neuroP Cancer Research Results

neuroP, neuroprotective: Click to Expand ⟱
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Neuroprotective refers to the ability of a substance, intervention, or strategy to preserve the structure and function of nerve cells (neurons) against injury or degeneration.
-While cancer and neurodegenerative processes might seem distinct, there is significant overlap in terms of treatment-related neurotoxicity, shared molecular mechanisms, and the potential for therapies that provide neuroprotection during cancer treatment.
Scientific Papers found: Click to Expand⟱
3667- ART/DHA,    Artemisinin improves neurocognitive deficits associated with sepsis by activating the AMPK axis in microglia
- Review, Sepsis, NA
*cognitive↑, *neuroP↑, *TNF-α↓, *IL6↓, *NF-kB↓, *AMPK↑, *ROS↓, *Akt↑, *MCP1/CCL2↓, *MIP2↓, *TGF-β↑, *Inflam↓,
4278- ART/DHA,    Artemisinin Ameliorates the Neurotoxic Effect of 3-Nitropropionic Acid: A Possible Involvement of the ERK/BDNF/Nrf2/HO-1 Signaling Pathway
- in-vivo, NA, NA
*IL6↓, *Casp3↓, *Casp9↓, *BDNF↑, *ERK↑, *NRF2↑, *HO-1↑, *neuroP↑, *antiOx↑, *Inflam↓,
3675- Ash,    Ashwagandha (Withania somnifera) Reverses β-Amyloid1-42 Induced Toxicity in Human Neuronal Cells: Implications in HIV-Associated Neurocognitive Disorders (HAND)
*memory↑, *neuroP↑, *Aβ↓, *LDH↓, *PPARγ↑, *cognitive↑,
3670- Ash,    Neurodegenerative diseases and Withania somnifera (L.): An update
- Review, AD, NA - Review, Park, NA
*Apoptosis↓, *Inflam↓, *ROS↓, *neuroP↑,
3674- Ash,    Ashwagandha in brain disorders: A review of recent developments
- Review, NA, NA
*neuroP↑,
3687- Ash,    Role of Withaferin A and Its Derivatives in the Management of Alzheimer’s Disease: Recent Trends and Future Perspectives
- Review, AD, NA
*Aβ↓, *tau↓, *HSPs↝, *antiOx↑, *ROS↓, *Inflam↓, *neuroP↑, *cognitive↑, *NF-kB↓, *HO-1↑, *memory↑, *AChE↓, *BChE↓, *ChAT↑, *Ach↑,
3688- Ash,    Withaferin A Suppresses Beta Amyloid in APP Expressing Cells: Studies for Tat and Cocaine Associated Neurological Dysfunctions
- NA, AD, SH-SY5Y
*Aβ↓, *neuroP↑,
3672- Ash,    Critical review of the Withania somnifera (L.) Dunal: ethnobotany, pharmacological efficacy, and commercialization significance in Africa
- Review, NA, NA
*cardioP↑, *antiOx↑, *ROS↓, *neuroP↑, *Inflam↓, *Apoptosis↓,
3159- Ash,    Neuroprotective effects of Withania somnifera in the SH-SY5Y Parkinson cell model
- in-vitro, Park, SH-SY5Y
*neuroP↑, *Inflam↓, *ROS↓, *cognitive↑, *memory↑, *GPx↑, *Prx↓, *ATP↑, *Vim↓, *mtDam↓,
3161- Ash,    Withaferin A inhibits ferroptosis and protects against intracerebral hemorrhage
- in-vivo, Stroke, NA
*neuroP↑, *MDA↓, *ROS↓, *SOD↑, *GPx↑, *NRF2↑, *HO-1↑,
3166- Ash,    Exploring the Multifaceted Therapeutic Potential of Withaferin A and Its Derivatives
- Review, Var, NA
