| Features: treatment category |
| Chemotherapy is a treatment approach that uses drugs to target and kill rapidly dividing cells, primarily cancer cells. However, because many normal cells also divide quickly (such as those in the bone marrow, digestive tract, and hair follicles), chemotherapy can also affect these cells, leading to a range of side effects. Main Classes of Chemotherapy Agents and Examples Alkylating Agents: -work by adding alkyl groups to DNA, which interferes with the DNA’s structure and prevents replication. Examples: Cyclophosphamide, Ifosfamide, Melphalan, Chlorambucil, Busulfan. Anti-metabolites: -interfere with DNA and RNA synthesis by substituting for the normal building blocks of nucleic acids. Examples: Methotrexate, 5-Fluorouracil (5-FU), Cytarabine, Gemcitabine, 6-Mercaptopurine. Anti-microtubule Agents: -interfere with the structures that separate chromosomes during cell division (mitosis). Examples: Paclitaxel, Docetaxel, Vincristine, Vinblastine. Topoisomerase Inhibitors: -target the enzymes topoisomerase I and II, which control the changes in DNA structure required for replication. Examples: Etoposide (topoisomerase II inhibitor), Irinotecan (topoisomerase I inhibitor), Topotecan. Cytotoxic Antibiotics: -intercalate into DNA, inhibiting the replication of cancer cells. Examples: Doxorubicin, Daunorubicin, Bleomycin, Mitoxantrone. Platinum-Based Agents: -contain platinum and cause cross-linking of DNA, which interferes with DNA repair and replication. Examples: Cisplatin, Carboplatin, Oxaliplatin. Many chemotherapy agents exert their effects, at least in part, by inducing oxidative stress in cancer cells. They can increase ROS levels through several mechanisms: -Direct generation of free radicals. -Disruption of mitochondrial function, leading to increased production of ROS. -Interference with the cell’s antioxidant systems. -May want to avoid antioxidants 7 days bef ore and 7 days after chemo. Examples: NAC, Glutathione, Alpha Lipoic Acid, Vitamin E -anti-oxidants known to have pro-oxidant effects (like Quercetin, Curcumin, etc.) should not be taken 2-3 days before and after chemo -pro-oxidants known to bring good benefit to chemo can be continued during chemo. Examples are: Omega 3, Aremisia Annua, Silver NanoParticles. |
| 1775- | MEL, | Chemo, | Rad, | A Systematic Review of the Chemo/Radioprotective Effects of Melatonin against Ototoxic Adverse Effects Induced by Chemotherapy and Radiotherapy |
| - | Review, | Var, | NA |
| 4353- | MF, | Chemo, | Pulsed Electromagnetic Field Enhances Doxorubicin-induced Reduction in the Viability of MCF-7 Breast Cancer Cells |
| - | in-vitro, | BC, | MCF-7 |
| 5246- | MF, | Chemo, | Non-ionizing Electromagnetic Radiation: A Study of Carcinogenic and Cancer Treatment Potential |
| - | in-vitro, | BC, | MCF-7 |
| 3492- | MFrot, | Chemo, | MF, | Synergistic Effect of Chemotherapy and Magnetomechanical Actuation of Fe-Cr-Nb-B Magnetic Particles on Cancer Cells |
| - | Human, | Lung, | NA |
| 774- | Mg, | Calc, | Chemo, | Dietary Intake of Magnesium or Calcium and Chemotherapy-Induced Peripheral Neuropathy in Colorectal Cancer Patients |
| - | Analysis, | NA, | NA |
| - | Trial, | CRC, | NA |
| 2074- | PB, | Chemo, | The effect of combined treatment with sodium phenylbutyrate and cisplatin, erlotinib, or gefitinib on resistant NSCLC cells |
| - | in-vitro, | Lung, | A549 | - | in-vitro, | Lung, | Calu-6 | - | in-vitro, | Lung, | H1650 |
| 2061- | PB, | Chemo, | Complementary effects of HDAC inhibitor 4-PB on gap junction communication and cellular export mechanisms support restoration of chemosensitivity of PDAC cells |
| - | in-vitro, | PC, | PANC1 | - | in-vitro, | PC, | COLO357 | - | in-vitro, | PC, | Bxpc-3 |
| 1669- | PBG, | Chemo, | Antioxidant and anti-inflammatory effects of oral propolis in patients with breast cancer treated with chemotherapy: a Randomized controlled trial |
| - | Trial, | BC, | NA |
