NRF2 Cancer Research Results

NRF2, nuclear factor erythroid 2-related factor 2: Click to Expand ⟱
Source: TCGA
Type: Antiapoptotic
Nrf2 is responsible for regulating an extensive panel of antioxidant enzymes involved in the detoxification and elimination of oxidative stress. Thought of as "Master Regulator" of antioxidant response.
-One way to estimate Nrf2 induction is through the expression of NQO1.
NQO1, the most potent inducer:
SFN 0.2 μM,
quercetin (2.5 μM),
curcumin (2.7 μM),
Silymarin (3.6 μM),
tamoxifen (5.9 μM),
genistein (6.2 μM ),
beta-carotene (7.2μM),
lutein (17 μM),
resveratrol (21 μM),
indol-3-carbinol (50 μM),
chlorophyll (250 μM),
alpha-cryptoxanthin (1.8 mM),
and zeaxanthin (2.2 mM)

1. Raising Nrf2 enhances the cell's antioxidant defenses and ↓ROS. This strategy is used to decrease chemo-radio side effects.
2. Downregulating Nrf2 lowers antioxidant defenses and ↑ROS. In cancer cells this leads to DNA damage, and cell death.
3. However there are some cases where increasing Nrf2 paradoxically causes an increase in ROS (cancer cells). Such as cases of Mitochondial overload, signal crosstalk, reductive stress

-In some cases, Nrf2 is overexpressed in cancer cells, which can lead to the activation of genes involved in cell proliferation, angiogenesis, and metastasis. This can contribute to the development of resistance to chemotherapy and targeted therapies.
-Increased Nrf2 expression: Lung, Breast, Colorectal, Prostrate.
Decreased Nrf2 expression: Skine, Liver, Pancreatic.
-Nrf2 is a cytoprotective transcription factor which demonstrated both a negative effect as well as a positive effect on cancer
- "promotes Nrf2 translocation from the cytoplasm to the nucleus," means facilitates the movement of Nrf2 into the nucleus, thereby enhancing the cell's antioxidant and cytoprotective responses. -Major regulator of Nrf2 activity in cells is the cytosolic inhibitor Keap1.

Nrf2 Inhibitors and Activators
Nrf2 Inhibitors: Brusatol, Luteolin, Trigonelline, VitC, Retinoic acid, Chrysin
Nrf2 Activators: SFN, OPZ EGCG, Resveratrol, DATS, CUR, CDDO, Api
- potent Nrf2 inducers from plants include sulforaphane, curcumin, EGCG, resveratrol, caffeic acid phenethyl ester, wasabi, cafestol and kahweol (coffee), cinnamon, ginger, garlic, lycopene, rosemany

Nrf2 plays dual roles in that it can protect normal tissues against oxidative damage and can act as an oncogenic protein in tumor tissue.
– In healthy tissues, NRF2 activation helps protect cells from oxidative damage and maintains cellular homeostasis.
– In many cancers, constitutive activation of NRF2 (often through mutations in NRF2 itself or loss-of-function mutations in KEAP1) leads to an enhanced antioxidant capacity.
– This upregulation can promote tumor cell survival by enabling cancer cells to thrive under oxidative stress, resist chemotherapeutic agents, and sustain metabolic reprogramming.
– Elevated NRF2 levels have been implicated in promoting tumor growth, metastasis, and resistance to therapy in various malignancies.
– High or sustained NRF2 activity is frequently associated with aggressive tumor phenotypes, poorer prognosis, and decreased overall survival in several cancer types.
– While its activation is essential for protecting normal cells from oxidative stress, aberrant or sustained NRF2 activation in tumor cells can lead to enhanced survival, therapeutic resistance, and tumor progression.

NRF2 inhibitors: (to decrease antioxidant defenses and increase cell death from ROS).
-Brusatol: most cited natural inhibitors of Nrf2.
-Luteolin: luteolin can reduce Nrf2 activity in specific cancer models and may enhance cell sensitivity to chemotherapy. However, luteolin is also known as an antioxidant, and its influence on Nrf2 can sometimes be context dependent.
-Apigenin: certain studies to down‑regulate Nrf2 in cancer cells: Dose and context dependent .
-Oridonin:
-Wogonin: although its effects might be cell‑ and dose‑specific.
- Withaferin A

