Cancer Database Query Results

Scientific Papers found: Click to Expand⟱
5308- 5-HTP,    The Relationship Between Serotonin and 5-HTP
- Review, Nor, NA
*5HT↑,
5309- 5-HTP,    Effects of Carbidopa on the Cerebral Accumulation of Exogenous L-5-Hydroxytryptophan in Mice
*BioAv↑,
5302- 5-HTP,    Hippocampal ischaemia from accidental 5-Hydroxytryptophan (5-HTP) overdose case report
- Case Report, Nor, NA
*toxicity↑, *Dose↑,
5310- 5-HTP,    5-Hydroxytryptophan toxicity successfully treated by haemodialysis in a dog
- Case Report, Nor, NA
*Dose↑, *toxicity↝,
5311- 5-HTP,    A case report of suspected serotonin syndrome following administration of fentanyl

5303- 5-HTP,    5-HTP shows early promise for cognitive support and in seniors: Singapore study
- Trial, AD, NA
*cognitive↑, *Dose↝, *5HT↑,
5298- 5-HTP,    Pharmacology of rising oral doses of 5-hydroxytryptophan with carbidopa
- Human, AD, NA
*BioAv↑, *Dose↝, *toxicity↝,
5297- 5-HTP,    Targeting 5-HT Is a Potential Therapeutic Strategy for Neurodegenerative Diseases
- in-vivo, AD, NA - in-vivo, Park, NA
*other↝, *cognitive↑, *memory↑, *Ach↑,
5296- 5-HTP,    Serotonergic Regulation in Alzheimer’s Disease
- Review, AD, NA
*Risk↓, *5HT↓, *ROS↓, *MDA↓, *Apoptosis↓, *Mood↑, *other↑, *other↑,
5295- 5-HTP,    Safety of 5-hydroxy-L-tryptophan
- in-vivo, Nor, NA
*5HT↑, *toxicity↝, *toxicity↓,
5294- 5-HTP,    Eosinophilia-myalgia syndrome case-associated contaminants in commercially available 5-hydroxytryptophan
- in-vivo, Nor, NA
*toxicity↑,
5293- 5-HTP,    The Role of Tryptophan Metabolism in Alzheimer’s Disease
- in-vivo, AD, NA
*Sleep↑, *5HT↑, *memory↑, *other↝,
5292- 5-HTP,    Past, present, and future of serotonin-targeting therapeutics for Alzheimer’s disease: Perspectives from DNA methylation
- Review, AD, NA
*other↝, *cognitive↝,
5291- 5-HTP,    Kinetics of l-5-hydroxytryptophan in healthy subjects
- in-vivo, Nor, NA
*Half-Life↝, *BioAv↑,
5290- 5-HTP,    Placebo-controlled comparison of three dose-regimens of 5-hydroxytryptophan challenge test in healthy volunteers
- in-vivo, Nor, NA
*5HT↑,
5289- 5-HTP,    5-Hydroxytryptophan (5-HTP): Natural Occurrence, Analysis, Biosynthesis, Biotechnology, Physiology and Toxicology
- Review, AD, NA - Review, Arthritis, NA
*5HT↑, *Inflam↓, *memory↑, *Sleep↑, *Weight↓, *DNAdam↓, *ROS↓, *toxicity↝,
5288- 5-HTP,    The Impact of 5-Hydroxytryptophan Supplementation on Cognitive Function and Mood in Singapore Older Adults: A Randomized Controlled Trial
- Trial, AD, NA
*5HT↑, *cognitive↑, *BBB↑, *Mood↑,
5304- 5-HTP,    Serotoninergic System in Dementia of the Alzheimer Type
- Human, AD, NA
*Risk↓,
5306- 5-HTP,    Tryptophan-enriched diet or 5-hydroxytryptophan supplementation given in a randomized controlled trial impacts social cognition on a neural and behavioral level
- Trial, AD, NA
