TumCP Cancer Research Results

TumCP, Tumor Cell proliferation: Click to Expand ⟱
Source:
Type:
Tumor cell proliferation is a key characteristic of cancer. It refers to the rapid and uncontrolled growth of cells that can lead to the formation of tumors.
Scientific Papers found: Click to Expand⟱
8014- itraC,    Itraconazole inhibits angiogenesis and tumor growth in non-small cell lung cancer
- vitro+vivo, NSCLC, NA
TumCP↓, TumCMig↓, ChemoSen↑, angioG↓, Hif1a↑,
8038- IVM,    Ivermectin and gemcitabine combination treatment induces apoptosis of pancreatic cancer cells via mitochondrial dysfunction
- in-vitro, PC, NA
*AntiP↑, AntiTum↑, ChemoSen↑, TumCP↓, TumCCA↑, cycD1/CCND1↓, mTOR↓, STAT3↑, Apoptosis↑, mtDam↑, ROS↑, MMP↓, OCR↓, MitoP↓,
8029- IVM,    Ivermectin in Cancer Treatment: Should Healthcare Providers Caution or Explore Its Therapeutic Potential?
- Review, Var, NA
TumCP↓, Apoptosis↑, Wnt↓, β-catenin/ZEB1↓, Akt↓, mTOR↓, BBB∅, ROS↑, MMP↓, Casp3↓, Casp9↑, TumCCA↑, P53↑, cMyc↓, MMP9↓, HSP27↓, ICD↑, Synergy↑, *AntiP↑,
8028- IVM,    Ivermectin as an Alternative Anticancer Agent: A Review of Its Chemical Properties and Therapeutic Potential
- Review, Var, NA
*BioAv↝, Apoptosis↑, TumCP↓, Wnt↓, β-catenin/ZEB1↓, TumCG↓, TumMeta↓, PI3K↓, Akt↓, mTOR↓, TumPF↓, CSCs↓, eff↑, ChemoSen↑, mtDam↑, MMP↓, ATP↓, ROS↑, NF-kB↓, BAX↑, Casp3↑, Casp9↑, ICD↑, Ki-67↓, PSA↓, YAP/TEAD↓,
8025- IVM,    Ivermectin has New Application in Inhibiting Colorectal Cancer Cell Growth
- in-vitro, CRC, SW480 - in-vivo, CRC, HCT116
*AntiP↓, *Inflam↓, *AntiViral↑, AntiTum↑, TumCP↓, Apoptosis↑, Casp3↑, Casp7↑, BAX↑, cl‑PARP↑, Bcl-2↓, mt-ROS↑, eff↓, Dose↝, TumCCA↑,
8024- IVM,    Ivermectin induces apoptosis of esophageal squamous cell carcinoma via mitochondrial pathway
- vitro+vivo, ESCC, KYSE-30 - in-vitro, ESCC, NE3
TumCP↓, mtDam↑, Apoptosis↑, ROS↑, NF-kB↓, Bax:Bcl2↑, LDH↝, TumCCA↑, cl‑Casp9↑, cl‑Casp3↑, cl‑PARP↑, eff↓,
8022- IVM,    Antibiotic ivermectin preferentially targets renal cancer through inducing mitochondrial dysfunction and oxidative damage
- vitro+vivo, RCC, NA
AntiP↑, TumCP↓, Apoptosis↑, selectivity↑, TumCG↓, MMP↓, mitResp↓, ATP↓, ROS↑, eff↓,
8040- IVM,    Ivermectin, a potential anticancer drug derived from an antiparasitic drug
- Review, Var, NA
Akt↓, mTOR↓, TumAuto↑, TumCP↓, TumCCA↑, Wnt↓, YAP/TEAD↓, MMP↓, mitResp↓, ATP↓, eff↓, eff↑, ROS↑, ChemoSen↑, PAK1↓, MAPK↓, EMT↓, Beclin-1/ATG6↑, ATG5↑, CSCs↓, STAT3↝, P-gp/ABCB1↓, MDR1↓, HSP27↓, Chl↑, TFE3↑,
8052- IVM,  rMETase,    Selective Synergy of Ivermectin Combined With Recombinant Methioninase Against Colon-Cancer Cells in Contrast to Normal Fibroblasts
- in-vitro, CRC, HCT116 - in-vitro, Nor, Hs27
Dose↝, TumCP↓, selectivity↑,
1167- IVM,    The river blindness drug Ivermectin and related macrocyclic lactones inhibit WNT-TCF pathway responses in human cancer
- vitro+vivo, Var, NA
Wnt↓, TCF↓, TumCP↓, Apoptosis↑, β-catenin/ZEB1↓, cycD1/CCND1↓,
7892- IVT,    Isovitexin attenuates tumor growth in human colon cancer cells through the modulation of apoptosis and epithelial-mesenchymal transition via PI3K/Akt/mTOR signaling pathway
- in-vitro, Nor, HCEC 1CT - in-vivo, Colon, NA
TumCP↓, selectivity↑, TumCMig↓, TumCI↓, EMT↓, Apoptosis↑, p‑PI3K↓, p‑Akt↓, p‑mTOR↓, Bcl-2↓, BAX↑, Casp3↑, TumVol↓, TumW↓,
8006- JG,  VitC,    Juglone-ascorbate treatment enhances reactive oxygen species mediated mitochondrial apoptosis in pancreatic cancer
- in-vitro, PC, PANC1 - in-vitro, PC, Bxpc-3
TumCP↓, ROS↑, antiOx⇅, Bcl-2↓, survivin↓, BAX↑, Trx2↓, Synergy↑,
7963- JG,    Pin1 Inhibitor Juglone Exerts Anti-Oncogenic Effects on LNCaP and DU145 Cells despite the Patterns of Gene Regulation by Pin1 Differing between These Cell Lines
- vitro+vivo, Pca, LNCaP - in-vitro, Pca, DU145
Pin1↓, TumCP↓, TumVol↓, other↝,
8002- JG,    Identification and Biological Evaluation of Juglone-Derived STAT3 Inhibitors against Colorectal Cancer
- in-vitro, PC, NA - in-vitro, CRC, NA
eff↑, STAT3↓, TumCP↓, selectivity↑,
8003- JG,  doxoR,    A juglone derivative that disrupts mitochondrial redox metabolism, inhibiting the breast fibroblast-cancer cell pro-migratory signaling induced by doxorubicin
- in-vitro, BC, NA
TumCP↓, TumCCA↑, mt-NADH↑, mt-OCR↑, mt-SOD2↑,
8004- JG,    TP53 Is a Potential Target of Juglone Against Colorectal Cancer: Based on a Combination of Molecular Docking, Molecular Dynamics Simulation, and In Vitro Experiments
- in-vitro, CRC, NA
*Inflam↓, *AntiViral↑, *AntiCan↑, ROS↑, P53↑, TumCP↓,
8007- JG,    Juglone reduces growth and migration of U251 glioblastoma cells and disrupts angiogenesis
- in-vitro, GBM, U251
Pin1↓, AntiCan↑, TumCP↓, Apoptosis↑, Casp3↑, TumCMig↓, angioG↓, VEGF↓, CD31/PECAM-1↓, TGF-β1↓,
974- JG,    Juglone down-regulates the Akt-HIF-1α and VEGF signaling pathways and inhibits angiogenesis in MIA Paca-2 pancreatic cancer in vitro
- in-vitro, PC, MIA PaCa-2
Hif1a↓, VEGF↓, p‑Akt↓, TumCP↓, TumCI↓,
5117- JG,    https://pubmed.ncbi.nlm.nih.gov/31283929/
- vitro+vivo, Liver, NA
TumCG↓, TumCP↓, Apoptosis↑, TumAuto↑, AMPK↑, mTOR↑, P53↑, H2O2↑, ROS↑,
1922- JG,    Juglone induces apoptosis of tumor stem-like cells through ROS-p38 pathway in glioblastoma
- in-vitro, GBM, U87MG
tumCV↓, TumCP↓, ROS↑, p‑p38↑, eff↓, Apoptosis↑, OS↑,
1918- JG,    ROS -mediated p53 activation by juglone enhances apoptosis and autophagy in vivo and in vitro
- in-vitro, Liver, HepG2 - in-vivo, NA, NA
TumCG↓, TumCP↓, Apoptosis↑, TumAuto↑, AMPK↑, mTOR↑, P53↑, H2O2↑, ROS↑, toxicity↝, p62↓, DR5↑, Casp8↑, PARP↑, cl‑Casp3↑,
1923- JG,    Mechanism of Juglone-Induced Cell Cycle Arrest and Apoptosis in Ishikawa Human Endometrial Cancer Cells
- in-vitro, Endo, NA
TumCP↓, TumCCA↑, cycA1/CCNA1↓, ROS↑, P21↑, CDK2↓, CDK1↓, CDC25↓, Bcl-2↓, Bcl-xL↓, BAX↑, BAD↑, Cyt‑c↑,
8087- KAE,    Therapeutic Importance of Kaempferol in the Treatment of Cancer through the Modulation of Cell Signalling Pathways
- Review, Var, NA
TumCCA↓, ROS↝, Apoptosis↑, TumCP↑, TumMeta↓, angioG↓, PI3K↓, EMT↓, Snail↓, E-cadherin↓, N-cadherin↓, MMP2↓, Casp9↑, Casp7↑, PARP↑, Apoptosis↑, *ROS↓, Hif1a↓, p‑Akt↓, P53↑, cMyc↓, Glycolysis↓, PKM2↓, miR-339-5p↝, BioAv↓,
8091- KAE,    Kaempferol sensitizes cell proliferation inhibition in oxaliplatin-resistant colon cancer cells
- in-vitro, CRC, HCT116 - in-vitro, CRC, HT-29
TumCP↓, AP-1↓, ChemoSen↑,
8092- KAE,    Kaempferol Reverses Aerobic Glycolysis via miR-339-5p-Mediated PKM Alternative Splicing in Colon Cancer Cells
- in-vitro, Colon, HCT116 - in-vitro, Colon, DLD1
TumCP↓, TumCCA↑, Apoptosis↑, GlucoseCon↓, lactateProd↓, ATP↓, miR-339-5p↑, Glycolysis↓, PKM2↓, PKM1↑,
8096- KAE,  5-FU,    Synergistic effect of kaempferol and 5‑fluorouracil on the growth of colorectal cancer cells by regulating the PI3K/Akt signaling pathway
- in-vitro, CRC, HCT8 - in-vitro, CRC, HCT8
ChemoSen↑, TumCP↓, Apoptosis↓, BAX↑, Bcl-2↓, TS↓, PI3K↓, Akt↓,
8099- KAE,  LT,  CHr,    Kaempherol and Luteolin Decrease Claudin-2 Expression Mediated by Inhibition of STAT3 in Lung Adenocarcinoma A549 Cells
