Cancer Database Query Results

Scientific Papers found: Click to Expand⟱
5263- 3BP,  CET,    3-Bromopyruvate overcomes cetuximab resistance in human colorectal cancer cells by inducing autophagy-dependent ferroptosis
- in-vitro, CRC, DLD1 - NA, NA, HCT116
eff↑, Ferroptosis↓, TumAuto↑, Apoptosis↑, FOXO3↑, AMPKα↑, p‑Beclin-1↑, HK2↓, ATP↓, ROS↑, Dose↝, TumVol↓, TumW↓, xCT↑, GSH↓, eff↓, MDA↑,
5257- 3BP,    Tumor Energy Metabolism and Potential of 3-Bromopyruvate as an Inhibitor of Aerobic Glycolysis: Implications in Tumor Treatment
- Review, Var, NA
Glycolysis↓, mt-OXPHOS↓, HK2↓, Cyt‑c↑, Casp3↓, Bcl-2↓, Mcl-1↓, GAPDH↓, LDH↓, PDH↓, TCA↓, GlutaM↓, GSH↓, ATP↓, mitResp↓, ROS↑, ChemoSen↑, toxicity↝,
5258- 3BP,    3-bromopyruvate: Targets and outcomes
- Review, Var, NA
Glycolysis↓, TumCG↓,
5259- 3BP,    Advanced cancers: eradication in all cases using 3-bromopyruvate therapy to deplete ATP
- in-vivo, HCC, NA
ATP↓, TumCD↑, toxicity↓, eff↑, tumCV↓, Dose↝,
5260- 3BP,    Systemic Delivery of Microencapsulated 3-Bromopyruvate for the Therapy of Pancreatic Cancer
- in-vivo, PC, NA
TumCG↓, toxicity↓, BioAv↝, GAPDH↓, toxicity↑, Dose↝, ATP↓, eff↑, TumCI↓, MMP9↓, toxicity↓,
5261- 3BP,    The cytotoxicity of 3-bromopyruvate in breast cancer cells depends on extracellular pH
- in-vitro, BC, NA
eff↑, eff↓,
5269- 3BP,    The anti-metabolite KAT/3BP has in vitro and in vivo anti-tumor activity in lymphoma models.
- in-vitro, HCC, NA
toxicity↑, eff↝, eff↑, Glycolysis↓, HK2↓, AIF↑, Apoptosis↑, NK cell↑, toxicity↑, toxicity↓, Dose↝, AntiTum↑,
5264- 3BP,    Candidate cancer drug suspected after death of three patients at an alternative medicine clinic
- Review, Var, NA
toxicity↑, Glycolysis↓, eff↑, OS↑, QoL↑, toxicity↝,
5265- 3BP,    KAT/3BP: A Metabolism-Targeting Agent with Single and Combination Activity in Aggressive B-Cell Lymphomas
- Review, lymphoma, NA
Glycolysis↓, HK2↓, AIF↓, Apoptosis↑, NK cell↑,
5266- 3BP,    3-bromopyruvate-based agent KAT-101
- Review, Var, NA
eff↑, Glycolysis↓, OXPHOS↓, ATP↓, TumCP↓, Apoptosis↑, HK2↓, MPT↑, LDH↓, PDH↓,