*p‑PPARγ↓, *cardioP↑, *AMPK↑, *BioAv↝, *Half-Life↝, *Half-Life↝, *Dose↑, *chemoPv↑, IL6↓, STAT3↓, ROS↓, OXPHOS↓, PCNA↓, LDH↓, AMPK↑, TumCCA↑, NOTCH3↓, Akt↓, Bcl-2↓, Casp3↑, Apoptosis↑, eff↑, NF-kB↓, CSCs↓, HSP90↓, PI3K↓, FOXO3↑, β-catenin/ZEB1↓, N-cadherin↓, EMT↓, FASN↓, ACLY↓, ROS↑, NRF2↑, HO-1↑, NQO1↑, JNK↑, mTOR↓, neuroP↑, *TNF-α↓, *IL1β↓, *IL6↓, *IL8↓, *IL18↓, RadioS↑, eff↑,
4303- Ash,    Ashwagandha (Withania somnifera)—Current Research on the Health-Promoting Activities: A Narrative Review
- Review, AD, NA
*neuroP↑, *Sleep↑, *Inflam↓, *cardioP↑, *cognitive↑, *Aβ↓, *TNF-α↓, *IL1β↓, *IL6↓, *MCP1/CCL2↓, *lipid-P↓, *tau↓, *ROS↓, *BBB↑, *AChE↓, *GSH↑, *GSTs↑, *GSR↑, *GPx↑, *SOD↑, *Catalase↑, ChemoSen↑, *Strength↑,
4814- ASTX,    Chemopreventive and therapeutic efficacy of astaxanthin against cancer: A comprehensive review
- Review, Var, NA
Apoptosis↑, EMT↓, AntiCan↑, *cardioP↑, *neuroP↑, TumCG↓, *antiOx↑, *Bacteria↓, *Imm↑, *hepatoP↑, *AntiDiabetic↑, ROS↓, *chemoPv↑,
4804- ASTX,    Astaxanthin in cancer therapy and prevention (Review)
- Review, Var, NA - Review, AD, NA
*antiOx↑, *Inflam↓, ChemoSen⇅, chemoP↑, BioAv↑, TumCP↑, ROS⇅, Apoptosis↑, PI3K↑, Akt↑, GSK‐3β↑, NRF2↑, AntiCan↑, *neuroP↑, eff↑, AntiTum↑,
4813- ASTX,    Astaxanthin Prevents Oxidative Damage and Cell Apoptosis Under Oxidative Stress Involving the Restoration of Mitochondrial Function
- in-vitro, AD, NA
*antiOx↑, *Apoptosis↓, *AntiTum↑, *ROS↓, *MMP↑, *neuroP↑,
4807- ASTX,    An overview of the anticancer activity of astaxanthin and the associated cellular and molecular mechanisms
- Review, Var, NA
*antiOx↑, *neuroP↑, AntiCan↑, TumCG↓, TumCD↑, TumCMig↓, ChemoSen↑, chemoP↑, *BioAv↓, TumCP↓, TumCCA↑, Apoptosis↑, BioAv↑,
5425- ASTX,    Multiple roles of fucoxanthin and astaxanthin against Alzheimer's disease: Their pharmacological potential and therapeutic insights
- in-vivo, AD, NA
*neuroP↑, *antiOx↑, *Inflam↑, *AChE↓, *BACE/β-secretase↓, *MAOA↓, *Aβ↓, *memory↑, *MDA↓, *SOD↑, *NRF2↑, *HO-1↑, *NF-kB↓, *GSK‐3β↓, *ChAT↑, *iNOS↓, *ROS↓, *BBB↑,
5508- Ba,    Neuroprotective effects of baicalin and baicalein on the central nervous system and the underlying mechanisms
- Review, Stroke, NA - Review, Park, NA - Review, AD, NA
*neuroP↑, *antiOx↑, *Inflam↓, *BioAv↝, *BioAv↑, *Half-Life↝, *TLR4↓, *NF-kB↓, *iNOS↓, *COX2/PTGS2↓, *TNF-α↓, *12LOX↓, *NLRP3↓, *ROS↓, *IL1β↓, *IL6↓, *GSK‐3β↓, *NRF2↑, *BBB↑, *SOD↑, *GPx↑, *MDA↓,
5502- Ba,    An overview of pharmacological activities of baicalin and its aglycone baicalein: New insights into molecular mechanisms and signaling pathways
- Review, Var, NA
*AntiCan↑, *antiOx↑, *hepatoP↑, *neuroP↑, *ROS↓, Ca+2↑, ROS↑, BAX↑, Casp3↑, Casp9↑, Cyt‑c↑, MMP↓, Mcl-1↓, PI3K↓, Akt↓, mTOR↓, BAD↓, ERK↓, MEK↓, DR5↑, Fas↑, TumMeta↓, EMT↓, SMAD4↓, TGF-β↓, MMP9↓, MMP2↓, HIF-1↓, 12LOX↓,
4305- Ba,    Study on the Molecular Mechanism of Baicalin Phosphorylation of Tau Protein Content in a Cell Model of Intervention Cognitive Impairment
- in-vitro, NA, SH-SY5Y
*cognitive↑, *p‑Akt↑, *p‑GSK‐3β↑, *p‑tau↓, *neuroP↑, *NF-kB↓, *AMPK↑, *NRF2↑,
