Cancer Database Query Results

Scientific Papers found: Click to Expand⟱
3385- ART/DHA,    Interaction of artemisinin protects the activity of antioxidant enzyme catalase: A biophysical study
- Study, NA, NA
*NF-kB↑, *Catalase↑,
3386- ART/DHA,    Effects of Caffeine-Artemisinin Combination on Liver Function and Oxidative Stress in Selected Organs in 7,12-Dimethylbenzanthracene-Treated Rats
- in-vivo, Nor, NA
*MDA↑, *SOD↓, *GSH∅, *Catalase↓,
3387- ART/DHA,    Ferroptosis: A New Research Direction of Artemisinin and Its Derivatives in Anti-Cancer Treatment
- Review, Var, NA
BioAv↓, lipid-P↑, Ferroptosis↑, Iron↑, GPx4↓, GSH↓, P53↑, ER Stress↑, PERK↑, ATF4↑, GRP78/BiP↑, CHOP↑, ROS↑, NRF2↑,
3388- ART/DHA,    Keap1 Cystenine 151 as a Potential Target for Artemisitene-Induced Nrf2 Activation
- in-vitro, Lung, A549 - in-vitro, Nor, GP-293 - in-vitro, BC, MDA-MB-231
NRF2↑, ROS∅,
3389- ART/DHA,    Emerging mechanisms and applications of ferroptosis in the treatment of resistant cancers
- Review, Var, NA
GSH↓, ROS↑, NRF2↑, eff↑,
3390- ART/DHA,    Ferroptosis: The Silver Lining of Cancer Therapy
Ferroptosis↑, Iron↑, NCOA4↝, ROS↑, Fenton↑, Tf↓,
3345- ART/DHA,    Dihydroartemisinin-induced unfolded protein response feedback attenuates ferroptosis via PERK/ATF4/HSPA5 pathway in glioma cells
- in-vitro, GBM, NA
ROS↑, Ferroptosis↑, lipid-P↑, HSP70/HSPA5↑, ER Stress↑, ATF4↑, GRP78/BiP↑, MDA↑, GSH↓, eff↑, GPx4↑,
3391- ART/DHA,    Antitumor Activity of Artemisinin and Its Derivatives: From a Well-Known Antimalarial Agent to a Potential Anticancer Drug
- Review, Var, NA
TumCP↓, TumMeta↓, angioG↓, TumVol↓, BioAv↓, Half-Life↓, BioAv↑, eff↑, eff↓, ROS↑, selectivity↑, TumCCA↑, survivin↓, BAX↑, Casp3↓, Casp8↑, Casp9↑, CDC25↓, CycB/CCNB1↓, NF-kB↓, cycD1/CCND1↓, cycE/CCNE↓, E2Fs↓, P21↑, p27↑, ADP:ATP↑, MDM2↓, VEGF↓, IL8↓, COX2↓, MMP9↓, ER Stress↓, cMyc↓, GRP78/BiP↑, DNAdam↑, AP-1↓, MMP2↓, PKCδ↓, Raf↓, ERK↓, JNK↓, PCNA↓, CDK2↓, CDK4↓, TOP2↓, uPA↓, MMP7↓, TIMP2↑, Cdc42↑, E-cadherin↑,
3392- ART/DHA,    Artemisinin inhibits inflammatory response via regulating NF-κB and MAPK signaling pathways
- in-vitro, Nor, Hep3B - in-vivo, NA, NA
*Inflam↓, *NF-kB↓, *ROS↓, *p‑p38↓, *p‑ERK↓,
3393- ART/DHA,    Artemisinin-derived artemisitene blocks ROS-mediated NLRP3 inflammasome and alleviates ulcerative colitis
- in-vivo, Col, NA
*ROS↓, *NLRP3↓, *Inflam↓,
3394- ART/DHA,    Anticancer activities and mechanisms of heat-clearing and detoxicating traditional Chinese herbal medicine
IGF-1R↓,
3395- ART/DHA,    Artesunate Induces Ferroptosis in Hepatic Stellate Cells and Alleviates Liver Fibrosis via the ROCK1/ATF3 Axis
- in-vitro, NA, HSC-T6
*Ferroptosis↑, *GSH↓, *ROCK1↓,
3396- ART/DHA,    Progress on the study of the anticancer effects of artesunate