- in-vitro, Lung, A549
CLDN2↓, TumCP↓, STAT3↓,
8101- KAE,    Kaempferol inhibits cell proliferation and glycolysis in esophagus squamous cell carcinoma via targeting EGFR signaling pathway
- vitro+vivo, ESCC, KYSE150 - vitro+vivo, ESCC, Eca109
TumCCA↑, TumCP↓, Glycolysis↓, HK2↓, GlucoseCon↓, lactateProd↓, EGFR↓, TumCG↓, P21↑, Dose↝, Ki-67↓,
8102- KAE,    Kaempferol inhibits gastric cancer tumor growth: An in vitro and in vivo study
- vitro+vivo, GC, MKN-28 - vitro+vivo, GC, SGC-7901 - in-vitro, GC, GES-1
TumCP↓, TumCCA↑, Apoptosis↑, selectivity↑, TumVol↓, CycB/CCNB1↓, CDK1↓, CDC25↓, Bcl-2↓, BAX↑, Casp3↑, Casp9↑, cl‑PARP↑, p‑Akt↓, p‑ERK↓, COX2/PTGS2↓,
8107- KAE,    Kaempferol Induces Cell Death in A2780 Ovarian Cancer Cells and Increases Their Sensitivity to Cisplatin by Activation of Cytotoxic Endoplasmic Reticulum-Mediated Autophagy and Inhibition of Protein Kinase B
- in-vitro, Ovarian, A2780S
Apoptosis↑, tumCV↓, TumCP↓, TumAuto↑, GRP78/BiP↑, PERK↑, ATF6↑, IRE1↑, LC3II↑, Beclin-1/ATG6↑, Ca+2↑, ChemoSen↑, ER Stress↑,
8061- KAE,    Kaempferol induces apoptosis in ovarian cancer cells through activating p53 in the intrinsic pathway
- in-vitro, Ovarian, A2780S - in-vitro, Ovarian, OVCAR-3
TumCP↓, Apoptosis↑, Casp3↑, Casp7↑, Risk↓, VEGF↓, TumCP↓, Dose↝, P53↑,
8065- KAE,    Kaempferol, a new nutrition-derived pan-inhibitor of human histone deacetylases
- in-vitro, Liver, HepG2 - in-vitro, CRC, HCT116
HDAC↓, tumCV↓, TumCP↓, selectivity↑, ac‑H3↝,
8067- KAE,  Cisplatin,    Kaempferol Induces Cell Death and Sensitizes Human Head and Neck Squamous Cell Carcinoma Cell Lines to Cisplatin
- in-vitro, HNSCC, NA
AntiCan↑, OCR↓, i-ATP↓, TumCMig↓, TumCP↓, Apoptosis↑, ChemoSen↑,
8072- KAE,    Natural defense against colorectal cancer: the effects of kaempferol on epigenetics, apoptosis, inflammation, oxidative stress, and cell proliferation
- Review, CRC, NA
AntiCan↑, TumCP↓, TumCI↓, Inflam↓, angioG↓, ROS↑, Apoptosis↑, ChemoSen↑, Risk↓, *antiOx↑, *Inflam↓, *AntiBio↑, *cardioP↑, *neuroP↑, selectivity↑, PUMA↑, Cyt‑c↑, cl‑Casp3↑, cl‑PARP↑, Apoptosis↑, NF-kB↓, COX2/PTGS2↓, CC(CDKs/cyclins)↓, TumCCA↑, BioAv↓, Synergy↑, DR4↑, DR5↑, Casp3↑, Casp9↑, Casp7↑, TumCP↓, TumCI↓, TumAuto↑, mtDam↑, P53↑, MAPK↑, *lipid-P↓, *TAC↑, *Catalase↑, *SOD↑, *GPx↑, *NRF2↑,
8075- KAE,  QC,    Systematic review on anticancer potential of Kaempferol and quercetin against lung, breast, and colorectal cancers with emphasis on in vitro and in vivo studies
- Review, Var, NA
tumCV↓, Apoptosis↑, TumCP↓, TumCMig↓, PI3K↓, Akt↓, MAPK↓, NF-kB↓, P53↑, Bcl-2↓, PARP↑, ERK↓, IQGAP3↓, γH2AX↑, cl‑Casp3↑, cl‑Casp9↑, Rho↓, Rac1↓, MMP2↓, MMP9↓, CTSB↓, CTSD↓, O-Glc↓, SERPINH1/HSP47↓, EMT↓, angioG↓, EGF↓, VEGFR2/KDR/Flk1↓, RadioS↑,
8076- KAE,    Kaempferol suppresses prostate cancer metastasis and tumor angiogenesis via disrupting the LIMK1/Cofilin pathway
- in-vivo, Pca, NA
AntiTum↑, TumCP↓, TumCCA↑, VEGF↓, CDK4↓, CDK6↓, LIMK1↓, Cofilin↓, angioG↓,
8077- KAE,    Kaempferol exerts anti-colorectal cancer effects through its multi-target mediated glucose metabolism remodeling
- in-vitro, CRC, NA
AntiTum↑, Glycolysis↓, PPP↓, OXPHOS↑, ROS↑, MMP↓, Apoptosis↑, TKT↓, ALDOA↓, TumCP↓,
8078- KAE,    Kaempferol induces mitophagy and disrupts iron metabolism via SFXN2 leading to apoptosis in multiple myeloma cells
- in-vitro, Mye, NA
TumCP↓, Apoptosis↑, mtDam↑, mt-TumAuto↑, i-Iron↑, SFXN2↓,
8079- KAE,    Endoplasmic Reticulum Stress-Mediated Apoptosis Induced by Kaempferol in Colorectal Cancer Cells
- in-vitro, CRC, DLD1 - in-vitro, Lung, A549 - in-vitro, Liver, HUH7 - in-vitro, Cerv, HeLa
*antiOx↑, *AntiBio↑, *AntiDiabetic↑, *AntiCan↑, Dose↝, TumCP↓, ER Stress↑, Apoptosis↑, Bcl-2↓, BAX↑, Casp3↑, Casp9↑, Casp12↝, NF-kB↓, P53↑,
9008- L-THE,    Theanine and cancer: A systematic review of the literature
- Review, Var, NA
EGFR↓, VEGFR1↓, MET↓, Akt↓, mTOR↓, JAK2↓, STAT3↓, TumMeta↓, TumCMig↓, TumCI↓, TumCP↓,
8115- LA,    Inhibitory Effect of Vaginal Lactobacillus Supernatants on Cervical Cancer Cells
- in-vitro, Cerv, CaSki
TumCP↓, TumCCA↑, E6↓, E7↓, CDK2↓, cycA1/CCNA1↓, P21↑,
863- Lae,    Amygdalin inhibits the growth of renal cell carcinoma cells in vitro
- in-vitro, RCC, NA
TumCG↓, TumCP↓, TumCCA↑, CDK1↓, CycB/CCNB1↓, E-cadherin↝, N-cadherin↝,
8147- Lae,    Mechanisms underlying the therapeutic effects of Amygdalin in treating Cervical Cancer based on multi-omics analysis
- in-vitro, Cerv, Ca9-22 - in-vitro, Cerv, HeLa
TumCP↓, Apoptosis↑, TumCCA↑, HK2↓, CAIX/CA9↓,
8150- lamb,    Reactive oxygen species dependent phosphorylation of the liver kinase B1/AMP activated protein kinase/ acetyl-CoA carboxylase signaling is critically involved in apoptotic effect of lambertianic acid in hepatocellular carcinoma cells
- in-vitro, HCC, HepG2 - in-vitro, HCC, SK-HEP-1
lipidLev↓, TumCCA↑, cl‑Casp3↑, cl‑PARP↑, AMPK↑, Akt↓, mTOR↓, Bcl-2↓, Bcl-xL↓, COX2/PTGS2↓, ROS↑, eff↓, p‑STK11/LKB1↑, p‑ACC↑, *Obesity↓, *Stress↓, *antiAll↑, tumCV↓, selectivity↑, TumCP↓, *antiAll↑,
8156- lamb,    A review on chemistry, source and therapeutic potential of lambertianic acid
- Review, Var, NA
*Obesity↓, *AntiCan↑, *AMPK↑, *β-HEX↓, NA↑, TumCCA↑, AMPK↑, ACC↑, p‑Akt↓, FOXM1↓, CycB/CCNB1↓, XIAP↓, Bcl-2↓, p‑STAT3↓, p‑NF-kB↓, Bcl-xL↓, survivin↓, VEGF↓, COX2/PTGS2↓, cMyc↓, IL6↓, TNF-α↓, ROS↑, STK11/LKB1↑, cl‑Casp3↑, cl‑PARP↑, Synergy↑, AR↓, TumCP↓, p‑P53↓, P21↓, p27/CDKN1B↓, cycD1/CCND1↓, CDK4↓, PSA↓, STAT3↓, ac‑p65↓, *antiAll↑,
8162- LapC,    Lapachol inhibits glycolysis in cancer cells by targeting pyruvate kinase M2
- in-vitro, Melanoma, MEL526 - in-vitro, Melanoma, MEL697 - in-vitro, Melanoma, MEL103
Glycolysis↓, OCR↑, PKM2↓, ATP↓, TumCP↓, Apoptosis↑, OXPHOS↑, Dose↝,
8164- LapC,    Inhibitory effects of lapachol on rat C6 glioma in vitro and in vivo by targeting DNA topoisomerase I and topoisomerase II
- vitro+vivo, GBM, NA
TumCP↓, Apoptosis↑, DNAdam↑, TOP1↓, TOP2↓,
8248- LCA,    Licochalcone A Inhibits the Proliferation of Human Lung Cancer Cell Lines A549 and H460 by Inducing G2/M Cell Cycle Arrest and ER Stress
- in-vitro, NSCLC, A549 - in-vitro, Lung, H460
tumCV↓, TumCG↓, TumCCA↑, MDM2↓, CycB/CCNB1↓, cDC2↓, CDC25↓, Casp3↑, PARP↑, ER Stress↑, p‑eIF2α↑, ATF4↑, TumCP↓, selectivity↑, Bcl-xL↓, Bcl-2↓,
8244- LCA,    Licochalcone A from licorice root, an inhibitor of human hepatoma cell growth via induction of cell apoptosis and cell cycle arrest
- in-vitro, Liver, HepG2
TumCP↓, ROS↑, TumCCA↑, Apoptosis↑, survivin↓, CycB/CCNB1↓, CDK1↓, WEE1↑, P21↑, cycD1/CCND1↑, JNK↑, TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, DR5↑, Casp3↑, Casp8↑, Casp10↑, Fas↑, BAD↑, BAX↑, PUMA↑, PKCδ↓, P70S6K↓, Akt↓,
8243- LCA,    Licochalcone A Inhibits Cellular Motility by Suppressing E-cadherin and MAPK Signaling in Breast Cancer
- in-vitro, BC, MDA-MB-231
Inflam↓, AntiTum↑, TumAuto↑, Sp1/3/4↓, TumCMig↓, MAPK↓, Akt↓, cl‑Casp3↑, cl‑Casp9↑, Bcl-2↓, Cyt‑c↑, TumCP↓, ROS↑, Apoptosis↑, TumCMig↓, TumCI↓, MMP↓, γH2AX↑,

