TumCCA Cancer Research Results

TumCCA, Tumor cell cycle arrest: Click to Expand ⟱
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Tumor cell cycle arrest refers to the process by which cancer cells stop progressing through the cell cycle, which is the series of phases that a cell goes through to divide and replicate. This arrest can occur at various checkpoints in the cell cycle, including the G1, S, G2, and M phases. S, G1, G2, and M are the four phases of mitosis.
Scientific Papers found: Click to Expand⟱
3323- SIL,    Anticancer therapeutic potential of silibinin: current trends, scope and relevance
- Review, Var, NA
Inflam↓, angioG↓, antiOx↑, TumMeta↓, TumCP↓, TumCCA↑, TumCD↑, α-SMA↓, p‑Akt↓, p‑STAT3↓, COX2/PTGS2↓, IL6↓, MMP2↓, HIF-1↓, Snail↓, Slug↓, Zeb1↓, NF-kB↓, p‑EGFR↓, JAK2↓, PI3K↓, PD-L1↓, VEGF↓, CDK4↓, CDK2↓, cycD1/CCND1↓, E2Fs↓,
1316- SIL,  Chemo,    Silymarin and Cancer: A Dual Strategy in Both in Chemoprevention and Chemosensitivity
- Analysis, Var, NA
TumCCA↑, p42↓, P450↓, OATPs↓, chemoP↑, ChemoSen↑,
978- SIL,    A comprehensive evaluation of the therapeutic potential of silibinin: a ray of hope in cancer treatment
- Review, NA, NA
PI3K↓, Akt↓, NF-kB↓, Wnt/(β-catenin)↓, MAPK↓, TumCP↓, TumCCA↑, Apoptosis↑, p‑EGFR↓, JAK2↓, STAT5↓, cycD1/CCND1↓, hTERT/TERT↓, AP-1↓, MMP9↓, miR-21↓, miR-155↓, Casp9↑, BID↑, ERK↓, Akt2↓, DNMT1↓, P53↑, survivin↓, Casp3↑, ROS↑,
2230- SK,    Shikonin induces ROS-based mitochondria-mediated apoptosis in colon cancer
- in-vitro, CRC, HCT116 - in-vivo, NA, NA
TumCG↓, Bcl-2↓, ROS↑, Bcl-xL↓, MMP↓, Casp↑, selectivity↑, cycD1/CCND1↓, TumCCA↑, eff↓,
2198- SK,    Shikonin suppresses proliferation of osteosarcoma cells by inducing ferroptosis through promoting Nrf2 ubiquitination and inhibiting the xCT/GPX4 regulatory axis
- in-vitro, OS, MG63 - in-vitro, OS, 143B
TumCP↓, TumCCA↑, Ferroptosis↑, Iron↑, ROS↑, lipid-P↑, MDA↑, mtDam↑, NRF2↓, xCT/SLC7A11↓, GPx4↓, GSH/GSSG↓, Keap1↑,
2194- SK,    Efficacy of Shikonin against Esophageal Cancer Cells and its possible mechanisms in vitro and in vivo
- in-vitro, ESCC, Eca109 - in-vitro, ESCC, EC9706 - in-vivo, NA, NA
tumCV↓, TumCCA↑, Apoptosis↑, EGFR↓, PI3K↓, Hif1a↓, PKM2↓, cycD1/CCND1↓, AntiTum↑,
2229- SK,    Shikonin induces apoptosis and prosurvival autophagy in human melanoma A375 cells via ROS-mediated ER stress and p38 pathways
- in-vitro, Melanoma, A375
Apoptosis↑, TumAuto↑, TumCP↓, TumCCA↑, P21↑, cycD1/CCND1↓, ER Stress↑, p‑eIF2α↑, CHOP/DDIT3↑, cl‑Casp3↑, p38↑, LC3B-II↑, Beclin-1↑, ROS↑, eff↓,
2227- SK,    Shikonin induces mitochondria-mediated apoptosis and enhances chemotherapeutic sensitivity of gastric cancer through reactive oxygen species
- in-vitro, GC, BGC-823 - in-vitro, GC, SGC-7901 - in-vitro, Nor, GES-1
selectivity↑, TumCP↓, TumCD↑, ROS↑, MMP↓, Casp↑, Cyt‑c↑, Endon↑, AIF↑, eff↓, ChemoSen↑, TumCCA↑, GSH/GSSG↓, lipid-P↑,
3044- SK,    Shikonin Inhibits Non-Small-Cell Lung Cancer H1299 Cell Growth through Survivin Signaling Pathway
- in-vitro, Lung, H1299 - in-vitro, Lung, H460
