Akt Cancer Research Results

Akt, PKB-Protein kinase B: Click to Expand ⟱

Source: HalifaxProj(inhibit)

Type:

Akt1 is involved in cellular survival pathways, by inhibiting apoptotic processes; Akt2 is an important signaling molecule in the insulin signaling pathway. It is required to induce glucose transport.

Inhibitors:
-Curcumin: downregulate AKT phosphorylation and signaling.
-Resveratrol
-Quercetin: inhibit the PI3K/AKT pathway.
-Epigallocatechin Gallate (EGCG)
-Luteolin and Apigenin: inhibit AKT phosphorylation

Scientific Papers found: Click to Expand⟱

1214-

VitK2,

Vitamin K2 promotes PI3K/AKT/HIF-1α-mediated glycolysis that leads to AMPK-dependent autophagic cell death in bladder cancer cells

-

in-vitro,

Bladder,

T24/HTB-9

50 μM

-

in-vitro,

Bladder,

J82

Glycolysis↑, GlucoseCon↑, lactateProd↑, TCA↓, PI3K↑, Akt↑, AMPK↑, mTORC1↓, TumAuto↑, GLUT1↑, HK2↑, LDHA↑, ACC↓, PDH↓, eff↓, cMyc↓, Hif1a↑, p‑Akt↑, eff↓, eff↓, eff↓, eff↓, ROS↑,

2283-

VitK2,

Vitamin K Contribution to DNA Damage—Advantage or Disadvantage? A Human Health Response

-

Review,

Var,

NA

*ER Stress↓, *toxicity↓, *toxicity↑, ROS↑, PI3K↑, Akt↑, Hif1a↑, GlucoseCon↑, lactateProd↑, ChemoSen↑, eff↑, eff↑,

2281-

VitK2,

The biological responses of vitamin K2: A comprehensive review

-

Review,

Var,

NA

*ROS↓, *12LOX↓, *NF-kB↓, *BMD↑, *hepatoP↑, cycD1/CCND1↓, PKCδ↓, STAT3↓, ERK↑, MAPK↓, ROS↑, PI3K↝, Akt↝, Hif1a↝, *neuroP↑,

7921-

VT,

Vitexin's Role in Colon Cancer Apoptosis: AMPK/mTOR Pathway Modulation Explored Through Experimental and Computational Approaches

-

in-vitro,

Colon,

Caco-2

Dose↝, tumCV↓, SOD↓, Catalase↓, MDA↑, P53↑, BAX↓, TSC2↑, SESN2↑, PUMA↑, AMPK↑, PI3K↑, Akt↑, mTOR↓,

7914-

VT,

Vitexin induces apoptosis through mitochondrial pathway and PI3K/Akt/mTOR signaling in human non-small cell lung cancer A549 cells

-

vitro+vivo,

Lung,

A549

tumCV↓, selectivity↑, Cyt‑c↑, MMP↓, p‑PI3K↓, p‑Akt↓, p‑mTOR↓, TumCG↓, mtDam↑, LDH↑, Bax:Bcl2↑, cl‑Casp3↑,

7909-

VT,

Vitexin Inhibits Gastric Cancer Growth and Metastasis through HMGB1-mediated Inactivation of the PI3K/AKT/mTOR/HIF-1α Signaling Pathway

-

vitro+vivo,

GC,

NA

mice

tumCV↓, TumCMig↓, TumCI↓, EMT↓, PI3K↓, Akt↓, Hif1a↓, HMGB1↓, TumCG?,

7887-

VT,

IVT,

Dietary Flavonoids Vitexin and Isovitexin: New Insights into Their Functional Roles in Human Health and Disease Prevention

