA
*neuroP↑, *Aβ∅, *cognitive↑, *toxicity↓, *Ca+2↓, *memory↑,
5334- TFdiG,    Theaflavin inhibits the malignant phenotype of human anaplastic thyroid cancer 8305C cells by regulating lipid metabolism via PI3K/AKT signaling
- in-vitro, Thyroid, 8505C
TumCP↓, TumCMig↓, TumCI↓, Apoptosis↑, Casp3↑, Casp8↑, Casp9↑, survivin↓, SREBP1/SREBF1↓, toxicity↑,
6174- TM,    Tetrathiomolybdate-associated copper depletion decreases circulating endothelial progenitor cells in women with breast cancer at high risk of relapse
- Trial, BC, NA
OS↑, toxicity↓, AntiTum↑, Copper↓, angioG↓,
6173- TM,    Treatment of metastatic cancer with tetrathiomolybdate, an anticopper, antiangiogenic agent: Phase I study
- Trial, Var, NA
toxicity↓, eff↑,
962- TQ,    Thymoquinone affects hypoxia-inducible factor-1α expression in pancreatic cancer cells via HSP90 and PI3K/AKT/mTOR pathways
- in-vitro, PC, PANC1 - in-vitro, Nor, hTERT-HPNE - in-vitro, PC, AsPC-1 - in-vitro, PC, Bxpc-3
TumCMig↓, TumCI↓, Apoptosis↑, Hif1a↓, PI3k/Akt/mTOR↓, TumCCA↑, *toxicity↓, *TumCI∅, *TumCMig∅,
2083- TQ,    Thymoquinone inhibits proliferation in gastric cancer via the STAT3 pathway in vivo and in vitro
- in-vitro, GC, HGC27 - in-vitro, GC, BGC-823 - in-vitro, GC, SGC-7901 - in-vivo, NA, NA
p‑STAT3↓, JAK2↓, c-Src↓, Bcl-2↓, cycD1/CCND1↓, survivin↓, VEGF↓, Casp3?, Casp7?, Casp9?, *toxicity∅, TumVol↓,
2093- TQ,    Regulation of NF-κB Expression by Thymoquinone; A Role in Regulating Pro-Inflammatory Cytokines and Programmed Cell Death in Hepatic Cancer Cells
- in-vitro, Liver, HepG2 - in-vitro, Nor, NA
TumCD↑, selectivity↑, Casp3↑, DLC1↑, NF-kB↑, LDH↑, *toxicity↓,
3421- TQ,    Insights into the molecular interactions of thymoquinone with histone deacetylase: evaluation of the therapeutic intervention potential against breast cancer
- Analysis, Nor, NA - in-vivo, Nor, NA - in-vitro, BC, MCF7 - in-vitro, Nor, HaCaT
HDAC↓, P21↑, Maspin↑, BAX↑, B2M↓, TumCCA↑, selectivity↑, *toxicity↓, TumCMig↓, TumCP↓,
6453- TUR,    Pharmacological Profile, Bioactivities, and Safety of Turmeric Oil
- Review, Var, NA - Review, AD, NA - Review, Park, NA
*Dose↝, *BioEnh↑, *BBB↑, *ROS↓, *GSH↑, *SOD↑, *GSR↑, *NO↓, *P450↓, OS↑, TumCG↓, *GutMicro↑, *Pain↓, *neuroP↑, *AChE↓, *BDNF↑, *Bacteria↓, *AntiFungal↑, *toxicity↓,
5934- TV,    Protective Effects of Natural Antioxidants on Inflammatory Bowel Disease: Thymol and Its Pharmacological Properties
- Review, Var, NA
*Inflam↓, *antiOx↑, *Bacteria↓, AntiTum↑, *toxicity∅, *IBI↑, *ZO-1↑, *OCLN↑, *COX1↑, *TLR4↓, *NF-kB↓, *TNF-α↓, *IL1β↓, *TAC↑, *NRF2↑, *GutMicro↑,
4864- Uro,    Therapeutic Potential of Mitophagy-Inducing Microflora Metabolite, Urolithin A for Alzheimer's Disease
- Review, AD, NA
*neuroP↑, *Half-Life↝, *BBB↑, *toxicity↓, *Inflam↓, *Strength↑, *BACE/β-secretase↓, *Aβ↓, *MitoP↑, *SIRT1↑, *SIRT3↑, *AMPK↑, *PGC-1α↑, *mTOR↓, *PARK2↑, *Beclin-1↑, *ROS↓, *GutMicro↑, *Risk↓,
4861- Uro,    Urolithin A improves Alzheimer's disease cognition and restores mitophagy and lysosomal functions
- in-vivo, AD, NA
*memory↑, *Aβ↓, *toxicity↓, *BBB↑, *p‑tau↓, *eff↓, *IL1α↓, *MCP1/CCL2↓, *MIP‑1α/CCL3↓, *TNF-α↓, *IL2↓, *SIRT1↓, *DNAdam↓, *Dose↝, *Strength↑, *motorD↑, *CTSZ↓,
4837- Uro,    Urolithins: The Gut Based Polyphenol Metabolites of Ellagitannins in Cancer Prevention, a Review
- Review, Var, NA
AntiCan↑, TumCCA↑, Apoptosis↑, TumAuto↑, *BioAv↝, *BioAv↑, RAS↓, ERK↓, AR↓, TumCP↓, PI3K↓, Akt↓, NF-kB↓, COX2/PTGS2↓, IL6↓, IL1β↓, Wnt↓, β-catenin/ZEB1↓, cMyc↓, P53↑, Casp3↑, PARP↑, ROS↓, toxicity↓,
4840- Uro,    Urolithin A: A promising selective estrogen receptor modulator and 27-hydroxycholesterol attenuator in breast cancer
