ROS Cancer Research Results

ROS, Reactive Oxygen Species: Click to Expand ⟱
Source: HalifaxProj (inhibit)
Type:
Reactive oxygen species (ROS) are highly reactive molecules that contain oxygen and can lead to oxidative stress in cells. They play a dual role in cancer biology, acting as both promoters and suppressors of cancer.
ROS can cause oxidative damage to DNA, leading to mutations that may contribute to cancer initiation and progression. So normally you want to inhibit ROS to prevent cell mutations.
However excessive ROS can induce apoptosis (programmed cell death) in cancer cells, potentially limiting tumor growth. Chemotherapy typically raises ROS.
-mitochondria is the main source of reactive oxygen species (ROS) (and the ETC is heavily related)
ROS Homeostasis in Cancer Cells and Its Potential as a Therapeutic Target

"Reactive oxygen species (ROS) are two electron reduction products of oxygen, including superoxide anion, hydrogen peroxide, hydroxyl radical, lipid peroxides, protein peroxides and peroxides formed in nucleic acids 1. They are maintained in a dynamic balance by a series of reduction-oxidation (redox) reactions in biological systems and act as signaling molecules to drive cellular regulatory pathways."
"During different stages of cancer formation, abnormal ROS levels play paradoxical roles in cell growth and death 8. A physiological concentration of ROS that maintained in equilibrium is necessary for normal cell survival. Ectopic ROS accumulation promotes cell proliferation and consequently induces malignant transformation of normal cells by initiating pathological conversion of physiological signaling networks. Excessive ROS levels lead to cell death by damaging cellular components, including proteins, lipid bilayers, and chromosomes. Therefore, both scavenging abnormally elevated ROS to prevent early neoplasia and facilitating ROS production to specifically kill cancer cells are promising anticancer therapeutic strategies, in spite of their contradictoriness and complexity."
"ROS are the collection of derivatives of molecular oxygen that occur in biology, which can be categorized into two types, free radicals and non-radical species. The non-radical species are hydrogen peroxide (H 2O 2 ), organic hydroperoxides (ROOH), singlet molecular oxygen ( 1 O 2 ), electronically excited carbonyl, ozone (O3 ), hypochlorous acid (HOCl, and hypobromous acid HOBr). Free radical species are super-oxide anion radical (O 2•−), hydroxyl radical (•OH), peroxyl radical (ROO•) and alkoxyl radical (RO•) [130]. Any imbalance of ROS can lead to adverse effects. H2 O 2 and O 2 •− are the main redox signalling agents. The cellular concentration of H2 O 2 is about 10−8 M, which is almost a thousand times more than that of O2 •−".
"Radicals are molecules with an odd number of electrons in the outer shell [393,394]. A pair of radicals can be formed by breaking a chemical bond or electron transfer between two molecules."

Recent investigations have documented that polyphenols with good antioxidant activity may exhibit pro-oxidant activity in the presence of copper ions, which can induce apoptosis in various cancer cell lines but not in normal cells. "We have shown that such cell growth inhibition by polyphenols in cancer cells is reversed by copper-specific sequestering agent neocuproine to a significant extent whereas iron and zinc chelators are relatively ineffective, thus confirming the role of endogenous copper in the cytotoxic action of polyphenols against cancer cells. Therefore, this mechanism of mobilization of endogenous copper." > Ions could be one of the important mechanisms for the cytotoxic action of plant polyphenols against cancer cells and is possibly a common mechanism for all plant polyphenols. In fact, similar results obtained with four different polyphenolic compounds in this study, namely apigenin, luteolin, EGCG, and resveratrol, strengthen this idea.
Interestingly, the normal breast epithelial MCF10A cells have earlier been shown to possess no detectable copper as opposed to breast cancer cells [24], which may explain their resistance to polyphenols apigenin- and luteolin-induced growth inhibition as observed here (Fig. 1). We have earlier proposed [25] that this preferential cytotoxicity of plant polyphenols toward cancer cells is explained by the observation made several years earlier, which showed that copper levels in cancer cells are significantly elevated in various malignancies. Thus, because of higher intracellular copper levels in cancer cells, it may be predicted that the cytotoxic concentrations of polyphenols required would be lower in these cells as compared to normal cells."

Majority of ROS are produced as a by-product of oxidative phosphorylation, high levels of ROS are detected in almost all cancers.
-It is well established that during ER stress, cytosolic calcium released from the ER is taken up by the mitochondrion to stimulate ROS overgeneration and the release of cytochrome c, both of which lead to apoptosis.

Note: Products that may raise ROS can be found using this database, by:
Filtering on the target of ROS, and selecting the Effect Direction of ↑

Targets to raise ROS (to kill cancer cells):
• NADPH oxidases (NOX): NOX enzymes are involved in the production of ROS.
    -Targeting NOX enzymes can increase ROS levels and induce cancer cell death.
    -eNOX2 inhibition leads to a high NADH/NAD⁺ ratio which can lead to increased ROS
• Mitochondrial complex I: Inhibiting can increase ROS production
• P53: Activating p53 can increase ROS levels(by inducing the expression of pro-oxidant genes)
• Nrf2 inhibition: regulates the expression of antioxidant genes. Inhibiting Nrf2 can increase ROS levels
• Glutathione (GSH): an antioxidant. Depleting GSH can increase ROS levels
• Catalase: Catalase converts H2O2 into H2O+O. Inhibiting catalase can increase ROS levels
• SOD1: converts superoxide into hydrogen peroxide. Inhibiting SOD1 can increase ROS levels
• PI3K/AKT pathway: regulates cell survival and metabolism. Inhibiting can increase ROS levels
• HIF-1α inhibition: regulates genes involved in metabolism and angiogenesis. Inhibiting HIF-1α can increase ROS
• Glycolysis: Inhibiting glycolysis can increase ROS levels • Fatty acid oxidation: Cancer cells often rely on fatty acid oxidation for energy production.
-Inhibiting fatty acid oxidation can increase ROS levels
• ER stress: Endoplasmic reticulum (ER) stress can increase ROS levels
• Autophagy: process by which cells recycle damaged organelles and proteins.
-Inhibiting autophagy can increase ROS levels and induce cancer cell death.
• KEAP1/Nrf2 pathway: regulates the expression of antioxidant genes.
    -Inhibiting KEAP1 or activating Nrf2 can increase ROS levels and induce cancer cell death.
• DJ-1: regulates the expression of antioxidant genes. Inhibiting DJ-1 can increase ROS levels
• PARK2: regulates the expression of antioxidant genes. Inhibiting PARK2 can increase ROS levels
• SIRT1 inhibition:regulates the expression of antioxidant genes. Inhibiting SIRT1 can increase ROS levels
• AMPK activation: regulates energy metabolism and can increase ROS levels when activated.
• mTOR inhibition: regulates cell growth and metabolism. Inhibiting mTOR can increase ROS levels
• HSP90 inhibition: regulates protein folding and can increase ROS levels when inhibited.
• Proteasome: degrades damaged proteins. Inhibiting the proteasome can increase ROS levels
• Lipid peroxidation: a process by which lipids are oxidized, leading to the production of ROS.
    -Increasing lipid peroxidation can increase ROS levels
• Ferroptosis: form of cell death that is regulated by iron and lipid peroxidation.
    -Increasing ferroptosis can increase ROS levels
• Mitochondrial permeability transition pore (mPTP): regulates mitochondrial permeability.
    -Opening the mPTP can increase ROS levels
• BCL-2 family proteins: regulate apoptosis and can increase ROS levels when inhibited.
• Caspase-independent cell death: a form of cell death that is regulated by ROS.
    -Increasing caspase-independent cell death can increase ROS levels
• DNA damage response: regulates the repair of DNA damage. Increasing DNA damage can increase ROS
• Epigenetic regulation: process by which gene expression is regulated.
    -Increasing epigenetic regulation can increase ROS levels

