TumCG Cancer Research Results

TumCG, Tumor cell growth: Click to Expand ⟱
Source:
Type:
Normal cells grow and divide in a regulated manner through the cell cycle, which consists of phases (G1, S, G2, and M).
Cancer cells often bypass these regulatory mechanisms, leading to uncontrolled proliferation. This can result from mutations in genes that control the cell cycle, such as oncogenes (which promote cell division) and tumor suppressor genes (which inhibit cell division).
Scientific Papers found: Click to Expand⟱
94- QC,  HPT,    Effects of quercetin on the heat-induced cytotoxicity of prostate cancer cells
- in-vitro, Pca, LNCaP - in-vitro, Pca, PC3 - in-vitro, Pca, JCA-1
HSP70/HSPA5↓, TumCCA↑, TumCG↓, eff↑,
99- QC,    Quercetin Inhibits Epithelial-to-Mesenchymal Transition (EMT) Process and Promotes Apoptosis in Prostate Cancer via Downregulating lncRNA MALAT1
- in-vitro, Pca, PC3
EMT↓, E-cadherin↑, N-cadherin↓, Ki-67↓, PI3K/Akt↓, MALAT1↓, TumCG↓,
88- QC,  PacT,    Quercetin Enhanced Paclitaxel Therapeutic Effects Towards PC-3 Prostate Cancer Through ER Stress Induction and ROS Production
- vitro+vivo, Pca, PC3
ROS↑, ER Stress↑, TumCP↓, Apoptosis↑, TumCCA↑, TumCMig↓, GRP78/BiP↑, CHOP/DDIT3↑, TumCG↓,
77- QC,  EGCG,    The dietary bioflavonoid quercetin synergizes with epigallocathechin gallate (EGCG) to inhibit prostate cancer stem cell characteristics, invasion, migration and epithelial-mesenchymal transition
- in-vitro, Pca, CD44+ - in-vitro, NA, CD133+ - in-vitro, NA, PC3 - in-vitro, NA, LNCaP
Casp3↑, Casp7↑, Bcl-2↓, survivin↓, XIAP↓, EMT↓, Vim↓, Slug↓, Snail↓, β-catenin/ZEB1↓, LEF1↓, TCF↓, eff↑, CSCs↓, TumCG↓, tumCV↓,
911- QC,  SFN,    Pilot study evaluating broccoli sprouts in advanced pancreatic cancer (POUDER trial) - study protocol for a randomized controlled trial
TumCG↓, Risk↓,
156- Ralox,  Tam,  GEN,  CUR,    Modulators of estrogen receptor inhibit proliferation and migration of prostate cancer cells
- in-vitro, Pca, DU145 - in-vitro, Pca, PC3
ERβ/ESR2↑, TumCG↓, TumCMig↓, FAK↓, p38↓,
2332- RES,    Resveratrol’s Anti-Cancer Effects through the Modulation of Tumor Glucose Metabolism
- Review, Var, NA
Glycolysis↓, GLUT1↓, PFK1↓, Hif1a↓, ROS↑, PDH↑, AMPK↑, TumCG↓, TumCI↓, TumCP↓, p‑NF-kB↓, SIRT1↑, SIRT3↑, LDH↓, PI3K↓, mTOR↓, PKM2↓, R5P↝, G6PD↓, TKT↝, talin↓, HK2↓, GRP78/BiP↑, GlucoseCon↓, ER Stress↑, Warburg↓, PFK↓,
2440- RES,    Resveratrol inhibits Hexokinases II mediated glycolysis in non-small cell lung cancer via targeting Akt signaling pathway
- in-vitro, Lung, H460 - in-vivo, Lung, NA - in-vitro, Lung, H1650 - in-vitro, Lung, HCC827
AntiTum↑, Glycolysis↓, HK2↓, EGFR↓, Akt↓, ERK↓, GlucoseCon↓, lactateProd↓, TumCG↓, Ki-67↓,
3097- RES,    Resveratrol Induces Notch2-mediated Apoptosis and Suppression of Neuroendocrine Markers in Medullary Thyroid Cancer
- in-vitro, Thyroid, TT
TumCG↓, cl‑Casp3↑, p‑PARP↑, NOTCH2↑,
3052- RES,    Resveratrol-Induced Downregulation of NAF-1 Enhances the Sensitivity of Pancreatic Cancer Cells to Gemcitabine via the ROS/Nrf2 Signaling Pathways
- in-vitro, PC, PANC1 - in-vitro, PC, MIA PaCa-2 - in-vitro, PC, Bxpc-3
NAF1↓, ROS↑, NRF2↑, eff↑, TumCG↓,
3054- RES,    Resveratrol induced reactive oxygen species and endoplasmic reticulum stress-mediated apoptosis, and cell cycle arrest in the A375SM malignant melanoma cell line
- in-vitro, Melanoma, A375
TumCG↓, P21↑, p27/CDKN1B↑, CycB/CCNB1↓, ROS↑, ER Stress↑, p‑p38↑, P53↑, p‑eIF2α↑, EP4/PTGER4↑, CHOP/DDIT3↑, Bcl-2↓, BAX↓, TumCCA↑, NRF2↓, ChemoSen↑, GSH↓,
885- RES,    Resveratrol induces intracellular Ca2 + rise via T-type Ca2 + channels in a mesothelioma cell line