Showing Research Papers: 751 to 800 of 1302
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1302

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↓, 2,   NA↑, 4,   NA↝, 1,   NA?, 1,   NA∅, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↑, 2,   antiOx↓, 5,   antiOx↑, 25,   antiOx⇅, 2,   ARE↑, 1,   ARE/EpRE↑, 1,   Catalase↓, 9,   Catalase↑, 7,   DJ-1↓, 1,   ENOX2↑, 1,   Fenton↑, 4,   GCLC↑, 2,   GPx↓, 4,   GPx↑, 7,   GPx1↓, 1,   GPx4↓, 30,   GPx4↑, 2,   GSH↓, 60,   GSH↑, 12,   GSH/GSSG↓, 10,   GSR↓, 1,   GSR↑, 3,   GSSG↑, 1,   ox-GSSG↑, 1,   GSTs↓, 1,   GSTs↑, 5,   H2O2↓, 3,   H2O2↑, 8,   mt-H2O2↑, 1,   HO-1↓, 9,   HO-1↑, 22,   HO-2↓, 1,   Iron↓, 3,   Iron↑, 19,   i-Iron↑, 5,   c-Iron↑, 1,   Keap1↓, 1,   Keap1↑, 2,   lipid-P↓, 10,   lipid-P↑, 41,   lipid-P↝, 1,   MDA↓, 4,   MDA↑, 20,   i-MDA↑, 2,   MPO↓, 1,   NADH↓, 2,   mt-NADH↑, 1,   NQO1?, 1,   NQO1↓, 1,   NQO1↑, 6,   Nrf1↑, 1,   NRF2↓, 27,   NRF2↑, 33,   NRF2↝, 1,   Prx↓, 1,   Prx3↑, 1,   Prx6↑, 1,   PrxII↓, 2,   RNS↑, 1,   ROS?, 3,   ROS↓, 38,   ROS↑, 412,   ROS⇅, 9,   ROS↝, 6,   ROS∅, 1,   i-ROS↑, 2,   mt-ROS↓, 2,   mt-ROS↑, 15,   selenoP↓, 1,   SOD↓, 13,   SOD↑, 11,   SOD1↓, 4,   SOD1↑, 1,   SOD2↓, 4,   SOD2↑, 4,   mt-SOD2↑, 1,   TAC↓, 1,   TBARS↓, 1,   Thiols↓, 2,   i-Thiols↓, 1,   TKT↓, 1,   TKT↝, 1,   Trx↓, 3,   Trx↑, 1,   Trx1↓, 1,   Trx1↑, 1,   ox-Trx1↑, 1,   Trx2↓, 1,   TrxR↓, 9,   TrxR1↓, 5,   TrxR1↑, 1,   xCT/SLC7A11↓, 10,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1,   Ferritin↑, 1,   FPN↝, 1,   FTH1↓, 5,   IronCh↑, 4,   LIP↑, 1,   NCOA4↑, 2,   SFXN2↓, 1,   Tf↑, 2,   TfR1/CD71↓, 1,   TfR1/CD71↝, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↑, 2,   BCR-ABL↓, 1,   CDC2↓, 5,   CDC25↓, 15,   CDC25↝, 1,   compI↓, 6,   compII↓, 1,   compIII↓, 3,   compV↓, 1,   EGF↓, 4,   ETC↓, 6,   HSP60/HSPD1↓, 2,   Insulin↓, 3,   KIF2C↓, 1,   mitResp↓, 6,   mitResp↑, 1,   MKK7↓, 2,   Mortalin↓, 1,   mtDam?, 1,   mtDam↑, 40,   OCR↓, 13,   OCR↑, 7,   mt-OCR↑, 1,   OXPHOS↓, 6,   OXPHOS↑, 10,   mt-OXPHOS↑, 1,   PDH↓, 1,   PDH↑, 4,   PDH↝, 1,   PDH∅, 1,   PGC-1α↑, 2,   PHB↓, 1,   PINK1↑, 1,   SIRT3↓, 1,   SIRT3↑, 2,   VDAC1↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 4,   5-HETE↓, 1,   5LO↓, 3,   ACC↓, 4,   ACC↑, 3,   p‑ACC↑, 1,   ACLY↓, 3,   ACOX1↑, 1,   ACSL1↓, 1,   ACSL4↑, 6,   ALAT↓, 5,   ALAT↑, 1,   ALDOA↓, 2,   ALDOB↑, 1,   AMP↑, 3,   AMPK?, 1,   AMPK↓, 2,   AMPK↑, 42,   p‑AMPK↑, 6,   ATP↓, 47,   ATP↑, 3,   e-ATP↑, 1,   i-ATP↓, 1,   i-ATP↑, 1,   mt-ATP↓, 1,   CAIX/CA9↓, 5,   CAIX/CA9↑, 1,   CBS↑, 1,   CPT1A↓, 1,   CPT1A↑, 1,   DGAT1↓, 1,   ECAR↓, 8,   ECAR↑, 1,   ECAR↝, 1,   ENO1↓, 3,   ENO3↑, 1,   FABP4↓, 1,   FAO↓, 1,   FASN↓, 12,   FASN↑, 1,   FBI-1↓, 1,   FBP1↑, 1,   FBPase↑, 1,   FDG↓, 1,   G6PD↓, 2,   GALNT10↓, 1,   GLO-I↓, 1,   GLS↓, 3,   glucoNG↓, 1,   glucoNG↑, 1,   glucose↓, 6,   GlucoseCon↓, 34,   glut↓, 1,   GlutaM↓, 1,   GlutMet↓, 3,   Glycolysis↓, 84,   Glycolysis↑, 1,   Glycolysis↝, 1,   GPI↓, 1,   GSK‐3β↓, 13,   GSK‐3β↑, 9,   p‑GSK‐3β↓, 7,   H2S↑, 1,   ac‑Histones↑, 1,   HK1↓, 2,   HK2↓, 39,   HK3↑, 1,   HMG-CoA↓, 6,   HSD17B4↓, 1,   IDH1↓, 1,   lactateProd↓, 40,   lactateProd↑, 1,   LDHA↓, 19,   LDHA∅, 1,   LDL↓, 4,   LDL↑, 1,   lipidLev↓, 2,   lipoGen↓, 2,   MCT4↓, 1,   NAD↓, 1,   NADPH↓, 6,   O-Glc↓, 1,   PCK1↑, 1,   PDK1 / PDPK1?, 2,   PDK1 / PDPK1↓, 15,   p‑PDK1 / PDPK1↓, 1,   PDKs↓, 1,   PFK↓, 10,   PFK1↓, 6,   PFK2↓, 1,   PFKFB3↓, 2,   PFKFB4?, 1,   PGC1A↑, 1,   PGK1↓, 2,   PGK2↑, 1,   PGM1↓, 1,   PGM1↑, 1,   PGM3↑, 1,   PIP3↑, 1,   PKLR↑, 1,   PKM1↑, 1,   PKM2↓, 37,   PKM2↑, 1,   PKM2∅, 2,   p‑PKM2↓, 1,   polyA↓, 1,   PPP↓, 3,   PYGL↓, 1,   Pyrim↓, 1,   R5P↝, 1,   p‑S6↓, 2,   SCD1↓, 4,   SCP2↓, 1,   SIRT1↓, 8,   SIRT1↑, 10,   SIRT2↓, 1,   SIRT2↑, 1,   SREBF2↓, 1,   SREBP1/SREBF1↓, 6,   SREBP2↓, 2,   TCA↓, 2,   TCA↑, 2,   TPI↓, 1,   TS↓, 3,   TumCM/A↓, 1,   UGDH↓, 2,   Warburg↓, 25,  

