5LO Cancer Research Results

5LO, 5-lipoxygenase (5-LO): Click to Expand ⟱
Source:
Type:
5‑Lipoxygenase (5‑LO) is an enzyme that catalyzes the oxygenation of arachidonic acid to produce leukotrienes and other bioactive lipid mediators. It is a member of the lipoxygenase family and plays a key role in inflammatory responses.

5‑LO is overexpressed in various malignancies, particularly those with a strong inflammatory component.
Overexpression of 5‑LO is often detected in tumor cells as well as in stromal cells (e.g., tumor-associated macrophages) within the tumor microenvironment.
Elevated 5‑LO expression is frequently linked with increased tumor proliferation, enhanced angiogenesis, and higher metastatic potential—factors that often correlate with a poor prognosis.
Scientific Papers found: Click to Expand⟱
3429- TQ,    Thymoquinone exerts potent growth-suppressive activity on leukemia through DNA hypermethylation reversal in leukemia cells
- in-vitro, AML, NA - in-vivo, NA, NA
DNMT1↓, Sp1/3/4↓, NF-kB↓, Apoptosis↑, Casp↑, Bcl-xL↓, COX2/PTGS2↓, iNOS↓, 5LO↓, TNF-α↓, cycD1/CCND1↓, CompStab↝, TumCG↓,

Showing Research Papers: 51 to 51 of 51
Prev Page 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 51

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   antiOx⇅, 1,   Copper↓, 1,   GSH↓, 1,   ROS↓, 1,   ROS↑, 9,   ROS⇅, 2,   TrxR↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC2↓, 1,   CDC25↓, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 21,   AMPK↓, 1,   AMPK↑, 3,   Glycolysis↓, 2,   GSK‐3β↓, 2,   NADPH↝, 1,  

Cell Death(tgid=5) ⓘ

AIF↑, 1,   Apoptosis↑, 7,   BAX↓, 1,   BAX↑, 2,   Bax:Bcl2↑, 1,   Bcl-2↓, 4,   Bcl-xL↓, 3,   BID↓, 1,   Casp↑, 3,   Casp3↑, 6,   Casp6↑, 1,   Casp7↑, 1,   Casp8↑, 3,   Casp9↓, 1,   Casp9↑, 3,   cFLIP↓, 2,   Cyt‑c↑, 3,   Diablo↑, 1,   DR5↓, 1,   DR5↑, 2,   Fas↑, 1,   IAP1↓, 2,   IAP2/BIRC3↓, 1,   ICAD↓, 1,   iNOS↓, 3,   Mcl-1↓, 1,   p38↑, 2,   survivin↓, 5,   TRAIL↑, 1,   TumCD↓, 1,   XIAP↓, 4,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 11,   p‑Akt↓, 2,   cMET↓, 1,   EGFR↓, 2,   ERK↓, 2,   p‑ERK↓, 1,   JAK↓, 1,   JAK2↓, 1,   JNK↑, 3,   MAPK↓, 2,   MAPK↑, 1,   mTOR↓, 6,   mTORC2↓, 1,   p42↑, 1,   P70S6K↓, 1,   PI3K↓, 12,   PKCδ↓, 1,   PTEN↑, 3,   Sp1/3/4↓, 1,   STAT↓, 1,   STAT3↓, 5,  

Transcription & Epigenetics(tgid=7) ⓘ

cJun↓, 1,   cMyc↓, 4,   DNMT1↓, 3,   DNMT3A↓, 1,   FOXM1↓, 1,   FOXO↑, 2,   FOXO3↓, 1,   HATs↓, 2,   HDAC1↓, 1,   miR-200b↑, 1,   miR-200c↑, 1,   miR-21↓, 1,   Myc↓, 1,   other↓, 2,   other↑, 1,   PCAF↓, 1,   PhotoS↑, 2,   sonoS↑, 1,   SOX9↓, 1,   tumCV↓, 4,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 2,   eIF2α↓, 1,   ER Stress↑, 5,   GRP78/BiP↑, 1,   HSP70/HSPA5↓, 1,   Proteasome↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG7↑, 1,   Beclin-1/ATG6↑, 1,   LC3B↓, 1,   LC3II↑, 1,   TumAuto↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DFF45↑, 1,   DNAdam↑, 5,   p16↑, 1,   P53↑, 5,   PARP↑, 1,   cl‑PARP↑, 2,   PCNA↓, 2,   TOP2↓, 1,   UHRF1↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

