TumCCA Cancer Research Results

TumCCA, Tumor cell cycle arrest: Click to Expand ⟱
Source:
Type:
Tumor cell cycle arrest refers to the process by which cancer cells stop progressing through the cell cycle, which is the series of phases that a cell goes through to divide and replicate. This arrest can occur at various checkpoints in the cell cycle, including the G1, S, G2, and M phases. S, G1, G2, and M are the four phases of mitosis.
Scientific Papers found: Click to Expand⟱
5018- UA,    Ursolic acid in cancer prevention and treatment: Molecular targets, pharmacokinetics and clinical studies
- Review, Var, NA
Inflam↓, TumCCA↑, chemoPv↑, TumMeta↓, antiOx↑, AntiViral↑, AntiDiabetic↑,
5020- UA,    Anticancer activity of ursolic acid on human ovarian cancer cells via ROS and MMP mediated apoptosis, cell cycle arrest and downregulation of PI3K/AKT pathway
- in-vitro, Ovarian, NA
tumCV↓, selectivity↑, BAX↑, Bcl-2↓, Apoptosis↑, ROS↑, TumCCA↑, Akt↓, PI3K↓,
5021- UA,    Anticancer effect of ursolic acid via mitochondria-dependent pathways
- Review, Var, NA
Inflam↓, TNF-α↓, IL6↓, IL17↓, NF-kB↓, COX2↓, *AntiDiabetic↑, *hepatoP↑, ALAT↓, AST↓, TumCP↓, Apoptosis↑, TumCCA↑, TumAuto↑, tumCV↓, TumCMig↓, Glycolysis↓, ATP↓, lactateProd↓, HK2↓, PKA↓, COX2↓, mtDam↑, Casp3↑, Casp8↑, Casp9↑, Akt↓, ROS↑, MMP↓, P53↑,
3790- UA,    Therapeutic applications of ursolic acid: a comprehensive review and utilization of predictive tools
*Inflam↓, *antiOx↑, AntiCan↑, *neuroP↑, *hepatoP↑, *cardioP↑, *MMP↑, *ROS↓, *PGC-1α↑, *BDNF↑, *cognitive↑, Bcl-2↓, Cyt‑c↑, DR5↑, Casp9↑, Casp8↑, Casp3↑, TumCCA↑, *BioAv↓, *Dose↝, *Half-Life↓, *Half-Life↓,
4857- Uro,    Evaluation and comparison of the anti-proliferative and anti-metastatic effects of urolithin A and urolithin B against esophageal cancer cells: an in vitro and in silico study
- in-vitro, ESCC, KYSE-30
tumCV↓, selectivity↑, TumCCA↑, ROS↑, Bcl-2↓, BAX↑, P21↑, MMP2↓, MMP9↓,
4833- Uro,    Unveiling the potential of Urolithin A in Cancer Therapy: Mechanistic Insights to Future Perspectives of Nanomedicine
- Review, Var, NA - Review, AD, NA - Review, IBD, NA
BioAv↝, TumAuto↝, TumCG↓, TumMeta↓, ChemoSen↑, Imm↑, RadioS↑, BioAv↑, other↝, eff↓, *antiOx↓, *Inflam↓, AntiCan↓, AntiAge↑, chemoP↑, *neuroP↑, *ROS↓, *cognitive↑, *lipid-P↓, *cardioP↑, *TNF-α↓, *IL6↓, GutMicro↑, TumCCA↑, Apoptosis↑, angioG↓, NF-kB↓, PI3K↓, Akt↓, Casp↑, survivin↓, TumCP↓, cycD1/CCND1↓, cMyc↑, BAX↑, Bcl-2↓, COX2↓, P53↑, p38↑, *ROS↓, *SOD↑, *GPx↑, SIRT1↑, FOXO1↑, eff↑, ChemoSen↑,
4835- Uro,    Urolithin A, induces apoptosis and autophagy crosstalk in Oral Squamous Cell Carcinoma via mTOR /AKT/ERK1/2 pathway
- in-vitro, SCC, NA
TumCD↑, ER Stress↑, Akt↓, mtDam↓, p‑mTOR↓, *BioAv↝, ROS↑, TumCCA↑, Apoptosis↑, ERK↓,
4837- Uro,    Urolithins: The Gut Based Polyphenol Metabolites of Ellagitannins in Cancer Prevention, a Review
- Review, Var, NA
AntiCan↑, TumCCA↑, Apoptosis↑, TumAuto↑, *BioAv↝, *BioAv↑, RAS↓, ERK↓, AR↓, TumCP↓, PI3K↓, Akt↓, NF-kB↓, COX2↓, IL6↓, IL1β↓, Wnt↓, β-catenin/ZEB1↓, cMyc↓, P53↑, Casp3↑, PARP↑, ROS↓, toxicity↓,
4841- Uro,    Urolithin A induces cell cycle arrest and apoptosis by inhibiting Bcl-2, increasing p53-p21 proteins and reactive oxygen species production in colorectal cancer cells
- in-vitro, CRC, HT29 - in-vitro, CRC, SW480 - in-vitro, CRC, SW-620