- vitro+vivo, BC, NA
MMP↓, TumCP↓, Apoptosis↑, tumCV↓, ER-α36↝, *toxicity↓,
4853- Uro,    Urolithin A, a novel natural compound to target PI3K/AKT/mTOR pathway in pancreatic cancer
- vitro+vivo, PC, MIA PaCa-2 - in-vitro, NA, PANC1
p‑Akt↓, p‑p70S6↓, TumCG↓, OS↑, PI3K↓, mTOR↓, TumCP↓, TumCMig↓, Apoptosis↑, TAMS↓, Treg lymp↓, Wnt↓, IGF-1↓, *toxicity↓, *BioAv↑, Half-Life↝,
1888- VitB1/Thiamine,  DCA,    High Dose Vitamin B1 Reduces Proliferation in Cancer Cell Lines Analogous to Dichloroacetate
- in-vitro, PC, SK-N-BE - NA, PC, PANC1
p‑PDH↓, GlucoseCon↓, lactateProd↓, MMP↓, Casp3↑, eff↑, PDKs↓, selectivity↑, TumCG↓, Dose∅, MMP↓, ROS∅, toxicity↑, antiOx↑,
610- VitC,    Pharmacologic ascorbic acid concentrations selectively kill cancer cells: Action as a pro-drug to deliver hydrogen peroxide to tissues
- in-vitro, lymphoma, JPL119 - in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231 - in-vitro, BC, HS587T - in-vitro, Nor, NA
Apoptosis↑, necrosis↑, H2O2↑, *toxicity↓,
2283- VitK2,    Vitamin K Contribution to DNA Damage—Advantage or Disadvantage? A Human Health Response
- Review, Var, NA
*ER Stress↓, *toxicity↓, *toxicity↑, ROS↑, PI3K↑, Akt↑, Hif1a↑, GlucoseCon↑, lactateProd↑, ChemoSen↑, eff↑, eff↑,
2279- VitK2,    Vitamin K2 Induces Mitochondria-Related Apoptosis in Human Bladder Cancer Cells via ROS and JNK/p38 MAPK Signal Pathways
- in-vitro, Bladder, T24/HTB-9 - in-vitro, Bladder, J82 - in-vitro, Nor, HEK293 - in-vitro, Nor, L02 - in-vivo, NA, NA
MMP↓, Cyt‑c↑, Casp3↑, p‑JNK↑, p‑p38↑, ROS↑, eff↓, tumCV↓, selectivity↑, *toxicity↓, TumVol↓,
1817- VitK2,    Research progress on the anticancer effects of vitamin K2
- Review, Var, NA
TumCCA↑, Apoptosis↑, TumAuto↑, TumCI↓, TumCG↓, ChemoSen↓, ChemoSideEff↓, toxicity∅, eff↑, cycD1/CCND1↓, CDK4↓, eff↑, IKKα↓, NF-kB↓, other↑, p27/CDKN1B↑, cMyc↓, i-ROS↑, Bcl-2↓, BAX↑, p38↑, MMP↓, Casp9↑, p‑ERK↓, RAS↓, MAPK↓, p‑P53↑, Casp8↑, Casp3↑, cJun↑, MMPs↓, eff↑, eff↑,
1824- VitK2,    Vitamin K and its analogs: Potential avenues for prostate cancer management
- Review, Pca, NA
AntiCan↑, toxicity∅, Risk↓, Apoptosis↑, ROS↑, TumCCA↑, eff↑, DNAdam↑, MMP↓, Cyt‑c↑, pro‑Casp3↑, FasL↑, Fas↑, TumAuto↑, ChemoSen↑, RadioS↑,
1818- VitK2,    New insights on vitamin K biology with relevance to cancer
- Review, Var, NA
TumCG↓, ChemoSen↑, toxicity∅, OS↑, BMD↑, eff↑, MMP↓, ROS↑, eff↓, ERK↑, JNK↑, p38↑, Cyt‑c↑, Casp↑, ATP↓, lactateProd↑, AMPK↑, Rho↓, TumCG↓, BioAv↑, cardioP↑, Risk↓,
7905- VT,    Vitexin induces apoptosis and enhances daunorubicin efficacy in acute leukemia via modulation of the HIF-1α/Bcl-2/caspase-3 pathway
- in-vitro, AML, APL NB4
tumCV↓, toxicity↓, selectivity↑, Apoptosis↑, Hif1a↓, Casp3↑, eff↑,
1754- WBV,    Vibration Therapy for Cancer-Related Bone Diseases
- Review, Var, NA
*BMD↑, *toxicity∅, other↓, Dose↝, Dose↑, eff↑, eff↑, eff↑,
1752- WBV,  Chemo,    Feasibility of whole body vibration during intensive chemotherapy in patients with hematological malignancies – a randomized controlled pilot study
- Trial, Var, NA
*BP∅, eff↑, Dose∅, other↑, *toxicity∅, eff↑,
2427- Wog,    Anti-cancer natural products isolated from chinese medicinal herbs
- Review, Var, NA
NO↓, PGE2↓, COX2/PTGS2↓, Ca+2↑, mtDam↑, *toxicity↓, eff↑, eff↓,
1913- Xyl,    Partial Substitution of Glucose with Xylitol Prolongs Survival and Suppresses Cell Proliferation and Glycolysis of Mice Bearing Orthotopic Xenograft of Oral Cancer
- in-vivo, Oral, NA
TumVol↓, OS↑, PFK↓, toxicity↓, Dose∅, Ki-67↓,
4889- ZER,    Zerumbone reduces proliferation of HCT116 colon cancer cells by inhibition of TNF-alpha
- in-vitro, CRC, HCT116
TumCP↓, TNF-α↓, *toxicity↝,

