TumCCA Cancer Research Results

TumCCA, Tumor cell cycle arrest: Click to Expand ⟱
Source:
Type:
Tumor cell cycle arrest refers to the process by which cancer cells stop progressing through the cell cycle, which is the series of phases that a cell goes through to divide and replicate. This arrest can occur at various checkpoints in the cell cycle, including the G1, S, G2, and M phases. S, G1, G2, and M are the four phases of mitosis.
Scientific Papers found: Click to Expand⟱
8188- LGE,    Citral inhibits cell proliferation and induces apoptosis and cell cycle arrest in MCF-7 cells
- in-vitro, BC, MCF7
TumCG↓, TumCCA↑, Apoptosis↑, PGE2↓,
8187- LGE,    Modulation of oxidative stress and subsequent induction of apoptosis and endoplasmic reticulum stress allows citral to decrease cancer cell proliferation
- in-vitro, BC, 4T1 - in-vitro, Ovarian, OVCAR-3 - in-vitro, Ovarian, SKOV3
TumCP↓, TumCCA↑, Apoptosis↑, cl‑Casp3↑, BAX↑, Bcl-2↓, ER Stress↑, CHOP/DDIT3↑, GADD45A↑, EDEM↑, ATF4↑, HSP90↑, ATG5↑, eIF2α↑, ROS↑, P53↑, eff↓,
8292- lign,    Anticancer potential of flaxseed lignans, their metabolites and synthetic counterparts in relation with molecular targets: current challenges and future perspectives
- Review, Var, NA
*BioAv↝, chemoPv↑, Apoptosis↑, TumCP↓, TumMeta↓, angioG↓, *AntiDiabetic↑, *antiOx↑, *AntiCan↑, *Inflam↓, *cardioP↑, TumCCA↑, PSA↓, miR-106b↓, IGF-1↓, ERK↓, Akt↓, Bcl-2↓, p‑FAK↓, radioP↑, P-gp/ABCB1↓, ChemoSen↑, MMP↓, ROS↑, BioAv↓, *toxicity↓, chemoP↑,
8298- lign,    Inhibitory Effects of Enterolactone on Growth and Metastasis in Human Breast Cancer
- in-vitro, BC, MDA-MB-231
Risk↓, TumCP↓, Ki-67↓, PCNA↓, FOXM1↓, TumCCA↑, cycE/CCNE↓, cycA1/CCNA1↓, CycB/CCNB1↓, FAK↓, pax↓, TumCMig↓, TumCI↓,
8327- LIN,    Recent updates on bioactive properties of linalool
- Review, Var, NA
*AntiCan↑, *AntiBio↑, *neuroP↑, *Stress↓, *hepatoP↑, *RenoP↑, *ROS↓, ROS↑, *Inflam↓, *toxicity↓, TumCP↓, TumCCA↑, mtDam↑, MMP↓, compI↓, compII↓, ETC↓, ATP↓, angioG↓, ChemoSen↑, *GSH↑, *MDA↓, *lipid-P↓, *NRF2↑, *HO-1↑, *ALAT↓, *AST↓, chemoP↑,
8326- LIN,    Linalool in cancer pharmacology: pharmacokinetic limitations and preclinical cytotoxic evidence for translational development
- Review, Var, NA
Dose↝, *BioAv↓, BioAv↝, tumCV↓, compI↓, compII↓, ROS↑, ATP↓, GSH↓, mtDam↑, Casp↑, NF-kB↓, MMP↓, TumCCA↑, PI3K↓, Akt↓, angioG↓, CD31/PECAM-1↓, Ki-67↓,
8325- LIN,    Validating linalool as a potential drug for breast cancer treatment based on machine learning and molecular docking
- in-vitro, BC, NA
tumCV↓, TumCP↓, TumCMig↓, TumCI↓, Apoptosis↑, TumCCA↑, PPARγ↑, PGK1↓,
8321- LIN,  doxoR,    Linalool, a plant-derived monoterpene alcohol, reverses doxorubicin resistance in human breast adenocarcinoma cells
- in-vitro, BC, MCF7
ChemoSen↑, EPR↑, Bcl-xL↓, P-gp/ABCB1↓, TumCCA⇅, tumCV↓, Apoptosis↑,
8319- LIN,    Linalool monoterpene exerts potent antitumor effects in OECM 1 human oral cancer cells by inducing sub-G1 cell cycle arrest, loss of mitochondrial membrane potential and inhibition of PI3K/AKT biochemical pathway
- in-vitro, Oral, OECM-1 - in-vitro, Nor, FR-2
tumCV?, selectivity↑, Apoptosis↑, TumCCA↑, p‑PI3K↓, p‑Akt↓, MMP↓,
8318- LIN,    Linalool Exhibits Cytotoxic Effects by Activating Antitumor Immunity
- in-vitro, BC, T47D - NA, CRC, SW-620 - NA, Liver, HepG2
TumCCA↑, IFN-γ↓, IL13↓, IL2↓, IL4↓, IL6↓, TNF-α↓, Th1 response?,
8317- LIN,    Linalool induces cell cycle arrest and apoptosis in HepG2 cells through oxidative stress generation and modulation of Ras/MAPK and Akt/mTOR pathways
- in-vitro, Liver, HepG2
TumCP↓, TumCCA↑, CDK4↓, cycA1/CCNA1↓, P21↑, p27/CDKN1B↑, Apoptosis↑, MMP↓, Casp3↑, cl‑PARP↑, DNAdam↑, RAS↓, Akt↓, mTOR↓, ROS↑, MAPK↑,
6484- LIN,    Linalool Inhibits MCF-7 Tumor Growth in a Xenograft Model by Apoptosis Induction and Immune Modulation
- vitro+vivo, BC, MCF7
TumCG↓, Apoptosis↑, ROS↓, TumCCA↑,
6464- LIN,  1,8-Cin,    Anti-cancer mechanisms of linalool and 1,8-cineole in non-small cell lung cancer A549 cells
- in-vitro, NSCLC, A549 - in-vitro, Nor, WI38
TumCP↓, TumCCA↑, selectivity↑, ROS↑, MMP↓, eff↓, TumCMig↓, Synergy↑,
6480- LIN,    Linalool Induces Cell Cycle Arrest and Apoptosis in Leukemia Cells and Cervical Cancer Cells through CDKIs
- in-vitro, lymphoma, U937 - in-vitro, Var, HeLa
TumCD↑, TumCCA↑, P53↑, P21↑, p27/CDKN1B↑, p16↑, CDKN2C/p18↑,
6481- LIN,    Linalool inhibits 22Rv1 prostate cancer cell proliferation and induces apoptosis
- in-vivo, Pca, 22Rv1
TumCP↓, Apoptosis↑, Ki-67↓, PCNA↓, TumCCA↑, MMP↓, TumCG↓,
8375- LT,    Luteolin, a flavone ingredient: Anticancer mechanisms, combined medication strategy, pharmacokinetics, clinical trials, and pharmaceutical researches
- Review, Var, NA
TumCP↓, TumCI↓, Apoptosis↑, TumCCA↑, Inflam↓, Ferroptosis↑, Pyro↑, ChemoSen↑, chemoP↑, *BioAv↓, OATPs↓,
8395- LT,  PacT,    Luteolin enhances drug chemosensitivity by downregulating the FAK/PI3K/AKT pathway in paclitaxel‑resistant esophageal squamous cell carcinoma
- in-vitro, ESCC, NA
*AntiTum↑, TumCP↓, TumCCA↑, Apoptosis↑, TumCMig↓, EMT↓, ChemoSen↑, PI3K↓, Akt↓, FAK↓,
8384- LT,    Current situation and research progress of luteolin in the treatment of gastrointestinal malignant tumors
- Review, GC, NA
Apoptosis↑, TumAuto↑, TumCCA↑, EMT↓, *ROS↓, *antiOx↑, ROS↑, P53↑, LC3II↑, Beclin-1/ATG6↑, p‑MAP2K1/MEK1↓, p‑ERK↓, BAX↑, cl‑Casp3↑, Bcl-2↓, p‑MAPK↓, DNArepair↓, HMGB1↓, XRCC1↓, ERCC3↑, CycB/CCNB1↓, CDC2↓, p‑CHK1↑, TumCCA↑, TumCP?, Wnt↓, β-catenin/ZEB1↓, miR-384↑, PTN↓, MMP2↓, MMP3↓, MMP9↓, MMP16↓, Ferroptosis↑, GPx4↓, Synergy↑, Ki-67↓, GSH↓, ChemoSen↑, TumCP↓, TumCMig↓, TumCI↓, PI3K↓, Akt↓, mTOR↓, NF-kB↓, NOTCH↓, miR-139-5p↑, miR-34a↑, miR-422a↑, miR-107↑, miR-21↓, miR-155↓, miR-224↓, miR-340↓, E-cadherin↑, N-cadherin↓, Vim↓, HK1↓, FOXO1↓, compI↓, compIII↓, compV↓, ETC↓, BioAv↝,
8390- LT,    Luteolin in Inflammatory Bowel Disease and Colorectal Cancer: A Disease Continuum Perspective
- Review, IBD, NA - Review, CRC, NA
*Diff↝, *Inflam↓, *ROS↓, *GutMicro↑, *IBI↑, TumCP↓, Apoptosis↑, TumCMig↓, TumCI↓, *BioAv↑, *iNOS↓, *TNF-α↓, *IL6↓, *MDA↓, *lipid-P↓, *antiOx↑, *NRF2↑, *HO-1↑, *NQO1↑, *SOD↑, *Catalase↑, *5HT↓, *TPH1↓, *MAPK↓, *ERK↓, *Inflam↓, cycD1/CCND1↓, CDK4↓, TumCCA↑, Casp3↑, Casp9↑, PI3K↓, Akt↓, p‑Akt↓, p‑mTOR↓, E-cadherin↑, N-cadherin↓, Vim↓,
8402- LT,    Luteolin suppresses bladder cancer growth via regulation of mechanistic target of rapamycin pathway
- vitro+vivo, CRC, T24/HTB-9
tumCV↓, TumCCA↑, p‑S6↓, P21↑, Trx1↑, ROS↓, Ki-67↓, mTOR↓, TumCP↓,
8397- LT,    Effects and Mechanisms of Luteolin, a Plant-Based Flavonoid, in the Prevention of Cancers via Modulation of Inflammation and Cell Signaling Molecules
- Review, Var, NA
tumCV↓, TumCP↓, angioG↓, TumCI↓, TumMeta↓, mTOR↓, PI3K↓, Akt↓, STAT3↓, Wnt↓, β-catenin/ZEB1↓, TumCCA↑, Apoptosis↑, hTERT/TERT↓, AP-1↓, NF-kB↓, MAPK↓, HSP90↓, AR↓, IGF-1R↓, Akt↓, NOTCH↓, IL6↓, MMP2↓, MMP3↓, MMP9↓, MMP16↓, TumVol∅, TumW∅, miR-34a↑, miR-107↑, miR-139-5p↑, miR-422a↑, miR-21↓, miR-155↓, miR-224↓, miR-340↓, *toxicity↓,
1100- LT,    Luteolin, a flavonoid, as an anticancer agent: A review
- Review, Var, NA
TumCP↓, TumCCA↑, Apoptosis↑, EMT↓, E-cadherin↑, N-cadherin↓, Snail↓, Vim↓, ROS↑, ER Stress↑, mtDam↑, p‑eIF2α↝, p‑PERK↝, p‑CHOP/DDIT3↝, p‑ATF4↝, cl‑Casp12↝,
2906- LT,    Luteolin, a flavonoid with potentials for cancer prevention and therapy
- Review, Var, NA
*Inflam↓, AntiCan↑, antiOx⇅, Apoptosis↑, TumCP↓, TumMeta↓, angioG↓, PI3K↓, Akt↓, NF-kB↓, XIAP↓, P53↑, *ROS↓, *GSTA1↑, *GSR↑, *SOD↑, *Catalase↑, *other↓, ROS↑, Dose↝, chemoP↑, NF-kB↓, JNK↑, p27/CDKN1B↑, P21↑, DR5↑, Casp↑, Fas↑, BAX↑, MAPK↓, CDK2↓, IGF-1↓, PDGF↓, EGFR↓, PKCδ↓, TOP1↓, TOP2↓, Bcl-xL↓, FASN↓, VEGF↓, VEGFR2/KDR/Flk1↓, MMP9↓, Hif1a↓, FAK↓, MMP1↓, Twist↓, ERK↓, P450↓, CYP1A1↓, CYP1A2↓, TumCCA↑,
2909- LT,    Revisiting luteolin: An updated review on its anticancer potential
- Review, Var, NA
Apoptosis↑, TumCCA↑, angioG↓, TumMeta↓, TumCP↓, chemoP↑, MDR1↓,
2912- LT,    Luteolin: a flavonoid with a multifaceted anticancer potential
- Review, Var, NA
