| Source: |
| Type: type of cell death |
| Situation in which a cell actively pursues a course toward death upon receiving certain stimuli. Cancer is one of the scenarios where too little apoptosis occurs, resulting in malignant cells that will not die. |
| 9092- | CV, | I3C, | Anticancer and Antimicrobial Activity of Chlorella vulgaris BA02 Algae Extract Containing Indole-3-Acetic Acid |
| - | in-vitro, | BC, | MCF7 | - | in-vitro, | BC, | ZR-75-1 | - | in-vitro, | BC, | MDA-MB-231 |
| 9093- | CV, | Microalga Chlorella sp. extract induced apoptotic cell death of cholangiocarcinoma via AKT/mTOR signaling pathway |
| - | in-vitro, | Lung, | A549 | - | in-vitro, | Cerv, | HeLa | - | in-vitro, | BC, | MCF7 | - | in-vitro, | Liver, | HUH7 | - | in-vitro, | CCA, | KKU-100 |
| 9094- | CV, | Chlorella vulgaris Induces Apoptosis of Human Non-Small Cell Lung Carcinoma (NSCLC) Cells |
| - | in-vitro, | Lung, | A549 | - | in-vitro, | Lung, | H460 |
| 9037- | CV, | SP, | Chlorella and Arthrospira (Spirulina) as Multi-Pathway Biological Response Modulators: Molecular Mechanisms, Signaling Pathways and Clinical Evidence |
| - | Review, | Nor, | NA |
| 6249- | Cyc, | Cyclopamine tartrate, an inhibitor of Hedgehog signaling, strongly interferes with mitochondrial function and suppresses aerobic respiration in lung cancer cells |
| - | in-vitro, | NSCLC, | A549 | - | in-vitro, | NSCLC, | H1299 |
| 6247- | Cyc, | Sonic Hedgehog Pathway Contributes to Gastric Cancer Cell Growth and Proliferation |
| - | vitro+vivo, | GC, | MKN45 |
| 6248- | Cyc, | The Hedgehog Inhibitor Cyclopamine Reduces β-Catenin-Tcf Transcriptional Activity, Induces E-Cadherin Expression, and Reduces Invasion in Colorectal Cancer Cells |
| - | in-vitro, | CRC, | NA |
| 7442- | CYN, | Cynaropicrin induces the apoptosis of colorectal cancer cells by elevating reactive oxygen species and activating the JNK/p38 MAPK |
| - | in-vitro, | CRC, | HCT116 |
| 7451- | CYN, | Inhibitory effects of cynaropicrin on human melanoma progression by targeting MAPK, NF‐κB, and Nrf‐2 signaling pathways in vitro |
| - | in-vitro, | Melanoma, | A375 |
| - | in-vitro, | Lung, | A549 | - | in-vitro, | Nor, | BEAS-2B |
| 7449- | CYN, | Cytotoxic and pro-apoptotic activities of cynaropicrin, a sesquiterpene lactone, on the viability of leukocyte cancer cell lines |
| - | in-vitro, | lymphoma, | U937 | - | in-vitro, | AML, | Jurkat |
| 7446- | CYN, | Promotion of HeLa cells apoptosis by cynaropicrin involving inhibition of thioredoxin reductase and induction of oxidative stress |
| - | in-vitro, | Cerv, | HeLa |
| 7444- | CYN, | The Sesquiterpene Lactone Cynaropicrin Manifests Strong Cytotoxicity in Glioblastoma Cells U-87 MG by Induction of Oxidative Stress |
| - | in-vitro, | GBM, | U87MG |
| 7443- | CYN, | Cynaropicrin, a sesquiterpene lactone, triggers apoptotic cell death in triple negative breast cancer cells |
| - | in-vitro, | BC, | MDA-MB-231 | - | in-vitro, | BC, | MCF7 |
| 7440- | CYN, | Suppression of endoplasmic reticulum stress-dependent autophagy enhances cynaropicrin-induced apoptosis via attenuation of the P62/Keap1/Nrf2 pathways in neuroblastoma |
| - | vitro+vivo, | neuroblastoma, | NA |
