Fas Cancer Research Results

Fas, Fas Death receptor: Click to Expand ⟱
Source:
Type:
Fas (also known as CD95 or APO-1) and Fas ligand (FasL) are proteins that play a crucial role in the regulation of programmed cell death, also known as apoptosis.

The Fas/FasL system is involved in the elimination of damaged or unwanted cells, including cancer cells.
Fas agonists, which mimic the action of FasL, have been shown to induce apoptosis in cancer cells. FasL inhibitors, which block the interaction between Fas and FasL, have been shown to enhance the effectiveness of chemotherapy and immunotherapy

Fas is often expressed ,and may be associated with better responses to chemotherapy, but its role in promoting cell survival in certain contexts can complicate its prognostic implications.
Scientific Papers found: Click to Expand⟱
7363- HibSad,    Chemopreventive properties of Hibiscus sabdariffa L. on human gastric carcinoma cells through apoptosis induction and JNK/p38 MAPK signaling activation
- in-vitro, GC, NA
Apoptosis↑, selectivity↑, p‑p38↑, JNK↑, cJun↑, Cyt‑c↑, Fas↑, FasL↑,
7357- HibSad,    Hibiscus Anthocyanins Extracts Induce Apoptosis by Activating AMP-Activated Protein Kinase in Human Colorectal Cancer Cells
- in-vitro, CRC, LoVo
Apoptosis↑, AMPK↑, Fas↑, Casp8↑, Cyt‑c↑, cl‑Casp3↑, Dose↝, mtDam↑, MMP↓, Akt↓,
7353- HibSad,    Hibiscus sabdariffa Leaf Polyphenolic Extract Induces Human Melanoma Cell Death, Apoptosis, and Autophagy
- in-vitro, Melanoma, A375
cl‑Casp↑, Bcl-2↓, Fas↑, FasL↑, ATG5↑, Beclin-1/ATG6↑, LC3B-II↑, TumAuto↑,
7350- HibSad,    Hibiscus polyphenol-rich extract induces apoptosis in human gastric carcinoma cells via p53 phosphorylation and p38 MAPK/FasL cascade pathway
- in-vitro, GC, AGS
TumCD↑, DNAdam↑, P53↑, Bcl-2↓, Mcl-1↓, Cyt‑c↑, FasL↑, Fas↑, p38↑, BAX↑, Dose↝, TumCCA↑,
4640- HT,    The anti-cancer potential of hydroxytyrosol
- Review, Var, NA
selectivity↑, MMP↓, Cyt‑c↑, Casp9↑, Casp3↑, Bcl-2↓, BAX↑, MPT↑, Fas↑, PI3K↓, Akt↓, mTOR↓, Mcl-1↓, survivin↓, STAT3↓, EMT↓, TumCI↓, angioG↓, E-cadherin↑, N-cadherin↓, Snail↓, Twist↓, MMPs↓, MMP2↓, MMP9↓, VEGF↓, VEGFR2/KDR/Flk1↓, Hif1a↓, CSCs↓, CD44↓, Wnt↓, β-catenin/ZEB1↓,
7567- HYP,    Hyperoside: A review on its sources, biological activities, and molecular mechanisms
- Review, Var, NA
*AntiCan↑, *Bacteria↓, *AntiViral↑, *antiD↓, *RenoP↑, *hepatoP↑, *eff↑, *Sepsis↓, *AntiArt↑, *Stroke↓, TumCMig↓, TumCI↓, MTA1↓, TIMP2↓, MMP2↓, MMP↓, Cyt‑c↑, Akt↓, mTOR↓, P70S6K↓, TumAuto↑, PD-L1↓, TNF-α↓, IL1β↓, IL6↓, IL8↓, Bcl-2↓, Bcl-xL↓, BAX↑, BAD↑, Bak↑, VEGF↓, Casp3↑, Casp8↑, P53↑, GSH↓, SOD↓, Catalase↓, TAC↓, XIAP↓, ROS↓, NF-kB↓, TLR4↓, P-gp/ABCB1↓, LRP1↓, Fas↑, p27/CDKN1B↑, *cardioP↑, *AntiThr↑, *PAI-1/SERPINE1↓, *BUN↓, *ALAT↓, *AST↓, *neuroP?,
7607- I3C,    Indole-3-carbinol induces G1 cell cycle arrest and apoptosis through aryl hydrocarbon receptor in THP-1 monocytic cell line
- in-vitro, AML, THP1
AhR↑, TumCP↓, selectivity↑, Bcl-2↓, Fas↑, P21↑, p27/CDKN1B↑, P53↓, CDK2↓,
7591- I3C,    Indole-3-carbinol (I3C)-induced apoptosis in nasopharyngeal cancer cells through Fas/FasL and MAPK pathway
- in-vitro, NPC, CNE2
Apoptosis↑, MMP↓, XIAP↓, IAP1↓, survivin↓, Diablo↑, Cyt‑c↑, HTRA2/Omi/PARK13↑, mtDam↑, Fas↑, FasL↑,
7855- isoO,    Isoorientin induces apoptosis and autophagy simultaneously by reactive oxygen species (ROS)-related p53, PI3K/Akt, JNK, and p38 signaling pathways in HepG2 cancer cells
- in-vitro, Liver, HepG2 - in-vitro, Nor, HL7702
TumAuto↑, Beclin-1/ATG6↑, LC3II↑, eff↓, ROS↑, Fas↑, P53↓, PI3K↓, Akt↓, NF-kB↓, Cyt‑c↑, Casp3↑, cl‑PARP↑,
5115- JG,    Natural Products to Fight Cancer: A Focus on Juglans regia
- Review, Var, NA
Casp3↑, Casp9↑, MMP↓, AR↓, PSA↓, E-cadherin↑, N-cadherin↓, Vim↓, Akt↓, GSK‐3β↓, EMT↑, TumCI↓, MMP9↓, VEGF↓, MMP2↓, TumCCA↑, ROS↑, Apoptosis↑, GSH↓, Catalase↓, SOD↓, GPx↓, DNAdam↑, γH2AX↑, Synergy↑, BAX↑, Fas↑, Pin1↓,
8055- KAE,    Molecular Mechanisms of the Anticancer Activity of the Flavonoid Kaempferol: A Comprehensive Review
- Review, Var, NA