*cognitive↑, *Dose↝,
5301- 5-HTP,    Eosinophilia-myalgia syndrome presenting with overlapping features of eosinophilic fasciitis and sarcoidal granulomas
- Case Report, NA, NA
*toxicity↝, *toxicity↝,
5300- 5-HTP,    The Serotonin Syndrome: From Molecular Mechanisms to Clinical Practice
- Review, Nor, NA
*toxicity↝,
5299- 5-HTP,    Serotonin Syndrome from 5-Hydroxytryptophan Supplement Ingestion in a 9-Month-Old Labrador Retriever
- Case Report, AD, NA
*toxicity↝, *toxicity↝,
5307- 5-HTP,    5-Hydroxytryptophan toxicosis in dogs: 1989-1999
- Case Report, Nor, NA
*toxicity↝, *5HT↑, *Dose↝,
5305- 5-HTP,    An Investigation of the Cause of the Eosinophilia–Myalgia Syndrome Associated with Tryptophan Use
- Review, Nor, NA
*toxicity↝, *toxicity↝,
3940- 5HT,    Role of serotonin in Alzheimer's disease: a new therapeutic target?
- Review, AD, NA
*cognitive↑,
3941- 5HT,  dietMed,  VitB12,  FA,  VitC  Nutrition strategies that improve cognitive function
- Review, AD, NA
*other↑, *other↓, *cognitive↑, *eff↑, *eff↑,
5312- acet,    Analgesic Effect of Acetaminophen: A Review of Known and Novel Mechanisms of Action
*COX1↓, *other?, *BBB↑, TRPV1↑,
5313- acet,    Pharmacological hypotheses: Is acetaminophen selective in its cyclooxygenase inhibition?
- Review, Nor, NA
*COX2↓,
5314- acetaz,    Carbonic Anhydrase Inhibitors Targeting Metabolism and Tumor Microenvironment
- Review, Var, NA
AntiTum↑, CA↓,
1094- ACNs,    Anthocyanidins inhibit epithelial-mesenchymal transition through a TGF-β/Smad2 signaling pathway in glioblastoma cells: Anthocyanidins inhibit TGF-β-mediated EMT.
- in-vitro, GBM, U87MG
EMT↓,
1161- ACNs,  immuno,    Bilberry anthocyanin extracts enhance anti-PD-L1 efficiency by modulating gut microbiota
- in-vivo, Colon, MC38
GutMicro↑,
3970- ACNs,    Anthocyanin-rich blueberry extracts and anthocyanin metabolite protocatechuic acid promote autophagy-lysosomal pathway and alleviate neurons damage in in vivo and in vitro models of Alzheimer's disease
- in-vivo, AD, NA
*cognitive↑, *LDH↓, *ROS↓, *neuroP↑,
3968- ACNs,    Enhanced Neuronal Activation with Blueberry Supplementation in Mild Cognitive Impairment
- Human, AD, NA
*BOLD↑, *cognitive?, *eff↑,
3969- ACNs,    Blueberry Supplementation in Midlife for Dementia Risk Reduction
- Human, AD, NA
*memory↑, *cognitive↑, *ROS↓,
3971- ACNs,    Blueberry Supplementation Improves Memory in Older Adults
- Human, AD, NA
*antiOx↑, *Inflam↓, *memory↑, *neuroP↑, *cognitive↑, *Mood↑, *glucose↓,
3972- ACNs,    Recent Research on the Health Benefits of Blueberries and Their Anthocyanins
- Review, AD, NA - Review, Park, NA
*cardioP↑, *neuroP↑, *Inflam↓, *antiOx↓, *GutMicro↑, *Half-Life↑, *LDL↓, *adiP↓, *HDL↑, *CRP↓, *IL1β↓, *Risk↓, *Risk↓, *cognitive↑, *memory↑, *other↑, *BOLD↑, *NO↓, *MDA↓, *GSH↑, *VitC↑, *SOD↑, *GPx↑, *eff↓, *eff↓, *eff↓, *eff↝, *Risk↓,