Cell Death(tgid=5) ⓘ

AIF↑, 12,   APAF1↑, 9,   Apoptosis?, 6,   Apoptosis↓, 20,   Apoptosis↑, 647,   mt-Apoptosis↑, 4,   ASC↑, 1,   BAD?, 1,   BAD↓, 3,   BAD↑, 19,   p‑BAD↓, 1,   Bak↑, 10,   BAX↓, 6,   BAX↑, 210,   BAX⇅, 1,   BAX↝, 1,   Bax:Bcl2↑, 41,   Bcl-2↓, 223,   Bcl-2↑, 6,   Bcl-2↝, 1,   cl‑Bcl-2↑, 1,   Bcl-xL↓, 46,   Bcl-xL↑, 2,   BID↓, 1,   BID↑, 6,   BIM↑, 7,   BNIP3↑, 2,   BOK↑, 1,   Casp↓, 3,   Casp↑, 53,   Casp↝, 2,   cl‑Casp↑, 3,   Casp1↑, 1,   cl‑Casp1↑, 1,   Casp10↑, 2,   Casp10∅, 1,   Casp12↑, 3,   Casp12↝, 1,   cl‑Casp12↑, 2,   cl‑Casp12↝, 1,   Casp2↑, 3,   Casp3↓, 7,   Casp3↑, 205,   Casp3↝, 2,   cl‑Casp3↓, 1,   cl‑Casp3↑, 84,   proCasp3↓, 1,   proCasp3↑, 3,   CASP4↑, 1,   Casp6↑, 1,   Casp7↓, 1,   Casp7↑, 27,   cl‑Casp7↑, 4,   Casp8↓, 1,   Casp8↑, 44,   Casp8∅, 1,   cl‑Casp8↑, 9,   proCasp8↓, 1,   proCasp8↑, 3,   Casp9↑, 106,   p‑Casp9↑, 1,   cl‑Casp9↓, 1,   cl‑Casp9↑, 22,   proCasp9↓, 1,   proCasp9↑, 2,   cFLIP↓, 1,   Cupro↑, 1,   Cyt‑c↑, 104,   Cyt‑c↝, 3,   mt-Cyt‑c↓, 1,   Diablo↑, 5,   DIDO1/DIO-1↑, 1,   DR5↑, 21,   DR5∅, 1,   Endon↑, 4,   FADD↑, 8,   FADD∅, 1,   Fas↓, 2,   Fas↑, 21,   FasL↓, 1,   FasL↑, 7,   FasL⇅, 1,   Ferroptosis↓, 2,   Ferroptosis↑, 47,   GranB/GZMB↑, 1,   GRP58↓, 1,   GSDMD↑, 2,   cl‑GSDME↑, 1,   HEY1↓, 1,   IAP1↓, 11,   IAP1↑, 1,   IAP2/BIRC3↓, 2,   ICAD↓, 1,   ICAD↑, 1,   ICD↑, 2,   iNOS↓, 16,   Mcl-1↓, 29,   MDM2↓, 15,   p‑MDM2↓, 1,   MLKL↑, 1,   MOMP↑, 2,   NAIP↓, 1,   Necroptosis↑, 8,   necrosis↑, 4,   NOXA↑, 4,   p38↓, 4,   p38↑, 26,   p‑p38↓, 4,   p‑p38↑, 8,   Paraptosis↑, 1,   Perforin↑, 1,   PUMA↓, 1,   PUMA↑, 7,   Pyro↑, 4,   RIP3↓, 1,   RIP3↑, 2,   p‑RIP3↑, 1,   survivin↓, 72,   TNFR 1↓, 1,   TNFR 1↑, 2,   TRAIL↑, 3,   TRAIL⇅, 1,   TRAILR↑, 3,   TumCD?, 1,   TumCD↓, 2,   TumCD↑, 36,   TumCD∅, 2,   TUNEL↑, 2,   XIAP↓, 31,   YAP/TEAD↓, 12,   YAP/TEAD↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt?, 1,   Akt↓, 239,   Akt↑, 9,   Akt↝, 1,   p‑Akt↓, 85,   p‑Akt↑, 2,   AKT1↓, 7,   Akt2↓, 3,   AKT3↓, 1,   AMPKα↓, 1,   AMPKα↑, 1,   BCAP↓, 1,   BRAF↓, 1,   CaMKII ↓, 3,   Cavin3↓, 1,   CIP2A↓, 2,   CK2↓, 3,   cMET↓, 3,   p‑cMET↑, 1,   CREB↓, 2,   CREB2↓, 1,   cSrc↓, 3,   DDIT4↑, 1,   EGFR↓, 42,   p‑EGFR↓, 4,   ERK↓, 71,   ERK↑, 9,   ERK↝, 1,   p‑ERK↓, 28,   p‑ERK↑, 6,   FGFR1↓, 2,   FGFR2↓, 1,   FGFR4/CD334↓, 1,   FOXD3↑, 2,   HER2/EBBR2↓, 13,   p‑HER2/EBBR2↓, 1,   HGF/c-Met↓, 2,   Hippo↓, 1,   IGF-1R↓, 10,   IGF-2R↑, 1,   IGFR↓, 4,   IKKα↓, 10,   IKKα↑, 3,   p‑IKKα↓, 2,   ILK↓, 1,   IR↓, 2,   IκB↓, 1,   JAK↓, 11,   JAK1↓, 9,   JAK1↑, 1,   JAK2↓, 23,   p‑JAK2↓, 2,   JNK↓, 6,   JNK↑, 30,   JNK↝, 1,   p‑JNK↓, 1,   p‑JNK↑, 7,   cl‑JNK↑, 1,   LIMK1↓, 1,   MAP2K1/MEK1↓, 1,   p‑MAP2K1/MEK1↓, 1,   MAPK?, 1,   MAPK↓, 49,   MAPK↑, 23,   MAPK↝, 1,   p‑MAPK↓, 1,   p‑MAPK↑, 4,   MARK4↓, 2,   MEK↓, 7,   p‑MEK↓, 3,   p‑MEK↑, 1,   MKK4↓, 1,   mTOR?, 1,   mTOR↓, 124,   mTOR↑, 6,   mTOR⇅, 1,   p‑mTOR↓, 20,   mTORC2↓, 1,   mTORC2↑, 1,   p42↑, 1,   p70S6↓, 2,   p70S6↑, 1,   p‑p70S6↓, 1,   p‑p70S6↑, 1,   P70S6K↓, 7,   p‑P70S6K↓, 3,   p85S6K↓, 1,   P90RSK↓, 1,   p‑P90RSK↑, 1,   PDGFR-BB↓, 1,   PDGFRA↓, 1,   PDGFRB↓, 1,   PFKFB2↓, 1,   PHKG1↑, 1,   PI3K?, 1,   PI3K↓, 168,   PI3K↑, 3,   PI3K↝, 1,   p‑PI3K↓, 23,   PI3K/Akt↓, 6,   PI3k/Akt/mTOR↓, 1,   PI3K/mTOR/ETS2↓, 1,   PKA↓, 4,   PKCδ↓, 14,   PP2A↑, 1,   PRAS40↓, 1,   PRAS40↑, 1,   PRKCQ/PKCθ↓, 1,   PTEN↓, 3,   PTEN↑, 29,   Raf↓, 6,   e-Raf↓, 1,   c-Raf↓, 1,   RAS↓, 13,   RIP1↓, 2,   RIP1↑, 1,   S6K↓, 1,   p‑S6K↓, 1,   SGK1↓, 1,   SHP1↑, 3,   Sp1/3/4↓, 15,   Src↓, 3,   p‑Src↓, 2,   STAT↓, 8,   p‑STAT↓, 1,   STAT3↓, 94,   STAT3↑, 6,   STAT3↝, 1,   p‑STAT3↓, 23,   p‑STAT3↑, 2,   mt-STAT3↓, 1,   STAT4↓, 1,   STAT5↓, 3,   STAT6↓, 2,   STK11/LKB1↑, 1,   p‑STK11/LKB1↑, 1,   THEM4/CTMP↑, 1,   TSC2↑, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 1,   ATF2↓, 2,   ATF3↑, 2,   ATF4↑, 14,   p‑ATF4↝, 1,   BRD4↓, 1,   CBP↓, 2,   CBP↑, 1,   ChrMod↑, 1,   cJun↓, 5,   cJun↑, 2,   p‑cJun↓, 1,   p‑cJun↑, 2,   cMyc↓, 54,   cMyc↑, 2,   p‑cMyc↑, 1,   DNMT1↓, 6,   DNMT1↑, 1,   DNMT3A↓, 1,   DNMT3B↓, 2,   DNMTs↓, 7,   EZH2↓, 3,   FOXM1↓, 5,   FOXO↑, 2,   FOXO1↓, 3,   FOXO1↑, 4,   FOXO3↓, 2,   FOXO3↑, 4,   p‑FOXO3↓, 1,   FOXO4↓, 2,   FOXO4↑, 1,   GATA2↑, 1,   GATA3↓, 1,   H3↓, 2,   H3↑, 1,   p‑H3↑, 1,   ac‑H3↑, 3,   ac‑H3↝, 1,   H3K18↓, 1,   H3K27ac∅, 1,   H3K9↓, 2,   H4↑, 2,   ac‑H4↑, 1,   ac‑H4∅, 1,   HATs↓, 4,   HATs↑, 1,   HDAC↓, 25,   HDAC1↓, 6,   HDAC2↓, 3,   HDAC3↓, 3,   HDAC4↓, 1,   HDAC6↓, 2,   HDAC8↓, 1,   HES1↓, 3,   HMTs↓, 1,   HOXB-AS1↓, 1,   IGF2BP3/IMP3/KOC↓, 1,   JPT1/HN1↓, 1,   KISS1↑, 1,   LINC01116↓, 1,   miR-106b↓, 2,   miR-107↑, 2,   miR-10b-5p↓, 1,   miR-122-5p↑, 1,   miR-124-3p↓, 1,   miR-130a↓, 3,   miR-133a-3p↑, 1,   miR-139-5p↑, 2,   miR-143↑, 1,   miR-145↑, 1,   miR-148a↓, 1,   miR-149↑, 1,   miR-155↓, 3,   miR-182-5p↓, 1,   miR-192-5p↑, 1,   miR-19b↓, 2,   miR-205↑, 1,   miR-21↓, 12,   miR-21↝, 1,   miR-215-5p↑, 1,   miR-218↑, 1,   miR-22↑, 2,   miR-221↓, 1,   miR-224↓, 2,   miR-25-5p↓, 1,   miR-29b↑, 1,   miR-30a-5p↑, 1,   miR-320a↓, 1,   miR-339-5p↑, 1,   miR-339-5p↝, 1,   miR-340↓, 2,   miR-34a↑, 6,   miR-375↓, 1,   miR-375↑, 2,   miR-384↑, 1,   miR-422a↑, 2,   miR-486↑, 1,   miR-490↑, 1,   miR-590-3p↑, 1,   miR-592↑, 1,   miR-99↑, 1,   MTA2↓, 1,   Myc↓, 5,   Myc↑, 1,   MYCN↓, 1,   MYCN↑, 1,   n-MYC↓, 1,   NDRG1↑, 1,   NNMT↓, 1,   OCT4↓, 11,   OLIG2↓, 1,   other?, 1,   other↓, 5,   other↑, 12,   other↝, 38,   other∅, 1,   PAX2↓, 1,   PCAF↓, 1,   SD↑, 1,   SOX2↓, 10,   SOX4↓, 1,   SOX9↓, 1,   SUV39H↓, 5,   TBX15↑, 1,   TFAP2A↓, 1,   TFE3↑, 1,   TLE1↓, 1,   tumCV↓, 115,   tumCV↑, 4,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 5,   CHOP/DDIT3↓, 1,   CHOP/DDIT3↑, 26,   p‑CHOP/DDIT3↝, 1,   CRT↑, 1,   EDEM↑, 1,   eIF2α↓, 2,   eIF2α↑, 8,   p‑eIF2α↑, 5,   p‑eIF2α↝, 1,   ER Stress↓, 1,   ER Stress↑, 53,   Erlin1↑, 1,   GRP78/BiP↓, 1,   GRP78/BiP↑, 15,   GRP94↑, 1,   HSF1↓, 1,   HSP27↓, 3,   HSP27↑, 1,   HSP70/HSPA5↓, 5,   HSP70/HSPA5↑, 5,   e-HSP70/HSPA5↓, 1,   HSP90↓, 21,   HSP90↑, 2,   HTRA↓, 1,   IRE1↓, 1,   IRE1↑, 3,   IRE1∅, 1,   p‑IRE1↑, 1,   NQO2↑, 1,   OTUB2↓, 1,   PDI↑, 2,   PERK↑, 13,   p‑PERK↝, 1,   Proteasome↓, 3,   SERPINH1/HSP47↓, 1,   UPR↓, 1,   UPR↑, 10,   mt-UPR↑, 1,   XBP-1↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG13↑, 2,   ATG16L1↑, 1,   ATG3↓, 1,   ATG3↑, 3,   ATG5↓, 1,   ATG5↑, 10,   ATG7↑, 5,   autolysosome↑, 1,   Beclin-1/ATG6↓, 8,   Beclin-1/ATG6↑, 30,   CTSB↓, 2,   CTSD↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 7,   LC3B↓, 1,   LC3B↑, 3,   LC3B-II↓, 1,   LC3B-II↑, 7,   LC3I↓, 1,   LC3II↓, 2,   LC3II↑, 19,   LC3s↓, 1,   LC3s↑, 2,   lysoMP↑, 2,   MitoP↓, 1,   p62↓, 13,   p62↑, 7,   PARK2↑, 1,   RUBCN↓, 1,   SESN2↑, 2,   TumAuto?, 1,   TumAuto↓, 4,   TumAuto↑, 99,   TumAuto⇅, 1,   TumAuto↝, 2,   mt-TumAuto↑, 1,   ULK1/ATG1↑, 1,   p‑ULK1/ATG1↑, 1,   VMP-1↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

