eff Cancer Research Results

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2496- Fenb,    Impairment of the Ubiquitin-Proteasome Pathway by Methyl N-(6-Phenylsulfanyl-1H-benzimidazol-2-yl)carbamate Leads to a Potent Cytotoxic Effect in Tumor Cells
- in-vitro, NSCLC, A549 - in-vitro, NSCLC, H460
TumCG↓, selectivity↑, P53↑, IKKα↑, ER Stress↑, GRP78/BiP↑, CHOP↑, ATF3↑, IRE1↑, NOXA↑, ROS↑, MMP↓, Cyt‑c↑, selectivity↑, eff↝,
2494- Fenb,    Oral Fenbendazole for Cancer Therapy in Humans and Animals
- Review, Var, NA
Glycolysis↓, GlucoseCon↓, ROS↑, Apoptosis↑, BioAv↓, eff↑, toxicity↓, BioAv↑, BioAv↑, hepatoP↓, eff↑,
2495- Fenb,    Benzimidazoles Downregulate Mdm2 and MdmX and Activate p53 in MdmX Overexpressing Tumor Cells
- in-vitro, Melanoma, A375
P53↑, P21↑, TumCCA↑, MDM2↓, MDMX↓, eff↑,
1914- Fer,  VitC,  TMZ,  Rad,    Pharmacologic Ascorbate and Ferumoxytol Combined with Temozolomide and Radiation Therapy for the Treatment of Newly Diagnosed Glioblastoma
- Trial, GBM, NA
eff↑,
1915- Fer,    Vascular Imaging With Ferumoxytol as a Contrast Agent
- Analysis, Var, NA
eff↑, toxicity↓, other?,
2847- FIS,    Fisetin-induced cell death, apoptosis, and antimigratory effects in cholangiocarcinoma cells
- in-vitro, CCA, NA
tumCV↓, ChemoSen↑, TumCMig↓, ROS↑, TumCI↓, angioG↓, CDK2↓, PI3K↓, Akt↓, mTOR↓, EGFR↓, Casp↑, mTORC1↓, mTORC2↑, cycD1/CCND1↓, cycE/CCNE↓, MMP2↓, MMP9↓, ER Stress↑, Ca+2↑, eff↓,
2849- FIS,    Activation of reactive oxygen species/AMP activated protein kinase signaling mediates fisetin-induced apoptosis in multiple myeloma U266 cells
- in-vitro, Melanoma, U266
TumCD↑, TumCCA↑, Casp3↑, Bcl-2↓, Mcl-1↓, BAX↑, BIM↑, BAD↑, AMPK↑, ACC↑, p‑Akt↓, p‑mTOR↓, ROS↑, eff↓,
2854- FIS,    New Perspectives for Fisetin
- Review, Var, NA - Review, Stroke, NA
Inflam↓, ChemoSen↑, chemoPv↑, eff↑, memory↑, neuroP↑, *Dose↑, BioAv↓, BBB↑,
2855- FIS,    Fisetin Induces Apoptosis Through p53-Mediated Up-Regulation of DR5 Expression in Human Renal Carcinoma Caki Cells
- in-vitro, RCC, Caki-1
TumCCA↑, cl‑PARP↑, Apoptosis↑, Casp↑, P53↑, DR5↑, CHOP↑, ROS↑, ER Stress↑, ATF4↑, XBP-1↑, eff∅,
2856- FIS,    N -acetyl- L -cysteine enhances fisetin-induced cytotoxicity via induction of ROS-independent apoptosis in human colonic cancer cells
- in-vitro, Colon, COLO205
eff↑, ROS↑, tumCV↓, Casp3↑, Bcl-2↓, MMP↓, eff↑,
2857- FIS,    A review on the chemotherapeutic potential of fisetin: In vitro evidences
- Review, Var, NA
COX2↓, PGE2↓, EGFR↓, Wnt↓, β-catenin/ZEB1↓, TCF↑, Apoptosis↑, Casp3↑, cl‑PARP↑, Bcl-2↓, Mcl-1↓, BAX↑, BIM↑, BAD↑, Akt↓, mTOR↓, ACC↑, Cyt‑c↑, Diablo↑, cl‑Casp8↑, Fas↑, DR5↑, TRAIL↑, Securin↓, CDC2↓, CDC25↓, HSP70/HSPA5↓, CDK2↓, CDK4↓, cycD1/CCND1↓, MMP2↓, uPA↓, NF-kB↓, cFos↓, cJun↓, MEK↓, p‑ERK↓, N-cadherin↓, Vim↓, Snail↓, Fibronectin↓, E-cadherin↓, NF-kB↑, ROS↑, DNAdam↑, MMP↓, CHOP↑, eff↑, ChemoSen↑,