TumCP↓, survivin↓, TumCCA↓, CDK2↓, CDK4↓, XIAP↓, Casp3↑, Casp9↑, cycD1/CCND1↓, cycE/CCNE↓,
3043- SK,    Shikonin Induces Apoptosis by Inhibiting Phosphorylation of IGF-1 Receptor in Myeloma Cells.
- in-vitro, Melanoma, RPMI-8226
IGF-1↓, Apoptosis↑, TumCCA↑, MMP↓, Casp3↑, P53↑, BAX↑, Mcl-1↓, EGFR↓, Src↑, VEGFR2/KDR/Flk1↓, p‑IGF-1↓, PI3K↓, Akt↓,
3040- SK,    Pharmacological Properties of Shikonin – A Review of Literature since 2002
- Review, Var, NA - Review, IBD, NA - Review, Stroke, NA
*Half-Life↝, *BioAv↓, *BioAv↑, *BioAv↑, *Inflam↓, *TNF-α↓, *other↑, *MPO↓, *COX2/PTGS2↓, *NF-kB↑, *STAT3↑, *antiOx↑, *ROS↓, *neuroP↑, *SOD↑, *Catalase↑, *GPx↑, *Bcl-2↑, *BAX↓, cardioP↑, AntiCan↑, NF-kB↓, ROS↑, PKM2↓, TumCCA↑, Necroptosis↑, Apoptosis↑, DNAdam↑, MMP↓, Cyt‑c↑, LDH↝,
3047- SK,    Shikonin suppresses colon cancer cell growth and exerts synergistic effects by regulating ADAM17 and the IL-6/STAT3 signaling pathway
- in-vitro, CRC, HCT116 - in-vitro, CRC, SW48
TumCG↓, p‑STAT3↓, ADAM17↓, Apoptosis↑, Casp3↑, cl‑PARP↑, cycD1/CCND1↓, cycE/CCNE↓, TumCCA↑, JAK1?, p‑JAK1↓, p‑JAK2↓, p‑eIF2α↑, eff↓, ROS↑, IL6↓,
5102- SK,  GEM,    Shikonin suppresses tumor growth and synergizes with gemcitabine in a pancreatic cancer xenograft model: Involvement of NF-κB signaling pathway
TumCG↓, ChemoSen↑, NF-kB↓, PCNA↓, Ki-67↓, p‑EGFR↓, ROS↑, TumCCA↑, P53↑, JNK↑, Akt↓,
5104- SK,    Shikonin induces cell cycle arrest in human gastric cancer (AGS) by early growth response 1 (Egr1)-mediated p21 gene expression.
- in-vitro, GC, AGS
TumCP↓, TumCCA↑, P21↑,
2008- SK,  Cisplatin,    Enhancement of cisplatin-induced colon cancer cells apoptosis by shikonin, a natural inducer of ROS in vitro and in vivo
- in-vitro, CRC, HCT116 - in-vivo, NA, NA
ChemoSen↑, selectivity↑, i-ROS↑, DNAdam↑, MMP↓, TumCCA↑, eff↓, *toxicity↓,
1312- SK,    Shikonin induces apoptosis through reactive oxygen species/extracellular signal-regulated kinase pathway in osteosarcoma cells
- in-vitro, OS, 143B
ROS↑, p‑ERK↑, Bcl-2↓, cl‑PARP↑, Apoptosis↑, TumCCA↑, Bcl-2↑, proCasp3↓,
965- SK,    Shikonin suppresses proliferation and induces cell cycle arrest through the inhibition of hypoxia-inducible factor-1α signaling
- in-vitro, CRC, HCT116 - in-vitro, CRC, SW-620
Hif1a↓, ROS↓, mTOR↓, p70S6↓, 4E-BP1↓, eIF2α↓, TumCCA↑, TumCP↓, Half-Life↝,
1291- SM,    Tanshinone IIA inhibits human breast cancer cells through increased Bax to Bcl-xL ratios
- in-vitro, BC, MDA-MB-231
TumCP↓, TumCCA↑, BAX↑, Bcl-2↓,
4891- Sper,    Spermidine as a promising anticancer agent: Recent advances and newer insights on its molecular mechanisms
- Review, Var, NA - Review, AD, NA
TumCCA↑, TumCP↓, TumCG↓, *Inflam↓, *antiOx↑, *neuroP↑, *cognitive↑, *Aβ↓, *mitResp↑, AntiCan↑, TumCD↑, TumAuto↑, *AntiAge↑, LC3B-II↑, ATG5↑, Beclin-1↑, mt-ROS↑, H2O2↑, Apoptosis↑, *ROS↑, ChemoSen↑, MMP↓, Cyt‑c↑,
1062- SSE,    Sodium Selenite Decreased HDAC Activity, Cell Proliferation and Induced Apoptosis in Three Human Glioblastoma Cells
- in-vitro, GBM, LN229 - in-vitro, GBM, T98G - in-vitro, GBM, U87MG
HDAC↓, TumCP↓, TumCCA↑, Apoptosis↑, Casp3↝, MMP2↓, *BioAv↝,