- Review, Var, NA
TumCP↓, TumCI↓, TumCMig↓, Apoptosis↑, Diff↑, TumAuto↑, angioG↓, TumCCA↑, ROS↑, AMPK↑, mTOR↑, ChemoSen↑, Tf↑, Ferroptosis↑, Ferritin↓, lipid-P↑, CDK1↑, CDK2↑, CDK4↑, CDK6↑, SIRT1↑, COX2↓, IL1β↓, survivin↓, DNAdam↑, RadioS↑,
3665- ART/DHA,    Artemisinin B Improves Learning and Memory Impairment in AD Dementia Mice by Suppressing Neuroinflammation
- Review, AD, NA
*Inflam↓, *NO↓, *IL1β↓, *IL6↓, *TNF-α↓, *MyD88↓, *NF-kB↓, *TLR4↓, *memory↑,
3666- ART/DHA,    Artemisinin Attenuates Amyloid-Induced Brain Inflammation and Memory Impairments by Modulating TLR4/NF-κB Signaling
- NA, AD, NA
*Inflam↓, *neuroP↑, *TLR4↓, *NF-kB↓, *memory↑, *ROS↓, *iNOS↓, *COX2↓, *cognitive↑,
3667- ART/DHA,    Artemisinin improves neurocognitive deficits associated with sepsis by activating the AMPK axis in microglia
- Review, Sepsis, NA
*cognitive↑, *neuroP↑, *TNF-α↓, *IL6↓, *NF-kB↓, *AMPK↑, *ROS↓, *Akt↑, *MCP1↓, *MIP2↓, *TGF-β↑, *Inflam↓,
573- ART/DHA,    Artesunate suppresses tumor growth and induces apoptosis through the modulation of multiple oncogenic cascades in a chronic myeloid leukemia xenograft mouse model
- vitro+vivo, NA, NA
p‑p38↓, p‑ERK↓, p‑CREB↓, p‑Chk2↓, p‑STAT5↓, p‑RSK↓, SOCS1↑, Apoptosis↑, Casp3↑,
576- ART/DHA,    Profiling of Multiple Targets of Artemisinin Activated by Hemin in Cancer Cell Proteome
- Analysis, NA, NA
GSTP1/GSTπ↓, TfR1/CD71↓,
575- ART/DHA,    Dihydroartemisinin initiates ferroptosis in glioblastoma through GPX4 inhibition
- in-vitro, GBM, U87MG
GPx4↓, xCT∅, ROS↑, Ferroptosis↑, ACSL4∅,
574- ART/DHA,    Dihydroartemisinin suppresses glioma proliferation and invasion via inhibition of the ADAM17 pathway
TumCP↓, TumCMig↓, TumCI↓, MMP17↓, p‑EGFR↓, p‑Akt↓,
572- ART/DHA,    High-throughput screening identifies artesunate as selective inhibitor of cancer stemness: Involvement of mitochondrial metabolism
CSCs↓, mtDam↑,
571- ART/DHA,  TMZ,    Artesunate enhances the therapeutic response of glioma cells to temozolomide by inhibition of homologous recombination and senescence
- vitro+vivo, GBM, A172 - vitro+vivo, GBM, U87MG
HR↓, RAD51↓, Apoptosis↑, necrosis↑, ROS↑, ChemoSen↑,
570- ART/DHA,    Artemisinin and its derivatives can significantly inhibit lung tumorigenesis and tumor metastasis through Wnt/β-catenin signaling
- vitro+vivo, NSCLC, A549 - vitro+vivo, NSCLC, H1299
TumCCA↑, CSCs↓, TumCI↓, TumCMig↓, TumCG↓, Wnt/(β-catenin)↓, Nanog↓, SOX2↓, OCT4↓, N-cadherin↓, Vim↓, E-cadherin↑,
561- ART/DHA,    Antitumor and immunomodulatory properties of artemether and its ability to reduce CD4+ CD25+ FoxP3+ T reg cells in vivo
- in-vivo, NA, NA
TumCG↓, CD4+↓, CD25+↓, FoxP3+↓, IL4↑,
556- ART/DHA,    Artemisinins as a novel anti-cancer therapy: Targeting a global cancer pandemic through drug repurposing