2861- FIS,    The neuroprotective effects of fisetin, a natural flavonoid in neurodegenerative diseases: Focus on the role of oxidative stress
- Review, Nor, NA - Review, Stroke, NA - Review, Park, NA
*antiOx↑, *ROS↓, *neuroP↑, *NO↑, BioAv↝, *BBB↑, *toxicity↑, *eff↑, *GSH↑, *SOD↑, *Aβ↓, *12LOX↓, *COX2↓, *Catalase↑, *Inflam↓, *TNF-α↓, *IL6↑, *lipid-P↓, NF-kB↓, IL1β↓, NRF2↑, HO-1↑, GSTs↑, cognitive↑, *BDNF↑,
2845- FIS,    Fisetin: A bioactive phytochemical with potential for cancer prevention and pharmacotherapy
- Review, Var, NA
PI3K↓, Akt↓, mTOR↓, p38↓, *antiOx↑, *neuroP↑, Casp3↑, Bcl-2↓, Mcl-1↓, BAX↑, BIM↑, BAD↑, AMPK↑, ACC↑, DNAdam↑, MMP↓, eff↑, ROS↑, cl‑PARP↑, Cyt‑c↑, Diablo↑, P53↑, p65↓, Myc↓, HSP70/HSPA5↓, HSP27↓, COX2↓, Wnt↓, EGFR↓, NF-kB↓, TumCCA↑, CDK2↓, CDK4↓, cycD1/CCND1↓, cycA1/CCNA1↓, P21↑, MMP2↓, MMP9↓, TumMeta↓, MMP1↓, MMP3↓, MMP7↓, MET↓, N-cadherin↓, Vim↓, Snail↓, Fibronectin↓, E-cadherin↑, uPA↓, ChemoSen↑, EMT↓, Twist↓, Zeb1↓, cFos↓, cJun↓, EGF↓, angioG↓, VEGF↓, eNOS↓, *NRF2↑, HO-1↑, NRF2↓, GSTs↓, ATF4↓,
2825- FIS,    Exploring the molecular targets of dietary flavonoid fisetin in cancer
- Review, Var, NA
*Inflam↓, *antiOx↓, *ERK↑, *p‑cMyc↑, *NRF2↑, *GSH↑, *HO-1↑, mTOR↓, PI3K↓, Akt↓, TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, CDK6↓, P21↑, p27↑, JNK↑, MMP2↓, MMP9↓, uPA↓, NF-kB↓, cFos↓, cJun↓, E-cadherin↑, Vim↓, N-cadherin↓, EMT↓, MMP↓, Cyt‑c↑, Diablo↑, Casp↑, cl‑PARP↑, P53↑, COX2↓, PGE2↓, HSP70/HSPA5↓, HSP27↓, DNAdam↑, Casp3↑, Casp9↑, ROS↑, AMPK↑, NO↑, Ca+2↑, mTORC1↓, p70S6↓, ROS↓, ER Stress↑, IRE1↑, ATF4↑, GRP78/BiP↑, eff↑, eff↑, eff↑, RadioS↑, ChemoSen↑, Half-Life↝,
2839- FIS,    Dietary flavonoid fisetin for cancer prevention and treatment
- Review, Var, NA
DNAdam↑, ROS↑, Apoptosis↑, Bcl-2↓, BAX↑, cl‑Casp9↑, cl‑Casp3↑, Cyt‑c↑, lipid-P↓, TumCG↓, TumCA↓, TumCMig↓, TumCI↓, uPA↓, ERK↓, MMP9↓, NF-kB↓, cFos↓, cJun↓, AP-1↓, TumCCA↑, AR↓, mTORC1↓, mTORC2↓, TSC2↑, EGF↓, TGF-β↓, EMT↓, P-gp↓, PI3K↓, Akt↓, mTOR↓, eff↑, ROS↓, ER Stress↑, IRE1↑, ATF4↑, GRP78/BiP↑, ChemoSen↑, CDK2↓, CDK4↓, cycE/CCNE↓, cycD1/CCND1↓, P21↑, COX2↓, Wnt↓, EGFR↓, β-catenin/ZEB1↓, TCF-4↓, MMP7↓, RadioS↑, eff↑,
2842- FIS,    Fisetin inhibits cellular proliferation and induces mitochondria-dependent apoptosis in human gastric cancer cells
- in-vitro, GC, AGS
TumCCA↑, CDK2↓, P53↑, selectivity↑, MMP↓, DNAdam↑, cl‑PARP↑, mt-ROS↑, eff↓, survivin↓,
5392- FIS,  AsP,    Fisetin topical delivery via ascorbyl palmitate/hyaluronan-enhanced limosomes: a novel paradigm for preventing UVB-induced skin photoaging
- in-vivo, Nor, NA
eff↑, *antiOx↑, *MMP9↓, *TNF-α↓, *NF-kB↓, *SOD↑, *Catalase↑, *AntiAge↑, *Inflam↓, *JNK↓,
2642- Flav,  QC,  Api,  KaempF,  MCT  In Vitro–In Vivo Study of the Impact of Excipient Emulsions on the Bioavailability and Antioxidant Activity of Flavonoids: Influence of the Carrier Oil Type