1002- SSE,  Osi,  Adag,    Selenite as a dual apoptotic and ferroptotic agent synergizes with EGFR and KRAS inhibitors with epigenetic interference
- in-vitro, Lung, H1975 - in-vitro, Lung, H385
Apoptosis↑, Ferroptosis↑, DNMT1↓, TET1↑, TumCCA↑, cl‑PARP↑, cl‑Casp3↑, Cyt‑c↑, BIM↑, NOXA↑, Apoptosis↑, ROS↑, ER Stress↑, UPR↑,
4739- SSE,  Chemo,  Rad,    Therapeutic Benefits of Selenium in Hematological Malignancies
- Review, Var, NA
ChemoSen↑, radioP↑, QoL↑, Risk↓, *selenoP↑, TumCP↓, Inflam↓, ChemoSen↑, TumCCA↑, Apoptosis↑, angioG↓, Dose⇅, ROS↑, eff↑, Risk↓, eff∅, CSCs↓, ROS↑,
5081- SSE,    Application Notes and Protocols: Selenite as a Selenium Source in Cell Culture Media Supplementation
- Review, Var, NA
Dose↝, ROS↑, Akt↓, mTOR↓, TumCCA↑, Apoptosis↑,
5109- SSE,    Selenium compounds activate ATM-dependent DNA damage response via the mismatch repair protein hMLH1 in colorectal cancer cells
- in-vitro, CRC, HCT116
ROS↑, DNAdam↓, ATM↑, eff↓, TumCCA↑,
5089- SSE,  Se,    Redox-mediated effects of selenium on apoptosis and cell cycle in the LNCaP human prostate cancer cell line
- in-vitro, Pca, LNCaP
ROS↑, mtDam↑, TumCD↑, Apoptosis↑, TumCCA↑, Trx↓, angioG↓, GSH⇅, NADPH↓, GPx↑,
6431- T4O,    Terpinen-4-ol Induces Apoptosis in Human Nonsmall Cell Lung Cancer In Vitro and In Vivo
- vitro+vivo, NSCLC, A549
TumCCA↑, Casp3↑, Casp9↑, cl‑PARP↑, MMP↓, Bax:Bcl2↑, XIAP↓, survivin↓, Dose↝, Apoptosis↑, tumCV↓, Cyt‑c↑, eff↑, necrosis↑,
6436- T4O,    Terpinen-4-ol suppresses proliferation and motility of cutaneous squamous cell carcinoma cells by enhancing calpain-2 expression
- in-vitro, Melanoma, A431
TumCP↓, TumCMig↓, TumCI↓, Apoptosis↑, EMT↓, AntiTum↑, cal2↑, cl‑β-catenin/ZEB1↑, cl‑Casp12↑, Bcl-2↓, cycD1/CCND1↓, CDK2↓, BAX↑, TumCCA↑, selectivity↑, N-cadherin↓, E-cadherin↑, Ki-67↓, PCNA↑,
5339- TFdiG,    Pre-treated theaflavin-3,3′-digallate has a higher inhibitory effect on the HCT116 cell line
- in-vitro, CRC, HCT116
eff↑, TumCCA↑, Inflam↓, COX2/PTGS2↓, iNOS↓, P53↑, P21↑, cl‑Casp3↑,
5327- TFdiG,    Theaflavin-3, 3'-digallate induces apoptosis and G2 cell cycle arrest through the Akt/MDM2/p53 pathway in cisplatin-resistant ovarian cancer A2780/CP70 cells
- in-vitro, Ovarian, A2780S
TumCG↓, selectivity↑, TumCCA↑, Apoptosis↑, P53↑, BAX↑, BAD↑, cl‑Casp3↑, p‑Akt↓, MDM2↓, MMP↓, Cyt‑c↑,
5331- TFdiG,    Anti-Cancer Properties of Theaflavins
- Review, Var, NA
AntiCan↑, TumCP↓, TumCMig↓, Apoptosis↑, cl‑PARP↑, cl‑Casp3↑, cl‑Casp7↑, cl‑Casp8↑, cl‑Casp9↑, BAX↑, Bcl-2↓, p‑Akt↓, p‑mTOR↓, PI3K↓, cMyc↓, P53↑, ROS↑, NF-kB↓, MMP9↓, MMP2↓, TumVol↓, PSA↓, TumCCA↑, VEGF↓, Hif1a↓, CDK2↓, CDK4↓, GSH↓, Dose↑, BioAv↓, BioAv↓, BioAv↑,
5333- TFdiG,    Theaflavin-3,3′-Digallate Plays a ROS-Mediated Dual Role in Ferroptosis and Apoptosis via the MAPK Pathway in Human Osteosarcoma Cell Lines and Xenografts
- vitro+vivo, OS, MG63
tumCV↓, TumCP↓, TumCCA↑, Iron↑, ROS↑, GSH↓, Fenton↑, Ferroptosis↑, Apoptosis↑, MAPK↑, ERK↑, JNK↑, p38↑, TumCG↓, Dose↝, FTH1↓, GPx4↓,
962- TQ,    Thymoquinone affects hypoxia-inducible factor-1α expression in pancreatic cancer cells via HSP90 and PI3K/AKT/mTOR pathways