-PKM2, but not PKM1, can be inhibited by direct oxidation of cysteine 358 as an adaptive response to increased intracellular reactive oxygen species (ROS)

ProOxidant Strategy:(inhibit the Mevalonate Pathway (likely will also inhibit GPx)
-HydroxyCitrate (HCA) found as supplement online and typically used in a dose of about 1.5g/day or more
-Atorvastatin typically 40-80mg/day, -Dipyridamole typically 200mg 2x/day Combined effect research
-Lycopene typically 100mg/day range (note debatable as it mainly lowers NRF2)

Dual Role of Reactive Oxygen Species and their Application in Cancer Therapy 
ROS-Inducing Interventions in Cancer — Canonical + Mechanistic Reference
-generated from AI and Cancer database
ROS rating:  +++ strong | ++ moderate | + weak | ± mixed | 0 none
NRF2:        ↓ suppressed | ↑ activated | ± mixed | 0 none
Conditions:  [D] dose  [Fe] metal  [M] metabolic  [O₂] oxygen
             [L] light [F] formulation [T] tumor-type [C] combination




Item ROS↑ NRF2 Condition Mechanism Class Remarks 



ROS">Piperlongumine
+++ ↓ [D][T] ROS-dominant






ROS">Shikonin
+++↓/±[D][T]ROS-dominant






ROS">Vitamin K3 (menadione)
+++↓[D]ROS-dominant






ROS">Copper (ionic / nano)
+++↓[Fe][F]ROS-dominant






ROS">Sodium Selenite
+++↓[D]ROS-dominant






ROS">Juglone
+++↓[D]ROS-dominant






ROS">Auranofin
+++↓[D]ROS-dominant






ROS">Photodynamic Therapy (PDT)
+++0[L][O₂]ROS-dominant






ROS">Radiotherapy / Radiation
+++0[O₂]ROS-dominant






ROS">Doxorubicin
+++↓[D]ROS-dominant






ROS">Cisplatin
++↓[D][T]ROS-dominant






ROS">Salinomycin
++↓[D][T]ROS-dominant






ROS">Artemisinin / DHA
++↓[Fe][T]ROS-dominant






ROS">Sulfasalazine
++↓[C][T]ROS-dominant






ROS">FMD / fasting
++↓[M][C][O₂]ROS-dominant






ROS">Vitamin C (pharmacologic)
++↓[Fe][D]ROS-dominant






ROS">Silver nanoparticles
++±[F][D]ROS-dominant






ROS">Gambogic acid
++↓[D][T]ROS-dominant






ROS">Parthenolide
++↓[D][T]ROS-dominant






ROS">Plumbagin
++↓[D]ROS-dominant






ROS">Allicin
++↓[D]ROS-dominant






ROS">Ashwagandha (Withaferin A)
++↓[D][T]ROS-dominant






ROS">Berberine
++↓[D][M]ROS-dominant






ROS">PEITC
++↓[D][C]ROS-dominant






ROS">Methionine restriction
+↓[M][C][T]ROS-secondary






ROS">DCA
+±[M][T]ROS-secondary






ROS">Capsaicin
+±[D][T]ROS-secondary






ROS">Galloflavin
+0[D]ROS-secondary






ROS">Piperine
+±[D][F]ROS-secondary






ROS">Propyl gallate
+↓[D]ROS-secondary






ROS">Scoulerine
+?[D][T]ROS-secondary






ROS">Thymoquinone
±±[D][T]Dual redox






ROS">Emodin
±±[D][T]Dual redox






ROS">Alpha-lipoic acid (ALA)
±↑[D][M]NRF2-dominant






ROS">Curcumin
±↑/↓[D][F]NRF2-dominant






ROS">EGCG
±↑/↓[D][O₂]NRF2-dominant






ROS">Quercetin
±↑/↓[D][Fe]NRF2-dominant






ROS">Resveratrol
±↑[D][M]NRF2-dominant






ROS">Sulforaphane
±↑↑[D]NRF2-dominant






ROS">Lycopene
0↑—Antioxidant






ROS">Rosmarinic acid
0↑—Antioxidant






ROS">Citrate
00—Neutral


Scientific Papers found: Click to Expand⟱
7167- CHA,    Chaetocin-induced ROS-mediated apoptosis involves ATM-YAP1 axis and JNK-dependent inhibition of glucose metabolism
- vitro+vivo, GBM, A172 - in-vitro, GBM, T98G - in-vitro, GBM, U87MG
HMTs↓, ROS↑, YAP/TEAD↑, ATM↑, JNK↑, Apoptosis↑, GlucoseCon↓, lactateProd↓, ATP↓, TumCP↓, TrxR↓, Trx1↓, H3K9↓, p‑ATM↑, γH2AX↑, ALDOB↑, ENO3↑, FBP1↑, GSK‐3β↑, HK3↑, PCK1↑, PGK2↑, PGM1↑, PGM3↑, PHKG1↑, PKLR↑, HK2↓, PCNA↓,
7166- CHA,    Anti-leukemia activity of chaetocin via death receptor-dependent apoptosis and dual modulation of the histone methyl-transferase SUV39H1
- vitro+vivo, AML, U937
SUV39H↓, Apoptosis↑, ROS↑, TumCCA↑, tumCV↓, Casp3↑, Casp9↑, Fas↑, FasL↑, DR4↑, P21↑, eff↓, eff↑,
7165- CHA,    The anticancer agent chaetocin is a competitive substrate and inhibitor of thioredoxin reductase
- in-vitro, Cerv, HeLa
ROS↑, TumCD↑, TrxR1↓, other↝, GSR↓, Trx↓, eff↓,
7164- CHA,    Chaetocin induces apoptosis in human melanoma cells through the generation of reactive oxygen species and the intrinsic mitochondrial pathway, and exerts its anti-tumor activity in vivo
- vitro+vivo, Melanoma, A375
TumCP↓, Apoptosis↑, ROS↑, eff↓, MMP↓, Cyt‑c↑, BAX↑, cl‑Casp3↑, cl‑Casp9↑, Bcl-2↓, TumCG↓, PCNA↓, tumCV↓, NRF2↑, SOD2↑, Catalase↑, NRF2↓, SOD2↓, Catalase↓, TrxR↓,
7163- CHA,    The anticancer effects of chaetocin are independent of programmed cell death and hypoxia, and are associated with inhibition of endothelial cell proliferation
- in-vitro, Lung, A549 - in-vitro, OS, U2OS - in-vitro, CRC, HCT116 - in-vitro, CRC, HeLa - in-vivo, Ovarian, SKOV3