| 6686- | DAP, | Lactoferrin-encapsulated dichloroacetophenone (DAP) nanoparticles enhance drug delivery and anti-tumor efficacy in prostate cancer |
| - | in-vivo, | Pca, | NA |
| 6684- | DAP, | GB, | Pharmacological synergism of 2,2-dichloroacetophenone and EGFR-TKi to overcome TKi-induced resistance in NSCLC cells |
| - | vitro+vivo, | NSCLC, | H1975 |
| 6685- | DAP, | Anticancer effects of some novel dichloroacetophenones through the inhibition of pyruvate dehydrogenase kinase 1 |
| - | in-vitro, | Lung, | H1975 |
| 1871- | DAP, | Targeting PDK1 with dichloroacetophenone to inhibit acute myeloid leukemia (AML) cell growth |
| - | in-vitro, | AML, | U937 | - | in-vivo, | AML, | NA |
| 6683- | DCA, | Dichloroacetate for Cancer Treatment: Some Facts and Many Doubts |
| - | Review, | Var, | NA |
| 6682- | DCA, | QC, | Dichloroacetate and Quercetin Prevent Cell Proliferation, Induce Cell Death and Slow Tumor Growth in a Mouse Model of HPV-Positive Head and Neck Cancer |
| - | in-vivo, | HNSCC, | MEER |
| 6681- | DCA, | Dichloroacetate (DCA) in Cancer Care |
| - | Review, | Var, | NA |
| 1889- | DCA, | A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth |
| - | Review, | Var, | NA |
| 1874- | DCA, | Dichloroacetate induces apoptosis of epithelial ovarian cancer cells through a mechanism involving modulation of oxidative stress |
| - | in-vitro, | Ovarian, | SKOV3 | - | in-vitro, | Ovarian, | MDAH-2774 |
| 1873- | DCA, | Dual-targeting of aberrant glucose metabolism in glioblastoma |
| - | in-vitro, | GBM, | U87MG | - | in-vitro, | GBM, | U251 |
| 1870- | DCA, | Rad, | Dichloroacetate (DCA) sensitizes both wild-type and over expressing Bcl-2 prostate cancer cells in vitro to radiation |
| - | in-vitro, | Pca, | PC3 |
| 1868- | DCA, | MET, | Long-term stabilization of stage 4 colon cancer using sodium dichloroacetate therapy |
| - | Case Report, | CRC, | NA |
| 5194- | DCA, | Metabolic modulation of glioblastoma with dichloroacetate |
| - | vitro+vivo, | GBM, | NA |
| 5196- | DCA, | Dichloroacetate induces apoptosis in endometrial cancer cells |
| - | in-vitro, | Var, | NA |
| 4901- | DCA, | Sal, | Dichloroacetate and Salinomycin as Therapeutic Agents in Cancer |
| - | Review, | NSCLC, | NA |
| 1442- | Deg, | Deguelin, a novel anti-tumorigenic agent targeting apoptosis, cell cycle arrest and anti-angiogenesis for cancer chemoprevention |
| - | Review, | Var, | NA |
| 6675- | Deg, | Deguelin inhibits growth of breast cancer cells by modulating the expression of key members of the Wnt signaling pathway |
| - | in-vitro, | BC, | MCF7 | - | in-vitro, | BC, | BT474 | - | in-vitro, | BC, | T47D | - | in-vitro, | BC, | MDA-MB-231 |
| 6676- | Deg, | Deguelin’s Anticancer Bioactivity: Challenges and Opportunities in Medicinal Chemistry |
| - | Review, | Var, | NA |
| 6674- | Deg, | Deguelin induces the apoptosis of lung cancer cells through regulating a ROS driven Akt pathway |
| - | in-vitro, | Lung, | H1975 |
| 6672- | Deg, | Deguelin, an Akt inhibitor, down-regulates NF-κB signaling and induces apoptosis in colon cancer cells and inhibits tumor growth in mice |
| - | vitro+vivo, | CRC, | COLO205 | - | in-vitro, | CRC, | HCT116 |