- in-vitro, PC, PANC1 - in-vitro, Nor, hTERT-HPNE - in-vitro, PC, AsPC-1 - in-vitro, PC, Bxpc-3
TumCMig↓, TumCI↓, Apoptosis↑, Hif1a↓, PI3k/Akt/mTOR↓, TumCCA↑, *toxicity↓, *TumCI∅, *TumCMig∅,
1930- TQ,    Therapeutic implications and clinical manifestations of thymoquinone
- Review, Var, NA
AntiCan↑, antiOx↑, Inflam↓, TumCP↓, TumCCA↑, Apoptosis↑, ROS↑, TumMeta↓, TumCI↓,
1931- TQ,  doxoR,    Thymoquinone enhances the anticancer activity of doxorubicin against adult T-cell leukemia in vitro and in vivo through ROS-dependent mechanisms
- in-vivo, AML, NA
eff↑, tumCV↓, TumCCA↑, ROS↑, MMP↓, eff↑, TumVol↓, eff↑, Ki-67↓,
1933- TQ,    Thymoquinone: potential cure for inflammatory disorders and cancer
- Review, Var, NA
antiOx↑, Inflam↓, AntiCan↑, TumCCA↑, ROS↑, angioG↓, Apoptosis↑, Casp↑, eff↑, eff↝,
1935- TQ,    Potential anticancer properties and mechanisms of thymoquinone in osteosarcoma and bone metastasis
- Review, OS, NA
Apoptosis↑, TumCCA↑, angioG↓, TumMeta↓, ROS↑, P53↑, Twist↓, E-cadherin↑, N-cadherin↓, NF-kB↓, IL8↓, XIAP↓, Bcl-2↓, STAT3↓, MAPK↓, PI3K↓, Akt↓, ERK↓, MMP2↓, MMP9↓, *ROS↓, HO-1↑, selectivity↑, TumCG↓,
2124- TQ,    Thymoquinone: an emerging natural drug with a wide range of medical applications
- Review, Var, NA
hepatoP↑, Bax:Bcl2↑, cycD1/CCND1↓, P21↑, TRAIL↑, P53↑, TumCCA↑, hepatoP↑, *ALAT↓, *AST↓, *MDA↓, *GSSG↓, *COX2/PTGS2↓, *lipid-P↓, PPARγ↑, p38↑, ROS↑, ChemoSen↑, selectivity↑, selectivity↑, *MDA↓, *SOD↑,
2122- TQ,    Review on Molecular and Therapeutic Potential of Thymoquinone in Cancer
- Review, Var, NA
ChemoSen↓, *ROS↓, *GSH↑, RenoP↑, hepatoP↑, COX2/PTGS2↓, NF-kB↓, chemoPv↑, neuroP↑, TumCCA↑, P21↑, p27/CDKN1B↑, ROS↑, DNAdam↑, MUC4↓,
2127- TQ,    Therapeutic Potential of Thymoquinone in Glioblastoma Treatment: Targeting Major Gliomagenesis Signaling Pathways
- Review, GBM, NA
chemoP↑, ChemoSen↑, BioAv↑, PTEN↑, PI3K↓, Akt↓, TumCCA↓, NF-kB↓, p‑Akt↓, p65↓, XIAP↓, Bcl-2↓, COX2/PTGS2↓, VEGF↓, mTOR↓, RAS↓, Raf↓, MEK↓, ERK↓, MMP2↓, MMP9↓, TumCMig↓, TumCI↓, Casp↑, cl‑PARP↑, ROS⇅, ROS↑, MMP↓, eff↑, Telomerase↓, DNAdam↑, Apoptosis↑, STAT3↓, RadioS↑,
2129- TQ,  doxoR,    Thymoquinone up-regulates PTEN expression and induces apoptosis in doxorubicin-resistant human breast cancer cells
- in-vitro, BC, MCF7
ChemoSen↑, PTEN↑, p‑Akt↓, TumCCA↑, P53↑, P21↑, Apoptosis↑, MMP↓, Casp↑, cl‑PARP↑, Bax:Bcl2↑, eff↓, DNAdam↓, p‑γH2AX↑, ROS↑,
2084- TQ,    Thymoquinone, as an anticancer molecule: from basic research to clinical investigation
- Review, Var, NA
*ROS↓, *chemoPv↑, ROS↑, ROS⇅, MUC4↓, selectivity↑, AR↓, cycD1/CCND1↓, Bcl-2↓, Bcl-xL↓, survivin↓, Mcl-1↓, VEGF↓, cl‑PARP↑, ROS↑, HSP70/HSPA5↑, P53↑, miR-34a↑, Rac1↓, TumCCA↑, NOTCH↓, NF-kB↓, IκB↓, p‑p65↓, IAP1↓, IAP2/BIRC3↑, XIAP↓, TNF-α↓, COX2/PTGS2↓, Inflam↓, α-tubulin↓, Twist↓, EMT↓, mTOR↓, PI3K↓, Akt↓, BioAv↓, ChemoSen↑, BioAv↑, PTEN↑, chemoPv↑, RadioS↑, *Half-Life↝, *BioAv↝,
2095- TQ,    Review on the Potential Therapeutic Roles of Nigella sativa in the Treatment of Patients with Cancer: Involvement of Apoptosis