antiNeop↑, *toxicity↓, TumCCA↑, ROS↑, ER Stress↑, TumAuto↑, Pyro↑, Ferroptosis↑, angioG↓, Imm↝, Synergy↑, ChemoSen↑, MPT↑, MMP↓, mtDam↑, Cyt‑c↑, Bax:Bcl2↑, Fas↑, DR4↑, DR5↑, JNK↑, ERK↑, CHOP/DDIT3↑, ER Stress↑, UPR↑, Ca+2↑, PI3K↓, Akt↓, mTOR↓, AMPK↑, *Ferroptosis↓, *antiOx↑, *NRF2↑, *GPx4↑, *ROS↓, *MDA↓, *i-Iron↓, *xCT/SLC7A11↑, VEGF↓, Wnt↓, β-catenin/ZEB1↓, EMT↓, STAT3↓, M2 MC↓, MCP1/CCL2↓, MMP9↓, MMP2↓, TIMP2↓, ChemoSen↑, PKM2↑, Glycolysis↓, CSCs↓, SOX4↓, OCT4↓, CD44↓, Nanog↓, MDR1↓, *GutMicro↑,
8155- lamb,    Ethanol extract of Pinus koraiensis leaves containing lambertianic acid exerts anti-obesity and hypolipidemic effects by activating adenosine monophosphate-activated protein kinase (AMPK)
- vitro+vivo, Nor, 3T3
*p‑AMPK↑, *PPARγ↓, *CEBPA↓, *adiP↓, *Fas↓, *SREBP1/SREBF1↓, *HMGCR↓, *lipidLev↓, *TG/TAG↓, *Weight↓, *LDL↓, *Obesity↓,
8244- LCA,    Licochalcone A from licorice root, an inhibitor of human hepatoma cell growth via induction of cell apoptosis and cell cycle arrest
- in-vitro, Liver, HepG2
TumCP↓, ROS↑, TumCCA↑, Apoptosis↑, survivin↓, CycB/CCNB1↓, CDK1↓, WEE1↑, P21↑, cycD1/CCND1↑, JNK↑, TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, DR5↑, Casp3↑, Casp8↑, Casp10↑, Fas↑, BAD↑, BAX↑, PUMA↑, PKCδ↓, P70S6K↓, Akt↓,
8235- LCA,    Anticancer effects of licochalcones: A review of the mechanisms
- Review, Var, NA
mt-Apoptosis↑, TumAuto↑, TumCMig↓, LC3‑Ⅱ/LC3‑Ⅰ↑, ATG5↑, ATG7↑, p62↑, CHOP/DDIT3↑, ER Stress↑, UPR↑, ATG3↑, Beclin-1/ATG6↑, ATG16L1↑, PERK↑, ATF4↑, ATP↓, Hif1a↓, GLUT1↓, PDK1 / PDPK1↓, Bcl-xL↓, Bcl-2↓, BAD↑, BAX↑, Casp3↑, survivin↓, EGFR↓, ERK↓, Akt↓, mtDam↑, MMP↓, Cyt‑c↑, Casp↑, MDM2↓, CycB/CCNB1↓, CDC2↓, CDC25↓, TumCCA↑, TumCP↓, Wnt↓, β-catenin/ZEB1↓, Sp1/3/4↓, MMP-10↓, MMP3↓, TumCI↓, Imm↑, PD-L1↓, ROS↑, 4E-BP1↓, eIF2α↓, PI3K↓, mTOR↓, p‑cMET↑, Ca+2↑, RUBCN↓, ATG13↑, TSC1↑, TSC2↑, PRAS40↑, PP2A↑, ULK1/ATG1↑, THEM4/CTMP↑, DR5↑, Fas↑, TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, PKCδ↓, P70S6K↓, VEGF↓, angioG↓, HK2↓, Glycolysis↓, TrxR1↓, APAF1↑, cl‑PARP↑, Bax:Bcl2↑, ABCG2↓, BioEnh↑,
8341- LDN,    Low-Dose Naltrexone as an Adjuvant in Combined Anticancer Therapy
- Review, Var, NA
OGFr↑, TumCP↓, TumCCA↑, Apoptosis↑, toxicity↝, Half-Life↝, *FasL↓, *Fas↓, BAX↑, Casp9↑, Casp3↑, Bcl-2↓, survivin↓, PI3K↓, PDK1 / PDPK1↓, mTOR↓, ChemoSen↑, chemoP↑, Synergy↑, QoL∅,
2921- LT,    Luteolin as a potential hepatoprotective drug: Molecular mechanisms and treatment strategies
- Review, Nor, NA
*hepatoP↑, *AMPK↑, *SIRT1↑, *ROS↓, STAT3↓, TNF-α↓, NF-kB↓, *IL2↓, *IFN-γ↓, *GSH↑, *SREBP1/SREBF1↓, *ZO-1↑, *TLR4↓, BAX↑, Bcl-2↓, XIAP↓, Fas↑, Casp8↑, Beclin-1/ATG6↑, *TXNIP↓, *Casp1↓, *IL1β↓, *IL18↓, *NLRP3↓, *MDA↓, *SOD↑, *NRF2↑, *ER Stress↓, *ALAT↓, *AST↓, *iNOS↓, *IL6↓, *HO-1↑, *NQO1↑, *PPARα↑, *ATF4↓, *CHOP/DDIT3↓, *Inflam↓, *antiOx↑, *GutMicro↑,
2906- LT,    Luteolin, a flavonoid with potentials for cancer prevention and therapy
- Review, Var, NA
*Inflam↓, AntiCan↑, antiOx⇅, Apoptosis↑, TumCP↓, TumMeta↓, angioG↓, PI3K↓, Akt↓, NF-kB↓, XIAP↓, P53↑, *ROS↓, *GSTA1↑, *GSR↑, *SOD↑, *Catalase↑, *other↓, ROS↑, Dose↝, chemoP↑, NF-kB↓, JNK↑, p27/CDKN1B↑, P21↑, DR5↑, Casp↑, Fas↑, BAX↑, MAPK↓, CDK2↓, IGF-1↓, PDGF↓, EGFR↓, PKCδ↓, TOP1↓, TOP2↓, Bcl-xL↓, FASN↓, VEGF↓, VEGFR2/KDR/Flk1↓, MMP9↓, Hif1a↓, FAK↓, MMP1↓, Twist↓, ERK↓, P450↓, CYP1A1↓, CYP1A2↓, TumCCA↑,
2912- LT,    Luteolin: a flavonoid with a multifaceted anticancer potential
- Review, Var, NA
ROS↑, TumCCA↑, TumCP↓, angioG↓, ER Stress↑, mtDam↑, PERK↑, ATF4↑, eIF2α↑, cl‑Casp12↑, EMT↓, E-cadherin↑, N-cadherin↓, Vim↓, *neuroP↑, NF-kB↓, PI3K↓, Akt↑, XIAP↓, MMP↓, Ca+2↑, BAX↑, Casp3↑, Casp9↑, Bcl-2↓, Cyt‑c↑, IronCh↑, SOD↓, *ROS↓, *LDHA↑, *SOD↑, *GSH↑, *BioAv↓, Telomerase↓, cMyc↓, hTERT/TERT↓, DR5↑, Fas↑, FADD↑, BAD↑, BOK↑, BID↑, NAIP↓, Mcl-1↓, CDK2↓, CDK4↓, MAPK↓, AKT1↓, Akt2↓, *Beclin-1/ATG6↓, Hif1a↓, LC3II↑, Beclin-1/ATG6↑,
2919- LT,    Luteolin as a potential therapeutic candidate for lung cancer: Emerging preclinical evidence
- Review, Var, NA
