MMP Cancer Research Results

MMP, ΔΨm, mitochondrial membrane potential: Click to Expand ⟱
Source:
Type:
Destruction of mitochondrial transmembrane potential, which is widely regarded as one of the earliest events in the process of cell apoptosis.
Mitochondria are organelles within eukaryotic cells that produce adenosine triphosphate (ATP), the main energy molecule used by the cell. For this reason, the mitochondrion is sometimes referred to as “the powerhouse of the cell”.
Mitochondria produce ATP through process of cellular respiration—specifically, aerobic respiration, which requires oxygen. The citric acid cycle, or Krebs cycle, takes place in the mitochondria.
The mitochondrial membrane potential is widely used in assessing mitochondrial function as it relates to the mitochondrial capacity of ATP generation by oxidative phosphorylation. The mitochondrial membrane potential is a reliable indicator of mitochondrial health.
In cancer cells, ΔΨm is often decreased, which can lead to changes in cellular metabolism, increased glycolysis, increased reactive oxygen species (ROS) production, and altered cell death pathways.

The membrane of malignant mitochondria is hyperpolarized (−220 mV) in comparison to their healthy counterparts (−160 mV), which facilitates the penetration of positively charged molecules to the cancer cells mitochondria.
The MMP is a critical indicator of mitochondrial function, directly reflecting the organelle's capacity to generate ATP through oxidative phosphorylation.