ROS↑, TumCCA↑, TumCP↓, angioG↓, ER Stress↑, mtDam↑, PERK↑, ATF4↑, eIF2α↑, cl‑Casp12↑, EMT↓, E-cadherin↑, N-cadherin↓, Vim↓, *neuroP↑, NF-kB↓, PI3K↓, Akt↑, XIAP↓, MMP↓, Ca+2↑, BAX↑, Casp3↑, Casp9↑, Bcl-2↓, Cyt‑c↑, IronCh↑, SOD↓, *ROS↓, *LDHA↑, *SOD↑, *GSH↑, *BioAv↓, Telomerase↓, cMyc↓, hTERT/TERT↓, DR5↑, Fas↑, FADD↑, BAD↑, BOK↑, BID↑, NAIP↓, Mcl-1↓, CDK2↓, CDK4↓, MAPK↓, AKT1↓, Akt2↓, *Beclin-1/ATG6↓, Hif1a↓, LC3II↑, Beclin-1/ATG6↑,
2913- LT,    Luteolin induces apoptosis by impairing mitochondrial function and targeting the intrinsic apoptosis pathway in gastric cancer cells
- in-vitro, GC, HGC27 - in-vitro, BC, MCF7 - in-vitro, GC, MKN45
TumCP↓, MMP↓, Apoptosis↑, ROS↑, SOD↓, ATP↓, Bax:Bcl2↑, TumCCA↑,
2922- LT,    Combination of transcriptomic and proteomic approaches helps unravel the mechanisms of luteolin in inducing liver cancer cell death via targeting AKT1 and SRC
- in-vitro, Liver, HUH7
Half-Life↝, TumCCA↑, AKT1↓, ATF2↓, NF-kB↓, GSK‐3β↓, cMyc↓, GSTs↓, TrxR1↓, ROS↑,
2916- LT,    Antioxidative and Anticancer Potential of Luteolin: A Comprehensive Approach Against Wide Range of Human Malignancies
- Review, Var, NA - Review, AD, NA - Review, Park, NA
proCasp9↓, CDC2↓, CycB/CCNB1↓, Casp9↑, Casp3↑, Cyt‑c↑, cycA1/CCNA1↑, CDK2↓, APAF1↑, TumCCA↑, P53↑, BAX↑, VEGF↓, Bcl-2↓, Apoptosis↑, p‑Akt↓, p‑EGFR↓, p‑ERK↓, p‑STAT3↓, cardioP↑, Catalase↓, SOD↓, *BioAv↓, *antiOx↑, *ROS↓, *NO↓, *GSTs↑, *GSR↑, *SOD↑, *Catalase↑, *lipid-P↓, PI3K↓, Akt↓, CDK2↓, BNIP3↑, hTERT/TERT↓, DR5↑, Beclin-1/ATG6↑, TNF-α↓, NF-kB↓, IL1↓, IL6↓, EMT↓, FAK↓, E-cadherin↑, MDM2↓, NOTCH↓, MAPK↑, Vim↓, N-cadherin↓, Snail↓, MMP2↓, Twist↓, MMP9↓, ROS↑, MMP↓, *AChE↓, *MMP↑, *Aβ↓, *neuroP↑, Trx1↑, ROS↓, *NRF2↑, NRF2↓, *BBB↑, ChemoSen↑, GutMicro↑, *antiAll↑, *Mucositis↓, *TregCell↑, *Beclin-1/ATG6↓, *PI3K↑, *Akt↑, *mTOR↑,
1171- LT,    The inhibition of β-catenin activity by luteolin isolated from Paulownia flowers leads to growth arrest and apoptosis in cholangiocarcinoma
- in-vitro, CCA, NA
Wnt↓, TumCCA↑, Apoptosis↑, TumCMig↓, β-catenin/ZEB1↓, cMyc↓, cycD1/CCND1↓,
8346- Lut,    Lutein inhibits tumor progression through the ATR/Chk1/p53 signaling pathway in non-small cell lung cancer
- vitro+vivo, NSCLC, A549
TumCP↓, TumCCA↑, Apoptosis↑, P53↑, DNAdam↑, ATR↑, CHK1↑, TumCG↓, OS↑,
8347- Lut,    Carotenoid Lutein Selectively Inhibits Breast Cancer Cell Growth and Potentiates the Effect of Chemotherapeutic Agents through ROS-Mediated Mechanisms
- in-vitro, BC, NA
TumCG↓, TumCCA↑, selectivity↑, ROS↑, eff↓, P53↑, HSP60/HSPD1↑, cycF↑, CDC25↑, CDK6↑, ANAPC2↑, AURKB↑, GADD45A↑, BAX↑, Casp3↑, CASP4↑, Casp8↑, TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, DR6↑, ChemoSen↑,
3275- Lyco,    Multifaceted Effects of Lycopene: A Boulevard to the Multitarget-Based Treatment for Cancer
- Review, Var, NA
TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, P21↑, P53↑, GSK‐3β↓, p27/CDKN1B↓, Akt↓, mTOR↓, ROS↓, MMPs↓, TumCI↓, TumCMig↓, NF-kB↓, *iNOS↓, *COX2/PTGS2↓, lipid-P↓, GSH↑, NRF2↑,
1708- Lyco,    The Anti-Cancer Activity of Lycopene: A Systematic Review of Human and Animal Studies
- Review, Var, NA
OS↑, ChemoSen↑, QoL↑, PSA∅, Synergy↑, AntiCan↑, AntiCan↑, angioG↓, VEGF↓, Hif1a↓, SOD↑, Catalase↑, GPx↑, GSH↑, GPx↑, GR↑, MDA↓, NRF2↑, HO-1↑, COX2/PTGS2↓, PGE2↓, NF-kB↓, IL4↑, IL10↑, IL6↓, TNF-α↓, PPARγ↑, TumCCA↑, FOXO3↓, Casp3↑, IGF-1↓, p27/CDKN1B↑, STAT3↓, CDK2↓, CDK4↓, P21↑, PCNA↓, MMP7↓, MMP9↓,
8414- Lyco,    Exploring the Therapeutic Potential of Lycopene: Mechanisms, Biological Activities, and Health Benefits
- Review, Var, NA - Review, AD, NA
*ROS↓, *Inflam↓, *hepatoP↑, *cardioP↑, *neuroP↑, *AntiArt↑, *Obesity↓, *Wound Healing↑, *BioAv↑, *GSTs↑, *Trx1↑, *SOD↑, *Catalase↑, *ALAT↓, *LDH↓, *AST↓, *MDA↓, *cognitive↑, *memory↑, *NeuroI↓, *Aβ↓, *LRP1↑, *RAGE↓, *NRF2↑, *HO-1↑, tumCV?, Bax:Bcl2↑, DNAdam↑, Apoptosis↑, β-catenin/ZEB1↓, cMyc↓, cycD1/CCND1↓, ROS↓, TumCCA↑, Akt↓, *Synergy↑, *MDA↓, *NF-kB↓, *TGF-β↓, *Casp3↓, *Catalase↑, *GSH↑, *Bcl-2↑, *IL10↑, *MUC1↑, *IBI↑, *RenoP↑, *ChemoSen↑, *Synergy↑, *Synergy↑, *BMD↑,
8407- Lyco,    Lycopene induces cell growth inhibition by altering mevalonate pathway and Ras signaling in cancer cell lines
- in-vitro, Pca, LNCaP
CholSyn↓, HMGCR↓, RAS↓, NF-kB↓, ROS↓, p‑Jun↓, TumCCA↑, Apoptosis↑, cycD1/CCND1↓, p‑Akt↓, P21↑, p27/CDKN1B↑, P53↑, Bax:Bcl2↑,
4778- Lyco,    Lycopene exerts cytotoxic effects by mitochondrial reactive oxygen species–induced apoptosis in glioblastoma multiforme
- in-vitro, GBM, GBM8401
BBB↑, Apoptosis↑, TumCP↑, P53↑, CycB/CCNB1↓, cycD1/CCND1↓, TumCCA↓, mt-ROS↑, TumCG↓,
4780- Lyco,    Potential inhibitory effect of lycopene on prostate cancer
- Review, Pca, NA
TumCP↓, TumCCA↑, Apoptosis↑, *neuroP↑, *NF-kB↓, *JNK↓, *NRF2↑, *BDNF↑, *Ca+2↝, *antiOx↑, *AntiCan↑, *Inflam↓, *IL1↓, *IL6↓, *IL8↓, *TNF-α↓, NF-kB↓, DNAdam↓, PSA↓, P53↓, cycD1/CCND1↓, NRF2↓, Akt2↓, PPARγ↓,
4783- Lyco,    Lycopene suppresses gastric cancer cell growth without affecting normal gastric epithelial cells
- in-vitro, GC, AGS - in-vitro, GC, SGC-7901 - in-vitro, Nor, GES-1
TumCG↓, TumCCA↑, Apoptosis↑, MMP↓, selectivity↑, cycE1↓, TP53↑, *antiOx↑,
4786- Lyco,    Anti-proliferative and apoptosis-inducing activity of lycopene against three subtypes of human breast cancer cell lines
- in-vitro, BC, MDA-MB-468 - in-vitro, BC, MCF7 - in-vitro, BC, SkBr3
TumCP↓, TumCCA↑, cl‑PARP↑, ERK↑, cycD1/CCND1↓, P21↓, p‑Akt↓, mTOR↓, BAX↑, AntiCan↑, Risk↓,
4791- Lyco,    Investigating into anti-cancer potential of lycopene: Molecular targets
- Review, Var, NA
*antiOx↑, TumCP↓, TumCCA↓, Apoptosis↑, TumCI↓, angioG↓, TumMeta↓, *Risk↓, cycD1/CCND1↓, CycD3↓, cycE/CCNE↓, CDK2↓, CDK4↓, Bcl-2↓, P21↑, p27/CDKN1B↑, P53↑, BAX↑, selectivity↑, MMP↓, Cyt‑c↑, Wnt↓, Synergy↑, PPARγ↑, LDL↓, Akt↓, PI3K↓, mTOR↓, PDGF↓, NF-kB↓, ChemoSen↑,
4799- Lyco,    Anticancer Properties of Lycopene
- Review, Var, NA
Risk↓, TumCG↓, *antiOx↑, *Inflam↓, TumCP↓, TumCCA↑,
4797- Lyco,    A mechanistic updated overview on lycopene as potential anticancer agent
- Review, Var, NA
AntiCan↑, antiOx↓, Apoptosis↑, TumCP↓, TumCCA↑, Risk↓, ROS↓, SOD↑, Catalase↑, GSTs↑, ARE↑, NRF2↑, cycD1/CCND1↓, cycE/CCNE↑, CDK2↑, p27/CDKN1B↑, BAX↑, Bcl-2↓, P53↑, ChemoSen↑,
4795- Lyco,    Updates on the Anticancer Profile of Lycopene and its Probable Mechanism against Breast and Gynecological Cancer
- Review, BC, NA
TumCG↓, TumCCA↑, Apoptosis↑, P53↝, BAX↝, cycD1/CCND1↓, ERK↓, Akt↓, STAT3↓, NRF2↝, NF-kB↓, ITGB1↓, ITGA5↓, FAK↓, MMP9↓, EMT↓,
4794- Lyco,    Anticancer Effect of Lycopene in Gastric Carcinogenesis
- Review, GC, NA
*AntiCan↑, *ROS↓, *GSH↑, *GPx↑, *GSTs↑, TumCG↓, Apoptosis↑, ERK↓, Bcl-2↓, BAX↑, Cyt‑c↑, TumCCA↑, *DNAdam↓,
2545- M-Blu,    Reversing the Warburg Effect as a Treatment for Glioblastoma
- in-vitro, GBM, U87MG - NA, AD, NA - in-vitro, GBM, A172 - in-vitro, GBM, T98G
Warburg↓, OCR↑, lactateProd↓, TumCP↓, TumCCA↑, AMPK↑, ACC↓, Cyc↓, neuroP↑, Cyt‑c↝, Glycolysis↓, ECAR↓, TumCG↓, other↓,
2540- M-Blu,    Alternative mitochondrial electron transfer for the treatment of neurodegenerative diseases and cancers: Methylene blue connects the dots
- Review, Var, NA - Review, AD, NA
*OCR↑, *Glycolysis↓, *GlucoseCon↑, neuroP↑, Warburg↓, mt-OXPHOS↑, TumCCA↑, TumCP↓, ROS⇅, *cognitive↑, *mTOR↓, *mt-antiOx↑, *memory↑, *BBB↑, *eff↝, *ECAR↓, eff↑, lactateProd↓, NADPH↓, OXPHOS↑, AMPK↑, selectivity↑,
5252- MAG,    Insights on the Multifunctional Activities of Magnolol
- Review, Var, NA
BioAv↓, *Inflam↓, *Bacteria↓, *antiOx↑, *neuroP↑, *cardioP↑, CYP1A1↓, *PPARγ↑, *NF-kB↓, *COX2/PTGS2↓, *iNOS↓, *ROS↓, Apoptosis↑, TumCCA↑, cycD1/CCND1↓, cycA1/CCNA1↓, CDK2↓, P21↑, TumCG↓, TumCMig↓, TumCI↓, Ki-67↓, PCNA↓, MMP2↓, MMP9↓, MMP7↓, DNAdam↑, MMP↓, TumCP↓, selectivity↑, PI3K↓, Akt↓, H2O2↓, Hif1a↓, *BDNF↑, *NRF2↑, *AChE↑,
1196- MAG,    2-O-Methylmagnolol, a Magnolol Derivative, Suppresses Hepatocellular Carcinoma Progression via Inhibiting Class I Histone Deacetylase Expression
- in-vitro, HCC, NA
TumCG↓, TumCMig↓, TumCI↓, TumCCA↑, HDAC↓,
8523- MAG,    Anticancer potential of magnolol for lung cancer treatment
- in-vitro, Lung, A549
TumCG↓, LDH↑, TumCCA↑, Casp3↑, cl‑PARP↑, NF-kB↓,
8519- MAG,    Magnolol inhibits growth of gallbladder cancer cells through the p53 pathway
- vitro+vivo, Gall, NA
TumCG?, TumCCA↑, mt-Apoptosis↑, P53↑, P21↑, cycD1/CCND1↓, CDC25↓, CDK2↓, MMP↓, Bax:Bcl2↑, Casp9↑, Casp3↑, cl‑PARP↑,