ROS↑, Trx↓, Apoptosis↑, TumCG↓, SUV39H↓, Hif1a↓, TumCP↓, eff↓, MMP↓, TumCG↓, Dose↝, toxicity↓,
7160- CHA,    Chaetocin: a promising new antimyeloma agent with in vitro and in vivo activity mediated via imposition of oxidative stress
- in-vitro, Lung, A549
selectivity↑, eff↑, ROS↑, Apoptosis↓, HDAC↓, MMP↓, cl‑PARP↑, eff↑, eff↓, i-GSH∅,
7159- CHA,    ROS-mediated inactivation of the PI3K/AKT pathway is involved in the antigastric cancer effects of thioredoxin reductase-1 inhibitor chaetocin
- vitro+vivo, GC, HGC27 - in-vitro, GC, AGS - in-vitro, GC, BGC-823 - in-vitro, GC, SGC-7901 - in-vitro, Nor, HEK293
TumCP↓, TumCCA↑, Casp↑, Apoptosis↑, TrxR1↓, ROS↑, eff↓, eff↑, PI3K↓, Akt↓, TumCG↓, cl‑PARP↑, cl‑Casp3↑, cl‑Casp9↑, cl‑Casp8↑, Bcl-2↓, Bcl-xL↓, Mcl-1↓, XIAP↓, survivin↓, TumVol↓, TumW↓, Weight∅, toxicity↓, Ki-67↓, other↝,
6001- Chit,    Recent advances in engineering chitosan-based nanoplatforms in biotherapeutic multi-delivery for multi-targeted disease treatments: Promises and outlooks
- Review, Var, HepG2 - Review, AD, NA
TumVol↓, toxicity↓, Half-Life↑, eff↑, selectivity↑, Dose↝, *BDNF↑, *NRF2↑, *ROS↓, *neuroP↑, *memory↑, *cognitive↑, *Obesity↓,
5988- Chit,    Chitosan immunomodulation: insights into mechanisms of action on immune cells and signaling pathways
- Review, Var, NA
DDS↑, *Cartilage↑, *Wound Healing↑, Imm↑, cGAS–STING↑, STAT1↑, NLRP3↑, *DCells↑, *IL10↓, *TGF-β1↓, *TNF-α↓, IL1β↓, ROS↑,
5991- Chit,    Chitosan-Based Nanoencapsulated Essential Oils: Potential Leads against Breast Cancer Cells in Preclinical Studies
- Review, BC, NA
*other↝, *BioAv↓, eff↑, toxicity↓, eff↑, TumCD↑, Half-Life↑, selectivity↑, EPR↑, ROS↑, Apoptosis↑, eff↑,
5995- Chit,  CUR,    Enhancement of anticancer activity and drug delivery of chitosan-curcumin nanoparticle via molecular docking and simulation analysis
- vitro+vivo, Var, NA
eff↑, EPR↑, DNAdam↑, TumCCA↑, ROS↑, toxicity↓,
5994- Chit,    Anticancer Activity of Chitosan, Chitosan Derivatives, and Their Mechanism of Action
- Review, Var, NA
angioG↓, *Imm↑, *antiOx↑, selectivity↑, other↝, toxicity↓, BioAv↑, eff↝, Half-Life↑, MPT↑, MMP9↓, lipid-P↑, EPR↑, NK cell↑, Casp3↑, Casp8↑, TumCCA↑, ROS↑, DDS↑, VEGF↓, TIMP1↑, ChemoSen↑, eff↑,
5990- Chit,    Chitosan Nanoparticles for Targeted Cancer Therapy: A Review of Stimuli-Responsive, Passive, and Active Targeting Strategies
- Review, Var, NA
DDS↑, eff↓, *Bacteria↓, *antiOx↑, *Wound Healing↑, *Imm↑, TumCP↓, TumMeta↓, angioG↓, Apoptosis↑, ROS↑, ER Stress↑, BioAv↑, Half-Life↑, eff↑, EPR↑, ChemoSen↑, eff↑,
4478- Chit,    Chitosan promotes ROS-mediated apoptosis and S phase cell cycle arrest in triple-negative breast cancer cells: evidence for intercalative interaction with genomic DNA
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF7 - in-vitro, BC, T47D
TumCP↓, selectivity↑, MMP↓, ROS↑, TumCCA↑, Apoptosis↑, Casp3↑,
4479- Chit,    Chitosan nanoparticles triggered the induction of ROS-mediated cytoprotective autophagy in cancer cells
- in-vitro, Cerv, HeLa - in-vitro, HCC, SMMC-7721 cell
TumAuto↑, ROS↑, eff↓,
4481- Chit,    Antioxidant Properties and Redox-Modulating Activity of Chitosan and Its Derivatives: Biomaterials with Application in Cancer Therapy
- Review, Var, NA
*BioAv↑, *toxicity↓, *antiOx↑, AntiCan↑, *Inflam↓, *ROS↓, *lipid-P↓, MDA↓, selectivity↑, MMP↓, ROS↑, TumCCA↑, MDA↑, GSH↓, ChemoSen↑,
4482- Chit,    Hyaluronic acid-coated chitosan nanoparticles induce ROS-mediated tumor cell apoptosis and enhance antitumor efficiency by targeted drug delivery via CD44
- in-vitro, Lung, A549 - in-vitro, Liver, HepG2
EPR↑, mtDam↑, ROS↑, Apoptosis↑,
6080- CHL,  VitC,    Protective Effects of Sodium Copper Chlorophyllin and/or Ascorbic Acid Against Barium Chloride-Induced Oxidative Stress in Mouse Brain and Liver
- in-vivo, Nor, NA
*neuroP↑, *MDA↓, *hepatoP↑, *IronCh↑, *ROS↓, *lipid-P↓,
6078- CHL,    Update on the bioavailability and chemopreventative mechanisms of dietary chlorophyll derivatives
- Review, Nor, NA
*BioAv↑, chemoPv↑, *ROS↓, eff↑,
6070- CHL,    Preclinical evaluation of sodium copper chlorophyllin: safety, pharmacokinetics, and therapeutic potential in breast cancer chemotherapy and cyclophosphamide-induced bladder toxicity
- in-vitro, BC, 4T1
TumCP↓, DNAdam↑, Apoptosis↑, *ROS↓, *toxicity↓, ChemoSen↑,
6073- CHL,  GEM,    Chlorophyllin exerts synergistic anti-tumor effect with gemcitabine in pancreatic cancer by inducing cuproptosis
- in-vitro, PC, NA
ChemoSen↑, eff↑, AntiTum↑, TumCP↓, TumCI↓, TumCMig↓, Apoptosis↑, GSH↓, ROS↑, HSP70/HSPA5↑,