RadioS↑, ChemoSen↑, chemoP↑, *lipid-P↓, *Catalase↑, *SOD↑, *GPx↑, *GSTs↑, *GSH↑, *TNF-α↓, *IL1β↓, *Casp3↓, *IL10↑, NRF2↓, HO-1↓, NQO1↓, GSH↓, MET↓, p‑MET↓, p‑Akt↓, HGF/c-Met↓, NF-kB↓, Bcl-2↓, SOD2↓, Casp8↑, Casp3↑, PARP↑, MAPK↓, NLRP3↓, ASC↓, Casp1↓, IL6↓, IKKα↓, p‑p65↓, p‑p38↑, MMP2↓, ICAM-1↓, EGFR↑, p‑PI3K↓, E-cadherin↓, ZO-1↑, N-cadherin↓, CLDN1↓, β-catenin/ZEB1↓, Snail↓, Vim↑, ITGB1↓, FAK↓, p‑Src↓, Rac1↓, Cdc42↓, Rho↓, PCNA↓, Tyro3↓, AXL↓, CEA↓, NSE↓, SOD↓, Catalase↓, GPx↓, GSR↓, GSTs↓, GSH↓, VitE↓, VitC↓, CYP1A1↓, cFos↑, AR↓, AIF↑, p‑STAT6↓, p‑MDM2↓, NOTCH1↓, VEGF↓, H3↓, H4↓, HDAC↓, SIRT1↓, ROS↑, DR5↑, Cyt‑c↑, p‑JNK↑, PTEN↓, mTOR↓, CD34↓, FasL↑, Fas↑, XIAP↓, p‑eIF2α↑, CHOP/DDIT3↑, LC3II↑, PD-1↓, STAT3↓, IL2↑, EMT↓, cachexia↓, BioAv↑, *Half-Life↝, *eff↑,
8511- MAG,    Suppression of PKCδ/NF-κB Signaling and Apoptosis Induction through Extrinsic/Intrinsic Pathways Are Associated Magnolol-Inhibited Tumor Progression in Colorectal Cancer In Vitro and In Vivo
- vitro+vivo, CRC, HT-29 - in-vitro, Colon, CT26
p‑PKCδ↓, p‑NF-kB↓, TumCI↓, Fas↓, FasL↓, TumCG?, toxicity↓, cl‑Casp8↑, MMP↓, Casp9↑, ChemoSen↑,
8575- Matr,    Matrine induces apoptosis in gastric carcinoma cells via alteration of Fas/FasL and activation of caspase-3
- in-vitro, GC, SGC-7901
TumPF↓, Apoptosis↑, Fas↑, FasL↑, Casp3↑,
4353- MF,  Chemo,    Pulsed Electromagnetic Field Enhances Doxorubicin-induced Reduction in the Viability of MCF-7 Breast Cancer Cells
- in-vitro, BC, MCF7
TumCCA↑, Apoptosis↑, ChemoSen↑, TumCCA↑, Casp↝, p‑CDK2↓, cycE/CCNE↓, Fas↑, BAX↑, survivin↓, Mcl-1↓, cl‑PARP↑, cl‑Casp7↑, cl‑Casp8↑, cl‑Casp9↑,
8862- MOR,    The flavonoid morin from Moraceae induces apoptosis by modulation of Bcl-2 family members and Fas receptor in HCT 116 cells
- in-vitro, CRC, HCT116
Fas↑, Casp8↑, Casp9↑, Casp3↑, BID↑, MMP↓, BAX↑, Cyt‑c↑, ROS↑, Bcl-2↓, IAP1↓, Apoptosis↑, Akt↓,
8952- mushLions,    Induction Apoptosis of Erinacine A in Human Colorectal Cancer Cells Involving the Expression of TNFR, Fas, and Fas Ligand via the JNK/p300/p50 Signaling Pathway With Histone Acetylation
- vitro+vivo, CRC, DLD1
TNFR 1↑, Fas↑, FasL↑, Casp↑, Bcl-2↓, Bcl-xL↓, tumCV↓, selectivity↑, MMP2↓, MMP9↓, Apoptosis↑, Dose↝,
9058- PatchO,    Patchouli oil isolated from the leaves of Pogostemon cablin ameliorates ethanol-induced acute liver injury in rats via inhibition of oxidative stress and lipid accumulation
- in-vivo, LiverDam, NA
*hepatoP↑, *ALAT↓, *AST↓, *ALP↓, *LDH↓, *ROS↓, *TNF-α↓, *FFA/NEFA↓, *TG/TAG↓, *GSH↑, *GSR↑, *SOD↑, *GSH/GSSG↑, *AMPK↑, *PPARα↑, *CPT1A↑, *NF-kB↓, *SREBP1/SREBF1↓, *Fas↓, *SCD1↓, *lipid-P↓,
9049- PatchO,    Inhibitory effects of patchouli alcohol on hepatocellular carcinoma growth through accumulation of oxidative stress and inactivation of androgen receptor signaling
- vitro+vivo, HCC, HepG2 - in-vivo, Liver, HUH7
ROS?, MMP↓, DNAdam↑, TumCCA↑, Apoptosis↑, P53↑, P21↑, Fas↑, FasL↑, Casp8↑, BAX↑, Casp9↑, ChemoSen↑, AR↓, TumCP↓, selectivity↑, eff↓, Snail↓, Twist↓, ICAM-1↓, VCAM-1↓, MMP9↓, EMT↓, toxicity↓, chemoP↑,
1663- PBG,    Propolis and Their Active Constituents for Chronic Diseases
- Review, Var, NA
NF-kB↓, Casp↓, Fas↓, DNAdam↑, Casp3↑, P53↝, MMP↝, ROS↑, mtDam↑, Dose?, angioG↓, TumCP↓, TumCMig↓, BAX↑, selectivity↑, MMP↓, LDH↓, IL6↓, IL1β↓, TNF-α↓,
4922- PEITC,    Phenethyl Isothiocyanate: A comprehensive review of anti-cancer mechanisms
- Review, Var, NA
Risk↓, AntiCan↑, TumCP↓, TumMeta↓, ChemoSen↑, *BioAv↑, *other↝, *Dose↝, Dose↓, *BioAv↑, *Dose↝, *Half-Life↝, *toxicity↝, GSH↓, ROS↑, CYP1A1↑, CYP1A2↑, P450↓, CYP2E1↑, CYP3A4↓, CYP2A3/CYP2A6↓, *ROS↓, *GPx1↑, *SOD1↑, *SOD2↑, Akt↓, EGFR↓, HER2/EBBR2↓, P53↑, Telomerase↓, selectivity↑, MMP↓, Cyt‑c↑, Apoptosis↑, DR4↑, Fas↑, XIAP↓, survivin↓, TumAuto↑, Hif1a↓, angioG↓, MMPs↓, ERK↓, NF-kB↓, EMT↓, TumCI↓, TumCMig↓, Glycolysis↓, ATP↓, selectivity↑, *antiOx↑, Dose↝, other↝, OCR↓, GSH↓, ITGB1↓, ITGB6↓, ChemoSen↑,
5217- PG,    Role of redox signaling regulation in propyl gallate-induced apoptosis of human leukemia cells
- in-vitro, AML, THP1 - in-vitro, AML, Jurkat - in-vitro, AML, HL-60
tumCV↓, Casp3↑, Casp8↑, Casp9↑, P53↑, BAX↑, Fas↑, FasL↑, MAPK↑, NRF2↓, GSH↓,
9011- Phyco,    Phycocyanin: A Potential Drug for Cancer Treatment
- Review, Var, NA
*antiOx↑, *Inflam↓, *AntiCan↑, *Imm↑, *RenoP↑, *hepatoP↑, Synergy↑, EMT↓, TumCCA↑, P21↑, cycE/CCNE↓, CDK2↓, Cyt‑c↑, Casp↑, cl‑PARP1↑, Bax:Bcl2↑, MMP↓, ROS↑, CD59↑, Fas?, IL1β↓, IL2↓, IFN-γ↓, TNF-α↓, JAK3↓, STAT3↓, IL4↑, COX2/PTGS2↓, PGE2↓, MMP9↓, MMP2↓, MMP9↓, TIMP2↓, Vim↓, COL1↓, E-cadherin↑, MDR1↓, AP-1↓, ChemoSen↑, chemoP↑, RadioS↑, TumAuto↑,