- in-vitro, RCC, REN - in-vitro, Nor, MeT5A
TumCG↓, Ca+2↑, *toxicity↓,
993- RES,    Resveratrol reverses the Warburg effect by targeting the pyruvate dehydrogenase complex in colon cancer cells
- in-vitro, CRC, Caco-2 - in-vivo, Nor, HCEC 1CT
TumCG↓, Glycolysis↓, PPP↓, ATP↑, PDH↑, Ca+2↝, TumCP↓, lactateProd↓, OCR↑, ECAR↓, *ECAR∅, *other?, cycE/CCNE↑, cycA1/CCNA1↑, TumCCA↑, cycD1/CCND1↑, OXPHOS↑,
6808- RF,    Safety and Efficacy of amplitude-modulated radiofrequency electromagnetic fields in advanced hepatocellular carcinoma
- Trial, HCC, NA
OS↑, *toxicity↓, Dose↝, TumCG↓, Dose↝, Dose↝, Dose↝, eff↑,
6807- RF,    Tumour-specific amplitude-modulated radiofrequency electromagnetic fields induce differentiation of hepatocellular carcinoma via targeting Cav3.2 T-type voltage-gated calcium channels and Ca2+ influx
- NA, HCC, NA
TumVol↓, Ca+2↑, TumCG↓, Dose↝,
3010- RosA,    Exploring the mechanism of rosmarinic acid in the treatment of lung adenocarcinoma based on bioinformatics methods and experimental validation
- in-vitro, Lung, A549 - in-vivo, NA, NA
TumCG↓, Ki-67↓, FABP4↑, PPARα↑, ROS↑, Apoptosis↑, MMP9↓, IGFBP3↓, MMP2↓, EMT↓, TumCI↓, PI3K↓, Akt↓, mTOR↓, Gli1↓, PPARγ↑, Cyt‑c↑,
3006- RosA,    Rosmarinic acid attenuates glioblastoma cells and spheroids’ growth and EMT/stem-like state by PTEN/PI3K/AKT downregulation and ERK-induced apoptosis
- in-vitro, GBM, U87MG - in-vitro, GBM, LN229
TumCG↓, EMT↓, SIRT1↓, FOXO1↓, NF-kB↓, angioG↓, ROS↓, PTEN↓, PI3K↓, Akt↓, *Inflam↓, *cardioP↑, *hepatoP↑, *neuroP↑, Warburg↓,
3003- RosA,    Comprehensive Insights into Biological Roles of Rosmarinic Acid: Implications in Diabetes, Cancer and Neurodegenerative Diseases
- Review, Var, NA - Review, AD, NA - Review, Park, NA
*Inflam↓, *antiOx↑, *neuroP↑, *IL6↓, *IL1β↓, *NF-kB↓, *PGE2↓, *COX2/PTGS2↓, *MMP↑, *memory↑, *ROS↓, *Aβ↓, *HMGB1↓, TumCG↓, MARK4↓, Zeb1↓, MDM2↓, BNIP3↑, ASC↑, NLRP3↓, PI3K↓, Akt↓, Casp1↓, E-cadherin↑, STAT3↓, TLR4↓, MMP↓, ICAM-1↓, AMPK↓, IL6↑, MMP2↓, Warburg↓, Bcl-xL↓, Bcl-2↓, TumCCA↑, EMT↓, TumMeta↓, mTOR↓, HSP27↓, Casp3↑, GlucoseCon↓, lactateProd↓, VEGF↓, p‑p65↓, GIT1↓, FOXM1↓, cycD1/CCND1↓, CDK4↓, MMP9↓, HDAC2↓,
3002- RosA,    Anticancer Effects of Rosemary (Rosmarinus officinalis L.) Extract and Rosemary Extract Polyphenols
- Review, Var, NA
TumCG↓, TumCP↓, TumCCA↑, ChemoSen↑, NRF2↑, PERK↑, SESN2↑, HO-1↑, cl‑Casp3↑, ROS↑, UPR↑, ER Stress↑, CHOP/DDIT3↑, HER2/EBBR2↓, ER-α36↓, PSA↓, BAX↑, AR↓, P-gp/ABCB1↓, Cyt‑c↑, HSP70/HSPA5↑, eff↑, p‑Akt↓, p‑mTOR↓, p‑P70S6K↓, cl‑PARP↑, eff↑,
3037- RosA,    Unraveling rosmarinic acid anticancer mechanisms in oral cancer malignant transformation
- in-vitro, Oral, SCC9 - in-vitro, Oral, HSC3
survivin↓, AntiCan↑, Vim↓, Snail↓, SOX9↓, EMT↓, MMP2↓, MMP9↓, P-gp/ABCB1↓, TumCG↓, ROS↑, MMP↓, GSH↓, P-gp/ABCB1↓, ATP↓,
3033- RosA,    Rosemary (Rosmarinus officinalis) Extract Modulates CHOP/GADD153 to Promote Androgen Receptor Degradation and Decreases Xenograft Tumor Growth
- in-vitro, Pca, 22Rv1 - in-vitro, Pca, LNCaP - vitro+vivo, NA, NA
ER Stress↑, selectivity↑, AR↓, TumCG↓, TumCCA↑, CHOP/DDIT3↑, PERK↓, GRP78/BiP↑, PSA↓,
3639- Sage,    Pharmacological properties of Salvia officinalis and its components
- Review, AD, NA - Review, Var, NA
AntiCan↑, *Inflam↓, *antiOx↑, *cognitive↑, *memory↑, *LDL↓, TumCG↓, MAPK↓, ROS↓, NF-kB↓, COX2/PTGS2↓, angioG↓, *AST↓, *ALAT?,
2040- SAHA,    The histone deacetylase inhibitor SAHA arrests cancer cell growth, up-regulates thioredoxin-binding protein-2, and down-regulates thioredoxin