4276- BA,    Baicalin Attenuates Oxygen–Glucose Deprivation/Reoxygenation–Induced Injury by Modulating the BDNF-TrkB/PI3K/Akt and MAPK/Erk1/2 Signaling Axes in Neuron–Astrocyte Cocultures
- in-vivo, Stroke, NA
*BDNF↑, *neuroP↑, *TrkB↑, *PI3K↑, *Akt↑, *MAPK↑, *ERK↑, *NO↓, *MDA↓, *SOD↑, *TNF-α↓, *IL1β↓, *IL6?,
2482- Ba,    Modulation of Neuroinflammation in Poststroke Rehabilitation: The Role of 12/15-Lipoxygenase Inhibition and Baicalein
- Review, Stroke, NA
*12LOX↓, *neuroP↑, *eff↑,
2483- Ba,    Baicalein and 12/15-Lipoxygenase in the Ischemic Brain
- in-vivo, Stroke, NA
*12LOX↓, *antiOx↓, *neuroP↑,
2611- Ba,    Baicalein as a potent neuroprotective agent: A review
- Review, Nor, NA - Review, AD, NA - Review, Park, NA
*neuroP↑, *ROS↓, *β-Amyloid↓,
2609- Ba,    Baicalein: unveiling the multifaceted marvel of hepatoprotection and beyond
- Review, NA, NA
*hepatoP↑, *neuroP↑, *Inflam↓,
2623- Ba,    Activation of the Nrf2/HO-1 signaling pathway contributes to the protective effects of baicalein against oxidative stress-induced DNA damage and apoptosis in HEI193 Schwann cells
- in-vitro, Nor, HEI193
*DNAdam↓, *ROS↓, *Bax:Bcl2↓, *p‑NRF2↑, *HO-1↑, *neuroP↑, *MMP↑,
2605- Ba,  BA,    Potential therapeutic effects of baicalin and baicalein
- Review, Var, NA - Review, Stroke, NA - Review, IBD, NA - Review, Arthritis, NA - Review, AD, NA - Review, Park, NA
cardioP↑, Inflam↓, cognitive↑, *hepatoP↑, *ROS?, *SOD↑, *GSH↑, *MMP↑, *GutMicro↑, ChemoSen↑, *TNF-α↓, *IL10↑, *IL6↓, *eff↑, *ROS↓, *COX2/PTGS2↓, *NF-kB↓, *STAT3↓, *PGE2↓, *MPO↓, *IL1β↓, *MMP2↓, *MMP9↓, *β-Amyloid↓, *neuroP↑, *Dose↝, *BioAv↝, *BioAv↝, *BBB↑, *BDNF↑,
2626- Ba,    Molecular targets and therapeutic potential of baicalein: a review
- Review, Var, NA - Review, AD, NA - Review, Stroke, NA
AntiCan↓, *neuroP↑, *cardioP↑, *hepatoP↑, *RenoP↑, TumCCA↑, CDK4↓, cycD1/CCND1↓, cycE/CCNE↑, BAX↑, Bcl-2↓, VEGF↓, Hif1a↓, cMyc↓, NF-kB↓, ROS↑, BNIP3↑, *neuroP↑, *cognitive↑, *NO↓, *iNOS↓, *COX2/PTGS2↓, *PGE2↓, *NRF2↑, *p‑AMPK↑, *Ferroptosis↓, *lipid-P↓, *ALAT↓, *AST↓, *Fas↓, *BAX↓, *Apoptosis↓,
2614- Ba,    Therapeutic potentials of baicalin and its aglycone, baicalein against inflammatory disorders
- Review, NA, NA
*toxicity↓, *antiOx↑, *Inflam↓, *ROS↓, *NF-kB↓, *MCP1/CCL2↓, *hepatoP↑, *neuroP↑,
2689- BBR,    Berberine protects against glutamate-induced oxidative stress and apoptosis in PC12 and N2a cells
- in-vitro, Nor, PC12 - in-vitro, AD, NA - in-vitro, Stroke, NA
*ROS↓, *lipid-P↓, *DNAdam↓, *GSH↑, *SOD↑, *eff↑, *cl‑Casp3↓, *BAX↓, *neuroP↑, *Dose↝, *Ca+2↓,
2678- BBR,    Berberine as a Potential Agent for the Treatment of Colorectal Cancer
- Review, CRC, NA
*Inflam↓, *antiOx↑, *cardioP↑, *neuroP↑, TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, CDC2↓, AMPK↝, mTOR↝, Casp8↑, Casp9↑, Cyt‑c↑, TumCMig↓, TumCI↓, EMT↓, MMPs↓, E-cadherin↓, Telomerase↓, *toxicity↓, GRP78/BiP↓, EGFR↓, CDK4↓, COX2/PTGS2↓, PGE2↓, p‑JAK2↓, p‑STAT3↓, MMP2↓, MMP9↓, GutMicro↑, eff↝, *BioAv↓, BioAv↑,