48- QC,    Quercetin Potentiates Apoptosis by Inhibiting Nuclear Factor-kappaB Signaling in H460 Lung Cancer Cells
- in-vitro, NSCLC, H460
TRAILR↑, Casp10↑, DFF45↑, TNFR 1↑, Fas↑, NF-kB↓, IKKα↓,
76- QC,    Multifaceted preventive effects of single agent quercetin on a human prostate adenocarcinoma cell line (PC-3): implications for nutritional transcriptomics and multi-target therapy
- in-vitro, Pca, PC3
aSmase↝, Diablo↑, Fas↓, Hsc70↓, Hif1a↓, Mcl-1↓, HSP90↓, FLT4↓, EphB4↓, DNA-PK↓, PARP1↓, ATM↓, XIAP↝, PLC↓, GnT-V↝, heparanase↝, NM23↑, CSR1↑, SPP1↓, DNMT1↓, HDAC4↓, CXCR4↓, β-catenin/ZEB1↓, FBXW7↝, AMACR↓, cycD1/CCND1↓, IGF-1R↓, IMPDH1↓, IMPDH2↓, HEC1↓, NHE1↓, NOS2↓,
923- QC,    Quercetin as an innovative therapeutic tool for cancer chemoprevention: Molecular mechanisms and implications in human health
- Review, Var, NA
ROS↑, GSH↓, Ca+2↝, MMP↓, Casp3↑, Casp8↑, Casp9↑, other↓, *ROS↓, *NRF2↑, HO-1↑, TumCCA↑, Inflam↓, STAT3↓, DR5↑, P450↓, MMPs↓, IFN-γ↓, IL6↓, COX2/PTGS2↓, IL8↓, iNOS↓, TNF-α↓, cl‑PARP↑, Apoptosis↑, P53↑, Sp1/3/4↓, survivin↓, TRAILR↑, Casp10↑, DFF45↑, TNFR 1↑, Fas↑, NF-kB↓, IKKα↓, cycD1/CCND1↓, Bcl-2↓, BAX↑, PI3K↓, Akt↓, E-cadherin↓, Vim↓, β-catenin/ZEB1↓, cMyc↓, EMT↓, MMP2↓, NOTCH1↓, MMP7↓, angioG↓, TSP-1↑, CSCs↓, XIAP↓, Snail↓, Slug↓, LEF1↓, P-gp/ABCB1↓, EGFR↓, GSK‐3β↓, mTOR↓, RAGE↓, HSP27↓, VEGF↓, TGF-β↓, COL1↓, COL3A1↓,
4486- Se,  Chit,    Selenium-Modified Chitosan Induces HepG2 Cell Apoptosis and Differential Protein Analysis
- in-vitro, Liver, HepG2
Apoptosis↑, TumCCA↑, MMP↓, Bcl-2↓, BAX↑, cl‑Casp9↑, cl‑Casp3↑, Risk↓, *BioAv↑, *toxicity↑, TumCG↓, AntiTum↑, ROS↑, Cyt‑c↑, Fas↑, FasL↑, FADD↑,
1726- SFN,    Sulforaphane: A Broccoli Bioactive Phytocompound with Cancer Preventive Potential
- Review, Var, NA
Dose↝, eff↝, IL1β↓, IL6↓, IL12↓, TNF-α↓, COX2/PTGS2↓, CXCR4↓, MPO↓, HSP70/HSPA5↓, HSP90↓, VCAM-1↓, IKKα↓, NF-kB↓, HO-1↑, Casp3↑, Casp7↑, Casp8↑, Casp9↑, cl‑PARP↑, Cyt‑c↑, Diablo↑, CHOP/DDIT3↑, survivin↓, XIAP↓, p38↑, Fas↑, PUMA↑, VEGF↓, Hif1a↓, Twist↓, Zeb1↓, Vim↓, MMP2↓, MMP9↓, E-cadherin↑, N-cadherin↓, Snail↓, CD44↓, cycD1/CCND1↓, cycA1/CCNA1↓, CycB/CCNB1↓, cycE/CCNE↓, CDK4↓, CDK6↓, p50↓, P53↑, P21↑, GSH↑, SOD↑, GSTs↑, mTOR↓, Akt↓, PI3K↓, β-catenin/ZEB1↓, IGF-1↓, cMyc↓, CSCs↓,
3289- SIL,    Silymarin: a promising modulator of apoptosis and survival signaling in cancer
- Review, Var, NA
*BioAv↝, *BioAv↓, Fas↑, FasL↑, FADD↑, pro‑Casp8↑, Apoptosis↑, DR5↑, Bcl-2↑, BAX↑, Casp3↑, PI3K↓, FOXM1↓, p‑mTOR↓, p‑P70S6K↓, Hif1a↓, Akt↑, angioG↓, STAT3↓, NF-kB↓, lipid-P↓, Synergy↑, CDK1↓, survivin↓, CycB/CCNB1↓, Mcl-1↓, Casp9↑, AP-1↓, BioAv↑,
3330- SIL,    Mechanistic Insights into the Pharmacological Significance of Silymarin
- Review, Var, NA
*neuroP↑, *hepatoP↑, *cardioP↑, *antiOx↓, *NLRP3↓, *NAD↑, ROS↓, NLRP3↓, TumCMig↓, *COX2/PTGS2↓, *iNOS↓, *MPO↓, *AChE↓, *LDH↓, *Telomerase↓, *Fas↓,
3427- TQ,    Chemopreventive and Anticancer Effects of Thymoquinone: Cellular and Molecular Targets
- in-vitro, Var, NA
ROS⇅, Fas↑, DR5↑, TRAIL↑, Casp3↑, Casp8↑, Casp9↑, P53↑, mTOR↓, Bcl-2↓, BID↓, CXCR4↓, JNK↑, p38↑, MAPK↑, LC3II↑, ATG7↑, Beclin-1/ATG6↑, AMPK↑, PPARγ↑, eIF2α↓, P70S6K↓, VEGF↓, ERK↓, NF-kB↓, XIAP↓, survivin↓, p65↓, DLC1↑, FOXO↑, TET2↑, CYP1B1↑, UHRF1↓, DNMT1↓, HDAC1↓, IL2↑, IL1↓, IL6↓, IL10↓, IL12↓, TNF-α↓, iNOS↓, COX2/PTGS2↓, 5LO↓, AP-1↓, PI3K↓, Akt↓, cMET↓, VEGFR2/KDR/Flk1↓, CXCL1↓, ITGA5↓, Wnt↓, β-catenin/ZEB1↓, GSK‐3β↓, Myc↓, cycD1/CCND1↓, N-cadherin↓, Snail↓, Slug↓, Vim↓, Twist↓, Zeb1↓, MMP2↓, MMP7↓, MMP9↓, JAK2↓, STAT3↓, NOTCH↓, cycA1/CCNA1↓, CDK2↓, CDK4↓, CDK6↓, CDC2↓, CDC25↓, Mcl-1↓, E2Fs↓, p16↑, p27/CDKN1B↑, P21↑, ChemoSen↑,
1824- VitK2,    Vitamin K and its analogs: Potential avenues for prostate cancer management
- Review, Pca, NA
AntiCan↑, toxicity∅, Risk↓, Apoptosis↑, ROS↑, TumCCA↑, Synergy↑, DNAdam↑, MMP↓, Cyt‑c↑, pro‑Casp3↑, FasL↑, Fas↑, TumAuto↑, ChemoSen↑, RadioS↑,
1751- WBV,    Yoda1 Enhanced Low-Magnitude High-Frequency Vibration on Osteocytes in Regulation of MDA-MB-231 Breast Cancer Cell Migration
- in-vitro, BC, MDA-MB-231 - in-vitro, AML, RAW264.7
BMD↑, YAP/TEAD↑, TumCG↓, Strength↑, TumCI↓, Fas↑, Ca+2↑,