6075- CHL,  docx,    The effect of the combination therapy with chlorophyllin, a glutathione transferase P1-1 inhibitor, and docetaxel on triple-negative breast cancer invasion and metastasis in vivo/in vitro
- vitro+vivo, BC, 4T1
TumCMig↓, eff↑, TumMeta↓, TumCCA↑, Trx↓, ROS↓, TumCD↑, GSTP1/GSTπ↓,
6069- CHL,  PDT,    Anti-Cancer Effect of Chlorophyllin-Assisted Photodynamic Therapy to Induce Apoptosis through Oxidative Stress on Human Cervical Cancer
- in-vitro, Cerv, HeLa
eff↑, ROS↑, Casp8↓, Casp9↑, BAX↑, Cyt‑c↑, Bcl-2↓, AKT1↓,
6082- CHOC,    Potential for preventive effects of cocoa and cocoa polyphenols in cancer
- Review, Var, NA
*ROS↓, Apoptosis↑, Inflam↓, TumCP↓, angioG↓, TumMeta↓, *Ca+2↓, *MMP∅, CYP1A1↑, PGE2↓, TumCCA↑, chemoPv↑,
6083- CHOC,    Preventive Effects of Cocoa and Cocoa Antioxidants in Colon Cancer
- Review, Colon, NA
ROS↓, Inflam↓, TumCP↓, Apoptosis↑, *Dose↝, *BioAv↓, *BioAv↑, GSH↑, GSTs↑, PGE2↓, COX1↑, IL8↓, COX2/PTGS2↓, iNOS↓, NF-kB↓, chemoP↑,
6084- CHOC,    Cocoa Polyphenols and Their Potential Benefits for Human Health
- Review, Nor, NA - Review, Stroke, NA - Review, IBD, NA
*lipid-P↓, *ROS↓, *Inflam↓, *BP↓, *cardioP↑, *chemoPv↑, *BioAv⇅, *antiOx↑, *Risk↓, *5LO↓, *AntiAg↑, *Imm↑, *NF-kB↓, *other↓, CYP1A1↓, COX2/PTGS2↓, *Obesity↓, *cognitive↑,
6086- CHOC,    Cocoa and Chocolate in Human Health and Disease
- Review, Var, NA
*antiOx↑, *AntiDiabetic↑, *cognitive↑, *AntiAg↑, *AntiAg↑, *LDL↓, *HDL↑, *BP↓, *eff↓, *ROS↓,
6088- CHOC,    Effect of chocolate on older patients with cancer in palliative care: a randomised controlled study
- Trial, Var, NA
eff↑, *ROS↓, *MDA↓, *GSH↑,
6107- Chol,    Choline supplements: An update
- Review, AD, NA
*memory↑, *cognitive↑, *Dose↝, *BBB↑, *cardioP↑, *ROS↓, *TMAO↑, *memory∅, *eff↑,
6108- Chol,    Trimethylamine-N-Oxide (TMAO) as a Rising-Star Metabolite: Implications for Human Health
- Review, Nor, NA - Review, AD, NA
*TMAO↑, *ROS↑, *NADPH↑, *Ca+2↑, *AntiAg↓, *cognitive↓, *TJ↓, *CLDN1↓, *ZO-1↓, *Inflam↑, *NLRP3↑, *ER Stress↑, *cognitive↓, *Dose↝, *eff↑, *other↝, *other↝, *other↝,
3700- Chol,    Eggs and Health Special Issue
- Review, Nor, NA
*other↑, *other↑, *Inflam↓, *ROS↓, *antiOx↑, *Iron↑, *cardioP∅,
6131- CHr,  Bor,  Z,    Fabrication of phenyl boronic acid modified pH-responsive zinc oxide nanoparticles as targeted delivery of chrysin on human A549 cells
- in-vitro, Lung, A549
*BioAv↑, ROS↑, TumCD↑, TumCCA↑, MMP2↓, TumMeta↓, TumCI↓, GSH↓, eff↑,
6139- CHr,    Chrysin and its nanoformulations in cancer therapy: A systematic review of their radiosensitizing, phototherapy-enhancing potentials
- Review, Var, NA
RadioS↑, PhotoS↑, ROS↑, DNAdam↑, TumCCA↑, TumCD↑, selectivity↑, *ROS↓, *Inflam↓, *DNAdam↓, *antiOx↑, *lipid-P↓, *BioAv↑, eff↑, GSH↓, Catalase↓, ALAT↓, Ca+2↓, MDA↑,
6135- CHr,    Chrysin as a Multifunctional Therapeutic Flavonoid: Emerging Insights in Pathogenesis Management: A Narrative Review
- Review, Var, NA - Review, AD, NA
Inflam↓, angioG↓, Apoptosis↑, TumAuto↑, TumCCA↑, BioAv↓, Half-Life↓, BioAv↓, *ROS↓, *hepatoP↑, *RenoP↑, TET1↑, MMP9↓, cMyc↓, Ki-67↓, CBR1↓, ROS↑, ChemoSen↑, Bax:Bcl2↑, PUMA↑, NOTCH1↑, *AntiDiabetic↑, *neuroP↑, *GABA↑, *DNAdam↓, *BDNF↑, *memory↑, *AGEs↓, *Aβ↓, *cardioP↑, *AntiArt↑, eff↑, eff↑, *eff↑, RadioS↑, eff↑, ChemoSen↑, eff↑,
6138- CHr,  Cisplatin,    Chrysin protects against cisplatin-induced colon. toxicity via amelioration of oxidative stress and apoptosis: Probable role of p38MAPK and p53
- in-vivo, Nor, NA
*toxicity↝, eff↑, chemoP↑, *ROS↓, *MAPK↑, *P53↑, GSH↓,
6128- CHr,    Chrysin: A Comprehensive Review of Its Pharmacological Properties and Therapeutic Potential
- Review, Nor, NA - Review, Var, NA - Review, AD, NA
*antiOx↑, *Inflam↓, AntiCan↑, *neuroP↑, *ROS↓, *BioAv↓, *BioAv↑, *cardioP↑, *COX2/PTGS2↓, *TNF-α↓, *IL1β↓, *NF-kB↓, *lipid-P↓, *Apoptosis↓, *NRF2↑, *HO-1↑, *MDA↓, *GSH↑, *SOD↑, *GPx↑, *GSR↑, *Catalase↑, *5HT↑, *Casp3↓, *Casp9↓, TumCCA↑, MAPK↓, PI3K↓, Akt↓, TumCP↓, TET1↑, TLR4↓, HER2/EBBR2↓, HK2↓, Glycolysis↓, glucose↓, lactateProd↓, ROS↑, mTOR↓, TumAuto↑, tumCV↓, ER Stress↑, UPR↑, PERK↑, ATF4↑, eIF2α↑, BioAv↑,
2796- CHr,    Chemopreventive effect of chrysin, a dietary flavone against benzo(a)pyrene induced lung carcinogenesis in Swiss albino mice
- in-vivo, Lung, NA
PCNA↓, COX2/PTGS2↓, NF-kB↓, chemoPv↑, *SOD↑, *Catalase↓, *GR↓, *GPx↓, *lipid-P↓, *COX2/PTGS2↓, *NF-kB↓, *ROS↓,
2799- CHr,    Chrysin suppresses renal carcinogenesis via amelioration of hyperproliferation, oxidative stress and inflammation: plausible role of NF-κB