2673- BBR,    Therapeutic potential and recent delivery systems of berberine: A wonder molecule
- Review, Var, NA
*BioAv↓, *Half-Life↓, *neuroP↑, BBB↑, toxicity↓,
2679- BBR,    Berberine Improves Behavioral and Cognitive Deficits in a Mouse Model of Alzheimer’s Disease via Regulation of β-Amyloid Production and Endoplasmic Reticulum Stress
- in-vivo, AD, NA
*cognitive↑, PERK↓, *eIF2α↓, *neuroP↑, *ER Stress↓, *ROS↓,
3833- BBR,    Traditional Chinese Medicine: Role in Reducing β-Amyloid, Apoptosis, Autophagy, Neuroinflammation, Oxidative Stress, and Mitochondrial Dysfunction of Alzheimer’s Disease
- Review, AD, NA
*cardioP↑, *neuroP↑, *memory↑, *Aβ↓,
3680- BBR,    Network pharmacology reveals that Berberine may function against Alzheimer’s disease via the AKT signaling pathway
- in-vivo, AD, NA
*Akt↑, *neuroP↑, *p‑ERK↑, *Aβ↓, *Inflam↓, *ROS↓, *BioAv↑, *BBB↑, *Half-Life↝, *memory↑, *cognitive↑, *HSP90↑, *APP↓, *mTOR↓, *P70S6K↓, *CD31/PECAM-1↑, *VEGF↑, *N-cadherin↑, *Apoptosis↓,
3681- BBR,    The efficacy and mechanism of berberine in improving aging-related cognitive dysfunction: A study based on network pharmacology
- in-vivo, AD, NA
*memory↑, *cognitive↑, MAPK↑, *Akt↑, *PI3K↑, *TP53↑, *Jun↓, *HSP90↑, *neuroP↑, *Inflam↓, *antiOx↑, *p16↓, *ER Stress↓,
3682- BBR,    Berberine Improves Cognitive Impairment by Simultaneously Impacting Cerebral Blood Flow and β-Amyloid Accumulation in an APP/tau/PS1 Mouse Model of Alzheimer’s Disease
- in-vitro, AD, NA
*cognitive↑, *Aβ↓, *Apoptosis↓, *CD31/PECAM-1↑, *VEGF↑, *N-cadherin↑, *angioG↑, *neuroP↑, *p‑tau↓, *antiOx↑, *AChE↓, *MAOB↓, *lipid-P↓,
3684- BBR,    Neuroprotective effects of berberine in animal models of Alzheimer’s disease: a systematic review of pre-clinical studies
- Review, AD, NA
*Inflam↓, *antiOx↓, *AChE↓, *BChE↓, *MAOA↓, *MAOB↓, *lipid-P↓, *GSH↑, *ROS↓, *APP↓, *BACE/β-secretase↓, *p‑tau↓, *NF-kB↓, *TNF-α↓, *IL1β↓, *MAPK↓, *PI3K↓, *Akt↓, *neuroP↑, *memory↑,
5631- BCA,    Perspectives Regarding the Role of Biochanin A in Humans
- Review, Var, NA - Review, AD, NA
*BioAv↓, *Inflam↓, AntiCan↑, *neuroP↑, chemoPv↑, Dose↝, *SOD↑, *MDA↓, *BAX↓, *HSP70/HSPA5↑, *AntiDiabetic↑, *Insulin↑, *TNF-α↓, *IL1β↓, *IL6↓, *iNOS↓, *COX2/PTGS2↓, *MMP9↓, *ROS↓, *PGE2↓, *BACE/β-secretase↓, *BioAv↑, P-gp/ABCB1⇅,
5633- BCA,    Mechanisms Behind the Pharmacological Application of Biochanin-A: A review
- Review, Var, NA - Review, AD, NA
*AntiDiabetic↑, *neuroP↑, *toxicity↓, *CYP19↓, p‑Akt↓, mTOR↓, TumCCA↑, P21↑, Casp3↑, Bcl-2↑, Apoptosis↑, E-cadherin↓, TumMeta↓, eff↑, GSK‐3β↓, β-catenin/ZEB1↓, RadioS↑, ROS↑, Casp1↑, MMP2↓, MMP9↓, EGFR↓, ChemoSen↑, PI3K↓, MMPs↓, Hif1a↓, VEGF↓, *ROS↓, *Obesity↓, *cardioP↑, *NRF2↑, *NF-kB↓, *Inflam↓, *lipid-P↓, *hepatoP↑, *AST↓, *ALP↓, *Bacteria↓, *neuroP↑, *SOD↑, *GPx↑, *AChE↓, *BACE/β-secretase↓, *memory↑, *BioAv↓,