TumCP↓, TumCCA↑, Apoptosis↑, P53↑, P21↑, Bcl-2↓, Cyt‑c↑, Casp↑, ROS↑, *ROS↓,
4845- Uro,    The gut microbiota metabolite urolithin A, but not other relevant urolithins, induces p53-dependent cellular senescence in human colon cancer cells
- in-vitro, Colon, HCT116
TumCCA↑, P53↑, P21↑,
4847- Uro,    Metabolite of ellagitannins, urolithin A induces autophagy and inhibits metastasis in human sw620 colorectal cancer cells
- in-vitro, CRC, SW-620
TumCP↓, TumCMig↓, MMP9↓, TumAuto↑, Apoptosis↑, TumCCA↓, TumMeta↓, ChemoSen↓,
4852- Uro,    Dietary Urolithin B Suppresses Lung Tumorigenesis Correlating with Autophagy Induction and Gut Microbiota Remodeling
- vitro+vivo, Lung, NA
TumCG↓, *GutMicro↑, *Inflam↓, *antiOx↑, AntiTum↑, TumCCA↑, Apoptosis↑,
4855- Uro,    Urolithins impair cell proliferation, arrest the cell cycle and induce apoptosis in UMUC3 bladder cancer cells
- in-vitro, Bladder, UMUC3
TumCCA↑, PI3K↓, Akt↓, MAPK↓,
631- VitC,    Vitamin C preferentially kills cancer stem cells in hepatocellular carcinoma via SVCT-2
- vitro+vivo, Liver, NA
SVCT-2∅, ROS↑, DNAdam↑, ATP↓, TumCCA↑, Apoptosis↑, OS↑, CD133↓, EpCAM↓, OV6↓, γH2AX↑,
3132- VitC,    Vitamin C affects G0/G1 cell cycle and autophagy by downregulating of cyclin D1 in gastric carcinoma cells
- in-vitro, GC, MKN45
TumCCA↑, cycD1/CCND1↓,
1216- VitC,    Ascorbic acid induces ferroptosis via STAT3/GPX4 signaling in oropharyngeal cancer
- in-vitro, Laryn, FaDu - in-vitro, SCC, SCC-154
Iron↝, ROS↑, tumCV↓, Ki-67↓, TumCCA↑, Ferroptosis↑, GSH↓, ROS↑, MDA↑, STAT3↓, GPx4↓, p‑STAT3↓,
1817- VitK2,    Research progress on the anticancer effects of vitamin K2
- Review, Var, NA
TumCCA↑, Apoptosis↑, TumAuto↑, TumCI↓, TumCG↓, ChemoSen↓, ChemoSideEff↓, toxicity∅, eff↑, cycD1/CCND1↓, CDK4↓, eff↑, IKKα↓, NF-kB↓, other↑, p27↑, cMyc↓, i-ROS↑, Bcl-2↓, BAX↑, p38↑, MMP↓, Casp9↑, p‑ERK↓, RAS↓, MAPK↓, p‑P53↑, Casp8↑, Casp3↑, cJun↑, MMPs↓, eff↑, eff↑,
1824- VitK2,    Vitamin K and its analogs: Potential avenues for prostate cancer management
- Review, Pca, NA
AntiCan↑, toxicity∅, Risk↓, Apoptosis↑, ROS↑, TumCCA↑, eff↑, DNAdam↑, MMP↓, Cyt‑c↑, pro‑Casp3↑, FasL↑, Fas↑, TumAuto↑, ChemoSen↑, RadioS↑,
1816- VitK2,    Role of Vitamin K in Selected Malignant Neoplasms in Women
- Review, Var, NA
TumCP↓, TumMeta↓, TumAuto↑, Apoptosis↑, Apoptosis↑, Casp3↑, Casp7↑, ROS↑, AR↓, EMT↓, Wnt↓, MMP↓, Cyt‑c↑, NF-kB↓, cycD1/CCND1↓, TumCCA↓,
1822- VitK2,    Vitamin K: A novel cancer chemosensitizer
- Review, Var, NA
ChemoSen↑, Apoptosis↑, TumCCA↑, P-gp↓,
1823- VitK2,  VitK3,    Vitamins K2, K3 and K5 exert antitumor effects on established colorectal cancer in mice by inducing apoptotic death of tumor cells
- in-vitro, CRC, NA - in-vivo, NA, NA
TumCP↓, TumCCA↑, Casp3↑,
1820- VitK3,    Vitamin K3 (menadione) suppresses epithelial-mesenchymal-transition and Wnt signaling pathway in human colorectal cancer cells
- in-vitro, CRC, SW480 - in-vitro, CRC, SW-620
selectivity↑, TumCI↓, TumCMig↓, EMT↓, E-cadherin↑, ZO-1↑, N-cadherin↓, Vim↓, Zeb1↓, MMP2↓, MMP9↓, TOPflash↓, β-catenin/ZEB1↓, p300↓, cycD1/CCND1↓, TumCCA↑,
1839- VitK3,    Vitamin K3 derivative inhibits androgen receptor signaling in targeting aggressive prostate cancer cells
- in-vitro, Pca, NA
TumCP↓, Apoptosis↑, TumCCA↑, ROS↑, eff↓, AR↓, Trx↓, Bcl-2↓,