Scientific Papers found: Click to Expand⟱
5125- Sal,    Salinomycin induced ROS results in abortive autophagy and leads to regulated necrosis in glioblastoma
- in-vitro, GBM, NA
ER Stress↑, UPR↑, autoF↓, lysosome↝, ROS↑, lipid-P↑, CSCs↓, necrosis↑, ATP↓, MMP↓, MOMP↑, DNAdam↑, AIF↑, lysoMP↑, MitoP↑, Ca+2↑,
1208- SANG,    Sanguinarine induces apoptosis in osteosarcoma by attenuating the binding of STAT3 to the single-stranded DNA-binding protein 1 (SSBP1) promoter region
- in-vitro, OS, NA
SSBP1↑, mtDam↑, Apoptosis↑, JAK↓, STAT3↓, PI3k/Akt/mTOR↓, ROS↑, MMP↓,
6449- SAO,    Skin cancer chemoprevention by α-santalol
- Review, Melanoma, A431
*chemoPv↑, Apoptosis↑, Casp↑, MMP↓, Cyt‑c↑, TumCCA↑, TumCG↓,
5139- SAS,    Sulfasalazine induces ferroptosis in osteosarcomas by regulating Nrf2/SLC7A11/GPX4 signaling axis
- in-vitro, OS, MG63 - in-vitro, OS, U2OS
*Inflam↓, TumCP↓, TumCMig↓, Apoptosis↑, Ferroptosis↑, Iron↑, MDA↑, ROS↑, GSH↓, SOD↓, MMP↓, NRF2↓, xCT/SLC7A11↓, GPx4↓, FTH1↓,
2549- SDT,    Landscape of Cellular Bioeffects Triggered by Ultrasound-Induced Sonoporation
- Review, Var, NA
sonoP↑, tumCV↓, MMP↓, ROS↑, Ca+2↑, eff↝, eff↑, selectivity↑, Half-Life↝, Dose↝, P-gp/ABCB1↓, ER Stress↑, other↑,
4486- Se,  Chit,    Selenium-Modified Chitosan Induces HepG2 Cell Apoptosis and Differential Protein Analysis
- in-vitro, Liver, HepG2
Apoptosis↑, TumCCA↑, MMP↓, Bcl-2↓, BAX↑, cl‑Casp9↑, cl‑Casp3↑, Risk↓, *BioAv↑, *toxicity↑, TumCG↓, AntiTum↑, ROS↑, Cyt‑c↑, Fas↑, FasL↑, FADD↑,
4484- Se,  Chit,  PEG,    Anti-cancer potential of selenium-chitosan-polyethylene glycol-carvacrol nanocomposites in multiple myeloma U266 cells
- in-vitro, Melanoma, U266
tumCV↓, selectivity↑, ROS↑, MMP↓, Apoptosis↑, BAX↑, Casp3↑, Casp9↑, Bcl-2↓,
4714- Se,  SSE,  SeNPs,    Selenium in cancer management: exploring the therapeutic potential
- Review, Var, NA
Risk↓, *BioAv↑, eff↝, *ROS↓, MMP↓, ROS↑, P53↑, *toxicity↓, TumCP↓, Casp↑, Apoptosis↑,
4471- SeNPs,    Green synthesis of selenium nanoparticles with extract of hawthorn fruit induced HepG2 cells apoptosis
- in-vitro, Liver, HepG2
eff↑, ROS↑, MMP↓, Casp9↑, Bcl-2↓, selectivity↑, Apoptosis↑,
4469- SeNPs,    Selenium Nanoparticles in Cancer Therapy: Unveiling Cytotoxic Mechanisms and Therapeutic Potential
- Review, Var, NA
antiOx↑, selectivity↑, eff↑, AntiCan↑, Apoptosis↑, ROS↑, MMP↓, Casp3↑, Casp9↑, AntiTum↑, TumCG↓, TumMeta↓, angioG↓, Cyt‑c↑, DNAdam↑, RadioS↑, BBB↑, *toxicity↓, ChemoSen↑,
4449- SeNPs,    PEG-nanolized ultrasmall selenium nanoparticles overcome drug resistance in hepatocellular carcinoma HepG2 cells through induction of mitochondria dysfunction
- in-vitro, Liver, HepG2
MMP↓, selectivity↑, Apoptosis↑, ROS↑,
4453- SeNPs,    Selenium Nanoparticles: Green Synthesis and Biomedical Application
- Review, Var, NA
*toxicity↓, *Bacteria↓, ROS↑, MMP↓, ER Stress↑, P53↑, Apoptosis↑, Casp9↑, DNAdam↑, TumCCA↑, eff↑, Catalase↓, SOD↓, GSH↓, selectivity↓, selectivity↑, PCNA↓, eff↑, *ALAT↓, *AST↓, *ALP↓, *creat↓, *Inflam↓, *toxicity↓, selectivity↑,
9281- SES, SSM,  LIGs,    A comprehensive review on the anti-cancer properties of sesame lignans: chemical composition, molecular mechanisms and prospects
- Review, Var, NA
Ingr↝, ChemoSen↑, *Sleep↑, *antiOx↑, *GPx↑, *GSR↑, *GSH↑, *MDA↓, selectivity↑, TumCCA↑, cycD1/CCND1↓, CDK2↓, P53↑, COX2/PTGS2↓, TumCP↓, Apoptosis↑, DNAdam↑, cl‑Casp3↑, NF-kB↓, ROS↑, MMP↓, VEGF↓, MMP9↓, Hif1a↓,
9188- SFN,    Broccoli-Derived Sulforaphane and Chemoprevention of Prostate Cancer: From Bench to Bedside
- Review, Pca, NA
chemoPv↑, antiNeop↑, Risk↓, Ingr↝, NRF2↑, NQO1↑, ROS↑, MMP↓, Cyt‑c↑, Apoptosis↑, STAT3↓, Bcl-2↓, cycD1/CCND1↓, survivin↓, HDAC↓, DNMTs↓, HDAC3↓, HDAC6↓, Akt↓, TumCG↓, BioAv↑, Half-Life↝, PSA↓, PSADT↑,
2167- SFN,    The dietary isothiocyanate sulforaphane targets pathways of apoptosis, cell cycle arrest, and oxidative stress in human pancreatic cancer cells and inhibits tumor growth in severe combined immunodeficient mice
- in-vitro, PC, MIA PaCa-2 - in-vitro, PC, PANC1
Casp8↑, MMP↓, Casp3↑, Apoptosis↑, GSH↓, GSH↑,
2448- SFN,    Sulforaphane and bladder cancer: a potential novel antitumor compound
- Review, Bladder, NA
Apoptosis↑, TumCG↓, TumCI↓, TumMeta↓, glucoNG↓, ChemoSen↑, TumCCA↑, Casp3↑, Casp7↑, cl‑PARP↑, survivin↓, EGFR↓, HER2/EBBR2↓, ATP↓, Glycolysis↓, mt-OXPHOS↓, AKT1↓, HK2↓, Hif1a↓, ROS↑, NRF2↑, EMT↓, COX2/PTGS2↓, MMP2↓, MMP9↓, Zeb1↓, Snail↓, HDAC↓, HATs↓, MMP↓, Cyt‑c↓, Shh↓, Smo↓, Gli1↓, BioAv↝, BioAv↝, Dose↝,
1459- SFN,  AF,    Auranofin Enhances Sulforaphane-Mediated Apoptosis in Hepatocellular Carcinoma Hep3B Cells through Inactivation of the PI3K/Akt Signaling Pathway
- in-vitro, Liver, Hep3B - in-vitro, Liver, HepG2
eff↑, TumCCA↑, Apoptosis↑, MMP↓, BAX↑, cl‑PARP↑, Casp3↑, Casp8↑, Casp9↑, ROS↑, eff↓, PI3K↓, Akt↓, TrxR↓, BAX↑, Bcl-2∅,
1471- SFN,    ROS-mediated activation of AMPK plays a critical role in sulforaphane-induced apoptosis and mitotic arrest in AGS human gastric cancer cells
- in-vitro, GC, AGS
TumCP↓, Apoptosis↑, TumCCA↑, CycB/CCNB1↑, P21↑, p‑H3↑, p‑AMPK↑, eff↓, MMP↓, Cyt‑c↑, ROS↑, eff↓,
1469- SFN,    Sulforaphane enhances the therapeutic potential of TRAIL in prostate cancer orthotopic model through regulation of apoptosis, metastasis, and angiogenesis
- in-vitro, Pca, PC3 - in-vitro, Pca, LNCaP - in-vivo, Pca, NA
Synergy↑, ROS↑, MMP↓, Casp3↑, Casp9↑, DR4↑, DR5↑, BAX↑, Bak↑, BIM↑, NOXA↑, Bcl-2↓, Bcl-xL↓, Mcl-1↓, eff↓, TumCG↓, TumCP↓, eff↑, NF-kB↓, PI3K↓, Akt↓, MEK↓, ERK↓, angioG↓, FOXO3↑,
1468- SFN,    Cellular responses to dietary cancer chemopreventive agent D,L-sulforaphane in human prostate cancer cells are initiated by mitochondrial reactive oxygen species
- in-vitro, Pca, LNCaP - in-vitro, Pca, PC3
ROS↑, DNAdam↑, MMP↓, Cyt‑c↑, TumCCA↑,
1467- SFN,    Sulforaphane generates reactive oxygen species leading to mitochondrial perturbation for apoptosis in human leukemia U937 cells
- in-vitro, AML, U937
Apoptosis↑, ROS↑, MMP↓, Casp3↑, Bcl-2↓, eff↓,
1466- SFN,    Sulforaphane inhibits thyroid cancer cell growth and invasiveness through the reactive oxygen species-dependent pathway
- vitro+vivo, Thyroid, FTC-133
TumCP↓, TumCCA↑, Apoptosis↑, TumCMig↓, TumCI↓, EMT↓, Slug↓, Twist↓, MMP2↓, MMP9↓, TumCG↓, p‑Akt↓, P21↑, ERK↑, p38↑, ROS↑, *toxicity∅, MMP↓, eff↓,
1465- SFN,    TRAIL attenuates sulforaphane-mediated Nrf2 and sustains ROS generation, leading to apoptosis of TRAIL-resistant human bladder cancer cells
- in-vitro, Bladder, NA
Synergy↑, Apoptosis↑, Casp↑, MMP↓, BID↑, DR5↑, ROS↑, NRF2↑, eff↑, eff↓,
1458- SFN,    Sulforaphane Impact on Reactive Oxygen Species (ROS) in Bladder Carcinoma
- Review, Bladder, NA
HDAC↓, eff↓, TumW↓, TumW↓, angioG↓, *toxicity↓, GutMicro↝, AntiCan↑, ROS↑, MMP↓, Cyt‑c↑, Bax:Bcl2↑, Casp3↑, Casp9↑, Casp8∅, cl‑PARP↑, TRAIL↑, DR5↑, eff↓, NRF2↑, ER Stress↑, COX2/PTGS2↓, EGFR↓, HER2/EBBR2↓, ChemoSen↑, NF-kB↓, TumCCA?, p‑Akt↓, p‑mTOR↓, p70S6↓, p19↑, P21↑, CD44↓, CSCs↓,
1456- SFN,    Sulforaphane regulates cell proliferation and induces apoptotic cell death mediated by ROS-cell cycle arrest in pancreatic cancer cells
- in-vitro, PC, MIA PaCa-2 - in-vitro, PC, PANC1
tumCV↓, TumCP↓, cl‑PARP↑, cl‑Casp3↑, TumCCA↑, ROS↑, MMP↓, γH2AX↑, eff↓, *toxicity↓,
1474- SFN,    Sulforaphane induces p53‑deficient SW480 cell apoptosis via the ROS‑MAPK signaling pathway
- in-vitro, Colon, SW480
TumCG↓, Apoptosis↑, MMP↓, Bax:Bcl2↑, Casp3↑, Casp7↑, Casp9↑, ROS↑, e-ERK↑, p38↑, P53∅, eff↓, ChemoSen↑,
1482- SFN,    Sulforaphane induces apoptosis in T24 human urinary bladder cancer cells through a reactive oxygen species-mediated mitochondrial pathway: the involvement of endoplasmic reticulum stress and the Nrf2 signaling pathway
- in-vitro, Bladder, T24/HTB-9
tumCV↓, Apoptosis↑, Cyt‑c↑, Bax:Bcl2↑, Casp9↑, Casp3↑, Casp8∅, cl‑PARP↑, ROS↑, MMP↓, eff↓, ER Stress↑, p‑NRF2↑, HO-1↑,
1723- SFN,    Sulforaphane as a potential remedy against cancer: Comprehensive mechanistic review
- Review, Var, NA
*NRF2↑, ROS↑, MMP↓, Cyt‑c↑, cl‑PARP↑, Apoptosis↑, AMPK↑, GSH↓,
3309- SIL,    Silymarin as a Natural Antioxidant: An Overview of the Current Evidence and Perspectives
- Review, Nor, NA
*ROS↓, *IronCh↑, *MMP↑, *NRF2↑, *Inflam↓, *hepatoP↑, *HSPs↑, *Trx↑, *SIRT2↑, *GSH↑, *ROS↑, *NADPH↓, *iNOS↓, *NF-kB↓, *BioAv↓, *Dose↝, *BioAv↑,
3299- SIL,    Silymarin Effect on Mitophagy Pathway in the Human Colon Cancer HT-29 Cells
- in-vitro, Colon, HT29
tumCV↓, MMP↓, ROS↑, selectivity↑,
3298- SIL,    Silibinin, a natural flavonoid, induces autophagy via ROS-dependent mitochondrial dysfunction and loss of ATP involving BNIP3 in human MCF7 breast cancer cells
- in-vitro, BC, MCF7
LC3II↑, Beclin-1/ATG6↑, Bcl-2↓, ROS↑, MMP↓, ATP↓, eff↓, BNIP3?, TumAuto↑, eff↑,
3297- SIL,  Rad,    Studies on radiation sensitization efficacy by silymarin in colon carcinoma cells
- in-vitro, CRC, HCT15 - in-vitro, CRC, RKO
TumCP↓, RadioS↑, TumCCA↑, DNAdam↓, MMP↓, ROS↓, *radioP↑,
3290- SIL,    A review of therapeutic potentials of milk thistle (Silybum marianum L.) and its main constituent, silymarin, on cancer, and their related patents
- Analysis, Var, NA
hepatoP↑, chemoP↑, *lipid-P↓, *antiOx↑, tumCV↓, TumCMig↓, Apoptosis↑, ROS↑, GSH↓, Bcl-2↓, survivin↓, cycD1/CCND1↓, NOTCH1↓, BAX↑, NF-kB↓, COX2/PTGS2↓, LOX1↓, iNOS↓, TNF-α↓, IL1↓, Inflam↓, *toxicity↓, CXCR4↓, EGFR↓, ERK↓, MMP↓, Cyt‑c↑, TumCCA↑, RB1↑, P53↑, P21↑, p27/CDKN1B↑, cycE/CCNE↓, CDK4↓, p‑pRB↓, Hif1a↓, cMyc↓, IL1β↓, IFN-γ↓, PCNA↓, PSA↓, CYP1A1↓,
3288- SIL,    Silymarin in cancer therapy: Mechanisms of action, protective roles in chemotherapy-induced toxicity, and nanoformulations
- Review, Var, NA
Inflam↓, lipid-P↓, TumMeta↓, angioG↓, chemoP↑, EMT↓, HDAC↓, HATs↑, MMPs↓, uPA↓, PI3K↓, Akt↓, VEGF↓, CD31/PECAM-1↓, Hif1a↓, VEGFR2/KDR/Flk1↓, Raf↓, MEK↓, ERK↓, BIM↓, BAX↑, Bcl-2↓, Bcl-xL↓, Casp↑, MAPK↓, P53↑, LC3II↑, mTOR↓, YAP/TEAD↓, *BioAv↓, MMP↓, Cyt‑c↑, PCNA↓, cMyc↓, cycD1/CCND1↓, β-catenin/ZEB1↓, survivin↓, APAF1↑, Casp3↑, MDSCs↓, IL10↓, IL2↑, IFN-γ↑, hepatoP↑, cardioP↑, GSH↑, neuroP↑,
3282- SIL,    Role of Silymarin in Cancer Treatment: Facts, Hypotheses, and Questions
- Review, Var, NA
hepatoP↑, AntiCan↑, TumCMig↓, Hif1a↓, selectivity↑, toxicity∅, *antiOx↑, *Inflam↓, TumCCA↑, P21↑, CDK4↓, NF-kB↓, ERK↓, PSA↓, TumCG↓, p27/CDKN1B↑, COX2/PTGS2↓, IL1↓, VEGF↓, IGFBP3↑, AR↓, STAT3↓, Telomerase↓, Cyt‑c↑, Casp↑, eff↝, HDAC↓, HATs↑, Zeb1↓, E-cadherin↑, miR-203↑, NHE1↓, MMP2↓, MMP9↓, PGE2↓, Vim↓, Wnt↓, angioG↓, VEGF↓, *TIMP1↓, EMT↓, TGF-β↓, CD44↓, EGFR↓, PDGF↓, *IL8↓, SREBP1/SREBF1↓, MMP↓, ATP↓, uPA↓, PD-L1↓, NOTCH↓, *SIRT1↑, SIRT1↓, CA↓, Ca+2↑, chemoP↑, cardioP↑, Dose↝, Half-Life↝, BioAv↓, BioAv↓, BioAv↓, toxicity↝, Half-Life↓, ROS↓, FAK↓,
3319- SIL,    Silymarin and neurodegenerative diseases: Therapeutic potential and basic molecular mechanisms
- Review, AD, NA - Review, Park, NA - Review, Stroke, NA
*neuroP↑, *ROS↓, *Inflam↓, *Apoptosis↓, *BBB?, *tau↓, *NF-kB↓, *IL1β↓, *TNF-α↓, *IL4↓, *MAPK↓, *memory↑, *cognitive↑, *Aβ↓, *ROS↓, *lipid-P↓, *GSH↑, *MDA↓, *SOD↑, *Catalase↑, *AChE↓, *BChE↓, *p‑ERK↓, *p‑JNK↓, *p‑p38↓, *GutMicro↑, *COX2/PTGS2↓, *iNOS↓, *TLR4↓, *neuroP↑, *Strength↑, *AMPK↑, *MMP↑, *necrosis↓, *NRF2↑, *HO-1↑,
3646- SIL,    "Silymarin", a promising pharmacological agent for treatment of diseases
- Review, Var, NA
*P-gp/ABCB1↓, *Inflam↓, *hepatoP↑, *antiOx↑, *GSH↑, *BioAv↑, *SOD↑, *IFN-γ↓, *IL4↓, *IL10↓, *Half-Life↓, *TNF-α↓, *ALAT↓, *AST↓, Akt↓, chemoP↑, β-catenin/ZEB1↓, TumCP↓, MMP↓, Cyt‑c↑, *RenoP↑, *BBB↑,
2410- SIL,    Autophagy activated by silibinin contributes to glioma cell death via induction of oxidative stress-mediated BNIP3-dependent nuclear translocation of AIF
- in-vitro, GBM, U87MG - in-vitro, GBM, U251 - in-vivo, NA, NA
TumAuto↑, ATP↓, Glycolysis↓, H2O2↑, P53↑, GSH↓, xCT/SLC7A11↓, BNIP3↝, MMP↑, mt-ROS↑, mtDam↑, HK2↓, PFKP↓, PKM2↓, TumCG↓,
2416- SK,    Shikonin induces cell death by inhibiting glycolysis in human testicular cancer I-10 and seminoma TCAM-2 cells
- in-vitro, Testi, TCAM-2
MMP↓, ROS↑, lactateProd↓, Bcl-2↓, cl‑Casp3↓, PKM2↓, GLUT1↓, HK2↓, LC3B↑,
2230- SK,    Shikonin induces ROS-based mitochondria-mediated apoptosis in colon cancer
- in-vitro, CRC, HCT116 - in-vivo, NA, NA
TumCG↓, Bcl-2↓, ROS↑, Bcl-xL↓, MMP↓, Casp↑, selectivity↑, cycD1/CCND1↓, TumCCA↑, eff↓,
2231- SK,    Shikonin Exerts Cytotoxic Effects in Human Colon Cancers by Inducing Apoptotic Cell Death via the Endoplasmic Reticulum and Mitochondria-Mediated Pathways
- in-vitro, CRC, SNU-407
Apoptosis↑, ER Stress↑, PERK↑, eIF2α↑, CHOP/DDIT3↑, mt-Ca+2↑, MMP↓, Bcl-2↓, Casp3↑, Casp9↑, ERK↑, JNK↑, p38↓,
2190- SK,    Shikonin exerts antitumor activity by causing mitochondrial dysfunction in hepatocellular carcinoma through PKM2-AMPK-PGC1α signaling pathway
- in-vitro, HCC, HCCLM3
TumCP↓, TumCMig↓, TumCI↓, Apoptosis↑, MMP↓, ROS↑, OCR↓, ATP↓, PKM2↓,
2188- SK,    Molecular mechanism of shikonin inhibiting tumor growth and potential application in cancer treatment
- Review, Var, NA
ROS↑, EGFR↓, PI3K↓, Akt↓, angioG↓, Apoptosis↑, Necroptosis↑, GSH↓, Ca+2↓, MMP↓, ERK↓, p38↑, proCasp3↑, eff↓, VEGF↓, FOXO3↑, EGR1↑, SIRT1↑, RIP1↑, RIP3↑, BioAv↓, NF-kB↓, Half-Life↓,
2227- SK,    Shikonin induces mitochondria-mediated apoptosis and enhances chemotherapeutic sensitivity of gastric cancer through reactive oxygen species
- in-vitro, GC, BGC-823 - in-vitro, GC, SGC-7901 - in-vitro, Nor, GES-1
selectivity↑, TumCP↓, TumCD↑, ROS↑, MMP↓, Casp↑, Cyt‑c↑, Endon↑, AIF↑, eff↓, ChemoSen↑, TumCCA↑, GSH/GSSG↓, lipid-P↑,
2219- SK,    Shikonin induces apoptosis of HaCaT cells via the mitochondrial, Erk and Akt pathways
- in-vitro, Nor, HaCaT
*MMP↓, *ROS↑, *Casp3↑, *TumCG↓,
3045- SK,    Cutting off the fuel supply to calcium pumps in pancreatic cancer cells: role of pyruvate kinase-M2 (PKM2)
- in-vitro, PC, MIA PaCa-2
ECAR↓, Glycolysis↓, ATP↓, PKM2↓, TumCMig↓, Ca+2↑, GlucoseCon↓, lactateProd↓, MMP↓, ROS↑,
3043- SK,    Shikonin Induces Apoptosis by Inhibiting Phosphorylation of IGF-1 Receptor in Myeloma Cells.
- in-vitro, Melanoma, RPMI-8226
IGF-1↓, Apoptosis↑, TumCCA↑, MMP↓, Casp3↑, P53↑, BAX↑, Mcl-1↓, EGFR↓, Src↑, VEGFR2/KDR/Flk1↓, p‑IGF-1↓, PI3K↓, Akt↓,
3041- SK,    Promising Nanomedicines of Shikonin for Cancer Therapy
- Review, Var, NA
Glycolysis↓, TAMS↝, BioAv↓, Half-Life↝, P21↑, ERK↓, ROS↑, GSH↓, MMP↓, TrxR↓, MMP13↓, MMP2↓, MMP9↓, SIRT2↑, Hif1a↓, PKM2↓, TumCP↓, TumMeta↓, TumCI↓,
3040- SK,    Pharmacological Properties of Shikonin – A Review of Literature since 2002
- Review, Var, NA - Review, IBD, NA - Review, Stroke, NA
*Half-Life↝, *BioAv↓, *BioAv↑, *BioAv↑, *Inflam↓, *TNF-α↓, *other↑, *MPO↓, *COX2/PTGS2↓, *NF-kB↑, *STAT3↑, *antiOx↑, *ROS↓, *neuroP↑, *SOD↑, *Catalase↑, *GPx↑, *Bcl-2↑, *BAX↓, cardioP↑, AntiCan↑, NF-kB↓, ROS↑, PKM2↓, TumCCA↑, Necroptosis↑, Apoptosis↑, DNAdam↑, MMP↓, Cyt‑c↑, LDH↝,
2008- SK,  Cisplatin,    Enhancement of cisplatin-induced colon cancer cells apoptosis by shikonin, a natural inducer of ROS in vitro and in vivo
- in-vitro, CRC, HCT116 - in-vivo, NA, NA
ChemoSen↑, selectivity↑, i-ROS↑, DNAdam↑, MMP↓, TumCCA↑, eff↓, *toxicity↓,