5634- BCA,    Molecular Mechanisms of Biochanin A in AML Cells: Apoptosis Induction and Pathway-Specific Regulation in U937 and THP-1
- in-vitro, AML, U937 - in-vitro, AML, THP1
Apoptosis↑, Casp7↑, PARP1↑, Bcl-2↓, Myc↓, CHOP/DDIT3↑, P21↑, p62↑, TumCCA↑, TXNIP↑, ROS↑, *antiOx↑, *Inflam↓, *neuroP↑, AntiCan↑, TumCP↓, angioG↓, TumMeta↓, VEGF↓, MMPs↓, tumCV↓, DNAdam↑, CHOP/DDIT3↑, cMyc↓, BioAv↓, Half-Life↓, BioAv↑,
6511- BCP,    Improvement of Oxidative Stress and Mitochondrial Dysfunction by β-Caryophyllene: A Focus on the Nervous System
- Review, AD, NA
*CB2 / CNR2↑, *Bacteria↓, *antiOx↑, *Inflam↓, *NP/CIPN↓, *neuroP↑, AntiCan↑, *ROS↓, *mtDam↓, *GSH↑, *SOD↑, *Catalase↑, *lipid-P↓, *IL1β↓, *IL6↓, *TNF-α↓, *COX2/PTGS2↓, *iNOS↓, *NRF2↑, *HO-1↑, *AChE↓,
6515- BCP,  Xan,    Advancing Brain Health Naturally: β-Caryophyllene and Xanthohumol as Neuroprotective Agents
- Review, AD, NA
*neuroP↑, *BioAv↝, *CB2 / CNR2↑, *Inflam↓, *iNOS↓, *IL1β↓, *IL6↓, *TNF-α↓, *NF-kB↓, *COX1↓, *COX2/PTGS2↓, *PPARα↑, *PPARγ↑, *ROS↓, *tau↓, *NRF2↑, *HO-1↑, *AChE↓, *BChE↓, *BioAv↓,
6512- BCP,    Beta-Caryophyllene Exhibits Anti-Proliferative Effects through Apoptosis Induction and Cell Cycle Modulation in Multiple Myeloma Cells
- in-vitro, MM, NA
CB2 / CNR2↑, BAX↑, Bcl-2↓, Casp3↑, TumCP↓, Apoptosis↑, Akt↓, Wnt↓, β-catenin/ZEB1↓, TumCCA↑, Inflam↓, chemoPv↑, neuroP↑, *BioAv↝, CB2 / CNR2↑, tumCV↓,
6496- BCP,    β-Caryophyllene Induces Apoptosis and Inhibits Angiogenesis in Colorectal Cancer Models
- vitro+vivo, CRC, HCT116 - in-vitro, Nor, HUVECs
angioG↓, VEGF↓, TumVol↓, Apoptosis↑, HSP60/HSPD1↓, HTRA↓, survivin↓, XIAP↓, P21↑, *toxicity↓, *neuroP↑, *ROS↓, *COX2/PTGS2↓, *Inflam↓, *cardioP↑, AntiCan↑, ChemoSen↑, ROS↑, MMP↑, Bax:Bcl2↑, TumCG↓,
6506- BCP,    Multi-Target Protective Effects of β-Caryophyllene (BCP) at the Intersection of Neuroinflammation and Neurodegeneration
- vitro+vivo, Nor, HMC3
*neuroP↑, *NF-kB↓, *SIRT1↑, *PGC-1α↓, *BDNF↓, *TNF-α↓, *IL6↓, *IL10↑, *Inflam↓,
4273- BetA,    Betulinic acid, a natural PDE inhibitor restores hippocampal cAMP/cGMP and BDNF, improve cerebral blood flow and recover memory deficits in permanent BCCAO induced vascular dementia in rats
- in-vivo, NA, NA
*neuroP↑, *BDNF↑, *ROS↓, *Inflam↓, *cognitive↑,
2724- BetA,    Down-regulation of NOX4 by betulinic acid protects against cerebral ischemia-reperfusion in mice
- in-vivo, Nor, NA - in-vivo, Stroke, NA
AntiTum↑, *Inflam↓, *ROS↓, *NOX4↓, *Apoptosis↓, neuroP↑,
2731- BetA,    Betulinic Acid for Glioblastoma Treatment: Reality, Challenges and Perspectives
- Review, GBM, NA - Review, Park, NA - Review, AD, NA
BBB↑, *GSH↑, *Catalase↑, *motorD↑, *neuroP↑, *cognitive↑, *ROS↓, *antiOx↑, *Inflam↓, MMP↓, STAT3↓, NF-kB↓, Sp1/3/4↓, TOP1↓, EMT↓, Hif1a↓, VEGF↓, ChemoSen↑, RadioS↑, BioAv↓,
3986- betaCar,  VitC,    Editorial: Impact of Diet on Learning, Memory and Cognition
- Review, AD, NA
*Risk↓, *neuroP↑,