Showing Research Papers: 751 to 800 of 1163
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1163

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 2,  

Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↑, 1,   antiOx↓, 6,   antiOx↑, 25,   antiOx⇅, 2,   ARE↑, 1,   ARE/EpRE↑, 1,   Catalase↓, 14,   Catalase↑, 7,   Copper↑, 1,   DJ-1↓, 1,   ENOX2↓, 1,   Fenton↑, 4,   GCLM↓, 1,   GPx↓, 3,   GPx↑, 5,   GPx1↓, 2,   GPx4↓, 20,   GPx4∅, 1,   GSH?, 1,   GSH↓, 65,   GSH↑, 10,   GSH⇅, 1,   GSH/GSSG↓, 3,   GSR↓, 2,   GSR↑, 1,   GSSG↓, 1,   GSTs↓, 4,   GSTs↑, 2,   GSTs↝, 1,   H2O2↓, 1,   H2O2↑, 10,   HO-1↓, 6,   HO-1↑, 25,   HO-2↓, 1,   Iron↓, 3,   Iron↑, 8,   Iron↝, 1,   i-Iron↑, 2,   c-Iron↑, 1,   Keap1↓, 1,   Keap1↑, 2,   lipid-P↓, 5,   lipid-P↑, 33,   MDA↓, 6,   MDA↑, 13,   i-MDA↑, 1,   NADH↓, 2,   mt-NADH↓, 1,   mt-NADH↑, 1,   NOX4↑, 1,   NQO1?, 1,   NQO1↓, 4,   NQO1↑, 4,   Nrf1↑, 1,   NRF2↓, 29,   NRF2↑, 34,   NRF2⇅, 1,   NRF2↝, 1,   Prx↓, 2,   Prx4↑, 1,   Prx6↑, 1,   PrxII↓, 2,   PYCR1↓, 1,   RNS↑, 2,   ROS?, 3,   ROS↓, 51,   ROS↑, 534,   ROS⇅, 11,   ROS↝, 4,   ROS∅, 4,   i-ROS?, 1,   i-ROS↓, 1,   i-ROS↑, 5,   mt-ROS↑, 9,   SOD?, 1,   SOD↓, 16,   SOD↑, 11,   SOD1↓, 2,   SOD1↑, 1,   SOD2↓, 5,   mt-SOD2↑, 1,   TBARS↓, 1,   TBARS↑, 1,   Thiols↓, 2,   TKT↓, 1,   Trx↓, 7,   Trx↑, 1,   Trx1↓, 1,   Trx1↑, 2,   ox-Trx1↑, 1,   TrxR↓, 12,   TrxR↑, 1,   TrxR1↓, 8,   TrxR1↑, 1,   xCT/SLC7A11↓, 5,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 2,   FTH1↓, 2,   IronCh↑, 3,   Mets↑, 1,   NCOA4↑, 1,   Tf↓, 1,   Tf↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↑, 1,   BCR↓, 1,   BCR-ABL↓, 1,   CDC16↓, 1,   CDC2↓, 12,   p‑CDC2↓, 1,   CDC25↓, 30,   CDC25↑, 2,   CDC25↝, 1,   p‑CDC25↑, 1,   compI↓, 4,   compII↓, 2,   compIII↓, 1,   compV↓, 1,   EGF↓, 6,   EGF↑, 1,   ETC↓, 7,   HSP60/HSPD1↓, 2,   HSP60/HSPD1↑, 1,   IDH2↓, 1,   Insulin↓, 1,   MFN2↑, 1,   mitResp↓, 6,   mitResp↑, 2,   MKK7↓, 1,   Mortalin↓, 1,   mtDam↓, 3,   mtDam↑, 44,   OCR↓, 6,   OCR↑, 2,   mt-OCR↑, 1,   OXPHOS↓, 5,   OXPHOS↑, 5,   mt-OXPHOS↓, 1,   mt-OXPHOS↑, 1,   PDH↓, 1,   PDH↑, 4,   PINK1↑, 1,   SIRT3↓, 3,   SIRT3↑, 3,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 6,   5LO↓, 5,   ACC↓, 1,   ACC↑, 3,   p‑ACC↑, 1,   ACLY↓, 2,   ACSL4↑, 2,   ALAT↓, 10,   ALDOA↓, 2,   AMP↓, 1,   AMP↑, 1,   AMPK?, 1,   AMPK↓, 3,   AMPK↑, 37,   AMPK↝, 1,   p‑AMPK↑, 2,   p‑AMT/GCST/T-protein↑, 1,   ATP↓, 40,   ATP↑, 1,   mt-ATP↓, 1,   CAIX/CA9↓, 4,   CholSyn↓, 1,   ECAR↓, 4,   ECAR↑, 1,   ECAR↝, 1,   ENO1↓, 3,   FABP4↓, 1,   FASN↓, 9,   G6PD↓, 2,   GAPDH↓, 2,   GLO-I↓, 2,   GLS↓, 2,   glucoNG↓, 1,   glucose↓, 1,   glucose↝, 1,   GlucoseCon↓, 18,   GlucoseCon∅, 1,   glut↓, 1,   GlutaM↓, 1,   GlutMet↓, 1,   Glycolysis↓, 51,   GSK‐3β↓, 15,   GSK‐3β↑, 9,   p‑GSK‐3β↓, 9,   H2S↑, 1,   Histones↑, 2,   HK1↓, 2,   HK2↓, 26,   HMG-CoA↓, 1,   IDH1↑, 1,   IDO1↓, 1,   lactateProd↓, 23,   lactateProd↑, 1,   lactateProd∅, 1,   LDHA↓, 17,   LDL↓, 4,   lipidLev↓, 1,   lipoGen↓, 1,   MCT4↓, 2,   NADPH↓, 4,   NADPH↑, 2,   PCK1↓, 1,   PDK1 / PDPK1?, 2,   PDK1 / PDPK1↓, 11,   PDK3↑, 1,   PDKs↓, 1,   PFK↓, 4,   PFK1↓, 1,   PGK1↓, 1,   PKM1↑, 1,   PKM2↓, 21,   PKM2↑, 1,   PKM2∅, 1,   PLA2↓, 1,   PPP↓, 2,   Pyrim↓, 1,   Pyruv↓, 1,   Pyruv↑, 1,   p‑S6↓, 2,   SCD1↓, 2,   SIRT1↓, 10,   SIRT1↑, 5,   SLC25A1↓, 1,   SREBF2↓, 1,   SREBP1/SREBF1↓, 2,   SREBP2↓, 1,   TCA↓, 2,   TCA↑, 1,   TS↓, 2,   Warburg↓, 10,  