Showing Research Papers: 51 to 90 of 90
Prev Page 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 90

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx⇅, 1,   Catalase↓, 4,   GPx↓, 3,   GPx4↓, 1,   GSH↓, 12,   GSH↑, 1,   GSR↓, 1,   GSTs↓, 1,   GSTs↑, 1,   GSTs↝, 1,   H2O2↑, 1,   HO-1↓, 1,   HO-1↑, 2,   lipid-P↓, 1,   lipid-P↑, 1,   MPO↓, 1,   NQO1↓, 1,   NRF2↓, 3,   NRF2↑, 2,   NRF2⇅, 1,   ROS?, 1,   ROS↓, 2,   ROS↑, 39,   ROS⇅, 1,   mt-ROS↑, 1,   SOD↓, 5,   SOD↑, 1,   SOD2↓, 1,   TAC↓, 1,   TrxR1↓, 2,   VitC↓, 1,   VitE↓, 1,   xCT/SLC7A11↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC2↓, 4,   CDC25↓, 7,   ETC↓, 2,   ETC↝, 1,   HTRA2/Omi/PARK13↑, 1,   mtDam↑, 7,   OCR↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 2,   5LO↓, 1,   ACC↑, 1,   ACC-α↓, 1,   Acetyl-CoA↓, 1,   ACLY↓, 2,   ALAT↓, 1,   AMACR↓, 1,   AMPK↑, 9,   ATGL/PNPLA2↓, 1,   ATP↓, 4,   FASN↓, 1,   FFA/NEFA↓, 1,   GlucoseCon↓, 1,   Glycolysis↓, 6,   GSK‐3β↓, 4,   GSK‐3β↑, 3,   H2S↑, 1,   HK2↓, 1,   HSL/LIPE↓, 1,   p‑HSL/LIPE↑, 1,   lactateProd↓, 2,   PCK1↓, 1,   PDK1 / PDPK1↓, 4,   PKM2↓, 1,   PKM2↑, 1,   SIRT1↓, 3,   SREBP1/SREBF1↓, 1,   TCA↓, 1,  