Scientific Papers found: Click to Expand⟱
2134- TQ,    Modulation of Nrf2/HO1 Pathway by Thymoquinone to Exert Protection Against Diazinon-induced Myocardial Infarction in Rats
- in-vivo, Nor, NA
*ALAT↓, *AST↓, *MDA↓, *ROS↓, *GSSG↓, *GSH↑, *VitE↑, *VitC↑, *NRF2↑, *HO-1↑, *NQO1↑, *SOD↑, *cardioP↑, *GSH/GSSG↑, *GPx↑,
2135- TQ,    Thymoquinone induces heme oxygenase-1 expression in HaCaT cells via Nrf2/ARE activation: Akt and AMPKα as upstream targets
- in-vitro, Nor, HaCaT
*HO-1↑, *NRF2↑, *e-ERK↑, *e-Akt↑, *AMPKα↑, *ROS⇅, *eff↓, *tumCV∅,
2106- TQ,    Cancer: Thymoquinone antioxidant/pro-oxidant effect as potential anticancer remedy
- Review, Var, NA
Apoptosis↑, TumCCA↑, ROS↑, *Catalase↑, *SOD↑, *GR↑, *GSTA1↓, *GPx↑, *H2O2↓, *ROS↓, *lipid-P↓, *HO-1↑, p‑Akt↓, AMPKα↑, NK cell↑, selectivity↑, Dose↝, eff↑, GSH↓, eff↓, P53↑, p‑STAT3↓, PI3K↑, MAPK↑, GSK‐3β↑, ChemoSen↑, RadioS↑, BioAv↓, NRF2↑,
4538- TQ,    NRF2_and_the_Downregulation_of_PD-L1_in_MDA-MB-231_Triple-Negative_Breast_Cancer_Cells">Thymoquinone Anticancer Effects Through the Upregulation of NRF2 and the Downregulation of PD‐L1 in MDA‐MB‐231 Triple‐Negative Breast Cancer Cells
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MDA-MB-468
antiOx↑, H2O2↓, Catalase↑, SOD↑, GSH↑, PRNP↑, NQO1↑, GCLM↑, NRF2↑, PD-L1↓, chemoPv↑, ROS↓,
5024- TQ,    Thymoquinone: A Tie-Breaker in SARS-CoV2-Infected Cancer Patients?
- Review, Covid, NA
*NRF2↑, *NF-kB↓, *Inflam↓, *ROS↓, *HO-1↑, antiOx↑, GSH↑, GSTs↑, GSR↑, SOD1↑, Catalase↑, GPx↑, p62↓, Beclin-1/ATG6↑, Sepsis↓, cardioP↑, hepatoP↑, neuroP↑,
3405- TQ,  doxoR,    Protective effect of thymoquinone against doxorubicin-induced cardiotoxicity and the underlying mechanism
- vitro+vivo, CardioV, NA
*cardioP↑, *NRF2↑, *HO-1↑, *ROS↓, *NQO1↑, *COX2/PTGS2↓, *NOX4↓, *GPx4↑, *FTH1↑, *p‑mTOR↓, *TGF-β↓,
3410- TQ,    Anti-inflammatory effects of thymoquinone and its protective effects against several diseases
- Review, Arthritis, NA
*Inflam↓, *antiOx↑, *COX2/PTGS2↓, *NRF2↑, *HO-1↑, *IL1β↓, *IL6↓, *TNF-α↓, *IFN-γ↓, *PGE2↓, *cardioP↑, *Catalase↑, *SOD↑, *Thiols↑, *neuroP↑, *IL12↓, *MCP1/CCL2↓, *CXCc↓, *ROS↓, *antiAll↑,
3409- TQ,    Thymoquinone therapy remediates elevated brain tissue inflammatory mediators induced by chronic administration of food preservatives
- in-vivo, Nor, NA
*MDA↓, *TGF-β↓, *CRP↓, *NF-kB↓, *TNF-α↓, *IL1β↓, *Casp3↓, *GSH↑, *NRF2↑, *IL10↑, *neuroP↑, *ROS↓, *Apoptosis↓, *Inflam↓,
3406- TQ,  SeNPs,    A study to determine the effect of nano-selenium and thymoquinone on the Nrf2 gene expression in Alzheimer’s disease
- in-vivo, AD, NA
*NRF2↑, *GSH↑, *MDA↓, *TNF-α↓,
3404- TQ,    The Neuroprotective Effects of Thymoquinone: A Review
- Review, Var, NA - Review, AD, NA - Review, Park, NA - Review, Stroke, NA
*Inflam↓, AntiCan↑, *TNF-α↓, *IL6↓, *IL1β↓, *NF-kB↓, *iNOS↓, *NRF2↑, *neuroP↑, *MMP↑, *ROS↓, *MDA↓, *GSH↑, *Catalase↑, *SOD↑, *IL12↓, *MCP1/CCL2↓, *IP-10/CXCL-10↓, *PGE2↓, *antiAll?,
3402- TQ,    Enhanced Apoptosis in Pancreatic Cancer Cells through Thymoquinone-rich Nigella sativa L. Methanol Extract: Targeting NRF2/HO-1 and TNF-α Pathways
- in-vitro, PC, PANC1 - in-vitro, PC, MIA PaCa-2
tumCV↓, NRF2↑, HO-1↑, TNF-α↓,
3401- TQ,    Molecular mechanisms and signaling pathways of black cumin (Nigella sativa) and its active constituent, thymoquinone: a review
- Review, Var, NA
TumCP↓, *antiOx↑, *ROS↓, NRF2↑, NF-kB↓, TumCCA↑, *GABA↑, P53↑, P21↑, AMPK↑, neuroP↑, cardioP↑, hepatoP↑,
3400- TQ,  Chemo,    Thymoquinone Ameliorates Carfilzomib-Induced Renal Impairment by Modulating Oxidative Stress Markers, Inflammatory/Apoptotic Mediators, and Augmenting Nrf2 in Rats
- in-vitro, Nor, NA
*GSH↑, *SOD↑, *lipid-P↓, *IL1β↓, *IL6↓, *TNF-α↓, *Casp3↓, *Catalase↑, *NRF2↑, *RenoP↑,
3399- TQ,    Anticancer Effects of Thymoquinone through the Antioxidant Activity, Upregulation of Nrf2, and Downregulation of PD-L1 in Triple-Negative Breast Cancer Cells
- in-vitro, BC, MDA-MB-231 - NA, BC, MDA-MB-468
ROS↓, H2O2↓, Catalase↑, SOD↑, GSH↑, NQO1↑, GCLM↑, NRF2↑, PD-L1↓, GSSG↑, GPx1⇅, GPx4↓,
3398- TQ,  5-FU,    Impact of thymoquinone on the Nrf2/HO-1 and MAPK/NF-κB axis in mitigating 5-fluorouracil-induced acute kidney injury in vivo
- in-vivo, Nor, NA
*RenoP↑, *TAC↑, *ROS↓, *lipid-P↓, *p38↓, *MAPK↓, *NF-kB↓, *NRF2↑, *HO-1↑, *MDA↓, *GPx↑, *GSR↑, *Catalase↑, *BUN↓, *LDH↓, *IL1β↓,
3415- TQ,    The anti-neoplastic impact of thymoquinone from Nigella sativa on small cell lung cancer: In vitro and in vivo investigations
- in-vitro, Lung, H446
tumCV↓, TumCCA↑, ROS↓, CycB/CCNB1↑, CycD3↑, cycA1/CCNA1↓, cycE/CCNE↓, cDC2↓, antiOx↑, PARP↓, NRF2↓, ARE/EpRE↑, eff↓,
3559- TQ,    Molecular signaling pathway targeted therapeutic potential of thymoquinone in Alzheimer’s disease
- Review, AD, NA - Review, Var, NA
*antiOx↑, *Inflam↓, *AChE↓, AntiCan↑, *cardioP↑, *RenoP↑, *neuroP↑, *hepatoP↑, TumCG↓, Apoptosis↑, PI3K↓, Akt↑, TumCCA↑, angioG↓, *NF-kB↓, *TLR2↓, *TLR4↓, *MyD88↓, *TRIF↓, *IRF3↓, *IL1β↓, *IL6↓, *IL12↓, *NRF2↑, *COX2/PTGS2↓, *VEGF↓, *MMP9↓, *cMyc↓, *cycD1/CCND1↓, *TumCP↓, *TumCI↓, *MDA↓, *TGF-β↓, *CRP↓, *Casp3↓, *GSH↑, *IL10↑, *iNOS↑, *lipid-P↓, *SOD↑, *H2O2↓, *ROS↓, *LDH↓, *Catalase↑, *GPx↑, *AChE↓, *cognitive↑, *MAPK↑, *JNK↑, *BAX↓, *memory↑, *Aβ↓, *MMP↑,
2454- Trip,    Natural product triptolide induces GSDME-mediated pyroptosis in head and neck cancer through suppressing mitochondrial hexokinase-ΙΙ
- in-vitro, HNSCC, HaCaT - in-vivo, NA, NA
GSDME-N↑, Pyro↑, cMyc↓, HK2↓, BAD↑, BAX↑, Casp3↑, NRF2↓, xCT/SLC7A11↓, ROS↑, Synergy↑, Glycolysis↓, GlucoseCon↓, lactateProd↓, ATP↓, xCT/SLC7A11↓, eff↑,
5934- TV,    Protective Effects of Natural Antioxidants on Inflammatory Bowel Disease: Thymol and Its Pharmacological Properties
- Review, Var, NA
*Inflam↓, *antiOx↑, *Bacteria↓, AntiTum↑, *toxicity∅, *IBI↑, *ZO-1↑, *OCLN↑, *COX1↑, *TLR4↓, *NF-kB↓, *TNF-α↓, *IL1β↓, *TAC↑, *NRF2↑, *GutMicro↑,
4869- Uro,    Urolithin A in Central Nervous System Disorders: Therapeutic Applications and Challenges
- Review, AD, NA - Review, Park, NA - Review, Stroke, NA
*MitoP↑, *Inflam↓, *antiOx↑, *Risk↓, *Aβ↓, *p‑tau↓, *p62↓, *PARK2↑, *MMP↑, *ROS↓, *Strength↑, *CRP↓, *IL1β↓, *IL6↓, *TNF-α↓, *AMPK↑, *NF-kB↓, *MAPK↓, *p62↑, *NRF2↑, *SOD↑, *Catalase↑, *HO-1↑, *Ferroptosis↓, *lipid-P↓, *Cartilage↑, *PI3K↓, *Akt↓, *mTOR↓, *Apoptosis↓, *neuroP↑, *Bcl-2↓, *BAX↑, *Casp3↑, *ATP↑, *Synergy↑, *motorD↑, *NLRP3↓, *radioP↑, *BBB↑,
4875- Uro,    Impact of the Natural Compound Urolithin A on Health, Disease, and Aging
- Review, AD, NA - Review, Stroke, NA - Review, ostP, NA - Review, IBD, NA
*MitoP↓, *Strength↑, *PINK1↑, *PARK2↑, *Inflam↓, *COX2/PTGS2↓, *IL1β↓, *IL6↓, *TNF-α↓, *OS↑, *cardioP↑, *memory↑, *neuroG↑, *neuroP↑, *Cartilage↑, *Inflam↓, *RenoP↑, *BioAv↑, *Dose↝, *Half-Life↑, *NRF2↑, *GutMicro↑, *chemoP↑,
4876- Uro,    Urolithin A in Health and Diseases: Prospects for Parkinson’s Disease Management
- Review, Park, NA - Review, AD, NA
*Inflam↓, *antiOx↓, *neuroP↑, *p‑tau↓, *Aβ↓, *Synergy↑, *BioAv↓, *BioAv↑, *GSH↑, *SOD↑, *lipid-P↓, *Catalase↑, *GSR↑, *GPx↑, *ROS↓, *NRF2↑, *GutMicro↑, *Risk↓, *BBB↓, *NLRP3↓, *MAOA↓,
4877- Uro,    Urolithin-A Derivative UAS03 Improves Cognitive Deficits and Memory by Activating Nrf2 Pathways to Alleviate Oxidative Stress and Neuroinflammation
- in-vivo, AD, NA
*cognitive↑, *memory↑, *neuroP↑, *NRF2↑, *ROS↓, *Inflam↓, *IL1β↓, *TNF-α↓, *COX2/PTGS2↓,
7834- VA,  MBS,    Neuroprotective Potential of Mung Bean (Vigna radiata L.) Polyphenols in Alzheimer's Disease: A Review
- Review, AD, NA
*neuroP↑, *memory↑, *Learn↑, *Aβ↓, *BACE/β-secretase↓, *NeuroI↓, *RAGE↓, *antiOx↑, *NRF2↑, *HO-1↑, *GSK‐3β↓, *ROS↓, *AChE↓, *Dose↝,
4311- VitB1/Thiamine,    Benfotiamine treatment activates the Nrf2/ARE pathway and is neuroprotective in a transgenic mouse model of tauopathy
- in-vivo, AD, NA
*Aβ↓, *p‑tau↓, *ROS↓, *cognitive↑, *OS↑, *Mood↑, *neuroP↑, *Inflam↓, *NRF2↑, *PGC-1α↑, *AGEs↓, *4-HNE↓, *NQO1↑, *COX2/PTGS2↓, *TNF-α↓, *IL1β↓, *NF-kB↓, *GSK‐3β↓,
2592- VitC,    Ascorbic acid restores sensitivity to imatinib via suppression of Nrf2-dependent gene expression in the imatinib-resistant cell line
- in-vitro, CLL, NA
NRF2↓, GSH↓,
3108- VitC,  QC,    The role of quercetin and vitamin C in Nrf2-dependent oxidative stress production in breast cancer cells
- in-vitro, BC, MDA-MB-231 - in-vitro, Lung, A549
NRF2↓, HO-1↓, ROS↑, NRF2⇅,
3109- VitC,    Vitamin C Inhibited Pulmonary Metastasis through Activating Nrf2/HO-1 Pathway
- in-vitro, Lung, H1299
TumMeta↓, NRF2↑, HO-1↑, cl‑Casp3↑, cl‑Casp9↑, DNAdam↑, Apoptosis↑, other↑, selectivity↑,
3110- VitC,    Vitamin C Attenuates Oxidative Stress, Inflammation, and Apoptosis Induced by Acute Hypoxia through the Nrf2/Keap1 Signaling Pathway in Gibel Carp (Carassius gibelio)
- in-vivo, Nor, NA
*IL2↑, *IL6↑, *IL12↑, *NRF2↑, *Catalase↑, *SOD↑, *GPx↑, *GRP78/BiP↓, *ER Stress↓,
3112- VitC,    Antioxidative and Anti-Inflammatory Activity of Ascorbic Acid
- Review, Nor, NA
*ROS↓, *antiOx↑, *SOD↑, *Catalase↑, *GPx↑, *NRF2↑, *AP-1↑, *Inflam↓, *CRP↓, IFN-γ↓,
114- VitC,  QC,    Chemoprevention of prostate cancer cells by vitamin C plus quercetin: role of Nrf2 in inducing oxidative stress
- in-vitro, Pca, PC3 - in-vitro, Pca, DU145
GPx↓, GSR↓, NQO1↓, NRF2↓, ROS↑,
1741- VitD3,    Vitamin D Deficiency: Effects on Oxidative Stress, Epigenetics, Gene Regulation, and Aging
- Review, Var, NA
*Inflam↓, *antiOx↑, *eff↑, *ROS↓, *NRF2↑, *GPx↑, *Dose↝, Dose↑,
2276- VitK2,    Vitamin K2 (MK-7) Intercepts Keap-1/Nrf-2/HO-1 Pathway and Hinders Inflammatory/Apoptotic Signaling and Liver Aging in Naturally Aging Rat
- in-vivo, Nor, NA
*ALB↑, *AST↓, *ALAT↓, *Keap1↓, *NRF2↑, *HO-1↑, *COX2/PTGS2↓, *iNOS↓, *TNF-α↓, *TIMP1↓, *TGF-β↓, *ROS↓, *DNAdam↓, *Inflam↓,
7913- VT,    Review of the effects of vitexin in oxidative stress-related diseases
- Review, Nor, NA
*antiOx↑, *ROS↓, *lipid-P↓, *memory↑, *Stroke↓, *cardioP↑, *neuroP↑, *Inflam↓, *NRF2↑, *HO-1↑, *NQO1↑, *GRP78/BiP↑, *CHOP/DDIT3↓, *BACE/β-secretase↓, *ChE↓, *AChE↓, *BChE↓, *GSH↑, *TNF-α↓, *IL1β↓, *IL6↓, *IL33↓, *LDH↓, *MDA↓, *SOD↑,
7902- VT,    Vitexin Protects Against Scopolamine-Induced Cognitive Impairment by Preserving Synaptic Integrity and Modulating Nrf2/HO-1 and NF-κB Signaling Pathways
- in-vivo, AD, NA
*Dose↝, *Learn↑, *memory↑, *AChE↓, *lipid-P↓, *TOS↓, *MDA↓, *ONOO↓, *NO↓, *NOS2↓, *TAC↑, *BDNF↑, *GDNF↑, *PSD95↑, *GFAP↓, *NF-kB↓, *COX2/PTGS2↓, *NRF2↑, *HO-1↑, *neuroP↑, *NeuroI↓,
7887- VT,  IVT,    Dietary Flavonoids Vitexin and Isovitexin: New Insights into Their Functional Roles in Human Health and Disease Prevention
- Review, AD, NA - Review, Var, NA
*antiOx↑, *Inflam↓, *AntiCan↑, *Bacteria↓, *neuroP↑, *Obesity↓, *cardioP↑, *ROS↓, *MMP↑, *ATP↑, *MFN2↑, *DRP1/DNM1L↓, *FOXO3↑, *NRF2↑, *Ferroptosis↓, *GPx4↑, TumCP↓, HMGB1↓, PI3K↓, Akt↓, Hif1a↓, CDK1↓, CycB/CCNB1↓, TumCCA↑, Apoptosis↑, P53↑, NF-kB↓, ERK↓, p‑PI3K↓, miR-34a↑, Apoptosis↑, CSCs?, *MAPK↓, *HO-1↑, *hepatoP↑, *AMPK↑, *Akt↑, *GSK‐3β↑, *chemoP↑, *Casp3↓, *IRes↝, *GlucoseCon↑, ChemoSen↑, *GSH↑, *SOD↑, *ATF2↑, *GPx↑, *GSTs↑, *AntiAge↑, *Stroke↓, *AChE↓, *ACE/ACE1↓, *ACE2↓, *GutMicro↑, *MPO↓, *H+/K+-ATPase↓, *AntiDiabetic↑, *GLUT4↑, *Obesity↓, *HH↓, *RenoP↑, *BioAv↓, *BioAv↝, *BioAv↑,
5015- Xan,  PEITC,    Comparison of the Impact of Xanthohumol and Phenethyl Isothiocyanate and Their Combination on Nrf2 and NF-κB Pathways in HepG2 Cells In Vitro and Tumor Burden In Vivo
- in-vitro, HCC, HepG2
NRF2↓, ROS↑, NF-kB↓, COX2/PTGS2↓, Apoptosis↑, NRF2↑, SOD↑, NQO1↑,