- Review, Var, NA
TumCCA↑, Apoptosis↑, ROS↑, Cyt‑c↑, Bax:Bcl2↑, Casp3↑, Casp9↑, cl‑PARP↑, P53↑, P21↑, cMyc↓, hTERT/TERT↓, cycD1/CCND1↓, CDK4↓, NF-kB↓, IAP1↓, IAP2/BIRC3↓, XIAP↓, Bcl-xL↓, survivin↓, COX2/PTGS2↓, MMP9↓, VEGF↓, eff↑,
2105- TQ,    Thymoquinone Promotes Pancreatic Cancer Cell Death and Reduction of Tumor Size through Combined Inhibition of Histone Deacetylation and Induction of Histone Acetylation
- in-vitro, PC, AsPC-1 - in-vitro, PC, MIA PaCa-2 - in-vitro, PC, Hs766t - in-vivo, NA, NA
tumCV↓, TumCP↓, TumCCA↑, Apoptosis↑, P53↑, Bcl-2↓, P21↑, ac‑H4↑, HDAC↓, HDAC1↓, HDAC2↓, HDAC3↓, TumVol↓,
2106- TQ,    Cancer: Thymoquinone antioxidant/pro-oxidant effect as potential anticancer remedy
- Review, Var, NA
Apoptosis↑, TumCCA↑, ROS↑, *Catalase↑, *SOD↑, *GR↑, *GSTA1↓, *GPx↑, *H2O2↓, *ROS↓, *lipid-P↓, *HO-1↑, p‑Akt↓, AMPKα↑, NK cell↑, selectivity↑, Dose↝, eff↑, GSH↓, eff↓, P53↑, p‑STAT3↓, PI3K↑, MAPK↑, GSK‐3β↑, ChemoSen↑, RadioS↑, BioAv↓, NRF2↑,
2108- TQ,    Anti-cancer properties and mechanisms of action of thymoquinone, the major active ingredient of Nigella sativa
- Review, Var, NA
HDAC↓, TumCCA↑, cycD1/CCND1↓, p16↑, P53↑, Bax:Bcl2↑, Bcl-xL↓, NF-kB↓, IAP1↓, IAP2/BIRC3↓, XIAP↓, survivin↓, COX2/PTGS2↓, cMyc↓, ROS↑, Casp3↑, cl‑PARP↑, Cyt‑c↑, STAT3↓,
4565- TQ,    Thymoquinone in the clinical treatment of cancer: Fact or fiction?
- Review, BC, NA
Dose↝, TumCCA↑, P21↑, cycD1/CCND1↓, TumCI↑, TumMeta↓, Bcl-2↓, Bcl-xL↓, survivin↓, PTEN↑, Akt↓, P53↑, NF-kB↓, cardioP↑, Dose↝,
3559- TQ,    Molecular signaling pathway targeted therapeutic potential of thymoquinone in Alzheimer’s disease
- Review, AD, NA - Review, Var, NA
*antiOx↑, *Inflam↓, *AChE↓, AntiCan↑, *cardioP↑, *RenoP↑, *neuroP↑, *hepatoP↑, TumCG↓, Apoptosis↑, PI3K↓, Akt↑, TumCCA↑, angioG↓, *NF-kB↓, *TLR2↓, *TLR4↓, *MyD88↓, *TRIF↓, *IRF3↓, *IL1β↓, *IL6↓, *IL12↓, *NRF2↑, *COX2/PTGS2↓, *VEGF↓, *MMP9↓, *cMyc↓, *cycD1/CCND1↓, *TumCP↓, *TumCI↓, *MDA↓, *TGF-β↓, *CRP↓, *Casp3↓, *GSH↑, *IL10↑, *iNOS↑, *lipid-P↓, *SOD↑, *H2O2↓, *ROS↓, *LDH↓, *Catalase↑, *GPx↑, *AChE↓, *cognitive↑, *MAPK↑, *JNK↑, *BAX↓, *memory↑, *Aβ↓, *MMP↑,
3571- TQ,    The Role of Thymoquinone in Inflammatory Response in Chronic Diseases
- Review, Var, NA - Review, Stroke, NA
*BioAv↓, *BioAv↑, *Inflam↓, *antiOx↑, *ROS↓, *GSH↑, *GSTs↑, *MPO↓, *NF-kB↓, *COX2/PTGS2↓, *IL1β↓, *TNF-α↓, *IFN-γ↓, *IL6↓, *cardioP↑, *lipid-P↓, *TAC↑, *RenoP↑, Apoptosis↑, TumCCA↑, TumCP↓, TumCMig↓, angioG↓, TNF-α↓, NF-kB↓, ROS↑, EMT↓, *Aβ↓, *p‑tau↓, *BACE/β-secretase↓, *TLR2↓, *TLR4↓, *MyD88↓, *IRF3↓, *eff↑, eff↑, DNAdam↑, *iNOS↓,
3408- TQ,    Thymoquinone: A small molecule from nature with high therapeutic potential
- Review, AD, NA - Review, Park, NA
*neuroP↑, *hepatoP↑, *cardioP↑, *Inflam↓, *antiOx↑, ChemoSen↑, eff↑, eff↑, TumCP↓, TumCCA↑, angioG↓, cycA1/CCNA1↓, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓,
3403- TQ,    A multiple endpoint approach reveals potential in vitro anticancer properties of thymoquinone in human renal carcinoma cells
- in-vitro, RCC, 786-O
tumCV↓, ROS↑, TumCCA↑, eff↓, TumCI↓,