Showing Research Papers: 701 to 750 of 814
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 814

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 5,   NA?, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 3,   antiOx↑, 10,   antiOx⇅, 1,   ARE↑, 1,   Catalase↓, 18,   Catalase↑, 4,   Ceru↓, 1,   Copper↑, 1,   CoQ10↝, 1,   ENOX2↓, 1,   Fenton↑, 4,   GCLM↓, 1,   GPx↓, 4,   GPx↑, 2,   GPx1↓, 1,   GPx4↓, 17,   GSH↓, 76,   GSH↑, 7,   i-GSH∅, 1,   mt-GSH↓, 1,   GSH/GSSG↓, 7,   GSR↓, 2,   GSR↑, 1,   GSSG↑, 1,   ox-GSSG↑, 1,   GSTs↓, 2,   GSTs↑, 2,   GSTs↝, 1,   H2O2?, 1,   H2O2↓, 1,   H2O2↑, 9,   i-H2O2↑, 1,   mt-H2O2↑, 1,   HO-1↓, 6,   HO-1↑, 10,   HO-1⇅, 1,   HO-2↓, 1,   Iron↓, 1,   Iron↑, 10,   i-Iron↑, 1,   c-Iron↑, 1,   Keap1↓, 1,   lipid-P↓, 5,   lipid-P↑, 32,   lipid-P↝, 1,   MDA↓, 2,   MDA↑, 13,   NADH↓, 5,   NOX↑, 1,   NOX4↑, 1,   NQO1↓, 1,   NQO1↑, 3,   NRF2↓, 20,   NRF2↑, 20,   NRF2⇅, 1,   NRF2↝, 1,   p‑NRF2↓, 1,   p‑NRF2↑, 1,   Prx↓, 1,   RNS↓, 1,   ROS?, 5,   ROS↓, 28,   ROS↑, 527,   ROS⇅, 9,   ROS↝, 2,   ROS∅, 4,   i-ROS?, 1,   i-ROS↓, 1,   i-ROS↑, 6,   m-ROS↑, 1,   mt-ROS↑, 16,   SOD↓, 22,   SOD↑, 2,   mt-SOD↑, 1,   SOD1↓, 1,   SOD1↑, 1,   SOD2↓, 5,   SOD2↑, 4,   TAC↓, 3,   TBARS↑, 3,   Thiols↓, 3,   Thiols↝, 1,   TKT↓, 1,   Trx↓, 5,   Trx↑, 2,   Trx1↓, 1,   Trx1↑, 1,   Trx2↓, 1,   TrxR↓, 18,   TrxR↑, 1,   TrxR1↓, 2,   xCT/SLC7A11↓, 7,  