8-oxo-dG↑, 1,   ATM↓, 1,   ATM↑, 4,   p‑ATM↑, 1,   ATR↑, 4,   BRCA1↓, 3,   BRCA2↓, 1,   DNAdam↓, 5,   DNAdam↑, 95,   DNArepair↓, 5,   DNArepair↑, 3,   ERCC1↓, 2,   ERCC3↑, 1,   ERCC4/XPF↓, 1,   m-FAM72A↓, 1,   FEN1↓, 2,   hTERT/TERT↓, 13,   Ku70/XRCC6↓, 1,   NHEJ↓, 1,   NKX3.1↑, 1,   P53?, 2,   P53↓, 6,   P53↑, 128,   P53⇅, 1,   P53↝, 4,   p‑P53↓, 1,   p‑P53↑, 6,   p53 Wildtype↓, 1,   PARP↓, 3,   PARP↑, 24,   PARP↝, 2,   cl‑PARP↓, 1,   cl‑PARP↑, 111,   PARP1↑, 4,   cl‑PARP1↑, 3,   PCNA↓, 44,   PCNA↑, 1,   PCNA↝, 1,   POLD1↓, 1,   RAD51↓, 1,   SIRT6↓, 2,   SIRT6↑, 1,   SMG1↑, 1,   Telomerase↓, 13,   TOP1↓, 6,   TOP2↓, 6,   TOP2↑, 1,   TP53↓, 1,   TP53↑, 3,   TRF2↓, 2,   UHRF1↓, 1,   XRCC1↓, 1,   γH2AX↓, 1,   γH2AX↑, 17,   p‑γH2AX↑, 2,  

Cell Cycle & Senescence(tgid=11) ⓘ

AURKB↓, 1,   BRD4↓, 1,   CC(CDKs/cyclins)↓, 2,   CDK1↓, 27,   CDK1↑, 5,   CDK1↝, 1,   p‑CDK1↓, 1,   CDK1/2/5/9↓, 1,   CDK2↓, 53,   CDK2↑, 6,   CDK4↓, 61,   CDK4↑, 3,   CDK4∅, 1,   CDK4/6↓, 1,   CDK6↓, 19,   CDK6↑, 3,   CDK6∅, 1,   CDK7↓, 1,   CDK8↓, 2,   CDKN1C/p57↓, 1,   CDKN2C/p18↑, 1,   CHK1↓, 3,   CHK1↑, 4,   CHK1↝, 1,   p‑CHK1↓, 1,   p‑CHK1↑, 1,   Chk2↓, 3,   Chk2↑, 4,   p‑Chk2↑, 1,   Cyc↓, 4,   cycA1/CCNA1↓, 16,   cycA1/CCNA1↑, 2,   CycB/CCNB1↓, 40,   CycB/CCNB1↑, 6,   CycB/CCNB1↝, 1,   cycD1/CCND1↓, 144,   cycD1/CCND1↑, 4,   cycD1/CCND1↝, 1,   cycD1/CCND1∅, 1,   CycD3↓, 4,   cycE/CCNE↓, 33,   cycE/CCNE↑, 3,   cycE/CCNE↝, 1,   cycE1↓, 1,   E2F4↑, 1,   E2Fs↓, 7,   E2Fs↑, 1,   FBXO5/EMI1↓, 1,   GADD34↑, 1,   GADD45A↓, 1,   GADD45A↑, 5,   Ki-67↓, 65,   MAD↓, 1,   mitA↑, 4,   MKI67↑, 1,   p19↑, 1,   P21↓, 5,   P21↑, 113,   P21↝, 1,   p‑P21↑, 1,   p27/CDKN1B↓, 5,   p27/CDKN1B↑, 35,   cl‑p27/CDKN1B↓, 1,   PLK1↓, 1,   pRB↓, 4,   p‑pRB↓, 1,   RB1↓, 1,   RB1↑, 2,   p‑RB1↓, 2,   RRM2↓, 1,   TAp63α↑, 1,   TumCCA?, 3,   TumCCA↓, 13,   TumCCA↑, 418,   WEE1↑, 3,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

4E-BP1↓, 2,   ALDH↓, 5,   ALDH1A1↓, 4,   ALDH1A3↓, 1,   AXIN1↓, 1,   AXIN1↑, 3,   BMI1↓, 2,   BMP7/OP1↓, 2,   CD133↓, 15,   CD24↓, 6,   CD34↓, 2,   cFos↓, 7,   cMYB↓, 1,   CSCs?, 1,   CSCs↓, 62,   CSCs↑, 3,   CSCsMark↓, 1,   Diff↓, 1,   Diff↑, 11,   EIF4E↓, 1,   EP2↓, 1,   EP4/PTGER4↓, 2,   FGF↓, 3,   GH↓, 1,   Gli1↓, 14,   HH?, 1,   HH↓, 22,   HMGCR↓, 2,   IGF-1↓, 10,   IGF-1↑, 1,   IGF-2↓, 1,   IGF-2↑, 1,   IGFBP1↑, 1,   IGFBP3↑, 2,   JAG1↓, 1,   Jun↓, 2,   Ki-67↓, 65,   Let-7↑, 3,   LRP6↓, 2,   MCM2↓, 1,   mTORC1↓, 4,   Nanog↓, 11,   Nestin↓, 1,   NICD↓, 1,   NKD2↑, 2,   NOTCH↓, 14,   NOTCH↑, 2,   NOTCH1↓, 11,   NOTCH1↑, 1,   NOTCH1↝, 1,   NOTCH2↓, 1,   NOTCH3↓, 3,   OGF↑, 1,   OGFr↑, 4,   p300↓, 3,   PCLAF↓, 1,   Piezo1↑, 1,   circ‑PLEKHM3↑, 1,   PTCH1↓, 2,   SCF↓, 1,   Shh↓, 10,   Smo↓, 6,   Smo∅, 1,   TAZ↓, 2,   TumCG?, 3,   TumCG↓, 213,   TumCG↑, 7,   TumCG↝, 1,   TumCG∅, 1,   TumCP?, 6,   TumCP↓, 1259,   TumCP↑, 26,   TumCP⇅, 6,   TumCP∅, 5,   p‑TumCP↓, 1,   tyrosinase↓, 2,   WDR72↓, 1,   Wnt↓, 57,   Wnt/(β-catenin)↓, 9,   ZFX↓, 2,  

Migration(tgid=13) ⓘ

AEG1↓, 1,   AGRN↓, 1,   annexin II↓, 1,   AntiAg?, 1,   AntiAg↑, 1,   AP-1↓, 12,   AP-1↝, 1,   ASAP2↓, 1,   ATPase↓, 2,   AXL↓, 2,   BACH1↓, 1,   BACH1↑, 1,   Ca+2?, 1,   Ca+2↓, 3,   Ca+2↑, 36,   Ca+2↝, 2,   i-Ca+2↑, 3,   CAFs/TAFs↓, 1,   cal2↑, 2,   CCAT1↓, 2,   CCN2/CTGF↓, 3,   CD11b↑, 1,   CD38↓, 1,   CD38↑, 1,   Cdc42↓, 1,   Cdc42↑, 1,   Chl↑, 1,   Cofilin↓, 2,   COL1A1↓, 1,   COL3A1↓, 1,   COL4A3↓, 1,   E-cadherin↓, 10,   E-cadherin↑, 62,   E-cadherin↝, 1,   EMT?, 1,   EMT↓, 117,   EMT↑, 2,   EpCAM↓, 2,   F-actin↓, 3,   FAK↓, 13,   FAK↑, 2,   p‑FAK↓, 5,   Fibronectin↓, 5,   Furin↓, 1,   GLI2↓, 4,   GLI3↑, 1,   IQGAP3↓, 1,   ITGA5↓, 1,   ITGB1↓, 3,   ITGB4↓, 1,   ITGB6↓, 1,   KRAS↓, 1,   LAMs↓, 2,   LEF1↓, 1,   LIMK2↓, 1,   MALAT1↓, 2,   MET↓, 2,   MET↑, 1,   MMP-10↓, 2,   MMP1↓, 4,   MMP13↓, 4,   MMP14↓, 1,   MMP16↓, 2,   MMP17↓, 1,   MMP2↓, 102,   proMMP2↓, 1,   MMP3↓, 8,   MMP7↓, 7,   MMP9↓, 139,   MMP9↑, 2,   MMPs↓, 31,   MMPs↝, 1,   MTA1↓, 1,   MUC1↓, 1,   MUC4↓, 1,   N-cadherin↓, 42,   N-cadherin↑, 1,   N-cadherin↝, 1,   NCAM↓, 1,   NEDD9↓, 1,   p44↓, 1,   p44↑, 1,   p‑p44↓, 1,   PAK1↓, 3,   pax↓, 2,   PCBP1↓, 1,   PDGF↓, 6,   Rac1↓, 2,   RHBDD1↓, 1,   Rho↓, 5,   ROCK1↓, 3,   Sharpin↓, 1,   Slug↓, 16,   Smad1↓, 1,   Smad1↑, 1,   Smad1↝, 1,   SMAD2↓, 2,   p‑SMAD2↓, 5,   SMAD3↓, 5,   SMAD3↑, 1,   p‑SMAD3↓, 3,   SMAD4↓, 1,   p‑SMAD4↓, 1,   Snail?, 1,   Snail↓, 32,   Snail↑, 1,   SPARC↑, 2,   STAC2↓, 1,   talin?, 1,   talin↓, 1,   TET1↓, 1,   TET1↑, 3,   TGF-β↓, 21,   TGF-β↑, 2,   TGF-β↝, 1,   TGF-β1↓, 3,   THBS1↓, 1,   TIMP1↓, 2,   TIMP1↑, 14,   TIMP2↓, 1,   TIMP2↑, 11,   TIMP3↑, 1,   TRIB3↑, 1,   TSC1↑, 2,   TumCA↓, 6,   TumCA↑, 1,   TumCI↓, 258,   TumCI↑, 4,   TumCMig?, 1,   TumCMig↓, 293,   TumCMig↑, 6,   TumMeta↓, 139,   TumMeta↑, 9,   TumPF↓, 1,   Twist↓, 16,   Twist↑, 1,   TXNIP↑, 3,   uPA↓, 16,   uPAR↓, 3,   UroPA↓, 1,   Vim?, 1,   Vim↓, 52,   Vim↑, 2,   vinculin↓, 1,   Zeb1↓, 7,   ZEB2↓, 2,   ZEB2↑, 1,   α-SMA↓, 4,   α-SMA↑, 1,   α-tubulin↓, 2,   β-catenin/ZEB1↓, 77,   β-catenin/ZEB1↑, 2,   p‑β-catenin/ZEB1↑, 1,   cl‑β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 162,   angioG↑, 5,   CCN1/CYR61↓, 1,   CD31/PECAM-1↓, 4,   EGR1↓, 1,   EGR1↑, 1,   EGR4↓, 1,   Endoglin↑, 2,   eNOS↓, 3,   HIF-1↓, 6,   Hif1a↓, 84,   Hif1a↑, 2,   Hif1a↝, 1,   Hypoxia↓, 2,   LOX1↓, 1,   NO↓, 7,   NO↑, 5,   PGI2↓, 1,   TYMP/ECGF1↓, 1,   VCAM-1↓, 4,   VEGF↓, 120,   VEGF↑, 1,   VEGF↝, 1,   VEGFR1↓, 5,   VEGFR2/KDR/Flk1↓, 15,   p‑VEGFR2/KDR/Flk1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