- in-vivo, RCC, NA
*chemoPv↑, *ROS↓, *Inflam↓,
2801- CHr,    AMP-activated protein kinase (AMPK) activation is involved in chrysin-induced growth inhibition and apoptosis in cultured A549 lung cancer cells
- in-vitro, Lung, A549
AMPK↑, Akt↓, ChemoSen↑, ROS↑,
2804- CHr,  Rad,    Gamma-Irradiated Chrysin Improves Anticancer Activity in HT-29 Colon Cancer Cells Through Mitochondria-Related Pathway
- in-vitro, CRC, HT29
RadioS↑, ROS↑, MMP↓, Casp3↑, Casp9↑, cl‑PARP↑,
2806- CHr,  Se,    Selenium-containing chrysin and quercetin derivatives: attractive scaffolds for cancer therapy
- in-vitro, Var, NA
eff↑, selectivity↑, Dose↝, TrxR↓, GSH↓, MMP↓, ROS↑, H2O2↑,
2781- CHr,  PBG,    Chrysin a promising anticancer agent: recent perspectives
- Review, Var, NA
PI3K↓, Akt↓, mTOR↓, MMP9↑, uPA↓, VEGF↓, AR↓, Casp↑, TumMeta↓, TumCCA↑, angioG↓, BioAv↓, *hepatoP↑, *neuroP↑, *SOD↑, *GPx↑, *ROS↓, *Inflam↓, *Catalase↑, *MDA↓, ROS↓, BBB↑, Half-Life↓, BioAv↑, ROS↑, eff↑, ROS↑, ROS↑, lipid-P↑, ER Stress↑, NOTCH1↑, NRF2↓, p‑FAK↓, Rho↓, PCNA↓, COX2/PTGS2↓, NF-kB↓, PDK1↓, PDK3↑, GLUT1↓, Glycolysis↓, mt-ATP↓, Ki-67↓, cMyc↓, ROCK1↓, TOP1↓, TNF-α↓, IL1β↓, CycB/CCNB1↓, CDK2↓, EMT↓, STAT3↓, PD-L1↓, IL2↑,
2782- CHr,    Broad-Spectrum Preclinical Antitumor Activity of Chrysin: Current Trends and Future Perspectives
- Review, Var, NA - Review, Stroke, NA - Review, Park, NA
*antiOx↑, *Inflam↓, *hepatoP↑, *neuroP↑, *BioAv↓, *cardioP↑, *lipidLev↓, *RenoP↑, *TNF-α↓, *IL2↓, *PI3K↓, *Akt↓, *ROS↓, *cognitive↑, eff↑, cycD1/CCND1↓, hTERT/TERT↓, VEGF↓, p‑STAT3↓, TumMeta↓, TumCP↓, eff↑, eff↑, IL1β↓, IL6↓, NF-kB↓, ROS↑, MMP↓, Cyt‑c↑, Apoptosis↑, ER Stress↑, Ca+2↑, TET1↑, Let-7↑, Twist↓, EMT↓, TumCCA↑, Casp3↑, Casp9↑, BAX↑, HK2↓, GlucoseCon↓, lactateProd↓, Glycolysis↓, SHP1↑, N-cadherin↓, E-cadherin↑, UPR↑, PERK↑, ATF4↑, eIF2α↑, RadioS↑, NOTCH1↑, NRF2↓, BioAv↑, eff↑,
2784- CHr,    Chrysin targets aberrant molecular signatures and pathways in carcinogenesis (Review)
- Review, Var, NA
Apoptosis↑, TumCMig↓, *toxicity↝, ChemoSen↑, *BioAv↓, Dose↝, neuroP↑, *P450↓, *ROS↓, *HDL↑, *GSTs↑, *SOD↑, *Catalase↑, *MAPK↓, *NF-kB↓, *PTEN↑, *VEGF↑, ROS↑, MMP↓, Ca+2↑, selectivity↑, PCNA↓, Twist↓, EMT↓, CDKN1C/p57↑, p‑STAT3↑, MMP2↓, MMP9↓, eff↑, cycD1/CCND1↓, hTERT/TERT↓, CLDN1↓, TumVol↓, OS↑, COX2/PTGS2↓, eff↑, CDK2↓, CDK4↓, selectivity↑, TumCCA↑, E-cadherin↑, HK2↓, HDAC↓,
2785- CHr,    Emerging cellular and molecular mechanisms underlying anticancer indications of chrysin
- Review, Var, NA
*NF-kB↓, *COX2/PTGS2↓, *iNOS↓, angioG↓, TOP1↓, HDAC↓, TNF-α↓, IL1β↓, cardioP↑, RenoP↑, neuroP↑, LDL↓, BioAv↑, eff↑, cycD1/CCND1↓, hTERT/TERT↓, MMP-10↓, Akt↓, STAT3↓, VEGF↓, EGFR↓, Snail↓, Slug↓, Vim↓, E-cadherin↑, eff↑, TET1↑, ROS↑, mTOR↓, PPARα↓, ER Stress↑, Ca+2↑, ERK↓, MMP↑, Cyt‑c↑, Casp3↑, HK2↓, NRF2↓, HO-1↓, MMP2↓, MMP9↓, Fibronectin↓, GRP78/BiP↑, XBP-1↓, p‑eIF2α↑, *AST↓, ALAT↓, ALP↓, LDH↓, COX2/PTGS2↑, Bcl-xL↓, IL6↓, PGE2↓, iNOS↓, DNAdam↑, UPR↑, Hif1a↓, EMT↓, Twist↓, lipid-P↑, CLDN1↓, PDK1↓, IL10↓, TLR4↓, NOTCH1↑, PARP↑, Mcl-1↓, XIAP↓,
2786- CHr,    Chemopreventive and therapeutic potential of chrysin in cancer: mechanistic perspectives
- Review, Var, NA
Apoptosis↑, TumCCA↑, angioG↓, TumCI↓, TumMeta↑, *toxicity↓, selectivity↑, chemoPv↑, *GSTs↑, *NADPH↑, *GSH↑, HDAC8↓, Hif1a↓, *ROS↓, *NF-kB↓, SCF↓, cl‑PARP↑, survivin↓, XIAP↓, Casp3↑, Casp9↑, GSH↓, ChemoSen↑, Fenton↑, P21↑, P53↑, cycD1/CCND1↓, CDK2↓, STAT3↓, VEGF↓, Akt↓, NRF2↓,
2788- CHr,    Chrysin: Sources, beneficial pharmacological activities, and molecular mechanism of action
- Review, Var, NA
*neuroP↑, *Inflam↓, *ROS↓, NF-kB↓, *PCNA↓, *COX2/PTGS2↓, ChemoSen↑, Hif1a↓, angioG↓, *chemoPv↑, PDGF↓, *memory↑, *RenoP↑, *PPARα↑, *lipidLev↓, *hepatoP↑, *cardioP⇅, *BioAv↓,
2790- CHr,    Chrysin: Pharmacological and therapeutic properties
- Review, Var, NA
*hepatoP↑, *neuroP↓, *ROS↓, *cardioP↑, *Inflam↓, eff↑, hTERT/TERT↓, cycD1/CCND1↓, MMP9↓, MMP2↓, TIMP1↑, TIMP2↑, BioAv↑, HK2↓, ROS↑, MMP↓, Casp3↑, ADP:ATP↑, Apoptosis↑, ER Stress↑, UPR↑, GRP78/BiP↝, eff↑, Ca+2↑,
2791- CHr,    Chrysin attenuates progression of ovarian cancer cells by regulating signaling cascades and mitochondrial dysfunction
- in-vitro, Ovarian, OV90
TumCP↓, TumCD↑, ROS↑, Ca+2↑, MMP↓, MAPK↑, PI3K↑, p‑Akt↑, PCNA↓, p‑p70S6↑, p‑ERK↑, p38↑, JNK↑, DNAdam↑, TumCCA↑, chemoP↑,
2792- CHr,    Chrysin induces death of prostate cancer cells by inducing ROS and ER stress
- in-vitro, Pca, DU145 - in-vitro, Pca, PC3
DNAdam↑, TumCCA↑, MMP↓, ROS↑, lipid-P↑, ER Stress↑, UPR↑, PERK↑, eIF2α↑, GRP78/BiP↑, PI3K↓, Akt↓, p70S6↓, MAPK↑,