Cell Death(tgid=5) ⓘ

AIF↑, 2,   APAF1↑, 4,   Apoptosis↓, 1,   Apoptosis↑, 42,   mt-Apoptosis↑, 1,   ASC↓, 1,   aSmase↝, 1,   BAD↓, 2,   BAD↑, 8,   Bak↓, 1,   Bak↑, 4,   BAX↓, 1,   BAX↑, 43,   Bax:Bcl2↑, 7,   Bcl-2↓, 40,   Bcl-2↑, 1,   Bcl-xL↓, 7,   Bcl-xL↑, 1,   BID↓, 1,   BID↑, 5,   cl‑BID↑, 1,   BIM↑, 1,   BNIP3↑, 1,   BNIP3↝, 1,   BOK↑, 2,   Casp↓, 1,   Casp↑, 9,   Casp↝, 1,   cl‑Casp↑, 1,   Casp1↓, 1,   Casp1↑, 1,   Casp10↑, 3,   Casp12↑, 2,   cl‑Casp12↑, 1,   Casp2↑, 2,   Casp3↓, 1,   Casp3↑, 43,   cl‑Casp3↑, 3,   proCasp3↓, 1,   pro‑Casp3↑, 1,   Casp7↑, 7,   cl‑Casp7↑, 1,   Casp8↓, 1,   Casp8↑, 30,   cl‑Casp8↑, 3,   proCasp8↓, 1,   proCasp8↑, 1,   pro‑Casp8↑, 1,   Casp9↑, 33,   cl‑Casp9↑, 2,   proCasp9↓, 1,   CSR1↑, 1,   Cyt‑c↑, 39,   Diablo↑, 5,   DR5↑, 16,   FADD↑, 10,   Fas?, 1,   Fas↓, 7,   Fas↑, 73,   FasL↓, 2,   FasL↑, 23,   Ferroptosis↑, 1,   IAP1↓, 3,   IAP2/BIRC3↓, 1,   iNOS↓, 2,   Mcl-1↓, 12,   cl‑Mcl-1↑, 1,   MDM2↓, 4,   p‑MDM2↓, 1,   MOMP↑, 1,   NAIP↓, 2,   necrosis↑, 1,   NOXA↑, 1,   p38↑, 8,   p‑p38↓, 1,   p‑p38↑, 2,   PUMA↑, 4,   Pyro↑, 1,   survivin↓, 15,   TNFR 1↑, 3,   TRAIL↑, 5,   TRAILR↑, 3,   TumCD↑, 3,   TUNEL↑, 1,   XIAP↓, 14,   XIAP↝, 1,   YAP/TEAD↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 25,   Akt↑, 2,   p‑Akt↓, 4,   AKT1↓, 1,   Akt2↓, 1,   CK2↓, 1,   cMET↓, 1,   p‑cMET↑, 1,   EGFR↓, 9,   EGFR↑, 2,   EphB4↓, 1,   ERK↓, 10,   ERK↑, 2,   p‑ERK↓, 1,   FGFR1↓, 2,   FGFR2↓, 1,   FLT4↓, 1,   HER2/EBBR2↓, 3,   HGF/c-Met↓, 1,   IGF-1R↓, 1,   IGF-1R↑, 1,   IKKα↓, 4,   p‑IKKα↓, 1,   IR↓, 1,   JAK↓, 1,   JAK1↓, 1,   JAK2↓, 1,   JAK3↓, 1,   JNK↓, 2,   JNK↑, 12,   p‑JNK↑, 1,   MAPK↓, 10,   MAPK↑, 5,   MEK↓, 2,   p‑MEK↓, 1,   mTOR↓, 16,   p‑mTOR↓, 2,   mTORC2↓, 1,   P70S6K↓, 4,   p‑P70S6K↓, 1,   PAK↓, 1,   PDE3B↓, 1,   PI3K↓, 19,   PI3K↑, 1,   p‑PI3K↓, 1,   PI3k/Akt/mTOR↝, 1,   p‑PKA↓, 1,   PKCδ↓, 3,   p‑PKCδ↓, 1,   PP2A↑, 1,   PRAS40↑, 1,   PTEN↓, 1,   PTEN↑, 1,   RAS↓, 2,   Rictor↓, 1,   Sp1/3/4↓, 2,   p‑Src↓, 1,   STAT3↓, 15,   p‑STAT3↓, 2,   STAT4↓, 1,   STAT5↓, 1,   p‑STAT6↓, 1,   THEM4/CTMP↑, 1,   TSC2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF4↑, 3,   cJun↓, 1,   cJun↑, 2,   cMyc↓, 6,   DNMT1↓, 2,   FOXM1↓, 1,   FOXO↑, 1,   H3↓, 1,   p‑H3↓, 1,   H4↓, 1,   HDAC↓, 1,   HDAC1↓, 1,   HDAC4↓, 1,   miR-133a-3p↑, 1,   Myc↓, 2,   NDRG1↑, 1,   OCT4↓, 2,   other↓, 2,   other↝, 2,   SOX2↓, 1,   SOX4↓, 1,   SPP1↓, 1,   SUV39H↓, 1,   tumCV↓, 7,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 7,   eIF2α↓, 2,   eIF2α↑, 1,   p‑eIF2α↑, 1,   ER Stress↑, 11,   GRP78/BiP↑, 2,   Hsc70↓, 1,   HSP27↓, 1,   HSP70/HSPA5↓, 3,   HSP90↓, 4,   PERK↑, 2,   UPR↑, 4,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG13↑, 1,   ATG16L1↑, 1,   ATG3↑, 1,   ATG5↑, 5,   ATG7↑, 2,   Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 13,   LC3‑Ⅱ/LC3‑Ⅰ↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3B↑, 1,   LC3B-II↑, 1,   LC3II↓, 1,   LC3II↑, 9,   LC3s↑, 1,   p62↓, 1,   p62↑, 1,   RUBCN↓, 1,   TumAuto↑, 16,   ULK1/ATG1↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↓, 1,   ATM↑, 3,   ATR↑, 1,   DFF45↑, 2,   DNA-PK↓, 1,   DNAdam↑, 16,   hTERT/TERT↓, 2,   p16↑, 1,   P53↓, 2,   P53↑, 27,   P53↝, 1,   p‑P53↑, 1,   PARP↑, 9,   cl‑PARP↑, 13,   PARP1↓, 1,   cl‑PARP1↑, 1,   PCNA↓, 6,   Telomerase↓, 3,   TOP1↓, 1,   TOP2↓, 1,   TP53↓, 1,   TP53↑, 1,   TRF2↓, 1,   UHRF1↓, 1,   γH2AX↑, 2,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 3,   CDK2↓, 13,   p‑CDK2↓, 1,   CDK4↓, 14,   CDK4↑, 1,   CDK6↓, 6,   CDK6↑, 2,   CHK1↓, 1,   CHK1↑, 1,   Chk2↑, 1,   cycA1/CCNA1↓, 3,   CycB/CCNB1↓, 8,   CycB/CCNB1↑, 1,   cycD1/CCND1↓, 12,   cycD1/CCND1↑, 1,   cycE/CCNE↓, 7,   cycE/CCNE↑, 1,   cycE1↓, 1,   E2F4↑, 1,   E2Fs↓, 1,   Ki-67↓, 3,   P21↑, 17,   p27/CDKN1B↑, 7,   RB1↑, 3,   p‑RB1↓, 1,   Securin↓, 1,   TumCCA↓, 1,   TumCCA↑, 41,   WEE1↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