- Review, NA, NA
IL6↓, IL1↓, TNF-α↓, TGF-β↓, NF-kB↓, MIP2↓, PGE2↓, NO↓, Hif1a↓, KDR/FLK-1↓, VEGF↓, MMP2↓, TIMP2↑, ITGB1↑, NCAM↑, p‑ATM↑, p‑ATR↑, p‑CHK1↑, p‑Chk2↑, Wnt/(β-catenin)↓, PI3K↓, Akt↓, ERK↓, cMyc↓, mTOR↓, survivin↓, cMET↓, EGFR↓, cycD1/CCND1↓, cycE1↓, CDK4/6↓, p16↑, p27↑, Apoptosis↑, TumAuto↑, Ferroptosis↑, oncosis↑, TumCCA↑, ROS↑, DNAdam↑, RAD51↓, HR↓,
557- ART/DHA,    Artemisinin and Its Derivatives in Cancer Care
- Review, Var, NA
*BioAv↓, *BioAv↑, Apoptosis↑, EGFR↓, CD31↓, Ki-67↓, P53↓, TfR1/CD71↑, P-gp↓, PD-1↝,
555- ART/DHA,    Artemisinin as an anticancer drug: Recent advances in target profiling and mechanisms of action
- Review, NA, NA
STAT3↓,
558- ART/DHA,    Artemisinin and Its Synthetic Derivatives as a Possible Therapy for Cancer
- Review, NA, NA
ROS↑, oncosis↑, Apoptosis↑, LysoPr↑, TumAuto↑, Wnt/(β-catenin)↑, AMP↓, NF-kB↓, Myc↓, CREBBP↓, mTOR↓, E-cadherin↑,
559- ART/DHA,    Artemisinin and its derivatives: a promising cancer therapy
- Review, NA, NA
ROS↑,
560- ART/DHA,    Dihydroartemisinin shift the immune response towards Th1, inhibit the tumor growth in vitro and in vivo
- in-vivo, NA, NA
IL4↓, CD4+↓, CD25+↓, FoxP3+↓, Treg lymp↓,
562- ART/DHA,    Artesunate exerts an anti-immunosuppressive effect on cervical cancer by inhibiting PGE2 production and Foxp3 expression
- in-vivo, NA, HeLa
CD4+↓, CD25+↓, FoxP3+↓, Treg lymp↓, PGE2↓, FOXP3↓, COX2↓,
563- ART/DHA,    Artesunate down-regulates immunosuppression from colorectal cancer Colon26 and RKO cells in vitro by decreasing transforming growth factor β1 and interleukin-10
- in-vitro, Colon, colon26 - in-vitro, CRC, RKO
TGF-β↓, IL10↓,
564- ART/DHA,  Cisplatin,    Dihydroartemisinin as a Putative STAT3 Inhibitor, Suppresses the Growth of Head and Neck Squamous Cell Carcinoma by Targeting Jak2/STAT3 Signaling
- in-vitro, NA, HN30
JAK2↓, STAT3↓, MMP2↓, MMP9↓, Mcl-1↓, Bcl-xL↓, cycD1/CCND1↓, VEGF↓, TumCCA↑, ChemoSen↑,
565- ART/DHA,    Artesunate as an Anti-Cancer Agent Targets Stat-3 and Favorably Suppresses Hepatocellular Carcinoma
STAT↓, IL6↓, pro‑Casp3↝, Bcl-xL↝, survivin↝,
566- ART/DHA,  2DG,    Dihydroartemisinin inhibits glucose uptake and cooperates with glycolysis inhibitor to induce apoptosis in non-small cell lung carcinoma cells
- in-vitro, Lung, A549 - in-vitro, Lung, PC9
GlucoseCon↓, ATP↓, lactateProd↓, p‑S6↓, mTOR↓, GLUT1↓, Casp9↑, Casp8↑, Casp3↑, Cyt‑c↑, AIF↑, ROS↑,
569- ART/DHA,    Dihydroartemisinin exhibits anti-glioma stem cell activity through inhibiting p-AKT and activating caspase-3
- in-vitro, GBM, NA
TumCP↓, Apoptosis↑, TumCCA↑, Casp3↑, p‑Akt↓,
567- ART/DHA,    An Untargeted Proteomics and Systems-based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells
- in-vitro, Lung, BEAS-2B
NRF2↑, AP-1↑, NFAT↑,