| 6677- | Deg, | Deguelin inhibits non-small cell lung cancer via down-regulating Hexokinases II-mediated glycolysis |
| - | in-vitro, | NSCLC, | NA |
| 19- | Deg, | Deguelin inhibits proliferation and migration of human pancreatic cancer cells in vitro targeting hedgehog pathway |
| - | in-vitro, | PC, | Bxpc-3 | - | in-vitro, | PC, | PANC1 |
| 6701- | DFC, | Intracellular pH and calcium signaling as molecular targets of diclofenac-induced apoptosis against colon cancer |
| - | in-vivo, | Colon, | NA |
| 6695- | DFC, | Inhibition of lactate dehydrogenase A by diclofenac sodium induces apoptosis in HeLa cells through activation of AMPK |
| - | in-vitro, | Cerv, | HeLa |
| 6692- | DFC, | Diclofenac Inhibits Tumor Growth in a Murine Model of Pancreatic Cancer by Modulation of VEGF Levels and Arginase Activity |
| - | in-vivo, | PC, | Panc02 |
| 6691- | DFC, | Diclofenac impairs the proliferation and glucose metabolism of triple-negative breast cancer cells by targeting the c-Myc pathway |
| - | in-vitro, | Melanoma, | NA | - | in-vitro, | BC, | MDA-MB-231 | - | in-vitro, | BC, | HCC1937 | - | in-vitro, | BC, | MCF7 |
| 6689- | DFC, | Diclofenac-Induced Apoptosis in the Neuroblastoma Cell Line SH-SY5Y: Possible Involvement of the Mitochondrial Superoxide Dismutase |
| - | in-vitro, | neuroblastoma, | SH-SY5Y |
| 4454- | DFE, | Cytostatic and Anti-tumor Potential of Ajwa Date Pulp against Human Hepatocellular Carcinoma HepG2 Cells |
| - | in-vitro, | Liver, | HepG2 |
| 4455- | DFE, | Ajwa Date (Phoenix dactylifera L.) Extract Inhibits Human Breast Adenocarcinoma (MCF7) Cells In Vitro by Inducing Apoptosis and Cell Cycle Arrest |
| - | in-vitro, | BC, | MCF7 | - | in-vitro, | Nor, | 3T3 |
| 4456- | DFE, | Induction of apoptosis and cell cycle arrest by ethyl acetate fraction of Phoenix dactylifera L. (Ajwa dates) in prostate cancer cells |
| - | in-vitro, | Pca, | PC3 |
| 1858- | dietFMD, | Chemo, | Effect of short-term fasting on the cisplatin activity in human oral squamous cell carcinoma cell line HN5 and chemotherapy side effects |
| - | in-vitro, | HNSCC, | HN5 |
| 1861- | dietFMD, | Chemo, | Fasting induces anti-Warburg effect that increases respiration but reduces ATP-synthesis to promote apoptosis in colon cancer models |
| - | in-vitro, | Colon, | CT26 | - | in-vivo, | NA, | NA |
| 1843- | dietFMD, | BTZ, | Cyclic Fasting–Mimicking Diet Plus Bortezomib and Rituximab Is an Effective Treatment for Chronic Lymphocytic Leukemia |
| - | in-vivo, | CLL, | NA |
| 5190- | dietMet, | Methionine restriction activates the integrated stress response in triple-negative breast cancer cells by a GCN2- and PERK-independent mechanism |
| - | in-vitro, | BC, | MDA-MB-231 | - | in-vitro, | BC, | MDA-MB-468 |
| 5070- | dietSTF, | A review of fasting effects on the response of cancer to chemotherapy |
| - | Review, | Var, | NA |
Query results interpretion may depend on "conditions" listed in the research papers. Such Conditions may include : -low or high Dose -format for product, such as nano of lipid formations -different cell line effects -synergies with other products -if effect was for normal or cancerous cells
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