p‑CDK1↓, 1,   CDK2↓, 4,   CDK4↓, 3,   CDK6↓, 2,   cycA1/CCNA1↓, 2,   CycB/CCNB1↓, 2,   cycD1/CCND1↓, 10,   CycD3↓, 1,   cycE/CCNE↓, 2,   E2Fs↓, 1,   P21↑, 5,   p27/CDKN1B↑, 3,   p‑RB1↓, 1,   Securin↓, 1,   TumCCA↑, 9,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 4,   CD133↑, 1,   cFos↓, 1,   CSCs↓, 3,   HH↓, 1,   IGF-1↓, 1,   Let-7↑, 2,   NOTCH↓, 1,   NOTCH1↓, 1,   p300↓, 1,   TumCG↓, 9,   TumCP↓, 2,   Wnt↓, 4,   Wnt↑, 1,  

Migration(tgid=13) ⓘ

AP-1↓, 1,   CA↓, 1,   Ca+2↑, 1,   cal2↓, 1,   DLC1↑, 1,   E-cadherin↑, 2,   EMT↓, 2,   FAK↓, 2,   ITGA5↓, 1,   MMP1↓, 2,   MMP2↓, 5,   MMP7↓, 2,   MMP9↓, 8,   MMPs↓, 5,   N-cadherin↓, 1,   serineP↓, 1,   Slug↓, 1,   Snail↓, 2,   TumCI↓, 4,   TumCMig↓, 3,   TumMeta↓, 2,   Twist↓, 1,   uPA↓, 1,   Vim↓, 3,   Zeb1↓, 1,   β-catenin/ZEB1↓, 4,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 9,   HIF-1↓, 1,   Hif1a↓, 1,   VEGF↓, 12,   VEGFR2/KDR/Flk1↓, 2,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   MMP↓, 3,   MPT↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX1↓, 3,   COX2/PTGS2↓, 19,   CXCL1↓, 1,   CXCR4↓, 4,   IL1↓, 3,   IL10↓, 1,   IL12↓, 2,   IL2↓, 2,   IL2↑, 1,   IL6↓, 3,   IL8↓, 2,   Imm↑, 2,   Inflam↓, 2,   MCP1/CCL2↓, 1,   NF-kB↓, 16,   NK cell↑, 3,   p65↓, 1,   PGE2↓, 6,   PSA↓, 4,   TCF↓, 1,   TLR2↓, 1,   TNF-α↓, 4,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 1,   BChE↓, 1,  

Protein Aggregation(tgid=19) ⓘ

XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 3,   PPARγ↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 2,   BioAv↑, 2,   BioAv↝, 1,   ChemoSen↑, 10,   CompStab↝, 1,   CYP1A1↓, 1,   CYP1B1↑, 1,   Dose↑, 2,   Dose↝, 1,   eff↑, 4,   eff↝, 1,   Half-Life↓, 1,   Half-Life↝, 1,   P-gp/ABCB1↓, 1,   RadioS↑, 3,   selectivity↑, 2,   Synergy↑, 5,   TET2↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AR↓, 3,   EGFR↓, 2,   FOXM1↓, 1,   IL6↓, 3,   Myc↓, 1,   PSA↓, 4,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 2,   antiNeop↑, 1,   AntiTum↑, 1,   cardioP↑, 1,   chemoP↑, 1,   chemoPv↑, 1,   hepatoP↑, 1,   OS↑, 1,   radioP↑, 1,   Risk↓, 1,   TumVol↓, 1,   TumW↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

GutMicro↑, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 1,  
Total Targets: 236

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↓, 1,   antiOx↓, 1,   antiOx↑, 18,   Catalase↑, 6,   DPPH↓, 1,   GPx↑, 3,   GPx4↑, 1,   GSH↑, 7,   GSR↑, 1,   GSTs↑, 3,   HO-1↑, 7,   lipid-P?, 1,   lipid-P↓, 8,   MDA↓, 4,   NRF2↑, 8,   RNS↓, 1,   ROS↓, 20,   SOD↑, 7,   TAC↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↓, 1,   IronCh↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12-HETE↓, 1,   5-HETE↓, 1,   5LO↓, 29,   5LO↝, 1,   ALAT↓, 1,   AMPK↑, 1,   ATP↑, 1,   cAMP↑, 1,   Eic↓, 1,   FASN↓, 1,   glucose↓, 1,   GlucoseCon↑, 1,   GSK‐3β↓, 1,   LTB4↓, 1,   LTC4↓, 1,  