- in-vitro, Nor, NA - in-vivo, Nor, NA
*BioAv↑, *eff↝, BioEnh↑,
4107- FLS,  Ex,    Combined effects of aerobic exercise and 40-Hz light flicker exposure on early cognitive impairments in Alzheimer's disease of 3×Tg mice
- in-vivo, AD, NA
*Aβ↓, *cognitive↑, *Inflam↓, *eff↑,
5152- GamB,    Gambogic Acid as a Candidate for Cancer Therapy: A Review
- Review, Var, NA
AntiCan↑, Apoptosis↑, TumAuto↑, TumCCA↑, TumCI↓, TumMeta↓, angioG↓, eff↑, NF-kB↓, P53↑, P21↑, MDM2↓, HSP90↓, Bcl-2↓, Cyt‑c↑, Casp↑, MMP↓, Casp3↑, Casp9↑, cl‑PARP↑, Bax:Bcl2↑, ROS↑, SIRT1↓, TrxR1↓, Fas↓, FasL↑, FADD↑, APAF1↑, DNAdam↑, NF-kB↓, STAT3↓, MAPK↓, cFos↓, EGFR↓, Akt↓, mTOR↓, AMPK↑, TumCCA↑, ChemoSen↑, P-gp↓, survivin↓,
5148- GamB,    Gambogic acid: A shining natural compound to nanomedicine for cancer therapeutics
- Review, Var, NA
AntiCan↑, angioG↓, ChemoSen↑, RadioS↑, VEGF↓, MMP2↓, MMP9↓, Telomerase↓, TrxR↓, ERK↓, HSP90↓, ROS↑, SIRT1↑, survivin↓, cFLIP↓, Casp3↑, Casp8↑, Casp9↑, BAD↓, BID↓, Bcl-2↓, BAX↑, STAT3↓, hTERT/TERT↓, NF-kB↓, Myc↓, Hif1a↓, FOXD3↑, BioAv↓, BioAv↑, P53↑, eff↓, OCR↓, MMP↓, PI3K↓, Akt↓, BBB↑, TumCG↓, TumMeta↓, BioAv↑,
5150- GamB,    Gambogic acid, a novel ligand for transferrin receptor, potentiates TNF-induced apoptosis through modulation of the nuclear factor-κB signaling pathway
- in-vitro, CLL, KBM-5 - in-vitro, Nor, HEK293
Apoptosis↑, ChemoSen↑, IAP1↓, IAP2↓, Bcl-2↓, Bcl-xL↓, TRAF1↓, cycD1/CCND1↓, cMyc↓, COX2↓, MMP9↓, angioG↓, VEGF↓, NF-kB↓, eff↓,
1955- GamB,    Gambogic acid inhibits thioredoxin activity and induces ROS-mediated cell death in castration-resistant prostate cancer
- in-vitro, Pca, PC3 - in-vitro, Pca, LNCaP - in-vitro, Pca, DU145
ROS↑, Apoptosis↑, Ferroptosis↑, Trx↓, eff↑, TrxR↓, Dose∅, MMP↓, eff↑, Casp↑, NADPH↓, TrxR↓, ChemoSen↑, AR↓,
1957- GamB,    Nanoscale Features of Gambogic Acid Induced ROS-Dependent Apoptosis in Esophageal Cancer Cells Imaged by Atomic Force Microscopy
- in-vitro, ESCC, EC9706
AntiCan↑, toxicity↓, TumCP↓, Apoptosis↑, TumCCA↑, MMP↓, ROS↑, eff↓, RadioS↑,
1958- GamB,    Gambogenic acid induces apoptosis and autophagy through ROS-mediated endoplasmic reticulum stress via JNK pathway in prostate cancer cells
- in-vitro, Pca, NA - in-vivo, NA, NA
AntiCan↑, TumCP↓, TumAuto↑, eff↑, JNK↑, ROS↑, ER Stress↑, eff↓, TumCG↓,
1959- GamB,    Gambogic acid induces GSDME dependent pyroptotic signaling pathway via ROS/P53/Mitochondria/Caspase-3 in ovarian cancer cells
- in-vitro, Ovarian, NA - in-vivo, NA, NA
AntiCan↑, Pyro↑, tumCV?, CellMemb↓, cl‑Casp3↑, GSDME-N↑, ROS?, p‑P53↑, eff↓, MMP↓, Bcl-2↓, BAX↑, mtDam↑, Cyt‑c↑, TumCG↓, CD4+↑, CD8+↑,
1960- GamB,  Vem,    Calcium channel blocker verapamil accelerates gambogic acid-induced cytotoxicity via enhancing proteasome inhibition and ROS generation
- in-vitro, Liver, HepG2 - in-vitro, AML, K562
