TumCCA Cancer Research Results

TumCCA, Tumor cell cycle arrest: Click to Expand ⟱
Source:
Type:
Tumor cell cycle arrest refers to the process by which cancer cells stop progressing through the cell cycle, which is the series of phases that a cell goes through to divide and replicate. This arrest can occur at various checkpoints in the cell cycle, including the G1, S, G2, and M phases. S, G1, G2, and M are the four phases of mitosis.
Scientific Papers found: Click to Expand⟱
8518- MAG,    Magnolol suppresses the proliferation and invasion of cholangiocarcinoma cells via inhibiting the NF-κB signaling pathway
- in-vitro, CCA, NA
TumCG↓, TumCMig↓, TumCI↓, PCNA↓, Ki-67↓, MMP2↓, MMP7↓, MMP9↓, TumCCA↑, cycD1/CCND1↓, p‑IκB↓, p‑p65↓, NF-kB↓,
8497- MAG,    Magnolol induces apoptosis in MCF-7 human breast cancer cells through G2/M phase arrest and caspase-independent pathway
- in-vitro, BC, MCF7
TumCP↓, Apoptosis↑, *TumCCA↑, *ROS↑, *MMP↓, *Cyt‑c↑, *AIF↑, *BAX↑, *P21↑, *P53↑, *Bcl-2↓, *CycB/CCNB1↓, *CDK1↓,
8498- MAG,    Induction of apoptosis by magnolol via the mitochondrial pathway and cell cycle arrest in renal carcinoma cells
- in-vitro, Kidney, 786-O - in-vitro, RCC, OS-RC-2 - in-vitro, Nor, HK-2
Apoptosis↑, TumCCA↑, selectivity↑, TumCMig↓, TumCI↓, MPT↑, ROS↓, MMP↓, mtDam↑,
8505- MAG,    Role of magnolol in gastrointestinal cancers: Recent trends and future perspectives
- Review, GC, NA
TumCP↓, TumCI↓, TumCMig↓, angioG↓, EMT↓, TumCCA↑, Apoptosis↑, PI3K↝, Akt↝, NF-kB↝, MAPK↝, JNK↝, ERK↝, TGF-β↝, Smad1↝,
8516- MAG,    Magnolol induces cell death through PI3K/Akt-mediated epigenetic modifications boosting treatment of BRAF- and NRAS-mutant melanoma
- in-vitro, Melanoma, NA
TumCCA↑, Apoptosis↑, TumCD↑, PI3K↓, Akt↓, H3K4↓, ChemoSen↑,
4533- MAG,    Magnolol, a natural compound, induces apoptosis of SGC-7901 human gastric adenocarcinoma cells via the mitochondrial and PI3K/Akt signaling pathways
- in-vitro, GC, SGC-7901
AntiCan↑, DNAdam↑, Apoptosis↑, TumCCA↑, Bax:Bcl2↑, MMP↓, Casp3↑, PI3K↓, Akt↓,
4514- MAG,    Magnolol and its semi-synthetic derivatives: a comprehensive review of anti-cancer mechanisms, pharmacokinetics, and future therapeutic potential
- Review, Var, NA
AntiCan↑, TumCP↓, TumCCA↑, TumMeta↓, angioG↓, NF-kB↓, MAPK↓, PI3K↓, Akt↓, mTOR↓, BioAv↓, *antiOx↑, *Inflam↓, *AntiAg↑, ChemoSen↑, cycD1/CCND1↓, CycB/CCNB1↓, cycE/CCNE↓, CDK2↓, CDK4↓, p27/CDKN1B↑, P21↑, P53↑, PTEN↓, XIAP↓, Mcl-1↓, Casp3↑, Casp9↑, MMP9↑,
4515- MAG,    Magnolol as a Potential Anticancer Agent: A Proposed Mechanistic Insight
- Review, Var, NA
AntiCan↑, TumCP↓, TumCCA↑, Apoptosis↑, TumCMig↑, angioG↓, PI3K↓, Akt↓, mTOR↓, MAPK↓, NF-kB↓,
4516- MAG,    Magnolol Induces Apoptosis and Suppresses Immune Evasion in Non-small Cell Lung Cancer Xenograft Models
- in-vivo, NSCLC, NA
selectivity↑, Apoptosis↑, TumCCA↑, Casp3↑, cycD1/CCND1↓, CDK4↓, VEGF↓, FOXP3↓, IDO1↓,
4536- MAG,    Magnolol suppresses proliferation of cultured human colon and liver cancer cells by inhibiting DNA synthesis and activating apoptosis
- in-vitro, Liver, HepG2 - in-vivo, CRC, COLO205
AntiCan↑, selectivity↑, TumCCA↑, P21↑, Apoptosis↑,
4537- MAG,    Effects of magnolol on UVB-induced skin cancer development in mice and its possible mechanism of action
- in-vivo, Melanoma, NA - in-vitro, Melanoma, A431
*cl‑Casp8↑, *PARP↑, *P21↑, tumCV↓, TumCP↓, TumCCA↑, CycB/CCNB1↓, cycA1/CCNA1↓, CDK4↓, CDC2↓, P21↑, Apoptosis↑,
4528- MAG,    Pharmacology, Toxicity, Bioavailability, and Formulation of Magnolol: An Update
- Review, Nor, NA
*Inflam↑, *cardioP↑, *angioG↓, *antiOx↑, *neuroP↑, *Bacteria↓, AntiTum↑, TumCG↓, TumCMig↓, TumCI↓, Apoptosis↑, E-cadherin↑, NF-kB↓, TumCCA↑, cycD1/CCND1↓, PCNA↓, Ki-67↓, MMP2↓, MMP7↓, MMP9↓, TumCG↓, Casp3↑, NF-kB↓, Akt↓, mTOR↓, LDH↓, Ca+2↑, Synergy↑, *toxicity↓, *BioAv↝, *PGE2↓, *TLR2↓, *TLR4↓, *MAPK↓, *PPARγ↓,
4519- MAG,    Magnolol: A Neolignan from the Magnolia Family for the Prevention and Treatment of Cancer
- Review, Var, NA
*antiOx↑, *Inflam↓, *Bacteria↓, *AntiAg↑, *BBB↑, *BioAv↓, BAD↑, Casp3↑, Casp6↑, Casp9↑, JNK↑, Bcl-xL↓, PTEN↑, Akt↓, NF-kB↓, MMP7↓, MMP9↓, uPA↓, Hif1a↓, VEGF↓, FOXO3↓, Ca+2↑, TumCCA↑, ROS↑, Cyt‑c↑,
8561- Matr,    Matrine triggers colon cancer cell apoptosis and G0/G1 cell cycle arrest via mediation of microRNA-22
- in-vitro, Colon, SW480 - in-vitro, CRC, SW-620
Dose↝, tumCV↓, Apoptosis↑, TumCCA↑, miR-22↑, Wnt↓, β-catenin/ZEB1↓, MEK↓, ERK↓,
8567- Matr,    Matrine induces apoptosis in multiple colorectal cancer cell lines in vitro and inhibits tumour growth with minimum side effects in vivo via Bcl-2 and caspase-3
- vitro+vivo, CRC, NA
TumCP↓, TumCCA↑, Bcl-2↓, BAX↑, cl‑Casp3↑, TumCG?, toxicity↓,
8542- Matr,    Matrine Suppresses Lung Cancer Progression via Dual Inhibition of CHEK1-Mediated DNA Damage Repair and PI3K/AKT Survival Signaling
- vitro+vivo, Lung, A549
TumCP↓, TumCMig↓, TumCI↓, TumCCA↑, p‑PI3K↓, CHK1↓, p‑Akt↓, Bcl-2↓, MTA1↓, Vim↓, MMP2↓, MMP9↓, γH2AX↑, E-cadherin↑, BAX↑, cl‑Casp3↑, Ki-67↓, TumCG↓,
8560- Matr,    Matrine: A Promising Natural Product With Various Pharmacological Activities
- Review, AD, NA - Review, Stroke, NA - Review, Var, NA
*antiAll↑, *Stroke↓, *AntiArt↑, TumCCA↑, VEGF↓, Apoptosis↑, P53↑, P21↑, PCNA↓, EIF4E↓, TumCP↓, TumCMig↓, IAP1↓, ROS↑, EMT↓, PAX2↓, ER Stress↑, HK2↓, Apoptosis↑, STAT3↓, mtDam↑, HMGB1↓, ChemoSen↑, p‑GSK‐3β↓, P-gp/ABCB1↓, MRP1/ABCC1↓, Vim↓, cycD1/CCND1↓, CDK4↓, GSH↓, SOD↓, mt-Cyt‑c↓, BAX↑, MMP9↓, MMP2↓, E-cadherin↓, N-cadherin↓, FOXO1↓, FOXO3↓, FOXO4↓, PI3K↓, ATF4↑, CHOP/DDIT3↑, *Aβ↓, *RAGE↓, *memory↑, *Learn↑, *cognitive↑, *MDA↓, *SOD↑, *GPx↑, *Catalase↑, *antiAll↑, *AHR↓, *SOCS-3↓, *ICAM-1↓, *ROS↓, cachexia↓, *BACE/β-secretase↓, *NF-kB↓, *TNF-α↓, *IL1β↓,
8554- Matr,    Matrine injection inhibits pancreatic cancer growth via modulating carbonic anhydrases- a network pharmacology-based study with in vitro validation
- in-vitro, PC, Capan1 - in-vitro, PC, MIA PaCa-2
TumCP↓, TumCCA↑, Apoptosis↑, CAIX/CA9↓, CAXII/CA12↑,
8553- Matr,    Research progress on the pharmacological effects of matrine
- Review, Nor, NA
*AntiCan↑, *antiAll↑, *Stroke↓, TumCI↓, TumCMig↓, TumCP↓, TumCCA↑, *AGEs↓, *Inflam↓, *antiOx↑, *neuroP↑, *Apoptosis↓, *IBI↑, *GutMicro↑, EGFR↓, *HSP60/HSPD1↓, *antiOx↑, *GSH↑, *Catalase↑, *AChE↓, *BChE↓, *neuroP↑, *PI3K↑, *Akt↑, *mTOR↑, *cognitive↑, *ROS↓, *toxicity↑,
8923- MBS,    Novel molecular, cytotoxical, and immunological study on promising and selective anticancer activity of Mung bean sprouts
- in-vitro, Cerv, HeLa - in-vitro, Liver, HepG2
*Apoptosis↑, *TumCCA↑, *AntiCan↑,
8627- MBZ,    Treatment of breast and colon cancer cell lines with anti-helmintic benzimidazoles mebendazole or albendazole results in selective apoptotic cell death
- in-vitro, CRC, HT-29 - in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231
TumCD↑, selectivity↑, Apoptosis↑, Casp3↑, DNAdam↑, MOMP↑, ROS↑, TumCCA↑, eff↓, RadioS↑,
8632- MBZ,    Mebendazole elicits a potent antitumor effect on human cancer cell lines both in vitro and in vivo
- vitro+vivo, Lung, NA
Apoptosis↑, TumCCA?, Cyt‑c↑, selectivity↑,
8634- MBZ,  Rad,    Mebendazole Potentiates Radiation Therapy in Triple-Negative Breast Cancer
- vitro+vivo, BC, MCF7 - in-vitro, BC, T47D - in-vitro, BC, MDA-MB-231
