AP-1 Cancer Research Results

AP-1, Activator protein 1: Click to Expand ⟱
Source: HalifaxProj(inhibit)
Type:
Transcription factor that regulates gene expression in response to a variety of stimuli. Activator protein-1 (AP-1) is a transcription factor that consists of a diverse group of members including Jun, Fos, Maf, and ATF. AP-1 involves a number of processes such as proliferation, migration, and invasion in cells. Dysfunctional AP-1 activity is associated with cancer initiation, development, invasion, migration and drug resistance. , some small molecule inhibitors targeting AP-1 have been developed and tested, showing some anticancer effects.AP-1 has been described be overexpressed in many tumors, including triple-negative breast cancer (TNBC), colon cancer, classical Hodgkin’s disease, and anaplastic large cell lymphoma (ALCL).
Scientific Papers found: Click to Expand⟱
3595- PI,    Black pepper and health claims: a comprehensive treatise
- Review, Var, NA - Review, AD, NA
*antiOx↑, *ROS↓, *chemoP↑, TumCG↓, *cognitive↑, *MMPs↓, *PGE2↓, *AP-1↓, *5LO↓, *COX1↓, *other↑, *other↑, *other↑, *SOD↑, *Catalase↑, *GSTs↑, *GSR↑, *other↑, *Weight↓, *BioEnh↑, *BioAv↑, *Synergy↑, *CYP3A2↓, *neuroP↑, *BP↓, *other↑,
3597- PI,    Chronic diseases, inflammation, and spices: how are they linked?
- Review, AD, NA - Review, Park, NA - Review, Var, NA
*NF-kB↓, *MAPK↓, *AP-1↓, *COX2/PTGS2↓, *NOS2↓, *IL1β↓, *TNF-α↓, *PGE2↓, *STAT3↓, *IL10↑, *IL4↓, *IL5↓, P53↑, MMP9↓, MMP2↓, cMyc↓, VEGF↓, STAT3↓, survivin↓, p65↓, *antiAll↑,
2946- PL,    Piperlongumine, a potent anticancer phytotherapeutic: Perspectives on contemporary status and future possibilities as an anticancer agent
- Review, Var, NA
ROS↑, GSH↓, DNAdam↑, ChemoSen↑, RadioS↑, BioEnh↑, selectivity↑, BioAv↓, eff↑, p‑Akt↓, mTOR↓, GSK‐3β↓, β-catenin/ZEB1↓, HK2↓, Glycolysis↓, Cyt‑c↑, Casp9↑, Casp3↑, Casp7↑, cl‑PARP↑, TrxR↓, ER Stress↑, ATF4↝, CHOP/DDIT3↑, Prx4↑, NF-kB↓, cycD1/CCND1↓, CDK4↓, CDK6↓, p‑RB1↓, RAS↓, cMyc↓, TumCCA↑, selectivity↑, STAT3↓, NRF2↑, HO-1↑, PTEN↑, P-gp/ABCB1↓, MDR1↓, MRP1/ABCC1↓, survivin↓, Twist↓, AP-1↓, Sp1/3/4↓, STAT1↓, STAT6↓, SOX4↑, XBP-1↑, P21↑, eff↑, Inflam↓, COX2/PTGS2↓, IL6↓, MMP9↓, TumMeta↓, TumCI↓, ICAM-1↓, CXCR4↓, VEGF↓, angioG↓, Half-Life↝, BioAv↑,
3347- QC,    Recent Advances in Potential Health Benefits of Quercetin
- Review, Var, NA - Review, AD, NA
*antiOx↑, *ROS↓, *Inflam↓, TumCP↓, Apoptosis↑, *cardioP↑, *BP↓, TumMeta↓, MDR1↓, NADPH↓, ChemoSen↑, MMPs↓, TIMP2↑, *NLRP3↓, *IFN-γ↑, *COX2/PTGS2↓, *NF-kB↓, *MAPK↓, *CRP↓, *IL6↓, *TNF-α↓, *IL1β↓, *TLR4↑, *PKCδ↓, *AP-1↓, *ICAM-1↓, *NRF2↑, *HO-1↑, *lipid-P↓, *neuroP↑, *Synergy↑, *memory↑, *cognitive↑, *AChE↓, *BioAv↑, *BioAv↑, *BioAv↑, *BioAv↑, *BioAv↑,
894- QC,    The antioxidant, rather than prooxidant, activities of quercetin on normal cells: quercetin protects mouse thymocytes from glucose oxidase-mediated apoptosis
- in-vitro, Nor, NA
Apoptosis↑, *NF-kB↓, *AP-1↓, *P53↝, *ROS↓,
7951- RT,  BuckWS,    The anticancer potential of the dietary polyphenol rutin: Current status, challenges, and perspectives
- Review, Nor, NA
*Dose↝, *BioAv↓, *BioAv↓, *BioAv↓, *BioAv↓, *BioAv↝, TumCP↓, Risk↓, *radioP↑, chemoPv↑, TumCCA↑, GSK‐3β↑, Wnt↓, β-catenin/ZEB1↓, ROS↑, BAX↑, Casp3↑, Casp8↑, Casp9↑, PARP↑, Beclin-1/ATG6↑, ATG5↑, LC3II↑, DNMT1↓, P21↑, CDK1↑, CycB/CCNB1↓, TNF-α↑, VEGF↓, IL1β↓, NF-kB↓, AP-1↓, MYCN↓, AMPK↑, MAPK↓, PI3K↓, Akt↓, cMET↓, P-gp/ABCB1↓, MRP1/ABCC1↓, ABCG2↓, MMPs↓, TNF-α↓, iNOS↓, COX2/PTGS2↓, angioG↓, STAT3↓, *chemoP↑, *ROS↓, *MDA↓, *P53↓, *Casp3↓, *Casp9↓, *JNK↓, *TNF-α↓, *p38↓, *MAPK↓, GSH↓, ChemoSen↑, *hepatoP↑, *COX1↓, *COX2/PTGS2↓, *15-LOX/ALOX15↓, RenoP↑, *toxicity↓,