ABCG1↓, 1,   AQPs↓, 2,   BBB↑, 6,   BBB∅, 1,   CellMemb↑, 3,   CLDN1↓, 1,   CLDN1↑, 1,   CLDN2↓, 2,   EPR↑, 9,   GLUT1↓, 25,   GLUT1↑, 2,   GLUT1∅, 1,   GLUT2↓, 3,   GLUT3↓, 2,   GLUT3↑, 1,   GLUT3∅, 1,   GLUT4↓, 1,   IBI↑, 1,   KCNH2/hERG↓, 1,   MMP↓, 173,   MMP↑, 4,   MMP↝, 2,   MMP∅, 1,   MPT↓, 1,   MPT↑, 4,   NHE1↓, 1,   OATPs↓, 1,   OCLN↑, 1,   SLC12A5↓, 1,   SVCT-2↓, 1,   TJ↑, 1,   TRPM7↓, 1,   TRPM7↑, 1,   TRPV1↑, 3,   TRPV1↝, 1,   VGCC↑, 2,   VGSC↑, 1,   ZO-1↓, 1,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

ANXA1↓, 1,   B2M↓, 1,   CB2 / CNR2↓, 1,   CB2 / CNR2↑, 3,   CD155↓, 2,   CD4+↓, 1,   CD4+↑, 5,   CD44↓, 19,   CD44↝, 1,   CD47↓, 1,   CD8+↑, 11,   cDC2↓, 1,   p‑cDC2↓, 1,   COX1↓, 3,   COX1↑, 1,   COX2/PTGS2↓, 85,   COX2/PTGS2↑, 2,   COX2/PTGS2↝, 1,   CXCL12↓, 2,   CXCL16↓, 1,   CXCL6/GCP-2↓, 1,   CXCL9↓, 1,   CXCR2↓, 2,   CXCR4↓, 14,   DCells↑, 1,   DR4↑, 11,   DR4∅, 1,   Eos↑, 1,   FOXP3↓, 1,   FOXP3↑, 1,   Gal-3↓, 3,   Gal1↑, 1,   HMGB1↓, 5,   HMGB1↑, 1,   ICAM-1↓, 9,   IFN-γ↓, 3,   IFN-γ↑, 3,   Igs↑, 2,   IL1↓, 3,   IL1↑, 2,   IL10↓, 2,   IL10↑, 2,   IL12↑, 3,   IL17↓, 1,   IL18↓, 2,   IL1α↓, 1,   IL1β↓, 22,   IL1β↑, 2,   IL2↓, 1,   IL2↑, 2,   IL4↓, 2,   IL4↑, 2,   IL5↓, 1,   IL6↓, 49,   IL6↑, 2,   IL8↓, 12,   IL8↑, 1,   Imm↑, 25,   Imm↝, 2,   Inflam↓, 65,   IRAK1↓, 1,   IRAK4↓, 1,   LIF↑, 1,   LRIG1↑, 1,   LTA/TNF-β↓, 1,   LTA/TNF-β↑, 1,   pol-M1↑, 2,   M2 MC↓, 4,   pol-M2 MC↓, 1,   MCP1/CCL2↓, 4,   MCT1↓, 2,   MIP2↓, 1,   mPGES-1↓, 1,   MyD88↑, 1,   Neut↑, 1,   NF-kB?, 1,   NF-kB↓, 204,   NF-kB↑, 7,   NF-kB↝, 2,   p‑NF-kB↓, 3,   p‑NF-kB↑, 2,   NFKBIZ/IκBζ↓, 1,   NK cell↑, 7,   NLRP3↓, 6,   NLRP3↑, 3,   NOD1↓, 1,   p50↓, 1,   p65↓, 9,   p65↑, 1,   p‑p65↓, 1,   ac‑p65↓, 1,   ac‑p65↑, 1,   PD-1↓, 3,   PD-L1↓, 10,   PD-L1↑, 3,   PGE2↓, 13,   PSA↓, 17,   SOCS-3↑, 1,   T-Cell↑, 4,   TCF↓, 5,   Th1 response↑, 2,   TIGIT↓, 1,   TLR1↑, 1,   TLR2↑, 1,   TLR4↓, 6,   TLR4↑, 2,   TNF-α↓, 42,   TNF-α↑, 8,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 3,   TRADD↑, 1,   Treg lymp↓, 2,  

Cellular Microenvironment(tgid=17) ⓘ

ADAM17↓, 1,   pH↓, 2,   pH↑, 1,   e-pH↑, 2,   i-pH↓, 1,   TAMS↓, 2,   TAMS↝, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   CAXII/CA12↑, 1,   ChE↓, 1,   PTN↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

6IL↑, 2,   ADRB2↓, 1,   AhR↓, 1,   AhR↑, 2,   AR↓, 24,   AR-V7?, 1,   COMT↓, 1,   CYP19?, 1,   CYP19↓, 2,   DHT↓, 1,   ER-α36↓, 3,   ER-α36↝, 1,   ER(estro)↓, 1,   ERα/ESR1↓, 1,   FGF21↓, 1,   NR1H4↑, 1,   NR3C2/MR↑, 2,   PPARα↓, 1,   PPARα↝, 1,   PPARγ↓, 3,   PPARγ↑, 9,   PRL↓, 1,   RANKL↓, 2,   SRC3↓, 1,   testos↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 2,   AKR1B10↓, 1,   BioAv↓, 49,   BioAv↑, 50,   BioAv↝, 16,   BioEnh?, 1,   BioEnh↑, 1,   chemoR↓, 2,   ChemoSen?, 1,   ChemoSen↓, 4,   ChemoSen↑, 235,   ChemoSen⇅, 1,   ChemoSen↝, 1,   ChemoSen∅, 1,   CompStab↓, 2,   CompStab↑, 4,   CYP1A1↓, 3,   CYP1A1↑, 4,   CYP1A2↓, 1,   CYP1A2↑, 1,   CYP1B1↓, 2,   CYP2A3/CYP2A6↓, 1,   CYP2E1↑, 1,   CYP3A4↓, 2,   DDS↑, 4,   Dose?, 11,   Dose↓, 3,   Dose↑, 7,   Dose⇅, 3,   Dose↝, 108,   Dose∅, 9,   DrugR↓, 2,   eff?, 1,   eff↓, 104,   eff↑, 145,   eff⇅, 3,   eff↝, 14,   eff∅, 4,   GSTA1↓, 1,   GSTA1↑, 1,   GSTP1/GSTπ↑, 1,   GSTZ1↓, 1,   Half-Life↓, 12,   Half-Life↑, 4,   Half-Life↝, 11,   Half-Life∅, 1,   MDR1↓, 11,   MRP↓, 1,   MRP1/ABCC1↓, 5,   MRP2↓, 1,   MRP5↓, 1,   P-gp/ABCB1↓, 20,   P-gp/ABCB1↑, 1,   P450↓, 3,   RadioS?, 1,   RadioS↑, 63,   RadioS↝, 1,   selectivity?, 1,   selectivity↑, 150,   selectivity↝, 1,   selectivity∅, 1,   Synergy↑, 98,   Synergy↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AFP?, 1,   AFP↓, 2,   ALAT↓, 5,   ALAT↑, 1,   ALB↑, 1,   ALP↓, 3,   ALP↑, 1,   AR↓, 24,   AST↓, 4,   AST↑, 1,   B2M↓, 1,   BloodF↓, 1,   BMD↑, 2,   BRAF↓, 1,   BRCA1↓, 3,   BUN↓, 1,   CRP↓, 2,   E6↓, 2,   E7↓, 2,   EGFR↓, 42,   p‑EGFR↓, 4,   ERα/ESR1↓, 1,   EZH2↓, 3,   Ferritin↓, 1,   Ferritin↑, 1,   FOXM1↓, 5,   HER2/EBBR2↓, 13,   p‑HER2/EBBR2↓, 1,   hTERT/TERT↓, 13,   IL6↓, 49,   IL6↑, 2,   KRAS↓, 1,   LDH↓, 12,   LDH↑, 4,   LDH↝, 2,   e-LDH↑, 1,   Maspin↑, 1,   Myc↓, 5,   Myc↑, 1,   NOS2↓, 1,   PD-L1↓, 10,   PD-L1↑, 3,   Polyps↓, 2,   PSA↓, 17,   TP53↓, 1,   TP53↑, 3,   TRIB3↑, 1,   Tumccf↓, 9,   Tumccf↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiCan↓, 3,   AntiCan↑, 87,   AntiCan∅, 1,   antiD↑, 1,   antiNeop↑, 6,   AntiTum↓, 2,   AntiTum↑, 37,   cachexia↓, 3,   cardioP↑, 6,   CardioT↓, 1,   CardioT↑, 1,   chemoP?, 1,   chemoP↑, 48,   chemoPv↑, 32,   ChemoSideEff↓, 5,   ChemoSideEff∅, 1,   fatigue↓, 1,   FTO↓, 1,   FTO↑, 2,   hepatoP↓, 1,   hepatoP↑, 9,   kidSt↓, 1,   neuroP↓, 1,   neuroP↑, 11,   NP/CIPN↓, 3,   OS↑, 30,   OS∅, 1,   Pain↓, 3,   PFS↑, 1,   PFS∅, 1,   Pin1↓, 2,   QoL↑, 11,   QoL∅, 1,   radioP↑, 15,   Remission↑, 2,   RenoP↑, 8,   Risk↓, 39,   Risk↑, 1,   Strength↑, 1,   TGFβR1↓, 1,   toxicity?, 1,   toxicity↓, 42,   toxicity↑, 6,   toxicity⇅, 1,   toxicity↝, 14,   toxicity∅, 3,   TumNum?, 1,   TumNum↓, 2,   TumVol?, 1,   TumVol↓, 58,   TumVol↑, 1,   TumVol∅, 1,   TumW↓, 30,   TumW∅, 1,   Weight↑, 1,   Weight∅, 4,   Wound Healing↓, 2,   Wound Healing↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↓, 1,   AntiP↑, 2,   Bacteria↓, 2,   GutMicro↑, 11,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Api↑, 1,   Ingr?, 4,   Ingr↑, 1,   Ingr↝, 18,  
Total Targets: 1504