Showing Research Papers: 51 to 100 of 701
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 701

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

HSP60/HSPD1↓, 1,   HTRA↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

HO-1↑, 1,   NQO1↑, 1,   NRF2↑, 2,   OXPHOS↓, 1,   ROS↓, 2,   ROS↑, 6,   ROS⇅, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC2↓, 1,   MEK↓, 1,   MMP↓, 2,   MMP↑, 1,   XIAP↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,   ACLY↓, 1,   AMPK↑, 1,   AMPK↝, 1,   cMyc↓, 2,   FASN↓, 1,   LDH↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 3,   Akt↑, 1,   p‑Akt↓, 1,   Apoptosis↑, 8,   BAD↓, 1,   BAX↑, 3,   Bax:Bcl2↑, 1,   Bcl-2↓, 4,   Bcl-2↑, 1,   Casp1↑, 1,   Casp3↑, 4,   Casp7↑, 1,   Casp8↑, 1,   Casp9↑, 2,   Cyt‑c↑, 2,   DR5↑, 1,   Fas↑, 1,   JNK↑, 1,   MAPK↑, 1,   Mcl-1↓, 1,   Myc↓, 1,   survivin↓, 1,   Telomerase↓, 1,   TumCD↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Sp1/3/4↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

tumCV↓, 2,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 2,   GRP78/BiP↓, 1,   HSP90↓, 1,   PERK↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

BNIP3↑, 1,   p62↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 1,   PARP1↑, 1,   PCNA↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK4↓, 2,   cycD1/CCND1↓, 2,   cycE/CCNE↓, 1,   cycE/CCNE↑, 1,   P21↑, 3,   TumCCA↑, 7,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CSCs↓, 1,   EMT↓, 5,   ERK↓, 1,   FOXO3↑, 1,   GSK‐3β↓, 1,   GSK‐3β↑, 1,   mTOR↓, 3,   mTOR↝, 1,   NOTCH3↓, 1,   PI3K↓, 3,   PI3K↑, 1,   STAT3↓, 2,   p‑STAT3↓, 1,   TOP1↓, 1,   TumCG↓, 3,   Wnt↓, 1,  

Migration(tgid=13) ⓘ

Ca+2↑, 1,   E-cadherin↓, 2,   MMP2↓, 3,   MMP9↓, 3,   MMPs↓, 3,   N-cadherin↓, 1,   SMAD4↓, 1,   TGF-β↓, 1,   TumCI↓, 1,   TumCMig↓, 2,   TumCP↓, 3,   TumCP↑, 1,   TumMeta↓, 3,   TXNIP↑, 1,   β-catenin/ZEB1↓, 3,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 2,   EGFR↓, 2,   HIF-1↓, 1,   Hif1a↓, 3,   VEGF↓, 5,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 2,   P-gp/ABCB1⇅, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CB2 / CNR2↑, 2,   COX2/PTGS2↓, 1,   IL6↓, 1,   Inflam↓, 2,   p‑JAK2↓, 1,   NF-kB↓, 3,   PGE2↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 2,   BioAv↑, 4,   ChemoSen↑, 6,   ChemoSen⇅, 1,   Dose↝, 1,   eff↑, 4,   eff↝, 1,   Half-Life↓, 1,   RadioS↑, 3,  

Clinical Biomarkers(tgid=22) ⓘ

EGFR↓, 2,   GutMicro↑, 1,   IL6↓, 1,   LDH↓, 1,   Myc↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↓, 1,   AntiCan↑, 7,   AntiTum↑, 2,   cardioP↑, 1,   chemoP↑, 2,   chemoPv↑, 2,   cognitive↑, 1,   neuroP↑, 3,   toxicity↓, 1,   TumVol↓, 1,  
Total Targets: 131