RadioS↑, TumCCA↑, DNAdam↑, Apoptosis↑, TumCD↑, *toxicity↓,
8635- MBZ,    The repurposed anthelmintic mebendazole in combination with trametinib suppresses refractory NRASQ61K melanoma
- vitro+vivo, Melanoma, NA
TumCCA↑, cMyc↓, cl‑Casp3↑, cl‑PARP↑, eff↑, TumCP↓, BRAF↓, OS↑, TumCG↓, p‑MEK↓, p‑ERK↓,
8641- MBZ,  ONC201,    The therapeutic potential of repurposed mebendazole, alone and in synergistic combination with ONC201, in the treatment of diffuse midline glioma
- in-vitro, GBM, NA
TumCCA↑, P21↑, p27/CDKN1B↑, Apoptosis↑, Casp3↑, cl‑PARP↑, Synergy↑, ChemoSen↑,
8643- MBZ,    Mebendazole prevents distant organ metastases in part by decreasing ITGβ4 expression and cancer stemness
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, 4T1 - in-vitro, BC, SUM159
*toxicity↓, TumCP↓, Apoptosis↑, TumCCA↑, TumVol↓, TumMeta↓, ITGB4↓, CSCs↓, Dose↝, TumCMig↓,
8653- MBZ,  Cisplatin,    Anthelmintic mebendazole enhances cisplatin's effect on suppressing cell proliferation and promotes differentiation of head and neck squamous cell carcinoma (HNSCC)
- in-vitro, HNSCC, CAL27 - in-vitro, HNSCC, SCC-154
TumCP↓, TumCCA↑, TumCMig↓, Apoptosis↑, ChemoSen↑,
8650- MBZ,    Autophagy Is a Potential Target for Enhancing the Anti-Angiogenic Effect of Mebendazole in Endothelial Cells
- in-vitro, Var, NA
TumCP↓, TumCCA↑, Apoptosis↑, DNAdam↑, P53↑, Casp3↑, TumAuto↑, Synergy↑, eff↑,
8649- MBZ,    Mebendazole induces apoptosis via C-MYC inactivation in malignant ascites cell line (AGP01)
- in-vitro, GC, AGP01
TumCCA↑, Apoptosis↑, Casp3↑, Casp7↑, cMyc↓,
8786- mCHEMO,    Metronomic chemotherapy in cancer treatment: new wine in an old bottle
- Review, Var, NA
eff↑, ChemoSideEff↓, angioG↓, *toxicity↓, PFS↑, Hif1a↓, TumCD↑, CSCs↓, EMT↓, Bcl-2↓, BAX↑, Casp3↑, Casp7↑, CD133↓, TumCCA↑, P21↓, DNAdam↑, Imm↑, Synergy↑, Synergy↑,
8821- MCP,  Rad,    Modified Citrus Pectin as a Potential Sensitizer for Radiotherapy in Prostate Cancer
- in-vitro, Pca, PC3 - in-vitro, Pca, DU145
Gal-3↓, TumCP↓, angioG↓, Apoptosis↑, RadioS?, BAX↓, DNArepair↓, PCNA↓, TumCI↓, TumCCA↑, ROS↑,
8822- MCP,    Modified citrus pectin inhibited bladder tumor growth through downregulation of galectin-3
- vitro+vivo, CRC, T24/HTB-9 - in-vitro, Bladder, J82
TumCCA↑, cycD1/CCND1↓, p‑cDC2↓, Casp3↑, cl‑Casp3↑, cl‑PARP↑, Gal-3↓, Akt↓, TumCG↓, Ki-67↓, Dose⇅,
8715- MeJa,    Methyl jasmonate decreases membrane fluidity and induces apoptosis via tumor necrosis factor receptor 1 in breast cancer cells
- in-vitro, BC, MDA-MB-453 - in-vitro, BC, MCF-10AT
TumCG↓, TumCCA↑, memfluid↓, TNFR 1↑, MAPK↑, Casp8↑, MMP↓, Apoptosis↑, p38↑, ERK↑, Casp3↑,
8717- MeJa,    Methyl jasmonate induces apoptosis and pro-apoptotic autophagy via the ROS pathway in human non-small cell lung cancer
- in-vitro, NSCLC, A549 - in-vitro, Lung, Calu-1 - in-vitro, Lung, H157 - in-vitro, Lung, H1792
TumCCA↑, Apoptosis↑, selectivity↑, cFLIP↓, ROS↑, DR5↑, CHOP/DDIT3↑, TumAuto↑,
8720- MeJa,    Methyl jasmonate downregulates expression of proliferating cell nuclear antigen and induces apoptosis in human neuroblastoma cell lines
- in-vitro, neuroblastoma, SK-N-SH
PCNA↓, TumCCA↑, XIAP↓, survivin↓,
8718- MeJa,    Methyl jasmonate induces apoptosis through induction of Bax/Bcl-XS and activation of caspase-3 via ROS production in A549 cells
- in-vitro, Lung, A549
TumCCA↑, Apoptosis↑, selectivity↑, BAX↑, Casp3↑, ROS↑,
8757- MeSA,    Methylseleninic acid (MSA) inhibits 17β-estradiol-induced cell growth in breast cancer T47D cells via enhancement of the antioxidative thioredoxin/ thioredoxin reductase system
- in-vitro, BC, T47D
ER-α36↓, TumCCA↑, Synergy↑, Trx↑, TrxR↑, ROS↓, other↝,
8751- MeSA,  PacT,    Methylseleninic acid enhances paclitaxel efficacy for the treatment of triple-negative breast cancer
- vitro+vivo, BC, MDA-MB-231
ChemoSen↑, Casp↑, Apoptosis↑, TumCCA↑, TumCP↓, TumCG↓,
8742- MeSA,    Distinct effects of methylseleninic acid versus selenite on apoptosis, cell cycle, and protein kinase pathways in DU145 human prostate cancer cells
- in-vitro, Pca, DU145
TumCCA↑, DNAdam↑, Casp↑, cl‑PARP↑, p27/CDKN1B↑, P21↑, Apoptosis↑, Akt↓, ERK↓,
8759- MeSA,    Methylseleninic acid induces apoptosis of human bladder cancer cells through the ROS-mediated mitochondrial pathway
- in-vitro, Bladder, J82 - in-vitro, CRC, T24/HTB-9
tumCV↓, TumCCA↑, Apoptosis↑, ROS↑, MMP↓, eff↓, BAX↑, Bcl-2↓, Cyt‑c↑, Casp9↑, Casp3↑,
8764- MeSA,    Methylseleninic acid promotes antitumour effects via nuclear FOXO3a translocation through Akt inhibition
- in-vitro, Lung, A549
FOXO3↑, DNAdam↑, ROS↓, TumCCA↑, Apoptosis↑, ChemoSen↑, Glycolysis↓, TCA↓, Synergy↑,
2384- MET,    Integration of metabolomics and transcriptomics reveals metformin suppresses thyroid cancer progression via inhibiting glycolysis and restraining DNA replication
- in-vitro, Thyroid, BCPAP - in-vivo, NA, NA - in-vitro, Thyroid, TPC-1
Glycolysis↓, OXPHOS↑, tumCV↓, TumCI↓, TumCMig↓, EMT↓, Apoptosis↑, TumCCA↑, LDHA↓, PKM2↓, IDH1↑, TumCG↓,
5803- MET,  carbop,    Metformin, at Concentrations Corresponding to the Treatment of Diabetes, Potentiates the Cytotoxic Effects of Carboplatin in Cultures of Ovarian Cancer Cells
- in-vitro, Ovarian, A2780S - in-vitro, Ovarian, SKOV3
eff↑, ChemoSen↑, TumCCA↑,
5795- MET,    Metformin: A Review of Potential Mechanism and Therapeutic Utility Beyond Diabetes
- Review, AD, NA - Review, Park, NA - Review, Diabetic, NA
*AntiDiabetic↑, *AMPK↑, *glyC↓, *ROS↓, *cardioP↑, *neuroP↑, *Half-Life↝, *toxicity↝, *BioAv↑, *glucose↓, *AGEs↓, AntiCan↑, Risk↓, TumCP↓, Apoptosis↑, TumCCA↑, cycD1/CCND1↓, pRB↓, p27/CDKN1B↓, mTOR↓, Casp↑, ROS↑, MMP↓, ChemoSen↑, *hepatoP↑, *CRM↑, *Insulin↓,
496- MF,    Low-Frequency Magnetic Fields (LF-MFs) Inhibit Proliferation by Triggering Apoptosis and Altering Cell Cycle Distribution in Breast Cancer Cells
- in-vitro, BC, MCF7 - in-vitro, BC, ZR-75-1 - in-vitro, BC, T47D - in-vitro, BC, MDA-MB-231
ROS↑, PI3K↓, Akt↓, GSK‐3β↑, Apoptosis↑, cl‑PARP↑, cl‑Casp3↑, BAX↑, Bcl-2↓, CycB/CCNB1↓, TumCCA↑, p‑Akt↓, TumCP↓, selectivity↑, eff↓,
524- MF,    Inhibition of Angiogenesis Mediated by Extremely Low-Frequency Magnetic Fields (ELF-MFs)
- vitro+vivo, PC, MS-1 - vitro+vivo, PC, HUVECs
other↓, TumCP↓, TumCMig↓, VEGFR2/KDR/Flk1↓, TumVol↓, HSP70/HSPA5↓, HSP90↓, TumCCA↑, angioG↓,
487- MF,    Extremely Low-Frequency Electromagnetic Fields Cause G1 Phase Arrest through the Activation of the ATM-Chk2-p21 Pathway
- in-vitro, NMSC, HaCaT
ATM↑, Chk2↑, P21↑, TumCCA↑,
497- MF,    In Vitro and in Vivo Study of the Effect of Osteogenic Pulsed Electromagnetic Fields on Breast and Lung Cancer Cells
- vitro+vivo, BC, MCF7 - vitro+vivo, Lung, A549
TumCG↓, TumVol↓, Casp3↑, Casp7↑, Apoptosis↑, DNAdam↑, TumCCA↑, ChemoSen↑, EPR↑,
508- MF,  doxoR,    Synergistic cytotoxic effects of an extremely low-frequency electromagnetic field with doxorubicin on MCF-7 cell line
- in-vitro, BC, MCF7
ROS↑, Apoptosis↑, TumCCA↑,
4353- MF,  Chemo,    Pulsed Electromagnetic Field Enhances Doxorubicin-induced Reduction in the Viability of MCF-7 Breast Cancer Cells
- in-vitro, BC, MCF7
TumCCA↑, Apoptosis↑, ChemoSen↑, TumCCA↑, Casp↝, p‑CDK2↓, cycE/CCNE↓, Fas↑, BAX↑, survivin↓, Mcl-1↓, cl‑PARP↑, cl‑Casp7↑, cl‑Casp8↑, cl‑Casp9↑,