1090- SANG,    Sanguinarine inhibits invasiveness and the MMP-9 and COX-2 expression in TPA-induced breast cancer cells by inducing HO-1 expression.
- in-vitro, BC, MCF7
MMP9↓, COX2/PTGS2↓, PGE2↓, NF-kB↓, AP-1↓, p‑Akt↓, p‑ERK↓, HO-1↑,
6448- SAO,    A novel chemopreventive mechanism for a traditional medicine: East Indian sandalwood oil induces autophagy and cell death in proliferating keratinocytes
- in-vitro, Nor, HaCaT
*TumCCA↑, *AP-1↓, chemoPv↑,
3656- SFN,    Chronic diseases, inflammation, and spices: how are they linked?
- Review, AD, NA
*AntiCan↑, *cardioP↑, *NRF2↑, *Inflam↓, *NF-kB↓, *STAT3↓, *ERK↓, *MAPK↓, AP-1↑, Bcl-2↓, Casp3↑, Casp9↑,
1457- SFN,    Sulforaphane Inhibits IL-1β-Induced IL-6 by Suppressing ROS Production, AP-1, and STAT3 in Colorectal Cancer HT-29 Cells
- in-vitro, CRC, HT-29
IL6↓, ROS↓, TumCP↓, TumCI↓, p38↓, AP-1↓,
1452- SFN,    Sulforaphane Suppresses the Nicotine-Induced Expression of the Matrix Metalloproteinase-9 via Inhibiting ROS-Mediated AP-1 and NF-κB Signaling in Human Gastric Cancer Cells
- in-vitro, GC, AGS
MMP9↓, p38↓, ERK↓, AP-1↓, ROS↓, NF-kB↓, TumCI↓, MMP9↓, HDAC↓, Glycolysis↓, Hif1a↓, *memory↑, *cognitive↑,
3289- SIL,    Silymarin: a promising modulator of apoptosis and survival signaling in cancer
- Review, Var, NA
*BioAv↝, *BioAv↓, Fas↑, FasL↑, FADD↑, pro‑Casp8↑, Apoptosis↑, DR5↑, Bcl-2↑, BAX↑, Casp3↑, PI3K↓, FOXM1↓, p‑mTOR↓, p‑P70S6K↓, Hif1a↓, Akt↑, angioG↓, STAT3↓, NF-kB↓, lipid-P↓, Synergy↑, CDK1↓, survivin↓, CycB/CCNB1↓, Mcl-1↓, Casp9↑, AP-1↓, BioAv↑,
978- SIL,    A comprehensive evaluation of the therapeutic potential of silibinin: a ray of hope in cancer treatment
- Review, Var, NA
PI3K↓, Akt↓, NF-kB↓, Wnt/(β-catenin)↓, MAPK↓, TumCP↓, TumCCA↑, Apoptosis↑, p‑EGFR↓, JAK2↓, STAT5↓, cycD1/CCND1↓, hTERT/TERT↓, AP-1↓, MMP9↓, miR-21↓, miR-155↓, Casp9↑, BID↑, ERK↓, Akt2↓, DNMT1↓, P53↑, survivin↓, Casp3↑, ROS↑,
1191- SM,    Salvia miltiorrhiza extract inhibits TPA‑induced MMP‑9 expression and invasion through the MAPK/AP‑1 signaling pathw
- in-vitro, BC, MCF7
Inflam↓, MMP9↓, TumCI↓, AP-1↓, lipidLev↓,
3427- TQ,    Chemopreventive and Anticancer Effects of Thymoquinone: Cellular and Molecular Targets
- in-vitro, Var, NA
ROS⇅, Fas↑, DR5↑, TRAIL↑, Casp3↑, Casp8↑, Casp9↑, P53↑, mTOR↓, Bcl-2↓, BID↓, CXCR4↓, JNK↑, p38↑, MAPK↑, LC3II↑, ATG7↑, Beclin-1/ATG6↑, AMPK↑, PPARγ↑, eIF2α↓, P70S6K↓, VEGF↓, ERK↓, NF-kB↓, XIAP↓, survivin↓, p65↓, DLC1↑, FOXO↑, TET2↑, CYP1B1↑, UHRF1↓, DNMT1↓, HDAC1↓, IL2↑, IL1↓, IL6↓, IL10↓, IL12↓, TNF-α↓, iNOS↓, COX2/PTGS2↓, 5LO↓, AP-1↓, PI3K↓, Akt↓, cMET↓, VEGFR2/KDR/Flk1↓, CXCL1↓, ITGA5↓, Wnt↓, β-catenin/ZEB1↓, GSK‐3β↓, Myc↓, cycD1/CCND1↓, N-cadherin↓, Snail↓, Slug↓, Vim↓, Twist↓, Zeb1↓, MMP2↓, MMP7↓, MMP9↓, JAK2↓, STAT3↓, NOTCH↓, cycA1/CCNA1↓, CDK2↓, CDK4↓, CDK6↓, CDC2↓, CDC25↓, Mcl-1↓, E2Fs↓, p16↑, p27/CDKN1B↑, P21↑, ChemoSen↑,
1310- UA,    Ursolic acid triggers apoptosis and Bcl-2 downregulation in MCF-7 breast cancer cells
- in-vitro, BC, MCF7
GR↝, AP-1↝, cl‑PARP↑, Bcl-2↓,
3112- VitC,    Antioxidative and Anti-Inflammatory Activity of Ascorbic Acid
- Review, Nor, NA
*ROS↓, *antiOx↑, *SOD↑, *Catalase↑, *GPx↑, *NRF2↑, *AP-1↑, *Inflam↓, *CRP↓, IFN-γ↓,