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 2,   antiOx↑, 17,   Catalase↑, 3,   Ferroptosis↓, 1,   GPx↑, 5,   GSH↑, 6,   GSR↑, 1,   GSTs↑, 1,   HO-1↑, 7,   lipid-P↓, 7,   MDA↓, 5,   MPO↓, 1,   NOX4↓, 1,   NRF2↑, 9,   p‑NRF2↑, 1,   Prx↓, 1,   ROS?, 1,   ROS↓, 27,   SOD↑, 10,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↑, 1,   Insulin↑, 1,   MMP↑, 3,   mtDam↓, 2,   PGC-1α↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 3,   ALAT↓, 1,   AMPK↑, 3,   p‑AMPK↑, 1,   LDH↓, 1,   PPARα↑, 1,   PPARγ↑, 2,   p‑PPARγ↓, 1,   SIRT1↑, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,   Akt↑, 4,   p‑Akt↑, 1,   Apoptosis↓, 7,   BAX↓, 3,   Bax:Bcl2↓, 1,   Casp3↓, 1,   cl‑Casp3↓, 1,   Casp9↓, 1,   Fas↓, 1,   Ferroptosis↓, 1,   iNOS↓, 6,   MAPK↓, 1,   MAPK↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

Ach↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

eIF2α↓, 1,   ER Stress↓, 2,   HSP70/HSPA5↑, 1,   HSP90↑, 2,   HSPs↝, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 2,   p16↓, 1,   TP53↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ERK↑, 2,   p‑ERK↑, 1,   GSK‐3β↓, 2,   p‑GSK‐3β↑, 1,   Jun↓, 1,   mTOR↓, 1,   P70S6K↓, 1,   PI3K↓, 1,   PI3K↑, 2,   STAT3↓, 1,  

Migration(tgid=13) ⓘ

APP↓, 2,   Ca+2↓, 1,   CD31/PECAM-1↑, 2,   MMP2↓, 1,   MMP9↓, 2,   N-cadherin↑, 2,   TGF-β↑, 1,   Vim↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↑, 1,   NO↓, 2,   VEGF↑, 2,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 5,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CB2 / CNR2↑, 2,   COX1↓, 1,   COX2/PTGS2↓, 7,   IL10↑, 2,   IL18↓, 1,   IL1β↓, 9,   IL6?, 1,   IL6↓, 10,   IL8↓, 1,   Imm↑, 1,   Inflam↓, 25,   Inflam↑, 1,   MCP1/CCL2↓, 3,   MIP2↓, 1,   NF-kB↓, 11,   PGE2↓, 3,   TLR4↓, 1,   TNF-α↓, 11,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 8,   BChE↓, 3,   BDNF↓, 1,   BDNF↑, 4,   ChAT↑, 2,   MAOA↓, 2,   tau↓, 3,   p‑tau↓, 3,   TrkB↑, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 8,   BACE/β-secretase↓, 4,   MAOB↓, 2,   NLRP3↓, 1,   β-Amyloid↓, 2,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

CYP19↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 6,   BioAv↑, 3,   BioAv↝, 6,   Dose↑, 1,   Dose↝, 2,   eff↑, 3,   Half-Life↓, 1,   Half-Life↝, 4,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   ALP↓, 1,   AST↓, 2,   GutMicro↑, 1,   IL6?, 1,   IL6↓, 10,   LDH↓, 1,   TP53↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,   AntiDiabetic↑, 3,   AntiTum↑, 1,   cardioP↑, 9,   chemoPv↑, 2,   cognitive↑, 13,   hepatoP↑, 7,   memory↑, 9,   motorD↑, 1,   neuroP↑, 49,   NP/CIPN↓, 1,   Obesity↓, 1,   RenoP↑, 1,   Risk↓, 1,   Sleep↑, 1,   Strength↑, 1,   toxicity↓, 4,  