Showing Research Papers: 801 to 850 of 1163
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1163

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 2,  

Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↑, 1,   antiOx↓, 6,   antiOx↑, 25,   antiOx⇅, 2,   ARE↑, 1,   ARE/EpRE↑, 1,   Catalase↓, 14,   Catalase↑, 7,   Copper↑, 1,   DJ-1↓, 1,   ENOX2↓, 1,   Fenton↑, 4,   GCLM↓, 1,   GPx↓, 3,   GPx↑, 5,   GPx1↓, 2,   GPx4↓, 20,   GPx4∅, 1,   GSH?, 1,   GSH↓, 65,   GSH↑, 10,   GSH⇅, 1,   GSH/GSSG↓, 3,   GSR↓, 2,   GSR↑, 1,   GSSG↓, 1,   GSTs↓, 4,   GSTs↑, 2,   GSTs↝, 1,   H2O2↓, 1,   H2O2↑, 10,   HO-1↓, 6,   HO-1↑, 25,   HO-2↓, 1,   Iron↓, 3,   Iron↑, 8,   Iron↝, 1,   i-Iron↑, 2,   c-Iron↑, 1,   Keap1↓, 1,   Keap1↑, 2,   lipid-P↓, 5,   lipid-P↑, 33,   MDA↓, 6,   MDA↑, 13,   i-MDA↑, 1,   NADH↓, 2,   mt-NADH↓, 1,   mt-NADH↑, 1,   NOX4↑, 1,   NQO1?, 1,   NQO1↓, 4,   NQO1↑, 4,   Nrf1↑, 1,   NRF2↓, 29,   NRF2↑, 34,   NRF2⇅, 1,   NRF2↝, 1,   Prx↓, 2,   Prx4↑, 1,   Prx6↑, 1,   PrxII↓, 2,   PYCR1↓, 1,   RNS↑, 2,   ROS?, 3,   ROS↓, 51,   ROS↑, 534,   ROS⇅, 11,   ROS↝, 4,   ROS∅, 4,   i-ROS?, 1,   i-ROS↓, 1,   i-ROS↑, 5,   mt-ROS↑, 9,   SOD?, 1,   SOD↓, 16,   SOD↑, 11,   SOD1↓, 2,   SOD1↑, 1,   SOD2↓, 5,   mt-SOD2↑, 1,   TBARS↓, 1,   TBARS↑, 1,   Thiols↓, 2,   TKT↓, 1,   Trx↓, 7,   Trx↑, 1,   Trx1↓, 1,   Trx1↑, 2,   ox-Trx1↑, 1,   TrxR↓, 12,   TrxR↑, 1,   TrxR1↓, 8,   TrxR1↑, 1,   xCT/SLC7A11↓, 5,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 2,   FTH1↓, 2,   IronCh↑, 3,   Mets↑, 1,   NCOA4↑, 1,   Tf↓, 1,   Tf↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↑, 1,   BCR↓, 1,   BCR-ABL↓, 1,   CDC16↓, 1,   CDC2↓, 12,   p‑CDC2↓, 1,   CDC25↓, 30,   CDC25↑, 2,   CDC25↝, 1,   p‑CDC25↑, 1,   compI↓, 4,   compII↓, 2,   compIII↓, 1,   compV↓, 1,   EGF↓, 6,   EGF↑, 1,   ETC↓, 7,   HSP60/HSPD1↓, 2,   HSP60/HSPD1↑, 1,   IDH2↓, 1,   Insulin↓, 1,   MFN2↑, 1,   mitResp↓, 6,   mitResp↑, 2,   MKK7↓, 1,   Mortalin↓, 1,   mtDam↓, 3,   mtDam↑, 44,   OCR↓, 6,   OCR↑, 2,   mt-OCR↑, 1,   OXPHOS↓, 5,   OXPHOS↑, 5,   mt-OXPHOS↓, 1,   mt-OXPHOS↑, 1,   PDH↓, 1,   PDH↑, 4,   PINK1↑, 1,   SIRT3↓, 3,   SIRT3↑, 3,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 6,   5LO↓, 5,   ACC↓, 1,   ACC↑, 3,   p‑ACC↑, 1,   ACLY↓, 2,   ACSL4↑, 2,   ALAT↓, 10,   ALDOA↓, 2,   AMP↓, 1,   AMP↑, 1,   AMPK?, 1,   AMPK↓, 3,   AMPK↑, 37,   AMPK↝, 1,   p‑AMPK↑, 2,   p‑AMT/GCST/T-protein↑, 1,   ATP↓, 40,   ATP↑, 1,   mt-ATP↓, 1,   CAIX/CA9↓, 4,   CholSyn↓, 1,   ECAR↓, 4,   ECAR↑, 1,   ECAR↝, 1,   ENO1↓, 3,   FABP4↓, 1,   FASN↓, 9,   G6PD↓, 2,   GAPDH↓, 2,   GLO-I↓, 2,   GLS↓, 2,   glucoNG↓, 1,   glucose↓, 1,   glucose↝, 1,   GlucoseCon↓, 18,   GlucoseCon∅, 1,   glut↓, 1,   GlutaM↓, 1,   GlutMet↓, 1,   Glycolysis↓, 51,   GSK‐3β↓, 15,   GSK‐3β↑, 9,   p‑GSK‐3β↓, 9,   H2S↑, 1,   Histones↑, 2,   HK1↓, 2,   HK2↓, 26,   HMG-CoA↓, 1,   IDH1↑, 1,   IDO1↓, 1,   lactateProd↓, 23,   lactateProd↑, 1,   lactateProd∅, 1,   LDHA↓, 17,   LDL↓, 4,   lipidLev↓, 1,   lipoGen↓, 1,   MCT4↓, 2,   NADPH↓, 4,   NADPH↑, 2,   PCK1↓, 1,   PDK1 / PDPK1?, 2,   PDK1 / PDPK1↓, 11,   PDK3↑, 1,   PDKs↓, 1,   PFK↓, 4,   PFK1↓, 1,   PGK1↓, 1,   PKM1↑, 1,   PKM2↓, 21,   PKM2↑, 1,   PKM2∅, 1,   PLA2↓, 1,   PPP↓, 2,   Pyrim↓, 1,   Pyruv↓, 1,   Pyruv↑, 1,   p‑S6↓, 2,   SCD1↓, 2,   SIRT1↓, 10,   SIRT1↑, 5,   SLC25A1↓, 1,   SREBF2↓, 1,   SREBP1/SREBF1↓, 2,   SREBP2↓, 1,   TCA↓, 2,   TCA↑, 1,   TS↓, 2,   Warburg↓, 10,  

