| 622- | VitC, | Treatment of Pancreatic Cancer with Pharmacological Ascorbate |
| - | vitro+vivo, | PC, | NA |
| 621- | VitC, | Sixteen-Year History with High Dose Intravenous Vitamin C Treatment for Various Types of Cancer and Other Diseases |
| 620- | VitC, | Case Study: High-Dose Intravenous Vitamin C in the Treatment of a Patient with Adenocarcinoma of the Kidney |
| - | Case Report, | NA, | NA |
| 619- | VitC, | Natural resistance to ascorbic acid induced oxidative stress is mainly mediated by catalase activity in human cancer cells and catalase-silencing sensitizes to oxidative stress |
| 300- | VitC, | ALA, | Combination of High-Dose Parenteral Ascorbate (Vitamin C) and Alpha-Lipoic Acid Failed to Enhance Tumor-Inhibitory Effect But Increased Toxicity in Preclinical Cancer Models |
| - | in-vitro, | BC, | MDA-MB-231 | - | in-vitro, | Colon, | HCT116 | - | in-vitro, | Ovarian, | PANC1 | - | in-vitro, | Pca, | PC3 |
| 114- | VitC, | QC, | Chemoprevention of prostate cancer cells by vitamin C plus quercetin: role of Nrf2 in inducing oxidative stress |
| - | in-vitro, | Pca, | PC3 | - | in-vitro, | Pca, | DU145 |
| 4319- | VitC, | Unraveling the molecular mechanisms of vitamin deficiency in Alzheimer's disease pathophysiology |
| - | Review, | AD, | NA |
| 4468- | VitC, | SSE, | Selenium modulates cancer cell response to pharmacologic ascorbate |
| - | in-vivo, | GBM, | U87MG | - | in-vitro, | CRC, | HCT116 |
| 2485- | VitC, | TACE, | High-Dose Vitamin C Promotes Regression of Multiple Pulmonary Metastases Originating from Hepatocellular Carcinoma |
| - | Case Report, | HCC, | NA |
| 2592- | VitC, | Ascorbic acid restores sensitivity to imatinib via suppression of Nrf2-dependent gene expression in the imatinib-resistant cell line |
| - | in-vitro, | CLL, | NA |
| 3150- | VitC, | Vitamin C: A Review on its Role in the Management of Metabolic Syndrome |
| - | Review, | Obesity, | NA |
| 3140- | VitC, | Vitamin-C-dependent downregulation of the citrate metabolism pathway potentiates pancreatic ductal adenocarcinoma growth arrest |
| - | in-vitro, | PC, | MIA PaCa-2 | - | in-vitro, | Nor, | HEK293 |
| 3141- | VitC, | High-dose Vitamin C inhibits PD-L1 expression by activating AMPK in colorectal cancer |
| - | in-vitro, | CRC, | HCT116 |
| 3142- | VitC, | Vitamin C promotes apoptosis in breast cancer cells by increasing TRAIL expression |
| - | in-vitro, | BC, | MDA-MB-231 | - | in-vitro, | BC, | MCF7 | - | in-vitro, | Nor, | MCF12A |
| 3143- | VitC, | ATO, | Vitamin C enhances the sensitivity of osteosarcoma to arsenic trioxide via inhibiting aerobic glycolysis |
| - | in-vitro, | OS, | NA |
| 3144- | VitC, | Some characteristics of Rabbit muscle phosphofructokinase-1 inhibition by ascorbate |
| - | in-vitro, | Nor, | NA |
| 3145- | VitC, | Vitamin C inhibits the growth of colorectal cancer cell HCT116 and reverses the glucose‐induced oncogenic effect by downregulating the Warburg effect |
| - | in-vitro, | CRC, | HCT116 |
| 3146- | VitC, | Vitamin C protects against hypoxia, inflammation, and ER stress in primary human preadipocytes and adipocytes |
| - | in-vivo, | Nor, | NA |
| 3147- | VitC, | Vitamin C modulates the metabolic and cytokine profiles, alleviates hepatic endoplasmic reticulum stress, and increases the life span of Gulo−/− mice |
| - | in-vivo, | Nor, | NA |
| 3148- | VitC, | Antioxidants in brain tumors: current therapeutic significance and future prospects |
| - | Review, | Var, | NA |
| 3149- | VitC, | Hepatoprotective benefits of vitamin C against perfluorooctane sulfonate-induced liver damage in mice through suppressing inflammatory reaction and ER stress |
| - | in-vivo, | Nor, | NA |
| 3151- | VitC, | Role of Vitamin C in the Function of the Vascular Endothelium |
| - | Review, | Nor, | NA |
| 3139- | VitC, | Vitamin C and sodium bicarbonate enhance the antioxidant ability of H9C2 cells and induce HSPs to relieve heat stress |
| - | in-vitro, | Nor, | H9c2 |
| 3153- | VitC, | Vitamin C Status and Cognitive Function: A Systematic Review |
| - | Review, | AD, | NA |
| - | in-vitro, | Nor, | RAW264.7 | - | in-vitro, | AML, | PLB-985 |