Showing Research Papers: 51 to 67 of 67
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 67

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

ARE↑, 1,   Fenton↑, 2,   GPx4↓, 2,   GSH↓, 3,   GSR↑, 1,   H2O2↑, 1,   HNE↑, 1,   HO-1↑, 7,   Iron↑, 2,   lipid-P↓, 3,   lipid-P↑, 2,   MDA↑, 1,   NADH↓, 1,   NQO1↑, 2,   NRF2↓, 3,   NRF2↑, 7,   NRF2↝, 1,   Prx4↑, 1,   ROS↓, 6,   ROS↑, 22,   ROS⇅, 1,   ROS↝, 1,   i-ROS↓, 1,   mt-ROS↑, 1,   Trx↑, 1,   TrxR↓, 1,   TrxR↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↑, 1,   CDC2↓, 2,   CDC25↓, 2,   compI↓, 1,   compIII↓, 1,   EGF↓, 1,   ETC↓, 2,   mitResp↓, 1,   mtDam↑, 2,   OCR↓, 1,   OXPHOS↓, 1,   SIRT3↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 1,   AMPK↑, 5,   ATP↓, 1,   cAMP↓, 1,   FASN↓, 1,   G6PD↓, 1,   GLS↓, 1,   GlucoseCon↓, 2,   GlutMet↓, 1,   Glycolysis↓, 4,   GSK‐3β↓, 2,   GSK‐3β↑, 1,   HK2↓, 2,   lactateProd↓, 1,   lactateProd↑, 1,   LDHA↓, 2,   lipidLev↓, 1,   NADPH↓, 1,   NADPH↑, 1,   PDK1 / PDPK1↓, 2,   PKM2↓, 1,   SCD1↓, 1,   SREBP2↓, 1,   TCA↓, 1,   Warburg↓, 1,  