Showing Research Papers: 751 to 800 of 2687
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2687

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

ALDOB↑, 1,   CBR1↓, 1,   ENO3↑, 1,   H3K9↓, 1,   HK3↑, 1,   PGK2↑, 1,   PGM3↑, 1,   PHKG1↑, 1,   PKLR↑, 1,   SUV39H↓, 2,  

Redox & Oxidative Stress(tgid=1) ⓘ

Catalase↓, 2,   Catalase↑, 1,   CYP1A1↓, 1,   CYP1A1↑, 1,   Fenton↑, 1,   GSH↓, 7,   GSH↑, 1,   i-GSH∅, 1,   GSR↓, 1,   GSTP1/GSTπ↓, 1,   GSTs↑, 1,   H2O2↑, 1,   HO-1↓, 1,   lipid-P↑, 4,   MDA↓, 1,   MDA↑, 2,   NRF2↓, 5,   NRF2↑, 1,   ROS↓, 3,   ROS↑, 34,   SOD2↓, 1,   SOD2↑, 1,   Trx↓, 3,   Trx1↓, 1,   TrxR↓, 3,   TrxR1↓, 2,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↑, 1,   ATP↓, 1,   mt-ATP↓, 1,   MMP↓, 12,   MMP↑, 1,   MPT↑, 1,   mtDam↑, 1,   XIAP↓, 3,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AKT1↓, 1,   ALAT↓, 2,   AMPK↑, 1,   cMyc↓, 2,   FBP1↑, 1,   glucose↓, 1,   GlucoseCon↓, 2,   Glycolysis↓, 3,   HK2↓, 6,   lactateProd↓, 3,   LDH↓, 1,   LDL↓, 1,   PCK1↑, 1,   PDK1↓, 2,   PDK3↑, 1,   PGM1↑, 1,   PPARα↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 7,   p‑Akt↑, 1,   Apoptosis↓, 1,   Apoptosis↑, 18,   BAX↑, 3,   Bax:Bcl2↑, 1,   Bcl-2↓, 3,   Bcl-xL↓, 2,   Casp↑, 2,   Casp3↑, 8,   cl‑Casp3↑, 2,   Casp8↓, 1,   Casp8↑, 1,   cl‑Casp8↑, 1,   Casp9↑, 5,   cl‑Casp9↑, 2,   Cyt‑c↑, 4,   DR4↑, 1,   Fas↑, 1,   FasL↑, 1,   hTERT/TERT↓, 4,   iNOS↓, 2,   JNK↑, 2,   MAPK↓, 1,   MAPK↑, 2,   Mcl-1↓, 2,   p38↑, 1,   PUMA↑, 1,   survivin↓, 2,   TumCD↑, 6,   YAP/TEAD↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

HER2/EBBR2↓, 1,   p70S6↓, 1,   p‑p70S6↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↝, 3,   PhotoS↑, 1,   tumCV↓, 3,  

Protein Folding & ER Stress(tgid=8) ⓘ

eIF2α↑, 3,   p‑eIF2α↑, 1,   ER Stress↑, 7,   GRP78/BiP↑, 2,   GRP78/BiP↝, 1,   HSP70/HSPA5↑, 1,   PERK↑, 3,   UPR↑, 5,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

TumAuto↑, 3,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 1,   p‑ATM↑, 1,   DNAdam↑, 6,   P53↑, 1,   PARP↑, 1,   cl‑PARP↑, 4,   PCNA↓, 6,   γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 3,   CDK4↓, 1,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 5,   P21↑, 2,   TumCCA↑, 18,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

EMT↓, 4,   ERK↓, 1,   p‑ERK↑, 1,   GSK‐3β↑, 1,   HDAC↓, 3,   HDAC8↓, 1,   HMTs↓, 1,   Let-7↑, 1,   mTOR↓, 3,   NOTCH1↑, 4,   PI3K↓, 4,   PI3K↑, 1,   SCF↓, 1,   SHP1↑, 1,   STAT1↑, 1,   STAT3↓, 3,   p‑STAT3↓, 1,   p‑STAT3↑, 1,   TOP1↓, 2,   TumCG↓, 4,  