Showing Research Papers: 651 to 698 of 698
Prev Page 14 of 14

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 698

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 2,   Copper↓, 1,   CYP1A1↓, 1,   GSH↓, 1,   H2O2↑, 1,   Keap1↑, 1,   ROS↓, 2,   ROS↑, 12,   ROS∅, 1,   i-ROS↑, 2,   SOD↓, 1,   SOD1↓, 1,   SOD2↓, 1,   Thiols↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↓, 2,   MMP↓, 11,   mtDam↑, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 1,   cMyc↓, 3,   GlucoseCon↓, 1,   GlucoseCon↑, 1,   lactateProd↓, 1,   lactateProd↑, 2,   LDH↑, 1,   NADPH↓, 1,   p‑PDH↓, 1,   PDKs↓, 1,   PFK↓, 1,   PI3k/Akt/mTOR↓, 1,   SIRT1↓, 1,   SREBP1/SREBF1↓, 2,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,   Akt↑, 1,   p‑Akt↓, 2,   Apoptosis↑, 11,   BAX↑, 4,   Bcl-2↓, 4,   Casp↑, 2,   Casp3?, 1,   Casp3↑, 7,   cl‑Casp3↑, 1,   pro‑Casp3↑, 1,   Casp7?, 1,   Casp8↑, 2,   Casp9?, 1,   Casp9↑, 3,   Cyt‑c↑, 6,   Fas↑, 1,   FasL↑, 1,   iNOS↓, 1,   JNK↑, 1,   p‑JNK↑, 1,   MAPK↓, 1,   Necroptosis↑, 1,   necrosis↑, 2,   p27/CDKN1B↑, 3,   p38↑, 2,   p‑p38↑, 1,   survivin↓, 3,   Telomerase↓, 1,   TumCD↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

p‑p70S6↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

cJun↑, 1,   HATs↑, 1,   other↓, 1,   other↑, 3,   other↝, 2,   p‑pRB↓, 1,   tumCV↓, 6,  