Cell Death(tgid=5) ⓘ

AIF↑, 2,   Apoptosis↑, 16,   Apoptosis↝, 1,   Bak↑, 3,   BAX↑, 12,   BAX⇅, 1,   BAX↝, 1,   Bax:Bcl2↑, 1,   Bcl-2↓, 12,   Bcl-2↑, 1,   Bcl-2↝, 1,   Bcl-xL↓, 5,   Bcl-xL↝, 1,   BID↓, 1,   BID↑, 3,   p‑BID↓, 1,   BIM↑, 4,   Casp↑, 6,   Casp3↓, 1,   Casp3↑, 13,   Casp3↝, 1,   cl‑Casp3↑, 2,   Casp7↑, 3,   Casp8↑, 5,   pro‑Casp8↑, 1,   Casp9↑, 11,   cl‑Casp9↑, 2,   Cyt‑c↑, 7,   Cyt‑c↝, 1,   Diablo↑, 2,   DR5↑, 5,   FADD↑, 1,   Fas?, 1,   Fas↑, 3,   FasL↑, 1,   Ferroptosis↑, 2,   HEY1↓, 1,   iNOS↓, 3,   Mcl-1↓, 5,   p‑Mcl-1↓, 1,   MDM2↓, 1,   MDM2↑, 1,   NOXA↑, 1,   p38↓, 4,   p38↑, 4,   PUMA↑, 1,   survivin↓, 10,   TRAIL↑, 2,   TumCD↑, 1,   XIAP↓, 4,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 20,   Akt↑, 1,   Akt↝, 1,   p‑Akt↓, 6,   Akt2↓, 1,   cMET↓, 3,   EGFR↓, 6,   EGFR↝, 1,   p‑EGFR↓, 1,   ERK↓, 11,   ERK↑, 2,   p‑ERK↓, 1,   p‑ERK↑, 1,   HER2/EBBR2↓, 1,   HGF/c-Met↓, 1,   IGF-1R↓, 1,   IGFR↓, 1,   IKKα↓, 1,   JAK↓, 1,   JAK2↓, 2,   JAK3↓, 1,   JNK↓, 6,   JNK↑, 3,   JNK↝, 1,   p‑JNK↓, 1,   MAPK↓, 6,   MAPK↑, 5,   mTOR↓, 10,   mTOR↝, 1,   p‑mTOR↓, 2,   mTORC2↓, 1,   P70S6K↓, 1,   p‑P70S6K↓, 1,   PDGFR-BB↓, 1,   PDGFR-BB↑, 1,   PI3K↓, 16,   PI3K↝, 1,   PKCδ↓, 1,   PTEN↑, 3,   PTEN↝, 1,   Raf↓, 1,   RAS↓, 1,   RET↓, 1,   Sp1/3/4↓, 6,   STAT↓, 1,   STAT3↓, 18,   STAT5↓, 1,   STAT6↓, 1,   TSC2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF3↑, 1,   ATF4↑, 3,   ATF4↝, 1,   CBP↓, 1,   cJun↓, 2,   p‑cJun↓, 1,   cMyc↓, 5,   DNMT1↓, 4,   DNMTs↓, 4,   EZH2↓, 1,   FOXM1↓, 1,   FOXO↓, 1,   FOXO↑, 2,   FOXO1↓, 1,   FOXO3↓, 1,   FOXO3↑, 1,   H3↑, 1,   HATs↓, 1,   HDAC↓, 7,   HDAC1↓, 1,   HDAC4↓, 1,   miR-107↑, 1,   miR-139-5p↑, 1,   miR-155↓, 2,   miR-21↓, 2,   miR-224↓, 1,   miR-340↓, 1,   miR-34a↑, 1,   miR-422a↑, 1,   Myc↓, 1,   MYCN↓, 1,   OCT4↓, 2,   SOX2↓, 2,   SOX4↑, 1,   SUZ12↓, 1,   TCF-4↓, 2,   tumCV↓, 2,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 4,   eIF2α↓, 2,   ER Stress↓, 1,   ER Stress↑, 5,   GRP78/BiP↑, 3,   HSF1↓, 1,   HSP27↓, 1,   HSP90↓, 3,   IRE1↑, 2,   XBP-1↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 1,   ATG7↑, 2,   Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 3,   LC3II↑, 3,   TumAuto↑, 4,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 1,   p‑BRCA1↑, 1,   DNAdam↑, 7,   hTERT/TERT↓, 3,   p16↑, 2,   P53?, 1,   P53↑, 11,   P53↝, 1,   PARP↑, 3,   cl‑PARP↑, 4,   cl‑PARP1↑, 1,   PCNA↓, 2,   Telomerase↓, 3,   TOP1↓, 1,   TOP2↓, 2,   UHRF1↓, 1,   γH2AX↑, 3,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 3,   CDK1↑, 1,   CDK2↓, 8,   CDK4↓, 10,   p‑CDK4↓, 1,   CDK6↓, 5,   CHK1↓, 1,   Chk2↓, 1,   Cyc↝, 1,   cycA1/CCNA1↓, 2,   CycB/CCNB1↓, 4,   cycD1/CCND1↓, 8,   cycD1/CCND1↝, 1,   p‑cycD1/CCND1↓, 1,   cycE/CCNE↓, 7,   E2Fs↓, 2,   Ki-67↓, 2,   P21↑, 13,   P21↝, 1,   p27/CDKN1B↑, 5,   pRB↑, 1,   p‑RB1↓, 2,   TumCCA↑, 22,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH1A1↓, 1,   BMI1↓, 1,   CD24↓, 1,   cFos↓, 2,   p‑cFos↓, 1,   CSCs↓, 4,   Gli1↓, 1,   HH↓, 1,   Ki-67↓, 2,   mTORC1↓, 1,   Nanog↓, 3,   NOTCH↓, 3,   NOTCH1↓, 1,   NOTCH1↝, 1,   NOTCH2↑, 1,   Smo↓, 1,   STAT1↓, 2,   TumCG↓, 7,   TumCP↓, 15,   Wnt↓, 9,   Wnt/(β-catenin)↓, 1,  