Migration(tgid=13) ⓘ

Ca+2↓, 1,   Ca+2↑, 5,   CDKN1C/p57↑, 1,   CLDN1↓, 2,   E-cadherin↑, 3,   p‑FAK↓, 1,   Fibronectin↓, 1,   Ki-67↓, 3,   MMP-10↓, 1,   MMP2↓, 4,   MMP9↓, 5,   MMP9↑, 1,   N-cadherin↓, 1,   PDGF↓, 1,   Rho↓, 1,   ROCK1↓, 1,   Slug↓, 1,   Snail↓, 1,   TET1↑, 4,   TIMP1↑, 2,   TIMP2↑, 1,   TumCI↓, 3,   TumCMig↓, 3,   TumCP↓, 13,   TumMeta↓, 6,   TumMeta↑, 1,   Twist↓, 3,   uPA↓, 1,   Vim↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 8,   ATF4↑, 2,   EGFR↓, 1,   EPR↑, 5,   Hif1a↓, 4,   VEGF↓, 5,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   GLUT1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX1↑, 1,   COX2/PTGS2↓, 5,   COX2/PTGS2↑, 1,   IL10↓, 1,   IL1β↓, 4,   IL2↑, 1,   IL6↓, 2,   IL8↓, 1,   Imm↑, 1,   Inflam↓, 3,   NF-kB↓, 5,   NK cell↑, 1,   PD-L1↓, 1,   PGE2↓, 3,   TLR4↓, 2,   TNF-α↓, 2,  

Cellular Microenvironment(tgid=17) ⓘ

cGAS–STING↑, 1,  

Protein Aggregation(tgid=19) ⓘ

NLRP3↑, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 3,   BioAv↑, 7,   ChemoSen↑, 11,   DDS↑, 3,   Dose↝, 4,   eff↓, 8,   eff↑, 36,   eff↝, 1,   Half-Life↓, 2,   Half-Life↑, 4,   RadioS↑, 4,   selectivity↑, 11,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 2,   ALP↓, 1,   AR↓, 1,   EGFR↓, 1,   HER2/EBBR2↓, 1,   hTERT/TERT↓, 4,   IL6↓, 2,   Ki-67↓, 3,   LDH↓, 1,   PD-L1↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 2,   AntiTum↑, 1,   cardioP↑, 1,   chemoP↑, 3,   chemoPv↑, 4,   neuroP↑, 2,   OS↑, 1,   RenoP↑, 1,   toxicity↓, 6,   TumVol↓, 3,   TumW↓, 1,   Weight∅, 1,  
Total Targets: 232

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

AntiArt↑, 1,   TMAO↑, 2,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 9,   Catalase↓, 1,   Catalase↑, 3,   GPx↓, 1,   GPx↑, 2,   GSH↑, 3,   GSR↑, 1,   GSTs↑, 2,   HDL↑, 2,   HO-1↑, 1,   Iron↑, 1,   lipid-P↓, 6,   MDA↓, 4,   NRF2↑, 2,   ROS↓, 23,   ROS↑, 1,   SOD↑, 4,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

MMP∅, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

LDL↓, 1,   lipidLev↓, 2,   NADPH↑, 2,   PPARα↑, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,   Apoptosis↓, 1,   Casp3↓, 1,   Casp9↓, 1,   iNOS↓, 1,   MAPK↓, 1,   MAPK↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↓, 1,   other↑, 2,   other↝, 4,  

Protein Folding & ER Stress(tgid=8) ⓘ

ER Stress↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 2,   P53↑, 1,   PCNA↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

PI3K↓, 1,   PTEN↑, 1,  

Migration(tgid=13) ⓘ

5LO↓, 1,   AntiAg↓, 1,   AntiAg↑, 3,   Ca+2↓, 1,   Ca+2↑, 1,   Cartilage↑, 1,   CLDN1↓, 1,   TGF-β1↓, 1,   TJ↓, 1,   ZO-1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

VEGF↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 4,   DCells↑, 1,   IL10↓, 1,   IL1β↓, 1,   IL2↓, 1,   Imm↑, 3,   Inflam↓, 10,   Inflam↑, 1,   NF-kB↓, 6,   TNF-α↓, 3,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 1,   BDNF↑, 2,   GABA↑, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,   Aβ↓, 1,   NLRP3↑, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

GR↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 6,   BioAv↑, 6,   BioAv⇅, 1,   Dose↝, 3,   eff↓, 1,   eff↑, 3,   P450↓, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AST↓, 1,   BP↓, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiDiabetic↑, 2,   cardioP↑, 6,   cardioP⇅, 1,   cardioP∅, 1,   chemoPv↑, 3,   cognitive↓, 2,   cognitive↑, 5,   hepatoP↑, 6,   memory↑, 4,   memory∅, 1,   neuroP↓, 1,   neuroP↑, 7,   Obesity↓, 2,   RenoP↑, 3,   Risk↓, 1,   toxicity↓, 3,   toxicity↝, 2,   Wound Healing↑, 2,  