Showing Research Papers: 901 to 950 of 982
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 982

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 3,   Fenton↑, 1,   Ferroptosis↑, 3,   GPx↑, 1,   GPx4↓, 2,   GSH↓, 3,   GSH⇅, 1,   GSH/GSSG↓, 2,   H2O2↑, 1,   HO-1↑, 1,   Iron↑, 2,   Keap1↑, 1,   lipid-P↑, 2,   MDA↑, 1,   NRF2↓, 1,   NRF2↑, 1,   ROS↓, 1,   ROS↑, 32,   ROS⇅, 2,   i-ROS↑, 1,   mt-ROS↑, 1,   Trx↓, 1,   xCT/SLC7A11↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

FTH1↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

AIF↑, 1,   MEK↓, 1,   MMP↓, 11,   mtDam↑, 2,   p42↓, 1,   Raf↓, 1,   XIAP↓, 7,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

cMyc↓, 3,   LDH↝, 1,   NADPH↓, 1,   PI3k/Akt/mTOR↓, 1,   PKM2↓, 2,   PPARγ↑, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 8,   Akt↑, 1,   p‑Akt↓, 6,   Apoptosis↑, 30,   BAD↑, 1,   BAX↑, 5,   Bax:Bcl2↑, 5,   Bcl-2↓, 10,   Bcl-2↑, 1,   Bcl-xL↓, 5,   BID↑, 1,   BIM↑, 1,   Casp↑, 5,   cl‑Casp12↑, 1,   Casp3↑, 7,   Casp3↝, 1,   cl‑Casp3↑, 5,   proCasp3↓, 1,   cl‑Casp7↑, 1,   cl‑Casp8↑, 1,   Casp9↑, 4,   cl‑Casp9↑, 1,   Cyt‑c↑, 8,   Endon↑, 1,   Ferroptosis↑, 3,   hTERT/TERT↓, 2,   IAP1↓, 3,   IAP2/BIRC3↓, 2,   IAP2/BIRC3↑, 1,   iNOS↓, 1,   JNK↑, 2,   MAPK↓, 2,   MAPK↑, 2,   Mcl-1↓, 2,   MDM2↓, 1,   Necroptosis↑, 1,   necrosis↑, 1,   NOXA↑, 1,   p27/CDKN1B↑, 1,   p38↑, 3,   survivin↓, 7,   Telomerase↓, 1,   TRAIL↑, 1,   TumCD↑, 4,  

Kinase & Signal Transduction(tgid=6) ⓘ

AMPKα↑, 1,   p70S6↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ac‑H4↑, 1,   miR-21↓, 1,   tumCV↓, 6,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 1,   eIF2α↓, 1,   p‑eIF2α↑, 2,   ER Stress↑, 2,   HSP70/HSPA5↑, 1,   UPR↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 1,   Beclin-1↑, 2,   LC3B-II↑, 2,   TumAuto↑, 2,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 1,   DNAdam↓, 2,   DNAdam↑, 5,   DNMT1↓, 2,   p16↑, 1,   P53↑, 15,   cl‑PARP↑, 10,   PCNA↓, 1,   PCNA↑, 1,   p‑γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 5,   CDK4↓, 4,   cycA1/CCNA1↓, 1,   cycD1/CCND1↓, 14,   cycE/CCNE↓, 3,   E2Fs↓, 1,   P21↑, 9,   TumCCA↓, 2,   TumCCA↑, 48,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

4E-BP1↓, 1,   CSCs↓, 1,   EMT↓, 3,   ERK↓, 3,   ERK↑, 1,   p‑ERK↑, 1,   GSK‐3β↑, 1,   HDAC↓, 3,   HDAC1↓, 1,   HDAC2↓, 1,   HDAC3↓, 1,   IGF-1↓, 1,   p‑IGF-1↓, 1,   miR-34a↑, 1,   mTOR↓, 4,   p‑mTOR↓, 1,   NOTCH↓, 1,   PI3K↓, 9,   PI3K↑, 1,   PTEN↑, 4,   RAS↓, 1,   Src↑, 1,   STAT3↓, 3,   p‑STAT3↓, 3,   STAT5↓, 1,   TumCG↓, 8,   Wnt/(β-catenin)↓, 1,  

Migration(tgid=13) ⓘ

Akt2↓, 1,   AP-1↓, 1,   cal2↑, 1,   E-cadherin↑, 2,   Ki-67↓, 3,   miR-155↓, 1,   MMP2↓, 5,   MMP9↓, 5,   MUC4↓, 2,   N-cadherin↓, 2,   Rac1↓, 1,   Slug↓, 1,   Snail↓, 1,   TET1↑, 1,   TumCI↓, 5,   TumCI↑, 1,   TumCMig↓, 5,   TumCP↓, 19,   TumMeta↓, 4,   Twist↓, 2,   Zeb1↓, 1,   α-SMA↓, 1,   α-tubulin↓, 1,   cl‑β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 8,   EGFR↓, 2,   p‑EGFR↓, 3,   HIF-1↓, 1,   Hif1a↓, 4,   VEGF↓, 5,   VEGFR2/KDR/Flk1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