568- ART/DHA,    Mechanism-Guided Design and Synthesis of a Mitochondria-Targeting Artemisinin Analogue with Enhanced Anticancer Activity
- in-vitro, NA, MDA-MB-231 - in-vitro, NA, HeLa - in-vitro, NA, SkBr3 - in-vitro, NA, HCT116
Iron↝,
1076- ART/DHA,    The Potential Mechanisms by which Artemisinin and Its Derivatives Induce Ferroptosis in the Treatment of Cancer
- Review, NA, NA
Ferroptosis↑, ROS↑, ER Stress↑, i-Iron↓, TumAuto↑, AMPK↑, mTOR↑, P70S6K↑, Fenton↑, lipid-P↑, ROS↑, ChemoSen↑, NRF2↑, NRF2↓,
1079- ART/DHA,    Artesunate inhibits the growth and induces apoptosis of human gastric cancer cells by downregulating COX-2
- in-vitro, GC, BGC-823 - in-vitro, GC, HGC27 - in-vitro, GC, MGC803
TumCP↓, Apoptosis↑, COX2↓, BAX↑, Bcl-2↓, Casp3↑, Casp9↑, MMP↓,
1099- ART/DHA,    Dihydroartemisinin inhibits IL-6-induced epithelial–mesenchymal transition in laryngeal squamous cell carcinoma via the miR-130b-3p/STAT3/β-catenin signaling pathway
- in-vitro, NA, NA
EMT↓, TumCI↓, STAT3↓, β-catenin/ZEB1↓,
1075- ART/DHA,    Artemisinin derivatives inactivate cancer-associated fibroblasts through suppressing TGF-β signaling in breast cancer
- in-vitro, Nor, L929
*TGF-β↓,
1074- ART/DHA,    Artemisinin attenuates lipopolysaccharide-stimulated proinflammatory responses by inhibiting NF-κB pathway in microglia cells
- in-vitro, Nor, BV2
*TNF-α↓, *IL6↓, *MCP1↓, *NO↓, *iNOS↓, *IκB↑,
1026- ART/DHA,    Artemisinin improves the efficiency of anti-PD-L1 therapy in T-cell lymphoma
Ferroptosis↑, ROS↑, ERK↓, PD-L1↓,
957- ART/DHA,    Artemisinin inhibits the development of esophageal cancer by targeting HIF-1α to reduce glycolysis levels
- in-vitro, ESCC, KYSE150 - in-vitro, ESCC, KYSE170
TumCP↓, TumMeta↓, Glycolysis↓, N-cadherin↓, PKM2↓, Hif1a↓,
976- ART/DHA,    Artemisinin selectively decreases functional levels of estrogen receptor-alpha and ablates estrogen-induced proliferation in human breast cancer cells
- in-vitro, BC, MCF-7
ERα/ESR1↓,
985- ART/DHA,    Artemisinin suppresses aerobic glycolysis in thyroid cancer cells by downregulating HIF-1a, which is increased by the XIST/miR-93/HIF-1a pathway
- in-vitro, Thyroid, TPC-1 - Human, NA, NA
XIST↓, Hif1a↓, Glycolysis↓, TumCCA↑, TumMeta↓,
5381- ART/DHA,    Artemisitene triggers calcium-dependent ferroptosis by disrupting the LSH-EWSR1 interaction in colorectal cancer
- in-vitro, CRC, HCT116 - in-vitro, Nor, NCM460 - in-vitro, CRC, HT29 - in-vitro, CRC, HCT8
Ferroptosis↑, CYP24A1↓, Ca+2↑, SCD1↓, FAO↑, lipid-P↑, eff↑, selectivity↑, other?,
5383- ART/DHA,    Artesunate is a drug used to treat severe malaria.
- Review, Var, NA
Half-Life?,
5382- ART/DHA,    A phase I study of intravenous artesunate in patients with advanced solid tumor malignancies
- Trial, Var, NA
AntiCan↑, Dose↝, Dose↝,