Proteasome↓, eff↑, Casp↑, ER Stress↑, ROS↑, eff↑,
1961- GamB,    Effects of gambogic acid on the activation of caspase-3 and downregulation of SIRT1 in RPMI-8226 multiple myeloma cells via the accumulation of ROS
- in-vitro, Melanoma, RPMI-8226
TumCG↓, Apoptosis↑, ROS↑, Casp3↑, cl‑PARP↑, SIRT1↓, eff↓,
1962- GamB,  HCQ,    Gambogic acid induces autophagy and combines synergistically with chloroquine to suppress pancreatic cancer by increasing the accumulation of reactive oxygen species
- in-vitro, PC, NA
LC3II↑, Beclin-1↑, p62↓, MMP↓, ROS↑, TumAuto↑, eff↑,
1965- GamB,  doxoR,    Gambogic acid sensitizes ovarian cancer cells to doxorubicin through ROS-mediated apoptosis
- in-vitro, Ovarian, SKOV3
eff↑, AntiCan↑, ROS↑, ChemoSen↑,
1966- GamB,  Cisplatin,    Gambogic acid synergistically potentiates cisplatin-induced apoptosis in non-small-cell lung cancer through suppressing NF-κB and MAPK/HO-1 signalling
- in-vitro, Lung, A549 - in-vitro, Lung, NCIH1299
TumCCA↑, PARP↑, eff↑, ROS↑, ChemoSen↑,
1970- GamB,    Gambogic acid-induced autophagy in nonsmall cell lung cancer NCI-H441 cells through a reactive oxygen species pathway
- NA, Lung, NCI-H441
TumCG↓, TumAuto↑, Beclin-1↑, LC3‑Ⅱ/LC3‑Ⅰ↑, ROS↑, eff↓,
1971- GamB,    Gambogic acid triggers vacuolization-associated cell death in cancer cells via disruption of thiol proteostasis
- in-vitro, Nor, MCF10 - in-vitro, BC, MDA-MB-435 - in-vitro, BC, MDA-MB-468 - in-vivo, NA, NA
Paraptosis↑, ER Stress↑, MMP↓, eff↓, selectivity↑, p‑ERK↑, p‑JNK↑, eff↓,
1972- GamB,  doxoR,    Gambogic acid sensitizes resistant breast cancer cells to doxorubicin through inhibiting P-glycoprotein and suppressing survivin expression
- in-vitro, BC, NA
eff↑, P-gp↓, ROS↑, survivin↓, p38↑,
2060- GamB,    Gambogenic acid induces apoptosis and autophagy through ROS-mediated endoplasmic reticulum stress via JNK pathway in prostate cancer cells
- in-vitro, Pca, NA
TumCP↓, TumAuto↑, eff↑, ROS↑, ER Stress↑, JNK↑,
823- GAR,    Garcinol Potentiates TRAIL-Induced Apoptosis through Modulation of Death Receptors and Antiapoptotic Proteins
- in-vitro, BC, MCF-7 - in-vitro, Nor, MCF10 - in-vitro, CRC, HCT116
Casp3↑, Casp9↑, Casp8↑, DR5↑, survivin↓, Bcl-2↓, XIAP↓, cFLIP↓, BAX↑, Cyt‑c↑, ROS↑, GSH↓, *eff↓,
1435- GEN,  SFN,    The Effects of Combinatorial Genistein and Sulforaphane in Breast Tumor Inhibition: Role in Epigenetic Regulation
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF-7
DNMTs↓, HDAC↓, eff↑, TumCCA↑, HMTs↓, HDAC2↓, HDAC3↓, KLF4↓, hTERT/TERT↓,
4664- GEN,  CUR,  RES,  EGCG,  SFN  Targeting cancer stem cells by nutraceuticals for cancer therapy
- Review, Var, NA
CSCs↓, other↝, eff↑, CD44↓, p‑STAT3↓,
4302- Gins,    Panax ginseng: A modulator of amyloid, tau pathology, and cognitive function in Alzheimer's disease
- Review, AD, NA