OATPs↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 7,   IL6↓, 2,   IL8↓, 1,   Inflam↓, 6,   IκB↓, 1,   JAK1?, 1,   p‑JAK1↓, 1,   JAK2↓, 2,   p‑JAK2↓, 1,   NF-kB↓, 13,   NK cell↑, 1,   p65↓, 1,   p‑p65↓, 1,   PD-L1↓, 1,   PSA↓, 1,   TNF-α↓, 2,  

Cellular Microenvironment(tgid=17) ⓘ

ADAM17↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 4,   BioAv↑, 3,   ChemoSen↓, 1,   ChemoSen↑, 13,   Dose↑, 1,   Dose⇅, 1,   Dose↝, 6,   eff↓, 9,   eff↑, 13,   eff↝, 1,   eff∅, 1,   Half-Life↝, 1,   P450↓, 1,   RadioS↑, 3,   selectivity↑, 10,  

Clinical Biomarkers(tgid=22) ⓘ

AR↓, 1,   EGFR↓, 2,   p‑EGFR↓, 3,   hTERT/TERT↓, 2,   IL6↓, 2,   Ki-67↓, 3,   LDH↝, 1,   PD-L1↓, 1,   PSA↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 6,   AntiTum↑, 2,   cardioP↑, 2,   chemoP↑, 2,   chemoPv↑, 2,   hepatoP↑, 3,   neuroP↑, 1,   QoL↑, 1,   radioP↑, 1,   RenoP↑, 1,   Risk↓, 2,   TumVol↓, 3,  
Total Targets: 228

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 5,   Catalase↑, 3,   GPx↑, 3,   GSH↑, 3,   GSSG↓, 1,   GSTA1↓, 1,   GSTs↑, 1,   H2O2↓, 2,   HO-1↑, 1,   lipid-P↓, 4,   MDA↓, 3,   MPO↓, 2,   NRF2↑, 1,   ROS↓, 7,   ROS↑, 1,   selenoP↑, 1,   SOD↑, 4,   TAC↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

mitResp↑, 1,   MMP↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 1,   cMyc↓, 1,   LDH↓, 1,  

Cell Death(tgid=5) ⓘ

BAX↓, 2,   Bcl-2↑, 1,   Casp3↓, 1,   iNOS↓, 1,   iNOS↑, 1,   JNK↑, 1,   MAPK↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

cycD1/CCND1↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

STAT3↑, 1,  

Migration(tgid=13) ⓘ

MMP9↓, 1,   TGF-β↓, 1,   TumCI↓, 1,   TumCI∅, 1,   TumCMig∅, 1,   TumCP↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

VEGF↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 4,   CRP↓, 1,   IFN-γ↓, 1,   IL10↑, 1,   IL12↓, 1,   IL1β↓, 2,   IL6↓, 2,   Inflam↓, 5,   MyD88↓, 2,   NF-kB↓, 2,   NF-kB↑, 1,   TLR2↓, 2,   TLR4↓, 2,   TNF-α↓, 2,   TRIF↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 2,   p‑tau↓, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 3,   BACE/β-secretase↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

GR↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 2,   BioAv↑, 3,   BioAv↝, 2,   eff↑, 1,   Half-Life↝, 2,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   AST↓, 1,   CRP↓, 1,   IL6↓, 2,   LDH↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   cardioP↑, 3,   chemoPv↑, 1,   cognitive↑, 2,   hepatoP↑, 2,   memory↑, 1,   neuroP↑, 4,   RenoP↑, 2,   toxicity↓, 2,  