Showing Research Papers: 651 to 687 of 687
Prev Page 14 of 14

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 687

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 6,   antiOx↑, 9,   ARE↓, 1,   ARE↑, 2,   ARE/EpRE↑, 1,   Catalase↓, 13,   Catalase↑, 11,   Copper↑, 1,   Fenton↑, 5,   frataxin↑, 1,   GCLC↑, 2,   GCLM↑, 2,   GPx↓, 4,   GPx↑, 7,   GPx1↓, 2,   GPx1⇅, 1,   GPx4↓, 30,   GSH↓, 47,   GSH↑, 12,   i-GSH↓, 1,   GSH/GSSG↓, 5,   GSR↓, 2,   GSR↑, 3,   GSS↑, 1,   GSSG↑, 3,   GSTs↓, 2,   GSTs↑, 5,   GSTs↝, 1,   H2O2↓, 3,   H2O2↑, 4,   HO-1↓, 33,   HO-1↑, 51,   HO-1⇅, 1,   Iron↓, 1,   Iron↑, 19,   i-Iron↓, 1,   i-Iron↑, 3,   Keap1↓, 6,   Keap1↑, 4,   Keap1↝, 2,   ox-Keap1↓, 1,   rd-Keap1↑, 1,   lipid-P↓, 1,   lipid-P↑, 23,   MDA↓, 5,   MDA↑, 20,   i-MDA↑, 1,   MPO↓, 2,   NADH↓, 1,   NFE2L2↑, 1,   NOX↓, 1,   NOX↑, 1,   NOX4↓, 1,   NOX4↑, 2,   NQO1↓, 8,   NQO1↑, 16,   NRF2↓, 119,   NRF2↑, 129,   NRF2⇅, 4,   NRF2↝, 7,   NRF2∅, 3,   p‑NRF2↓, 2,   p‑NRF2↑, 2,   Prx↓, 1,   Prx↑, 1,   Prx4↑, 1,   PrxI↓, 1,   RNS↓, 1,   ROS?, 2,   ROS↓, 40,   ROS↑, 204,   ROS⇅, 5,   ROS↝, 2,   ROS∅, 2,   i-ROS↑, 1,   mt-ROS↓, 1,   mt-ROS↑, 2,   SAM-e↝, 1,   SOD?, 1,   SOD↓, 11,   SOD↑, 15,   SOD1↓, 1,   SOD1↑, 4,   SOD2↓, 8,   SOD2↑, 3,   T-SOD↓, 1,   Trx↓, 3,   Trx↑, 3,   Trx1↑, 1,   ox-Trx1↑, 1,   TrxR↓, 7,   TrxR↑, 1,   TrxR1↓, 3,   TrxR1↑, 1,   VitC↓, 1,   VitE↓, 1,   xCT/SLC7A11↓, 9,   xCT/SLC7A11↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↑, 1,   FTH1↓, 2,   FTH1↑, 1,   FTL↑, 1,   IronCh↑, 1,   Mets↑, 1,   NCOA4↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

BCR-ABL↓, 1,   CDC2↓, 5,   CDC25↓, 5,   compI↓, 2,   compII↓, 1,   compIII↓, 1,   compIV↓, 1,   EGF↓, 2,   ETC↓, 5,   MFN2↑, 1,   mitResp↓, 2,   MKK7↓, 1,   Mortalin↓, 1,   mtDam↑, 14,   OCR↓, 1,   OCR↑, 1,   OXPHOS↓, 4,   OXPHOS↑, 1,   mt-OXPHOS↓, 1,   PDH↓, 1,   PGC-1α↑, 1,   SDH↓, 1,   SIRT3↓, 2,   SIRT3↑, 3,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 3,   ACC↑, 1,   ACC-α↓, 1,   ACC1↓, 2,   ACLY↓, 2,   ACSL4↑, 2,   ALAT↓, 3,   AMPK↑, 17,   p‑AMPK↑, 1,   p‑AMT/GCST/T-protein↑, 1,   ATP↓, 12,   ATP↑, 1,   mt-ATP↓, 1,   CAIX/CA9↓, 2,   ECAR↓, 1,   ENO1↓, 1,   FASN↓, 5,   G6PD↓, 1,   GLS↓, 1,   glucoNG↓, 1,   glucose↓, 1,   GlucoseCon↓, 7,   GlutMet↓, 2,   Glycolysis↓, 24,   GSK‐3β↓, 8,   GSK‐3β↑, 5,   p‑GSK‐3β↓, 4,   H2S↑, 1,   HK2↓, 13,   lactateProd↓, 6,   lactateProd↑, 1,   LDHA↓, 5,   LDL↓, 1,   MCT4↓, 1,   NAD↓, 1,   NAD↑, 1,   NAD↝, 1,   NADPH↓, 4,   NADPH↑, 6,   PCK1↓, 1,   PDK1 / PDPK1↓, 7,   PDK3↑, 1,   PFK↓, 1,   PKM2↓, 5,   PKM2↑, 1,   PPP↑, 1,   Pyruv↓, 1,   SCD1↓, 2,   SIRT1↓, 3,   SIRT1↑, 6,   SLC1A5↓, 1,   SREBP1/SREBF1↓, 1,   SREBP2↓, 1,   TCA↓, 4,   Warburg↓, 5,  

