AP-1 Cancer Research Results

AP-1, Activator protein 1: Click to Expand ⟱
Source: HalifaxProj(inhibit)
Type:
Transcription factor that regulates gene expression in response to a variety of stimuli. Activator protein-1 (AP-1) is a transcription factor that consists of a diverse group of members including Jun, Fos, Maf, and ATF. AP-1 involves a number of processes such as proliferation, migration, and invasion in cells. Dysfunctional AP-1 activity is associated with cancer initiation, development, invasion, migration and drug resistance. , some small molecule inhibitors targeting AP-1 have been developed and tested, showing some anticancer effects.AP-1 has been described be overexpressed in many tumors, including triple-negative breast cancer (TNBC), colon cancer, classical Hodgkin’s disease, and anaplastic large cell lymphoma (ALCL).
Scientific Papers found: Click to Expand⟱
1310- UA,    Ursolic acid triggers apoptosis and Bcl-2 downregulation in MCF-7 breast cancer cells
- in-vitro, BC, MCF-7
GR↝, AP-1↝, cl‑PARP↑, Bcl-2↓,
3112- VitC,    Antioxidative and Anti-Inflammatory Activity of Ascorbic Acid
- Review, Nor, NA
*ROS↓, *antiOx↑, *SOD↑, *Catalase↑, *GPx↑, *NRF2↑, *AP-1↑, *Inflam↓, *CRP↓, IFN-γ↓,

Showing Research Papers: 51 to 52 of 52
Prev Page 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 52

Pathway results for Effect on Cancer / Diseased Cells:


Cell Death ⓘ

Bcl-2↓, 1,  

DNA Damage & Repair ⓘ

cl‑PARP↑, 1,  

Migration ⓘ

AP-1↝, 1,  

Immune & Inflammatory Signaling ⓘ

IFN-γ↓, 1,  

Hormonal & Nuclear Receptors ⓘ

GR↝, 1,  
Total Targets: 5

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,   Catalase↑, 1,   GPx↑, 1,   NRF2↑, 1,   ROS↓, 1,   SOD↑, 1,  

Migration ⓘ

AP-1↑, 1,  

Immune & Inflammatory Signaling ⓘ

CRP↓, 1,   Inflam↓, 1,  

Clinical Biomarkers ⓘ

CRP↓, 1,  
Total Targets: 10

Scientific Paper Hit Count for: AP-1, Activator protein 1
8 Curcumin
5 EGCG (Epigallocatechin Gallate)
3 Piperine
3 Sulforaphane (mainly Broccoli)
2 Artemisinin
2 Ashwagandha(Withaferin A)
2 Copper and Cu NanoParticles
2 Ursolic acid
2 Fisetin
2 Propolis -bee glue
2 Quercetin
2 Silymarin (Milk Thistle) silibinin
1 Allicin (mainly Garlic)
1 Radiotherapy/Radiation
1 Anethole/trans-Anethole
1 Berberine
1 Cat’s Claw
1 Chrysin
1 Cinnamon
1 D-limonene
1 Genistein (soy isoflavone)
1 Luteolin
1 Lycopene
1 Nimbolide
1 Phenethyl isothiocyanate
1 Piperlongumine
1 Sanguinarine
1 α-Santalol/Sandalwood oil
1 Salvia miltiorrhiza
1 Thymoquinone
1 Vitamin C (Ascorbic Acid)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:11  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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