Cell Death(tgid=5) ⓘ

Casp3↓, 1,   Ferroptosis↓, 1,   iNOS↓, 4,   p38↓, 2,  

Kinase & Signal Transduction(tgid=6) ⓘ

CREB↑, 1,   p‑CREB↑, 1,   EGFR↓, 1,   ERK↓, 1,   ERK↑, 1,   p‑ERK↓, 1,   p‑JNK↓, 1,   MAPK↓, 1,   PI3K↓, 1,   PKCδ↑, 1,   PP2A↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 1,   DNMT1↓, 1,   other↓, 2,   other↑, 7,   other↝, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Choline↑, 1,   IGF-1↓, 1,   IGFBP3↑, 1,   tyrosinase↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 5,   AP-1↓, 2,   Ca+2↓, 2,   Ca+2↑, 1,   EMT↓, 1,   MMP13↓, 1,   MMP2↓, 1,   MMP3↓, 2,   MMP9↓, 1,   MMPs↓, 1,   Snail↑, 1,   Twist↑, 1,   Vim↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

NO↓, 3,   NO↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 3,   GastroP↑, 1,   GLUT2↑, 1,   GLUT3↑, 1,   GLUT4↑, 1,   TRPM7↓, 1,   TRPV3↑, 1,   VGSC↓, 1,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX1↓, 3,   COX2/PTGS2↓, 16,   Eos↓, 2,   IFN-γ↑, 1,   IL1↓, 1,   IL10↑, 1,   IL12↓, 1,   IL17↓, 1,   IL1β↓, 7,   IL2↑, 1,   IL4↓, 1,   IL6↓, 12,   IL8↓, 2,   Imm↑, 6,   Imm⇅, 1,   Inflam↓, 23,   MCP1/CCL2↓, 1,   NF-kB↓, 10,   NF-kB↑, 1,   NLRP3↓, 2,   PGE2↓, 10,   PGE2↑, 1,   Th1 response↓, 1,   Th2↓, 1,   Th2↑, 2,   TLR4↓, 1,   TNF-α↓, 11,   VitD↑, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

Ach↑, 2,   AChE↓, 7,   BChE↓, 2,   BDNF↓, 1,   BDNF↑, 4,   ChAT↑, 1,   MAOA↓, 2,   MAOA↑, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 5,   BACE/β-secretase↓, 1,   p‑tau↓, 2,   XO↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   BioAv↑, 4,   BioAv⇅, 1,   BioAv↝, 2,   BioEnh↑, 2,   CompStab↝, 1,   CYP3A2↓, 1,   Dose↝, 3,   eff↑, 3,   Half-Life↓, 1,   selectivity↑, 1,   Synergy↑, 4,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   AST↓, 1,   BMD↑, 1,   BP↓, 4,   Calcium↑, 1,   CRP↓, 3,   EGFR↓, 1,   IL6↓, 12,   LDH↑, 1,   Mag↑, 1,   VitD↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   antiAll↑, 6,   AntiArt↑, 1,   AntiCan↑, 3,   AntiDiabetic↑, 4,   AntiTum↓, 1,   cardioP↑, 5,   chemoP↑, 1,   chemoPv↑, 4,   cognitive↑, 9,   hepatoP↑, 4,   memory↑, 5,   neuroP↑, 15,   Obesity↓, 1,   Pain↓, 2,   PDE4↓, 1,   radioP↑, 1,   Risk↓, 1,   toxicity↓, 5,   toxicity↝, 1,   Weight↓, 1,   Wound Healing↑, 3,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 2,   AntiFungal↑, 2,   AntiViral↑, 1,   Bacteria↓, 2,   Bacteria↑, 1,   Diar↓, 1,   GutMicro↑, 2,  
Total Targets: 177

Scientific Paper Hit Count for: 5LO, 5-lipoxygenase (5-LO)
7 Boswellia (frankincense)
4 Eugenol
4 Thymoquinone
3 Carvacrol
3 Curcumin
2 Caffeic Acid Phenethyl Ester (CAPE)
2 Echinacea
2 Fisetin
2 Garcinol
2 Piperine
2 Quercetin
1 Aloe anthraquinones
1 Bacopa monnieri
1 Boron
1 Caffeic acid
1 Thymol-Thymus vulgaris
1 Chocolate
1 CUSP9
1 Emodin
1 flavonoids
1 Ginger/6-Shogaol/Gingerol
1 Inoscavin A
1 Isoliquiritigenin
1 isoorientin
1 Methyl Jasmonate
1 Mushroom Lion’s Mane, Hericium erinaceus
1 Neem
1 Nimbolide
1 Resveratrol
1 α-Santalol/Sandalwood oil
1 Silymarin (Milk Thistle) silibinin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1090  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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