5267- 3BP,    Targeting Energy Metabolism in Cancer Treatment
- Review, Var, NA
HK2↓,
5270- 5-ALA,  PDT,    5-Aminolevulinic Acid as a Theranostic Agent for Tumor Fluorescence Imaging and Photodynamic Therapy
- Review, Var, NA
other↝, ROS↑, other↝, mtDam↑, Ca+2↑, ER Stress↑, Apoptosis↑, TumAuto↑, other↝, Dose↝, Imm↑,
3453- 5-ALA,    The heme precursor 5-aminolevulinic acid disrupts the Warburg effect in tumor cells and induces caspase-dependent apoptosis
- in-vitro, Lung, A549
OXPHOS↑, OCR↑, Warburg↓, ROS↑, SOD2↑, Catalase↑, HO-1↑, Casp3↑, Apoptosis↑,
3452- 5-ALA,    5-ALA Is a Potent Lactate Dehydrogenase Inhibitor but Not a Substrate: Implications for Cell Glycolysis and New Avenues in 5-ALA-Mediated Anticancer Action
- in-vitro, GBM, T98G - in-vitro, GBM, LN-18 - in-vitro, GBM, U87MG
Glycolysis↓, LDH↓, eff↝, ECAR↓,
4774- 5-FU,  TQ,  CoQ10,    Exploring potential additive effects of 5-fluorouracil, thymoquinone, and coenzyme Q10 triple therapy on colon cancer cells in relation to glycolysis and redox status modulation
- in-vitro, CRC, NA
AntiCan↑, TumCCA↑, Apoptosis↑, eff↑, Bcl-2↓, survivin↓, P21↑, p27↑, BAX↑, Cyt‑c↑, Casp3↑, PI3K↓, Akt↓, mTOR↓, Hif1a↓, PTEN↑, AMPKα↑, PDH↑, LDHA↓, antiOx↓, ROS↑, AntiCan↑,
3537- 5-HTP,    5-Hydroxytryptophan: a clinically-effective serotonin precursor
- Review, NA, NA
*5HT↑, *BioAv↑, *BBB↑,
3538- 5-HTP,    Oral Administration of 5-Hydroxytryptophan Restores Gut Microbiota Dysbiosis in a Mouse Model of Depression
- in-vivo, Nor, NA
*GutMicro↑, *BBB↑, *5HT↑, *Weight↓,
5308- 5-HTP,    The Relationship Between Serotonin and 5-HTP
- Review, Nor, NA
*5HT↑,
5309- 5-HTP,    Effects of Carbidopa on the Cerebral Accumulation of Exogenous L-5-Hydroxytryptophan in Mice
*BioAv↑,
5302- 5-HTP,    Hippocampal ischaemia from accidental 5-Hydroxytryptophan (5-HTP) overdose case report
- Case Report, Nor, NA
*toxicity↑, *Dose↑,
5310- 5-HTP,    5-Hydroxytryptophan toxicity successfully treated by haemodialysis in a dog
- Case Report, Nor, NA
*Dose↑, *toxicity↝,
5311- 5-HTP,    A case report of suspected serotonin syndrome following administration of fentanyl