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx?, 1,   antiOx↓, 8,   antiOx↑, 101,   mt-antiOx↑, 1,   ARE↑, 2,   Catalase↑, 33,   Fenton↓, 1,   GPx↑, 26,   GPx1↑, 1,   GPx4↑, 1,   GSH↓, 2,   GSH↑, 31,   GSR↑, 7,   GSTs↑, 8,   H2O2↓, 3,   HDL↓, 1,   HDL↑, 4,   HO-1?, 1,   HO-1↓, 2,   HO-1↑, 21,   hyperG↓, 1,   hyperG↝, 1,   Keap1↓, 4,   Keap1↝, 1,   lipid-P↓, 26,   MDA↓, 20,   MDA↑, 1,   MPO↓, 4,   NADH↓, 1,   NOX↓, 1,   NOX4↓, 1,   NQO1↑, 4,   NRF2↓, 2,   NRF2↑, 40,   RNS↓, 5,   ROS?, 3,   ROS↓, 83,   ROS↑, 7,   ROS⇅, 1,   ROS∅, 1,   mt-ROS?, 1,   selenoP↑, 1,   SOD↑, 36,   SOD1↑, 6,   SOD2↑, 3,   TAC↑, 4,   TBARS↓, 2,   VitC↑, 2,   VitE↓, 1,   VitE↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 3,   IronCh↝, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compII↑, 1,   compIII↑, 1,   DRP1/DNM1L↓, 1,   HSP60/HSPD1↓, 1,   Insulin↓, 1,   Insulin↑, 2,   MFN2↑, 1,   mitResp↑, 2,   mtDam↓, 1,   OCR↑, 1,   PGC-1α↝, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

15-LOX/ALOX15↓, 1,   ACSL4↓, 1,   ALAT↓, 9,   AMPK↑, 6,   ATP↓, 1,   ATP↑, 6,   CRM↑, 1,   ECAR↓, 1,   ECAR∅, 1,   glucose↓, 6,   glucose↑, 1,   glucose↝, 1,   GlucoseCon↑, 4,   glyC↓, 1,   Glycolysis↓, 1,   Glycolysis↑, 1,   GSK‐3β↓, 1,   GSK‐3β↑, 2,   HK2↑, 1,   HMG-CoA↓, 1,   LDHA↑, 1,   LDL↓, 7,   lipidLev↓, 2,   NADPH↓, 1,   SIRT1↑, 3,  

Cell Death(tgid=5) ⓘ

AIF↓, 1,   AIF↑, 1,   Apoptosis↓, 5,   ASC↓, 1,   BAX↓, 3,   BAX↑, 2,   Bcl-2↓, 2,   Bcl-2↑, 3,   Bcl-xL↑, 1,   Casp1↓, 1,   Casp12↓, 1,   Casp3↓, 8,   Casp3↑, 2,   cl‑Casp3↓, 1,   cl‑Casp8↓, 1,   cl‑Casp8↑, 1,   Casp9↓, 4,   Cyt‑c↓, 1,   Cyt‑c↑, 1,   Fas↓, 2,   FasL↓, 1,   Ferroptosis↓, 2,   GranB/GZMB↓, 1,   IAP1↓, 1,   iNOS↓, 11,   iNOS↑, 2,   necrosis↓, 1,   p38↓, 3,   p‑p38↓, 1,   survivin↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 1,   Akt↑, 6,   Akt↝, 1,   p‑Akt↑, 2,   ERK↓, 1,   p‑ERK↑, 1,   HGF/c-Met↑, 1,   IGF-1R↓, 1,   IKKα↓, 1,   IκB?, 1,   JAK↓, 1,   JAK2↑, 1,   JNK↓, 2,   JNK↑, 2,   p‑JNK↓, 4,   MAPK↓, 7,   MAPK↑, 1,   MAPK↝, 1,   mTOR↓, 3,   mTOR↑, 2,   PDGFR-BB↓, 1,   PI3K↓, 2,   PI3K↑, 5,   PKCδ↓, 1,   PKCδ↑, 1,   RIP1↓, 1,   STAT↓, 1,   STAT3↓, 2,   STAT3↑, 2,   STAT3↝, 1,   p‑STAT3↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 4,   ATF2↑, 1,   ATF4↓, 1,   cMyc↓, 1,   FOXO3↑, 1,   HDAC↓, 1,   HOTAIR↑, 1,   other?, 1,   other↓, 4,   other↑, 3,   other↝, 8,   PhotoS↑, 1,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 2,   CHOP/DDIT3↑, 1,   p‑eIF2α↓, 1,   ER Stress↓, 2,   GRP78/BiP↓, 1,   GRP78/BiP↑, 1,   GRP94↑, 1,   HSP27↓, 1,   HSP70/HSPA5↓, 1,   HSP70/HSPA5↑, 1,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3II↑, 2,   p62↑, 2,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 4,   P53↓, 2,   P53↑, 1,   PARP↑, 1,   PARP1↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 1,   E2Fs↑, 1,   P21↑, 2,   TumCCA↑, 2,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

p‑4E-BP1↓, 1,   Diff↑, 1,   Diff↝, 1,   EP2↓, 1,   FGF↑, 1,   HH↓, 1,   neuroG↑, 2,   NOTCH↓, 1,   TumCP↓, 10,   TumCP↑, 1,   Wnt↓, 1,   Wnt↑, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 8,   AP-1↓, 2,   BACH1↓, 1,   Ca+2↓, 2,   Ca+2↑, 1,   Ca+2↝, 1,   Cartilage↑, 1,   EMT↑, 1,   FAK↑, 1,   LAMs↑, 1,   MMP13↓, 1,   MMP2↓, 1,   MMP2↑, 1,   MMP9↓, 2,   Smad1↑, 1,   TGF-β↓, 2,   TGF-β↑, 3,   TumCI↓, 2,   TumCMig↓, 2,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 3,   angioG↑, 1,   E-sel↓, 1,   Hif1a↓, 1,   NO↓, 11,   VCAM-1↓, 4,   VEGF↓, 3,   VEGF↑, 1,  

Barriers & Transport(tgid=15) ⓘ

AQPs↓, 1,   BBB↓, 1,   BBB↑, 6,   BBB↝, 1,   GastroP↑, 3,   GLUT1↓, 1,   GLUT2↑, 1,   GLUT4↑, 2,   H+/K+-ATPase↓, 1,   IBI↑, 3,   MMP↓, 3,   MMP↑, 4,   MMP∅, 1,   SVCT-2↑, 1,   TRPV1↑, 1,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD25+↑, 1,   CD4+↑, 2,   COX1↓, 4,   COX2/PTGS2↓, 23,   COX2/PTGS2↑, 1,   FOXP3↑, 1,   HMGB1↓, 1,   ICAM-1↓, 4,   IFN-γ↓, 6,   IFN-γ↑, 1,   IL1↓, 2,   IL10↓, 2,   IL10↑, 3,   IL12↓, 2,   IL17↓, 1,   IL18↓, 1,   IL1β↓, 22,   IL2↓, 1,   IL23↓, 1,   IL4↓, 2,   IL4↑, 1,   IL6?, 1,   IL6↓, 22,   IL6↑, 1,   IL8↓, 4,   Imm↑, 11,   Imm⇅, 1,   Imm↝, 1,   Inflam?, 1,   Inflam↓, 106,   Inflam↑, 1,   IRF3↓, 2,   LPS↓, 1,   M2 MC↑, 1,   pol-M2 MC↑, 1,   MCP1/CCL2↓, 2,   MCP1/CCL2↑, 1,   MyD88↓, 2,   NF-kB?, 1,   NF-kB↓, 28,   NF-kB↑, 2,   NK cell↑, 1,   NLRP3↓, 6,   NLRP3↑, 2,   p65↓, 1,   PGE2↓, 6,   RAGE↓, 1,   SOCS-3↓, 1,   TLR2↓, 2,   TLR4↓, 6,   TLR4↑, 1,   TLR4∅, 1,   TNF-α?, 1,   TNF-α↓, 29,   TNF-α↑, 1,   Treg lymp↝, 1,   TRIF↓, 1,   β-HEX↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   5HT↑, 2,   Ach↑, 1,   AChE↓, 12,   AChE↑, 1,   BChE↓, 3,   BDNF↑, 7,   proBDNF↑, 1,   ChAT↑, 1,   GABA↑, 2,   MAOA↓, 1,   MAOB↓, 1,   NGF↑, 4,   TPH1↓, 1,   TrkB↑, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 3,   APP↓, 1,   Aβ↓, 10,   BACE/β-secretase↓, 3,   tau↓, 1,   p‑tau↓, 3,   XO↓, 1,   XO↝, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 1,   ACE2↓, 1,   AHR↓, 1,   Estro↓, 1,   PPARγ↑, 1,   testos↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 37,   BioAv↑, 49,   BioAv↝, 21,   BioEnh↑, 2,   CompStab↝, 1,   CYP1A1↑, 1,   CYP1A2↑, 1,   Dose↓, 1,   Dose↑, 2,   Dose↝, 15,   eff↓, 1,   eff↑, 9,   eff↝, 2,   GSTA1↑, 2,   Half-Life↓, 2,   Half-Life↑, 1,   Half-Life↝, 9,   Half-Life∅, 1,   P-gp/ABCB1↓, 1,   P450↓, 1,   P450↑, 1,   selectivity↑, 1,   Synergy↑, 4,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 9,   ALP↓, 2,   AST↓, 10,   BG↓, 1,   BloodF↑, 1,   BMD↑, 3,   BP↓, 7,   creat↓, 2,   CRP↓, 3,   HOMA↓, 1,   hs-CRP↓, 1,   IL6?, 1,   IL6↓, 22,   IL6↑, 1,   IRes↝, 1,   LDH↓, 4,   NOS2↓, 2,   RAGE↓, 1,   SpO2↑, 1,   TC↓, 2,   TG/TAG↓, 2,   Urea↓, 1,   VLDL↓, 1,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 1,   AntiAge↑, 7,   antiAll↑, 13,   AntiArt↑, 6,   AntiCan↓, 2,   AntiCan↑, 21,   antiCG↑, 2,   antiD↑, 1,   AntiDiabetic↓, 3,   AntiDiabetic↑, 22,   antiPs↑, 2,   AntiTum↑, 9,   ANXi↓, 1,   Bone Healing↑, 1,   cardioP?, 1,   cardioP↑, 34,   CardioT↓, 1,   chemoP↑, 8,   chemoPv↑, 5,   cognitive↓, 1,   cognitive↑, 16,   diuretic↑, 2,   hepatoP↓, 2,   hepatoP↑, 37,   Learn↑, 1,   memory↑, 14,   Mood↑, 1,   motorD↓, 1,   neuroP?, 1,   neuroP↓, 1,   neuroP↑, 59,   Obesity↓, 15,   OS↑, 1,   Pain↓, 1,   QoL↓, 1,   radioP↑, 3,   RenoP↓, 1,   RenoP↑, 14,   Risk↓, 2,   Sleep↑, 2,   Stress↓, 2,   Stroke↓, 11,   toxicity↓, 48,   toxicity↑, 3,   toxicity↝, 9,   toxicity∅, 12,   Weight↑, 1,   Wound Healing↑, 3,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 11,   AntiFungal↑, 4,   AntiP↓, 1,   AntiP↑, 3,   AntiViral↑, 13,   Bacteria↓, 21,   GutMicro↑, 16,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Api↑, 1,   CA↑, 1,   Catechins↑, 1,   FA↑, 1,   Fibre↑, 1,   GA↑, 1,   Ingr↑, 2,   Ingr↝, 7,   LT↑, 1,   Myr↑, 1,   Phen↑, 1,   Poly↑, 1,   QC↑, 2,  
Total Targets: 448