- in-vitro, Pca, LNCaP - in-vitro, CRC, T24/HTB-9 - in-vitro, BC, MCF7
HDAC↓, TumCG↓, Diff↑, Apoptosis↑, TXNIP↑,
4900- Sal,    Anticancer Mechanisms of Salinomycin in Breast Cancer and Its Clinical Applications
- Review, BC, NA
CSCs↓, Apoptosis↑, TumAuto↑, necrosis↑, TumCP↓, TumCI↓, TumCMig↓, TumCG↓, TumMeta↓, eff↑, Bcl-2↓, cMyc↓, Snail↓, ALDH↓, Myc↓, AR↓, ROS↑, NF-kB↓, PTCH1↓, Smo↓, Gli1↓, GLI2↓, Wnt↓, mTOR↓, GSK‐3β↓, cycD1/CCND1↓, survivin↓, P21↑, p27/CDKN1B↑, CHOP/DDIT3↑, Ca+2↑, DNAdam↑, Hif1a↓, VEGF↓, angioG↓, MMP↓, ATP↓, p‑P53↑, γH2AX↑, ChemoSen↑,
4902- Sal,  OXA,    Salinomycin and oxaliplatin synergistically enhances cytotoxic effect on human colorectal cancer cells in vitro and in vivo
- vitro+vivo, CRC, NA
RadioS↑, ChemoSen↑, TumCP↓, Apoptosis↑, ROS↑, MMP↓, MAPK↑, eff↓, TumCG↓, TumCCA↑,
4903- Sal,    Salinomycin: A new paradigm in cancer therapy
- Review, Var, NA
TumCG↓, ATP↓, CSCs↓, ROS↑, Casp↑, MMP↓, selectivity↑, OXPHOS↓, STAT3↓, P53↑, γH2AX↑, cycD1/CCND1↓, TumCCA↑, DNAdam↑, ChemoSen↑,
4995- Sal,    Salinomycin possesses anti-tumor activity and inhibits breast cancer stem-like cells via an apoptosis-independent pathway
- vitro+vivo, BC, MDA-MB-231
ALDH↓, Nanog↓, OCT4↓, SOX2↓, CSCs↓, tumCV↓, cycD1/CCND1↓, P21↑, TumCG↓, CD44↓, Apoptosis∅,
4909- Sal,    Salinomycin: Anti-tumor activity in a pre-clinical colorectal cancer model
- vitro+vivo, CRC, NA
AntiTum↑, Apoptosis↑, mtDam↑, ROS↑, SOD1↓, ChemoSen↑, CSCs↑, ALDH↓, TumCG↓, TumCP↓, TumCD↑, ATP↓,
5123- Sal,    Salinomycin suppresses LRP6 expression and inhibits both Wnt/β-catenin and mTORC1 signaling in breast and prostate cancer cells
- in-vitro, BC, MCF7 - in-vitro, Pca, PC3 - in-vitro, Pca, DU145 - in-vitro, BC, MDA-MB-231 - in-vitro, Nor, HEK293
Wnt↓, β-catenin/ZEB1↓, mTORC1↓, GSK‐3β↑, cycD1/CCND1↓, survivin↓, LRP6↓, TumCG↓, Apoptosis↑,
5122- Sal,    Identification of selective inhibitors of cancer stem cells by high-throughput screening
- in-vivo, BC, SUM159 - NA, NA, 4T1
CSCs↓, TumCG↓, Diff↑, selectivity↑, CD44↓, CD24↓, TumVol↓,
6440- SAO,    Biological Properties of Sandalwood Oil and Microbial Synthesis of Its Major Sesquiterpenoids
- Review, Var, NA
AntiCan↑, *Bacteria↓, *antiOx↑, *Inflam↓, *ROS↓, AntiTum↑, TumCG↓, tumCV↓, β-catenin/ZEB1↓, TumCMig↓, chemoPv↑,
6441- SAO,    Sandalwood Album Oil as a Botanical Therapeutic in Dermatology
- Review, PSA, NA
*Inflam↓, *eff↑, *5LO↓, *DPPH↓, *hepatoP↑, *ROS↓, *PGE2↓, *IL1β↓, *IL17↓, *PDE4↓, *tyrosinase↓, *AntiFungal↑, angioG↓, TumCG↓, DNAdam↑, *Snail↑, *Twist↑, *Vim↑, *EMT↓, *toxicity↓,
6442- SAO,    Medicinal properties of alpha-santalol, a naturally occurring constituent of sandalwood oil: review
- Review, RCC, NA
AntiTum↑, Apoptosis↑, TumCCA↑, *Inflam↓, selectivity↑, tumCV↓, Casp8↓, Casp9↓, Casp6↓, Casp3↓, cl‑PARP↑, angioG↓, VEGFR2/KDR/Flk1↓, Akt↑, mTOR↓, TumCG↓, *GSTs↑, *antiOx↑, *ROS↓,
6443- SAO,    α-Santalol, a derivative of sandalwood oil, induces apoptosis in human prostate cancer cells by causing caspase-3 activation
- in-vitro, Pca, PC3
tumCV↓, Apoptosis↑, DNAdam↑, Casp3↑, cl‑PARP↑, TumCG↓,
6449- SAO,    Skin cancer chemoprevention by α-santalol
- Review, Melanoma, A431
*chemoPv↑, Apoptosis↑, Casp↑, MMP↓, Cyt‑c↑, TumCCA↑, TumCG↓,
6451- SAO,    α-Santalol functionalized chitosan nanoparticles as efficient inhibitors of polo-like kinase in triple negative breast cancer
- vitro+vivo, BC, MDA-MB-231
TumCP↓, selectivity↑, Bcl-2↓, PLK1↓, BAD↑, Casp↑, BAX↑, Dose↝, TumCG↓,
5044- SAS,    xCT inhibitor sulfasalazine depletes paclitaxel-resistant tumor cells through ferroptosis in uterine serous carcinoma