Showing Research Papers: 701 to 723 of 723
Prev Page 15 of 15

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 723

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,   Ferroptosis↑, 1,   GPx4↓, 1,   GSH↓, 1,   Iron↝, 1,   MDA↑, 1,   ROS↓, 1,   ROS↑, 11,   i-ROS↑, 1,   Trx↓, 1,  

Mitochondria & Bioenergetics ⓘ

ATP↓, 2,   MMP↓, 4,   mtDam↓, 1,   mtDam↑, 1,  

Core Metabolism/Glycolysis ⓘ

ALAT↓, 1,   cMyc↓, 2,   cMyc↑, 1,   Glycolysis↓, 1,   HK2↓, 1,   lactateProd↓, 1,   SIRT1↑, 1,  

Cell Death ⓘ

Akt↓, 6,   Apoptosis↑, 15,   BAX↑, 4,   Bcl-2↓, 7,   Casp↑, 2,   Casp3↑, 6,   pro‑Casp3↑, 1,   Casp7↑, 1,   Casp8↑, 3,   Casp9↑, 3,   Cyt‑c↑, 4,   DR5↑, 1,   Fas↑, 1,   FasL↑, 1,   Ferroptosis↑, 1,   MAPK↓, 2,   p27↑, 1,   p38↑, 2,   survivin↓, 1,   TumCD↑, 1,  