| 2991- | RES, | Chemo, | Synergistic anti-cancer effects of resveratrol and chemotherapeutic agent clofarabine against human malignant mesothelioma MSTO-211H cells |
| - | in-vitro, | Melanoma, | MSTO-211H | - | in-vitro, | Nor, | MeT5A |
| 1511- | RES, | Chemo, | Combination therapy in combating cancer |
| - | Review, | NA, | NA |
| 4744- | Se, | Chemo, | antiOx, | Ingestion of selenium and other antioxidants during prostate cancer radiotherapy: A good thing? |
| - | Review, | Pca, | NA |
| 4757- | Se, | Chemo, | The protective role of selenium on the toxicity of cisplatin-contained chemotherapy regimen in cancer patients |
| - | Trial, | NA, | NA |
| 4754- | Se, | Chemo, | The effect of selenium yeast in the prevention of adverse reactions related to platinum-based combination therapy in patients with malignant tumors |
| - | Trial, | Var, | NA |
| 4755- | Se, | Chemo, | Selenium Prevention of Alopecia, Bladder and Kidney Toxicity Induced by Chemotherapeutic Agents |
| - | in-vitro, | Var, | NA |
| 4751- | Se, | Chemo, | Selenium Protects Against Toxicity Induced by Anticancer Drugs and Augments Antitumor Activity: A Highly Selective, New, and Novel Approach for the Treatment of Solid Tumors |
| - | in-vivo, | Var, | NA |
| 4749- | Se, | Chemo, | antiOx, | Selenium as an element in the treatment of ovarian cancer in women receiving chemotherapy |
| - | Trial, | Ovarian, | NA |
| 4747- | Se, | Chemo, | antiOx, | Phase I trial of selenium plus chemotherapy in gynecologic cancers |
| - | Trial, | Ovarian, | NA |
| 4752- | SeNPs, | CUR, | Chemo, | Curcumin-Modified Selenium Nanoparticles Improve S180 Tumour Therapy in Mice by Regulating the Gut Microbiota and Chemotherapy |
| - | in-vitro, | Cerv, | HeLa | - | in-vitro, | sarcoma, | S180 |
| 4745- | SeNPs, | Chemo, | Translational Selenium Nanoparticles Promotes Clinical Non-small-cell Lung Cancer Chemotherapy via Activating Selenoprotein-driven Immune Manipulation |
| - | Study, | NSCLC, | NA |
| 2552- | SFN, | Chemo, | Chemopreventive activity of sulforaphane |
| - | Review, | Var, | NA |
| 1316- | SIL, | Chemo, | Silymarin and Cancer: A Dual Strategy in Both in Chemoprevention and Chemosensitivity |
| - | Analysis, | Var, | NA |
| 3316- | SIL, | Chemo, | Silymarin Nanoparticles Counteract Cognitive Impairment Induced by Doxorubicin and Cyclophosphamide in Rats; Insights into Mitochondrial Dysfunction and Nrf2/HO-1 Axis |
| 1073- | SK, | Chemo, | Natural Compound Shikonin Is a Novel PAK1 Inhibitor and Enhances Efficacy of Chemotherapy against Pancreatic Cancer Cells |
| - | in-vitro, | PC, | PANC1 | - | in-vitro, | PC, | Bxpc-3 |
| 4753- | SSE, | Chemo, | Selenium and Lung Cancer: A Systematic Review and Meta Analysis |
| - | Review, | Lung, | NA |
| - | Trial, | GC, | NA |
| 4739- | SSE, | Chemo, | Rad, | Therapeutic Benefits of Selenium in Hematological Malignancies |
| - | Review, | Var, | NA |
| 3400- | TQ, | Chemo, | Thymoquinone Ameliorates Carfilzomib-Induced Renal Impairment by Modulating Oxidative Stress Markers, Inflammatory/Apoptotic Mediators, and Augmenting Nrf2 in Rats |
| - | in-vitro, | Nor, | NA |
| 617- | VitC, | Chemo, | The Use of Vitamin C with Chemotherapy in Cancer Treatment: An Annotated Bibliography |
| - | Review, | NA, | NA |
| 1836- | VitC, | VitK3, | Chemo, | Vitamins C and K3: A Powerful Redox System for Sensitizing Leukemia Lymphocytes to Everolimus and Barasertib |
| - | in-vitro, | AML, | NA |
| 1752- | WBV, | Chemo, | Feasibility of whole body vibration during intensive chemotherapy in patients with hematological malignancies – a randomized controlled pilot study |
| - | Trial, | Var, | NA |
Query results interpretion may depend on "conditions" listed in the research papers. Such Conditions may include : -low or high Dose -format for product, such as nano of lipid formations -different cell line effects -synergies with other products -if effect was for normal or cancerous cells
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