Cell Death(tgid=5) ⓘ

AIF↑, 5,   APAF1↑, 3,   Apoptosis?, 2,   Apoptosis↓, 3,   Apoptosis↑, 123,   Apoptosis↝, 1,   ASC↓, 1,   ASC↑, 1,   ASK1↑, 1,   p‑ASK1↑, 1,   BAD↑, 3,   Bak↑, 3,   BAX↓, 4,   BAX↑, 63,   BAX↝, 2,   Bax:Bcl2↑, 13,   Bcl-2↓, 61,   Bcl-2↑, 2,   Bcl-2↝, 1,   Bcl-xL↓, 11,   Bcl-xL↝, 1,   BID↑, 4,   BIM↑, 6,   BNIP3↑, 2,   Casp↑, 20,   Casp↝, 1,   cl‑Casp↑, 1,   Casp1↓, 1,   Casp1↑, 1,   cl‑Casp1↑, 1,   Casp10↑, 1,   Casp12?, 1,   Casp12↑, 3,   Casp3↓, 2,   Casp3↑, 66,   Casp3↝, 1,   cl‑Casp3↑, 12,   cl‑Casp3⇅, 1,   proCasp3↑, 3,   Casp7↑, 7,   cl‑Casp7↑, 1,   Casp8↑, 16,   Casp8∅, 2,   cl‑Casp8↑, 1,   proCasp8↑, 1,   Casp9↑, 44,   cl‑Casp9↑, 9,   proCasp9↓, 1,   proCasp9↑, 1,   cFLIP↓, 4,   Cyt‑c↓, 1,   Cyt‑c↑, 55,   Cyt‑c↝, 1,   Diablo↑, 5,   DR5↓, 1,   DR5↑, 20,   Fas↑, 11,   FasL↑, 5,   Ferroptosis↑, 38,   GranB/GZMB↝, 1,   GSDMD↑, 2,   GSDME-N↑, 1,   HEY1↓, 1,   IAP1↓, 4,   IAP1↑, 1,   IAP2/BIRC3↓, 3,   ICAD↑, 1,   iNOS↓, 12,   Mcl-1?, 1,   Mcl-1↓, 8,   Mcl-1↑, 1,   MDM2↓, 8,   p‑MDM2↓, 1,   MOMP↑, 4,   Necroptosis↑, 1,   necrosis↑, 1,   NOXA↑, 1,   p38↓, 5,   p38↑, 11,   p‑p38↓, 2,   p‑p38↑, 3,   Perforin↝, 1,   PUMA↑, 2,   Pyro↑, 4,   RIP3↑, 1,   survivin↓, 27,   TNFR 1↑, 1,   TRAIL↑, 4,   TRAILR↑, 2,   TumCD?, 1,   TumCD↓, 1,   TumCD↑, 8,   XIAP↓, 16,   XIAP↑, 1,   YAP/TEAD↓, 4,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 93,   Akt↑, 3,   Akt↝, 2,   p‑Akt↓, 24,   p‑Akt↑, 1,   AKT1↓, 2,   Akt2↓, 1,   AMPKα↑, 1,   BRAF↝, 1,   p‑CaMKII ↓, 1,   CIP2A↓, 1,   CK2↓, 3,   cMET↓, 2,   p‑cMET↑, 1,   p‑CREB↑, 1,   EF-1α↓, 1,   EGFR↓, 27,   EGFR↑, 1,   EGFR↝, 1,   p‑EGFR↓, 1,   ERK↓, 22,   ERK↑, 6,   p‑ERK↓, 4,   p‑ERK↑, 3,   ERK5↓, 1,   FGFR1↓, 1,   HER2/EBBR2↓, 10,   p‑HER2/EBBR2↓, 1,   HGF/c-Met↓, 2,   Hippo↝, 1,   HRAS↓, 1,   IKKα↓, 5,   IR↓, 1,   IκB↓, 2,   JAK↓, 3,   JAK↝, 1,   JAK1↓, 2,   JAK2↓, 6,   JNK↓, 2,   JNK↑, 14,   JNK↝, 1,   p‑JNK↑, 4,   MAP2K1/MEK1↓, 1,   MAPK↓, 16,   MAPK↑, 17,   MAPK↝, 3,   p‑MAPK↑, 2,   MARK4↓, 1,   p‑MEK↓, 1,   MKK4↓, 1,   mTOR↓, 58,   mTOR↑, 1,   mTOR↝, 3,   p‑mTOR↓, 7,   p‑mTOR↑, 1,   mTORC2↓, 1,   p70S6↓, 2,   P70S6K↓, 4,   P70S6K↑, 1,   p‑P70S6K↓, 1,   P90RSK↓, 1,   PAK↓, 1,   PDGFR-BB↓, 1,   PI3K↓, 73,   PI3K↑, 4,   PI3K↝, 3,   p‑PI3K↓, 6,   p‑PI3K↑, 1,   PI3K/Akt↓, 1,   PI3K/Akt↝, 1,   PKCδ↓, 6,   PKCδ↑, 1,   PTEN↓, 3,   PTEN↑, 15,   PTEN↝, 2,   Raf↓, 2,   c-Raf↓, 1,   RAS↓, 7,   RAS↑, 1,   RET↓, 1,   RIP1↓, 1,   RIP1↑, 1,   SHP1↑, 1,   Sp1/3/4↓, 10,   Src↓, 1,   p‑Src↓, 1,   STAT↓, 2,   STAT3↓, 53,   STAT3↑, 1,   p‑STAT3↓, 6,   STAT4↓, 1,   STAT5↓, 1,   STAT6↓, 1,   p‑STAT6↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF3↑, 2,   ATF4↓, 1,   ATF4↑, 9,   ATF4↝, 1,   ATFs↑, 1,   cJun↓, 4,   cJun↑, 1,   cMyc↓, 24,   p‑cMyc↑, 1,   DNMT1↓, 8,   DNMT3A↓, 4,   DNMT3B↓, 1,   DNMTs↓, 11,   EZH2↓, 1,   FOXM1↓, 2,   FOXO↑, 1,   FOXO1↓, 2,   FOXO1↑, 1,   FOXO3↓, 2,   FOXO3↑, 5,   p‑FOXO3↓, 3,   FOXO4↓, 1,   H3↓, 1,   H3↑, 2,   p‑H3↓, 1,   ac‑H3↓, 1,   ac‑H3↑, 2,   H4↓, 1,   H4↑, 1,   ac‑H4↓, 1,   ac‑H4↑, 2,   HATs↓, 3,   HATs↑, 1,   HDAC↓, 29,   HDAC↑, 1,   HDAC1↓, 6,   HDAC2↓, 6,   HDAC3↓, 6,   HDAC4↓, 1,   HDAC6↓, 1,   HDAC8↓, 3,   HES1↓, 1,   HMTs↓, 1,   KLF4↓, 1,   miR-124-3p↓, 1,   miR-133a-3p↑, 1,   miR-140↑, 1,   miR-155↓, 2,   miR-19b↓, 1,   miR-200c↑, 2,   miR-206↑, 1,   miR-21↓, 1,   miR-21↑, 1,   miR-25-5p↓, 1,   miR-29b↓, 1,   miR-30a-5p↑, 1,   miR-34a↓, 1,   miR-34a↑, 3,   miR-34b-5p↑, 1,   miR-384↑, 1,   miR-590-3p↑, 1,   Myc↓, 2,   OCT4↓, 11,   other?, 1,   other↓, 3,   other↑, 5,   other⇅, 1,   other↝, 9,   PhotoS↑, 1,   RUNX2↓, 1,   SOX2↓, 8,   SOX4↓, 2,   SOX4↑, 1,   SOX9↓, 2,   TET3↑, 1,   tumCV?, 1,   tumCV↓, 32,   USF1↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 4,   CHOP/DDIT3↑, 22,   cl‑CHOP/DDIT3↑, 1,   CUL1↝, 1,   CUL5↝, 1,   eIF2α↓, 1,   eIF2α↑, 5,   p‑eIF2α↑, 4,   ER Stress↑, 37,   GRP78/BiP↑, 9,   GRP94↑, 1,   HSP27↓, 4,   HSP27↑, 1,   HSP27↝, 1,   HSP70/HSPA5↓, 6,   HSP70/HSPA5↑, 2,   HSP70/HSPA5↝, 1,   HSP72↓, 1,   HSP90↓, 11,   ac‑HSP90↑, 1,   HSPs↑, 1,   IRE1↑, 2,   NQO2↑, 1,   PERK↑, 7,   p‑PERK↑, 1,   UPR↑, 10,   XBP-1↓, 2,   XBP-1↑, 2,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 2,   ATG7↑, 1,   Beclin-1/ATG6↓, 4,   Beclin-1/ATG6↑, 9,   CTSB↓, 1,   CTSD↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 2,   LC3A↑, 1,   LC3B-II↑, 2,   LC3II↑, 3,   LC3s↑, 1,   p62↓, 6,   p62↑, 3,   SESN2↑, 1,   TumAuto↓, 1,   TumAuto↑, 20,  