Showing Research Papers: 801 to 850 of 6604
Prev Page 17 of 133 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 6604

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress

Fenton↑, 2,   Ferroptosis↑, 9,   GPx4↓, 2,   GPx4↑, 1,   GSH↓, 3,   GSTP1/GSTπ↓, 1,   Iron↑, 2,   Iron↝, 1,   i-Iron↓, 1,   lipid-P↑, 5,   MDA↑, 1,   NRF2↓, 1,   NRF2↑, 5,   ROS↑, 15,   ROS∅, 1,   xCT∅, 1,  

Metal & Cofactor Biology

Ferritin↓, 1,   NCOA4↝, 1,   Tf↓, 1,   Tf↑, 1,   TfR1/CD71↓, 1,   TfR1/CD71↑, 1,  

Mitochondria & Bioenergetics

ADP:ATP↑, 1,   AIF↑, 1,   ATP↓, 1,   CDC25↓, 1,   MMP↓, 1,   mtDam↑, 1,   Raf↓, 1,  

Core Metabolism/Glycolysis

ACSL4∅, 1,   AMP↓, 1,   AMPK↑, 2,   cMyc↓, 2,   p‑CREB↓, 1,   FAO↑, 1,   GlucoseCon↓, 1,   Glycolysis↓, 2,   lactateProd↓, 1,   PKM2↓, 1,   p‑S6↓, 1,   SCD1↓, 1,   SIRT1↑, 1,  

Cell Death

Akt↓, 1,   p‑Akt↓, 2,   Apoptosis↑, 8,   BAX↑, 2,   Bcl-2↓, 1,   Bcl-xL↓, 1,   Bcl-xL↝, 1,   Casp3↓, 1,   Casp3↑, 4,   pro‑Casp3↝, 1,   Casp8↑, 2,   Casp9↑, 3,   p‑Chk2↓, 1,   p‑Chk2↑, 1,   Cyt‑c↑, 1,   Ferroptosis↑, 9,   JNK↓, 1,   Mcl-1↓, 1,   MDM2↓, 1,   Myc↓, 1,   necrosis↑, 1,   oncosis↑, 2,   p27↑, 2,   p‑p38↓, 1,   p‑RSK↓, 1,   survivin↓, 3,   survivin↝, 1,  

Transcription & Epigenetics

other?, 1,  

Protein Folding & ER Stress

CHOP↑, 1,   ER Stress↓, 1,   ER Stress↑, 3,   GRP78/BiP↑, 3,   HSP70/HSPA5↑, 1,   PERK↑, 1,  

Autophagy & Lysosomes

TumAuto↑, 4,  

DNA Damage & Repair

p‑ATM↑, 1,   p‑ATR↑, 1,   p‑CHK1↑, 1,   DNAdam↑, 3,   HR↓, 2,   p16↑, 1,   P53↓, 1,   P53↑, 1,   PCNA↓, 1,   RAD51↓, 2,  

Cell Cycle & Senescence

CDK1↑, 1,   CDK2↓, 1,   CDK2↑, 1,   CDK4↓, 1,   CDK4↑, 1,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 3,   cycE/CCNE↓, 1,   cycE1↓, 1,   E2Fs↓, 1,   P21↑, 1,   TumCCA↑, 7,  

Proliferation, Differentiation & Cell State

cMET↓, 1,   CREBBP↓, 1,   CSCs↓, 2,   Diff↑, 1,   EMT↓, 1,   ERK↓, 3,   p‑ERK↓, 1,   IGF-1R↓, 1,   mTOR↓, 3,   mTOR↑, 2,   Nanog↓, 1,   OCT4↓, 1,   P70S6K↑, 1,   PI3K↓, 1,   SOX2↓, 1,   STAT↓, 1,   STAT3↓, 3,   p‑STAT5↓, 1,   TOP2↓, 1,   TumCG↓, 2,   Wnt/(β-catenin)↓, 2,   Wnt/(β-catenin)↑, 1,  