5303- 5-HTP,    5-HTP shows early promise for cognitive support and in seniors: Singapore study
- Trial, AD, NA
*cognitive↑, *Dose↝, *5HT↑,
5298- 5-HTP,    Pharmacology of rising oral doses of 5-hydroxytryptophan with carbidopa
- Human, AD, NA
*BioAv↑, *Dose↝, *toxicity↝,
5297- 5-HTP,    Targeting 5-HT Is a Potential Therapeutic Strategy for Neurodegenerative Diseases
- in-vivo, AD, NA - in-vivo, Park, NA
*other↝, *cognitive↑, *memory↑, *Ach↑,
5296- 5-HTP,    Serotonergic Regulation in Alzheimer’s Disease
- Review, AD, NA
*Risk↓, *5HT↓, *ROS↓, *MDA↓, *Apoptosis↓, *Mood↑, *other↑, *other↑,
5295- 5-HTP,    Safety of 5-hydroxy-L-tryptophan
- in-vivo, Nor, NA
*5HT↑, *toxicity↝, *toxicity↓,
5294- 5-HTP,    Eosinophilia-myalgia syndrome case-associated contaminants in commercially available 5-hydroxytryptophan
- in-vivo, Nor, NA
*toxicity↑,
5293- 5-HTP,    The Role of Tryptophan Metabolism in Alzheimer’s Disease
- in-vivo, AD, NA
*Sleep↑, *5HT↑, *memory↑, *other↝,
5292- 5-HTP,    Past, present, and future of serotonin-targeting therapeutics for Alzheimer’s disease: Perspectives from DNA methylation
- Review, AD, NA
*other↝, *cognitive↝,
5291- 5-HTP,    Kinetics of l-5-hydroxytryptophan in healthy subjects
- in-vivo, Nor, NA
*Half-Life↝, *BioAv↑,
5290- 5-HTP,    Placebo-controlled comparison of three dose-regimens of 5-hydroxytryptophan challenge test in healthy volunteers
- in-vivo, Nor, NA
*5HT↑,
5289- 5-HTP,    5-Hydroxytryptophan (5-HTP): Natural Occurrence, Analysis, Biosynthesis, Biotechnology, Physiology and Toxicology
- Review, AD, NA - Review, Arthritis, NA
*5HT↑, *Inflam↓, *memory↑, *Sleep↑, *Weight↓, *DNAdam↓, *ROS↓, *toxicity↝,
5288- 5-HTP,    The Impact of 5-Hydroxytryptophan Supplementation on Cognitive Function and Mood in Singapore Older Adults: A Randomized Controlled Trial
- Trial, AD, NA
*5HT↑, *cognitive↑, *BBB↑, *Mood↑,
5304- 5-HTP,    Serotoninergic System in Dementia of the Alzheimer Type
- Human, AD, NA
*Risk↓,
5306- 5-HTP,    Tryptophan-enriched diet or 5-hydroxytryptophan supplementation given in a randomized controlled trial impacts social cognition on a neural and behavioral level
- Trial, AD, NA
*cognitive↑, *Dose↝,
5301- 5-HTP,    Eosinophilia-myalgia syndrome presenting with overlapping features of eosinophilic fasciitis and sarcoidal granulomas
- Case Report, NA, NA
*toxicity↝, *toxicity↝,
5300- 5-HTP,    The Serotonin Syndrome: From Molecular Mechanisms to Clinical Practice
- Review, Nor, NA
*toxicity↝,
5299- 5-HTP,    Serotonin Syndrome from 5-Hydroxytryptophan Supplement Ingestion in a 9-Month-Old Labrador Retriever
- Case Report, AD, NA
*toxicity↝, *toxicity↝,
5307- 5-HTP,    5-Hydroxytryptophan toxicosis in dogs: 1989-1999
- Case Report, Nor, NA
*toxicity↝, *5HT↑, *Dose↝,
5305- 5-HTP,    An Investigation of the Cause of the Eosinophilia–Myalgia Syndrome Associated with Tryptophan Use
- Review, Nor, NA
*toxicity↝, *toxicity↝,
3940- 5HT,    Role of serotonin in Alzheimer's disease: a new therapeutic target?
- Review, AD, NA
*cognitive↑,
3941- 5HT,  dietMed,  VitB12,  FA,  VitC  Nutrition strategies that improve cognitive function
- Review, AD, NA
*other↑, *other↓, *cognitive↑, *eff↑, *eff↑,
5312- acet,    Analgesic Effect of Acetaminophen: A Review of Known and Novel Mechanisms of Action
*COX1↓, *other?, *BBB↑, TRPV1↑,
5313- acet,    Pharmacological hypotheses: Is acetaminophen selective in its cyclooxygenase inhibition?
- Review, Nor, NA
*COX2↓,
5314- acetaz,    Carbonic Anhydrase Inhibitors Targeting Metabolism and Tumor Microenvironment
- Review, Var, NA
AntiTum↑, CA↓,
1094- ACNs,    Anthocyanidins inhibit epithelial-mesenchymal transition through a TGF-β/Smad2 signaling pathway in glioblastoma cells: Anthocyanidins inhibit TGF-β-mediated EMT.
- in-vitro, GBM, U87MG
EMT↓,
1161- ACNs,  immuno,    Bilberry anthocyanin extracts enhance anti-PD-L1 efficiency by modulating gut microbiota
- in-vivo, Colon, MC38
GutMicro↑,
3970- ACNs,    Anthocyanin-rich blueberry extracts and anthocyanin metabolite protocatechuic acid promote autophagy-lysosomal pathway and alleviate neurons damage in in vivo and in vitro models of Alzheimer's disease
- in-vivo, AD, NA
*cognitive↑, *LDH↓, *ROS↓, *neuroP↑,
3968- ACNs,    Enhanced Neuronal Activation with Blueberry Supplementation in Mild Cognitive Impairment
- Human, AD, NA
*BOLD↑, *cognitive?, *eff↑,