Cell Death(tgid=5) ⓘ

AIF↑, 22,   APAF1↑, 11,   Apoptosis?, 2,   Apoptosis↓, 12,   Apoptosis↑, 657,   mt-Apoptosis↑, 11,   ASC↓, 1,   ASC↑, 1,   ASK1↑, 3,   p‑ASK1↑, 1,   BAD↓, 3,   BAD↑, 23,   p‑BAD↓, 1,   Bak↓, 1,   Bak↑, 14,   BAX↓, 6,   BAX↑, 251,   BAX↝, 3,   Bax:Bcl2↑, 67,   Bcl-2↓, 276,   Bcl-2↑, 8,   Bcl-2↝, 2,   Bcl-2∅, 1,   Bcl-xL↓, 70,   Bcl-xL↑, 1,   BID↓, 1,   BID↑, 12,   p‑BID↓, 1,   cl‑BID↑, 1,   BIM↑, 10,   BNIP3↑, 4,   BNIP3↝, 1,   BOK↑, 1,   BTG3↑, 1,   Casp↓, 4,   Casp↑, 73,   Casp↝, 2,   Casp∅, 1,   cl‑Casp↑, 3,   Casp1↓, 2,   Casp1↑, 3,   proCasp1↓, 1,   Casp10↓, 1,   Casp10↑, 3,   Casp12?, 1,   Casp12↑, 5,   cl‑Casp12↑, 2,   cl‑Casp12↝, 1,   Casp2↑, 2,   Casp3↓, 6,   Casp3↑, 295,   Casp3↝, 2,   cl‑Casp3↑, 65,   cl‑Casp3⇅, 1,   proCasp3↓, 3,   proCasp3↑, 3,   pro‑Casp3↑, 1,   CASP4↑, 1,   Casp6↓, 1,   Casp6↑, 3,   Casp7↑, 32,   cl‑Casp7↑, 7,   Casp8↓, 3,   Casp8↑, 66,   Casp8∅, 1,   cl‑Casp8↑, 11,   proCasp8↑, 3,   Casp9↓, 2,   Casp9↑, 171,   p‑Casp9↑, 1,   cl‑Casp9↑, 21,   proCasp9↓, 2,   proCasp9↑, 3,   cFLIP↓, 8,   Cyt‑c↓, 4,   Cyt‑c↑, 162,   Cyt‑c↝, 5,   mt-Cyt‑c↓, 1,   Diablo↑, 10,   DR5↓, 1,   DR5↑, 36,   Endon↑, 2,   FADD↑, 9,   Fap1↓, 1,   Fas↓, 1,   Fas↑, 34,   FasL↑, 18,   FasL⇅, 1,   Ferroptosis↑, 31,   GSDME↑, 1,   cl‑GSDME↑, 2,   HEY1↓, 1,   IAP1↓, 14,   IAP1↑, 1,   IAP2/BIRC3↓, 3,   IAP2/BIRC3↑, 1,   cl‑IAP2/BIRC3↑, 1,   ICAD↑, 1,   ICD↑, 1,   iNOS↓, 18,   iNOS↑, 1,   Mcl-1↓, 34,   Mcl-1↑, 1,   p‑Mcl-1↓, 1,   MDM2↓, 16,   MLKL↑, 2,   MOMP↓, 1,   MOMP↑, 8,   NAIP↓, 1,   Necroptosis↑, 6,   necrosis↑, 6,   NOXA↑, 6,   oncosis↑, 1,   P2X7↓, 1,   p38↓, 7,   p38↑, 31,   p‑p38↓, 5,   p‑p38↑, 7,   PUMA↓, 1,   PUMA↑, 10,   Pyro↑, 7,   RIP1↓, 2,   RIP3↑, 2,   p‑RIP3↑, 1,   survivin↓, 80,   TNFR 1↑, 2,   TRAIL↑, 6,   TRAILR↑, 2,   TumCD?, 1,   TumCD↓, 2,   TumCD↑, 61,   TUNEL↑, 2,   XIAP?, 1,   XIAP↓, 38,   XIAP↑, 1,   YAP/TEAD↓, 6,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 245,   Akt↑, 9,   Akt↝, 1,   p‑Akt↓, 69,   p‑Akt↑, 2,   AKT1↓, 6,   Akt2↓, 3,   AMPKα↑, 4,   BRAF↓, 1,   CaMKII ↓, 1,   CDC7↓, 1,   CIP2A↓, 1,   CK2↓, 7,   cMET↓, 3,   p‑cMET↑, 1,   CREB↓, 1,   cSrc↓, 2,   DDIT4↑, 1,   EF-1α↓, 1,   EGFR↓, 56,   EGFR↑, 1,   p‑EGFR↓, 6,   ERK↓, 67,   ERK↑, 18,   ERK↝, 2,   p‑ERK↓, 20,   p‑ERK↑, 7,   p‑ERK⇅, 1,   FGFR1↓, 4,   FGFR2↓, 1,   FOXD3↑, 1,   HCAR2↑, 1,   HER2/EBBR2↓, 23,   IGF-1R↓, 2,   IGFR↓, 3,   IKKα↓, 10,   p‑IKKα↓, 2,   IκB↓, 1,   IκB↑, 1,   p‑IκB↓, 2,   JAK↓, 7,   JAK1?, 1,   JAK1↓, 6,   JAK1↑, 1,   p‑JAK1↓, 2,   JAK2↓, 20,   p‑JAK2↓, 5,   p‑JAK3↓, 1,   JNK↓, 7,   JNK↑, 42,   JNK↝, 2,   p‑JNK↓, 4,   p‑JNK↑, 5,   LATS1↓, 1,   LIMK1↓, 1,   MAP2K1/MEK1↓, 1,   p‑MAP2K1/MEK1↓, 1,   MAPK?, 1,   MAPK↓, 57,   MAPK↑, 30,   MAPK↝, 4,   p‑MAPK↓, 2,   p‑MAPK↑, 2,   MARK4↓, 2,   MEK↓, 7,   p‑MEK↓, 2,   MKK4↓, 1,   MKP1↓, 1,   MKP2↓, 1,   Mst1↑, 1,   mTOR↓, 116,   mTOR↑, 3,   mTOR↝, 2,   p‑mTOR↓, 15,   mTORC2↓, 5,   p42↓, 1,   p70S6↓, 6,   p70S6↑, 1,   p‑p70S6↓, 1,   p‑p70S6↑, 1,   P70S6K↓, 7,   p‑P70S6K↓, 2,   p85S6K↓, 1,   P90RSK↓, 1,   p‑P90RSK↑, 1,   PDGFR-BB↓, 1,   PDGFRA↓, 1,   PDGFRB↓, 1,   PI3K↓, 176,   PI3K↑, 6,   PI3K↝, 2,   p‑PI3K↓, 8,   p‑PI3K↑, 1,   PI3K/Akt↓, 7,   PI3K/Akt↑, 1,   PI3k/Akt/mTOR↓, 6,   PIK3CA↓, 1,   PKA↓, 1,   PKCδ↓, 14,   PP2A↑, 1,   PRAS40↑, 1,   PRKCG↑, 1,   PTEN↓, 1,   PTEN↑, 33,   p‑PTEN↓, 1,   Raf↓, 5,   e-Raf↓, 1,   c-Raf↓, 1,   RAS↓, 17,   RET↓, 1,   RPS6KA1↓, 1,   p‑S6K↓, 1,   SHP1↓, 1,   SHP1↑, 3,   Sp1/3/4↓, 16,   Src↓, 1,   Src↑, 1,   STAT↓, 5,   STAT3↓, 120,   STAT3↑, 6,   STAT3↝, 1,   p‑STAT3↓, 28,   p‑STAT3↑, 2,   STAT5↓, 4,   STAT6↓, 4,   STK11/LKB1↑, 1,   p‑STK11/LKB1↑, 2,   THEM4/CTMP↑, 1,   TK1↓, 1,   TSC2↑, 4,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 2,   ATF2↓, 1,   ATF3↑, 2,   ATF4↓, 1,   ATF4↑, 19,   ATF4↝, 1,   p‑ATF4↝, 1,   ATFs↑, 1,   BRD4↓, 1,   CBP↓, 3,   CBP↑, 1,   ChrMod↑, 3,   ChrMod↝, 1,   cJun↓, 8,   cJun↑, 4,   p‑cJun↑, 1,   cMyc↓, 65,   cMyc↑, 2,   DNMT1↓, 15,   DNMT1↑, 1,   DNMT3A↓, 3,   DNMT3B↓, 2,   DNMTs↓, 11,   EZH2↓, 2,   FOXM1↓, 8,   FOXO↑, 1,   FOXO1↓, 2,   FOXO1↑, 3,   FOXO3↓, 8,   FOXO3↑, 8,   FOXO3↝, 1,   FOXO4↓, 2,   GATA3↓, 1,   H3↓, 2,   H3↑, 4,   p‑H3↓, 2,   p‑H3↑, 1,   ac‑H3↑, 10,   H3K27ac↓, 1,   H3K4↓, 1,   H4↑, 2,   ac‑H4↑, 7,   ac‑H4∅, 1,   HATs↓, 6,   HATs↑, 2,   HDAC↓, 48,   HDAC1↓, 9,   HDAC10↓, 1,   HDAC2↓, 7,   HDAC3↓, 7,   HDAC4↓, 2,   HDAC8↓, 4,   HMTs↓, 2,   JHDM1D-AS1↓, 1,   KLF4↓, 1,   miR-106b↓, 1,   miR-107↑, 2,   miR-122-5p↑, 1,   miR-126↑, 1,   miR-133a-3p↑, 1,   miR-134↑, 1,   miR-139-5p↑, 2,   miR-149↑, 1,   miR-155↓, 4,   miR-195↑, 1,   miR-199↓, 1,   miR-199↑, 1,   miR-19b↓, 1,   miR-203↓, 1,   miR-203↑, 1,   miR-206↑, 1,   miR-21↓, 8,   miR-21↑, 2,   miR-210↑, 1,   miR-215-5p↑, 1,   miR-218↑, 1,   miR-22↑, 1,   miR-221↑, 1,   miR-222↑, 1,   miR-224↓, 2,   miR-25-5p↓, 1,   miR-27a-3p↓, 2,   miR-29b↑, 1,   miR-30a-5p↑, 1,   miR-326-5p↑, 1,   miR-339-5p↑, 1,   miR-339-5p↝, 1,   miR-340↓, 2,   miR-34a↑, 11,   miR-34b-5p↑, 1,   miR-384↑, 1,   miR-422a↑, 2,   MTA2↓, 1,   Myc↓, 6,   Myc↑, 1,   MYCN↓, 1,   n-MYC↓, 2,   NDRG1↑, 1,   NNMT↓, 1,   OCT4↓, 16,   other?, 2,   other↓, 9,   other↑, 7,   other↝, 25,   other∅, 2,   OV6↓, 1,   PAX2↓, 1,   PCAF↓, 1,   PhotoS↑, 4,   PRC2↓, 1,   PRMT6↓, 1,   SBF2-AS1↓, 1,   Set9↑, 1,   sonoS↑, 1,   SOX2↓, 15,   SOX4↓, 4,   SOX4↑, 1,   SUV39H↓, 3,   TBX3↑, 1,   TCF-4↓, 2,   TFE3↑, 1,   tumCV?, 2,   tumCV↓, 152,   tumCV↑, 1,   tumCV∅, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 2,   cl‑ATF6↑, 1,   CHOP/DDIT3↑, 41,   p‑CHOP/DDIT3↝, 1,   cl‑CHOP/DDIT3↑, 1,   EDEM↑, 1,   eIF2α↓, 3,   eIF2α↑, 11,   p‑eIF2α↑, 6,   p‑eIF2α↝, 1,   ER Stress↓, 4,   ER Stress↑, 85,   ER Stress↝, 1,   ERStress↑, 1,   GRP78/BiP?, 1,   GRP78/BiP↓, 3,   GRP78/BiP↑, 19,   GRP94↑, 1,   HSF1↓, 2,   HSP27↓, 8,   HSP27↑, 3,   HSP27↝, 1,   HSP70/HSPA5↓, 8,   HSP70/HSPA5↑, 5,   HSP70/HSPA5↝, 1,   HSP90↓, 24,   HSP90↑, 2,   HSPs↓, 3,   IRE1↑, 4,   PDI↑, 1,   PERK↓, 1,   PERK↑, 12,   p‑PERK↑, 1,   p‑PERK↝, 1,   UPR↑, 16,   XBP-1↑, 2,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG13↑, 2,   ATG16L1↑, 1,   ATG3↑, 2,   ATG5↓, 1,   ATG5↑, 11,   ATG7↑, 2,   AVOs↑, 1,   Beclin-1/ATG6↓, 6,   Beclin-1/ATG6↑, 20,   CTSB↓, 2,   CTSD↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 4,   LC3A↑, 2,   LC3B↓, 1,   LC3B↑, 2,   LC3B-II↓, 1,   LC3B-II↑, 4,   LC3II↓, 2,   LC3II↑, 13,   LC3s↑, 2,   LC3s↝, 1,   MitoP↓, 1,   p62↓, 9,   p62↑, 7,   PARK2↑, 1,   RUBCN↓, 1,   SESN2↑, 4,   TumAuto↓, 4,   TumAuto↑, 84,   TumAuto⇅, 1,   TumAuto↝, 2,   ULK1/ATG1↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 11,   p‑ATM↑, 2,   ATR↑, 4,   p‑ATR↑, 1,   BRCA1↓, 1,   BRCA1↑, 3,   p‑BRCA1↑, 1,   BRCA2↓, 1,   BRCA2↑, 1,   CUL4B↑, 1,   DFF45↑, 2,   DNA-PK↑, 1,   DNAdam↓, 6,   DNAdam↑, 160,   mt-DNAdam↑, 1,   DNArepair↓, 8,   ERCC3↑, 1,   m-FAM72A↓, 1,   G9a↓, 2,   HR↓, 1,   hTERT/TERT↓, 17,   MDMX↓, 1,   MGMT↓, 2,   MSH2↑, 1,   NHEJ↓, 1,   p16↑, 7,   P53?, 1,   P53↓, 9,   P53↑, 213,   P53↝, 3,   p‑P53↓, 2,   p‑P53↑, 5,   ac‑P53↑, 1,   p53 Wildtype↓, 1,   p53 Wildtype∅, 1,   p73↑, 1,   PARP↓, 9,   PARP↑, 36,   PARP↝, 1,   p‑PARP↑, 1,   cl‑PARP↓, 2,   cl‑PARP↑, 143,   PARP1↓, 1,   PARP1↑, 5,   cl‑PARP1↑, 3,   PCNA↓, 48,   PCNA↑, 1,   PCNA↝, 1,   POLD1↓, 1,   RAD51↓, 1,   SIRT6↓, 3,   SIRT6↑, 1,   Telomerase↓, 15,   TOP1?, 1,   TOP1↓, 8,   TOP2↓, 7,   TP53↑, 4,   TRF2↓, 2,   UHRF1↓, 2,   XRCC1↓, 1,   γH2AX↑, 26,   γH2AX↝, 1,   p‑γH2AX↑, 3,  