Transcription & Epigenetics ⓘ

cJun↑, 1,   other↑, 1,   other↝, 1,   OV6↓, 1,   tumCV↓, 4,  

Protein Folding & ER Stress ⓘ

ER Stress↑, 1,  

Autophagy & Lysosomes ⓘ

TumAuto↑, 6,   TumAuto↝, 1,  

DNA Damage & Repair ⓘ

DNAdam↑, 2,   P53↑, 5,   p‑P53↑, 1,   PARP↑, 1,   γH2AX↑, 1,  

Cell Cycle & Senescence ⓘ

CDK4↓, 1,   cycD1/CCND1↓, 5,   P21↑, 3,   TumCCA↓, 2,   TumCCA↑, 21,  

Proliferation, Differentiation & Cell State ⓘ

CD133↓, 1,   EMT↓, 2,   EpCAM↓, 1,   ERK↓, 2,   p‑ERK↓, 1,   FOXO1↑, 1,   p‑mTOR↓, 1,   p300↓, 1,   PI3K↓, 4,   RAS↓, 2,   STAT3↓, 1,   p‑STAT3↓, 1,   TOPflash↓, 1,   TumCG↓, 3,   Wnt↓, 2,  

Migration ⓘ

E-cadherin↑, 1,   Ki-67↓, 1,   MMP2↓, 2,   MMP9↓, 3,   MMPs↓, 1,   N-cadherin↓, 1,   PKA↓, 1,   TumCI↓, 2,   TumCMig↓, 3,   TumCP↓, 8,   TumMeta↓, 4,   Vim↓, 1,   Zeb1↓, 1,   ZO-1↑, 1,   β-catenin/ZEB1↓, 2,  

Angiogenesis & Vasculature ⓘ

angioG↓, 1,  

Barriers & Transport ⓘ

P-gp↓, 1,   SVCT-2∅, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 4,   IKKα↓, 1,   IL17↓, 1,   IL1β↓, 1,   IL6↓, 2,   Imm↑, 1,   Inflam↓, 2,   NF-kB↓, 5,   TNF-α↓, 1,  

Hormonal & Nuclear Receptors ⓘ

AR↓, 3,  

Drug Metabolism & Resistance ⓘ

BioAv↑, 1,   BioAv↝, 1,   ChemoSen↓, 2,   ChemoSen↑, 4,   eff↓, 2,   eff↑, 6,   RadioS↑, 2,   selectivity↑, 3,  

Clinical Biomarkers ⓘ

ALAT↓, 1,   AR↓, 3,   AST↓, 1,   GutMicro↑, 1,   IL6↓, 2,   Ki-67↓, 1,  

Functional Outcomes ⓘ

AntiAge↑, 1,   AntiCan↓, 1,   AntiCan↑, 3,   AntiDiabetic↑, 1,   AntiTum↑, 1,   chemoP↑, 1,   chemoPv↑, 1,   ChemoSideEff↓, 1,   OS↑, 1,   Risk↓, 1,   toxicity↓, 1,   toxicity∅, 2,  

Infection & Microbiome ⓘ

AntiViral↑, 1,  
Total Targets: 129

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↓, 1,   antiOx↑, 2,   GPx↑, 1,   lipid-P↓, 1,   ROS↓, 4,   SOD↑, 1,  

Mitochondria & Bioenergetics ⓘ

MMP↑, 1,   PGC-1α↑, 1,  

Immune & Inflammatory Signaling ⓘ

IL6↓, 1,   Inflam↓, 3,   TNF-α↓, 1,  

Synaptic & Neurotransmission ⓘ

BDNF↑, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 1,   BioAv↑, 1,   BioAv↝, 2,   Dose↝, 1,   Half-Life↓, 2,  

Clinical Biomarkers ⓘ

GutMicro↑, 1,   IL6↓, 1,  

Functional Outcomes ⓘ

AntiDiabetic↑, 1,   cardioP↑, 2,   cognitive↑, 2,   hepatoP↑, 2,   neuroP↑, 2,  
Total Targets: 24