- in-vitro, Var, NA
xCT/SLC7A11↓, Ferroptosis↑, ROS↑, IL1↓, IL2↓, NF-kB↓, GSH↓, TumCG↓, ChemoSen↑,
5042- SAS,    xCT: A Critical Molecule That Links Cancer Metabolism to Redox Signaling
- Review, Var, NA
xCT/SLC7A11↓, GSH↓, TumCG↓, TumCI↓, ROS↑, RadioS↑, eff↓,
5041- SAS,  Cisplatin,    Xc− inhibitor sulfasalazine sensitizes colorectal cancer to cisplatin by a GSH-dependent mechanism
- in-vitro, CRC, NA
xCT/SLC7A11↓, Inflam↓, Apoptosis↓, GSH↓, ROS↑, TumCG↓, selectivity↑, eff↑, eff↓,
5039- SAS,    Regulatory network of ferroptosis and autophagy by targeting oxidative stress defense using sulfasalazine in triple-negative breast cancer
- vitro+vivo, BC, NA
xCT/SLC7A11↓, ROS↑, GSH↓, Ferroptosis↑, TumCG↓, toxicity↓, lipid-P↑,
5036- SAS,    Targeting xCT with sulfasalazine suppresses triple-negative breast cancer growth via inducing autophagy and coordinating cell cycle and proliferation
- vitro+vivo, BC, MDA-MB-231 - in-vitro, BC, MDA-MB-468
xCT/SLC7A11↓, GSH↓, OS↑, Myc↓, CDK1↓, CD44↓, eff↑, TumCG↓,
4486- Se,  Chit,    Selenium-Modified Chitosan Induces HepG2 Cell Apoptosis and Differential Protein Analysis
- in-vitro, Liver, HepG2
Apoptosis↑, TumCCA↑, MMP↓, Bcl-2↓, BAX↑, cl‑Casp9↑, cl‑Casp3↑, Risk↓, *BioAv↑, *toxicity↑, TumCG↓, AntiTum↑, ROS↑, Cyt‑c↑, Fas↑, FasL↑, FADD↑,
4734- SeNPs,  CPT-11,    Cytotoxicity and therapeutic effect of irinotecan combined with selenium nanoparticles
- in-vitro, CRC, HCT8 - in-vivo, NA, NA
chemoP↑, ChemoSen↑, P53↑, Apoptosis↑, TumCG↓, Casp↑, Dose↝, NRF2↓, selectivity↑, *NRF2↑,
4469- SeNPs,    Selenium Nanoparticles in Cancer Therapy: Unveiling Cytotoxic Mechanisms and Therapeutic Potential
- Review, Var, NA
antiOx↑, selectivity↑, eff↑, AntiCan↑, Apoptosis↑, ROS↑, MMP↓, Casp3↑, Casp9↑, AntiTum↑, TumCG↓, TumMeta↓, angioG↓, Cyt‑c↑, DNAdam↑, RadioS↑, BBB↑, *toxicity↓, ChemoSen↑,
3193- SFN,    Epigenetic Therapeutics Targeting NRF2/KEAP1 Signaling in Cancer Oxidative Stress
- Review, Var, NA
DNMTs↓, HDAC↑, NRF2↑, DNMT1↓, DNMT3A↓, NQO1↑, COMT↑, TumCG↓, *toxicity↓,
110- SFN,    Sulforaphane regulates self-renewal of pancreatic cancer stem cells through the modulation of Sonic hedgehog-GLI pathway
- in-vivo, PC, NA
HH↓, Smo↓, Gli1↓, GLI2↓, Shh↓, VEGF↓, PDGFRA↓, EMT↓, Zeb1↓, Bcl-2↓, XIAP↓, E-cadherin↑, OCT4↓, Nanog↓, TumCG↑,
2552- SFN,  Chemo,    Chemopreventive activity of sulforaphane
- Review, Var, NA
chemoPv↑, TumCG↓, *ROS↓, *Inflam↓, *Dose↝, *NRF2↑, *HO-1↑, *NQO1↑, NF-kB↓, ROS↑,
2448- SFN,    Sulforaphane and bladder cancer: a potential novel antitumor compound
- Review, Bladder, NA
Apoptosis↑, TumCG↓, TumCI↓, TumMeta↓, glucoNG↓, ChemoSen↑, TumCCA↑, Casp3↑, Casp7↑, cl‑PARP↑, survivin↓, EGFR↓, HER2/EBBR2↓, ATP↓, Glycolysis↓, mt-OXPHOS↓, AKT1↓, HK2↓, Hif1a↓, ROS↑, NRF2↑, EMT↓, COX2/PTGS2↓, MMP2↓, MMP9↓, Zeb1↓, Snail↓, HDAC↓, HATs↓, MMP↓, Cyt‑c↓, Shh↓, Smo↓, Gli1↓, BioAv↝, BioAv↝, Dose↝,
1469- SFN,    Sulforaphane enhances the therapeutic potential of TRAIL in prostate cancer orthotopic model through regulation of apoptosis, metastasis, and angiogenesis
- in-vitro, Pca, PC3 - in-vitro, Pca, LNCaP - in-vivo, Pca, NA
eff↑, ROS↑, MMP↓, Casp3↑, Casp9↑, DR4↑, DR5↑, BAX↑, Bak↑, BIM↑, NOXA↑, Bcl-2↓, Bcl-xL↓, Mcl-1↓, eff↓, TumCG↓, TumCP↓, eff↑, NF-kB↓, PI3K↓, Akt↓, MEK↓, ERK↓, angioG↓, FOXO3↑,
1466- SFN,    Sulforaphane inhibits thyroid cancer cell growth and invasiveness through the reactive oxygen species-dependent pathway
- vitro+vivo, Thyroid, FTC-133
TumCP↓, TumCCA↑, Apoptosis↑, TumCMig↓, TumCI↓, EMT↓, Slug↓, Twist↓, MMP2↓, MMP9↓, TumCG↓, p‑Akt↓, P21↑, ERK↑, p38↑, ROS↑, *toxicity∅, MMP↓, eff↓,