Cell Cycle & Senescence(tgid=11) ⓘ

ANAPC2↑, 1,   AURKB↑, 1,   BRD4↓, 1,   CC(CDKs/cyclins)↓, 2,   CDK1↓, 45,   CDK1↑, 7,   CDK1↝, 1,   p‑CDK1↓, 1,   CDK1/2/5/9∅, 1,   CDK2↓, 90,   CDK2↑, 6,   p‑CDK2↓, 1,   CDK4↓, 114,   CDK4↑, 5,   p‑CDK4↓, 1,   CDK4/6↓, 3,   CDK6↓, 35,   CDK6↑, 6,   CDK8↓, 2,   CDKN1C/p57↓, 1,   CDKN1C/p57↑, 1,   CDKN2C/p18↑, 2,   cellSen↑, 2,   CHK1↓, 4,   CHK1↑, 4,   CHK1↝, 1,   p‑CHK1↑, 4,   Chk2↓, 2,   Chk2↑, 9,   p‑Chk2↑, 2,   ChrCon↑, 1,   Cyc↓, 8,   cycA1/CCNA1↓, 33,   cycA1/CCNA1↑, 5,   CycB/CCNB1↓, 74,   CycB/CCNB1↑, 10,   CycB/CCNB1↝, 1,   cycD1/CCND1↓, 220,   cycD1/CCND1↑, 6,   cycD1/CCND1↝, 1,   p‑cycD1/CCND1↓, 1,   CycD3↓, 4,   CycD3↑, 1,   cycE/CCNE↓, 63,   cycE/CCNE↑, 5,   cycE1↓, 4,   cycF↓, 1,   cycF↑, 1,   E2F4↑, 1,   E2Fs↓, 10,   FBXO5/EMI1↓, 1,   GADD45A↑, 5,   Ki-67↓, 49,   mitA↑, 4,   p19↑, 3,   P21?, 2,   P21↓, 10,   P21↑, 193,   P21↝, 1,   p27/CDKN1B↓, 7,   p27/CDKN1B↑, 75,   cl‑p27/CDKN1B↓, 1,   PLK1↓, 1,   pRB↓, 5,   pRB↑, 1,   p‑pRB↓, 7,   RB1↑, 6,   p‑RB1↓, 10,   cl‑RB1↓, 1,   Securin↓, 2,   TumCCA?, 8,   TumCCA↓, 29,   TumCCA↑, 1128,   TumCCA⇅, 1,   TumCCA∅, 1,   WEE1↑, 3,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

4E-BP1↓, 3,   p‑4E-BP1↓, 2,   ALDH↓, 5,   ALDH1A1↓, 4,   AXIN1↓, 1,   Axin2↓, 1,   Axin2↑, 1,   BMI1↓, 1,   BMP7/OP1↓, 3,   BMPs↑, 1,   CD133↓, 17,   CD24↓, 3,   CEBPA↑, 1,   cFos↓, 6,   cFos↑, 1,   cMYB↓, 3,   CSCs?, 1,   CSCs↓, 68,   CSCs↑, 1,   Diff↓, 1,   Diff↑, 7,   EIF4E↓, 2,   EP300↑, 1,   EP4/PTGER4↑, 1,   FGF↓, 4,   Gli1↓, 12,   HH?, 1,   HH↓, 12,   HMGCR↓, 3,   IGF-1?, 1,   IGF-1↓, 12,   IGF-1↑, 1,   p‑IGF-1↓, 1,   IGFBP3↑, 4,   IGFBP7↑, 1,   p‑Jun↓, 1,   Ki-67↓, 49,   Let-7↑, 5,   LGR5↓, 1,   mTORC1↓, 6,   p‑mTORC1↓, 1,   Nanog↓, 17,   Nestin↓, 3,   NF2↑, 1,   NKD2↑, 1,   NOTCH↓, 22,   NOTCH1↓, 17,   NOTCH1↑, 3,   NOTCH2↓, 1,   NOTCH3↓, 4,   OGFr↑, 1,   p300↓, 5,   PTCH1↓, 1,   SAL↑, 1,   SCF↓, 1,   Shh↓, 15,   Smo↓, 5,   Smo∅, 1,   STAT1↓, 1,   Sufu↑, 1,   TOPflash↓, 1,   TumCG?, 4,   TumCG↓, 244,   TumCG↑, 3,   TumCP?, 2,   TumCP↓, 396,   TumCP↑, 8,   tyrosinase↓, 2,   URGCP/URG4↓, 1,   Wnt↓, 60,   Wnt↝, 1,   Wnt/(β-catenin)↓, 15,   ZFX↓, 1,  

