FAK Cancer Research Results

FAK, FAK signaling: Click to Expand ⟱
Source: HalifaxProj(inhibit)
Type:
FAK (Focal Adhesion Kinase) is a non-receptor tyrosine kinase that plays a crucial role in cellular processes such as adhesion, migration, proliferation, and survival. It is primarily localized at focal adhesions, where it interacts with integrins and other signaling molecules. FAK promotes cell proliferation by activating signaling pathways such as the PI3K/Akt and MAPK/ERK pathways. These pathways are often upregulated in cancer cells, leading to uncontrolled growth.
Scientific Papers found: Click to Expand⟱
3425- TQ,    Advances in research on the relationship between thymoquinone and pancreatic cancer
Apoptosis↑, TumCP↓, TumCI↓, TumMeta↓, ChemoSen↑, angioG↓, Inflam↓, NF-kB↓, PI3K↓, Akt↓, TGF-β↓, Jun↓, p38↑, MAPK↑, MMP9↓, PKM2↓, ROS↑, JNK↑, MUC4↓, TGF-β↑, Dose↝, FAK↓, NOTCH↓, PTEN↑, mTOR↓, Warburg↓, XIAP↓, COX2↓, Casp9↑, Ki-67↓, CD34↓, VEGF↓, MCP1↓, survivin↓, Cyt‑c↑, Casp3↑, H4↑, HDAC↓,
3423- TQ,    Epigenetic role of thymoquinone: impact on cellular mechanism and cancer therapeutics
- Review, Var, NA
AntiCan↑, Inflam↓, hepatoP↑, RenoP↑, BAX↑, Bak↑, Bcl-2↓, Bcl-xL↓, ROS↑, P53↑, PTEN↑, P21↑, p27↑, BRCA1↑, PI3K↓, Akt↓, MAPK↓, ERK↓, p‑ERK↓, MMPs↓, FAK↓, Twist↓, Zeb1↓, EMT↓, TumMeta↓, angioG↓, VEGF↓, HDAC↓, Maspin↑, SIRT1↑, DNMT1↓, DNMT3A↓, HDAC1↓, HDAC4↓,

Showing Research Papers: 51 to 52 of 52
Prev Page 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 52

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ROS↑, 2,  

Mitochondria & Bioenergetics ⓘ

XIAP↓, 1,  

Core Metabolism/Glycolysis ⓘ

PKM2↓, 1,   SIRT1↑, 1,   Warburg↓, 1,  

Cell Death ⓘ

Akt↓, 2,   Apoptosis↑, 1,   Bak↑, 1,   BAX↑, 1,   Bcl-2↓, 1,   Bcl-xL↓, 1,   Casp3↑, 1,   Casp9↑, 1,   Cyt‑c↑, 1,   JNK↑, 1,   MAPK↓, 1,   MAPK↑, 1,   p27↑, 1,   p38↑, 1,   survivin↓, 1,  

Transcription & Epigenetics ⓘ

H4↑, 1,  

DNA Damage & Repair ⓘ

BRCA1↑, 1,   DNMT1↓, 1,   DNMT3A↓, 1,   P53↑, 1,  

Cell Cycle & Senescence ⓘ

P21↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

CD34↓, 1,   EMT↓, 1,   ERK↓, 1,   p‑ERK↓, 1,   HDAC↓, 2,   HDAC1↓, 1,   HDAC4↓, 1,   Jun↓, 1,   mTOR↓, 1,   NOTCH↓, 1,   PI3K↓, 2,   PTEN↑, 2,  

Migration ⓘ

FAK↓, 2,   Ki-67↓, 1,   MMP9↓, 1,   MMPs↓, 1,   MUC4↓, 1,   TGF-β↓, 1,   TGF-β↑, 1,   TumCI↓, 1,   TumCP↓, 1,   TumMeta↓, 2,   Twist↓, 1,   Zeb1↓, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 2,   VEGF↓, 2,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   Inflam↓, 2,   MCP1↓, 1,   NF-kB↓, 1,  

Drug Metabolism & Resistance ⓘ

ChemoSen↑, 1,   Dose↝, 1,  

Clinical Biomarkers ⓘ

BRCA1↑, 1,   Ki-67↓, 1,   Maspin↑, 1,  

Functional Outcomes ⓘ

AntiCan↑, 1,   hepatoP↑, 1,   RenoP↑, 1,  
Total Targets: 64

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: FAK, FAK signaling
6 Apigenin (mainly Parsley)
4 Curcumin
3 Chrysin
3 Propolis -bee glue
3 Luteolin
2 Betulinic acid
2 EGCG (Epigallocatechin Gallate)
2 Fisetin
2 Lycopene
2 Magnetic Fields
2 Magnetic Field Rotating
2 Quercetin
2 Resveratrol
2 Shikonin
2 Thymoquinone
1 Allicin (mainly Garlic)
1 Alpha-Lipoic-Acid
1 alpha Linolenic acid
1 Baicalein
1 Berberine
1 Bruteridin(bergamot juice)
1 Capsaicin
1 methylseleninic acid
1 Ellagic acid
1 Garcinol
1 Graviola
1 Phenylbutyrate
1 Phenethyl isothiocyanate
1 Psoralidin
1 Pterostilbene
1 Kaempferol
1 raloxifen
1 tamoxifen
1 Genistein (soy isoflavone)
1 Sulforaphane (mainly Broccoli)
1 Silymarin (Milk Thistle) silibinin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:110  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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