Migration(tgid=13) ⓘ

AP-1↓, 40,   AP-1↑, 4,   AP-1↝, 3,   Ca+2↓, 1,   Ca+2↑, 1,   Cdc42↑, 1,   COL1↓, 1,   DLC1↑, 1,   E-cadherin↑, 5,   EMT↓, 9,   FAK↓, 2,   ITGA5↓, 1,   MMP16↓, 1,   MMP2↓, 16,   MMP2↝, 1,   MMP3↓, 1,   MMP7↓, 4,   MMP9↓, 27,   MMPs↓, 7,   N-cadherin↓, 2,   NFAT↑, 1,   PDGF↓, 2,   Rho↓, 1,   Slug↓, 2,   Snail↓, 3,   TGF-β↓, 1,   TIMP1↑, 2,   TIMP2↓, 1,   TIMP2↑, 3,   TumCA↓, 1,   TumCI↓, 11,   TumCMig↓, 4,   TumMeta↓, 11,   TumMeta↑, 2,   Twist↓, 3,   uPA↓, 8,   Vim↓, 4,   Zeb1↓, 2,   β-catenin/ZEB1↓, 13,   β-catenin/ZEB1↝, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 8,   CD31/PECAM-1↓, 1,   Hif1a↓, 8,   Hif1a↝, 1,   NO↑, 1,   VEGF↓, 15,   VEGF↝, 1,   VEGFR2/KDR/Flk1↓, 2,  