Protein Folding & ER Stress(tgid=8) ⓘ

ER Stress↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

p62↑, 1,   TumAuto↑, 4,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 3,   DNArepair↑, 1,   P53↑, 3,   p‑P53↑, 1,   PARP↑, 1,   cl‑PARP↑, 1,   PCNA↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK4↓, 3,   cycD1/CCND1↓, 3,   cycE/CCNE↓, 1,   P21↑, 3,   RB1↑, 1,   TumCCA↑, 9,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CD44↓, 1,   EMT↓, 2,   ERK↓, 3,   ERK↑, 1,   p‑ERK↓, 1,   HDAC↓, 2,   IGF-1↓, 1,   IGFBP3↑, 1,   mTOR↓, 1,   NOTCH↓, 1,   NOTCH1↓, 1,   PI3K↓, 2,   PI3K↑, 1,   p‑PI3K↓, 1,   RAS↓, 2,   c-Src↓, 1,   STAT3↓, 1,   p‑STAT3↓, 1,   TumCG↓, 10,   Wnt↓, 3,  

Migration(tgid=13) ⓘ

CA↓, 1,   Ca+2↑, 3,   DLC1↑, 1,   E-cadherin↑, 2,   ER-α36↝, 1,   FAK↓, 1,   Ki-67↓, 1,   miR-203↑, 1,   MMP2↓, 1,   MMP9↓, 1,   MMPs↓, 1,   N-cadherin↓, 1,   PDGF↓, 1,   Rho↓, 1,   TGF-β↓, 1,   Treg lymp↓, 1,   TumCI↓, 4,   TumCMig↓, 7,   TumCP↓, 7,   uPA↓, 1,   Vim↓, 2,   Zeb1↓, 1,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 3,   angioG↑, 1,   EGFR↓, 2,   Hif1a↓, 4,   Hif1a↑, 1,   LOX1↓, 1,   NO↓, 1,   TAMS↓, 1,   VEGF↓, 3,  

Barriers & Transport(tgid=15) ⓘ

NHE1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

B2M↓, 1,   COX2/PTGS2↓, 4,   CXCR4↓, 1,   IFN-γ↓, 1,   IKKα↓, 1,   IL1↓, 2,   IL1β↓, 2,   IL6↓, 1,   Imm↑, 2,   Inflam↓, 1,   JAK2↓, 1,   NF-kB↓, 4,   NF-kB↑, 1,   NK cell↑, 2,   PD-L1↓, 1,   PGE2↓, 2,   PSA↓, 2,   TNF-α↓, 2,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 2,   ERα/ESR1↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 3,   BioAv↑, 1,   ChemoSen↓, 1,   ChemoSen↑, 7,   Dose↑, 4,   Dose↝, 3,   Dose∅, 3,   eff↓, 6,   eff↑, 21,   eff↝, 1,   Half-Life↓, 1,   Half-Life↝, 4,   RadioS↑, 2,   selectivity↑, 11,  

Clinical Biomarkers(tgid=22) ⓘ

AR↓, 2,   B2M↓, 1,   BMD↑, 1,   EGFR↓, 2,   ERα/ESR1↓, 1,   IL6↓, 1,   Ki-67↓, 1,   LDH↑, 1,   Maspin↑, 1,   PD-L1↓, 1,   PSA↓, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 4,   AntiTum↑, 3,   cardioP↑, 2,   chemoP↑, 3,   chemoP∅, 1,   ChemoSideEff↓, 2,   hepatoP↑, 2,   OS↑, 6,   QoL↑, 1,   radioP↑, 1,   Remission↑, 1,   Risk↓, 5,   Risk↑, 2,   Risk∅, 1,   toxicity?, 1,   toxicity↓, 8,   toxicity↑, 2,   toxicity↝, 8,   toxicity∅, 4,   TumVol↓, 4,   Weight↑, 1,  
Total Targets: 204

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

AntiBio↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 3,   GSH↑, 1,   GSR↑, 1,   lipid-P↓, 1,   NRF2↑, 2,   PARK2↑, 1,   ROS↓, 3,   ROS⇅, 1,   selenoP↑, 2,   SIRT3↑, 1,   SOD↑, 1,   TAC↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

PGC-1α↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 1,   SIRT1↓, 1,   SIRT1↑, 2,  