*neuroP↑, *Aβ↓, *p‑tau↓, *cognitive↑, *eff↑, *PKA↑, *CREB↑, *BACE↓, *ADAM10↑, *MAPK↑, *ERK↑, *PI3K↑, *Akt↑, *NRF2↑, *PPARγ↓, *IDE↑, *APP↓, *PP2A↑, *memory↑,
4301- Gins,    Red Ginseng Inhibits Tau Aggregation and Promotes Tau Dissociation In Vitro
- in-vitro, AD, NA
*p‑tau↓, *eff↑, *Inflam↓,
4513- GLA,    Antineoplastic Effects of Gamma Linolenic Acid on Hepatocellular Carcinoma Cell Lines
- in-vitro, Liver, HUH7
TumCP↓, ROS↑, Apoptosis↑, HO-1↑, Trx↑, lipid-P↑, eff↓, MMP↓, DNAdam↑, selectivity↑,
4510- GLA,    Gamma-linolenic acid therapy of human glioma-a review of in vitro, in vivo, and clinical studies
- Review, NA, NA
Apoptosis↑, selectivity↑, eff↓, ROS↑, lipid-P↑, P53↑, radioP↑, chemoP↑,
1904- GoldNP,  AgNPs,    Unveiling the Potential of Innovative Gold(I) and Silver(I) Selenourea Complexes as Anticancer Agents Targeting TrxR and Cellular Redox Homeostasis
- in-vitro, Lung, H157 - in-vitro, BC, MCF-7 - in-vitro, Colon, HCT15 - in-vitro, Melanoma, A375
TrxR↓, selectivity↑, eff↑, eff↝, ROS↑, MMP↓, Apoptosis↑, eff↑,
5390- GoldNP,  GEM,  AsP,    Optimizing Gold Nanoparticles for Combination Therapy: Development of Hydrophobic Nanomedical Devices with Gemcitabine and Ascorbyl Palmitate
- in-vitro, BC, 4T1
EPR↑, eff↑,
6062- GoldNP,  SeNPs,    Nanotechnology-based Targeting of Neurodegenerative Disorders: A Promising Tool for Efficient Delivery of Neuromedicines
- Review, AD, NA
*DDS↑, *BBB↑, *eff↑,
2517- H2,    Molecular Hydrogen Enhances Proliferation of Cancer Cells That Exhibit Potent Mitochondrial Unfolded Protein Response
- in-vitro, Var, A549 - in-vitro, NA, HCT116 - in-vitro, NA, HeLa - in-vitro, NA, HepG2 - in-vitro, NA, HT1080 - in-vitro, NA, PC3 - in-vitro, NA, SH-SY5Y
TumCP↓, other↝, eff↝, mt-UPR↑,
2516- H2,    Hydrogen Gas in Cancer Treatment
- Review, Var, NA
*Half-Life↓, *ROS↓, *selectivity↑, *SOD↑, *HO-1↑, *NRF2↑, *chemoP↑, *radioP↑, ROS↑, *Inflam↓, eff↑, *TNF-α↓, *IL6↓, *cl‑Casp8↑, *Bax:Bcl2↓, *Apoptosis↓, *cardioP↑, *hepatoP↑, *RenoP↑, *chemoP↑, eff↝, chemoP↑, radioP↑, eff↑, TumCG↓, Ki-67↓, VEGF↓, selectivity↑,
2509- H2,    Hydrogen inhibits endometrial cancer growth via a ROS/NLRP3/caspase-1/GSDMD-mediated pyroptotic pathway
- in-vitro, Endo, AN3CA - in-vivo, Endo, NA
selectivity↑, mt-ROS↑, ROS↑, TumW↓, GSDMD↑, Pyro↑, Dose↝, eff↓, TumVol↓,
2508- H2,    Molecular hydrogen is a promising therapeutic agent for pulmonary disease
- Review, Var, NA - Review, Sepsis, NA
*ROS↓, eff↝, *Inflam↓, *NRF2↑, *HO-1↑, *SOD↑, *Catalase↑, *MPO↑, *ASK1↓, *NADPH↓, *Sepsis↓, *HMGB1↓, ROS↑, NLRP3↑, GSDMD↑, chemoP↑, eff↑,
2504- H2,    Hydrogen gas activates coenzyme Q10 to restore exhausted CD8+ T cells, especially PD-1+Tim3+terminal CD8+ T cells, leading to better nivolumab outcomes in patients with lung cancer
- Trial, Lung, NA
CD8+↑, OS↑, eff↝, CoQ10↑, PDT+↓, PGC-1α↑, Dose↝, *toxicity∅,