Showing Research Papers: 51 to 100 of 6585
Prev Page 2 of 132 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 6585

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress

antiOx↓, 1,   Catalase↑, 1,   Ferroptosis↓, 1,   GSH↓, 2,   HO-1↑, 1,   MDA↑, 1,   OXPHOS↓, 1,   OXPHOS↑, 1,   mt-OXPHOS↓, 1,   ROS↑, 5,   SOD2↑, 1,   xCT↑, 1,  

Mitochondria & Bioenergetics

AIF↓, 1,   AIF↑, 1,   ATP↓, 5,   mitResp↓, 1,   MPT↑, 1,   mtDam↑, 1,   OCR↑, 1,  

Core Metabolism/Glycolysis

ECAR↓, 1,   GAPDH↓, 2,   GlutaM↓, 1,   Glycolysis↓, 7,   HK2↓, 6,   LDH↓, 3,   LDHA↓, 1,   PDH↓, 2,   PDH↑, 1,   TCA↓, 1,   Warburg↓, 1,  

Cell Death

Akt↓, 1,   Apoptosis↑, 7,   BAX↑, 1,   Bcl-2↓, 2,   Casp3↓, 1,   Casp3↑, 2,   Cyt‑c↑, 2,   Ferroptosis↓, 1,   Mcl-1↓, 1,   p27↑, 1,   survivin↓, 1,   TRPV1↑, 1,   TumCD↑, 1,  

Kinase & Signal Transduction

AMPKα↑, 2,  

Transcription & Epigenetics

other↝, 3,   tumCV↓, 1,  

Protein Folding & ER Stress

ER Stress↑, 1,  

Autophagy & Lysosomes

p‑Beclin-1↑, 1,   TumAuto↑, 2,  

Cell Cycle & Senescence

P21↑, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State

EMT↓, 1,   FOXO3↑, 1,   mTOR↓, 1,   PI3K↓, 1,   PTEN↑, 1,   TumCG↓, 2,  

Migration

CA↓, 1,   Ca+2↑, 1,   MMP9↓, 1,   TumCI↓, 1,   TumCP↓, 1,  

Angiogenesis & Vasculature

Hif1a↓, 1,  

Immune & Inflammatory Signaling

Imm↑, 1,   NK cell↑, 2,  

Drug Metabolism & Resistance

BioAv↝, 1,   ChemoSen↑, 1,   Dose↝, 5,   eff↓, 2,   eff↑, 8,   eff↝, 2,  

Clinical Biomarkers

GutMicro↑, 1,   LDH↓, 3,  

Functional Outcomes

AntiCan↑, 2,   AntiTum↑, 2,   OS↑, 1,   QoL↑, 1,   toxicity↓, 4,   toxicity↑, 4,   toxicity↝, 2,   TumVol↓, 1,   TumW↓, 1,  
Total Targets: 82

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress

MDA↓, 1,   ROS↓, 3,  

Core Metabolism/Glycolysis

LDH↓, 1,  

Cell Death

Apoptosis↓, 1,  

Transcription & Epigenetics

Ach↑, 1,   other?, 1,   other↓, 1,   other↑, 3,   other↝, 3,  

DNA Damage & Repair

DNAdam↓, 1,  

Barriers & Transport

BBB↑, 4,  

Immune & Inflammatory Signaling

COX1↓, 1,   COX2↓, 1,   Inflam↓, 1,  

Synaptic & Neurotransmission

5HT↓, 1,   5HT↑, 10,  

Drug Metabolism & Resistance

BioAv↑, 4,   Dose↑, 2,   Dose↝, 4,   eff↑, 3,   Half-Life↝, 1,  

Clinical Biomarkers

GutMicro↑, 1,   LDH↓, 1,  

Functional Outcomes

BOLD↑, 1,   cognitive?, 1,   cognitive↑, 7,   cognitive↝, 1,   memory↑, 3,   Mood↑, 2,   neuroP↑, 1,   Risk↓, 2,   Sleep↑, 2,   toxicity↓, 1,   toxicity↑, 2,   toxicity↝, 12,   Weight↓, 2,  
Total Targets: 36

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:%  State#:%  Dir#:%
wNotes=0 sortOrder:rid,rpid

 

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