Barriers & Transport(tgid=15) ⓘ

GLUT1↓, 2,   MMP↓, 7,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD44↓, 1,   CD59↑, 1,   COX2/PTGS2↓, 15,   COX2/PTGS2↑, 1,   COX2/PTGS2↝, 1,   CXCL1↓, 1,   CXCR4↓, 3,   DR4↑, 1,   ICAM-1↓, 1,   IFN-γ↓, 2,   IL1↓, 1,   IL10↓, 1,   IL10↑, 1,   IL12↓, 1,   IL1β↓, 3,   IL2↓, 1,   IL2↑, 1,   IL4↑, 1,   IL6↓, 4,   IL6↝, 1,   IL8↓, 1,   Imm↑, 1,   Inflam↓, 3,   MCT1↓, 1,   NF-kB↓, 34,   NF-kB↝, 1,   NK cell↑, 1,   p65↓, 2,   PGE2↓, 3,   PSA↝, 1,   TNF-α↓, 9,   TNF-α↑, 1,   TNF-α↝, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 4,   AR↝, 1,   ER-α36↓, 1,   GR↝, 1,   PPARα↝, 1,   cl‑PPARα↓, 1,   PPARγ↑, 1,   SXR↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 1,   BioAv↓, 4,   BioAv↑, 5,   BioAv↝, 1,   BioEnh↑, 1,   ChemoSen↑, 15,   CompStab↓, 1,   CYP1A1↓, 1,   CYP1B1↑, 1,   CYP3A4↓, 1,   Dose↑, 1,   Dose↝, 1,   eff↓, 2,   eff↑, 7,   Half-Life↓, 2,   Half-Life↝, 1,   MDR1↓, 3,   MRP1/ABCC1↓, 2,   P-gp/ABCB1↓, 5,   P450↓, 1,   RadioS↑, 6,   selectivity?, 1,   selectivity↑, 8,   selectivity↝, 1,   Synergy↑, 15,   TET2↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AR↓, 4,   AR↝, 1,   p‑BRCA1↑, 1,   E6↓, 2,   E7↓, 2,   EGFR↓, 6,   EGFR↝, 1,   p‑EGFR↓, 1,   EZH2↓, 1,   FOXM1↓, 1,   HER2/EBBR2↓, 1,   hTERT/TERT↓, 3,   IL6↓, 4,   IL6↝, 1,   Myc↓, 1,   PSA↝, 1,   SUZ12↓, 1,   TF-Ag↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 2,   AntiTum↑, 1,   chemoP↑, 3,   chemoPv↑, 5,   OS↑, 1,   RenoP↑, 2,   Risk↓, 3,   TumVol↓, 1,   TumVol∅, 1,   TumW↓, 1,   TumW∅, 1,  

Infection & Microbiome(tgid=24) ⓘ

GutMicro↑, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,   Ingr↝, 1,  
Total Targets: 426

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx?, 1,   antiOx↑, 13,   Catalase↑, 6,   GPx↑, 5,   GSH↑, 5,   GSR↑, 1,   GSTs↑, 3,   H2O2↓, 1,   HDL↓, 1,   HO-1↑, 4,   lipid-P↓, 4,   MDA↓, 3,   NRF2↑, 7,   Prx↑, 2,   RNS↓, 1,   ROS?, 1,   ROS↓, 19,   ROS⇅, 1,   SOD↑, 7,   SOD1↑, 2,   SOD2↑, 2,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

15-LOX/ALOX15↓, 1,   5LO↓, 2,   AMPK↑, 1,   cAMP↑, 1,   GSK‐3β↓, 1,   LDL↓, 1,   NADPH↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 1,   Casp3?, 1,   Casp3↓, 2,   Casp9↓, 1,   iNOS↓, 3,   p38↓, 1,   p‑p38↓, 2,  

Kinase & Signal Transduction(tgid=6) ⓘ

ERK↓, 3,   p‑ERK↓, 1,   IGF-1R↓, 1,   JAK↓, 1,   JNK↓, 2,   p‑JNK↓, 2,   MAPK↓, 6,   p‑MKK4↑, 1,   PDGFR-BB↓, 1,   PI3K↓, 1,   PKCδ↓, 1,   STAT3↓, 3,   STAT5↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 1,   cJun↓, 1,   p‑cJun↓, 1,   HATs↓, 1,   HDAC↑, 1,   other↓, 1,   other↑, 6,   other↝, 2,  