Cell Death(tgid=5) ⓘ

AIF↑, 22,   APAF1↑, 11,   Apoptosis?, 2,   Apoptosis↓, 12,   Apoptosis↑, 657,   mt-Apoptosis↑, 11,   ASC↓, 1,   ASC↑, 1,   ASK1↑, 3,   p‑ASK1↑, 1,   BAD↓, 3,   BAD↑, 23,   p‑BAD↓, 1,   Bak↓, 1,   Bak↑, 14,   BAX↓, 6,   BAX↑, 251,   BAX↝, 3,   Bax:Bcl2↑, 67,   Bcl-2↓, 276,   Bcl-2↑, 8,   Bcl-2↝, 2,   Bcl-2∅, 1,   Bcl-xL↓, 70,   Bcl-xL↑, 1,   BID↓, 1,   BID↑, 12,   p‑BID↓, 1,   cl‑BID↑, 1,   BIM↑, 10,   BNIP3↑, 4,   BNIP3↝, 1,   BOK↑, 1,   BTG3↑, 1,   Casp↓, 4,   Casp↑, 73,   Casp↝, 2,   Casp∅, 1,   cl‑Casp↑, 3,   Casp1↓, 2,   Casp1↑, 3,   proCasp1↓, 1,   Casp10↓, 1,   Casp10↑, 3,   Casp12?, 1,   Casp12↑, 5,   cl‑Casp12↑, 2,   cl‑Casp12↝, 1,   Casp2↑, 2,   Casp3↓, 6,   Casp3↑, 295,   Casp3↝, 2,   cl‑Casp3↑, 65,   cl‑Casp3⇅, 1,   proCasp3↓, 3,   proCasp3↑, 3,   pro‑Casp3↑, 1,   CASP4↑, 1,   Casp6↓, 1,   Casp6↑, 3,   Casp7↑, 32,   cl‑Casp7↑, 7,   Casp8↓, 3,   Casp8↑, 66,   Casp8∅, 1,   cl‑Casp8↑, 11,   proCasp8↑, 3,   Casp9↓, 2,   Casp9↑, 171,   p‑Casp9↑, 1,   cl‑Casp9↑, 21,   proCasp9↓, 2,   proCasp9↑, 3,   cFLIP↓, 8,   Cyt‑c↓, 4,   Cyt‑c↑, 162,   Cyt‑c↝, 5,   mt-Cyt‑c↓, 1,   Diablo↑, 10,   DR5↓, 1,   DR5↑, 36,   Endon↑, 2,   FADD↑, 9,   Fap1↓, 1,   Fas↓, 1,   Fas↑, 34,   FasL↑, 18,   FasL⇅, 1,   Ferroptosis↑, 31,   GSDME↑, 1,   cl‑GSDME↑, 2,   HEY1↓, 1,   IAP1↓, 14,   IAP1↑, 1,   IAP2/BIRC3↓, 3,   IAP2/BIRC3↑, 1,   cl‑IAP2/BIRC3↑, 1,   ICAD↑, 1,   ICD↑, 1,   iNOS↓, 18,   iNOS↑, 1,   Mcl-1↓, 34,   Mcl-1↑, 1,   p‑Mcl-1↓, 1,   MDM2↓, 16,   MLKL↑, 2,   MOMP↓, 1,   MOMP↑, 8,   NAIP↓, 1,   Necroptosis↑, 6,   necrosis↑, 6,   NOXA↑, 6,   oncosis↑, 1,   P2X7↓, 1,   p38↓, 7,   p38↑, 31,   p‑p38↓, 5,   p‑p38↑, 7,   PUMA↓, 1,   PUMA↑, 10,   Pyro↑, 7,   RIP1↓, 2,   RIP3↑, 2,   p‑RIP3↑, 1,   survivin↓, 80,   TNFR 1↑, 2,   TRAIL↑, 6,   TRAILR↑, 2,   TumCD?, 1,   TumCD↓, 2,   TumCD↑, 61,   TUNEL↑, 2,   XIAP?, 1,   XIAP↓, 38,   XIAP↑, 1,   YAP/TEAD↓, 6,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 245,   Akt↑, 9,   Akt↝, 1,   p‑Akt↓, 69,   p‑Akt↑, 2,   AKT1↓, 6,   Akt2↓, 3,   AMPKα↑, 4,   BRAF↓, 1,   CaMKII ↓, 1,   CDC7↓, 1,   CIP2A↓, 1,   CK2↓, 7,   cMET↓, 3,   p‑cMET↑, 1,   CREB↓, 1,   cSrc↓, 2,   DDIT4↑, 1,   EF-1α↓, 1,   EGFR↓, 56,   EGFR↑, 1,   p‑EGFR↓, 6,   ERK↓, 67,   ERK↑, 18,   ERK↝, 2,   p‑ERK↓, 20,   p‑ERK↑, 7,   p‑ERK⇅, 1,   FGFR1↓, 4,   FGFR2↓, 1,   FOXD3↑, 1,   HCAR2↑, 1,   HER2/EBBR2↓, 23,   IGF-1R↓, 2,   IGFR↓, 3,   IKKα↓, 10,   p‑IKKα↓, 2,   IκB↓, 1,   IκB↑, 1,   p‑IκB↓, 2,   JAK↓, 7,   JAK1?, 1,   JAK1↓, 6,   JAK1↑, 1,   p‑JAK1↓, 2,   JAK2↓, 20,   p‑JAK2↓, 5,   p‑JAK3↓, 1,   JNK↓, 7,   JNK↑, 42,   JNK↝, 2,   p‑JNK↓, 4,   p‑JNK↑, 5,   LATS1↓, 1,   LIMK1↓, 1,   MAP2K1/MEK1↓, 1,   p‑MAP2K1/MEK1↓, 1,   MAPK?, 1,   MAPK↓, 57,   MAPK↑, 30,   MAPK↝, 4,   p‑MAPK↓, 2,   p‑MAPK↑, 2,   MARK4↓, 2,   MEK↓, 7,   p‑MEK↓, 2,   MKK4↓, 1,   MKP1↓, 1,   MKP2↓, 1,   Mst1↑, 1,   mTOR↓, 116,   mTOR↑, 3,   mTOR↝, 2,   p‑mTOR↓, 15,   mTORC2↓, 5,   p42↓, 1,   p70S6↓, 6,   p70S6↑, 1,   p‑p70S6↓, 1,   p‑p70S6↑, 1,   P70S6K↓, 7,   p‑P70S6K↓, 2,   p85S6K↓, 1,   P90RSK↓, 1,   p‑P90RSK↑, 1,   PDGFR-BB↓, 1,   PDGFRA↓, 1,   PDGFRB↓, 1,   PI3K↓, 176,   PI3K↑, 6,   PI3K↝, 2,   p‑PI3K↓, 8,   p‑PI3K↑, 1,   PI3K/Akt↓, 7,   PI3K/Akt↑, 1,   PI3k/Akt/mTOR↓, 6,   PIK3CA↓, 1,   PKA↓, 1,   PKCδ↓, 14,   PP2A↑, 1,   PRAS40↑, 1,   PRKCG↑, 1,   PTEN↓, 1,   PTEN↑, 33,   p‑PTEN↓, 1,   Raf↓, 5,   e-Raf↓, 1,   c-Raf↓, 1,   RAS↓, 17,   RET↓, 1,   RPS6KA1↓, 1,   p‑S6K↓, 1,   SHP1↓, 1,   SHP1↑, 3,   Sp1/3/4↓, 16,   Src↓, 1,   Src↑, 1,   STAT↓, 5,   STAT3↓, 120,   STAT3↑, 6,   STAT3↝, 1,   p‑STAT3↓, 28,   p‑STAT3↑, 2,   STAT5↓, 4,   STAT6↓, 4,   STK11/LKB1↑, 1,   p‑STK11/LKB1↑, 2,   THEM4/CTMP↑, 1,   TK1↓, 1,   TSC2↑, 4,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 2,   ATF2↓, 1,   ATF3↑, 2,   ATF4↓, 1,   ATF4↑, 19,   ATF4↝, 1,   p‑ATF4↝, 1,   ATFs↑, 1,   BRD4↓, 1,   CBP↓, 3,   CBP↑, 1,   ChrMod↑, 3,   ChrMod↝, 1,   cJun↓, 8,   cJun↑, 4,   p‑cJun↑, 1,   cMyc↓, 65,   cMyc↑, 2,   DNMT1↓, 15,   DNMT1↑, 1,   DNMT3A↓, 3,   DNMT3B↓, 2,   DNMTs↓, 11,   EZH2↓, 2,   FOXM1↓, 8,   FOXO↑, 1,   FOXO1↓, 2,   FOXO1↑, 3,   FOXO3↓, 8,   FOXO3↑, 8,   FOXO3↝, 1,   FOXO4↓, 2,   GATA3↓, 1,   H3↓, 2,   H3↑, 4,   p‑H3↓, 2,   p‑H3↑, 1,   ac‑H3↑, 10,   H3K27ac↓, 1,   H3K4↓, 1,   H4↑, 2,   ac‑H4↑, 7,   ac‑H4∅, 1,   HATs↓, 6,   HATs↑, 2,   HDAC↓, 48,   HDAC1↓, 9,   HDAC10↓, 1,   HDAC2↓, 7,   HDAC3↓, 7,   HDAC4↓, 2,   HDAC8↓, 4,   HMTs↓, 2,   JHDM1D-AS1↓, 1,   KLF4↓, 1,   miR-106b↓, 1,   miR-107↑, 2,   miR-122-5p↑, 1,   miR-126↑, 1,   miR-133a-3p↑, 1,   miR-134↑, 1,   miR-139-5p↑, 2,   miR-149↑, 1,   miR-155↓, 4,   miR-195↑, 1,   miR-199↓, 1,   miR-199↑, 1,   miR-19b↓, 1,   miR-203↓, 1,   miR-203↑, 1,   miR-206↑, 1,   miR-21↓, 8,   miR-21↑, 2,   miR-210↑, 1,   miR-215-5p↑, 1,   miR-218↑, 1,   miR-22↑, 1,   miR-221↑, 1,   miR-222↑, 1,   miR-224↓, 2,   miR-25-5p↓, 1,   miR-27a-3p↓, 2,   miR-29b↑, 1,   miR-30a-5p↑, 1,   miR-326-5p↑, 1,   miR-339-5p↑, 1,   miR-339-5p↝, 1,   miR-340↓, 2,   miR-34a↑, 11,   miR-34b-5p↑, 1,   miR-384↑, 1,   miR-422a↑, 2,   MTA2↓, 1,   Myc↓, 6,   Myc↑, 1,   MYCN↓, 1,   n-MYC↓, 2,   NDRG1↑, 1,   NNMT↓, 1,   OCT4↓, 16,   other?, 2,   other↓, 9,   other↑, 7,   other↝, 25,   other∅, 2,   OV6↓, 1,   PAX2↓, 1,   PCAF↓, 1,   PhotoS↑, 4,   PRC2↓, 1,   PRMT6↓, 1,   SBF2-AS1↓, 1,   Set9↑, 1,   sonoS↑, 1,   SOX2↓, 15,   SOX4↓, 4,   SOX4↑, 1,   SUV39H↓, 3,   TBX3↑, 1,   TCF-4↓, 2,   TFE3↑, 1,   tumCV?, 2,   tumCV↓, 152,   tumCV↑, 1,   tumCV∅, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 2,   cl‑ATF6↑, 1,   CHOP/DDIT3↑, 41,   p‑CHOP/DDIT3↝, 1,   cl‑CHOP/DDIT3↑, 1,   EDEM↑, 1,   eIF2α↓, 3,   eIF2α↑, 11,   p‑eIF2α↑, 6,   p‑eIF2α↝, 1,   ER Stress↓, 4,   ER Stress↑, 85,   ER Stress↝, 1,   ERStress↑, 1,   GRP78/BiP?, 1,   GRP78/BiP↓, 3,   GRP78/BiP↑, 19,   GRP94↑, 1,   HSF1↓, 2,   HSP27↓, 8,   HSP27↑, 3,   HSP27↝, 1,   HSP70/HSPA5↓, 8,   HSP70/HSPA5↑, 5,   HSP70/HSPA5↝, 1,   HSP90↓, 24,   HSP90↑, 2,   HSPs↓, 3,   IRE1↑, 4,   PDI↑, 1,   PERK↓, 1,   PERK↑, 12,   p‑PERK↑, 1,   p‑PERK↝, 1,   UPR↑, 16,   XBP-1↑, 2,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG13↑, 2,   ATG16L1↑, 1,   ATG3↑, 2,   ATG5↓, 1,   ATG5↑, 11,   ATG7↑, 2,   AVOs↑, 1,   Beclin-1/ATG6↓, 6,   Beclin-1/ATG6↑, 20,   CTSB↓, 2,   CTSD↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 4,   LC3A↑, 2,   LC3B↓, 1,   LC3B↑, 2,   LC3B-II↓, 1,   LC3B-II↑, 4,   LC3II↓, 2,   LC3II↑, 13,   LC3s↑, 2,   LC3s↝, 1,   MitoP↓, 1,   p62↓, 9,   p62↑, 7,   PARK2↑, 1,   RUBCN↓, 1,   SESN2↑, 4,   TumAuto↓, 4,   TumAuto↑, 84,   TumAuto⇅, 1,   TumAuto↝, 2,   ULK1/ATG1↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 11,   p‑ATM↑, 2,   ATR↑, 4,   p‑ATR↑, 1,   BRCA1↓, 1,   BRCA1↑, 3,   p‑BRCA1↑, 1,   BRCA2↓, 1,   BRCA2↑, 1,   CUL4B↑, 1,   DFF45↑, 2,   DNA-PK↑, 1,   DNAdam↓, 6,   DNAdam↑, 160,   mt-DNAdam↑, 1,   DNArepair↓, 8,   ERCC3↑, 1,   m-FAM72A↓, 1,   G9a↓, 2,   HR↓, 1,   hTERT/TERT↓, 17,   MDMX↓, 1,   MGMT↓, 2,   MSH2↑, 1,   NHEJ↓, 1,   p16↑, 7,   P53?, 1,   P53↓, 9,   P53↑, 213,   P53↝, 3,   p‑P53↓, 2,   p‑P53↑, 5,   ac‑P53↑, 1,   p53 Wildtype↓, 1,   p53 Wildtype∅, 1,   p73↑, 1,   PARP↓, 9,   PARP↑, 36,   PARP↝, 1,   p‑PARP↑, 1,   cl‑PARP↓, 2,   cl‑PARP↑, 143,   PARP1↓, 1,   PARP1↑, 5,   cl‑PARP1↑, 3,   PCNA↓, 48,   PCNA↑, 1,   PCNA↝, 1,   POLD1↓, 1,   RAD51↓, 1,   SIRT6↓, 3,   SIRT6↑, 1,   Telomerase↓, 15,   TOP1?, 1,   TOP1↓, 8,   TOP2↓, 7,   TP53↑, 4,   TRF2↓, 2,   UHRF1↓, 2,   XRCC1↓, 1,   γH2AX↑, 26,   γH2AX↝, 1,   p‑γH2AX↑, 3,  