Migration

AP-1↓, 1,   AP-1↑, 1,   Ca+2↑, 1,   CD31↓, 1,   Cdc42↑, 1,   CDK4/6↓, 1,   E-cadherin↑, 3,   ITGB1↑, 1,   Ki-67↓, 1,   LysoPr↑, 1,   MMP17↓, 1,   MMP2↓, 3,   MMP7↓, 1,   MMP9↓, 2,   N-cadherin↓, 2,   NCAM↑, 1,   NFAT↑, 1,   PKCδ↓, 1,   TGF-β↓, 2,   TIMP2↑, 2,   Treg lymp↓, 2,   TumCI↓, 4,   TumCMig↓, 3,   TumCP↓, 6,   TumMeta↓, 3,   uPA↓, 1,   Vim↓, 1,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature

angioG↓, 2,   ATF4↑, 2,   EGFR↓, 2,   p‑EGFR↓, 1,   Hif1a↓, 3,   KDR/FLK-1↓, 1,   NO↓, 1,   VEGF↓, 3,  

Barriers & Transport

GLUT1↓, 1,   P-gp↓, 1,  

Immune & Inflammatory Signaling

CD25+↓, 3,   CD4+↓, 3,   COX2↓, 4,   FOXP3↓, 1,   FoxP3+↓, 3,   IL1↓, 1,   IL10↓, 1,   IL1β↓, 1,   IL4↓, 1,   IL4↑, 1,   IL6↓, 2,   IL8↓, 1,   JAK2↓, 1,   MIP2↓, 1,   NF-kB↓, 3,   PD-1↝, 1,   PD-L1↓, 1,   PGE2↓, 2,   SOCS1↑, 1,   TNF-α↓, 1,  

Hormonal & Nuclear Receptors

CDK6↑, 1,   CYP24A1↓, 1,   ERα/ESR1↓, 1,  

Drug Metabolism & Resistance

BioAv↓, 2,   BioAv↑, 1,   ChemoSen↑, 4,   Dose↝, 2,   eff↓, 1,   eff↑, 4,   Half-Life?, 1,   Half-Life↓, 1,   RadioS↑, 1,   selectivity↑, 2,  

Clinical Biomarkers

EGFR↓, 2,   p‑EGFR↓, 1,   ERα/ESR1↓, 1,   Ferritin↓, 1,   IL6↓, 2,   Ki-67↓, 1,   Myc↓, 1,   PD-L1↓, 1,   XIST↓, 1,  

Functional Outcomes

AntiCan↑, 1,   TumVol↓, 1,  
Total Targets: 203

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress

Catalase↓, 1,   Catalase↑, 1,   Ferroptosis↑, 1,   GSH↓, 1,   GSH∅, 1,   MDA↑, 1,   ROS↓, 4,   SOD↓, 1,  

Core Metabolism/Glycolysis

AMPK↑, 1,  

Cell Death

Akt↑, 1,   Ferroptosis↑, 1,   iNOS↓, 2,   p‑p38↓, 1,  

Proliferation, Differentiation & Cell State

p‑ERK↓, 1,  

Migration

ROCK1↓, 1,   TGF-β↓, 1,   TGF-β↑, 1,  

Angiogenesis & Vasculature

NO↓, 2,  

Immune & Inflammatory Signaling

COX2↓, 1,   IL1β↓, 1,   IL6↓, 3,   Inflam↓, 5,   IκB↑, 1,   MCP1↓, 2,   MIP2↓, 1,   MyD88↓, 1,   NF-kB↓, 4,   NF-kB↑, 1,   TLR4↓, 2,   TNF-α↓, 3,  

Protein Aggregation

NLRP3↓, 1,  

Drug Metabolism & Resistance

BioAv↓, 1,   BioAv↑, 1,  

Clinical Biomarkers

IL6↓, 3,  

Functional Outcomes

cognitive↑, 2,   memory↑, 2,   neuroP↑, 2,  
Total Targets: 37

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:%  State#:%  Dir#:%
wNotes=0 sortOrder:rid,rpid

 

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