Showing Research Papers: 701 to 750 of 831
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 831

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   Ferroptosis↑, 2,   GSH↓, 7,   HO-1↑, 1,   lipid-P↑, 1,   NAF1↓, 1,   NQO1↑, 1,   NRF2↓, 2,   NRF2↑, 4,   OXPHOS↓, 1,   OXPHOS↑, 1,   mt-OXPHOS↓, 1,   ROS↓, 2,   ROS↑, 21,   SIRT3↑, 1,   SOD1↓, 1,   TKT↝, 1,   xCT/SLC7A11↓, 5,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↓, 5,   ATP↑, 1,   MEK↓, 1,   MMP↓, 11,   mtDam↑, 1,   OCR↑, 1,   XIAP↓, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AKT1↓, 1,   AMPK↓, 1,   AMPK↑, 1,   cMyc↓, 1,   ECAR↓, 1,   FABP4↑, 1,   G6PD↓, 1,   glucoNG↓, 1,   GlucoseCon↓, 3,   Glycolysis↓, 4,   HK2↓, 3,   lactateProd↓, 3,   LDH↓, 1,   PDH↑, 2,   PFK↓, 1,   PFK1↓, 1,   PI3K/Akt↓, 1,   PKM2↓, 1,   PPARα↑, 1,   PPARγ↑, 1,   PPP↓, 1,   R5P↝, 1,   SIRT1↓, 1,   SIRT1↑, 1,   Warburg↓, 3,  