Metal & Cofactor Biology(tgid=2) ⓘ

FTH1↓, 2,   IronCh↑, 2,   Tf↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↑, 3,   BCR↓, 1,   CDC2↓, 6,   CDC25↓, 15,   CDC25↝, 1,   compI↓, 8,   compI↑, 1,   compII↓, 2,   compII↑, 1,   compIII↓, 5,   compV↓, 1,   EGF↓, 2,   ETC↓, 18,   ETC↝, 2,   FIS1↓, 1,   HSP60/HSPD1↓, 2,   HTRA2/Omi/PARK13↑, 1,   IDH2↓, 1,   MFN2↓, 1,   mitResp↓, 9,   mitResp↑, 5,   MKK7↓, 1,   mRET↑, 1,   mtDam↓, 2,   mtDam↑, 56,   OCR↓, 20,   OCR↑, 1,   OXPHOS↓, 10,   OXPHOS↑, 4,   OXPHOS↝, 2,   OXPHOS∅, 1,   mt-OXPHOS↓, 1,   mt-OXPHOS↑, 1,   PDH↑, 2,   PDH↝, 1,   p‑PDH↓, 2,   PGC-1α↑, 1,   PHB↑, 1,   PINK1↑, 6,   SDH↓, 1,   SIRT3↓, 3,   SIRT3↑, 2,   SSBP1↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 3,   5LO↓, 1,   ACC↓, 1,   ACC↑, 2,   ACSL4↑, 1,   ALAT↓, 4,   ALAT↑, 1,   ALAT∅, 1,   ALDOA↓, 1,   AMP↑, 2,   AMPK↓, 1,   AMPK↑, 33,   p‑AMPK↑, 4,   p‑AMT/GCST/T-protein↑, 1,   ANXA7↑, 2,   ATP↓, 60,   ATP↑, 3,   ATP↝, 1,   ATP∅, 1,   e-ATP↑, 1,   BHB↑, 1,   CAIX/CA9↓, 1,   DHODH↓, 2,   ECAR↓, 3,   ECAR↝, 1,   FAO↑, 1,   FASN↓, 6,   G6PD↓, 1,   GLS↓, 1,   glucoNG↓, 1,   GlucoseCon↓, 18,   GlucoseCon↑, 1,   GlutMet↓, 1,   Glycolysis↓, 41,   GSK‐3β↓, 7,   GSK‐3β↑, 5,   p‑GSK‐3β↓, 4,   H2S↑, 1,   HK1↓, 1,   HK2↓, 29,   HMG-CoA↓, 2,   HMGCS2↑, 1,   lactateProd↓, 18,   lactateProd↑, 3,   LDHA↓, 11,   LDL↓, 4,   NAD↓, 1,   NADPH↓, 1,   NADPH↑, 3,   PCK1↓, 1,   PDK1 / PDPK1?, 2,   PDK1 / PDPK1↓, 11,   PDKs↓, 6,   PFK↓, 8,   PFKP↓, 1,   PKM2↓, 15,   PKM2↑, 1,   PKM2∅, 1,   PPP↓, 1,   SCD1↓, 2,   SIRT1↓, 13,   SIRT1↑, 4,   SIRT2↓, 1,   SIRT2↑, 1,   SLC25A1↓, 1,   SREBP1/SREBF1↓, 2,   SREBP2↓, 1,   TCA?, 1,   TCA↓, 1,   TCA↑, 1,   TS↓, 1,   Warburg↓, 9,  

Cell Death(tgid=5) ⓘ

AIF↑, 36,   AIF↝, 1,   APAF1↑, 12,   Apoptosis?, 4,   Apoptosis↓, 8,   Apoptosis↑, 385,   mt-Apoptosis↑, 4,   ASC↑, 1,   ASK1↑, 2,   BAD↓, 3,   BAD↑, 21,   Bak↓, 1,   Bak↑, 15,   BAX↓, 4,   BAX↑, 189,   Bax:Bcl2↓, 1,   Bax:Bcl2↑, 57,   Bcl-2↓, 196,   Bcl-2↑, 2,   Bcl-2∅, 1,   cl‑Bcl-2↑, 1,   Bcl-xL↓, 41,   Bcl-xL↑, 1,   BID↓, 1,   BID↑, 15,   p‑BID↓, 1,   cl‑BID↑, 3,   BIM↓, 1,   BIM↑, 10,   BNIP3?, 1,   BNIP3↑, 3,   BNIP3↝, 2,   BOK↑, 1,   Casp↓, 2,   Casp↑, 76,   cl‑Casp↑, 1,   Casp1↓, 1,   Casp1↑, 2,   Casp10↑, 2,   Casp12↑, 11,   cl‑Casp12↑, 1,   pro‑Casp12↓, 1,   Casp2↑, 1,   Casp3?, 3,   Casp3↓, 6,   Casp3↑, 276,   cl‑Casp3↓, 2,   cl‑Casp3↑, 51,   proCasp3↓, 1,   proCasp3↑, 3,   pro‑Casp3↑, 1,   CASP4↑, 2,   Casp6↑, 2,   Casp7↑, 20,   cl‑Casp7↑, 3,   Casp8↓, 1,   Casp8↑, 65,   Casp8∅, 2,   cl‑Casp8↑, 10,   proCasp8↑, 2,   Casp9↓, 1,   Casp9↑, 178,   cl‑Casp9↓, 1,   cl‑Casp9↑, 23,   proCasp9↓, 2,   proCasp9↑, 3,   cFLIP↓, 7,   Cupro↑, 2,   Cyt‑c↓, 4,   Cyt‑c↑, 243,   Cyt‑c↝, 1,   Diablo↑, 14,   DR5↑, 29,   Endon↑, 5,   FADD↑, 8,   Fap1↓, 2,   Fas?, 1,   Fas↓, 3,   Fas↑, 32,   FasL↓, 1,   FasL↑, 16,   Ferroptosis↑, 17,   GranB/GZMB↝, 1,   GSDMD↑, 1,   GSDME-N↑, 1,   HEY1↓, 1,   IAP1↓, 9,   IAP2/BIRC3↓, 4,   ICAD↓, 1,   ICD↑, 4,   iNOS↓, 15,   iNOS↑, 1,   Mcl-1↓, 20,   Mcl-1↑, 1,   p‑Mcl-1↓, 1,   MDM2↓, 12,   p‑MDM2↓, 1,   MLKL↑, 2,   p‑MLKL↓, 1,   MOMP↓, 1,   MOMP↑, 7,   NAIP↓, 1,   Necroptosis↑, 6,   necrosis↑, 9,   NOXA↑, 3,   p38↓, 8,   p38↑, 27,   p‑p38↓, 2,   p‑p38↑, 5,   Paraptosis↑, 4,   Perforin↝, 1,   PUMA↓, 1,   PUMA↑, 5,   Pyro↑, 5,   RIP3↑, 3,   p‑RIP3↑, 2,   survivin↓, 49,   TNFR 1↑, 3,   TRAIL↑, 8,   TRAIL⇅, 1,   TRAILR↑, 5,   TumCD↑, 46,   TUNEL↑, 1,   XIAP↓, 31,   XIAP↑, 1,   YAP/TEAD↓, 6,  