Cell Cycle & Senescence(tgid=11) ⓘ

ANAPC2↑, 1,   AURKB↑, 1,   BRD4↓, 1,   CC(CDKs/cyclins)↓, 2,   CDK1↓, 45,   CDK1↑, 7,   CDK1↝, 1,   p‑CDK1↓, 1,   CDK1/2/5/9∅, 1,   CDK2↓, 90,   CDK2↑, 6,   p‑CDK2↓, 1,   CDK4↓, 114,   CDK4↑, 5,   p‑CDK4↓, 1,   CDK4/6↓, 3,   CDK6↓, 35,   CDK6↑, 6,   CDK8↓, 2,   CDKN1C/p57↓, 1,   CDKN1C/p57↑, 1,   CDKN2C/p18↑, 2,   cellSen↑, 2,   CHK1↓, 4,   CHK1↑, 4,   CHK1↝, 1,   p‑CHK1↑, 4,   Chk2↓, 2,   Chk2↑, 9,   p‑Chk2↑, 2,   ChrCon↑, 1,   Cyc↓, 8,   cycA1/CCNA1↓, 33,   cycA1/CCNA1↑, 5,   CycB/CCNB1↓, 74,   CycB/CCNB1↑, 10,   CycB/CCNB1↝, 1,   cycD1/CCND1↓, 220,   cycD1/CCND1↑, 6,   cycD1/CCND1↝, 1,   p‑cycD1/CCND1↓, 1,   CycD3↓, 4,   CycD3↑, 1,   cycE/CCNE↓, 63,   cycE/CCNE↑, 5,   cycE1↓, 4,   cycF↓, 1,   cycF↑, 1,   E2F4↑, 1,   E2Fs↓, 10,   FBXO5/EMI1↓, 1,   GADD45A↑, 5,   Ki-67↓, 49,   mitA↑, 4,   p19↑, 3,   P21?, 2,   P21↓, 10,   P21↑, 193,   P21↝, 1,   p27/CDKN1B↓, 7,   p27/CDKN1B↑, 75,   cl‑p27/CDKN1B↓, 1,   PLK1↓, 1,   pRB↓, 5,   pRB↑, 1,   p‑pRB↓, 7,   RB1↑, 6,   p‑RB1↓, 10,   cl‑RB1↓, 1,   Securin↓, 2,   TumCCA?, 8,   TumCCA↓, 29,   TumCCA↑, 1128,   TumCCA⇅, 1,   TumCCA∅, 1,   WEE1↑, 3,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

4E-BP1↓, 3,   p‑4E-BP1↓, 2,   ALDH↓, 5,   ALDH1A1↓, 4,   AXIN1↓, 1,   Axin2↓, 1,   Axin2↑, 1,   BMI1↓, 1,   BMP7/OP1↓, 3,   BMPs↑, 1,   CD133↓, 17,   CD24↓, 3,   CEBPA↑, 1,   cFos↓, 6,   cFos↑, 1,   cMYB↓, 3,   CSCs?, 1,   CSCs↓, 68,   CSCs↑, 1,   Diff↓, 1,   Diff↑, 7,   EIF4E↓, 2,   EP300↑, 1,   EP4/PTGER4↑, 1,   FGF↓, 4,   Gli1↓, 12,   HH?, 1,   HH↓, 12,   HMGCR↓, 3,   IGF-1?, 1,   IGF-1↓, 12,   IGF-1↑, 1,   p‑IGF-1↓, 1,   IGFBP3↑, 4,   IGFBP7↑, 1,   p‑Jun↓, 1,   Ki-67↓, 49,   Let-7↑, 5,   LGR5↓, 1,   mTORC1↓, 6,   p‑mTORC1↓, 1,   Nanog↓, 17,   Nestin↓, 3,   NF2↑, 1,   NKD2↑, 1,   NOTCH↓, 22,   NOTCH1↓, 17,   NOTCH1↑, 3,   NOTCH2↓, 1,   NOTCH3↓, 4,   OGFr↑, 1,   p300↓, 5,   PTCH1↓, 1,   SAL↑, 1,   SCF↓, 1,   Shh↓, 15,   Smo↓, 5,   Smo∅, 1,   STAT1↓, 1,   Sufu↑, 1,   TOPflash↓, 1,   TumCG?, 4,   TumCG↓, 244,   TumCG↑, 3,   TumCP?, 2,   TumCP↓, 396,   TumCP↑, 8,   tyrosinase↓, 2,   URGCP/URG4↓, 1,   Wnt↓, 60,   Wnt↝, 1,   Wnt/(β-catenin)↓, 15,   ZFX↓, 1,  