Cell Death(tgid=5) ⓘ

Akt↓, 5,   Akt↑, 1,   p‑Akt↓, 2,   Apoptosis↓, 1,   Apoptosis↑, 15,   Apoptosis∅, 1,   BAD↑, 1,   Bak↑, 1,   BAX↓, 1,   BAX↑, 4,   Bcl-2↓, 8,   Bcl-xL↓, 2,   BIM↑, 1,   Casp↑, 4,   Casp1↓, 1,   Casp3↓, 1,   Casp3↑, 6,   cl‑Casp3↑, 3,   Casp6↓, 1,   Casp7↑, 2,   Casp8↓, 1,   Casp9↓, 1,   Casp9↑, 2,   cl‑Casp9↑, 1,   Cyt‑c↓, 1,   Cyt‑c↑, 5,   DR4↑, 1,   DR5↑, 1,   FADD↑, 1,   Fas↑, 1,   FasL↑, 1,   Ferroptosis↑, 2,   MAPK↓, 1,   MAPK↑, 1,   Mcl-1↓, 1,   MDM2↓, 1,   Myc↓, 2,   necrosis↑, 1,   NOXA↑, 1,   p27/CDKN1B↑, 2,   p38↓, 1,   p38↑, 1,   p‑p38↑, 1,   survivin↓, 5,   TumCD↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

HER2/EBBR2↓, 2,   SOX9↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

HATs↓, 1,   tumCV↓, 5,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 5,   p‑eIF2α↑, 1,   ER Stress↑, 5,   GRP78/BiP↑, 3,   HSP27↓, 1,   HSP70/HSPA5↓, 1,   HSP70/HSPA5↑, 1,   PERK↓, 1,   PERK↑, 1,   UPR↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

BNIP3↑, 1,   SESN2↑, 1,   TumAuto↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 5,   DNMT1↓, 1,   DNMT3A↓, 1,   DNMTs↓, 1,   P53↑, 3,   p‑P53↑, 1,   p‑PARP↑, 1,   cl‑PARP↑, 4,   γH2AX↑, 2,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1,   CDK4↓, 1,   cycA1/CCNA1↑, 1,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 5,   cycD1/CCND1↑, 1,   cycE/CCNE↑, 1,   P21↑, 4,   PLK1↓, 1,   TumCCA↑, 14,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 3,   CD24↓, 1,   CD44↓, 3,   CSCs↓, 5,   CSCs↑, 1,   Diff↑, 2,   EMT↓, 9,   EP4/PTGER4↑, 1,   ERK↓, 2,   ERK↑, 1,   FOXM1↓, 1,   FOXO1↓, 1,   FOXO3↑, 1,   Gli1↓, 4,   GSK‐3β↓, 1,   GSK‐3β↑, 1,   HDAC↓, 2,   HDAC↑, 1,   HDAC2↓, 1,   HH↓, 1,   IGFBP3↓, 1,   LRP6↓, 1,   mTOR↓, 5,   p‑mTOR↓, 1,   mTORC1↓, 1,   Nanog↓, 2,   NOTCH2↑, 1,   OCT4↓, 2,   p‑P70S6K↓, 1,   PDGFRA↓, 1,   PI3K↓, 5,   PTCH1↓, 1,   PTEN↓, 1,   Shh↓, 2,   Smo↓, 3,   SOX2↓, 1,   STAT3↓, 2,   TCF↓, 1,   TumCG↓, 49,   TumCG↑, 1,   Wnt↓, 2,  

Migration(tgid=13) ⓘ

Ca+2↑, 3,   Ca+2↝, 1,   E-cadherin↑, 3,   ER-α36↓, 1,   FAK↓, 1,   GIT1↓, 1,   GLI2↓, 2,   Ki-67↓, 3,   LEF1↓, 1,   MALAT1↓, 1,   MARK4↓, 1,   MMP2↓, 5,   MMP9↓, 5,   N-cadherin↓, 1,   Slug↓, 2,   Snail↓, 4,   talin↓, 1,   TumCI↓, 6,   TumCMig↓, 5,   TumCP↓, 10,   TumMeta↓, 4,   Twist↓, 1,   TXNIP↑, 1,   Vim↓, 2,   Zeb1↓, 3,   β-catenin/ZEB1↓, 3,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 7,   EGFR↓, 2,   Hif1a↓, 3,   VEGF↓, 3,   VEGFR2/KDR/Flk1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   GLUT1↓, 1,   P-gp/ABCB1↓, 3,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