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 3,  
Total Targets: 145

Scientific Paper Hit Count for: neuroP, neuroprotective
23 Resveratrol
21 Thymoquinone
20 Alpha-Lipoic-Acid
19 Quercetin
18 Magnetic Fields
16 Hydrogen Gas
16 Silymarin (Milk Thistle) silibinin
15 Chlorogenic acid
15 Ferulic acid
15 Urolithin
14 Curcumin
13 Rosmarinic acid
11 Baicalein
11 Fisetin
11 Lycopene
10 Ashwagandha(Withaferin A)
10 Mung Bean Sprouts
10 Carvacrol
10 Crocetin
10 EGCG (Epigallocatechin Gallate)
10 Honokiol
9 Berberine
9 Bacopa monnieri
9 Chrysin
8 isoquercitrin
8 Emodin
8 Moringa oleifera
8 Sulforaphane (mainly Broccoli)
7 Allicin (mainly Garlic)
7 Caffeic acid
7 Centella asiatica / Gotu kola → asiaticoside
7 Piperine
7 Huperzine A/Huperzia serrata
7 Taurine
6 Apigenin (mainly Parsley)
6 Selenium NanoParticles
6 Cysteamine
6 Ginkgo biloba-EGb 761
6 Eugenol
6 Folic Acid, Vit B9
6 Ginkgo biloba
6 Ginkgolide B
6 Ginseng
6 Isoliquiritigenin
6 Luteolin
6 Mushroom Lion’s Mane
6 Phenylbutyrate
6 Silicic Acid
5 Astaxanthin
5 Beta-Caryophyllene
5 Vitamin C (Ascorbic Acid)
5 α-Bisabolol / Chamomile oil
5 Capsaicin
5 Hydroxycinnamic-acid
5 Hyperoside
5 Melatonin
5 Piperlongumine
5 Shankhpushpi
5 Shikonin
5 Vitamin E
5 Vitamin B5,Pantothenic Acid
4 Rutin
4 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
4 Boron
4 Boswellia (frankincense)
4 Carnosic acid
4 Carnosine
4 Propolis -bee glue
4 Shilajit/Fulvic Acid
4 Magnetic Field Rotating
4 Pterostilbene
4 Vitamin B12
3 Anthocyanins
3 Artemisinin
3 Biochanin A
3 Betulinic acid
3 Vitamin B6,pyridoxine
3 Caffeic Acid Phenethyl Ester (CAPE)
3 Exercise
3 Celastrol
3 Cichoric acid / Chicoric acid
3 Cinnamon
3 Coenzyme Q10
3 diet Short Term Fasting
3 Fucoidan
3 Ginkgetin
3 HydroxyTyrosol
3 Methylene blue
3 Magnolol
3 nicotinamide adenine dinucleotide
3 Selenite (Sodium)
3 Ursolic acid
2 1,8-Cineole
2 Anethole/trans-Anethole
2 Baicalin
2 beta-carotene(VitA)
2 borneol
2 Thymol-Thymus vulgaris
2 Chlorophyllin
2 Choline
2 Calorie Restriction Mimetics
2 Spermidine
2 Cucurbitacin
2 Metformin
2 Date Fruit Extract
2 D-limonene
2 Dandelion Root
2 Ellagic acid
2 Angelica archangelica / Garden Angelica
2 flavonoids
2 Flickering Light Stimulation
2 Formononetin
2 Gamma-aminobutyric acid
2 Geraniol
2 hydrogen sulfide
2 Oleuropein
2 Isobavachalcone
2 EMF
2 Naringin
2 Nimbolide
2 Phenolic Acids
2 Phosphatidylserine
2 Chemotherapy
2 Vitamin D3
2 Vitamin K2
1 Annona atemoya Leaf Extract
1 Astragalus
1 alpha Linolenic acid
1 Aluminum
1 Fennel Oil/Foeniculum vulgare
1 doxorubicin
1 xanthohumol
1 Butyrate
1 Paclitaxel/Taxol
1 Cynanbungeigenin C (CBC) and D (CBD)
1 chitosan
1 Chyawanprash
1 Selenium
1 Carica papaya leaf extract
1 Aspirin
1 Carvone
1 Cynara scolymus/Globe Artichoke/Artichoke Extract
1 Silver-NanoParticles
1 Dichloroacetate
1 Bortezomib
1 Diclofenac
1 Dihydrocaffeic Acid
1 diet Fermented Foods
1 diet Methionine-Restricted Diet
1 diet FMD Fasting Mimicking Diet
1 Eurycomanone
1 Evodiamine
1 Gallic acid
1 Garcinol
1 Genistein (soy isoflavone)
1 Ginger/6-Shogaol/Gingerol
1 Germacranolide sesquiterpene lactone
1 Helleborus niger extracts – Christmas Rose
1 Inulin Prebiotic
1 Bifidobacterium animalis subsp. lactis GCL2505
1 IP6 (Inositol 1,2,3,4,5,6-hexakisphosphate)
1 Butein
1 Scopoletin
1 isoflavones
1 isoorientin
1 Morin
1 Kaempferol
1 Isovitexin
1 Vitexin
1 MCToil
1 Methylsulfonylmethane
1 Myricetin
1 Neem
1 Olive Oil
1 Protocatechuic acid
1 Polyphenols
1 Psoralidin
1 Sinapic acid
1 Salvia officinalis
1 Aromatherapy
1 Sesame seeds and Oil
1 Anti-oxidants
1 Aflavin-3,3′-digallate
1 Turmerones
1 Vanillic Acid
1 Vitamin A, Retinoic Acid
1 Vitamin B1/Thiamine
1 Vitamin B3,Niacin
1 Zinc
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1105  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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