Migration(tgid=13) ⓘ

67LR↓, 1,   annexin II↓, 1,   AntiAg↓, 1,   AntiAg↑, 3,   AP-1↓, 17,   APC↑, 1,   ATPase↓, 2,   AXL↓, 1,   BACH1↓, 1,   CA↓, 2,   Ca+2↓, 3,   Ca+2↑, 57,   Ca+2↝, 4,   i-Ca+2↑, 4,   CAFs/TAFs↓, 1,   cal2↑, 2,   CCN2/CTGF↓, 2,   CD11b↑, 1,   Cdc42↑, 1,   Chl↑, 1,   Cofilin↓, 2,   COL1↓, 1,   COL1A1↓, 1,   COL3A1↓, 2,   E-cadherin↓, 12,   E-cadherin↑, 58,   E-cadherin↝, 1,   EMT?, 1,   EMT↓, 104,   EMT↑, 2,   EMT↝, 1,   EpCAM↓, 6,   F-actin↓, 2,   FAK↓, 19,   FAK↑, 1,   p‑FAK↓, 7,   p‑FAK↑, 1,   fascin↓, 1,   Fibronectin↓, 3,   GIT1↓, 1,   GLI2↓, 1,   ITGA5↓, 2,   ITGB1↓, 2,   ITGB1↑, 1,   ITGB4↓, 2,   KRAS↓, 2,   LAMs↓, 3,   LEF1↓, 3,   MALAT1↓, 1,   MET↓, 2,   MMP-10↓, 2,   MMP1↓, 8,   MMP13↓, 3,   MMP16↓, 2,   MMP2↓, 124,   MMP3↓, 10,   MMP7↓, 14,   MMP9↓, 152,   MMP9↑, 2,   MMP9:TIMP1↓, 1,   MMPs↓, 47,   MTA1↓, 1,   MUC1↓, 1,   MUC1-C↓, 1,   MUC4↓, 4,   N-cadherin?, 1,   N-cadherin↓, 36,   N-cadherin↑, 1,   N-cadherin↝, 1,   NCAM↓, 2,   NCAM↑, 1,   NEDD9↓, 2,   NFAT↑, 1,   p44↓, 1,   PAK1↓, 3,   pax↓, 1,   p‑pax↓, 1,   PCBP1↓, 1,   PDGF↓, 6,   Rac1↓, 1,   RECK↑, 1,   Rho↓, 3,   ROCK1↓, 7,   ROCK1↑, 1,   Slug?, 1,   Slug↓, 9,   Smad1↓, 1,   Smad1↑, 1,   Smad1↝, 1,   SMAD2↓, 4,   p‑SMAD2↓, 1,   SMAD3↓, 6,   SMAD3↑, 1,   p‑SMAD4↓, 1,   Snail?, 1,   Snail↓, 21,   STAC2↓, 1,   T-cadherin↑, 1,   TET1↓, 1,   TET1↑, 5,   TGF-β↓, 24,   TGF-β↑, 1,   TGF-β↝, 1,   TGF-β1↓, 1,   THBS1↓, 1,   THBS1↑, 1,   TIMP1↓, 2,   TIMP1↑, 11,   TIMP2↓, 3,   TIMP2↑, 12,   TPM4↓, 1,   pol-TregCell↓, 1,   TRIB3↑, 1,   Trop2↓, 1,   TSC1↑, 2,   TSP-1↑, 4,   TumCA↓, 1,   TumCI↓, 152,   TumCI↑, 2,   TumCMig?, 1,   TumCMig↓, 161,   TumCMig↑, 2,   TumMeta↓, 129,   TumMeta↑, 9,   Twist↓, 18,   TXNIP↑, 1,   uPA↓, 25,   uPAR↓, 4,   Vim?, 1,   Vim↓, 42,   Vim↑, 1,   Zeb1↓, 13,   ZEB2↓, 2,   α-SMA↓, 2,   α-tubulin↓, 4,   β-catenin/ZEB1↓, 74,   β-catenin/ZEB1↑, 3,   p‑β-catenin/ZEB1↓, 1,   cl‑β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 160,   angioG↑, 3,   CCN1/CYR61↓, 1,   CD31/PECAM-1↓, 5,   ECM/TCF↓, 1,   EGR1↓, 1,   Endoglin↑, 2,   eNOS↓, 3,   HIF-1↓, 10,   Hif1a↓, 90,   Hif1a↑, 2,   LOX1↓, 2,   NO↓, 6,   NO↑, 7,   VCAM-1↓, 3,   VEGF↓, 153,   VEGF↑, 1,   VEGFR1↓, 3,   VEGFR2/KDR/Flk1↓, 23,   p‑VEGFR2/KDR/Flk1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

AQPs↓, 1,   BBB↑, 7,   BBB∅, 1,   CellMemb↑, 1,   CLDN1↓, 2,   CLDN1↑, 1,   CLDN2↓, 2,   CTR1↑, 1,   EPR↑, 14,   GLUT1↓, 16,   GLUT2↓, 2,   GLUT4↓, 6,   IBI↑, 1,   memfluid↓, 1,   MMP?, 1,   MMP↓, 264,   MMP↑, 3,   MMP∅, 1,   MPT↑, 9,   NHE1↓, 2,   OATPs↓, 2,   OCLN↑, 1,   SLC12A5↓, 1,   SVCT-2∅, 1,   TJ↑, 1,   TRPM7↓, 3,   TRPM7↑, 1,   TRPV1↑, 4,   TRPV1↝, 1,   ZO-1↓, 1,   ZO-1↑, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

B2M↓, 1,   CB2 / CNR2↑, 3,   CCR7↓, 1,   CD155↓, 1,   CD25+↑, 1,   CD4+↓, 1,   CD4+↑, 4,   CD44↓, 20,   CD44↝, 1,   CD47↓, 1,   CD8+↑, 4,   cDC2↓, 8,   p‑cDC2↓, 2,   p‑cDC2↑, 1,   COX1↓, 2,   COX2/PTGS2↓, 109,   COX2/PTGS2↑, 4,   COX2/PTGS2↝, 2,   CXCL12↓, 2,   CXCL9↓, 1,   CXCR2↓, 2,   CXCR2↑, 1,   CXCR4↓, 13,   DCells↑, 2,   DR4↑, 9,   DR4∅, 1,   DR6↑, 1,   FOXP3↓, 1,   FOXP3↑, 2,   Gal-3↓, 2,   HCAR2↑, 1,   HMGB1↓, 5,   ICAM-1↓, 6,   IFN-γ↓, 6,   IFN-γ↑, 2,   Igs↑, 2,   IL1↓, 7,   IL1↑, 1,   IL10↓, 3,   IL10↑, 3,   IL12↑, 1,   IL13↓, 1,   IL17↓, 1,   IL1α↓, 1,   IL1β↓, 21,   IL1β↑, 1,   IL2↓, 3,   IL2↑, 4,   IL4↓, 1,   IL4↑, 1,   IL6↓, 53,   IL6↑, 1,   IL8↓, 12,   IL8↑, 1,   Imm↑, 28,   Imm↝, 3,   Inflam↓, 53,   Inflam↝, 1,   IRAK1↓, 1,   M2 MC↓, 1,   MCP1/CCL2↓, 3,   MCT1↓, 2,   MIP2↓, 1,   MyD88↑, 1,   NAF1↓, 1,   NF-kB?, 1,   NF-kB↓, 220,   NF-kB↑, 8,   NF-kB↝, 1,   p‑NF-kB↓, 2,   p‑NF-kB↑, 2,   NK cell↑, 11,   NLRP3↓, 3,   NLRP3↑, 2,   NOD1↓, 1,   p65↓, 9,   p65↑, 1,   p‑p65↓, 4,   ac‑p65↓, 1,   ac‑p65↑, 2,   PD-1↓, 2,   PD-L1↓, 12,   PD-L1↑, 3,   PGE2↓, 22,   PSA↓, 20,   PSA∅, 1,   RAGE↓, 2,   SOCS-3↓, 1,   SOCS-3↑, 1,   T-Cell↑, 2,   TCF↓, 4,   Th1 response?, 1,   Th1 response↑, 1,   TLR4↓, 5,   TLR4↑, 1,   TLR4↝, 1,   TNF-α↓, 41,   TNF-α↑, 8,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 4,   TRADD↑, 1,   Treg lymp↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

ADAM17↓, 1,   pH↓, 1,   i-pH↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   CAXII/CA12↑, 1,   PTN↓, 1,  

Protein Aggregation(tgid=19) ⓘ

APOE4↑, 1,   BACE/β-secretase↓, 1,   PSEN1/PS1↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

2/16-OHE1↑, 1,   4-OHE1↓, 1,   6IL↑, 1,   ACE/ACE1↓, 1,   AhR↓, 2,   AhR↑, 1,   AR↓, 22,   AR↑, 1,   COMT↓, 1,   ER-α36↓, 4,   ER(estro)↓, 2,   ER(estro)↑, 1,   ERα/ESR1↓, 3,   ERβ/ESR2↑, 1,   Estro↝, 1,   EstroRS/ERS↓, 1,   FGF21↓, 1,   GR↑, 1,   PPARγ↓, 2,   PPARγ↑, 9,   PRL↓, 1,   RANKL↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 3,   AKR1B10↓, 1,   BioAv↓, 63,   BioAv↑, 58,   BioAv↝, 12,   BioEnh↑, 6,   CBR1↓, 1,   chemoR↓, 1,   ChemoSen↓, 4,   ChemoSen↑, 271,   ChemoSen∅, 1,   CompStab?, 1,   CompStab↓, 1,   CompStab↑, 4,   CompStab↝, 1,   CYP1A1↓, 5,   CYP1A1↑, 3,   CYP1A2↓, 1,   CYP1B1↓, 1,   CYP3A4↓, 2,   DDS↑, 1,   Dose?, 5,   Dose↓, 3,   Dose↑, 10,   Dose⇅, 3,   Dose↝, 98,   Dose∅, 12,   eff↓, 110,   eff↑, 148,   eff↝, 17,   eff∅, 3,   GSTA1↓, 2,   GSTA1↑, 1,   GSTP1/GSTπ↓, 1,   Half-Life↓, 19,   Half-Life↑, 4,   Half-Life↝, 16,   Half-Life∅, 2,   MDR1↓, 13,   MRP1/ABCC1↓, 6,   NAT↓, 1,   P-gp/ABCB1↓, 31,   P-gp/ABCB1∅, 1,   P450↓, 5,   P450↝, 1,   RadioS?, 1,   RadioS↓, 1,   RadioS↑, 84,   RadioS↝, 1,   selectivity?, 4,   selectivity↓, 2,   selectivity↑, 190,   selectivity∅, 1,   Synergy↑, 136,  

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 1,   ALAT↓, 10,   ALP↓, 4,   AR↓, 22,   AR↑, 1,   AST↓, 7,   B2M↓, 1,   BRAF↓, 1,   BRCA1↓, 1,   BRCA1↑, 3,   p‑BRCA1↑, 1,   CEA↓, 1,   CRP↓, 2,   E6↓, 4,   E7↓, 3,   EGFR↓, 56,   EGFR↑, 1,   p‑EGFR↓, 6,   ERα/ESR1↓, 3,   EstroRS/ERS↓, 1,   EZH2↓, 2,   Ferritin↓, 2,   FOXM1↓, 8,   HER2/EBBR2↓, 23,   hTERT/TERT↓, 17,   IL6↓, 53,   IL6↑, 1,   KRAS↓, 2,   LDH↓, 9,   LDH↑, 6,   LDH↝, 3,   i-LDH↓, 1,   Maspin↑, 1,   Myc↓, 6,   Myc↑, 1,   PD-L1↓, 12,   PD-L1↑, 3,   PSA↓, 20,   PSA∅, 1,   RAGE↓, 2,   TP53↑, 4,   TRIB3↑, 1,   Tumccf↓, 1,   XIST↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiCan↓, 3,   AntiCan↑, 107,   AntiCan?, 1,   AntiDiabetic↑, 2,   antiNeop↑, 4,   AntiTum↓, 1,   AntiTum↑, 40,   Appetite↑, 1,   BowelM↑, 1,   breath↑, 1,   cachexia↓, 1,   cardioP↑, 13,   CardioT↓, 2,   CardioT↑, 2,   chemoP↑, 43,   chemoPv↑, 33,   ChemoSideEff↓, 6,   cognitive↑, 1,   fatigue↓, 1,   fatigue∅, 1,   FTO↑, 1,   hepatoP↓, 2,   hepatoP↑, 15,   hepatoP∅, 1,   K17↓, 1,   kidSt↓, 1,   memory↑, 1,   Mucositis↓, 1,   neuroP↑, 14,   NP/CIPN↓, 1,   Obesity↓, 1,   Obesity↑, 1,   OS?, 1,   OS↑, 26,   OS⇅, 1,   Pain↓, 4,   PFS↑, 1,   Pin1↓, 3,   QoL↑, 10,   QoL∅, 2,   radioP↑, 11,   Remission↑, 1,   RenoP↑, 8,   Risk↓, 25,   Sleep↑, 2,   Strength↑, 2,   TGFβR1↑, 1,   toxicity?, 1,   toxicity↓, 31,   toxicity↑, 6,   toxicity↝, 9,   toxicity∅, 5,   TumVol↓, 50,   TumVol↑, 2,   TumVol∅, 1,   TumW↓, 21,   TumW∅, 1,   Weight↑, 3,   Weight∅, 2,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↓, 1,   AntiFungal↑, 1,   AntiViral↑, 1,   Bacteria↓, 4,   Bacteria↑, 1,   GutMicro↑, 8,   GutMicro↝, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,   Ingr↝, 5,  
Total Targets: 1394