ASC↑, 1,   COX2/PTGS2↓, 2,   ICAM-1↓, 1,   IL1↓, 1,   IL2↓, 1,   IL6↑, 1,   Inflam↓, 1,   NF-kB↓, 6,   p‑NF-kB↓, 1,   p‑p65↓, 1,   PSA↓, 2,   TLR4↓, 1,  

Protein Aggregation(tgid=19) ⓘ

NLRP3↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 3,   COMT↑, 1,   ERβ/ESR2↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↝, 2,   ChemoSen↑, 10,   Dose↝, 8,   eff↓, 5,   eff↑, 12,   RadioS↑, 3,   selectivity↑, 8,  

Clinical Biomarkers(tgid=22) ⓘ

AR↓, 3,   EGFR↓, 2,   FOXM1↓, 1,   HER2/EBBR2↓, 2,   IL6↑, 1,   Ki-67↓, 3,   LDH↓, 1,   Myc↓, 2,   PSA↓, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 4,   AntiTum↑, 6,   chemoP↑, 1,   chemoPv↑, 2,   OS↑, 2,   Risk↓, 2,   toxicity↓, 1,   TumVol↓, 2,  
Total Targets: 246

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 4,   DPPH↓, 1,   GSTs↑, 1,   HO-1↑, 1,   NQO1↑, 1,   NRF2↑, 2,   ROS↓, 5,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

MMP↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT?, 1,   ECAR∅, 1,   LDL↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other?, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

EMT↓, 1,   tyrosinase↓, 1,  

Migration(tgid=13) ⓘ

5LO↓, 1,   Snail↑, 1,   Twist↑, 1,   Vim↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,   HMGB1↓, 1,   IL17↓, 1,   IL1β↓, 2,   IL6↓, 1,   Inflam↓, 7,   NF-kB↓, 1,   PGE2↓, 2,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 1,   Dose↝, 1,   eff↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT?, 1,   AST↓, 1,   IL6↓, 1,  

Functional Outcomes(tgid=23) ⓘ

cardioP↑, 1,   chemoPv↑, 1,   cognitive↑, 1,   hepatoP↑, 2,   memory↑, 2,   neuroP↑, 2,   PDE4↓, 1,   toxicity↓, 5,   toxicity↑, 1,   toxicity∅, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiFungal↑, 1,   Bacteria↓, 1,  
Total Targets: 45