-

Review,

AD,

NA

-

Review,

Var,

NA

*antiOx↑, *Inflam↓, *AntiCan↑, *Bacteria↓, *neuroP↑, *Obesity↓, *cardioP↑, *ROS↓, *MMP↑, *ATP↑, *MFN2↑, *DRP1/DNM1L↓, *FOXO3↑, *NRF2↑, *Ferroptosis↓, *GPx4↑, TumCP↓, HMGB1↓, PI3K↓, Akt↓, Hif1a↓, CDK1↓, CycB/CCNB1↓, TumCCA↑, Apoptosis↑, P53↑, NF-kB↓, ERK↓, p‑PI3K↓, miR-34a↑, Apoptosis↑, CSCs?, *MAPK↓, *HO-1↑, *hepatoP↑, *AMPK↑, *Akt↑, *GSK‐3β↑, *chemoP↑, *Casp3↓, *IRes↝, *GlucoseCon↑, ChemoSen↑, *GSH↑, *SOD↑, *ATF2↑, *GPx↑, *GSTs↑, *AntiAge↑, *Stroke↓, *AChE↓, *ACE/ACE1↓, *ACE2↓, *GutMicro↑, *MPO↓, *H+/K+-ATPase↓, *AntiDiabetic↑, *GLUT4↑, *Obesity↓, *HH↓, *RenoP↑, *BioAv↓, *BioAv↝, *BioAv↑,

2301-

Wog,

Flavonoids Targeting HIF-1: Implications on Cancer Metabolism

-

Review,

Var,

NA

HK2↓, PDK1↓, LDHA↓, Hif1a↓, PI3K↓, Akt↓, Glycolysis↓, P53↑, GLUT1↓,

1222-

Z,

Zinc regulates primary ovarian tumor growth and metastasis through the epithelial to mesenchymal transition

-

in-vitro,

Ovarian,

NA

EMT↑, TumCMig↑, TumCI↑, ERK↑, Akt↑,

2425-

γ-Toc,

Anticancer Effects of γ-Tocotrienol Are Associated with a Suppression in Aerobic Glycolysis

-

in-vitro,

NA,

MCF7

 6–8 µM

-

in-vivo,

NA,

NA

mouse

TumCG↓, GlucoseCon↓, ATP↓, lactateProd↓, Glycolysis↓, HK2↓, PFK↓, PKM2↓, LDHA↓, Akt↓, p‑mTOR↓, cMyc↓,

Showing Research Papers: 801 to 810 of 810
Prev Page 17 of 17

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 810

Pathway results for Effect on Cancer / Diseased Cells:

Redox & Oxidative Stress(tgid=1) ⓘ

Catalase↓, 1, MDA↑, 1, ROS↑, 3, SOD↓, 1,

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↓, 1, MMP↓, 1, mtDam↑, 1,

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACC↓, 1, AMPK↑, 2, cMyc↓, 2, GlucoseCon↓, 1, GlucoseCon↑, 2, Glycolysis↓, 2, Glycolysis↑, 1, HK2↓, 2, HK2↑, 1, lactateProd↓, 1, lactateProd↑, 2, LDH↑, 1, LDHA↓, 2, LDHA↑, 1, PDH↓, 1, PDK1↓, 1, PFK↓, 1, PKM2↓, 1, TCA↓, 1,

Cell Death(tgid=5) ⓘ

Akt↓, 4, Akt↑, 4, Akt↝, 1, p‑Akt↓, 1, p‑Akt↑, 1, Apoptosis↑, 2, BAX↓, 1, Bax:Bcl2↑, 1, cl‑Casp3↑, 1, Cyt‑c↑, 1, MAPK↓, 1, PUMA↑, 1,

Kinase & Signal Transduction(tgid=6) ⓘ

Transcription & Epigenetics(tgid=7) ⓘ

Autophagy & Lysosomes(tgid=9) ⓘ

SESN2↑, 1, TumAuto↑, 1,

DNA Damage & Repair(tgid=10) ⓘ

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1, CycB/CCNB1↓, 1, cycD1/CCND1↓, 1, TumCCA↑, 1,

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CSCs?, 1, EMT↓, 1, EMT↑, 1, ERK↓, 1, ERK↑, 2, miR-34a↑, 1, mTOR↓, 1, p‑mTOR↓, 2, mTORC1↓, 1, PI3K↓, 3, PI3K↑, 3, PI3K↝, 1, p‑PI3K↓, 2, STAT3↓, 1, TumCG?, 1, TumCG↓, 2,