Showing Research Papers: 651 to 700 of 1283
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1283

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ATF3↑, 1,   CoQ10↑, 1,   Ferroptosis↑, 1,   GSH↓, 1,   GSTs↓, 1,   GSTs↑, 1,   HO-1↑, 3,   lipid-P↓, 1,   lipid-P↑, 2,   NRF2↓, 1,   NRF2↑, 1,   ROS?, 1,   ROS↓, 2,   ROS↑, 30,   mt-ROS↑, 2,   Trx↓, 1,   Trx↑, 1,   TrxR↓, 4,   TrxR1↓, 1,  

Mitochondria & Bioenergetics ⓘ

CDC2↓, 1,   CDC25↓, 1,   EGF↓, 2,   MEK↓, 1,   MMP↓, 15,   mtDam↑, 1,   OCR↓, 1,   PGC-1α↑, 1,   XIAP↓, 1,  

Core Metabolism/Glycolysis ⓘ

ACC↑, 3,   AMPK↑, 4,   cMyc↓, 1,   GlucoseCon↓, 1,   Glycolysis↓, 1,   NADPH↓, 1,   SIRT1↓, 2,   SIRT1↑, 1,  

Cell Death ⓘ

Akt↓, 7,   p‑Akt↓, 1,   APAF1↑, 1,   Apoptosis↑, 12,   BAD↓, 1,   BAD↑, 3,   BAX↑, 7,   Bax:Bcl2↑, 1,   Bcl-2↓, 10,   Bcl-xL↓, 1,   BID↓, 1,   BIM↑, 3,   Casp↑, 6,   Casp3↑, 9,   cl‑Casp3↑, 2,   Casp8↑, 2,   cl‑Casp8↑, 1,   Casp9↑, 4,   cl‑Casp9↑, 1,   cFLIP↓, 2,   Cyt‑c↑, 8,   Diablo↑, 3,   DR5↑, 3,   FADD↑, 1,   Fas↓, 1,   Fas↑, 1,   FasL↑, 1,   Ferroptosis↑, 1,   GSDMD↑, 2,   GSDME-N↑, 1,   hTERT/TERT↓, 2,   IAP1↓, 1,   IAP2↓, 1,   JNK↑, 3,   p‑JNK↑, 1,   MAPK↓, 1,   Mcl-1↓, 3,   MDM2↓, 2,   Myc↓, 2,   NOXA↑, 1,   p27↑, 1,   p38↓, 1,   p38↑, 1,   Paraptosis↑, 1,   Proteasome↓, 1,   Pyro↑, 2,   survivin↓, 5,   Telomerase↓, 1,   TRAIL↑, 1,   TumCD↑, 1,  

Kinase & Signal Transduction ⓘ

FOXD3↑, 1,   p70S6↓, 1,   TSC2↑, 1,  

Transcription & Epigenetics ⓘ

cJun↓, 4,   other?, 1,   other↝, 2,   tumCV?, 1,   tumCV↓, 2,  

Protein Folding & ER Stress ⓘ

CHOP↑, 3,   ER Stress↑, 9,   GRP78/BiP↑, 3,   HSP27↓, 2,   HSP70/HSPA5↓, 3,   HSP90↓, 2,   IRE1↑, 3,   mt-UPR↑, 1,   XBP-1↑, 1,  

Autophagy & Lysosomes ⓘ

Beclin-1↑, 2,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3II↑, 1,   p62↓, 1,   TumAuto↑, 5,  

DNA Damage & Repair ⓘ

DNAdam↑, 7,   DNMTs↓, 1,   MDMX↓, 1,   P53↑, 9,   p‑P53↑, 1,   PARP↑, 1,   cl‑PARP↑, 7,  

Cell Cycle & Senescence ⓘ

CDK2↓, 6,   CDK4↓, 4,   cycA1/CCNA1↓, 1,   cycD1/CCND1↓, 6,   cycE/CCNE↓, 3,   P21↑, 5,   Securin↓, 1,   TumCCA↑, 12,  

Proliferation, Differentiation & Cell State ⓘ

CD44↓, 1,   cFos↓, 5,   CSCs↓, 1,   EMT↓, 3,   ERK↓, 2,   p‑ERK↓, 1,   p‑ERK↑, 1,   HDAC↓, 1,   HDAC2↓, 1,   HDAC3↓, 1,   HMTs↓, 1,   KLF4↓, 1,   mTOR↓, 6,   p‑mTOR↓, 1,   mTORC1↓, 3,   mTORC2↓, 1,   mTORC2↑, 1,   PI3K↓, 5,   STAT3↓, 2,   p‑STAT3↓, 1,   TCF↑, 1,   TCF-4↓, 1,   TumCG↓, 8,   Wnt↓, 3,  

Migration ⓘ

AP-1↓, 1,   Ca+2↑, 2,   E-cadherin↓, 1,   E-cadherin↑, 2,   Fibronectin↓, 2,   Ki-67↓, 1,   MET↓, 1,   MMP1↓, 1,   MMP2↓, 5,   MMP3↓, 1,   MMP7↓, 2,   MMP9↓, 6,   N-cadherin↓, 3,   Snail↓, 2,   TGF-β↓, 1,   TumCA↓, 1,   TumCI↓, 3,   TumCMig↓, 2,   TumCP↓, 5,   TumMeta↓, 3,   Twist↓, 1,   uPA↓, 4,   Vim↓, 3,   Zeb1↓, 1,   β-catenin/ZEB1↓, 2,  

Angiogenesis & Vasculature ⓘ

angioG↓, 5,   ATF4↓, 1,   ATF4↑, 3,   EGFR↓, 5,   eNOS↓, 1,   EPR↑, 1,   Hif1a↓, 1,   NO↑, 1,   VEGF↓, 4,  

Barriers & Transport ⓘ

BBB↑, 2,   CellMemb↓, 1,   P-gp↓, 3,  

Immune & Inflammatory Signaling ⓘ

CD4+↑, 1,   COX2↓, 5,   IKKα↑, 1,   IL1β↓, 1,   Inflam↓, 1,   NF-kB↓, 9,   NF-kB↑, 1,   p65↓, 1,   PDT+↓, 1,   PGE2↓, 2,   TRAF1↓, 1,  

Protein Aggregation ⓘ

NLRP3↑, 1,  

Hormonal & Nuclear Receptors ⓘ

AR↓, 2,   CDK6↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 3,   BioAv↑, 4,   BioAv↝, 1,   BioEnh↑, 1,   ChemoSen↑, 12,   Dose↝, 2,   Dose∅, 1,   eff↓, 15,   eff↑, 35,   eff↝, 6,   eff∅, 1,   Half-Life↝, 1,   RadioS↑, 4,   selectivity↑, 9,  