Migration(tgid=13) ⓘ

67LR↓, 1,   annexin II↓, 1,   AntiAg↓, 1,   AntiAg↑, 3,   AP-1↓, 17,   APC↑, 1,   ATPase↓, 2,   AXL↓, 1,   BACH1↓, 1,   CA↓, 2,   Ca+2↓, 3,   Ca+2↑, 57,   Ca+2↝, 4,   i-Ca+2↑, 4,   CAFs/TAFs↓, 1,   cal2↑, 2,   CCN2/CTGF↓, 2,   CD11b↑, 1,   Cdc42↑, 1,   Chl↑, 1,   Cofilin↓, 2,   COL1↓, 1,   COL1A1↓, 1,   COL3A1↓, 2,   E-cadherin↓, 12,   E-cadherin↑, 58,   E-cadherin↝, 1,   EMT?, 1,   EMT↓, 104,   EMT↑, 2,   EMT↝, 1,   EpCAM↓, 6,   F-actin↓, 2,   FAK↓, 19,   FAK↑, 1,   p‑FAK↓, 7,   p‑FAK↑, 1,   fascin↓, 1,   Fibronectin↓, 3,   GIT1↓, 1,   GLI2↓, 1,   ITGA5↓, 2,   ITGB1↓, 2,   ITGB1↑, 1,   ITGB4↓, 2,   KRAS↓, 2,   LAMs↓, 3,   LEF1↓, 3,   MALAT1↓, 1,   MET↓, 2,   MMP-10↓, 2,   MMP1↓, 8,   MMP13↓, 3,   MMP16↓, 2,   MMP2↓, 124,   MMP3↓, 10,   MMP7↓, 14,   MMP9↓, 152,   MMP9↑, 2,   MMP9:TIMP1↓, 1,   MMPs↓, 47,   MTA1↓, 1,   MUC1↓, 1,   MUC1-C↓, 1,   MUC4↓, 4,   N-cadherin?, 1,   N-cadherin↓, 36,   N-cadherin↑, 1,   N-cadherin↝, 1,   NCAM↓, 2,   NCAM↑, 1,   NEDD9↓, 2,   NFAT↑, 1,   p44↓, 1,   PAK1↓, 3,   pax↓, 1,   p‑pax↓, 1,   PCBP1↓, 1,   PDGF↓, 6,   Rac1↓, 1,   RECK↑, 1,   Rho↓, 3,   ROCK1↓, 7,   ROCK1↑, 1,   Slug?, 1,   Slug↓, 9,   Smad1↓, 1,   Smad1↑, 1,   Smad1↝, 1,   SMAD2↓, 4,   p‑SMAD2↓, 1,   SMAD3↓, 6,   SMAD3↑, 1,   p‑SMAD4↓, 1,   Snail?, 1,   Snail↓, 21,   STAC2↓, 1,   T-cadherin↑, 1,   TET1↓, 1,   TET1↑, 5,   TGF-β↓, 24,   TGF-β↑, 1,   TGF-β↝, 1,   TGF-β1↓, 1,   THBS1↓, 1,   THBS1↑, 1,   TIMP1↓, 2,   TIMP1↑, 11,   TIMP2↓, 3,   TIMP2↑, 12,   TPM4↓, 1,   pol-TregCell↓, 1,   TRIB3↑, 1,   Trop2↓, 1,   TSC1↑, 2,   TSP-1↑, 4,   TumCA↓, 1,   TumCI↓, 152,   TumCI↑, 2,   TumCMig?, 1,   TumCMig↓, 161,   TumCMig↑, 2,   TumMeta↓, 129,   TumMeta↑, 9,   Twist↓, 18,   TXNIP↑, 1,   uPA↓, 25,   uPAR↓, 4,   Vim?, 1,   Vim↓, 42,   Vim↑, 1,   Zeb1↓, 13,   ZEB2↓, 2,   α-SMA↓, 2,   α-tubulin↓, 4,   β-catenin/ZEB1↓, 74,   β-catenin/ZEB1↑, 3,   p‑β-catenin/ZEB1↓, 1,   cl‑β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 160,   angioG↑, 3,   CCN1/CYR61↓, 1,   CD31/PECAM-1↓, 5,   ECM/TCF↓, 1,   EGR1↓, 1,   Endoglin↑, 2,   eNOS↓, 3,   HIF-1↓, 10,   Hif1a↓, 90,   Hif1a↑, 2,   LOX1↓, 2,   NO↓, 6,   NO↑, 7,   VCAM-1↓, 3,   VEGF↓, 153,   VEGF↑, 1,   VEGFR1↓, 3,   VEGFR2/KDR/Flk1↓, 23,   p‑VEGFR2/KDR/Flk1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

AQPs↓, 1,   BBB↑, 7,   BBB∅, 1,   CellMemb↑, 1,   CLDN1↓, 2,   CLDN1↑, 1,   CLDN2↓, 2,   CTR1↑, 1,   EPR↑, 14,   GLUT1↓, 16,   GLUT2↓, 2,   GLUT4↓, 6,   IBI↑, 1,   memfluid↓, 1,   MMP?, 1,   MMP↓, 264,   MMP↑, 3,   MMP∅, 1,   MPT↑, 9,   NHE1↓, 2,   OATPs↓, 2,   OCLN↑, 1,   SLC12A5↓, 1,   SVCT-2∅, 1,   TJ↑, 1,   TRPM7↓, 3,   TRPM7↑, 1,   TRPV1↑, 4,   TRPV1↝, 1,   ZO-1↓, 1,   ZO-1↑, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

B2M↓, 1,   CB2 / CNR2↑, 3,   CCR7↓, 1,   CD155↓, 1,   CD25+↑, 1,   CD4+↓, 1,   CD4+↑, 4,   CD44↓, 20,   CD44↝, 1,   CD47↓, 1,   CD8+↑, 4,   cDC2↓, 8,   p‑cDC2↓, 2,   p‑cDC2↑, 1,   COX1↓, 2,   COX2/PTGS2↓, 109,   COX2/PTGS2↑, 4,   COX2/PTGS2↝, 2,   CXCL12↓, 2,   CXCL9↓, 1,   CXCR2↓, 2,   CXCR2↑, 1,   CXCR4↓, 13,   DCells↑, 2,   DR4↑, 9,   DR4∅, 1,   DR6↑, 1,   FOXP3↓, 1,   FOXP3↑, 2,   Gal-3↓, 2,   HCAR2↑, 1,   HMGB1↓, 5,   ICAM-1↓, 6,   IFN-γ↓, 6,   IFN-γ↑, 2,   Igs↑, 2,   IL1↓, 7,   IL1↑, 1,   IL10↓, 3,   IL10↑, 3,   IL12↑, 1,   IL13↓, 1,   IL17↓, 1,   IL1α↓, 1,   IL1β↓, 21,   IL1β↑, 1,   IL2↓, 3,   IL2↑, 4,   IL4↓, 1,   IL4↑, 1,   IL6↓, 53,   IL6↑, 1,   IL8↓, 12,   IL8↑, 1,   Imm↑, 28,   Imm↝, 3,   Inflam↓, 53,   Inflam↝, 1,   IRAK1↓, 1,   M2 MC↓, 1,   MCP1/CCL2↓, 3,   MCT1↓, 2,   MIP2↓, 1,   MyD88↑, 1,   NAF1↓, 1,   NF-kB?, 1,   NF-kB↓, 220,   NF-kB↑, 8,   NF-kB↝, 1,   p‑NF-kB↓, 2,   p‑NF-kB↑, 2,   NK cell↑, 11,   NLRP3↓, 3,   NLRP3↑, 2,   NOD1↓, 1,   p65↓, 9,   p65↑, 1,   p‑p65↓, 4,   ac‑p65↓, 1,   ac‑p65↑, 2,   PD-1↓, 2,   PD-L1↓, 12,   PD-L1↑, 3,   PGE2↓, 22,   PSA↓, 20,   PSA∅, 1,   RAGE↓, 2,   SOCS-3↓, 1,   SOCS-3↑, 1,   T-Cell↑, 2,   TCF↓, 4,   Th1 response?, 1,   Th1 response↑, 1,   TLR4↓, 5,   TLR4↑, 1,   TLR4↝, 1,   TNF-α↓, 41,   TNF-α↑, 8,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 4,   TRADD↑, 1,   Treg lymp↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

ADAM17↓, 1,   pH↓, 1,   i-pH↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   CAXII/CA12↑, 1,   PTN↓, 1,  

Protein Aggregation(tgid=19) ⓘ

APOE4↑, 1,   BACE/β-secretase↓, 1,   PSEN1/PS1↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

2/16-OHE1↑, 1,   4-OHE1↓, 1,   6IL↑, 1,   ACE/ACE1↓, 1,   AhR↓, 2,   AhR↑, 1,   AR↓, 22,   AR↑, 1,   COMT↓, 1,   ER-α36↓, 4,   ER(estro)↓, 2,   ER(estro)↑, 1,   ERα/ESR1↓, 3,   ERβ/ESR2↑, 1,   Estro↝, 1,   EstroRS/ERS↓, 1,   FGF21↓, 1,   GR↑, 1,   PPARγ↓, 2,   PPARγ↑, 9,   PRL↓, 1,   RANKL↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 3,   AKR1B10↓, 1,   BioAv↓, 63,   BioAv↑, 58,   BioAv↝, 12,   BioEnh↑, 6,   CBR1↓, 1,   chemoR↓, 1,   ChemoSen↓, 4,   ChemoSen↑, 271,   ChemoSen∅, 1,   CompStab?, 1,   CompStab↓, 1,   CompStab↑, 4,   CompStab↝, 1,   CYP1A1↓, 5,   CYP1A1↑, 3,   CYP1A2↓, 1,   CYP1B1↓, 1,   CYP3A4↓, 2,   DDS↑, 1,   Dose?, 5,   Dose↓, 3,   Dose↑, 10,   Dose⇅, 3,   Dose↝, 98,   Dose∅, 12,   eff↓, 110,   eff↑, 148,   eff↝, 17,   eff∅, 3,   GSTA1↓, 2,   GSTA1↑, 1,   GSTP1/GSTπ↓, 1,   Half-Life↓, 19,   Half-Life↑, 4,   Half-Life↝, 16,   Half-Life∅, 2,   MDR1↓, 13,   MRP1/ABCC1↓, 6,   NAT↓, 1,   P-gp/ABCB1↓, 31,   P-gp/ABCB1∅, 1,   P450↓, 5,   P450↝, 1,   RadioS?, 1,   RadioS↓, 1,   RadioS↑, 84,   RadioS↝, 1,   selectivity?, 4,   selectivity↓, 2,   selectivity↑, 190,   selectivity∅, 1,   Synergy↑, 136,  