DNA Damage & Repair(tgid=10) ⓘ

ATM?, 1,   ATM↑, 1,   DFF45↓, 1,   DFF45↑, 1,   DNAdam↓, 3,   DNAdam↑, 28,   DNAdam⇅, 1,   DNArepair↓, 1,   m-FAM72A↓, 1,   FEN1↓, 1,   hTERT/TERT↓, 10,   MGMT↓, 1,   P53?, 1,   P53↓, 4,   P53↑, 62,   P53↝, 3,   p‑P53↑, 3,   PARP↓, 4,   PARP↑, 10,   cl‑PARP↓, 2,   cl‑PARP↑, 37,   PARP1↑, 1,   cl‑PARP1↑, 1,   PCNA↓, 18,   POLD1↓, 1,   SIRT6↓, 2,   Telomerase↓, 8,   TOP1↓, 2,   TOP2↓, 3,   γH2AX↑, 2,   p‑γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CC(CDKs/cyclins)↓, 1,   CDK1↓, 14,   CDK1↑, 4,   CDK2↓, 28,   CDK2↑, 2,   CDK4↓, 28,   CDK6↓, 10,   CDK6↑, 1,   CDK8↓, 1,   CHK1↓, 2,   CHK1↑, 1,   Chk2↓, 1,   Chk2↑, 1,   Cyc↓, 3,   Cyc↝, 1,   cycA1/CCNA1↓, 7,   cycA1/CCNA1↑, 1,   CycB/CCNB1↓, 14,   CycB/CCNB1↑, 3,   cycD1/CCND1↓, 40,   cycD1/CCND1↑, 2,   cycD1/CCND1↝, 1,   CycD3↓, 1,   CycD3↑, 1,   cycE/CCNE↓, 12,   cycE/CCNE↑, 2,   Ki-67↓, 15,   mitA↑, 1,   p19↑, 1,   P21?, 1,   P21↓, 4,   P21↑, 44,   P21↝, 1,   p27/CDKN1B↓, 1,   p27/CDKN1B↑, 16,   pRB↓, 1,   p‑pRB↓, 1,   RB1↓, 1,   p‑RB1↓, 5,   Securin↓, 1,   TumCCA?, 1,   TumCCA↓, 2,   TumCCA↑, 112,   WEE1↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

p‑4E-BP1↓, 1,   ALDH↓, 2,   ALDH1A1↓, 2,   BMI1↓, 2,   BMP7/OP1↓, 1,   BMPs↑, 3,   CD133↓, 4,   CD133↑, 1,   CD34↓, 1,   cFos↓, 4,   cFos↑, 1,   cMYB↓, 2,   CSCs?, 1,   CSCs↓, 25,   Diff↑, 2,   EP4/PTGER4↑, 1,   FGF↓, 2,   Gli↓, 2,   Gli1↓, 4,   HH↓, 3,   IGF-1?, 1,   IGF-1↓, 6,   IGFBP3↑, 1,   Ki-67↓, 15,   Let-7↑, 1,   mTORC1↓, 4,   Nanog↓, 10,   Nestin↓, 2,   NICD↓, 1,   NOTCH↓, 10,   NOTCH↑, 1,   NOTCH1↓, 8,   NOTCH1↑, 3,   NOTCH2↑, 1,   NOTCH3↓, 2,   SCF↓, 1,   Shh↓, 5,   Smo↓, 3,   STAT1↓, 3,   TAZ↓, 1,   TumCG↓, 42,   TumCG↑, 1,   TumCP?, 1,   TumCP↓, 88,   TumCP↑, 4,   Wnt↓, 27,   Wnt↝, 1,  

Migration(tgid=13) ⓘ

AEG1↓, 1,   annexin II↓, 1,   AP-1↓, 9,   AP-1↑, 2,   AP-1↝, 1,   ATPase↓, 1,   AXL↓, 1,   BACH1↓, 1,   BACH1↑, 1,   Ca+2↓, 1,   Ca+2↑, 15,   Ca+2↝, 2,   i-Ca+2↑, 1,   CAFs/TAFs↓, 1,   Cal1↑, 1,   cal2↑, 1,   Cdc42↓, 1,   Cofilin↓, 1,   COL1↓, 1,   COL3A1↓, 1,   E-cadherin↓, 4,   E-cadherin↑, 26,   EMT↓, 52,   EMT↝, 1,   FAK↓, 12,   FAK↑, 1,   p‑FAK↓, 2,   Fibronectin↓, 3,   ITGA5↓, 1,   ITGB1↓, 3,   ITGB3↓, 2,   KRAS↓, 2,   LAMs↓, 1,   LEF1↓, 1,   LIMK2↓, 1,   MALAT1↓, 1,   MET↓, 3,   MET↑, 3,   p‑MET↓, 1,   MMP-10↓, 1,   MMP1↓, 5,   MMP13↓, 3,   MMP16↓, 1,   MMP2↓, 45,   MMP2↑, 1,   MMP2⇅, 1,   MMP2↝, 1,   MMP3↓, 7,   MMP7↓, 9,   MMP9↓, 51,   MMP9↑, 2,   MMP9⇅, 1,   MMPs↓, 22,   N-cadherin↓, 20,   NFAT↑, 1,   PDGF↓, 3,   Rac1↓, 1,   Rho↓, 3,   Rho↑, 1,   ROCK1↓, 6,   ROCK1↑, 1,   Slug?, 1,   Slug↓, 7,   Smad1↓, 2,   Smad1↑, 2,   SMAD2↓, 1,   SMAD3↓, 1,   SMAD4↓, 1,   Snail?, 1,   Snail↓, 17,   TET1↓, 1,   TET1↑, 5,   TGF-β↓, 9,   TGF-β↑, 1,   TGF-β1↓, 1,   TIMP1↓, 1,   TIMP1↑, 3,   TIMP2↓, 3,   TIMP2↑, 2,   TRIB3↑, 1,   TSP-1↑, 2,   TumCA↓, 2,   TumCI↓, 54,   TumCMig↓, 47,   TumMeta↓, 37,   TumMeta↑, 3,   TumPF↓, 1,   Twist↓, 13,   TXNIP↑, 1,   Tyro3↓, 1,   uPA↓, 18,   uPAR↓, 1,   Vim?, 1,   Vim↓, 24,   Vim↑, 1,   Zeb1↓, 7,   α-SMA↓, 1,   β-catenin/ZEB1↓, 31,   β-catenin/ZEB1↑, 1,   β-catenin/ZEB1↝, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 56,   CD31/PECAM-1↓, 2,   Endoglin↑, 1,   eNOS↓, 1,   HIF-1↓, 3,   Hif1a↓, 54,   LOX1↓, 1,   NO↓, 4,   NO↑, 1,   REL↑, 1,   VCAM-1↓, 1,   VEGF↓, 73,   VEGF↑, 1,   VEGF↝, 1,   VEGFR1↓, 1,   VEGFR2/KDR/Flk1↓, 11,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 5,   CLDN1↓, 3,   CX43/GJA1↓, 1,   EPR↑, 1,   GLUT1↓, 6,   GLUT4↓, 1,   MMP↓, 60,   MMP↑, 2,   MPT↑, 1,   TRPV1↓, 1,   ZO-1↑, 3,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CB2 / CNR2↑, 1,   CD25+↑, 1,   CD4+↑, 1,   CD44↓, 8,   CD47↓, 1,   CD8+↑, 3,   cDC2↓, 2,   COX1↓, 2,   COX2/PTGS2↓, 45,   COX2/PTGS2↑, 2,   COX2/PTGS2↝, 1,   CXCc↓, 1,   CXCR2↓, 1,   CXCR3↓, 1,   CXCR4↓, 6,   DR4↑, 6,   Eos↑, 1,   FOXP3↑, 2,   Gal-3↓, 1,   HLA-I/II↑, 1,   HMGB1↓, 2,   ICAM-1↓, 8,   IFN-γ↓, 4,   IFN-γ↑, 1,   IL1↓, 6,   IL10↓, 2,   IL10↑, 1,   IL12↓, 2,   IL18↓, 1,   IL1β↓, 13,   IL1β↑, 1,   IL2↓, 3,   IL2↑, 4,   IL4↓, 2,   IL4↑, 1,   IL5↓, 1,   IL6↓, 31,   IL6↑, 1,   IL6↝, 1,   IL8↓, 10,   IL8↑, 1,   Imm↑, 6,   Imm↝, 2,   INF-γ↑, 1,   Inflam↓, 19,   Inflam↑, 1,   M1↓, 1,   M2 MC↓, 2,   pol-M2 MC↓, 1,   MCP1/CCL2↓, 3,   MCT1↓, 1,   NAF1↓, 3,   Neut↑, 1,   NF-kB?, 1,   NF-kB↓, 99,   NF-kB↑, 4,   NF-kB↝, 3,   p‑NF-kB↑, 1,   NK cell↑, 5,   NK cell⇅, 1,   NLRP3↓, 3,   NLRP3↑, 5,   p65↓, 5,   p‑p65↓, 2,   PD-1↓, 3,   PD-L1↓, 9,   PGE2↓, 13,   PSA↓, 7,   PSA↝, 1,   PSA∅, 1,   RAGE↓, 1,   T-Cell↑, 2,   TCF↓, 2,   Th1 response↑, 2,   Th2↑, 1,   TLR1↑, 1,   TLR4↓, 4,   TLR4↝, 1,   TNF-α↓, 23,   TNF-α↑, 1,   TNF-α↝, 1,  