Infection & Microbiome(tgid=24) ⓘ

IRF3↓, 2,  
Total Targets: 80

Scientific Paper Hit Count for: TumCCA, Tumor cell cycle arrest
41 Curcumin
31 Quercetin
29 Silver-NanoParticles
26 Sulforaphane (mainly Broccoli)
25 Thymoquinone
23 Apigenin (mainly Parsley)
22 Berberine
21 Fisetin
17 Phenethyl isothiocyanate
16 Baicalein
16 Emodin
15 Artemisinin
15 Capsaicin
15 Piperlongumine
14 Radiotherapy/Radiation
14 Shikonin
13 Magnetic Fields
13 EGCG (Epigallocatechin Gallate)
13 Chrysin
13 Garcinol
13 Resveratrol
12 Ashwagandha(Withaferin A)
12 Betulinic acid
12 Eugenol
12 Cucurbitacin
12 Honokiol
11 Graviola
11 Magnolol
11 Lycopene
10 Propolis -bee glue
9 Cisplatin
9 Rosmarinic acid
9 Ellagic acid
9 Formononetin
9 IP6 (Inositol 1,2,3,4,5,6-hexakisphosphate)
9 Silymarin (Milk Thistle) silibinin
9 Urolithin
8 5-fluorouracil
8 Allicin (mainly Garlic)
8 Carvacrol
8 Crocetin
8 Ferulic acid
8 Gallic acid
8 Ginkgetin
8 HydroxyTyrosol
8 Luteolin
7 Chemotherapy
7 chitosan
7 Evodiamine
7 Fucoidan
7 Indole-3-carbinol
7 Phenylbutyrate
7 Pterostilbene
6 doxorubicin
6 Astaxanthin
6 Berbamine
6 Boswellia (frankincense)
6 Celastrol
6 chaetocin
6 Paclitaxel/Taxol
6 Gambogic Acid
6 Naringin
6 Selenite (Sodium)
5 Coenzyme Q10
5 Beta-Caryophyllene
5 Bufalin/Huachansu
5 Boron
5 Caffeic Acid Phenethyl Ester (CAPE)
5 Centella asiatica / Gotu kola → asiaticoside
5 Chlorogenic acid
5 Carvone
5 Cynaropicrin
5 Dandelion Root
5 Eurycomanone
5 Fenbendazole
5 Genistein (soy isoflavone)
5 isoorientin
5 Nimbolide
5 Plumbagin
5 salinomycin
5 Ursolic acid
5 Vitamin K2
4 1,8-Cineole
4 Vitamin C (Ascorbic Acid)
4 D-limonene
4 Brucea javanica
4 Caffeic acid
4 Thymol-Thymus vulgaris
4 Selenium
4 Cinnamon
4 Hydroxycinnamic-acid
4 Deguelin
4 Hyperoside
4 Juglone
4 Laetrile B17 Amygdalin
4 Linalool
4 Magnetic Field Rotating
4 VitK3,menadione
4 α-Santalol/Sandalwood oil
4 Selenium NanoParticles
4 Aflavin-3,3′-digallate
3 Astragalus
3 Copper and Cu NanoParticles
3 Alpha-Lipoic-Acid
3 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
3 Andrographis
3 Gemcitabine (Gemzar)
3 Anethole/trans-Anethole
3 Fennel Oil/Foeniculum vulgare
3 Isovitexin
3 Biochanin A
3 borneol
3 Bruteridin(bergamot juice)
3 Carnosic acid
3 Celecoxib
3 Cynara scolymus/Globe Artichoke/Artichoke Extract
3 Date Fruit Extract
3 Piperine
3 Ginger/6-Shogaol/Gingerol
3 Hibiscus sabdariffa
3 Inositol
3 Isoliquiritigenin
3 Metformin
3 Propyl gallate
3 Parthenolide
2 Glucose
2 Gold NanoParticles
2 Photodynamic Therapy
2 tamoxifen
2 DTS(dibenzyl trisulphide) from Anamu
2 Ascorbyl Palmitate
2 Melatonin
2 Atorvastatin
2 beta-glucans
2 Baicalin
2 Bacopa monnieri
2 α-Bisabolol / Chamomile oil
2 Butyrate
2 Zinc
2 Chlorophyllin
2 Docetaxel
2 Dihydrocaffeic Acid
2 Cyclopamine
2 Dichloroacetate
2 Diclofenac
2 diet Methionine-Restricted Diet
2 Echinacea
2 Electrical Pulses
2 carboplatin
2 Geraniol
2 Hyperthermia
2 isoflavones
2 isoquercitrin
2 itraconazole
2 Vitexin
2 Licorice
2 Methylene blue
2 Magnesium
2 Oleuropein
2 Rauwolfia serpentina/Indian Snakeroot
2 Terpinen-4-ol / Tea Tree Oil
1 3-bromopyruvate
1 Ajoene (compound of Garlic)
1 alpha Linolenic acid
1 Arctigenin
1 Aloe anthraquinones
1 immunotherapy
1 epirubicin
1 brusatol
1 Bromelain
1 Carnosine
1 Selenate
1 Chocolate
1 Vitamin E
1 Polyphenols
1 Docosahexaenoic Acid
1 diet FMD Fasting Mimicking Diet
1 Dipyridamole
1 Disulfiram
1 Cannabichromene
1 Citric Acid
1 Sorafenib (brand name Nexavar)
1 flavonoids
1 Arsenic trioxide
1 Vitamin A, Retinoic Acid
1 Shilajit/Fulvic Acid
1 Galloflavin
1 Ginkgolic acids
1 Ginkgo biloba
1 Germanium inorganic
1 Ginkgolide B
1 Ginseng
1 HydroxyCitric Acid
1 Rapamycin
1 High-Ozonide Oil
1 Isobavachalcone
1 iodine
1 Inulin Prebiotic
1 Methylglyoxal
1 Methylsulfonylmethane
1 Mushroom Chaga
1 Myricetin
1 Niclosamide (Niclocide)
1 Proanthocyanidins
1 Sanguinarine
1 Psoralidin
1 Kaempferol
1 Rhein
1 Rutin
1 Oxaliplatin
1 Sulfasalazine
1 Auranofin
1 Salvia miltiorrhiza
1 Spermidine
1 Osimertinib
1 Adagrasib
1 Turmerones
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:322  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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