Migration(tgid=13) ⓘ

PKCδ↓, 1, TumCI↓, 1, TumCI↑, 1, TumCMig↓, 1, TumCMig↑, 1, TumCP↓, 1,

Angiogenesis & Vasculature(tgid=14) ⓘ

Hif1a↓, 3, Hif1a↑, 2, Hif1a↝, 1,

Barriers & Transport(tgid=15) ⓘ

GLUT1↓, 1, GLUT1↑, 1,

Immune & Inflammatory Signaling(tgid=16) ⓘ

HMGB1↓, 2, NF-kB↓, 1,

Drug Metabolism & Resistance(tgid=21) ⓘ

ChemoSen↑, 2, Dose↝, 1, eff↓, 5, eff↑, 2, selectivity↑, 1,

Clinical Biomarkers(tgid=22) ⓘ

LDH↑, 1,
Total Targets: 82

Pathway results for Effect on Normal Cells:

NA, unassigned(tgid=0) ⓘ

ACE/ACE1↓, 1, ACE2↓, 1, H+/K+-ATPase↓, 1, IRes↝, 1, Stroke↓, 1,

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1, Ferroptosis↓, 1, GPx↑, 1, GPx4↑, 1, GSH↑, 1, GSTs↑, 1, HO-1↑, 1, MFN2↑, 1, MPO↓, 1, NRF2↑, 1, ROS↓, 2, SOD↑, 1,

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↑, 1, DRP1/DNM1L↓, 1, MMP↑, 1,

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1, AMPK↑, 1, GlucoseCon↑, 1,

Cell Death(tgid=5) ⓘ

Akt↑, 1, ATF2↑, 1, Casp3↓, 1, Ferroptosis↓, 1, MAPK↓, 1,

Protein Folding & ER Stress(tgid=8) ⓘ

ER Stress↓, 1,

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

FOXO3↑, 1, GSK‐3β↑, 1, HH↓, 1,

Barriers & Transport(tgid=15) ⓘ

Immune & Inflammatory Signaling(tgid=16) ⓘ

Inflam↓, 1, NF-kB↓, 1,

Synaptic & Neurotransmission(tgid=18) ⓘ

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1, BioAv↑, 1, BioAv↝, 1,

Clinical Biomarkers(tgid=22) ⓘ

BMD↑, 1, GutMicro↑, 1,

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1, AntiCan↑, 1, AntiDiabetic↑, 1, cardioP↑, 1, chemoP↑, 1, hepatoP↑, 2, neuroP↑, 2, Obesity↓, 2, RenoP↑, 1, toxicity↓, 1, toxicity↑, 1,