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 1,  
Total Targets: 98

Scientific Paper Hit Count for: ROS, Reactive Oxygen Species
122 Silver-NanoParticles
99 Curcumin
95 Quercetin
91 Magnetic Fields
74 Thymoquinone
58 Resveratrol
56 Vitamin C (Ascorbic Acid)
55 Radiotherapy/Radiation
55 Shikonin
50 Berberine
50 Sulforaphane (mainly Broccoli)
47 Lycopene
47 Hydrogen Gas
45 EGCG (Epigallocatechin Gallate)
43 Baicalein
42 Alpha-Lipoic-Acid
40 Selenite (Sodium)
40 Ashwagandha(Withaferin A)
40 Piperlongumine
39 Selenium NanoParticles
38 Artemisinin
37 Betulinic acid
34 Rosmarinic acid
34 Fisetin
33 Capsaicin
32 Silymarin (Milk Thistle) silibinin
29 Chemotherapy
29 Propolis -bee glue
28 Cisplatin
28 Copper and Cu NanoParticles
28 Apigenin (mainly Parsley)
28 Honokiol
26 doxorubicin
26 Allicin (mainly Garlic)
26 Emodin
26 Gambogic Acid
25 Luteolin
25 Magnetic Field Rotating
25 Phenethyl isothiocyanate
23 Chlorogenic acid
23 Chrysin
22 Vitamin K2
21 chitosan
20 Coenzyme Q10
20 Juglone
19 isoquercitrin
19 isoorientin
18 Boron
18 Ferulic acid
17 salinomycin
17 Parthenolide
16 Urolithin
15 Caffeic acid
15 chaetocin
15 Ellagic acid
15 Eugenol
15 Isoliquiritigenin
14 Photodynamic Therapy
14 Auranofin
14 Boswellia (frankincense)
14 Carnosic acid
14 Carvacrol
14 Selenium
14 Crocetin
14 Phenylbutyrate
13 Dichloroacetate
13 Dandelion Root
13 Gallic acid
13 Pterostilbene
12 Melatonin
12 Graviola
12 HydroxyTyrosol
12 Isobavachalcone
12 VitK3,menadione
11 5-fluorouracil
11 Astaxanthin
11 Cinnamon
11 Cynaropicrin
11 Hyperthermia
11 Isovitexin
11 Piperine
10 Beta-Caryophyllene
10 α-Bisabolol / Chamomile oil
10 Ursolic acid
10 diet FMD Fasting Mimicking Diet
10 Hyperoside
10 Plumbagin
10 Nimbolide
9 SonoDynamic Therapy UltraSound
9 Andrographis
9 D-limonene
9 Bacopa monnieri
9 borneol
9 Centella asiatica / Gotu kola → asiaticoside
9 Hydroxycinnamic-acid
9 Diclofenac
9 Ginkgo biloba
8 3-bromopyruvate
8 Disulfiram
8 Electrical Pulses
8 Sulfasalazine
8 Methylene blue
8 Moringa oleifera
8 Propyl gallate
7 EMF
7 Gold NanoParticles
7 Gemcitabine (Gemzar)
7 Metformin
7 immunotherapy
7 Berbamine
7 brusatol
7 Carnosine
7 Celastrol
7 diet Methionine-Restricted Diet
7 eicosapentaenoic acid
7 Formononetin
7 Garcinol
7 Ginkgetin
6 2-DeoxyGlucose
6 Rutin
6 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
6 Anethole/trans-Anethole
6 Docetaxel
6 Biochanin A
6 Butyrate
6 Mung Bean Sprouts
6 Chlorophyllin
6 Chocolate
6 Citric Acid
6 Carvone
6 Cynara scolymus/Globe Artichoke/Artichoke Extract
6 Aflavin-3,3′-digallate
6 Fenbendazole
6 Fucoidan
6 HydroxyCitric Acid
6 Vitexin
5 1,8-Cineole
5 Brucea javanica
5 Bromelain
5 erastin
5 Thymol-Thymus vulgaris
5 Cichoric acid / Chicoric acid
5 Spermidine
5 Huperzine A/Huperzia serrata
5 Date Fruit Extract
5 Docosahexaenoic Acid
5 Evodiamine
5 Gossypol/AT-101
5 Magnolol
5 nicotinamide adenine dinucleotide
4 chemodynamic therapy
4 Zinc
4 Vitamin E
4 Cucurbitacin
4 diet Short Term Fasting
4 Ginkgo biloba-EGb 761
4 Geraniol
4 Ginkgolide B
4 Ginseng
4 γ-linolenic acid (Borage Oil)
4 Hibiscus sabdariffa
4 Inositol
4 Linalool
4 Magnesium
4 Naringin
4 Taurine
3 5-Aminolevulinic acid
3 Anthocyanins
3 Glucose
3 temozolomide
3 Black phosphorus
3 Paclitaxel/Taxol
3 Caffeic Acid Phenethyl Ester (CAPE)
3 Catechins
3 Choline
3 Dihydrocaffeic Acid
3 Oxygen, Hyperbaric
3 ferumoxytol
3 flavonoids
3 Shilajit/Fulvic Acid
3 Ginger/6-Shogaol/Gingerol
3 Grapeseed extract
3 Orlistat
3 IP6 (Inositol 1,2,3,4,5,6-hexakisphosphate)
3 MCToil
3 Methylsulfonylmethane
3 Mushroom Lion’s Mane
3 Myricetin
3 Oleuropein
3 α-Santalol/Sandalwood oil
3 Shankhpushpi
3 Terpinen-4-ol / Tea Tree Oil
3 Turmerones
3 Vitamin B1/Thiamine
2 5-Hydroxytryptophan
2 Astragalus
2 DTS(dibenzyl trisulphide) from Anamu
2 Fennel Oil/Foeniculum vulgare
2 Aromatherapy
2 Ascorbyl Palmitate
2 Atorvastatin
2 Aloe anthraquinones
2 beta-glucans
2 Baicalin
2 xanthohumol
2 Cannabidiol
2 beta-carotene(VitA)
2 Bufalin/Huachansu
2 Bruteridin(bergamot juice)
2 Cat’s Claw
2 Celecoxib
2 methotrexate
2 Carica papaya leaf extract
2 Calorie Restriction Mimetics
2 Galantamine
2 CUSP9
2 Folic Acid, Vit B9
2 Galloflavin
2 Germanium Organic/Ge-132 / propagermanium (organogermanium)
2 iodine
2 isoflavones
2 Potassium
2 Kaempferol
2 Methyl Jasmonate
2 Methylglyoxal
2 Vitamin B3,Niacin
2 Niclosamide (Niclocide)
2 Pachymic acid
2 Sanguinarine
2 Psoralidin
2 Radio Frequency
2 Rauwolfia serpentina/Indian Snakeroot
2 Sesame seeds and Oil
2 Iron
2 Salvia miltiorrhiza
2 triptolide
2 Vitamin D3
1 cetuximab
1 Annona atemoya Leaf Extract
1 Anzaroot, Astragalus fasciculifolius Bioss
1 entinostat
1 Camptothecin
1 Resiquimod
1 Ajoene (compound of Garlic)
1 Acetyl-l-carnitine
1 alpha Linolenic acid
1 Angelica archangelica / Garden Angelica
1 Anti-oxidants
1 Sorafenib (brand name Nexavar)
1 tamoxifen
1 almonertinib
1 epirubicin
1 Lapatinib
1 Ras-selective lethal 3
1 Chyawanprash
1 Aspirin
1 Rivastigmine
1 methylseleninic acid
1 Cyclopamine
1 Cysteamine
1 Dichloroacetophenone(2,2-)
1 Deguelin
1 diet Fermented Foods
1 diet Ketogenic
1 diet Plant based
1 Lemongrass Extract/Citral
1 Echinacea
1 Cannabichromene
1 Exercise
1 olaparib/LYNPARZA
1 verapamil
1 hydroxychloroquine
1 Ginkgolic acids
1 Genistein (soy isoflavone)
1 Germanium inorganic
1 hydrogen sulfide
1 Helleborus niger extracts – Christmas Rose
1 Rapamycin
1 Indole-3-carbinol
1 Inoscavin A
1 Butein
1 Scopoletin
1 Morin
1 Ivermectin
1 lambertianic acid
1 Myrrh
1 N-Acetyl-Cysteine
1 No Product/Mechanism Only
1 Oleocanthal
1 sericin
1 Polyphenols
1 benzo(a)pyrene
1 Rhein
1 Perilla
1 Salvia officinalis
1 Oxaliplatin
1 Scoulerine
1 polyethylene glycol
1 acetaminophen
1 Silicic Acid
1 Squalene
1 Osimertinib
1 Adagrasib
1 Glutathione
1 statins
1 Safflower yellow
1 Terminalia bellirica
1 Triphala
1 Vanillic Acid
1 Vitamin A, Retinoic Acid
1 Vitamin B12
1 Vitamin B2,Riboflavin
1 Vitamin B5,Pantothenic Acid
1 glucose deprivation
1 Transarterial Chemoembolization
1 probiotics
1 Zinc Oxide
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:275  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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