Clinical Biomarkers ⓘ

AR↓, 2,   EGFR↓, 5,   hTERT/TERT↓, 2,   Ki-67↓, 1,   Myc↓, 2,  

Functional Outcomes ⓘ

AntiCan↑, 6,   chemoP↑, 3,   chemoPv↑, 1,   cognitive↑, 1,   hepatoP↓, 1,   memory↑, 1,   neuroP↑, 1,   OS↑, 1,   radioP↑, 2,   toxicity↓, 3,   TumVol↓, 1,   TumW↓, 1,  

Infection & Microbiome ⓘ

CD8+↑, 2,  
Total Targets: 230

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↓, 1,   antiOx↑, 3,   Catalase↑, 3,   GSH↑, 2,   HO-1↑, 3,   lipid-P↓, 1,   MPO↑, 1,   NRF2↑, 5,   ROS↓, 3,   SOD↑, 4,  

Core Metabolism/Glycolysis ⓘ

12LOX↓, 1,   p‑cMyc↑, 1,   CREB↑, 1,   NADPH↓, 1,   PPARγ↓, 1,  

Cell Death ⓘ

Akt↑, 1,   Apoptosis↓, 1,   ASK1↓, 1,   Bax:Bcl2↓, 1,   cl‑Casp8↑, 1,   JNK↓, 1,   MAPK↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

ERK↑, 2,   PI3K↑, 1,  

Migration ⓘ

APP↓, 1,   MMP9↓, 1,   PKA↑, 1,  

Angiogenesis & Vasculature ⓘ

NO↑, 1,  

Barriers & Transport ⓘ

BBB↑, 2,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   HMGB1↓, 1,   IL6↓, 1,   IL6↑, 1,   Inflam↓, 7,   NF-kB↓, 1,   TNF-α↓, 3,  

Synaptic & Neurotransmission ⓘ

ADAM10↑, 1,   BDNF↑, 1,   p‑tau↓, 2,  

Protein Aggregation ⓘ

Aβ↓, 3,   BACE↓, 1,   IDE↑, 1,   PP2A↑, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↑, 1,   DDS↑, 1,   Dose↑, 1,   eff↓, 1,   eff↑, 5,   eff↝, 1,   Half-Life↓, 1,   selectivity↑, 1,  

Clinical Biomarkers ⓘ

IL6↓, 1,   IL6↑, 1,  

Functional Outcomes ⓘ

AntiAge↑, 1,   cardioP↑, 1,   chemoP↑, 2,   cognitive↑, 2,   hepatoP↑, 1,   memory↑, 1,   neuroP↑, 3,   radioP↑, 1,   RenoP↑, 1,   toxicity↑, 1,   toxicity∅, 1,  