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 1,   ALAT↓, 10,   ALP↓, 4,   AR↓, 22,   AR↑, 1,   AST↓, 7,   B2M↓, 1,   BRAF↓, 1,   BRCA1↓, 1,   BRCA1↑, 3,   p‑BRCA1↑, 1,   CEA↓, 1,   CRP↓, 2,   E6↓, 4,   E7↓, 3,   EGFR↓, 56,   EGFR↑, 1,   p‑EGFR↓, 6,   ERα/ESR1↓, 3,   EstroRS/ERS↓, 1,   EZH2↓, 2,   Ferritin↓, 2,   FOXM1↓, 8,   HER2/EBBR2↓, 23,   hTERT/TERT↓, 17,   IL6↓, 53,   IL6↑, 1,   KRAS↓, 2,   LDH↓, 9,   LDH↑, 6,   LDH↝, 3,   i-LDH↓, 1,   Maspin↑, 1,   Myc↓, 6,   Myc↑, 1,   PD-L1↓, 12,   PD-L1↑, 3,   PSA↓, 20,   PSA∅, 1,   RAGE↓, 2,   TP53↑, 4,   TRIB3↑, 1,   Tumccf↓, 1,   XIST↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiCan↓, 3,   AntiCan↑, 107,   AntiCan?, 1,   AntiDiabetic↑, 2,   antiNeop↑, 4,   AntiTum↓, 1,   AntiTum↑, 40,   Appetite↑, 1,   BowelM↑, 1,   breath↑, 1,   cachexia↓, 1,   cardioP↑, 13,   CardioT↓, 2,   CardioT↑, 2,   chemoP↑, 43,   chemoPv↑, 33,   ChemoSideEff↓, 6,   cognitive↑, 1,   fatigue↓, 1,   fatigue∅, 1,   FTO↑, 1,   hepatoP↓, 2,   hepatoP↑, 15,   hepatoP∅, 1,   K17↓, 1,   kidSt↓, 1,   memory↑, 1,   Mucositis↓, 1,   neuroP↑, 14,   NP/CIPN↓, 1,   Obesity↓, 1,   Obesity↑, 1,   OS?, 1,   OS↑, 26,   OS⇅, 1,   Pain↓, 4,   PFS↑, 1,   Pin1↓, 3,   QoL↑, 10,   QoL∅, 2,   radioP↑, 11,   Remission↑, 1,   RenoP↑, 8,   Risk↓, 25,   Sleep↑, 2,   Strength↑, 2,   TGFβR1↑, 1,   toxicity?, 1,   toxicity↓, 31,   toxicity↑, 6,   toxicity↝, 9,   toxicity∅, 5,   TumVol↓, 50,   TumVol↑, 2,   TumVol∅, 1,   TumW↓, 21,   TumW∅, 1,   Weight↑, 3,   Weight∅, 2,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↓, 1,   AntiFungal↑, 1,   AntiViral↑, 1,   Bacteria↓, 4,   Bacteria↑, 1,   GutMicro↑, 8,   GutMicro↝, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,   Ingr↝, 5,  
Total Targets: 1394

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx?, 1,   antiOx↓, 6,   antiOx↑, 126,   mt-antiOx↑, 1,   ARE↑, 2,   Catalase↑, 48,   Copper↓, 1,   GPx↓, 1,   GPx↑, 35,   GPx1↑, 1,   GPx4↑, 2,   GSH↑, 40,   GSR↑, 6,   GSSG↓, 1,   GSTs↑, 21,   H2O2↓, 3,   HDL↓, 1,   HDL↑, 4,   HNE↓, 1,   HO-1↓, 1,   HO-1↑, 21,   Iron↓, 2,   i-Iron↓, 1,   Keap1↓, 3,   Keap1↑, 1,   Keap1↝, 1,   lipid-P↓, 44,   MDA↓, 33,   MPO↓, 5,   NADH↓, 1,   NOX4↓, 1,   NQO1↑, 4,   Nrf1↑, 1,   NRF2↓, 1,   NRF2↑, 51,   Prx↑, 1,   RNS↓, 3,   ROS?, 2,   ROS↓, 117,   ROS↑, 8,   ROS↝, 1,   ROS∅, 4,   mt-ROS?, 1,   selenoP↑, 1,   SOD↓, 1,   SOD↑, 51,   SOD1↑, 3,   SOD2↑, 1,   TAC↑, 6,   TBARS↓, 3,   Trx1↑, 1,   uricA↓, 2,   VitC↑, 2,   xCT/SLC7A11↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↓, 1,   IronCh↑, 4,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

DRP1/DNM1L↓, 1,   HSP60/HSPD1↓, 1,   Insulin↓, 1,   Insulin↑, 2,   MFN2↑, 1,   mitResp↑, 1,   OCR↑, 1,   PGC-1α↑, 1,   PGC-1α↝, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

15-LOX/ALOX15↓, 1,   5LO↓, 4,   ALAT↓, 12,   AMPK↑, 9,   p‑AMPK↑, 1,   ATP↑, 4,   CRM↑, 1,   DGAT1↓, 1,   ECAR↓, 1,   ECAR∅, 1,   FASN↓, 2,   glucose↓, 6,   glucose↝, 1,   GlucoseCon↑, 2,   glyC↓, 1,   Glycolysis↓, 1,   Glycolysis↑, 1,   GSK‐3β↓, 4,   GSK‐3β↑, 2,   H2S↑, 2,   HK2↑, 1,   LDHA↑, 1,   LDL↓, 6,   lipidLev↓, 2,   NADPH↑, 2,   SIRT1↑, 4,   SIRT1↝, 1,  

Cell Death(tgid=5) ⓘ

AIF↓, 1,   AIF↑, 1,   Apoptosis↓, 6,   Apoptosis↑, 1,   ASC↓, 1,   BAX↓, 8,   BAX↑, 1,   Bax:Bcl2↑, 2,   Bcl-2↓, 1,   Bcl-2↑, 4,   Casp↓, 1,   Casp1↓, 1,   Casp3?, 1,   Casp3↓, 11,   Casp3↑, 2,   cl‑Casp3↑, 1,   Casp8↑, 1,   cl‑Casp8↑, 2,   Casp9↓, 3,   Casp9↑, 1,   cl‑Casp9↑, 1,   Cyt‑c↓, 4,   Cyt‑c↑, 1,   Fas↓, 2,   Fas↑, 2,   FasL↓, 1,   Ferroptosis↓, 3,   IAP1↓, 1,   iNOS↓, 18,   iNOS↑, 1,   necrosis↓, 1,   p38↓, 1,   p38↑, 1,   survivin↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 4,   Akt↑, 3,   Akt↝, 1,   p‑Akt↑, 1,   p‑CREB↑, 1,   ERK↓, 2,   ERK↑, 2,   p‑ERK↑, 1,   IκB?, 1,   JAK↓, 1,   JNK↓, 3,   JNK↑, 3,   MAPK↓, 8,   MAPK↑, 1,   mTOR↓, 3,   mTOR↑, 2,   PDGFR-BB↓, 1,   PDGFRB↓, 1,   PI3K↓, 6,   PI3K↑, 2,   PKCδ↓, 1,   PTEN↑, 1,   STAT↓, 3,   STAT3↓, 2,   STAT3↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 5,   ATF2↑, 1,   cJun↓, 1,   cMyc↓, 1,   p‑cMyc↑, 1,   FOXO3↑, 1,   HDAC↓, 1,   HDAC3↓, 1,   other?, 1,   other↓, 2,   other↑, 5,   other↝, 7,   RUNX2↑, 1,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 1,   cl‑eIF2α↑, 1,   GRP78/BiP↑, 1,   HSP27↓, 1,   HSP70/HSPA5↓, 1,   HSP70/HSPA5↑, 3,   HSPs↑, 1,   p‑PERK↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 2,   Beclin-1/ATG6↑, 1,   LC3II↑, 1,   p62↑, 2,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 5,   DNArepair↑, 1,   p16↓, 1,   P53↓, 3,   P53↑, 4,   PARP↑, 1,   cl‑PARP↑, 2,   PARP1↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1,   CDK2↓, 1,   cycA1/CCNA1↓, 1,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 2,   cycE/CCNE↑, 1,   Ki-67↓, 1,   P21↓, 3,   P21↑, 5,   TumCCA↑, 9,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMP2↑, 1,   Diff↑, 1,   Diff↝, 1,   HH↓, 1,   IGF-1↓, 1,   IGFBP3↑, 1,   Ki-67↓, 1,   neuroG↑, 1,   TumCP↓, 2,   Wnt↑, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 12,   AP-1↓, 3,   BACH1↓, 1,   Ca+2↓, 2,   Ca+2↑, 1,   Ca+2↝, 1,   Cartilage↑, 1,   COL1↑, 1,   FAK↑, 1,   LAMs↑, 1,   LRP1↑, 1,   MMP13↓, 2,   MMP9↓, 5,   MUC1↑, 1,   Smad1↑, 1,   TGF-β↓, 4,   TIMP1↓, 1,   TregCell↑, 1,   TumCI↓, 1,   TumCI∅, 1,   TumCMig∅, 1,   α-SMA↓, 1,   β-catenin/ZEB1↑, 1,   β-catenin/ZEB1↝, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 2,   angioG↑, 1,   E-sel↓, 1,   Hif1a↓, 2,   NO↓, 10,   NO↑, 1,   VCAM-1↓, 3,   VEGF↓, 3,   VEGF↑, 2,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 9,   BBB↝, 2,   GastroP↑, 6,   GLUT4↑, 2,   H+/K+-ATPase↓, 1,   IBI↑, 3,   MMP↓, 3,   MMP↑, 9,   MMP∅, 1,   MUC5AC↓, 1,   TRPA1↑, 1,   TRPC1↓, 1,   TRPM7↓, 1,   TRPV1↑, 1,   VGSC↓, 1,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CCL11↓, 1,   CD19↑, 1,   CD4+↑, 2,   CD8+↑, 1,   COX1↓, 4,   COX2/PTGS2↓, 35,   COX2/PTGS2↑, 1,   CXCR4↓, 1,   HMGB1↓, 1,   ICAM-1↓, 2,   IFN-γ↓, 3,   IFN-γ↑, 2,   IL1↓, 2,   IL10↓, 3,   IL10↑, 5,   IL12↓, 1,   IL17↓, 5,   IL18↓, 3,   IL1β↓, 21,   IL2↓, 1,   IL2↑, 1,   IL22↓, 1,   IL23↓, 1,   IL5↓, 1,   IL6?, 1,   IL6↓, 29,   IL6↑, 1,   IL8↓, 8,   Imm↑, 6,   Imm⇅, 2,   Inflam?, 1,   Inflam↓, 121,   Inflam↑, 4,   IRF3↓, 2,   pol-M2 MC↑, 1,   MCP1/CCL2↓, 2,   MyD88↓, 2,   NeuroI↓, 1,   NF-kB?, 1,   NF-kB↓, 41,   NF-kB↑, 1,   NK cell↑, 1,   NLRP3↓, 5,   NLRP3↑, 1,   PGE2↓, 15,   PGE2↑, 1,   RAGE↓, 2,   SOCS-3↓, 1,   TLR2↓, 3,   TLR4↓, 7,   TNF-α?, 1,   TNF-α↓, 37,   TNF-α↑, 2,   TRIF↓, 1,   β-HEX↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 2,   5HT↑, 2,   AChE↓, 17,   AChE↑, 1,   BChE↓, 3,   BDNF↑, 10,   GABA↑, 3,   GABA↝, 1,   MAOA↓, 2,   NGF↑, 3,   TPH1↓, 1,   TrkB↑, 2,   β-Endo↑, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 5,   Aβ↓, 19,   BACE/β-secretase↓, 6,   tau↓, 4,   p‑tau↓, 3,   XO↓, 2,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 1,   ACE2↓, 1,   AHR↓, 1,   CYP19↓, 1,   GPER↑, 1,   GR↑, 1,   PPARα↝, 1,   PPARγ↓, 2,   PPARγ↑, 2,   p‑PPARγ↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv?, 1,   BioAv↓, 50,   BioAv↑, 45,   BioAv↝, 22,   BioEnh↑, 2,   ChemoSen↑, 1,   CompStab↑, 1,   CompStab↝, 2,   CYP1A1↑, 1,   CYP1A2↑, 1,   CYP2D6↓, 1,   CYP2E1↓, 1,   Dose↑, 1,   Dose⇅, 1,   Dose↝, 10,   eff↓, 1,   eff↑, 11,   eff↝, 2,   GSTA1↓, 1,   GSTA1↑, 2,   Half-Life↓, 3,   Half-Life↑, 2,   Half-Life↝, 11,   Half-Life∅, 2,   P450↓, 3,   Synergy↑, 13,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 12,   ALP↓, 4,   AST↓, 15,   BloodF↑, 1,   BMD↑, 5,   BP↓, 9,   creat↓, 4,   CRP↓, 3,   HOMA↓, 1,   hs-CRP↓, 1,   IL6?, 1,   IL6↓, 29,   IL6↑, 1,   IRes↑, 1,   IRes↝, 1,   LDH↓, 7,   NOS2↓, 1,   RAGE↓, 2,   TC↓, 2,   TG/TAG↓, 2,   Urea↓, 1,   VLDL↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 7,   antiAll↑, 18,   AntiArt↑, 9,   AntiCan↓, 2,   AntiCan↑, 25,   antiCG↑, 1,   AntiDiabetic↓, 2,   AntiDiabetic↑, 31,   antiNeop↑, 2,   antiPs↑, 1,   AntiTum↓, 2,   AntiTum↑, 3,   Bone Healing↑, 1,   cardioP?, 1,   cardioP↓, 1,   cardioP↑, 53,   CardioT↓, 1,   chemoP↑, 10,   chemoPv↑, 7,   cognitive↑, 17,   cough?, 1,   diuretic↑, 1,   hepatoP↑, 43,   Learn↑, 1,   memory↑, 19,   motorD↑, 3,   Mucositis↓, 1,   neuroP↓, 1,   neuroP↑, 82,   Obesity↓, 15,   OS↑, 1,   Pain↓, 9,   radioP↑, 4,   RenoP↓, 1,   RenoP↑, 12,   Risk↓, 1,   SoreThr?, 1,   Stress↓, 2,   Stroke↓, 11,   toxicity?, 2,   toxicity↓, 56,   toxicity↑, 6,   toxicity↝, 11,   toxicity∅, 10,   Wound Healing↑, 4,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 17,   AntiFungal↓, 2,   AntiFungal↑, 7,   AntiP↓, 1,   AntiP↑, 4,   AntiViral↑, 13,   Bacteria↓, 28,   Diar↓, 3,   GutMicro↑, 15,   Sepsis↓, 2,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↑, 1,   Ingr↝, 6,  
Total Targets: 443