Cell Death(tgid=5) ⓘ

JNK↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↝, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ER Stress↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1↑, 1,   MitoP↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 2,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

mTOR↓, 1,  

Migration(tgid=13) ⓘ

Ca+2↓, 1,   TIMP1↓, 1,   TumCI∅, 1,   TumCMig∅, 1,   ZO-1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

NO↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 3,   IBI↑, 1,   OCLN↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX1↑, 1,   CTSZ↓, 1,   IL1α↓, 1,   IL1β↓, 1,   IL2↓, 1,   IL8↓, 1,   Inflam↓, 4,   MCP1/CCL2↓, 1,   MIP‑1α/CCL3↓, 1,   NF-kB↓, 1,   TLR4↓, 1,   TNF-α↓, 2,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 1,   BDNF↑, 1,   p‑tau↓, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 2,   Aβ∅, 1,   BACE/β-secretase↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 2,   BioAv↝, 2,   BioEnh↑, 1,   Dose↓, 1,   Dose↝, 4,   eff↓, 1,   Half-Life↝, 1,   P450↓, 1,  

Clinical Biomarkers(tgid=22) ⓘ

BloodF↑, 1,   BMD↑, 1,   BP∅, 1,   GutMicro↑, 3,  

Functional Outcomes(tgid=23) ⓘ

cognitive↑, 1,   memory↑, 2,   motorD↑, 1,   neuroP↑, 4,   Pain↓, 1,   QoL↑, 1,   radioP↑, 1,   Risk↓, 1,   Sleep↑, 1,   Strength↑, 2,   toxicity↓, 17,   toxicity↑, 3,   toxicity↝, 3,   toxicity∅, 7,  