Kinase & Signal Transduction(tgid=6) ⓘ

ABL1↓, 1,   Akt↓, 145,   Akt↑, 5,   p‑Akt↓, 37,   p‑Akt↑, 1,   AKT1↓, 2,   Akt2↓, 1,   AMPKα↑, 2,   CIP2A↓, 2,   CK2↓, 3,   cMET↓, 1,   p‑cMET↑, 1,   EF-1α↓, 1,   EGFR↓, 31,   EGFR↑, 1,   p‑EGFR↓, 1,   ERK↓, 51,   ERK↑, 9,   p‑ERK↓, 18,   p‑ERK↑, 7,   e-ERK↑, 1,   FOXD3↑, 1,   HER2/EBBR2↓, 11,   HGF/c-Met↓, 1,   Hippo↓, 1,   Hippo↑, 1,   Hippo↝, 1,   HRAS↓, 1,   IGF-1R↓, 2,   IGF-1R↑, 1,   IGFR↓, 1,   IKKα↓, 3,   IKKα↑, 3,   p‑IKKα↓, 1,   IκB↑, 2,   p‑IκB↓, 1,   p‑IκB↑, 1,   JAK↓, 5,   JAK1↓, 2,   JAK1↑, 2,   JAK2↓, 7,   JAK3↓, 1,   JNK↓, 8,   JNK↑, 30,   JNK↝, 1,   p‑JNK↓, 1,   p‑JNK↑, 8,   MAP2K1/MEK1↓, 1,   MAPK↓, 32,   MAPK↑, 19,   p‑MAPK↓, 1,   p‑MAPK↑, 4,   MARK4↓, 1,   MEK↓, 8,   p‑MEK↑, 1,   MKK4↓, 1,   MKP1↓, 1,   MKP2↓, 1,   mTOR↓, 71,   mTOR↑, 1,   p‑mTOR↓, 14,   mTORC2↓, 3,   NRAS↓, 1,   p70S6↓, 3,   p‑p70S6↑, 1,   P70S6K↓, 5,   p‑P70S6K↓, 1,   P90RSK↓, 1,   PDGFR-BB↓, 1,   PI3K↓, 99,   PI3K↑, 3,   p‑PI3K↓, 6,   PI3K/Akt↓, 3,   PI3k/Akt/mTOR↓, 1,   PIK3CA↓, 1,   PKA↓, 2,   PKCδ↓, 12,   p‑PKCδ↓, 1,   PP2A↑, 1,   PRAS40↑, 1,   PTEN↓, 2,   PTEN↑, 18,   Raf↓, 6,   c-Raf↓, 1,   RAS↓, 11,   RIP1↓, 1,   RIP1↑, 1,   p‑S6K↓, 1,   SHP1↑, 1,   Sp1/3/4↓, 15,   Src↑, 1,   STAT↓, 3,   STAT3↓, 61,   STAT3↑, 3,   STAT3↝, 1,   p‑STAT3↓, 9,   p‑STAT3↑, 3,   STAT6↓, 1,   THEM4/CTMP↑, 1,   TSC2↑, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF3↓, 1,   ATF3↑, 2,   ATF4↓, 1,   ATF4↑, 12,   ATFs↑, 1,   ChrMod↑, 1,   ChrMod↝, 1,   cJun↓, 8,   cJun↑, 6,   p‑cJun↑, 2,   cMyc↓, 20,   cMyc↑, 1,   DNMT1↓, 2,   DNMT3B↓, 1,   DNMTs↓, 6,   EZH2↓, 3,   FOXM1↓, 3,   FOXO↑, 1,   FOXO1↓, 2,   FOXO1↑, 1,   FOXO3↓, 3,   FOXO3↑, 7,   FOXO3↝, 1,   FOXO4↓, 1,   FOXO4↑, 1,   GATA3↑, 1,   H3↓, 1,   H3↑, 2,   p‑H3↓, 1,   p‑H3↑, 1,   ac‑H3↑, 2,   H4↑, 1,   ac‑H4↑, 2,   HATs↓, 5,   HATs↑, 3,   HDAC↓, 26,   HDAC1↓, 4,   HDAC10↑, 1,   HDAC2↓, 5,   HDAC3↓, 4,   HDAC6↓, 2,   HDAC8↓, 2,   HMTs↓, 1,   miR-106b↓, 1,   miR-124-3p↓, 1,   miR-133a-3p↑, 1,   miR-139-5p↑, 1,   miR-148a↑, 1,   miR-155↓, 1,   miR-203↑, 1,   miR-21↓, 4,   miR-22↑, 2,   miR-34a↑, 4,   MTA2↓, 1,   Myc↓, 5,   n-MYC↓, 1,   OCT4↓, 12,   other↓, 7,   other↑, 9,   other↝, 12,   sonoS↑, 1,   SOX2↓, 11,   SOX4↓, 3,   SOX9↓, 1,   SUV39H↓, 1,   TCF-4↓, 2,   TFE3↑, 2,   tumCV?, 2,   tumCV↓, 106,   tumCV↑, 1,   tumCV∅, 1,   UTF1↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 3,   cl‑ATF6↑, 2,   CHOP/DDIT3↓, 1,   CHOP/DDIT3↑, 38,   cl‑CHOP/DDIT3↑, 1,   CRT↑, 1,   eIF2α↓, 1,   eIF2α↑, 9,   p‑eIF2α↓, 1,   p‑eIF2α↑, 4,   ER Stress↓, 3,   ER Stress↑, 71,   ER Stress↝, 1,   GRP78/BiP?, 1,   GRP78/BiP↓, 1,   GRP78/BiP↑, 24,   GRP78/BiP↝, 1,   GRP94↑, 4,   HSF1↓, 1,   HSP27↓, 8,   HSP70/HSPA5↓, 4,   HSP70/HSPA5↑, 1,   HSP72↓, 1,   HSP90↓, 12,   HSP90↑, 2,   HSPs↓, 1,   HTRA↓, 1,   IRE1↑, 6,   PDI↑, 1,   PERK↑, 13,   Proteasome↓, 1,   UPR↓, 1,   UPR↑, 17,   XBP-1↓, 2,   XBP-1↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG13↑, 1,   ATG16L1↑, 1,   ATG3↑, 3,   ATG5↑, 11,   ATG7↑, 3,   autoF↓, 1,   Beclin-1/ATG6↓, 4,   Beclin-1/ATG6↑, 16,   CTSB↓, 1,   CTSD↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 3,   LC3A↑, 2,   LC3B↑, 6,   LC3B-II↑, 3,   LC3II↑, 21,   LC3s↑, 1,   lysoMP↑, 2,   lysosome↝, 1,   MitoP↓, 1,   MitoP↑, 5,   p62↓, 11,   p62↑, 5,   PARK2↑, 5,   RUBCN↓, 1,   SESN2↑, 1,   TumAuto↓, 1,   TumAuto↑, 71,   TumAuto⇅, 2,   ULK1/ATG1↑, 1,   p‑ULK1/ATG1↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

APE1/APEX1↓, 1,   ATM↑, 5,   BRCA1↓, 3,   p‑BRCA1↑, 1,   BRCA2↓, 1,   DFF45↓, 1,   DFF45↑, 2,   DNA-PK↑, 2,   DNAdam↓, 5,   DNAdam↑, 121,   mt-DNAdam↑, 1,   DNArepair↓, 2,   hTERT/TERT↓, 9,   MGMT↓, 1,   p16↑, 1,   P53↓, 3,   P53↑, 113,   P53↝, 2,   P53∅, 1,   p‑P53↑, 10,   ac‑P53↑, 1,   p53 Wildtype∅, 1,   PARP↓, 10,   PARP↑, 22,   p‑PARP↑, 2,   cl‑PARP↓, 3,   cl‑PARP↑, 109,   PARP1↑, 2,   cl‑PARP1↑, 3,   PCNA↓, 30,   POLD1↓, 1,   SIRT6↓, 2,   SIRT6↑, 1,   Telomerase↓, 13,   TOP1?, 1,   TOP1↓, 13,   TOP1∅, 1,   TOP2↓, 5,   TP53↓, 3,   TP53↑, 4,   TRF2↓, 1,   γH2AX↑, 12,   p‑γH2AX↑, 2,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 18,   CDK1↑, 2,   CDK1↝, 1,   p‑CDK1↓, 1,   CDK2↓, 38,   CDK2↑, 2,   CDK4↓, 43,   p‑CDK4↓, 1,   CDK6↓, 15,   CDK6↑, 2,   CDK7↓, 1,   CDK8↓, 1,   CDKN1C/p57↓, 1,   CDKN1C/p57↑, 1,   CHK1↓, 2,   CHK1↑, 1,   CHK1↝, 1,   Chk2↓, 2,   Chk2↑, 3,   ChrCon↑, 1,   Cyc↓, 2,   cycA1/CCNA1↓, 14,   cycA1/CCNA1↑, 1,   CycB/CCNB1↓, 23,   CycB/CCNB1↑, 5,   CycB/CCNB1↝, 1,   cycD1/CCND1↓, 79,   cycD1/CCND1↑, 1,   p‑cycD1/CCND1↓, 1,   CycD3↓, 3,   cycE/CCNE↓, 22,   cycE1↓, 2,   E2Fs↓, 2,   E2Fs↑, 1,   GADD45A↓, 1,   Ki-67↓, 22,   MAD↓, 1,   mitA↓, 1,   mitA↑, 2,   p19↑, 1,   P21?, 2,   P21↓, 5,   P21↑, 71,   p27/CDKN1B↓, 2,   p27/CDKN1B↑, 27,   pRB↓, 1,   p‑pRB↓, 1,   RB1↑, 2,   p‑RB1↓, 5,   Securin↓, 1,   TumCCA?, 2,   TumCCA↓, 8,   TumCCA↑, 287,   WEE1↑, 2,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

4E-BP1↓, 2,   p‑4E-BP1↓, 1,   ALDH↓, 7,   ALDH1A1↓, 2,   BMI1↓, 1,   CD133↓, 9,   CD24↓, 3,   CEBPA↑, 1,   cFos↓, 7,   CSCs?, 1,   CSCs↓, 51,   Diff↓, 2,   Diff↑, 2,   FGF↓, 2,   Gli↓, 1,   Gli1↓, 6,   HH↓, 3,   HMGCR↓, 1,   IGF-1↓, 5,   p‑IGF-1↓, 1,   IGF-2↓, 1,   IGFBP3↑, 2,   Ki-67↓, 22,   Let-7↑, 3,   mTORC1↓, 7,   p‑mTORC1↓, 1,   Nanog↓, 13,   Nestin↓, 3,   NOTCH↓, 13,   NOTCH1↓, 11,   NOTCH1↑, 2,   NOTCH2↑, 1,   NOTCH3↓, 3,   PTCH1↓, 2,   Shh↓, 5,   Smo↓, 4,   TumCG?, 3,   TumCG↓, 139,   TumCG↑, 3,   TumCP↓, 183,   TumCP↑, 4,   tyrosinase↓, 1,   Wnt?, 1,   Wnt↓, 29,   Wnt↑, 1,   Wnt/(β-catenin)↓, 4,  