Scientific Paper Hit Count for: TumCCA, Tumor cell cycle arrest
35 Curcumin
31 Quercetin
29 Silver-NanoParticles
25 Thymoquinone
24 Sulforaphane (mainly Broccoli)
22 Apigenin (mainly Parsley)
22 Berberine
17 Phenethyl isothiocyanate
16 Baicalein
15 Artemisinin
15 Capsaicin
15 Fisetin
15 Piperlongumine
14 Shikonin
12 Magnetic Fields
12 Ashwagandha(Withaferin A)
12 EGCG (Epigallocatechin Gallate)
12 Betulinic acid
12 Resveratrol
11 Radiotherapy/Radiation
11 Chrysin
11 Emodin
11 Magnolol
11 Lycopene
10 Propolis -bee glue
10 Garcinol
10 Honokiol
9 Rosmarinic acid
9 Graviola
9 Silymarin (Milk Thistle) silibinin
9 Urolithin
8 Allicin (mainly Garlic)
8 Cisplatin
8 Carvacrol
8 Ellagic acid
8 Luteolin
7 Chemotherapy
7 chitosan
7 Phenylbutyrate
7 Pterostilbene
6 5-fluorouracil
6 doxorubicin
6 Astaxanthin
6 Berbamine
6 Boswellia (frankincense)
6 Celastrol
6 Naringin
6 Selenite (Sodium)
5 Bufalin/Huachansu
5 Boron
5 Caffeic Acid Phenethyl Ester (CAPE)
5 Chlorogenic acid
5 Paclitaxel
5 Plumbagin
5 salinomycin
5 Ursolic acid
5 Vitamin K2
4 Coenzyme Q10
4 Vitamin C (Ascorbic Acid)
4 Brucea javanica
4 Caffeic acid
4 Thymol-Thymus vulgaris
4 Selenium
4 HydroxyTyrosol
4 Juglone
4 Laetrile B17 Amygdalin
4 VitK3,menadione
4 Selenium NanoParticles
4 Aflavin-3,3′-digallate
3 Astragalus
3 Copper and Cu NanoParticles
3 Alpha-Lipoic-Acid
3 Andrographis
3 Gemcitabine (Gemzar)
3 Biochanin A
3 borneol
3 Bruteridin(bergamot juice)
3 Carnosic acid
3 Celecoxib
3 Date Fruit Extract
3 Piperine
3 Ferulic acid
3 Gallic acid
3 Gambogic Acid
3 Genistein (soy isoflavone)
3 Hydroxycinnamic-acid
3 Metformin
3 Magnetic Field Rotating
3 Propyl gallate
3 Parthenolide
2 Glucose
2 Gold NanoParticles
2 Photodynamic Therapy
2 Ascorbyl Palmitate
2 Melatonin
2 Atorvastatin
2 beta-glucans
2 Baicalin
2 Bacopa monnieri
2 Butyrate
2 Zinc
2 Chlorophyllin
2 Dichloroacetate
2 Deguelin
2 diet Methionine-Restricted Diet
2 Electrical Pulses
2 carboplatin
2 Hyperthermia
2 itraconazole
2 Licorice
2 Methylene blue
2 Magnesium
2 Oleuropein
1 tamoxifen
1 Ajoene (compound of Garlic)
1 alpha Linolenic acid
1 dibenzyl trisulphide(DTS) from Anamu
1 Arctigenin
1 Aloe anthraquinones
1 immunotherapy
1 D-limonene
1 epirubicin
1 brusatol
1 Bromelain
1 Carnosine
1 Selenate
1 Docetaxel
1 Chocolate
1 Vitamin E
1 Docosahexaenoic Acid
1 diet FMD Fasting Mimicking Diet
1 Disulfiram
1 Evodiamine
1 Citric Acid
1 Sorafenib (brand name Nexavar)
1 Fenbendazole
1 Shilajit/Fulvic Acid
1 Galloflavin
1 Rapamycin
1 Inositol
1 Methylglyoxal
1 Methylsulfonylmethane
1 Mushroom Chaga
1 Myricetin
1 Niclosamide (Niclocide)
1 Proanthocyanidins
1 Sanguinarine
1 Psoralidin
1 Kaempferol
1 Rutin
1 Oxaliplatin
1 Sulfasalazine
1 Auranofin
1 Salvia miltiorrhiza
1 Spermidine
1 Osimertinib
1 Adagrasib
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:322  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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