Cellular Microenvironment(tgid=17) ⓘ

GFAP↓, 1,   GGT/CD224↑, 1,   pH↝, 1,   pH∅, 1,   e-pH↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 2,   AChE↓, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,   PRNP↑, 1,   XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACTH↓, 1,   AhR↓, 2,   AhR↓, 1,   AR↓, 8,   AR↝, 1,   COMT↑, 1,   CYP19↓, 1,   ER-α36↓, 4,   ER(estro)↓, 1,   Estro↝, 1,   FGF21↓, 1,   GR↓, 1,   GR↑, 1,   PPARα↓, 1,   PPARγ↓, 3,   PPARγ↑, 4,   SXR↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 1,   BioAv↓, 26,   BioAv↑, 28,   BioAv↝, 9,   BioEnh?, 1,   BioEnh↑, 2,   chemoR↓, 1,   ChemoSen?, 1,   ChemoSen↓, 2,   ChemoSen↑, 118,   ChemoSen⇅, 1,   CYP1A1↓, 3,   CYP1A2↓, 1,   CYP1B1↓, 1,   CYP3A4↓, 2,   Dose?, 1,   Dose↓, 1,   Dose↑, 5,   Dose↝, 26,   Dose∅, 2,   eff↓, 24,   eff↑, 47,   eff↝, 8,   eff∅, 1,   GSTA1↓, 2,   GSTA1↑, 1,   GSTP1/GSTπ↓, 1,   GSTP1/GSTπ↑, 1,   Half-Life↓, 4,   Half-Life↑, 2,   Half-Life↝, 9,   MDR1↓, 6,   MRP1/ABCC1↓, 4,   P-gp/ABCB1↓, 10,   P-gp/ABCB1↑, 1,   P450↓, 3,   P450↝, 1,   RadioS↓, 2,   RadioS↑, 36,   selectivity?, 1,   selectivity↑, 45,   selectivity↝, 1,   selectivity∅, 1,   Synergy↑, 76,   TET2↓, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AFP?, 1,   AFP↓, 1,   ALAT↓, 3,   ALP↓, 2,   AR↓, 8,   AR↝, 1,   AST↓, 2,   BP↓, 1,   BRAF↝, 1,   CEA↓, 1,   CRP↓, 2,   E6↓, 2,   E7↓, 2,   EGFR↓, 27,   EGFR↑, 1,   EGFR↝, 1,   p‑EGFR↓, 1,   EZH2↓, 1,   Ferritin↑, 1,   FOXM1↓, 2,   HER2/EBBR2↓, 10,   p‑HER2/EBBR2↓, 1,   hTERT/TERT↓, 10,   IL6↓, 31,   IL6↑, 1,   IL6↝, 1,   KRAS↓, 2,   LDH↓, 2,   LDH↑, 1,   Myc↓, 2,   NOS2↓, 1,   NSE↓, 1,   PD-L1↓, 9,   PSA↓, 7,   PSA↝, 1,   PSA∅, 1,   PSADT↑, 1,   RAGE↓, 1,   TG/TAG↓, 1,   TRIB3↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiCan?, 1,   AntiCan↓, 1,   AntiCan↑, 30,   AntiCan∅, 2,   antiNeop↑, 2,   AntiTum↑, 18,   Appetite↑, 1,   cachexia↓, 1,   cardioP↑, 7,   CardioT↓, 2,   chemoP↑, 31,   chemoPv↑, 15,   ChemoSideEff↓, 5,   cognitive↑, 3,   fatigue↓, 1,   hepatoP↑, 6,   memory↑, 1,   Mucositis↓, 1,   neuroP↑, 14,   NP/CIPN↓, 2,   OS↓, 1,   OS↑, 8,   Pain↓, 3,   PFS↑, 1,   QoL↑, 5,   radioP↑, 13,   Remission↑, 1,   RenoP↑, 9,   Risk↓, 12,   Risk↑, 1,   Sleep↑, 2,   toxicity↓, 11,   toxicity↑, 2,   toxicity↝, 5,   toxicity∅, 1,   TumVol↓, 8,   TumW↓, 6,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↓, 1,   AntiBio↑, 1,   Bacteria↓, 2,   GutMicro↑, 6,   GutMicro↝, 1,   Sepsis↓, 2,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,   Ingr↝, 3,  
Total Targets: 984

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

NA↓, 1,   NA↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↓, 3,   antiOx?, 1,   antiOx↓, 6,   antiOx↑, 194,   ARE↓, 1,   ARE↑, 15,   ARE↝, 1,   Bil↓, 1,   Bil↑, 2,   Catalase↓, 1,   Catalase↑, 115,   Catalase↝, 1,   DUOX1↓, 1,   Fenton↓, 3,   GCLC↑, 6,   GCLC↝, 1,   GCLM↑, 5,   GCLM↝, 1,   GPx↓, 2,   GPx↑, 82,   GPx↝, 1,   GPx1↑, 3,   GPx4↓, 2,   GPx4↑, 12,   GPx4∅, 1,   GSH↓, 4,   GSH↑, 143,   GSH/GSSG↓, 1,   GSH/GSSG↑, 3,   GSR↓, 2,   GSR↑, 11,   GSS↑, 2,   GSSG↓, 1,   GSTs↓, 4,   GSTs↑, 18,   H2O2↓, 11,   H2O2∅, 1,   HDL↓, 1,   HDL↑, 2,   HNE↓, 1,   HNE↑, 1,   HO-1?, 2,   HO-1↓, 5,   HO-1↑, 208,   HO-1⇅, 1,   HO-1↝, 1,   HO-1∅, 1,   HO-2↓, 1,   hyperG↓, 1,   hyperG↝, 1,   Iron↓, 4,   Iron↝, 1,   i-Iron↓, 3,   Keap1↓, 23,   Keap1↑, 1,   Keap1↝, 2,   ox-Keap1↑, 1,   lipid-P↓, 81,   lipid-P↑, 4,   mt-lipid-P↓, 1,   MDA↓, 120,   MDA↑, 2,   MPO↓, 20,   MPO↑, 1,   NOX↓, 3,   NOX1↓, 1,   NOX2↓, 3,   NOX4↓, 7,   NQO1↑, 56,   NQO1↝, 2,   Nrf1↑, 3,   NRF2?, 1,   NRF2↓, 18,   NRF2↑, 440,   NRF2⇅, 1,   NRF2↝, 2,   NRF2∅, 2,   p‑NRF2↑, 2,   ONOO↓, 1,   Prx↑, 4,   RNS↓, 4,   ROS?, 1,   ROS↓, 324,   ROS↑, 11,   ROS⇅, 4,   ROS∅, 3,   i-ROS↑, 1,   mt-ROS?, 1,   mt-ROS↓, 2,   selenoP↑, 1,   SOD?, 1,   SOD↓, 2,   SOD↑, 167,   SOD↝, 1,   SOD1↑, 11,   SOD2↓, 1,   SOD2↑, 7,   TAC↑, 25,   TBARS↓, 6,   Thiols↑, 1,   TOS↓, 1,   Trx↓, 1,   Trx↑, 7,   Trx1↑, 6,   TrxR↑, 3,   TrxR1↑, 3,   UCPs↑, 1,   uricA↓, 3,   VitC↑, 4,   VitE↓, 1,   VitE↑, 3,   xCT/SLC7A11↓, 1,   xCT/SLC7A11↑, 3,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↑, 2,   FTH1↓, 1,   FTH1↑, 1,   IronCh↓, 1,   IronCh↑, 16,   Mets↝, 1,   NCOA4↝, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compI↑, 1,   compII↑, 1,   compIII↑, 1,   DRP1/DNM1L↓, 3,   EGF↓, 1,   FIS1↓, 1,   Insulin↑, 1,   MFN2↑, 2,   mitResp↑, 2,   mtDam↓, 17,   mtDam↑, 1,   NGB↑, 1,   OCR↑, 1,   PDH↑, 1,   PGC-1α↑, 9,   PGC-1α↝, 2,   PINK1↓, 1,   PINK1↑, 2,   SIRT3↑, 4,   TFAM↑, 3,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 3,   3MST/MPST↑, 1,   5LO↓, 5,   ACC↓, 1,   Acetyl-CoA↑, 1,   ACSL4↓, 3,   ACSL4∅, 1,   ALAT↓, 32,   ALDOC↑, 1,   AMPK↓, 2,   AMPK↑, 26,   p‑AMPK↑, 3,   ATP↓, 1,   ATP↑, 15,   Buty↑, 1,   cAMP↑, 3,   CBS↑, 1,   CRM↑, 3,   cytoP450↓, 1,   DGAT1↓, 1,   FABP4↓, 1,   FAO↓, 1,   FASN↓, 3,   G6PD↑, 2,   GAPDH↑, 1,   glucose↓, 4,   glucose↑, 2,   glucose↝, 2,   GlucoseCon↓, 1,   GlucoseCon↑, 6,   Glycolysis↑, 3,   GSK‐3β↓, 24,   GSK‐3β↑, 3,   p‑GSK‐3β↓, 1,   p‑GSK‐3β↑, 6,   H2S↑, 3,   HK2↓, 1,   HK2↑, 2,   HMG-CoA↓, 1,   LDHA↓, 1,   LDL↓, 12,   lipidLev↓, 1,   lipoGen↓, 1,   NAD↓, 1,   NAD↑, 1,   NADH:NAD↑, 1,   NADPH↓, 11,   NADPH↑, 9,   NADPH∅, 1,   PDKs↓, 1,   PFK↓, 1,   PFK↑, 1,   PKM2↓, 2,   PKM2↑, 1,   PONs↑, 1,   SCFAs↑, 2,   SIRT1↓, 2,   SIRT1↑, 24,   SIRT1↝, 1,   SIRT2↑, 1,   SREBF2⇅, 1,   SREBP1/SREBF1↓, 2,  