4E-BP1↓, 1,   CD133↓, 2,   CD24↓, 1,   CD34↓, 1,   cFos↓, 2,   cFos↑, 1,   CSCs↓, 8,   FBXW7↝, 1,   FGF↓, 3,   HH↓, 1,   IGF-1↓, 3,   Ki-67↓, 3,   mTORC1↓, 1,   Nanog↓, 2,   NOTCH↓, 1,   NOTCH1↓, 5,   NOTCH3↓, 2,   OGFr↑, 1,   STAT1↓, 1,   TumCG?, 1,   TumCG↓, 11,   TumCP↓, 25,   tyrosinase↓, 1,   Wnt↓, 7,   Wnt↑, 1,   ZFX↓, 1,  

Migration(tgid=13) ⓘ

AP-1↓, 3,   ATPase↓, 1,   AXL↓, 2,   Ca+2↑, 14,   Ca+2↝, 1,   CAFs/TAFs↓, 1,   CCN2/CTGF↓, 1,   Cdc42↓, 1,   COL1↓, 2,   COL3A1↓, 1,   DLC1↑, 1,   E-cadherin↓, 4,   E-cadherin↑, 10,   EM↑, 1,   EMT↓, 16,   EMT↑, 2,   FAK↓, 3,   p‑FAK↓, 1,   Fibronectin↓, 1,   GnT-V↝, 1,   heparanase↝, 1,   ITGA5↓, 1,   ITGB1↓, 2,   ITGB6↓, 1,   LEF1↓, 1,   LRP1↓, 1,   MET↓, 1,   p‑MET↓, 1,   MMP-10↓, 1,   MMP1↓, 2,   MMP13↓, 2,   MMP2↓, 22,   MMP3↓, 2,   MMP7↓, 3,   MMP9↓, 23,   MMPs↓, 6,   MTA1↓, 1,   N-cadherin↓, 8,   NM23↑, 1,   PDGF↓, 3,   Rac1↓, 1,   Rho↓, 3,   ROCK1↓, 1,   Slug↓, 4,   SMAD4↓, 1,   Snail?, 1,   Snail↓, 9,   TGF-β↓, 8,   TGF-β1↓, 1,   TIMP1↓, 1,   TIMP1↑, 1,   TIMP2↓, 4,   TIMP2↑, 3,   TIMP3↑, 1,   TSC1↑, 1,   TSP-1↑, 2,   TumCI↓, 14,   TumCMig↓, 13,   TumMeta↓, 12,   TumPF↓, 1,   Twist↓, 8,   Tyro3↓, 1,   uPA↓, 6,   Vim↓, 10,   Vim↑, 1,   Zeb1↓, 3,   Zeb1↑, 1,   ZEB2↓, 2,   β-catenin/ZEB1↓, 13,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 19,   angioG↑, 1,   CD31/PECAM-1↓, 1,   HIF-1↓, 2,   Hif1a↓, 12,   VCAM-1↓, 2,   VEGF↓, 23,   VEGFR2/KDR/Flk1↓, 7,  

Barriers & Transport(tgid=15) ⓘ

CLDN1↓, 1,   EPR↑, 1,   GLUT1↓, 2,   MMP↓, 33,   MMP↑, 1,   MMP↝, 1,   MPT↑, 2,   NHE1↓, 1,   TRPV1↑, 1,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD4+↓, 1,   CD44↓, 6,   CD59↑, 1,   COX2/PTGS2↓, 13,   CXCL1↓, 1,   CXCR4↓, 3,   DR4↑, 3,   HMGB1↓, 1,   ICAM-1↓, 2,   IFN-γ↓, 2,   IL1↓, 3,   IL10↓, 1,   IL12↓, 3,   IL18↓, 1,   IL1β↓, 4,   IL2↓, 2,   IL2↑, 2,   IL4↓, 1,   IL4↑, 1,   IL5↓, 1,   IL6↓, 10,   IL8↓, 4,   Imm↑, 3,   Imm↝, 1,   Inflam↓, 6,   M2 MC↓, 2,   MCP1/CCL2↓, 2,   NF-kB↓, 29,   NF-kB↑, 3,   p‑NF-kB↓, 1,   NLRP3↓, 2,   p50↓, 1,   p65↓, 2,   p‑p65↓, 1,   PD-1↓, 1,   PD-L1↓, 2,   PGE2↓, 3,   PSA↓, 1,   RAGE↓, 2,   TCF↑, 1,   TLR4↓, 1,   TNF-α↓, 12,   TNF-α↑, 2,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 2,   TRADD↑, 1,  

Cellular Microenvironment(tgid=17) ⓘ

IM↓, 1,   PLC↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AhR↑, 1,   AR↓, 3,   AR↑, 1,   ER(estro)↓, 1,   PPARγ↑, 3,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 1,   BioAv↓, 4,   BioAv↑, 4,   BioEnh↑, 1,   ChemoSen↑, 25,   CYP1A1↓, 2,   CYP1A1↑, 1,   CYP1A2↓, 1,   CYP1A2↑, 1,   CYP1B1↑, 1,   CYP2A3/CYP2A6↓, 1,   CYP2E1↑, 1,   CYP3A4↓, 1,   Dose?, 1,   Dose↓, 2,   Dose↑, 1,   Dose↝, 14,   Dose∅, 1,   eff↓, 4,   eff↑, 15,   eff↝, 3,   Half-Life↓, 1,   Half-Life↝, 1,   MDR1↓, 2,   P-gp/ABCB1↓, 4,   P450↓, 3,   P450↝, 1,   RadioS↑, 8,   selectivity↑, 18,   Synergy↑, 17,   TET2↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 1,   ALAT↓, 1,   AR↓, 3,   AR↑, 1,   AST↓, 1,   BMD↑, 1,   CEA↓, 2,   EGFR↓, 9,   EGFR↑, 2,   FOXM1↓, 1,   HEC1↓, 1,   HER2/EBBR2↓, 3,   hTERT/TERT↓, 2,   IL6↓, 10,   LDH↓, 1,   Myc↓, 2,   NOS2↓, 1,   NSE↓, 1,   PD-L1↓, 2,   PSA↓, 1,   RAGE↓, 2,   TP53↓, 1,   TP53↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↓, 1,   AntiCan↑, 11,   antiNeop↑, 1,   AntiTum↑, 5,   cachexia↓, 1,   chemoP↑, 8,   chemoPv↑, 1,   hepatoP↑, 2,   IMPDH1↓, 1,   IMPDH2↓, 1,   neuroP↑, 1,   OS↑, 1,   Pin1↓, 1,   QoL↑, 1,   QoL∅, 1,   RenoP↑, 2,   Risk↓, 4,   Strength↑, 1,   toxicity↓, 2,   toxicity↝, 1,   toxicity∅, 1,  
Total Targets: 571