Scientific Paper Hit Count for: TumCP, Tumor Cell proliferation
44 Curcumin
25 Quercetin
24 Luteolin
24 Thymoquinone
23 Magnetic Fields
23 Shikonin
19 EGCG (Epigallocatechin Gallate)
19 Sulforaphane (mainly Broccoli)
18 Berberine
18 Resveratrol
18 Matrine
17 Phenethyl isothiocyanate
17 Kaempferol
17 Licochalcone A
16 Silver-NanoParticles
16 Radiotherapy/Radiation
16 Baicalein
14 Cisplatin
14 Apigenin (mainly Parsley)
14 Melatonin
14 Capsaicin
14 phytic acid, Inositol hexakisphosphate
13 Propolis -bee glue
13 Formononetin
13 Honokiol
13 Magnolol
12 Artemisinin
12 Fisetin
12 Garcinol
12 Lycopene
11 Ashwagandha(Withaferin A)
11 Astaxanthin
11 Boron
11 Metformin
11 Crocetin
11 Emodin
11 Isorhamnetin
11 Juglone
11 Nimbolide
10 Chrysin
10 itraconazole
10 Selenite (Sodium)
10 Silymarin (Milk Thistle) silibinin
10 Urolithin
9 Berbamine
9 Flaxseed/Linseed
9 Gallic acid
9 Hyperoside
9 Ivermectin
8 Citric Acid
8 5-fluorouracil
8 chitosan
8 Beta-Caryophyllene
8 chaetocin
8 Dandelion Root
8 HydroxyTyrosol
8 Isobavachalcone
8 Isoliquiritigenin
8 Licorice
7 Astragalus
7 Benzyl isothiocyanate
7 Anethole/trans-Anethole
7 Paclitaxel/Taxol
7 Bufalin/Huachansu
7 Centella asiatica / Gotu kola → asiaticoside
7 Eugenol
7 Evodiamine
7 Ferulic acid
7 Gambogic Acid
7 Ginkgetin
7 isoorientin
7 Linalool
7 mebendazole
7 Mangiferin
7 Piperlongumine
6 Boswellia (frankincense)
6 Chemotherapy
6 Carnosic acid
6 Rosmarinic acid
6 Celastrol
6 Carvone
6 Cucurbitacin
6 Diclofenac
6 Diindolylmethane
6 Ellagic acid
6 isoquercitrin
6 Lemongrass Extract/Citral
6 Morin
6 Mushroom Lion’s Mane, Hericium erinaceus
6 Phenylbutyrate
6 salinomycin
6 Zyflamend
5 Allyl isothiocyanate
5 DTS(dibenzyl trisulphide) from Anamu
5 Gemcitabine (Gemzar)
5 Betulinic acid
5 Carvacrol
5 Cinnamon
5 Copper and Cu NanoParticles
5 Deguelin
5 Indole-3-carbinol
5 D-limonene
5 Fucoidan
5 Galloflavin
5 Geraniol
5 Hydrogen Gas
5 Helleborus niger extracts – Christmas Rose
5 low dose naltrexone
5 Magnetic Field Rotating
5 Patchouli Oil (Pogostemon cablin)
5 Vitamin K2
4 Allicin (mainly Garlic)
4 Atorvastatin
4 brusatol
4 Celecoxib
4 Chlorogenic acid
4 Chlorophyllin
4 Photodynamic Therapy
4 Date Fruit Extract
4 Disulfiram
4 Genistein (soy isoflavone)
4 Fenbendazole
4 Ginger/6-Shogaol/Gingerol
4 iodine
4 Inositol
4 Lutein
4 Marjoram (Origanum majorana)
4 Phycocyanin
4 Piperine
4 Ursolic acid
3 1,8-Cineole
3 Alpha-Lipoic-Acid
3 Andrographis
3 Isovitexin
3 Aspirin
3 immunotherapy
3 Docetaxel
3 α-Bisabolol / Chamomile oil
3 Butyrate
3 Caffeic acid
3 Thymol-Thymus vulgaris
3 Chocolate
3 Cichoric acid / Chicoric acid
3 Cyclopamine
3 Cynaropicrin
3 Dichloroacetate
3 diet Methionine-Restricted Diet
3 Ginkgo biloba-EGb 761
3 Ginkgo biloba
3 Ginkgolide B
3 Vitamin C (Ascorbic Acid)
3 Lactoferrin/Talactoferrin
3 Methylene blue
3 Moringa oleifera
3 Mushroom Chaga, Inonotus obliquus
3 Oleuropein
3 Propyl gallate
3 Plumbagin
3 Pterostilbene
3 Selenium
3 Sesamin
3 Terpinen-4-ol / Tea Tree Oil
3 Aflavin-3,3′-digallate
3 VitK3,menadione
3 Walnut
3 Zerumbone
2 Sorafenib (brand name Nexavar)
2 3-bromopyruvate
2 Auranofin
2 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
2 Ascorbyl Palmitate
2 Arctigenin
2 Baicalin
2 Biochanin A
2 Isothiocyanates
2 Brucea javanica
2 Bacopa monnieri
2 Beetroot
2 Caffeic Acid Phenethyl Ester (CAPE)
2 Hydroxycinnamic-acid
2 Coenzyme Q10
2 Carica papaya leaf extract
2 Cynara scolymus/Globe Artichoke/Artichoke Extract
2 Dichloroacetophenone(2,2-)
2 diet FMD Fasting Mimicking Diet
2 diet Short Term Fasting
2 Echinacea
2 Eurycomanone
2 Flaxseed Oil
2 Arsenic trioxide
2 Ginkgolic acids
2 γ-linolenic acid (Borage Oil)
2 Graviola
2 Grapeseed extract
2 hydrogen sulfide
2 doxorubicin
2 Laetrile B17 Amygdalin
2 lambertianic acid
2 Lapachol
2 SDG/lignans
2 Mung Bean Sprouts
2 Modified Citrus Pectin
2 Lemon Balm/Melissa officinalis
2 Methylsulfonylmethane
2 Mistletoe/Viscum album Extracts
2 Naringin
2 Niclosamide (Niclocide)
2 Psoralidin
2 EMF
2 Rutin
2 α-Santalol/Sandalwood oil
2 Sulfasalazine
2 Salvia miltiorrhiza
2 Vitamin D3
1 2-DeoxyGlucose
1 Açaí, Euterpe oleracea
1 Glucose
1 SonoDynamic Therapy UltraSound
1 Zinc
1 Ajoene (compound of Garlic)
1 alpha Linolenic acid
1 Fennel Oil/Foeniculum vulgare
1 Aloe anthraquinones
1 beta-glucans
1 almonertinib
1 bempedoic acid
1 Bevacizumab (brand Avastin)
1 temozolomide
1 Bromelain
1 borneol
1 Bortezomib
1 Bruteridin(bergamot juice)
1 Black turtle bean
1 Bullatacin
1 hydroxychloroquine
1 Cat’s Claw
1 Cynanbungeigenin C (CBC) and D (CBD)
1 Cannabidiol
1 Camu camu
1 Camptothecin
1 irinotecan
1 Cranberry
1 CUSP9
1 Dasatinib/Phyrago
1 Dihydrocaffeic Acid
1 Electrical Pulses
1 Exercise
1 Vitamin E
1 ferumoxytol
1 Trastuzumab
1 tamoxifen
1 Vitamin A, Retinoic Acid
1 Shilajit/Fulvic Acid
1 Ginseng
1 Germacranolide sesquiterpene lactone
1 Siegesbeckia glabrescens
1 HydroxyCitric Acid
1 epipolythiodioxopiperazine / epipolythiopiperazine-2,5-dione
1 Hibiscus sabdariffa
1 Hops (Humulus lupulus)
1 Hyperthermia
1 Inoscavin A
1 Recombinant Methioninase
1 L-Theanine
1 Lactobacillus
1 MCT, metronomic chemo
1 Methyl Jasmonate
1 methylseleninic acid
1 Caffeine
1 Magnesium
1 Methylglyoxal
1 NTP, Non-Thermal Plasma,Cold Atmospheric Plasma
1 magnetic nanoparticles
1 Mucuna pruriens/Velvet Bean
1 Mushroom Maitake
1 nicotinamide adenine dinucleotide
1 Bicarbonate(Sodium)
1 Oroxylin-A
1 Oleocanthal
1 Proanthocyanidins
1 sericin
1 Purple Corn / Purple Maize
1 xanthohumol
1 Pomi-T
1 Propranolol
1 Gold NanoParticles
1 Rauwolfia serpentina/Indian Snakeroot
1 buckwheat sprouts
1 Oxaliplatin
1 Selenium NanoParticles
1 Lignans
1 diet Plant based
1 Spirulina(Arthrospira/Limnospira)
1 Spermidine
1 tetrathiomolybdate
1 Tumor Treating Fields
1 Turmerones
1 Usnic acid
1 Vitexin
1 Wogonin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:327  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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