Cell Death(tgid=5) ⓘ

AIF↓, 4,   Apoptosis↓, 47,   Apoptosis↑, 2,   ASC↓, 1,   ASK1↓, 1,   BAX↓, 23,   BAX↑, 3,   Bax:Bcl2↓, 7,   Bcl-2↓, 4,   Bcl-2↑, 20,   Bcl-xL↓, 1,   Bcl-xL↑, 1,   BNIP3↓, 1,   Casp↓, 1,   Casp1↓, 4,   proCasp1↓, 1,   Casp12↓, 2,   Casp3?, 1,   Casp3↓, 39,   Casp3↑, 1,   Casp3∅, 1,   cl‑Casp3↓, 9,   cl‑Casp8↓, 1,   cl‑Casp8↑, 1,   Casp9↓, 12,   Casp9↑, 1,   Casp9∅, 1,   cl‑Casp9↓, 1,   Cyt‑c↓, 9,   Cyt‑c↑, 2,   Cyt‑c∅, 2,   Fas↓, 2,   Ferroptosis↓, 21,   Ferroptosis↑, 1,   GranB/GZMB↓, 1,   IAP1↓, 1,   iNOS↓, 53,   iNOS↑, 2,   necrosis↓, 1,   p38↓, 5,   p38↑, 1,   p‑p38↓, 3,   Pyro↓, 2,   survivin↓, 1,   TUNEL↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 8,   Akt↑, 29,   Akt↝, 1,   p‑Akt↑, 6,   e-Akt↑, 1,   AMPKα↑, 2,   CREB↑, 3,   p‑CREB↑, 3,   ERK↓, 11,   ERK↑, 10,   p‑ERK↓, 2,   p‑ERK↑, 3,   e-ERK↑, 1,   HCAR2↑, 1,   HGF/c-Met↑, 1,   IGF-1R↓, 1,   IKKα↓, 1,   IKKα↑, 1,   p‑IKKα↓, 1,   IκB?, 1,   IκB↑, 2,   JAK↓, 2,   JAK2↓, 1,   JAK2↑, 2,   JNK↓, 10,   JNK↑, 2,   p‑JNK↓, 6,   p‑JNK↑, 1,   LPAR1/EDG2↑, 1,   MAPK?, 1,   MAPK↓, 29,   MAPK↑, 4,   MAPK↝, 2,   p‑MAPK?, 1,   p‑MAPK↓, 2,   MEK↓, 1,   Mst1↓, 1,   mTOR↓, 8,   mTOR↑, 5,   p‑mTOR↓, 3,   PDGFR-BB↓, 2,   PDGFRB↓, 1,   PFKFB2↓, 1,   PI3K↓, 6,   PI3K↑, 24,   p‑PI3K↑, 1,   PKA↑, 2,   PKCδ↓, 2,   PKCδ↑, 3,   PP2A↑, 2,   PTEN↓, 3,   p‑PTEN↑, 1,   PTP1B↓, 1,   RIP1↓, 1,   STAT↓, 4,   STAT3↓, 8,   STAT3↑, 2,   STAT3↝, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 3,   ATF2↑, 1,   ATF4↓, 4,   ATF4↑, 1,   cJun↓, 3,   p‑cJun↓, 2,   cMyc↓, 1,   p‑cMyc↑, 1,   DNMT1↓, 2,   DNMT3A↓, 2,   DNMTs↓, 1,   FOXO↑, 1,   FOXO3↑, 3,   HDAC?, 1,   HDAC↓, 4,   HDAC↑, 1,   HDAC2↓, 1,   HDAC3↓, 1,   miR-34a↓, 1,   other↓, 5,   other↑, 9,   other↝, 11,   RUNX2↑, 1,   SOX2↑, 1,   tumCV↓, 1,   tumCV∅, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↓, 1,   CHOP/DDIT3↓, 9,   CHOP/DDIT3↑, 2,   eIF2α↓, 1,   p‑eIF2α↓, 1,   cl‑eIF2α↑, 1,   ER Stress↓, 15,   GRP78/BiP↓, 9,   GRP78/BiP↑, 4,   GRP94↑, 1,   HSP27↓, 1,   HSP70/HSPA5↓, 1,   HSP70/HSPA5↑, 7,   HSP70/HSPA5↝, 1,   HSPs↑, 3,   IRE1↓, 1,   NQO2↑, 1,   PERK↓, 1,   p‑PERK↑, 1,   UPR↓, 1,   UPR↑, 1,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG3↓, 1,   ATG5↓, 1,   ATG7↓, 1,   autophagy↓, 1,   autophagy↑, 1,   Beclin-1/ATG6↓, 3,   Beclin-1/ATG6↑, 3,   LC3‑Ⅱ/LC3‑Ⅰ↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3B↓, 1,   LC3B↑, 1,   LC3II↓, 1,   LC3II↑, 1,   LC3s↓, 1,   MitoP↓, 1,   MitoP↑, 3,   p62↓, 2,   p62↑, 6,   PARK2↑, 3,   TFEB↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

p‑BRCA1↑, 1,   DNAdam↓, 12,   DNArepair↑, 1,   P53↓, 4,   PARP↓, 1,   PARP∅, 1,   PARP1↓, 1,   cl‑PARP1↓, 1,   PCNA↓, 1,   PCNA↑, 1,   SIRT6↑, 1,   Telomerase↓, 1,   TOP1↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK5↓, 2,   cycD1/CCND1↓, 1,   E2Fs↑, 1,   GADD34↓, 1,   GADD45A↑, 1,   Ki-67↓, 3,   Ki-67↑, 1,   P21↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMP2↑, 1,   CEBPA↓, 1,   cFos↓, 1,   CHIP↑, 1,   Choline↑, 1,   Diff↓, 1,   Diff↑, 1,   Diff↝, 1,   HH↓, 1,   IGF-1↓, 2,   Ki-67↓, 3,   Ki-67↑, 1,   mTORC1↓, 1,   Nestin↑, 1,   neuroG↑, 9,   NOTCH1↑, 1,   p300↓, 1,   TumCP↓, 3,   Wnt↑, 2,  

Migration(tgid=13) ⓘ

AntiAg↓, 2,   AntiAg↑, 11,   AP-1↓, 3,   AP-1↑, 1,   mt-ATPase↑, 1,   Ca+2↓, 11,   Ca+2↑, 2,   Ca+2↝, 3,   i-Ca+2↓, 1,   cal2↓, 1,   Cartilage↑, 3,   COL1↓, 2,   COL1↑, 1,   E-cadherin↑, 1,   EMT↓, 1,   Fibrosis↓, 1,   heparanase↑, 1,   LRP1↑, 1,   MMP1↓, 1,   MMP2↓, 4,   MMP2↑, 2,   MMP7↓, 1,   MMP9↓, 8,   MMP9↑, 1,   MMPs↓, 2,   MUC1↑, 1,   Na+↑, 1,   NFAT↓, 1,   p‑Rac1↓, 1,   Rho↓, 1,   ROCK1↓, 1,   SMAD3↓, 1,   p‑T-cadherin↓, 1,   TG2/TGase↓, 1,   TGF-β↓, 9,   TGF-β↑, 2,   TGF-β1↓, 3,   TGF-β1↑, 2,   TIMP1↓, 1,   TregCell↑, 1,   TumCI↓, 2,   TumCMig↓, 1,   TXNIP↓, 4,   TXNIP↑, 1,   uPA↑, 1,   Vim↓, 1,   α-SMA↓, 4,   β-catenin/ZEB1↑, 2,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 2,   angioG↑, 2,   E-sel↓, 3,   ECM/TCF↑, 1,   eNOS↑, 1,   p‑eNOS↑, 1,   HIF-1↓, 1,   Hif1a↓, 2,   Hif1a↑, 1,   NO↓, 37,   NO↑, 4,   TXA2↓, 1,   VCAM-1↓, 11,   VEGF↓, 5,   VEGF↑, 3,  

Barriers & Transport(tgid=15) ⓘ

BBB?, 1,   BBB↓, 3,   BBB↑, 43,   BBB↝, 1,   BBB∅, 2,   CLDN1↑, 2,   CLDN5↑, 1,   GastroP↑, 4,   GLUT1↑, 2,   GLUT2↑, 2,   GLUT3↑, 3,   GLUT4↑, 7,   H+/K+-ATPase↓, 1,   IBI↑, 5,   memfluid↑, 1,   MMP↓, 3,   MMP↑, 24,   MUC5AC↓, 1,   Na+↑, 1,   NHE3↑, 1,   OCLN↓, 1,   OCLN↑, 2,   TJ↑, 2,   TRPA1↑, 1,   TRPC1↓, 1,   TRPM7↓, 1,   TRPV1↑, 1,   TRPV3↑, 1,   ZO-1↑, 6,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

AIF1/Iba-1↓, 2,   BALF-Infl↓, 1,   CB2 / CNR2↑, 2,   CCL11↓, 1,   CD25+↑, 1,   CD4+↑, 2,   CD40↓, 1,   COX1↓, 1,   COX1↑, 1,   COX2/PTGS2↓, 76,   COX2/PTGS2↑, 2,   CXCc↓, 1,   FOXP3↑, 2,   HCAR2↑, 1,   HMGB1↓, 5,   ICAM-1↓, 9,   IFN-γ↓, 8,   IFN-γ↑, 3,   IgE↓, 1,   IL1↓, 5,   IL10↓, 11,   IL10↑, 14,   IL12↓, 5,   IL12↑, 1,   IL17↓, 8,   IL18↓, 3,   IL1α↓, 1,   IL1β↓, 99,   IL2↓, 6,   IL2↑, 1,   IL22↓, 1,   IL23↓, 3,   IL33↓, 2,   IL4↓, 7,   IL4↑, 3,   IL5↓, 1,   IL6↓, 97,   IL6↑, 4,   IL8↓, 14,   Imm↓, 1,   Imm↑, 4,   Imm↝, 1,   INF-γ↓, 3,   Inflam↓, 248,   Inflam↑, 2,   IP-10/CXCL-10↓, 2,   IRF3↓, 1,   LPS↓, 2,   M2 MC↑, 1,   pol-M2 MC↑, 1,   MCP1/CCL2↓, 11,   MCP1/CCL2↑, 1,   MIP‑1α/CCL3↓, 1,   MIP2↓, 2,   MyD88↓, 3,   NeuroI↓, 8,   NF-kB↓, 146,   NF-kB↑, 3,   NK cell↑, 2,   NLRP3↓, 39,   NLRP3↑, 1,   NOD1↓, 1,   p65↓, 5,   PGE2↓, 23,   PGE2↑, 1,   RAGE↓, 3,   RANTES↓, 2,   Th2↓, 1,   TLR1↓, 1,   TLR2↓, 4,   TLR4↓, 28,   TLR4↑, 1,   TNF-α↓, 139,   TRAF1↓, 1,   TRAF6↓, 1,   Treg lymp↝, 1,   TRIF↓, 2,  