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx?, 1,   antiOx↓, 6,   antiOx↑, 126,   mt-antiOx↑, 1,   ARE↑, 2,   Catalase↑, 48,   Copper↓, 1,   GPx↓, 1,   GPx↑, 35,   GPx1↑, 1,   GPx4↑, 2,   GSH↑, 40,   GSR↑, 6,   GSSG↓, 1,   GSTs↑, 21,   H2O2↓, 3,   HDL↓, 1,   HDL↑, 4,   HNE↓, 1,   HO-1↓, 1,   HO-1↑, 21,   Iron↓, 2,   i-Iron↓, 1,   Keap1↓, 3,   Keap1↑, 1,   Keap1↝, 1,   lipid-P↓, 44,   MDA↓, 33,   MPO↓, 5,   NADH↓, 1,   NOX4↓, 1,   NQO1↑, 4,   Nrf1↑, 1,   NRF2↓, 1,   NRF2↑, 51,   Prx↑, 1,   RNS↓, 3,   ROS?, 2,   ROS↓, 117,   ROS↑, 8,   ROS↝, 1,   ROS∅, 4,   mt-ROS?, 1,   selenoP↑, 1,   SOD↓, 1,   SOD↑, 51,   SOD1↑, 3,   SOD2↑, 1,   TAC↑, 6,   TBARS↓, 3,   Trx1↑, 1,   uricA↓, 2,   VitC↑, 2,   xCT/SLC7A11↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↓, 1,   IronCh↑, 4,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

DRP1/DNM1L↓, 1,   HSP60/HSPD1↓, 1,   Insulin↓, 1,   Insulin↑, 2,   MFN2↑, 1,   mitResp↑, 1,   OCR↑, 1,   PGC-1α↑, 1,   PGC-1α↝, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

15-LOX/ALOX15↓, 1,   5LO↓, 4,   ALAT↓, 12,   AMPK↑, 9,   p‑AMPK↑, 1,   ATP↑, 4,   CRM↑, 1,   DGAT1↓, 1,   ECAR↓, 1,   ECAR∅, 1,   FASN↓, 2,   glucose↓, 6,   glucose↝, 1,   GlucoseCon↑, 2,   glyC↓, 1,   Glycolysis↓, 1,   Glycolysis↑, 1,   GSK‐3β↓, 4,   GSK‐3β↑, 2,   H2S↑, 2,   HK2↑, 1,   LDHA↑, 1,   LDL↓, 6,   lipidLev↓, 2,   NADPH↑, 2,   SIRT1↑, 4,   SIRT1↝, 1,  

Cell Death(tgid=5) ⓘ

AIF↓, 1,   AIF↑, 1,   Apoptosis↓, 6,   Apoptosis↑, 1,   ASC↓, 1,   BAX↓, 8,   BAX↑, 1,   Bax:Bcl2↑, 2,   Bcl-2↓, 1,   Bcl-2↑, 4,   Casp↓, 1,   Casp1↓, 1,   Casp3?, 1,   Casp3↓, 11,   Casp3↑, 2,   cl‑Casp3↑, 1,   Casp8↑, 1,   cl‑Casp8↑, 2,   Casp9↓, 3,   Casp9↑, 1,   cl‑Casp9↑, 1,   Cyt‑c↓, 4,   Cyt‑c↑, 1,   Fas↓, 2,   Fas↑, 2,   FasL↓, 1,   Ferroptosis↓, 3,   IAP1↓, 1,   iNOS↓, 18,   iNOS↑, 1,   necrosis↓, 1,   p38↓, 1,   p38↑, 1,   survivin↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 4,   Akt↑, 3,   Akt↝, 1,   p‑Akt↑, 1,   p‑CREB↑, 1,   ERK↓, 2,   ERK↑, 2,   p‑ERK↑, 1,   IκB?, 1,   JAK↓, 1,   JNK↓, 3,   JNK↑, 3,   MAPK↓, 8,   MAPK↑, 1,   mTOR↓, 3,   mTOR↑, 2,   PDGFR-BB↓, 1,   PDGFRB↓, 1,   PI3K↓, 6,   PI3K↑, 2,   PKCδ↓, 1,   PTEN↑, 1,   STAT↓, 3,   STAT3↓, 2,   STAT3↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 5,   ATF2↑, 1,   cJun↓, 1,   cMyc↓, 1,   p‑cMyc↑, 1,   FOXO3↑, 1,   HDAC↓, 1,   HDAC3↓, 1,   other?, 1,   other↓, 2,   other↑, 5,   other↝, 7,   RUNX2↑, 1,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 1,   cl‑eIF2α↑, 1,   GRP78/BiP↑, 1,   HSP27↓, 1,   HSP70/HSPA5↓, 1,   HSP70/HSPA5↑, 3,   HSPs↑, 1,   p‑PERK↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 2,   Beclin-1/ATG6↑, 1,   LC3II↑, 1,   p62↑, 2,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 5,   DNArepair↑, 1,   p16↓, 1,   P53↓, 3,   P53↑, 4,   PARP↑, 1,   cl‑PARP↑, 2,   PARP1↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1,   CDK2↓, 1,   cycA1/CCNA1↓, 1,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 2,   cycE/CCNE↑, 1,   Ki-67↓, 1,   P21↓, 3,   P21↑, 5,   TumCCA↑, 9,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMP2↑, 1,   Diff↑, 1,   Diff↝, 1,   HH↓, 1,   IGF-1↓, 1,   IGFBP3↑, 1,   Ki-67↓, 1,   neuroG↑, 1,   TumCP↓, 2,   Wnt↑, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 12,   AP-1↓, 3,   BACH1↓, 1,   Ca+2↓, 2,   Ca+2↑, 1,   Ca+2↝, 1,   Cartilage↑, 1,   COL1↑, 1,   FAK↑, 1,   LAMs↑, 1,   LRP1↑, 1,   MMP13↓, 2,   MMP9↓, 5,   MUC1↑, 1,   Smad1↑, 1,   TGF-β↓, 4,   TIMP1↓, 1,   TregCell↑, 1,   TumCI↓, 1,   TumCI∅, 1,   TumCMig∅, 1,   α-SMA↓, 1,   β-catenin/ZEB1↑, 1,   β-catenin/ZEB1↝, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 2,   angioG↑, 1,   E-sel↓, 1,   Hif1a↓, 2,   NO↓, 10,   NO↑, 1,   VCAM-1↓, 3,   VEGF↓, 3,   VEGF↑, 2,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 9,   BBB↝, 2,   GastroP↑, 6,   GLUT4↑, 2,   H+/K+-ATPase↓, 1,   IBI↑, 3,   MMP↓, 3,   MMP↑, 9,   MMP∅, 1,   MUC5AC↓, 1,   TRPA1↑, 1,   TRPC1↓, 1,   TRPM7↓, 1,   TRPV1↑, 1,   VGSC↓, 1,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CCL11↓, 1,   CD19↑, 1,   CD4+↑, 2,   CD8+↑, 1,   COX1↓, 4,   COX2/PTGS2↓, 35,   COX2/PTGS2↑, 1,   CXCR4↓, 1,   HMGB1↓, 1,   ICAM-1↓, 2,   IFN-γ↓, 3,   IFN-γ↑, 2,   IL1↓, 2,   IL10↓, 3,   IL10↑, 5,   IL12↓, 1,   IL17↓, 5,   IL18↓, 3,   IL1β↓, 21,   IL2↓, 1,   IL2↑, 1,   IL22↓, 1,   IL23↓, 1,   IL5↓, 1,   IL6?, 1,   IL6↓, 29,   IL6↑, 1,   IL8↓, 8,   Imm↑, 6,   Imm⇅, 2,   Inflam?, 1,   Inflam↓, 121,   Inflam↑, 4,   IRF3↓, 2,   pol-M2 MC↑, 1,   MCP1/CCL2↓, 2,   MyD88↓, 2,   NeuroI↓, 1,   NF-kB?, 1,   NF-kB↓, 41,   NF-kB↑, 1,   NK cell↑, 1,   NLRP3↓, 5,   NLRP3↑, 1,   PGE2↓, 15,   PGE2↑, 1,   RAGE↓, 2,   SOCS-3↓, 1,   TLR2↓, 3,   TLR4↓, 7,   TNF-α?, 1,   TNF-α↓, 37,   TNF-α↑, 2,   TRIF↓, 1,   β-HEX↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 2,   5HT↑, 2,   AChE↓, 17,   AChE↑, 1,   BChE↓, 3,   BDNF↑, 10,   GABA↑, 3,   GABA↝, 1,   MAOA↓, 2,   NGF↑, 3,   TPH1↓, 1,   TrkB↑, 2,   β-Endo↑, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 5,   Aβ↓, 19,   BACE/β-secretase↓, 6,   tau↓, 4,   p‑tau↓, 3,   XO↓, 2,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 1,   ACE2↓, 1,   AHR↓, 1,   CYP19↓, 1,   GPER↑, 1,   GR↑, 1,   PPARα↝, 1,   PPARγ↓, 2,   PPARγ↑, 2,   p‑PPARγ↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv?, 1,   BioAv↓, 50,   BioAv↑, 45,   BioAv↝, 22,   BioEnh↑, 2,   ChemoSen↑, 1,   CompStab↑, 1,   CompStab↝, 2,   CYP1A1↑, 1,   CYP1A2↑, 1,   CYP2D6↓, 1,   CYP2E1↓, 1,   Dose↑, 1,   Dose⇅, 1,   Dose↝, 10,   eff↓, 1,   eff↑, 11,   eff↝, 2,   GSTA1↓, 1,   GSTA1↑, 2,   Half-Life↓, 3,   Half-Life↑, 2,   Half-Life↝, 11,   Half-Life∅, 2,   P450↓, 3,   Synergy↑, 13,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 12,   ALP↓, 4,   AST↓, 15,   BloodF↑, 1,   BMD↑, 5,   BP↓, 9,   creat↓, 4,   CRP↓, 3,   HOMA↓, 1,   hs-CRP↓, 1,   IL6?, 1,   IL6↓, 29,   IL6↑, 1,   IRes↑, 1,   IRes↝, 1,   LDH↓, 7,   NOS2↓, 1,   RAGE↓, 2,   TC↓, 2,   TG/TAG↓, 2,   Urea↓, 1,   VLDL↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 7,   antiAll↑, 18,   AntiArt↑, 9,   AntiCan↓, 2,   AntiCan↑, 25,   antiCG↑, 1,   AntiDiabetic↓, 2,   AntiDiabetic↑, 31,   antiNeop↑, 2,   antiPs↑, 1,   AntiTum↓, 2,   AntiTum↑, 3,   Bone Healing↑, 1,   cardioP?, 1,   cardioP↓, 1,   cardioP↑, 53,   CardioT↓, 1,   chemoP↑, 10,   chemoPv↑, 7,   cognitive↑, 17,   cough?, 1,   diuretic↑, 1,   hepatoP↑, 43,   Learn↑, 1,   memory↑, 19,   motorD↑, 3,   Mucositis↓, 1,   neuroP↓, 1,   neuroP↑, 82,   Obesity↓, 15,   OS↑, 1,   Pain↓, 9,   radioP↑, 4,   RenoP↓, 1,   RenoP↑, 12,   Risk↓, 1,   SoreThr?, 1,   Stress↓, 2,   Stroke↓, 11,   toxicity?, 2,   toxicity↓, 56,   toxicity↑, 6,   toxicity↝, 11,   toxicity∅, 10,   Wound Healing↑, 4,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 17,   AntiFungal↓, 2,   AntiFungal↑, 7,   AntiP↓, 1,   AntiP↑, 4,   AntiViral↑, 13,   Bacteria↓, 28,   Diar↓, 3,   GutMicro↑, 15,   Sepsis↓, 2,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↑, 1,   Ingr↝, 6,  
Total Targets: 443