3973- ACNs,    Saskatoon and wild blueberries have higher anthocyanin contents than other Manitoba berries
- Analysis, AD, NA
eff↑,
3865- ACNs,    Consumption of anthocyanin-rich cherry juice for 12 weeks improves memory and cognition in older adults with mild-to-moderate dementia
- Human, AD, NA
*memory↑, *BP↓, *cognitive↑,
3864- ACNs,    Anthocyanins Potentially Contribute to Defense against Alzheimer’s Disease
- Review, AD, NA
*antiOx↑, *Aβ↓, *ROS↓, *cognitive↑, *APP↓, *BBB↑, *Ca+2↓, *ATP↑, *BACE↓, *p‑NF-kB↓, *TNF-α↓, *iNOS↓,
4163- ACNs,  Flav,    Dietary levels of pure flavonoids improve spatial memory performance and increase hippocampal brain-derived neurotrophic factor
- in-vivo, AD, NA
memory↑, *BDNF↑, *cognitive↑,
1- Aco,    Acoschimperoside P, 2'-acetate: a Hedgehog signaling inhibitory constituent from Vallaris glabra
- in-vitro, PC, PANC1 - in-vitro, Pca, DU145
HH↓, PTCH1↓, Bcl-2↓, Gli1↓,
5459- AF,    Auranofin Induces Lethality Driven by Reactive Oxygen Species in High-Grade Serous Ovarian Cancer Cells
- in-vitro, Ovarian, NA
ROS↑, TrxR↓, MMP↓, Apoptosis↑, eff↓, Casp3↑, Casp7↑, DNAdam↑, eff↑, GSH↓, angioG↓, ChemoSen↑, cl‑PARP↑, eff↑,
5466- AF,    Auranofin Inhibition of Thioredoxin Reductase in a Preclinical Model of Small Cell Lung Cancer
- in-vivo, Lung, NA
TrxR↓, Dose↝, RadioS↑, ChemoSen↑, ROS↑, Diff↑, toxicity↓,
5465- AF,    The Thioredoxin Reductase Inhibitor Auranofin Suppresses Pulmonary Metastasis of Osteosarcoma, But Not Local Progression
- in-vitro, OS, NA
TrxR↓, ROS↑, TumCMig↓,
5464- AF,    Inhibition of Thioredoxin-Reductase by Auranofin as a Pro-Oxidant Anticancer Strategy for Glioblastoma: In Vitro and In Vivo Studies
- vitro+vivo, GBM, NA
TrxR↓, BioAv↓, ROS↑, eff↝, TET1?, BioAv↑,
5463- AF,    Will Auranofin Become a Golden New Treatment Against COVID-19?
- Review, Covid, NA
IL6↓, NF-kB↓, ATF2↓, TrxR↓, ROS↑, Apoptosis↑, IL6↓, Dose↑,
5462- AF,    Repurposing Auranofin for Oncology and Beyond: A Brief Overview of Clinical Trials as Mono- and Combination Therapy
- Review, Var, NA
AntiTum↑, Bacteria↓, TrxR↓, ChemoSen↑, Dose↝, ROS↑, Apoptosis↑, mTOR↓,
5461- AF,    Dual inhibition of thioredoxin reductase and proteasome is required for auranofin-induced paraptosis in breast cancer cells
- in-vitro, BC, MDA-MB-231 - in-vitro, Nor, MCF10
Paraptosis↑, ER Stress↑, TrxR↓, selectivity↑, toxicity↝, ROS↑, mt-TrxR1↓, mt-TrxR2↓,
5460- AF,    Auranofin radiosensitizes tumor cells through targeting thioredoxin reductase and resulting overproduction of reactive oxygen species
- vitro+vivo, Var, 4T1
RadioS↑, ROS↑, eff↓, mt-OCR↓, DNAdam↑, Apoptosis↑, TrxR↓, eff↑,
5469- AF,    Ligand supplementation restores the cancer therapy efficacy of the antirheumatic drug auranofin from serum inactivation
- in-vitro, CRC, HCT116
eff↑, Half-Life↑,