Scientific Paper Hit Count for: TumCG, Tumor cell growth
29 Curcumin
27 Magnetic Fields
17 Phenethyl isothiocyanate
16 Quercetin
14 Berberine
14 EGCG (Epigallocatechin Gallate)
14 Sulforaphane (mainly Broccoli)
13 Silver-NanoParticles
13 Chemotherapy
13 Shikonin
12 Vitamin C (Ascorbic Acid)
12 Magnetic Field Rotating
12 Bicarbonate(Sodium)
11 Alpha-Lipoic-Acid
11 Baicalein
11 Garcinol
11 IP6 (Inositol 1,2,3,4,5,6-hexakisphosphate)
10 Capsaicin
10 Apigenin (mainly Parsley)
10 chaetocin
10 Fisetin
9 Cucurbitacin
9 Silymarin (Milk Thistle) silibinin
9 Resveratrol
9 Dichloroacetate
9 Deguelin
9 Formononetin
8 Astragalus
8 Artemisinin
8 salinomycin
8 diet FMD Fasting Mimicking Diet
8 Emodin
8 Gambogic Acid
8 Ginkgetin
8 Honokiol
8 Phenylbutyrate
8 Pterostilbene
8 Urolithin
7 Radiotherapy/Radiation
7 Allicin (mainly Garlic)
7 HydroxyCitric Acid
7 Ashwagandha(Withaferin A)
7 immunotherapy
7 Boron
7 Boswellia (frankincense)
7 Crocetin
6 Metformin
6 Cisplatin
6 Betulinic acid
6 Chrysin
6 Coenzyme Q10
6 Gemcitabine (Gemzar)
6 diet Methionine-Restricted Diet
6 Sulfasalazine
6 Isoliquiritigenin
6 Magnolol
6 Indole-3-carbinol
6 Inulin Prebiotic
6 Lycopene
6 Magnesium
6 Rosmarinic acid
6 α-Santalol/Sandalwood oil
5 chitosan
5 Melatonin
5 Berbamine
5 Beta-Caryophyllene
5 Centella asiatica / Gotu kola → asiaticoside
5 Citric Acid
5 Dandelion Root
5 Eugenol
5 Gallic acid
5 Graviola
5 isoquercitrin
5 Juglone
4 3-bromopyruvate
4 Fenbendazole
4 Paclitaxel/Taxol
4 Astaxanthin
4 Atorvastatin
4 Dipyridamole
4 Brucea javanica
4 Butyrate
4 Caffeic Acid Phenethyl Ester (CAPE)
4 Cynaropicrin
4 Docosahexaenoic Acid
4 Disulfiram
4 Evodiamine
4 Genistein (soy isoflavone)
4 Hydrogen Gas
4 Hyperoside
4 Isobavachalcone
4 Luteolin
4 Nimbolide
4 Piperine
4 Piperlongumine
4 Selenite (Sodium)
4 Thymoquinone
4 Vitamin K2
4 VitK3,menadione
3 Caffeic acid
3 Diclofenac
3 doxorubicin
3 Baicalin
3 Bufalin/Huachansu
3 brusatol
3 Bruteridin(bergamot juice)
3 Carvacrol
3 Celastrol
3 Chlorogenic acid
3 Selenium NanoParticles
3 Copper and Cu NanoParticles
3 Photodynamic Therapy
3 tamoxifen
3 Ellagic acid
3 eicosapentaenoic acid
3 Fucoidan
3 Geraniol
3 Ginger/6-Shogaol/Gingerol
3 Glabrescione B
3 Gossypol/AT-101
3 HydroxyTyrosol
3 Inositol
3 Niclosamide (Niclocide)
3 Propyl gallate
3 Plumbagin
3 Terpinen-4-ol / Tea Tree Oil
3 Aflavin-3,3′-digallate
2 2-DeoxyGlucose
2 Auranofin
2 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
2 Andrographis
2 Anethole/trans-Anethole
2 Fennel Oil/Foeniculum vulgare
2 Ascorbyl Palmitate
2 Biochanin A
2 Bifidobacterium
2 Bromelain
2 α-Bisabolol / Chamomile oil
2 Carnosic acid
2 Cinnamon
2 Cynara scolymus/Globe Artichoke/Artichoke Extract
2 Polyphenols
2 Cyclopamine
2 Oxygen, Hyperbaric
2 diet Short Term Fasting
2 D-limonene
2 Ginkgo biloba-EGb 761
2 ferumoxytol
2 Galloflavin
2 Ginkgo biloba
2 Ginkgolide B
2 Grapeseed extract
2 Hydroxycinnamic-acid
2 iodine
2 metronomic chemo
2 Isovitexin
2 Linalool
2 Methylene blue
2 Oroxylin-A
2 Oleuropein
2 Orlistat
2 Psoralidin
2 Hyperthermia
2 EMF
2 Oxaliplatin
2 Spermidine
2 Ursolic acid
2 Vitexin
2 Whole Body Vibration
1 1,8-Cineole
1 5-fluorouracil
1 Anzaroot, Astragalus fasciculifolius Bioss
1 octreotide
1 Acetyl-l-carnitine
1 DTS(dibenzyl trisulphide) from Anamu
1 Angelica archangelica / Garden Angelica
1 Anti-oxidants
1 5-Aminolevulinic acid
1 Aloe anthraquinones
1 beta-glucans
1 temozolomide
1 Bacopa monnieri
1 Caffeine
1 urea
1 Cat’s Claw
1 Cannabidiol
1 Celecoxib
1 Chocolate
1 Calorie Restriction Mimetics
1 Carvone
1 Bicalutamide
1 CUSP9
1 Dichloroacetophenone(2,2-)
1 Dasatinib/Phyrago
1 Bortezomib
1 Date Fruit Extract
1 diet Ketogenic
1 diet Plant based
1 Aspirin
1 Zinc
1 Echinacea
1 PXD, phenoxodiol
1 Sorafenib (brand name Nexavar)
1 Electrical Pulses
1 erastin
1 Eurycomanone
1 Shilajit/Fulvic Acid
1 Ginkgolic acids
1 Hibiscus sabdariffa
1 itraconazole
1 Ivermectin
1 Laetrile B17 Amygdalin
1 Licorice
1 mebendazole
1 Methylglyoxal
1 Mushroom Chaga
1 Naringin
1 Noscapine
1 Parthenolide
1 raloxifen
1 Salvia officinalis
1 Vorinostat
1 Selenium
1 irinotecan
1 Salvia miltiorrhiza
1 Saikosaponin B1 and D
1 Sutherlandioside D
1 cetuximab
1 Taurine
1 Tomatine
1 triptolide
1 Tumor Treating Fields
1 Turmerones
1 Vitamin B1/Thiamine
1 Vitamin B5,Pantothenic Acid
1 Transarterial Chemoembolization
1 γ-Tocotrienol
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:323  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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