Migration(tgid=13) ⓘ

Alix/AIP‑1↓, 1,   AntiAg↓, 1,   AP-1↓, 6,   ASAP2↓, 1,   ATPase↓, 1,   ATPase↑, 1,   AXL↓, 1,   BACH1↓, 1,   CA↓, 1,   Ca+2?, 1,   Ca+2↓, 4,   Ca+2↑, 88,   Ca+2↝, 6,   i-Ca+2?, 1,   i-Ca+2↑, 5,   mt-Ca+2↑, 1,   CAFs/TAFs↓, 1,   Cal1↑, 2,   cal2↑, 3,   CCN2/CTGF↓, 1,   Cdc42↓, 1,   Chl↑, 1,   COL1↓, 2,   COL1A1↓, 1,   COL3A1↓, 2,   E-cadherin↓, 4,   E-cadherin↑, 40,   EMT↓, 65,   EMT↑, 2,   EpCAM↓, 2,   F-actin↓, 1,   FAK↓, 12,   p‑FAK↓, 3,   Fibronectin↓, 4,   GIT1↓, 1,   GLI2↓, 2,   ITGB1↓, 1,   ITGB6↓, 1,   KRAS↓, 3,   LAMs↓, 2,   LEF1↓, 2,   LRP1↓, 1,   MALAT1↓, 4,   MET↓, 2,   MMP-10↓, 3,   MMP1↓, 3,   MMP13↓, 3,   MMP15↓, 1,   MMP2↓, 80,   MMP2↑, 1,   proMMP2↓, 1,   MMP3↓, 6,   MMP7↓, 8,   MMP9↓, 84,   MMP9↑, 1,   MMPs↓, 24,   MTA1↓, 1,   MUC4↓, 1,   N-cadherin↓, 23,   PAK1↓, 3,   PAK1↑, 1,   pax↓, 1,   p‑pax↓, 1,   PDGF↓, 3,   Rac1↓, 1,   RECK↑, 1,   Rho↓, 4,   ROCK1↓, 2,   ROCK1↑, 1,   Slug?, 1,   Slug↓, 10,   Smad1↓, 1,   Smad1↑, 1,   SMAD2↓, 1,   SMAD3↓, 3,   SMAD4↓, 2,   p‑SMAD4↓, 1,   Snail?, 1,   Snail↓, 27,   T-cadherin↓, 1,   talin?, 1,   TET1↓, 1,   TET1↑, 2,   TGF-β↓, 14,   TGF-β↑, 2,   TGF-β1↓, 1,   TIMP1↓, 3,   TIMP1↑, 8,   TIMP2↓, 5,   TIMP2↑, 8,   TRIB3↑, 1,   TSC1↑, 1,   TSP-1↑, 2,   TumCI?, 1,   TumCI↓, 70,   TumCI↑, 1,   TumCMig↓, 74,   TumCMig↑, 1,   TumMeta↓, 61,   TumMeta↑, 2,   TumPF↓, 1,   Twist↓, 16,   uPA↓, 18,   uPA↝, 1,   uPAR↓, 2,   Vim?, 1,   Vim↓, 34,   Zeb1↓, 12,   Zeb1↑, 1,   ZEB2↓, 1,   α-SMA↓, 2,   α-SMA↑, 1,   α-tubulin↓, 1,   β-catenin/ZEB1↓, 34,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 81,   angioG↑, 3,   CCN1/CYR61↓, 1,   CD31/PECAM-1↓, 6,   EGR1↑, 1,   Endoglin↑, 2,   eNOS↓, 1,   eNOS↑, 1,   HIF-1↓, 5,   Hif1a↓, 57,   Hif1a↑, 2,   LOX1↓, 1,   NO↓, 2,   NO↑, 8,   PHDs↓, 1,   VCAM-1↓, 1,   VEGF↓, 81,   VEGFR1↓, 2,   VEGFR2/KDR/Flk1↓, 11,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 6,   BBB∅, 2,   CellMemb↓, 1,   CellMemb↑, 6,   CLDN1↓, 4,   CLDN1↑, 1,   CLDN2↓, 2,   EPR↑, 2,   EPR↝, 1,   GLUT1↓, 13,   GLUT2↓, 1,   GLUT3↓, 1,   GLUT4↓, 4,   IBI↑, 1,   memfluid↓, 1,   MMP?, 4,   MMP↓, 695,   MMP↑, 15,   MMP↝, 4,   MMP∅, 4,   MPT↑, 19,   NHE1↓, 2,   OCLN↑, 1,   SMCT1∅, 1,   sonoP↑, 1,   TJ↑, 1,   TRPM7↓, 2,   TRPV1↑, 8,   TRPV1↝, 1,   VGCC↓, 1,   VGSC↓, 1,   ZO-1↑, 3,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CCR7↓, 1,   CD155↓, 1,   CD25+↑, 1,   CD4+↓, 1,   CD4+↑, 4,   CD44↓, 17,   CD47↓, 2,   CD59↑, 1,   CD8+↑, 6,   cDC2↓, 1,   cGAS–STING↑, 1,   COX1↓, 2,   COX2/PTGS2↓, 61,   COX2/PTGS2↑, 2,   CXCL12↓, 1,   CXCR4↓, 7,   DCells↑, 1,   DR4↑, 9,   DR4∅, 1,   FOXP3↑, 2,   HMGB1↓, 3,   HMGB1↑, 1,   ICAM-1↓, 2,   IFN-γ↓, 4,   IFN-γ↑, 1,   IL1↓, 5,   IL1↑, 1,   IL10↓, 5,   IL12↑, 1,   IL17↓, 1,   IL1β↓, 14,   IL1β↑, 1,   IL2↓, 1,   IL2↑, 2,   IL4↓, 1,   IL4↑, 1,   IL6↓, 37,   IL6↑, 1,   IL8↓, 7,   IL8↑, 1,   Imm↑, 10,   Imm↝, 2,   Inflam↓, 33,   IRAK1↓, 1,   IRAK4↓, 1,   LRIG1↑, 1,   M2 MC↓, 1,   Macrophages↓, 1,   MCP1/CCL2↓, 5,   MCT1↓, 2,   MDSCs↓, 1,   MIP2↓, 1,   Neut↓, 1,   NF-kB↓, 131,   NF-kB↑, 12,   p‑NF-kB↓, 3,   NK cell↑, 4,   NLRP3↓, 3,   p50↓, 1,   p65↓, 10,   p65↑, 1,   p‑p65↓, 1,   p‑p65↑, 1,   PD-1↓, 3,   PD-L1↓, 9,   PGE2↓, 17,   PSA↓, 9,   RAGE↓, 1,   RANTES?, 1,   SOCS-3↓, 1,   T-Cell↑, 3,   TCF↓, 3,   TCF↑, 1,   TCF↝, 1,   Th1 response↑, 1,   TIGIT↓, 1,   TLR1↑, 1,   TLR4↓, 8,   TNF-α↓, 28,   TNF-α↑, 2,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 2,  

Cellular Microenvironment(tgid=17) ⓘ

GGT/CD224↑, 1,   pH↓, 2,   pH↝, 1,   e-pH↑, 1,   i-pH↑, 1,   TAMS↝, 1,   Temp∅, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 1,   BChE↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 1,   AhR↓, 2,   AhR↑, 1,   AR↓, 10,   AR↑, 2,   ER-α36↓, 3,   ER-α36↝, 1,   ER(estro)↓, 1,   PPARα↓, 1,   PPARγ↓, 1,   PPARγ↑, 4,   RANKL↓, 1,   SXR↓, 1,   SXR↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABC↓, 1,   ABCG2↓, 2,   BioAv↓, 35,   BioAv↑, 40,   BioAv↝, 8,   BioEnh↑, 2,   ChemoSen↓, 2,   ChemoSen↑, 157,   ChemoSen⇅, 1,   ChemoSen↝, 1,   CompStab↑, 2,   CompStab↝, 1,   CYP1A1↓, 3,   CYP1A1↑, 2,   CYP1A2↑, 1,   CYP2A3/CYP2A6↓, 1,   CYP2E1↑, 1,   CYP3A4↓, 3,   DDS↑, 1,   Dose?, 7,   Dose↓, 3,   Dose↑, 9,   Dose⇅, 2,   Dose↝, 61,   Dose∅, 18,   DrugR↓, 1,   eff↓, 120,   eff↑, 127,   eff↝, 18,   GSTA1↓, 1,   Half-Life↓, 10,   Half-Life↝, 12,   MDR1↓, 7,   MRP1/ABCC1↓, 1,   MRP1/ABCC1↝, 1,   P-gp/ABCB1↓, 20,   P-gp/ABCB1↑, 1,   P-gp/ABCB1∅, 1,   P450↓, 4,   P450↝, 1,   RadioS↑, 49,   RadioS↝, 1,   selectivity?, 1,   selectivity↓, 2,   selectivity↑, 167,   selectivity↝, 1,   selectivity∅, 1,   Synergy↑, 105,  

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 2,   ALAT↓, 4,   ALAT↑, 1,   ALAT∅, 1,   ALP↓, 2,   AR↓, 10,   AR↑, 2,   AST↓, 2,   AST↑, 1,   AST∅, 1,   BMD↑, 1,   BRCA1↓, 3,   p‑BRCA1↑, 1,   CEA↓, 1,   CRP↓, 2,   E6↓, 2,   E7↓, 2,   EGFR↓, 31,   EGFR↑, 1,   p‑EGFR↓, 1,   EZH2↓, 3,   FOXM1↓, 3,   HER2/EBBR2↓, 11,   hTERT/TERT↓, 9,   IL6↓, 37,   IL6↑, 1,   KRAS↓, 3,   LDH↓, 11,   LDH↑, 6,   LDH↝, 1,   e-LDH↑, 1,   i-LDH↓, 1,   Myc↓, 5,   PD-L1↓, 9,   PSA↓, 9,   PSADT↑, 1,   RAGE↓, 1,   TP53↓, 3,   TP53↑, 4,   TRIB3↑, 1,   Tumccf↓, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 64,   antiNeop↑, 5,   AntiTum↑, 27,   Appetite↑, 1,   BowelM↑, 1,   breath↑, 1,   cardioP↑, 13,   chemoP↑, 29,   chemoPv↑, 27,   chemoPv⇅, 1,   ChemoSideEff↓, 3,   cognitive↑, 1,   fatigue∅, 1,   hepatoP↑, 11,   hepatoP∅, 1,   K17↓, 1,   neuroP↑, 5,   NP/CIPN↓, 2,   Obesity↓, 2,   OS↑, 14,   OS⇅, 1,   Pain↓, 4,   PFS↓, 1,   PFS↑, 1,   Pin1↓, 1,   QoL↑, 6,   QoL∅, 1,   radioP↑, 5,   Remission↑, 2,   RenoP↑, 8,   Risk↓, 18,   Sleep↑, 1,   Strength↑, 2,   toxicity↓, 20,   toxicity↑, 3,   toxicity↝, 6,   toxicity∅, 6,   TumNum↓, 1,   TumVol↓, 23,   TumVol↑, 1,   TumW↓, 9,   Weight↑, 3,   Weight∅, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiP↑, 1,   Bacteria↓, 3,   GutMicro↑, 4,   GutMicro↝, 2,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 4,   Ingr↝, 6,  
Total Targets: 1128