Scientific Paper Hit Count for: TumCCA, Tumor cell cycle arrest
41 Curcumin
31 Quercetin
30 Silver-NanoParticles
26 Sulforaphane (mainly Broccoli)
25 Thymoquinone
23 Apigenin (mainly Parsley)
22 Berberine
21 Fisetin
21 Kaempferol
18 Radiotherapy/Radiation
18 Magnolol
17 Phenethyl isothiocyanate
16 Baicalein
16 Emodin
15 Artemisinin
15 Capsaicin
15 Piperlongumine
14 Magnetic Fields
14 Luteolin
14 Shikonin
13 Cisplatin
13 doxorubicin
13 EGCG (Epigallocatechin Gallate)
13 Chrysin
13 Garcinol
13 Lycopene
13 Resveratrol
12 Ashwagandha(Withaferin A)
12 Betulinic acid
12 Eugenol
12 Cucurbitacin
12 Honokiol
12 Licorice
11 Graviola
11 Licochalcone A
11 Linalool
10 Propolis -bee glue
9 5-fluorouracil
9 Rosmarinic acid
9 Ellagic acid
9 Formononetin
9 phytic acid, Inositol hexakisphosphate
9 Ivermectin
9 mebendazole
9 Silymarin (Milk Thistle) silibinin
9 Urolithin
8 Allicin (mainly Garlic)
8 Carvacrol
8 Crocetin
8 Diindolylmethane
8 Indole-3-carbinol
8 Ferulic acid
8 Paclitaxel/Taxol
8 Gallic acid
8 Ginkgetin
8 HydroxyTyrosol
7 Chemotherapy
7 Melatonin
7 chitosan
7 Evodiamine
7 Fucoidan
7 Juglone
7 Phenylbutyrate
7 Pterostilbene
6 Astaxanthin
6 Berbamine
6 Boswellia (frankincense)
6 Celastrol
6 chaetocin
6 Gambogic Acid
6 itraconazole
6 Matrine
6 Morin
6 Naringin
6 Selenite (Sodium)
5 Coenzyme Q10
5 Beta-Caryophyllene
5 Bufalin/Huachansu
5 Boron
5 Caffeic Acid Phenethyl Ester (CAPE)
5 Centella asiatica / Gotu kola → asiaticoside
5 Chlorogenic acid
5 Carvone
5 Cynaropicrin
5 Dandelion Root
5 Eurycomanone
5 Fenbendazole
5 Genistein (soy isoflavone)
5 isoorientin
5 Laetrile B17 Amygdalin
5 lambertianic acid
5 methylseleninic acid
5 Methylsulfonylmethane
5 Nimbolide
5 Plumbagin
5 salinomycin
5 Ursolic acid
5 Vitamin K2
4 1,8-Cineole
4 Vitamin C (Ascorbic Acid)
4 D-limonene
4 Brucea javanica
4 Caffeic acid
4 Thymol-Thymus vulgaris
4 Selenium
4 Cinnamon
4 Hydroxycinnamic-acid
4 Deguelin
4 Hyperoside
4 Lemongrass Extract/Citral
4 Methyl Jasmonate
4 Magnetic Field Rotating
4 Moringa oleifera
4 Marjoram (Origanum majorana)
4 VitK3,menadione
4 α-Santalol/Sandalwood oil
4 Selenium NanoParticles
4 Aflavin-3,3′-digallate
3 Astragalus
3 Copper and Cu NanoParticles
3 Alpha-Lipoic-Acid
3 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
3 Andrographis
3 Gemcitabine (Gemzar)
3 Anethole/trans-Anethole
3 Fennel Oil/Foeniculum vulgare
3 Isovitexin
3 Biochanin A
3 borneol
3 Bruteridin(bergamot juice)
3 Carnosic acid
3 Celecoxib
3 Cynara scolymus/Globe Artichoke/Artichoke Extract
3 Date Fruit Extract
3 diet Methionine-Restricted Diet
3 Piperine
3 Flaxseed/Linseed
3 SDG/lignans
3 Ginger/6-Shogaol/Gingerol
3 Hibiscus sabdariffa
3 Hyperthermia
3 Inositol
3 Isoliquiritigenin
3 Lasiodin
3 Metformin
3 Magnesium
3 Propyl gallate
3 Parthenolide
2 Gold NanoParticles
2 Photodynamic Therapy
2 Glucose
2 tamoxifen
2 DTS(dibenzyl trisulphide) from Anamu
2 Ascorbyl Palmitate
2 Atorvastatin
2 beta-glucans
2 Baicalin
2 Bacopa monnieri
2 α-Bisabolol / Chamomile oil
2 Butyrate
2 Zinc
2 NTP, Non-Thermal Plasma,Cold Atmospheric Plasma
2 Chlorophyllin
2 Docetaxel
2 Dihydrocaffeic Acid
2 Cyclopamine
2 Dichloroacetate
2 Diclofenac
2 Echinacea
2 Electrical Pulses
2 Flaxseed Oil
2 carboplatin
2 Geraniol
2 isoflavones
2 isoquercitrin
2 Vitexin
2 Lactoferrin/Talactoferrin
2 Lutein
2 Methylene blue
2 Modified Citrus Pectin
2 Lemon Balm/Melissa officinalis
2 Mucuna pruriens/Velvet Bean
2 Mistletoe/Viscum album Extracts
2 Mushroom Chaga, Inonotus obliquus
2 Mushroom Lion’s Mane, Hericium erinaceus
2 Oleuropein
2 Rauwolfia serpentina/Indian Snakeroot
2 Rutin
2 Terpinen-4-ol / Tea Tree Oil
1 3-bromopyruvate
1 Ajoene (compound of Garlic)
1 alpha Linolenic acid
1 Arctigenin
1 Aloe anthraquinones
1 immunotherapy
1 epirubicin
1 brusatol
1 Bromelain
1 Carnosine
1 Selenate
1 Chocolate
1 Vitamin E
1 Polyphenols
1 Docosahexaenoic Acid
1 diet FMD Fasting Mimicking Diet
1 Dipyridamole
1 Disulfiram
1 Cannabichromene
1 Citric Acid
1 Sorafenib (brand name Nexavar)
1 flavonoids
1 Arsenic trioxide
1 Vitamin A, Retinoic Acid
1 Shilajit/Fulvic Acid
1 Galloflavin
1 Ginkgolic acids
1 Ginkgo biloba
1 Germanium inorganic
1 Ginkgolide B
1 Ginseng
1 HydroxyCitric Acid
1 Rapamycin
1 High-Ozonide Oil
1 Isobavachalcone
1 iodine
1 Inulin Prebiotic
1 Recombinant Methioninase
1 Lactobacillus
1 Lapachol
1 low dose naltrexone
1 Mung Bean Sprouts
1 Dordaviprone; Modeyso
1 MCT, metronomic chemo
1 Methylglyoxal
1 Myricetin
1 Niclosamide (Niclocide)
1 Proanthocyanidins
1 Purple Corn / Purple Maize
1 Sanguinarine
1 Psoralidin
1 Rhein
1 buckwheat sprouts
1 Oxaliplatin
1 Sulfasalazine
1 Auranofin
1 Salvia miltiorrhiza
1 Spermidine
1 Osimertinib
1 Adagrasib
1 Turmerones
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:322  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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