Cellular Microenvironment(tgid=17) ⓘ

GFAP↓, 5,   pH↝, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5-AR↓, 1,   5HT↓, 1,   5HT↑, 6,   Ach↑, 9,   AChE↓, 45,   AChE↑, 1,   ADAM10↑, 2,   BChE↓, 7,   BDNF↓, 1,   BDNF↑, 47,   BDNF⇅, 1,   BDNF∅, 1,   BrainVol↑, 1,   ChAT↑, 8,   ChE↓, 1,   GABA↓, 1,   GABA↑, 3,   GDNF↑, 1,   MAOA↓, 7,   MAOB↓, 2,   NGF↑, 9,   PSD95↑, 6,   RELN↑, 1,   SNAP25↑, 3,   SYP↑, 1,   TPH1↓, 1,   TrkB↑, 5,   TrkB↝, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 3,   APP↓, 9,   Aβ↓, 54,   Aβ42↓, 6,   BACE/β-secretase↓, 25,   IDE↑, 2,   PSEN1/PS1↓, 1,   tau↓, 12,   p‑tau↓, 20,   XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 1,   ACE2↓, 1,   AhR↑, 3,   AKR1C3/17β-HSD5/PGF Synthase↑, 1,   AR↓, 1,   BNP↓, 1,   cortisol↓, 1,   CYP19↓, 1,   ER(estro)↓, 1,   ER(estro)↑, 1,   FGF21↑, 1,   GLP-1R↑, 1,   GR↑, 2,   GR↝, 1,   NR1H4↑, 1,   PPARα↑, 5,   PPARα↝, 1,   PPARγ↓, 3,   PPARγ↑, 18,   p‑PPARγ↓, 1,   RAAS↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

AKR1B1/ALR2↑, 1,   AKR1B10↝, 1,   BioAv?, 1,   BioAv↓, 44,   BioAv↑, 49,   BioAv↝, 32,   BioEnh↑, 1,   ChemoSen↑, 3,   CompStab↓, 1,   CompStab↑, 2,   CompStab↝, 1,   CYP1A1↑, 1,   CYP1A2↑, 1,   CYP2C6↑, 1,   CYP2D1↑, 1,   CYP2D6↓, 1,   CYP2E1↓, 2,   CYP3A2↑, 1,   Dose?, 1,   Dose↓, 1,   Dose↑, 3,   Dose↝, 39,   eff↓, 8,   eff↑, 40,   eff↝, 3,   GSTA1↓, 1,   GSTA1↑, 2,   GSTP1/GSTπ↓, 1,   GSTP1/GSTπ↑, 1,   Half-Life↓, 6,   Half-Life↑, 4,   Half-Life↝, 18,   Half-Life∅, 1,   MRP↓, 1,   P-gp/ABCB1↓, 1,   P450↑, 2,   selectivity↑, 2,   Synergy↑, 25,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 32,   ALB↑, 1,   ALP↓, 6,   AR↓, 1,   AST↓, 33,   BG↓, 2,   Bil↓, 1,   Bil↑, 2,   BloodF↑, 3,   BMD↑, 4,   BP↓, 8,   BP↝, 2,   BP∅, 1,   p‑BRCA1↑, 1,   BUN?, 1,   BUN↓, 6,   CEA↓, 1,   colonLen↑, 2,   creat↓, 13,   CRP↓, 10,   Ferritin↑, 2,   IL6↓, 97,   IL6↑, 4,   IRes↑, 1,   IRes↝, 1,   LDH↓, 12,   LDH↑, 3,   NOS2↓, 3,   RAGE↓, 3,   SpO2↑, 1,   TC↓, 3,   TG/TAG↓, 3,   TMAO↓, 1,   Urea↓, 3,   VLDL↓, 1,  

Functional Outcomes(tgid=23) ⓘ

Airway↓, 1,   Analgesic↑, 2,   AntiAge↑, 11,   antiAll?, 1,   antiAll↑, 18,   AntiArt↑, 6,   AntiCan↑, 22,   antiCG↑, 2,   AntiDiabetic↑, 16,   AntiMyl↑, 1,   antiPs↑, 2,   AntiTum↑, 8,   ANXi↓, 1,   cardioP?, 2,   cardioP↑, 79,   CardioT↓, 3,   chemoP↑, 19,   chemoPv↑, 3,   cognitive↓, 1,   cognitive↑, 86,   diuretic↑, 2,   fatigue↓, 1,   GFR↑, 1,   hepatoP↓, 3,   hepatoP↑, 73,   Learn↑, 14,   memory↑, 76,   Mood↑, 4,   motorD↓, 1,   motorD↑, 11,   Mucositis↓, 1,   neuroP↓, 1,   neuroP↑, 184,   NP/CIPN↓, 3,   Obesity↓, 17,   OS↑, 9,   Pain↓, 6,   QoL↓, 1,   QoL↑, 1,   radioP↑, 7,   RenoP↑, 36,   Risk↓, 2,   Sleep↑, 2,   Strength↑, 5,   Stress↓, 1,   Stroke↓, 18,   toxicity?, 1,   toxicity↓, 32,   toxicity↑, 2,   toxicity⇅, 1,   toxicity↝, 10,   toxicity∅, 7,   Weight↓, 3,   Weight↑, 2,   Weight∅, 1,   Wound Healing↓, 1,   Wound Healing↑, 3,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 12,   AntiFungal↑, 4,   AntiP↑, 2,   AntiViral↑, 11,   Bacteria↓, 19,   Diar↓, 3,   GutMicro↑, 35,   Sepsis↓, 9,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,   Ingr↑, 1,   Ingr↝, 7,  
Total Targets: 786

Scientific Paper Hit Count for: NRF2, nuclear factor erythroid 2-related factor 2
45 Sulforaphane (mainly Broccoli)
29 Curcumin
23 Luteolin
23 Quercetin
23 Thymoquinone
22 Resveratrol
19 Lycopene
17 EGCG (Epigallocatechin Gallate)
15 Shikonin
14 brusatol
14 Fisetin
13 Chemotherapy
13 Hydrogen Gas
13 Licochalcone A
13 Silymarin (Milk Thistle) silibinin
12 Alpha-Lipoic-Acid
12 Baicalein
11 doxorubicin
11 Ashwagandha(Withaferin A)
10 Cisplatin
10 Apigenin (mainly Parsley)
10 Chrysin
10 isoorientin
9 Silver-NanoParticles
9 Selenite (Sodium)
9 Artemisinin
9 Radiotherapy/Radiation
9 Selenium
8 Vitamin C (Ascorbic Acid)
8 Phenethyl isothiocyanate
8 Boron
8 Chlorogenic acid
8 Propolis -bee glue
8 Isoliquiritigenin
8 Kaempferol
8 Morin
8 Pterostilbene
8 Rosmarinic acid
7 Carnosic acid
7 Hyperoside
7 Piperlongumine
6 Allyl isothiocyanate
6 Allicin (mainly Garlic)
6 Berberine
6 Beta-Caryophyllene
6 Isothiocyanates
6 Honokiol
6 Isovitexin
5 Benzyl isothiocyanate
5 Betulinic acid
5 Boswellia (frankincense)
5 Crocetin
5 isoquercitrin
5 Melatonin
5 Mushroom Lion’s Mane, Hericium erinaceus
4 5-fluorouracil
4 Selenium NanoParticles
4 Vitexin
4 Matrine
4 Urolithin
3 Astaxanthin
3 Berbamine
3 xanthohumol
3 Brucea javanica
3 Capsaicin
3 Caffeic Acid Phenethyl Ester (CAPE)
3 Carvacrol
3 Centella asiatica / Gotu kola → asiaticoside
3 Cichoric acid / Chicoric acid
3 Cynaropicrin
3 Diindolylmethane
3 Disulfiram
3 Copper and Cu NanoParticles
3 Emodin
3 Ferulic acid
3 Gallic acid
3 Ginger/6-Shogaol/Gingerol
3 Ginkgetin
3 Linalool
3 Lutein
3 Magnetic Fields
3 Parthenolide
2 1,8-Cineole
2 Auranofin
2 Lapatinib
2 Thymol-Thymus vulgaris
2 methotrexate
2 Cinnamon
2 Carvone
2 Cucurbitacin
2 Chlorella (Chlorella vulgaris)
2 Cysteamine
2 Eugenol
2 Ginkgo biloba
2 Ginseng
2 Hydroxycinnamic-acid
2 HydroxyTyrosol
2 Isorhamnetin
2 Licorice
2 Magnolol
2 methylseleninic acid
2 Metformin
2 Moringa oleifera
2 Methylsulfonylmethane
2 Nimbolide
2 salinomycin
2 Taurine
1 Andrographis
1 Docetaxel
1 Baicalin
1 Biochanin A
1 Cannabidiol
1 buckwheat sprouts
1 Butyrate
1 Caffeic acid
1 Catechins
1 Cynanbungeigenin C (CBC) and D (CBD)
1 Camu camu
1 Celastrol
1 chaetocin
1 chitosan
1 Calorie Restriction Mimetics
1 Cynara scolymus/Globe Artichoke/Artichoke Extract
1 Ursolic acid
1 Spirulina(Arthrospira/Limnospira)
1 diet FMD Fasting Mimicking Diet
1 diet Methionine-Restricted Diet
1 Indole-3-carbinol
1 D-limonene
1 Dandelion Root
1 Ellagic acid
1 Formononetin
1 Fucoidan
1 Shilajit/Fulvic Acid
1 Geraniol
1 Gossypol/AT-101
1 hydrogen sulfide
1 HydroxyCitric Acid
1 Isobavachalcone
1 iodine
1 Juglone
1 lambertianic acid
1 Modified Citrus Pectin
1 Methyl salicylate / Sweet Birch oil
1 Aspirin
1 Moringin
1 Mangiferin
1 Lemon Balm/Melissa officinalis
1 Zeolite
1 Myricetin
1 Oleuropein
1 Purple Corn / Purple Maize
1 Propyl gallate
1 Phenolic Acids
1 Piperine
1 Plumbagin
1 Polyphenols
1 Sulfasalazine
1 Oxygen, Hyperbaric
1 irinotecan
1 acetazolamide
1 Salvia miltiorrhiza
1 Spermidine
1 erastin
1 Terminalia bellirica
1 Terpenoids
1 triptolide
1 Vanillic Acid
1 Mung Bean Sprouts
1 Vitamin B1/Thiamine
1 Vitamin D3
1 Vitamin K2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:226  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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