| 3102- | VitC, | Two Faces of Vitamin C—Antioxidative and Pro-Oxidative Agent |
| - | Review, | Var, | NA | - | Review, | Stroke, | NA |
| 3103- | VitC, | Effect of Vitamin C on Reactive Oxygen Species Formation in Erythrocytes of Sickle Cell Anemia Patients |
| - | Human, | Nor, | NA |
| 3104- | VitC, | Pro- and Antioxidant Effects of Vitamin C in Cancer in correspondence to Its Dietary and Pharmacological Concentrations |
| 3105- | VitC, | ROS-lowering doses of vitamins C and A accelerate malignant melanoma metastasis |
| - | Review, | Var, | NA |
| 3106- | VitC, | Protective effect of vitamin C on oxidative stress: a randomized controlled trial |
| - | Trial, | Nor, | NA |
| 3123- | VitC, | Ascorbic Acid Enhances Tet-Mediated 5-Methylcytosine Oxidation and Promotes DNA Demethylation in Mammals |
| - | in-vitro, | Nor, | mESC |
| 3108- | VitC, | QC, | The role of quercetin and vitamin C in Nrf2-dependent oxidative stress production in breast cancer cells |
| - | in-vitro, | BC, | MDA-MB-231 | - | in-vitro, | Lung, | A549 |
| 3109- | VitC, | Vitamin C Inhibited Pulmonary Metastasis through Activating Nrf2/HO-1 Pathway |
| - | in-vitro, | Lung, | H1299 |
| 3110- | VitC, | Vitamin C Attenuates Oxidative Stress, Inflammation, and Apoptosis Induced by Acute Hypoxia through the Nrf2/Keap1 Signaling Pathway in Gibel Carp (Carassius gibelio) |
| - | in-vivo, | Nor, | NA |
| 3111- | VitC, | https://pmc.ncbi.nlm.nih.gov/articles/PMC4492638/ |
| - | Trial, | Nor, | NA |
| 3112- | VitC, | Antioxidative and Anti-Inflammatory Activity of Ascorbic Acid |
| - | Review, | Nor, | NA |
| 3113- | VitC, | Vitamin C enhances NF-κB-driven epigenomic reprogramming and boosts the immunogenic properties of dendritic cells |
| - | in-vitro, | Nor, | NA |
| 3114- | VitC, | Restoration of TET2 Function Blocks Aberrant Self-Renewal and Leukemia Progression |
| - | in-vitro, | AML, | NA |
| 3115- | VitC, | The NF-κB Transcriptional Network Is a High-Dose Vitamin C-Targetable Vulnerability in Breast Cancer |
| - | in-vitro, | BC, | NA |
| 3116- | VitC, | Vitamin C Inhibits NF-kB Activation by TNF Via the Activation of p38 Mitogen-Activated Protein Kinase |
| - | in-vitro, | Nor, | ECV304 | - | in-vitro, | Nor, | HUVECs |
| 3117- | VitC, | Vitamin C induces Tet-dependent DNA demethylation and a blastocyst-like state in ES cells |
| - | in-vitro, | Nor, | mESC |
| 3118- | VitC, | Vitamin C boosts DNA demethylation in TET2 germline mutation carriers |
| - | Trial, | Nor, | NA |
| 3119- | VitC, | Ascorbic acid–induced TET activation mitigates adverse hydroxymethylcytosine loss in renal cell carcinoma |
| - | in-vitro, | RCC, | NA |
| 3120- | VitC, | Upregulation of TET activity with ascorbic acid induces epigenetic modulation of lymphoma cells |
| - | in-vitro, | lymphoma, | NA |
| 3121- | VitC, | immuno, | Ascorbic acid induced TET2 enzyme activation enhances cancer immunotherapy efficacy in renal cell carcinoma |
| - | in-vivo, | RCC, | A498 | - | in-vitro, | RCC, | 786-O |
| 3122- | VitC, | Ascorbic Acid Promotes Plasma Cell Differentiation through Enhancing TET2/3-Mediated DNA Demethylation |
| 3107- | VitC, | Repurposing Vitamin C for Cancer Treatment: Focus on Targeting the Tumor Microenvironment |
| - | Review, | Var, | NA |
| 3124- | VitC, | Ascorbic acid improves parthenogenetic embryo development through TET proteins in mice |
| - | in-vivo, | Nor, | NA |
| 3125- | VitC, | Vitamin C inhibits NLRP3 inflammasome activation and delays the development of age-related hearing loss in male C57BL/6 mice |
| - | in-vivo, | Nor, | NA |
| 3126- | VitC, | Safety of High-Dose Vitamin C in Non-Intensive Care Hospitalized Patients with COVID-19: An Open-Label Clinical Study |
| - | Study, | NA, | NA |
Query results interpretion may depend on "conditions" listed in the research papers. Such Conditions may include : -low or high Dose -format for product, such as nano of lipid formations -different cell line effects -synergies with other products -if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:% IllCat:% CanType:% Cells:% prod#:% Target#:% State#:% Dir#:%
wNotes=0 sortOrder:rid,rpid