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 1,
Total Targets: 53

Scientific Paper Hit Count for: Akt, PKB-Protein kinase B

39 Curcumin
28 Quercetin
25 Thymoquinone
25 Apigenin (mainly Parsley)
22 Fisetin
21 Baicalein
20 Resveratrol
16 Berberine
16 Chrysin
14 Shikonin
13 Alpha-Lipoic-Acid
12 Emodin
12 Sulforaphane (mainly Broccoli)
11 Magnetic Fields
11 Formononetin
11 Lycopene
10 Ashwagandha(Withaferin A)
10 Eugenol
10 Honokiol
9 Carvacrol
9 EGCG (Epigallocatechin Gallate)
9 HydroxyTyrosol
9 Isobavachalcone
9 Inositol
9 Magnolol
8 5-fluorouracil
8 Silver-NanoParticles
8 Cisplatin
8 Artemisinin
8 Beta-Caryophyllene
8 Rosmarinic acid
8 Capsaicin
8 Deguelin
8 Ellagic acid
8 Garcinol
8 Hyperoside
8 IP6 (Inositol 1,2,3,4,5,6-hexakisphosphate)
8 isoorientin
8 Piperlongumine
8 Urolithin
7 Isovitexin
7 Propolis -bee glue
7 Cinnamon
7 Citric Acid
7 Radiotherapy/Radiation
7 Gambogic Acid
7 Indole-3-carbinol
7 Nimbolide
7 Phenethyl isothiocyanate
7 Silymarin (Milk Thistle) silibinin
6 Celastrol
6 Dandelion Root
6 Ferulic acid
6 Fucoidan
6 Gallic acid
6 Isoliquiritigenin
6 Vitexin
6 Luteolin
5 Allicin (mainly Garlic)
5 Anethole/trans-Anethole
5 Carnosic acid
5 Chlorogenic acid
5 Ursolic acid
5 Ginkgolide B
5 Ginseng
5 Naringin
5 Piperine
5 Selenite (Sodium)
4 Coenzyme Q10
4 Astragalus
4 Chemotherapy
4 brusatol
4 Boswellia (frankincense)
4 α-Bisabolol / Chamomile oil
4 Caffeic acid
4 Celecoxib
4 Ginkgetin
4 Hydrogen Gas
4 Hibiscus sabdariffa
4 Juglone
4 Magnetic Field Rotating
4 Vitamin K2
3 1,8-Cineole
3 3-bromopyruvate
3 doxorubicin
3 Gemcitabine (Gemzar)
3 Paclitaxel/Taxol
3 Astaxanthin
3 Baicalin
3 Betulinic acid
3 Bufalin/Huachansu
3 Brucea javanica
3 Bacopa monnieri
3 Boron
3 Thymol-Thymus vulgaris
3 chaetocin
3 Hydroxycinnamic-acid
3 Cucurbitacin
3 diet FMD Fasting Mimicking Diet
3 Eurycomanone
3 Evodiamine
3 Ginger/6-Shogaol/Gingerol
3 Grapeseed extract
3 isoquercitrin
3 Pterostilbene
3 Sanguinarine
3 Aflavin-3,3′-digallate
2 Auranofin
2 Berbamine
2 Biochanin A
2 Bromelain
2 Sorafenib (brand name Nexavar)
2 Caffeic Acid Phenethyl Ester (CAPE)
2 Centella asiatica / Gotu kola → asiaticoside
2 CUSP9
2 Diclofenac
2 diet Methionine-Restricted Diet
2 D-limonene
2 Geldanamycin
2 Genistein (soy isoflavone)
2 Geraniol
2 Huperzine A/Huperzia serrata
2 Inulin Prebiotic
2 Melatonin
2 Myricetin
2 Oleuropein
2 Plumbagin
2 Parthenolide
2 α-Santalol/Sandalwood oil
1 chemodynamic therapy
1 Camptothecin
1 Acetyl-l-carnitine
1 DTS(dibenzyl trisulphide) from Anamu
1 Andrographis
1 Fennel Oil/Foeniculum vulgare
1 Aspirin
1 Aloe anthraquinones
1 almonertinib
1 borneol
1 Caffeine
1 Trastuzumab
1 hydroxychloroquine
1 Carnosine
1 Chocolate
1 Cichoric acid / Chicoric acid
1 immunotherapy
1 Vitamin E
1 Crocetin
1 gefitinib, erlotinib
1 Photodynamic Therapy
1 Cynaropicrin
1 Dichloroacetophenone(2,2-)
1 Docosahexaenoic Acid
1 Dipyridamole
1 Atorvastatin
1 Disulfiram
1 Copper and Cu NanoParticles
1 Ai-Tong-An-Gao-Ji
1 flavonoids
1 Bortezomib
1 chitosan
1 Ginkgolic acids
1 Ginkgo biloba
1 Gossypol/AT-101
1 Graviola
1 hydrogen sulfide
1 epipolythiodioxopiperazine / epipolythiopiperazine-2,5-dione
1 isoflavones
1 itraconazole
1 Laetrile B17 Amygdalin
1 Licorice
1 Mung Bean Sprouts
1 MCToil
1 Metformin
1 Neem
1 nelfinavir/Viracept
1 Docetaxel
1 Oleocanthal
1 Proanthocyanidins
1 sericin
1 Phenolic Acids
1 Psoralidin
1 Rhein
1 salinomycin
1 Selenate
1 Selenium NanoParticles
1 acetazolamide
1 statins
1 Terminalia bellirica
1 Tomatine
1 Turmerones
1 Vitamin C (Ascorbic Acid)
1 Vitamin D3
1 Wogonin
1 Zinc
1 γ-Tocotrienol

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:4  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

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