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx?, 1,   antiOx↓, 7,   antiOx↑, 105,   i-antiOx↑, 1,   ARE↑, 1,   Catalase↓, 1,   Catalase↑, 47,   GCLC↑, 1,   GCLM↑, 1,   GPx↑, 25,   GPx1↑, 3,   GPx4↑, 3,   GSH↓, 1,   GSH↑, 41,   GSR↑, 7,   GSTs↓, 1,   GSTs↑, 14,   H2O2↓, 5,   HDL↑, 2,   HO-1↓, 2,   HO-1↑, 25,   i-Iron↓, 1,   Keap1↓, 3,   Keap1↑, 1,   Keap1↝, 1,   lipid-P↓, 32,   lipid-P↑, 1,   mt-lipid-P↓, 1,   MDA↓, 24,   MDA↑, 2,   MPO↓, 6,   NADH↓, 1,   NQO1↑, 5,   Nrf1↑, 2,   NRF2↑, 51,   p‑NRF2↑, 1,   Prx↑, 2,   RNS↓, 2,   ROS?, 2,   ROS↓, 137,   ROS↑, 12,   ROS⇅, 1,   ROS∅, 8,   mt-ROS?, 1,   mt-ROS↓, 3,   SOD↓, 2,   SOD↑, 53,   SOD1↑, 2,   SOD2↑, 3,   TAC↑, 5,   TBARS↓, 2,   TOS↓, 1,   Trx↑, 2,   Trx1↑, 2,   UCPs↑, 1,   uricA↓, 1,   VitC↑, 2,   VitE↑, 1,   xCT/SLC7A11↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 4,   IronCh↝, 1,   Mets↝, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compII↑, 1,   compIII↑, 1,   compIV↑, 2,   DRP1/DNM1L↓, 2,   DRP1/DNM1L↑, 1,   ETC↓, 1,   ETC↑, 1,   ETC↝, 1,   FIS1↓, 1,   Insulin↓, 1,   Insulin↑, 1,   MFN1↓, 1,   MFN2↓, 1,   MFN2↑, 2,   mitResp↓, 1,   mitResp↑, 1,   mtDam↓, 5,   OCR↓, 1,   OCR↑, 3,   OPA1↓, 1,   OXPHOS↓, 2,   OXPHOS↑, 2,   PGC-1α↑, 9,   PGC-1α↝, 1,   PINK1↑, 2,   SIRT3↑, 4,   TFAM↑, 3,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 2,   ACC↑, 1,   ALAT↓, 12,   ALDOA↑, 1,   AMPK↑, 14,   p‑AMPK↑, 2,   ATP↓, 2,   ATP↑, 15,   ATP∅, 1,   BMAL1↑, 1,   cAMP↑, 1,   CRM↑, 1,   cytoP450↓, 1,   DGAT1↓, 1,   ECAR↓, 1,   FASN↓, 1,   glucose↓, 4,   glucose↝, 2,   GlucoseCon↑, 2,   GlutMet↑, 1,   glyC↓, 1,   Glycolysis↓, 1,   Glycolysis↑, 2,   GPI↑, 1,   GSK‐3β↓, 5,   GSK‐3β↑, 2,   p‑GSK‐3β↑, 2,   HK2↑, 2,   KeyT↝, 1,   LDHA↑, 2,   LDL↓, 4,   lipidLev↓, 1,   NADH:NAD↑, 1,   NADPH↓, 2,   PFKL↑, 2,   PFKM↑, 1,   PFKP↑, 1,   PKM1↑, 1,   PKM2↑, 1,   SCFAs↑, 1,   SIRT1↑, 11,   SIRT2↑, 1,   SREBP1/SREBF1↑, 1,  

Cell Death(tgid=5) ⓘ

AIF↓, 1,   AIF↑, 1,   APAF1↓, 1,   Apoptosis↓, 22,   Apoptosis∅, 1,   mt-Apoptosis↓, 1,   ASC↓, 1,   BAX↓, 12,   BAX↑, 5,   Bax:Bcl2↓, 2,   Bax:Bcl2↑, 2,   Bcl-2↓, 5,   Bcl-2↑, 7,   Bcl-2∅, 1,   Bcl-xL↓, 1,   Casp↓, 1,   Casp1↓, 2,   cl‑Casp1↓, 1,   Casp12↓, 1,   Casp3?, 1,   Casp3↓, 18,   Casp3↑, 6,   Casp3∅, 1,   cl‑Casp3↓, 1,   cl‑Casp3↑, 1,   Casp8↑, 1,   cl‑Casp8↑, 1,   Casp9↓, 4,   Casp9↑, 2,   cl‑Casp9↓, 1,   cl‑Casp9↑, 1,   Cyt‑c↓, 9,   Cyt‑c↑, 3,   Cyt‑c∅, 3,   Fas↑, 2,   Ferroptosis↓, 3,   GranB/GZMB↓, 1,   GSDMD↓, 1,   iNOS↓, 16,   iNOS↑, 1,   necrosis↓, 2,   p38↓, 3,   p‑p38↓, 1,   Pyro↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 4,   Akt↑, 6,   p‑Akt↓, 1,   p‑Akt↑, 2,   CREB↑, 1,   p‑CREB↑, 2,   ERK↑, 4,   p‑ERK↓, 2,   p‑ERK↑, 1,   IκB?, 1,   JNK↓, 1,   JNK↑, 2,   p‑JNK↓, 4,   p‑JNK↑, 1,   MAPK↓, 7,   MAPK↑, 1,   mTOR↓, 3,   mTOR↑, 1,   PI3K↓, 4,   PI3K↑, 4,   p‑PI3K↑, 1,   PTEN↑, 1,   Src↓, 1,   STAT3↓, 1,   STAT3↑, 1,   STK11/LKB1↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 4,   ATF2↑, 1,   ATF4↓, 1,   cMyc↓, 1,   p‑cMyc↑, 1,   FOXO↑, 1,   FOXO3↑, 1,   other↓, 2,   other↑, 7,   other↝, 7,   RUNX2↑, 1,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↓, 2,   CHOP/DDIT3↓, 3,   CHOP/DDIT3↑, 1,   p‑eIF2α↓, 1,   cl‑eIF2α↑, 1,   ER Stress↓, 7,   GRP78/BiP↓, 6,   GRP78/BiP↑, 1,   HSP70/HSPA5↑, 2,   HSP70/HSPA5↝, 1,   HSPs↑, 2,   IRE1↓, 2,   PDI↓, 1,   PERK↓, 1,   p‑PERK↑, 1,   UPR↓, 1,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 2,   Beclin-1/ATG6↑, 2,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3A↑, 1,   LC3B↑, 1,   LC3II↑, 2,   MitoP↑, 2,   p62↓, 3,   p62↑, 4,   PARK2↑, 3,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 4,   p16↓, 1,   P53↓, 2,   P53↑, 3,   cl‑PARP↓, 1,   cl‑PARP↑, 2,   PARP1↓, 1,   PCNA↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1,   CDK2↓, 2,   CDK4↓, 1,   cycA1/CCNA1↓, 1,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 2,   cycE/CCNE↓, 1,   cycE/CCNE↑, 1,   P21↓, 3,   P21↑, 3,   RB1↓, 1,   TumCCA↑, 3,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMP2↑, 1,   Diff↑, 1,   HH↓, 1,   IGF-1↓, 1,   IGF-1↑, 2,   IGFBP3↑, 1,   neuroG↑, 1,   TumCG↓, 2,   TumCP↓, 2,  

Migration(tgid=13) ⓘ

AntiAg↑, 8,   AP-1↓, 2,   Ca+2?, 1,   Ca+2↓, 13,   Ca+2↑, 3,   Ca+2↝, 2,   i-Ca+2↓, 1,   cal2↓, 3,   Cartilage↑, 1,   COL1↑, 1,   MMP13↓, 1,   MMP2↓, 1,   MMP2↑, 1,   MMP3↓, 1,   MMP9↓, 6,   MMP9↑, 1,   MMPs↓, 1,   PAI-1/SERPINE1↓, 1,   TGF-β↓, 2,   TGF-β↑, 1,   TIMP1↓, 1,   TregCell↑, 1,   TumCI↓, 1,   TXNIP↓, 1,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   angioG↑, 4,   E-sel↓, 1,   Hif1a↑, 2,   NO↓, 8,   NO↑, 1,   VCAM-1↓, 1,   VEGF↓, 1,   VEGF↑, 2,  

Barriers & Transport(tgid=15) ⓘ

BBB?, 1,   BBB↓, 3,   BBB↑, 14,   BBB↝, 1,   BBB∅, 2,   CellMemb↑, 1,   CLDN5↓, 1,   CLDN5↑, 1,   GastroP↑, 4,   GLUT1↑, 2,   GLUT3↑, 1,   GLUT4↑, 2,   H+/K+-ATPase↓, 1,   IBI↑, 1,   MMP↓, 16,   MMP↑, 81,   MMP⇅, 1,   MMP↝, 2,   MMP∅, 4,   MPT↑, 1,   MUC5AC↓, 1,   OCLN↓, 1,   TJ↑, 1,   TRPM7↓, 1,   TRPV1↑, 2,   VGCC↑, 1,   VGCC⇅, 1,   ZO-1↓, 1,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

AIF1/Iba-1↓, 1,   CCL11↓, 1,   CD4+↑, 2,   CD8+↑, 1,   COX1↓, 2,   COX2/PTGS2↓, 29,   COX2/PTGS2↑, 1,   CXCL12↑, 1,   CXCR4↓, 1,   HMGB1↓, 1,   IFN-γ↓, 2,   IFN-γ↑, 1,   IL1↓, 1,   IL10↓, 3,   IL10↑, 4,   IL12↓, 2,   IL17↓, 3,   IL18↓, 4,   IL1β↓, 21,   IL2↓, 2,   IL22↓, 1,   IL4↓, 3,   IL6↓, 19,   IL6↑, 1,   IL8↓, 1,   Imm↑, 6,   Imm⇅, 1,   Inflam↓, 112,   Inflam↑, 1,   IP-10/CXCL-10↓, 1,   IRF3↓, 1,   LPS↓, 1,   pol-M2 MC↑, 2,   MCP1/CCL2↓, 3,   MyD88↓, 1,   NeuroI↓, 5,   NF-kB↓, 40,   NF-kB↑, 1,   NK cell↑, 1,   NLRP3↓, 7,   p65↓, 1,   PAR-2↓, 1,   PGE2↓, 11,   PGE2↑, 1,   TLR1↓, 2,   TLR2↓, 1,   TLR4↓, 3,   TNF-α↓, 29,   TRIF↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