Infection & Microbiome ⓘ

Sepsis↓, 1,  
Total Targets: 65

Scientific Paper Hit Count for: eff, efficacy
69 Silver-NanoParticles
58 Magnetic Fields
43 Sulforaphane (mainly Broccoli)
40 Curcumin
35 Vitamin C (Ascorbic Acid)
32 Thymoquinone
31 Chemotherapy
28 Shikonin
27 immunotherapy
26 chitosan
25 Piperlongumine
24 Artemisinin
24 EGCG (Epigallocatechin Gallate)
23 Selenium NanoParticles
23 Selenite (Sodium)
22 Resveratrol
22 Baicalein
22 Quercetin
20 Copper and Cu NanoParticles
20 Ashwagandha(Withaferin A)
20 Berberine
19 Radiotherapy/Radiation
18 Capsaicin
18 Magnetic Field Rotating
17 Apigenin (mainly Parsley)
17 Phenylbutyrate
17 Chlorogenic acid
17 Dichloroacetate
16 diet FMD Fasting Mimicking Diet
16 Gambogic Acid
16 Bicarbonate(Sodium)
15 Selenium
15 Lycopene
14 Propolis -bee glue
14 Exercise
14 Phenethyl isothiocyanate
13 3-bromopyruvate
13 Metformin
13 Caffeic acid
12 Citric Acid
12 Betulinic acid
12 Fisetin
11 Folic Acid, Vit B9
11 Auranofin
11 borneol
11 salinomycin
11 Rosmarinic acid
10 Alpha-Lipoic-Acid
10 Melatonin
10 Luteolin
10 Atorvastatin
10 Vitamin K2
10 Silymarin (Milk Thistle) silibinin
10 diet Methionine-Restricted Diet
10 doxorubicin
10 Honokiol
10 VitK3,menadione
9 Gold NanoParticles
9 SonoDynamic Therapy UltraSound
9 Cisplatin
9 Boron
9 Vitamin D3
9 Ellagic acid
9 Carvacrol
9 Disulfiram
9 Hydrogen Gas
9 Urolithin
8 Photodynamic Therapy
8 Hyperthermia
8 Chlorophyllin
8 Chrysin
8 Plumbagin
8 Parthenolide
7 Carnosic acid
7 Piperine
7 Electrical Pulses
6 5-fluorouracil
6 Coenzyme Q10
6 Vitamin B12
6 Fenbendazole
6 Allicin (mainly Garlic)
6 Docetaxel
6 beta-glucans
6 Bifidobacterium
6 Celastrol
6 Choline
6 HydroxyCitric Acid
6 Spermidine
6 Juglone
5 Astragalus
5 chemodynamic therapy
5 Akkermansia
5 Bevacizumab (brand Avastin)
5 Ascorbyl Palmitate
5 Astaxanthin
5 Berbamine
5 beta-carotene(VitA)
5 Bortezomib
5 Boswellia (frankincense)
5 Thymol-Thymus vulgaris
5 diet Plant based
5 MCToil
5 Magnolol
5 Moringa oleifera
4 2-DeoxyGlucose
4 almonertinib
4 Andrographis
4 Gemcitabine (Gemzar)
4 Aspirin -acetylsalicylic acid
4 Dipyridamole
4 Butyrate
4 capecitabine
4 Cat’s Claw
4 Cannabidiol
4 diet Short Term Fasting
4 Propyl gallate
4 Pterostilbene
4 Sulfasalazine
4 Whole Body Vibration
3 cetuximab
3 Anthocyanins
3 Anti-oxidants
3 Aloe anthraquinones
3 Biochanin A
3 bempedoic acid
3 Lutein
3 Zeaxanthin
3 Bufalin/Huachansu
3 temozolomide
3 hydroxychloroquine
3 Chocolate
3 Calorie Restriction Mimetics
3 erastin
3 Ginseng
3 Lecithin
3 nicotinamide adenine dinucleotide
3 Naringin
3 Radio Frequency
3 Taurine
3 Vitamin B1/Thiamine
2 5-Aminolevulinic acid
2 Glucose
2 Zinc
2 Aromatherapy
2 Sorafenib (brand name Nexavar)
2 Arsenic trioxide
2 Baicalin
2 brusatol
2 Caffeic Acid Phenethyl Ester (CAPE)
2 Caffeine
2 Calcium
2 carboplatin
2 Celecoxib
2 Oxygen, Hyperbaric
2 Emodin
2 ferumoxytol
2 Kaempferol
2 Genistein (soy isoflavone)
2 γ-linolenic acid (Borage Oil)
2 Orlistat
2 Potassium
2 Methylene blue
2 metronomic chemo
2 Methylsulfonylmethane
2 Mushroom Lion’s Mane
2 Niclosamide (Niclocide)
2 Nimbolide
2 Phosphatidylserine
2 Aflavin-3,3′-digallate
1 Serotonin, 5-hydroxytryptamine
1 dietMediterranean
1 EMF
1 Anzaroot, Astragalus fasciculifolius Bioss
1 Trichostatin A
1 wortmannin
1 Resiquimod
1 Ajoene (compound of Garlic)
1 Acetyl-l-carnitine
1 Amodiaquine
1 Vitamin A, Retinoic Acid
1 Trastuzumab
1 D-limonene
1 Huperzine A/Huperzia serrata
1 probiotics
1 Brucea javanica
1 Bacopa monnieri
1 Bromelain
1 Bruteridin(bergamot juice)
1 Rutin
1 urea
1 Carnosine
1 Cannabichromene
1 Beta‐Lapachone
1 Cinnamon
1 Camptothecin
1 irinotecan
1 Black phosphorus
1 Dichloroacetophenone(2,2-)
1 Date Fruit Extract
1 diet Fermented Foods
1 diet Ketogenic
1 PXD, phenoxodiol
1 Ferulic acid
1 Vitamin E
1 flavonoids
1 Flickering Light Stimulation
1 verapamil
1 Garcinol
1 tamoxifen
1 Hydroxycinnamic-acid
1 HydroxyTyrosol
1 itraconazole
1 Laetrile B17 Amygdalin
1 lambertianic acid
1 Docosahexaenoic Acid
1 Matrine
1 Methyl Jasmonate
1 methotrexate
1 Magnesium
1 Methylglyoxal
1 Mushroom Reishi
1 Myricetin
1 Oleocanthal
1 Peppermint
1 sericin
1 Paclitaxel
1 Psoralidin
1 enzalutamide
1 Oxaliplatin
1 Scoulerine
1 polyethylene glycol
1 acetaminophen
1 Formononetin
1 acetazolamide
1 Iron
1 Squalene
1 Glutathione
1 statins
1 Sutherlandioside D
1 triptolide
1 Tumor Treating Fields
1 Ursolic acid
1 Vitamin B3,Niacin
1 Vitamin B5,Pantothenic Acid
1 Vitamin B6,pyridoxine
1 Wogonin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:961  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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