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 16,   Catalase↑, 9,   GPx↑, 6,   GPx1↑, 1,   GPx4↑, 1,   GSH↑, 9,   GSH/GSSG↑, 1,   GSR↑, 3,   GSTs↑, 3,   HDL↑, 2,   HO-1↓, 1,   HO-1↑, 1,   i-Iron↓, 1,   Keap1↓, 2,   Keap1↑, 1,   lipid-P↓, 8,   MDA↓, 6,   MPO↓, 3,   NQO1↑, 1,   NRF2↑, 7,   ROS↓, 19,   ROS↑, 2,   SOD↑, 12,   SOD1↑, 2,   SOD2↑, 1,   TBARS↓, 2,   uricA↓, 1,   xCT/SLC7A11↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

adiP↓, 1,   ALAT↓, 6,   AMPK↑, 2,   p‑AMPK↑, 2,   ATP↑, 1,   CPT1A↑, 1,   FFA/NEFA↓, 1,   glucose↓, 1,   glucose↝, 1,   H2S↑, 1,   HMG-CoA↓, 3,   LDHA↑, 1,   LDL↓, 3,   lipidLev↓, 1,   NAD↑, 1,   SCD1↓, 1,   SIRT1↑, 2,   SREBP1/SREBF1↓, 3,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 2,   BAX↓, 4,   Bax:Bcl2↑, 2,   Bcl-2↑, 1,   Casp1↓, 1,   Casp3↓, 4,   Casp3↑, 1,   cl‑Casp3↑, 1,   Casp8↑, 1,   cl‑Casp8↑, 1,   Casp9↓, 2,   Casp9↑, 1,   cl‑Casp9↑, 1,   Cyt‑c↓, 3,   Fas↓, 7,   Fas↑, 2,   FasL↓, 1,   Ferroptosis↓, 2,   iNOS↓, 8,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 2,   p‑ERK↑, 1,   HGF/c-Met↑, 1,   MAPK↓, 3,   PI3K↓, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 1,   ATF4↓, 1,   cJun↓, 1,   other↓, 1,   other↑, 3,   other↝, 3,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,   CHOP/DDIT3↑, 1,   ER Stress↓, 1,   GRP78/BiP↑, 1,   GRP94↑, 1,   HSP70/HSPA5↑, 1,   HSPs↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

P53↑, 2,   cl‑PARP↑, 2,   Telomerase↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1,   cycA1/CCNA1↓, 1,   cycE/CCNE↑, 1,   P21↓, 1,   P21↑, 2,   TumCCA↑, 2,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CEBPA↓, 1,   HMGCR↓, 1,  

Migration(tgid=13) ⓘ

AP-1↓, 1,   Ca+2?, 1,   MMP13↓, 1,   MMP9↓, 1,   PAI-1/SERPINE1↓, 1,   TXNIP↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

Hif1a↑, 1,   NO↓, 2,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 2,   GastroP↑, 2,   GLUT2↑, 1,   MMP↓, 2,   MMP↑, 2,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD19↑, 1,   CD4+↑, 2,   CD8+↑, 1,   COX1↓, 1,   COX2/PTGS2↓, 9,   CXCR4↓, 1,   IFN-γ↓, 1,   IL10↑, 2,   IL17↓, 1,   IL18↓, 2,   IL1β↓, 5,   IL2↓, 1,   IL6↓, 5,   IL6↑, 1,   Imm↑, 3,   Inflam↓, 14,   NF-kB↓, 6,   NK cell↑, 1,   NLRP3↓, 2,   PGE2↓, 3,   TLR4↓, 3,   TNF-α↓, 8,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 2,   BChE↓, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,   Aβ↓, 1,   BACE/β-secretase↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

PPARα↑, 2,   PPARγ↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 3,   BioAv↑, 6,   BioAv↝, 2,   Dose⇅, 1,   Dose↝, 5,   eff↑, 3,   eff↝, 1,   GSTA1↑, 1,   Half-Life↝, 3,   P450↓, 1,   Synergy↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 6,   ALP↓, 2,   AST↓, 6,   BP↓, 2,   BUN↓, 1,   colonLen↑, 1,   creat↓, 2,   CRP↓, 2,   IL6↓, 5,   IL6↑, 1,   LDH↓, 5,   TG/TAG↓, 3,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiArt↑, 1,   AntiCan↑, 4,   antiD↓, 1,   AntiDiabetic↑, 2,   cardioP↑, 9,   chemoP↑, 1,   cognitive↑, 2,   hepatoP↑, 10,   memory↑, 2,   motorD↑, 1,   neuroP?, 1,   neuroP↑, 13,   Obesity↓, 2,   Pain↓, 1,   RenoP↑, 5,   Stroke↓, 1,   toxicity↓, 4,   toxicity↑, 1,   toxicity↝, 1,   Weight↓, 1,   Wound Healing↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 2,   AntiFungal↑, 1,   AntiViral↑, 1,   Bacteria↓, 1,   GutMicro↑, 5,   Sepsis↓, 1,  
Total Targets: 191

Scientific Paper Hit Count for: Fas, Fas Death receptor
6 Allicin (mainly Garlic)
5 Hibiscus sabdariffa
4 Luteolin
3 Baicalein
3 Emodin
3 Fisetin
3 Quercetin
2 Astragalus
2 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
2 Propolis -bee glue
2 Chlorogenic acid
2 chitosan
2 Selenium
2 Ferulic acid
2 Indole-3-carbinol
2 Licochalcone A
2 Patchouli Oil (Pogostemon cablin)
2 Silymarin (Milk Thistle) silibinin
1 Silver-NanoParticles
1 Artemisinin
1 Berberine
1 Brucea javanica
1 Beetroot
1 α-Bisabolol / Chamomile oil
1 Caffeic acid
1 Capsaicin
1 Carvacrol
1 Cat’s Claw
1 Celastrol
1 chaetocin
1 Selenate
1 Chrysin
1 Cinnamon
1 Curcumin
1 Date Fruit Extract
1 EGCG (Epigallocatechin Gallate)
1 Electrical Pulses
1 Formononetin
1 Fucoidan
1 Gallic acid
1 Gambogic Acid
1 Garcinol
1 Ginkgo biloba
1 HydroxyCitric Acid
1 tamoxifen
1 HydroxyTyrosol
1 Hyperoside
1 isoorientin
1 Juglone
1 Kaempferol
1 lambertianic acid
1 low dose naltrexone
1 Magnolol
1 Matrine
1 Magnetic Fields
1 Chemotherapy
1 Morin
1 Mushroom Lion’s Mane, Hericium erinaceus
1 Phenethyl isothiocyanate
1 Propyl gallate
1 Phycocyanin
1 Sulforaphane (mainly Broccoli)
1 Thymoquinone
1 Vitamin K2
1 Whole Body Vibration
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:112  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

Home Page