Protein Folding & ER Stress(tgid=8) ⓘ

HSP70/HSPA5↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 1,   DNArepair↑, 1,   P53↓, 2,   P53↝, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

E2Fs↑, 1,   TumCCA↑, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 2,   AP-1↓, 19,   AP-1↑, 1,   MMP1↓, 1,   MMP13↓, 1,   MMP2↓, 1,   MMP9↓, 2,   MMPs↓, 1,   TGF-β↓, 1,   α-SMA↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

LOX1↓, 1,   NO↓, 2,   VEGF↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 3,   GastroP↑, 1,   MMP↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD19↑, 1,   CD4+↑, 1,   COX1↓, 4,   COX2/PTGS2↓, 12,   ICAM-1↓, 2,   IFN-γ↓, 1,   IFN-γ↑, 1,   IL10↑, 3,   IL17↓, 1,   IL1β↓, 6,   IL23↓, 1,   IL4↓, 1,   IL4↑, 1,   IL5↓, 1,   IL6↓, 7,   IL8↓, 2,   Imm↑, 2,   Inflam↓, 18,   Inflam↑, 1,   MCP1/CCL2↓, 1,   NF-kB↓, 15,   NK cell↑, 1,   NLRP3↓, 2,   PGE2↓, 5,   TLR4↓, 3,   TLR4↑, 1,   TNF-α↓, 9,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 2,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 3,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 10,   BioAv↑, 9,   BioAv↝, 5,   BioEnh↑, 2,   CYP3A2↓, 1,   Dose↝, 6,   Dose∅, 1,   Half-Life↝, 2,   P450↓, 1,   Synergy↑, 3,  

Clinical Biomarkers(tgid=22) ⓘ

BloodF↑, 1,   BP↓, 2,   creat↓, 1,   CRP↓, 2,   IL6↓, 7,   NOS2↓, 1,  

Functional Outcomes(tgid=23) ⓘ

antiAll↑, 3,   AntiArt↑, 1,   AntiCan↑, 6,   AntiDiabetic↓, 1,   AntiDiabetic↑, 2,   cardioP↑, 7,   chemoP↑, 3,   cognitive↑, 6,   cough?, 1,   hepatoP↓, 1,   hepatoP↑, 7,   memory↑, 3,   neuroP↑, 9,   radioP↑, 2,   RenoP↑, 3,   SoreThr?, 1,   toxicity↓, 3,   toxicity↝, 3,   toxicity∅, 1,   Weight↓, 1,   Wound Healing↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 2,   AntiViral↑, 2,   Bacteria↓, 2,   GutMicro↑, 1,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 2,  
Total Targets: 152

Scientific Paper Hit Count for: AP-1, Activator protein 1
8 Curcumin
5 EGCG (Epigallocatechin Gallate)
4 Sulforaphane (mainly Broccoli)
3 Kaempferol
3 Piperine
2 Artemisinin
2 Ashwagandha(Withaferin A)
2 Copper and Cu NanoParticles
2 Ursolic acid
2 Fisetin
2 Phenethyl isothiocyanate
2 Luteolin
2 Propolis -bee glue
2 Quercetin
2 Silymarin (Milk Thistle) silibinin
1 Allicin (mainly Garlic)
1 Radiotherapy/Radiation
1 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
1 Anethole/trans-Anethole
1 Berberine
1 Black Rice, Oryza sativa
1 Cat’s Claw
1 Chrysin
1 Cinnamon
1 D-limonene
1 Formononetin
1 Bortezomib
1 Ginkgo biloba
1 Genistein (soy isoflavone)
1 Inositol
1 Isothiocyanates
1 Allyl isothiocyanate
1 Benzyl isothiocyanate
1 Licochalcone A
1 Licorice
1 Lycopene
1 Morin
1 Nimbolide
1 Phycocyanin
1 Piperlongumine
1 Rutin
1 buckwheat sprouts
1 Sanguinarine
1 α-Santalol/Sandalwood oil
1 Salvia miltiorrhiza
1 Thymoquinone
1 Vitamin C (Ascorbic Acid)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:11  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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