Infection & Microbiome(tgid=24) ⓘ

AntiFungal↑, 2,   Bacteria↓, 2,  
Total Targets: 79

Scientific Paper Hit Count for: toxicity, toxicity
31 Silver-NanoParticles
21 Selenium NanoParticles
17 chitosan
16 Magnetic Fields
13 Chemotherapy
13 Dichloroacetate
12 Selenite (Sodium)
12 Sulforaphane (mainly Broccoli)
11 5-Hydroxytryptophan
11 Radiotherapy/Radiation
10 3-bromopyruvate
10 Curcumin
10 EGCG (Epigallocatechin Gallate)
10 Hydrogen Gas
9 Honokiol
9 Phenylbutyrate
8 Cisplatin
8 Copper and Cu NanoParticles
8 Ginkgo biloba-EGb 761
8 Fenbendazole
8 itraconazole
7 Ashwagandha(Withaferin A)
7 Baicalein
7 Berberine
7 Carvacrol
7 Dandelion Root
7 Graviola
6 Apigenin (mainly Parsley)
6 borneol
6 Boron
6 Metformin
6 D-limonene
6 Emodin
6 Eugenol
6 Germanium inorganic
6 IP6 (Inositol 1,2,3,4,5,6-hexakisphosphate)
6 Resveratrol
6 Magnetic Field Rotating
6 Piperlongumine
6 Pterostilbene
6 Selenium
5 Auranofin
5 Allicin (mainly Garlic)
5 HydroxyCitric Acid
5 Artemisinin
5 Capsaicin
5 Ellagic acid
5 Hyperthermia
5 Inositol
5 Lactoferrin/Talactoferrin
5 Shikonin
5 Urolithin
5 Vitamin K2
4 Gold NanoParticles
4 Alpha-Lipoic-Acid
4 beta-glucans
4 Betulinic acid
4 α-Bisabolol / Chamomile oil
4 Celastrol
4 Chlorogenic acid
4 chaetocin
4 Chrysin
4 Cucurbitacin
4 salinomycin
4 Deguelin
4 Disulfiram
4 Folic Acid, Vit B9
4 Fucoidan
4 Gambogic Acid
4 Garcinol
4 Ginkgolic acids
4 Ginkgo biloba
4 Germanium Organic/Ge-132 / propagermanium (organogermanium)
4 Ginger/6-Shogaol/Gingerol
4 isoorientin
4 Kaempferol
4 Propolis -bee glue
4 Phenethyl isothiocyanate
4 Silymarin (Milk Thistle) silibinin
4 Thymoquinone
3 Vitamin C (Ascorbic Acid)
3 SonoDynamic Therapy UltraSound
3 Anti-oxidants
3 doxorubicin
3 Atorvastatin
3 Baicalin
3 Beta-Caryophyllene
3 Bullatacin
3 Carnosine
3 Centella asiatica / Gotu kola → asiaticoside
3 Chlorophyllin
3 Cinnamon
3 Diclofenac
3 Docosahexaenoic Acid
3 diet FMD Fasting Mimicking Diet
3 Oxygen, Hyperbaric
3 Ivermectin
3 Gallic acid
3 Geldanamycin
3 Genistein (soy isoflavone)
3 Ginkgetin
3 Gossypol/AT-101
3 HydroxyTyrosol
3 Indole-3-carbinol
3 Isoliquiritigenin
3 Licochalcone A
3 Magnolol
3 Melatonin
3 Bicarbonate(Sodium)
3 Niclosamide (Niclocide)
3 Quercetin
3 Rosmarinic acid
3 Sulfasalazine
2 Astragalus
2 Zinc
2 Ascorbyl Palmitate
2 Paclitaxel/Taxol
2 Arsenic trioxide
2 Aloe anthraquinones
2 Berbamine
2 brusatol
2 Bacopa monnieri
2 Boswellia (frankincense)
2 Thymol-Thymus vulgaris
2 carboplatin
2 Hydroxycinnamic-acid
2 Coenzyme Q10
2 Vitamin E
2 CUSP9
2 Docetaxel
2 Lemongrass Extract/Citral
2 immunotherapy
2 Echinacea
2 Estragole
2 Fennel Oil/Foeniculum vulgare
2 Evodiamine
2 Ferulic acid
2 Flickering Light Stimulation
2 Formononetin
2 Shilajit/Fulvic Acid
2 Gamma-aminobutyric acid
2 Germanium-Spirogermanium
2 Germacranolide sesquiterpene lactone
2 Hibiscus sabdariffa
2 Hyperoside
2 isoflavones
2 isoquercitrin
2 Laetrile B17 Amygdalin
2 Lapatinib
2 Luteolin
2 Lycopene
2 metronomic chemo
2 Propyl gallate
2 Piperine
2 Psoralidin
2 Ramucirumab (CYRAMZA)
2 EMF
2 Terpinen-4-ol / Tea Tree Oil
2 tetrathiomolybdate
2 Whole Body Vibration
1 1,8-Cineole
1 Resiquimod
1 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
1 DTS(dibenzyl trisulphide) from Anamu
1 Andrographis
1 5-Aminolevulinic acid
1 Aspirin
1 Astaxanthin
1 Dipyridamole
1 Biochanin A
1 Bufalin/Huachansu
1 Brucea javanica
1 Bromelain
1 Bruteridin(bergamot juice)
1 Butyrate
1 Carnosic acid
1 Catechins
1 Cat’s Claw
1 Celecoxib
1 Chocolate
1 Cichoric acid / Chicoric acid
1 Citric Acid
1 Carica papaya leaf extract
1 Camptothecin
1 irinotecan
1 Crocetin
1 Cynara scolymus/Globe Artichoke/Artichoke Extract
1 Black phosphorus
1 chemodynamic therapy
1 Cynaropicrin
1 Cysteamine
1 diet Fermented Foods
1 diet Ketogenic
1 diet Methionine-Restricted Diet
1 Protocatechuic acid
1 ferumoxytol
1 Fisetin
1 Auditory Gamma Stimulation / 40 Hz Auditory Stimulation
1 Vitamin D3
1 Ginkgolide B
1 Grapeseed extract
1 hydroxychloroquine
1 Isobavachalcone
1 imatinib
1 Inulin Prebiotic
1 Isovitexin
1 Juglone
1 L-ornithine
1 Trastuzumab
1 Lapachol
1 Lasiodin
1 Linalool
1 MCToil
1 Methyl Jasmonate
1 Methyl salicylate / Sweet Birch oil
1 magnetic nanoparticles
1 Moringa oleifera
1 Mushroom Lion’s Mane
1 nicotinamide adenine dinucleotide
1 Naringin
1 Oleuropein
1 Peppermint
1 5-fluorouracil
1 sericin
1 Sanguinarine
1 Plumbagin
1 probiotics
1 Bifidobacterium
1 benzo(a)pyrene
1 Rauwolfia serpentina/Indian Snakeroot
1 Rutin
1 buckwheat sprouts
1 α-Santalol/Sandalwood oil
1 Date Fruit Extract
1 Taurine
1 Aflavin-3,3′-digallate
1 Turmerones
1 Vitamin B1/Thiamine
1 Vitexin
1 Wogonin
1 Xylitol
1 Zerumbone
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1025  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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