Showing Research Papers: 51 to 100 of 5729
Prev Page 2 of 115 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 5729

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress

GSH↓, 1,   ROS↑, 8,   TrxR↓, 8,   mt-TrxR1↓, 1,   mt-TrxR2↓, 1,  

Mitochondria & Bioenergetics

MMP↓, 1,   mt-OCR↓, 1,  

Cell Death

Apoptosis↑, 4,   ATF2↓, 1,   Bcl-2↓, 1,   Casp3↑, 1,   Casp7↑, 1,   Paraptosis↑, 1,   TRPV1↑, 1,  

Protein Folding & ER Stress

ER Stress↑, 1,  

DNA Damage & Repair

DNAdam↑, 2,   cl‑PARP↑, 1,  

Proliferation, Differentiation & Cell State

Diff↑, 1,   EMT↓, 1,   Gli1↓, 1,   HH↓, 1,   mTOR↓, 1,   PTCH1↓, 1,  

Migration

CA↓, 1,   TET1?, 1,   TumCMig↓, 1,  

Angiogenesis & Vasculature

angioG↓, 1,  

Immune & Inflammatory Signaling

IL6↓, 2,   NF-kB↓, 1,  

Drug Metabolism & Resistance

BioAv↓, 1,   BioAv↑, 1,   ChemoSen↑, 3,   Dose↑, 1,   Dose↝, 2,   eff↓, 2,   eff↑, 5,   eff↝, 1,   Half-Life↑, 1,   RadioS↑, 2,   selectivity↑, 1,  

Clinical Biomarkers

GutMicro↑, 1,   IL6↓, 2,  

Functional Outcomes

AntiTum↑, 2,   memory↑, 1,   toxicity↓, 1,   toxicity↝, 1,  

Infection & Microbiome

Bacteria↓, 1,  
Total Targets: 47

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress

antiOx↓, 1,   antiOx↑, 2,   GPx↑, 1,   GSH↑, 1,   HDL↑, 1,   MDA↓, 2,   ROS↓, 5,   SOD↑, 1,   VitC↑, 1,  

Mitochondria & Bioenergetics

ATP↑, 1,  

Core Metabolism/Glycolysis

adiP↓, 1,   glucose↓, 1,   LDH↓, 1,   LDL↓, 1,  

Cell Death

Apoptosis↓, 1,   iNOS↓, 1,  

Transcription & Epigenetics

Ach↑, 1,   other?, 1,   other↓, 1,   other↑, 4,   other↝, 3,  

DNA Damage & Repair

DNAdam↓, 1,  

Migration

APP↓, 1,   Ca+2↓, 1,  

Angiogenesis & Vasculature

NO↓, 1,  

Barriers & Transport

BBB↑, 3,  

Immune & Inflammatory Signaling

COX1↓, 1,   COX2↓, 1,   CRP↓, 1,   IL1β↓, 1,   Inflam↓, 3,   p‑NF-kB↓, 1,   TNF-α↓, 1,  

Synaptic & Neurotransmission

5HT↓, 1,   5HT↑, 8,   BDNF↑, 1,  

Protein Aggregation

Aβ↓, 1,   BACE↓, 1,  

Drug Metabolism & Resistance

BioAv↑, 3,   Dose↑, 2,   Dose↝, 4,   eff↓, 3,   eff↑, 3,   eff↝, 1,   Half-Life↑, 1,   Half-Life↝, 1,  

Clinical Biomarkers

BP↓, 1,   CRP↓, 1,   GutMicro↑, 1,   LDH↓, 1,  

Functional Outcomes

BOLD↑, 2,   cardioP↑, 1,   cognitive?, 1,   cognitive↑, 13,   cognitive↝, 1,   memory↑, 7,   Mood↑, 3,   neuroP↑, 3,   Risk↓, 5,   Sleep↑, 2,   toxicity↓, 1,   toxicity↑, 2,   toxicity↝, 12,   Weight↓, 1,  
Total Targets: 64

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:%  State#:%  Dir#:%
wNotes=0 sortOrder:rid,rpid

 

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