Scientific Paper Hit Count for: TumCCA, Tumor cell cycle arrest
41 Curcumin
31 Quercetin
30 Silver-NanoParticles
26 Sulforaphane (mainly Broccoli)
25 Thymoquinone
23 Apigenin (mainly Parsley)
22 Berberine
21 Fisetin
21 Kaempferol
18 Radiotherapy/Radiation
18 Magnolol
17 Phenethyl isothiocyanate
16 Baicalein
16 Emodin
15 Artemisinin
15 Capsaicin
15 Piperlongumine
14 Magnetic Fields
14 Luteolin
14 Shikonin
13 Cisplatin
13 doxorubicin
13 EGCG (Epigallocatechin Gallate)
13 Chrysin
13 Garcinol
13 Lycopene
13 Resveratrol
12 Ashwagandha(Withaferin A)
12 Betulinic acid
12 Eugenol
12 Cucurbitacin
12 Honokiol
12 Licorice
11 Graviola
11 Licochalcone A
11 Linalool
10 Propolis -bee glue
9 5-fluorouracil
9 Rosmarinic acid
9 Ellagic acid
9 Formononetin
9 phytic acid, Inositol hexakisphosphate
9 Ivermectin
9 mebendazole
9 Silymarin (Milk Thistle) silibinin
9 Urolithin
8 Allicin (mainly Garlic)
8 Carvacrol
8 Crocetin
8 Diindolylmethane
8 Indole-3-carbinol
8 Ferulic acid
8 Paclitaxel/Taxol
8 Gallic acid
8 Ginkgetin
8 HydroxyTyrosol
7 Chemotherapy
7 Melatonin
7 chitosan
7 Evodiamine
7 Fucoidan
7 Juglone
7 Phenylbutyrate
7 Pterostilbene
6 Astaxanthin
6 Berbamine
6 Boswellia (frankincense)
6 Celastrol
6 chaetocin
6 Gambogic Acid
6 itraconazole
6 Matrine
6 Morin
6 Naringin
6 Selenite (Sodium)
5 Coenzyme Q10
5 Beta-Caryophyllene
5 Bufalin/Huachansu
5 Boron
5 Caffeic Acid Phenethyl Ester (CAPE)
5 Centella asiatica / Gotu kola → asiaticoside
5 Chlorogenic acid
5 Carvone
5 Cynaropicrin
5 Dandelion Root
5 Eurycomanone
5 Fenbendazole
5 Genistein (soy isoflavone)
5 isoorientin
5 Laetrile B17 Amygdalin
5 lambertianic acid
5 methylseleninic acid
5 Methylsulfonylmethane
5 Nimbolide
5 Plumbagin
5 salinomycin
5 Ursolic acid
5 Vitamin K2
4 1,8-Cineole
4 Vitamin C (Ascorbic Acid)
4 D-limonene
4 Brucea javanica
4 Caffeic acid
4 Thymol-Thymus vulgaris
4 Selenium
4 Cinnamon
4 Hydroxycinnamic-acid
4 Deguelin
4 Hyperoside
4 Lemongrass Extract/Citral
4 Methyl Jasmonate
4 Magnetic Field Rotating
4 Moringa oleifera
4 Marjoram (Origanum majorana)
4 VitK3,menadione
4 α-Santalol/Sandalwood oil
4 Selenium NanoParticles
4 Aflavin-3,3′-digallate
3 Astragalus
3 Copper and Cu NanoParticles
3 Alpha-Lipoic-Acid
3 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
3 Andrographis
3 Gemcitabine (Gemzar)
3 Anethole/trans-Anethole
3 Fennel Oil/Foeniculum vulgare
3 Isovitexin
3 Biochanin A
3 borneol
3 Bruteridin(bergamot juice)
3 Carnosic acid
3 Celecoxib
3 Cynara scolymus/Globe Artichoke/Artichoke Extract
3 Date Fruit Extract
3 diet Methionine-Restricted Diet
3 Piperine
3 Flaxseed/Linseed
3 SDG/lignans
3 Ginger/6-Shogaol/Gingerol
3 Hibiscus sabdariffa
3 Hyperthermia
3 Inositol
3 Isoliquiritigenin
3 Lasiodin
3 Metformin
3 Magnesium
3 Propyl gallate
3 Parthenolide
2 Gold NanoParticles
2 Photodynamic Therapy
2 Glucose
2 tamoxifen
2 DTS(dibenzyl trisulphide) from Anamu
2 Ascorbyl Palmitate
2 Atorvastatin
2 beta-glucans
2 Baicalin
2 Bacopa monnieri
2 α-Bisabolol / Chamomile oil
2 Butyrate
2 Zinc
2 NTP, Non-Thermal Plasma,Cold Atmospheric Plasma
2 Chlorophyllin
2 Docetaxel
2 Dihydrocaffeic Acid
2 Cyclopamine
2 Dichloroacetate
2 Diclofenac
2 Echinacea
2 Electrical Pulses
2 Flaxseed Oil
2 carboplatin
2 Geraniol
2 isoflavones
2 isoquercitrin
2 Vitexin
2 Lactoferrin/Talactoferrin
2 Lutein
2 Methylene blue
2 Modified Citrus Pectin
2 Lemon Balm/Melissa officinalis
2 Mucuna pruriens/Velvet Bean
2 Mistletoe/Viscum album Extracts
2 Mushroom Chaga, Inonotus obliquus
2 Mushroom Lion’s Mane, Hericium erinaceus
2 Oleuropein
2 Rauwolfia serpentina/Indian Snakeroot
2 Rutin
2 Terpinen-4-ol / Tea Tree Oil
1 3-bromopyruvate
1 Ajoene (compound of Garlic)
1 alpha Linolenic acid
1 Arctigenin
1 Aloe anthraquinones
1 immunotherapy
1 epirubicin
1 brusatol
1 Bromelain
1 Carnosine
1 Selenate
1 Chocolate
1 Vitamin E
1 Polyphenols
1 Docosahexaenoic Acid
1 diet FMD Fasting Mimicking Diet
1 Dipyridamole
1 Disulfiram
1 Cannabichromene
1 Citric Acid
1 Sorafenib (brand name Nexavar)
1 flavonoids
1 Arsenic trioxide
1 Vitamin A, Retinoic Acid
1 Shilajit/Fulvic Acid
1 Galloflavin
1 Ginkgolic acids
1 Ginkgo biloba
1 Germanium inorganic
1 Ginkgolide B
1 Ginseng
1 HydroxyCitric Acid
1 Rapamycin
1 High-Ozonide Oil
1 Isobavachalcone
1 iodine
1 Inulin Prebiotic
1 Recombinant Methioninase
1 Lactobacillus
1 Lapachol
1 low dose naltrexone
1 Mung Bean Sprouts
1 Dordaviprone; Modeyso
1 MCT, metronomic chemo
1 Methylglyoxal
1 Myricetin
1 Niclosamide (Niclocide)
1 Proanthocyanidins
1 Purple Corn / Purple Maize
1 Sanguinarine
1 Psoralidin
1 Rhein
1 buckwheat sprouts
1 Oxaliplatin
1 Sulfasalazine
1 Auranofin
1 Salvia miltiorrhiza
1 Spermidine
1 Osimertinib
1 Adagrasib
1 Turmerones
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:322  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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