GFAP↓, 3,   pH↝, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   5HT↑, 1,   Ach↑, 4,   AChE↓, 20,   AChE↑, 1,   ADAM10↑, 1,   BChE↓, 4,   BDNF↑, 11,   ChAT↑, 1,   GABA↑, 1,   MAOA↓, 3,   NGF↑, 2,   PSD95↑, 3,   RELN↑, 1,   SNAP25↑, 3,   β-Endo↑, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 2,   APP↓, 3,   Aβ↓, 26,   Aβ42↓, 2,   BACE/β-secretase↓, 5,   PSEN1/PS1↓, 1,   tau↓, 4,   p‑tau↓, 6,   XO↓, 1,   XO↝, 1,   β-Amyloid↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 1,   ACE2↓, 1,   Estro↓, 1,   PPARα↑, 2,   PPARγ↑, 5,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 31,   BioAv↑, 36,   BioAv↝, 15,   CompStab↑, 2,   CYP1A1↑, 1,   CYP1A2↑, 1,   CYP2E1↓, 2,   Dose⇅, 1,   Dose↝, 21,   Dose∅, 1,   eff↓, 3,   eff↑, 16,   eff↝, 1,   GSTA1↑, 1,   Half-Life↓, 6,   Half-Life↑, 2,   Half-Life↝, 9,   P-gp/ABCB1↓, 1,   P450↓, 1,   P450↑, 1,   selectivity↑, 2,   Synergy↑, 7,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 12,   ALP↓, 3,   AST↓, 14,   BG↓, 2,   BloodF↑, 4,   BMD↑, 3,   BP↓, 4,   BP↝, 1,   BUN↓, 2,   creat↓, 6,   CRP↓, 4,   IL6↓, 19,   IL6↑, 1,   IRes↝, 1,   KeyT↝, 1,   LDH↓, 6,   LDH↑, 1,   NOS2↓, 2,   TC↓, 1,   TG/TAG↓, 1,   Urea↓, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 8,   antiAll?, 1,   antiAll↑, 8,   AntiArt↑, 5,   AntiCan↑, 19,   antiD↓, 1,   AntiDiabetic↑, 19,   AntiMyl↑, 1,   antiNeop↑, 1,   antiPs↑, 2,   AntiTum↓, 1,   AntiTum↑, 5,   ANXi↓, 1,   cardioP↓, 1,   cardioP↑, 35,   chemoP↑, 8,   chemoPv↑, 1,   cognitive↑, 24,   cough?, 1,   hepatoP↑, 31,   Learn↑, 4,   memory↑, 24,   Mood?, 1,   motorD↓, 1,   motorD↑, 9,   Mucositis↓, 1,   neuroP?, 1,   neuroP↓, 2,   neuroP↑, 88,   NP/CIPN↓, 1,   Obesity↓, 10,   OS↑, 2,   Pain↓, 7,   radioP↑, 5,   RenoP↑, 11,   Risk↓, 2,   Sleep↑, 2,   SoreThr?, 1,   Strength↑, 2,   Stress↓, 1,   Stroke↓, 8,   toxicity↓, 40,   toxicity↑, 4,   toxicity↝, 9,   toxicity∅, 7,   Wound Healing↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 9,   AntiFungal↑, 2,   AntiP↑, 6,   AntiViral↑, 8,   Bacteria↓, 20,   Diar↓, 1,   GutMicro↑, 13,   Sepsis↓, 3,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,   Ingr↑, 1,   Ingr↝, 2,  
Total Targets: 517

Scientific Paper Hit Count for: MMP, ΔΨm, mitochondrial membrane potential
32 Silver-NanoParticles
26 Quercetin
21 Betulinic acid
21 Capsaicin
18 Baicalein
18 Sulforaphane (mainly Broccoli)
17 Propolis -bee glue
17 Fisetin
16 Curcumin
16 Berberine
16 Magnetic Fields
15 Apigenin (mainly Parsley)
15 Emodin
15 Shikonin
15 Thymoquinone
12 Luteolin
11 Chrysin
11 Resveratrol
10 Ashwagandha(Withaferin A)
10 Phenethyl isothiocyanate
10 Electrical Pulses
10 Gambogic Acid
10 Graviola
10 Selenite (Sodium)
10 Silymarin (Milk Thistle) silibinin
9 Ivermectin
9 Magnolol
9 Vitamin K2
8 Allicin (mainly Garlic)
8 Cisplatin
8 Dichloroacetate
8 Honokiol
8 Kaempferol
8 Licochalcone A
8 Morin
7 Radiotherapy/Radiation
7 Benzyl isothiocyanate
7 Dandelion Root
7 EGCG (Epigallocatechin Gallate)
7 Juglone
7 Linalool
7 Phenylbutyrate
7 salinomycin
6 chitosan
6 doxorubicin
6 Beta-Caryophyllene
6 Carvacrol
6 Lycopene
6 Magnetic Field Rotating
6 Melatonin
6 Parthenolide
5 Allyl isothiocyanate
5 Alpha-Lipoic-Acid
5 Artemisinin
5 Rosmarinic acid
5 Diindolylmethane
5 Indole-3-carbinol
5 Eugenol
5 Ferulic acid
5 isoorientin
5 Vitexin
5 Selenium NanoParticles
5 Ursolic acid
4 Auranofin
4 Vitamin C (Ascorbic Acid)
4 Metformin
4 Boswellia (frankincense)
4 α-Bisabolol / Chamomile oil
4 chaetocin
4 Selenium
4 Crocetin
4 Copper and Cu NanoParticles
4 Date Fruit Extract
4 Ginkgo biloba-EGb 761
4 Evodiamine
4 Formononetin
4 Gallic acid
4 Garcinol
4 HydroxyTyrosol
4 Hyperoside
4 Isobavachalcone
4 Isorhamnetin
4 Licorice
4 Propyl gallate
4 Taurine
3 SonoDynamic Therapy UltraSound
3 Isovitexin
3 Isothiocyanates
3 Boron
3 Thymol-Thymus vulgaris
3 Carvone
3 Cynaropicrin
3 Diclofenac
3 Ellagic acid
3 Fucoidan
3 Paclitaxel/Taxol
3 Geraniol
3 Gossypol/AT-101
3 Hibiscus sabdariffa
3 isoquercitrin
3 Photodynamic Therapy
3 Matrine
3 Methyl Jasmonate
3 Mangiferin
3 Moringa oleifera
3 Piperlongumine
3 Spermidine
3 Urolithin
2 Astragalus
2 Gemcitabine (Gemzar)
2 5-fluorouracil
2 Anethole/trans-Anethole
2 Baicalin
2 Biochanin A
2 Bufalin/Huachansu
2 Bullatacin
2 Celecoxib
2 Celastrol
2 Centella asiatica / Gotu kola → asiaticoside
2 Chlorogenic acid
2 Cinnamon
2 Hydroxycinnamic-acid
2 Citric Acid
2 Coenzyme Q10
2 Chlorella (Chlorella vulgaris)
2 Fenbendazole
2 Flaxseed Oil
2 Ginkgo biloba
2 Ginseng
2 γ-linolenic acid (Borage Oil)
2 Gold NanoParticles
2 Hydrogen Gas
2 Hyperthermia
2 Methylene blue
2 Methylsulfonylmethane
2 Mushroom Chaga, Inonotus obliquus
2 Mushroom Lion’s Mane, Hericium erinaceus
2 Nimbolide
2 Patchouli Oil (Pogostemon cablin)
2 Phycocyanin
2 Piperine
2 Plumbagin
2 Psoralidin
2 VitK3,menadione
1 2-DeoxyGlucose
1 Glucose
1 Camptothecin
1 alpha Linolenic acid
1 DTS(dibenzyl trisulphide) from Anamu
1 Andrographis
1 Angelica archangelica / Garden Angelica
1 Astaxanthin
1 Atorvastatin
1 Aloe anthraquinones
1 Berbamine
1 D-limonene
1 Cannabidiol
1 Brucea javanica
1 Bromelain
1 Chemotherapy
1 Beetroot
1 Bruteridin(bergamot juice)
1 Black turtle bean
1 buckwheat sprouts
1 Butyrate
1 Caffeic acid
1 Carnosic acid
1 Caffeic Acid Phenethyl Ester (CAPE)
1 Chocolate
1 Cichoric acid / Chicoric acid
1 Vitamin E
1 Cynara scolymus/Globe Artichoke/Artichoke Extract
1 Cucurbitacin
1 Dihydrocaffeic Acid
1 Spirulina(Arthrospira/Limnospira)
1 Cyclopamine
1 Dichloroacetophenone(2,2-)
1 Deguelin
1 Mistletoe/Viscum album Extracts
1 Disulfiram
1 Flaxseed/Linseed
1 Shilajit/Fulvic Acid
1 hydroxychloroquine
1 Salvia officinalis
1 Lemon Balm/Melissa officinalis
1 Ginger/6-Shogaol/Gingerol
1 Helleborus niger extracts – Christmas Rose
1 Inositol
1 iodine
1 phytic acid, Inositol hexakisphosphate
1 carboplatin
1 isoflavones
1 itraconazole
1 Geldanamycin
1 Lemongrass Extract/Citral
1 SDG/lignans
1 1,8-Cineole
1 Lutein
1 methylseleninic acid
1 Moringin
1 Methylglyoxal
1 Mushroom Maitake
1 Bicarbonate(Sodium)
1 No Product/Mechanism Only
1 Oleuropein
1 temozolomide
1 Pterostilbene
1 Rauwolfia serpentina/Indian Snakeroot
1 Oxaliplatin
1 Sanguinarine
1 α-Santalol/Sandalwood oil
1 Sulfasalazine
1 polyethylene glycol
1 Sesamin
1 Lignans
1 Terpinen-4-ol / Tea Tree Oil
1 Aflavin-3,3′-digallate
1 Vitamin B1/Thiamine
1 Vitamin B5,Pantothenic Acid
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:197  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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