BBB Cancer Research Results

BBB, Blood-Brain Barrier Permeability: Click to Expand ⟱
Source:
Type:
Blood-Brain Barrier(BBB) is a term often used regarding if a product has the ability to cross the BBB.
Scientific Papers found: Click to Expand⟱
5666- BNL,    Exploring the potential to enhance drug distribution in the brain subregion via intranasal delivery of nanoemulsion in combination with borneol as a guider
- in-vivo, AD, NA
*BioAv↑, *eff↑, *Dose↝, *P-gp↓, *BBB↑, *NF-kB↓, *IL1β↓, *MMP9↓,
5667- BNL,    Preparation and evaluation of sustained-release solid dispersions co-loading gastrodin with borneol as an oral brain-targeting enhancer
- in-vivo, Nor, NA
*BioEnh↑, *eff↑, *BBB↑,
5668- BNL,    Anticancer effect of borneol: Mechanistic insights through literature review and in silico studies
- Review, Var, NA
AntiCan↑, Apoptosis↑, mtDam↑, ROS↑, mTORC1↓, EIF4E↓, Hif1a↓, NF-kB↓, STAT3↓, PI3K↓, Akt↓, ChemoSen↑, BioEnh↑, BioAv↑, BBB↑, toxicity↝,
5669- BNL,    Comparison of pharmacological activity and safety of different stereochemical configurations of borneol: L-borneol, D-borneol, and synthetic borneol
- Review, Nor, NA - Review, AD, NA - Review, Stroke, NA
*eff↑, *eff↑, *toxicity↝, *Inflam↓, *Bacteria↓, *neuroP↑, *Half-Life↝, *BBB↑, *BioEnh↑, *P-gp↓, *CYP3A4↓, *ROS↓, *neuroP↑,
5670- BNL,    Advances and perspectives on pharmacological activities and mechanisms of the monoterpene borneol
- Review, Stroke, NA
*TNF-α↓, *NF-kB↓, IL1β↓, MDA↓, BioEnh↑, BBB↑,
2772- Bos,    Mechanistic role of boswellic acids in Alzheimer’s disease: Emphasis on anti-inflammatory properties
- Review, AD, NA
*neuroP↑, *Inflam↓, *AChE↓, *Choline↑, *NRF2↑, *NF-kB↑, *BBB↑, *BioAv↑, *Half-Life↓, *Dose↝, *PGE2↓, *ROS↓, *cognitive↑, *antiOx↑, 5LO↓, *TNF-α↓, *IL6↓, *HO-1↑,
4263- CA,    Neuroprotective Effects of Carnosic Acid: Insight into Its Mechanisms of Action
- Review, AD, NA
*neuroP↑, *ROS↓, *NO↓, *COX2↓, *MAPK↓, *NRF2↑, *GSH↑, *HO-1↑, *5HT↑, *BDNF↑, *PI3K↑, *Akt↑, *NF-kB↑, *BBB↑, *SIRT1↑, *memory↑, *Aβ↓, *NLRP3↓,
4489- Chit,  SeNPs,    Inhibiting Metastasis and Improving Chemosensitivity via Chitosan-Coated Selenium Nanoparticles for Brain Cancer Therapy
- in-vitro, GBM, U87MG
TumCG↓, TumCMig↓, TumCI↓, ChemoSen↑, *BBB↑, eff↑, eff↑, eff↑, selectivity↑, MMP2↓, MMP9↓, EPR↑,
2781- CHr,  PBG,    Chrysin a promising anticancer agent: recent perspectives
- Review, Var, NA
PI3K↓, Akt↓, mTOR↓, MMP9↑, uPA↓, VEGF↓, AR↓, Casp↑, TumMeta↓, TumCCA↑, angioG↓, BioAv↓, *hepatoP↑, *neuroP↑, *SOD↑, *GPx↑, *ROS↓, *Inflam↓, *Catalase↑, *MDA↓, ROS↓, BBB↑, Half-Life↓, BioAv↑, ROS↑, eff↑, ROS↑, ROS↑, lipid-P↑, ER Stress↑, NOTCH1↑, NRF2↓, p‑FAK↓, Rho↓, PCNA↓, COX2↓, NF-kB↓, PDK1↓, PDK3↑, GLUT1↓, Glycolysis↓, mt-ATP↓, Ki-67↓, cMyc↓, ROCK1↓, TOP1↓, TNF-α↓, IL1β↓, CycB/CCNB1↓, CDK2↓, EMT↓, STAT3↓, PD-L1↓, IL2↑,
3888- Cin,    Cinnamon, a promising prospect towards Alzheimer's disease
- NA, AD, NA
*tau↓, *Aβ↓, *neuroP↑, *ROS↓, *Inflam↓, *cardioP↑, *antiOx↑, *cognitive↑, *BBB↑, *p‑GSK‐3β↑, *AChE↓,
3891- Cin,    Identification of potential targets of cinnamon for treatment against Alzheimer's disease-related GABAergic synaptic dysfunction using network pharmacology
- Analysis, AD, NA
*BBB↑, *GABA↑, *eff↑, *antiOx↑, *Inflam↑, *Mood↑,
3624- Cro,    Crocus Sativus L. (Saffron) in Alzheimer's Disease Treatment: Bioactive Effects on Cognitive Impairment
- Review, AD, NA
*AChE↓, *memory↑, *cognitive↑, *MDA↑, *Thiols↑, *GPx↑, *antiOx↑, *ROS↓, *Casp3↓, *neuroP↑, *SOD↑, *Ach↑, *ChAT↑, *BBB↑, *Aβ↓, *tau↓, *cognitive↑, *Inflam↓,
3751- CUR,  Gala,    A Novel Galantamine-Curcumin Hybrid as a Potential Multi-Target Agent against Neurodegenerative Disorders
- in-vivo, AD, NA
*AChE↓, *MDA↑, *GSH↑, *BBB↑,
3857- CUR,    Alpha-Secretase ADAM10 Regulation: Insights into Alzheimer’s Disease Treatment
- Review, AD, NA
*Inflam↓, *antiOx↑, *IronCh↑, *BBB↑, *ADAM10↝,
3590- CUR,    The Holy Grail of Curcumin and its Efficacy in Various Diseases: Is Bioavailability Truly a Big Concern?
- Review, Var, NA - Review, AD, NA
*BioAv↓, *BioAv↑, Dose↑, *Dose↝, *BBB↑, *cognitive↑, *BioAv↑,
3588- CUR,    The effect of curcumin on cognition in Alzheimer’s disease and healthy aging: A systematic review of pre-clinical and clinical studies
- Review, AD, NA
*cognitive↝, *BioAv↑, *Inflam↓, *COX2↓, *iNOS↓, *NF-kB↓, *TNF-α↓, *IL1↓, *IL2↓, *IL6↓, *IL8↓, *IL12↓, *ROS↓, *RNS↓, *antiOx↑, *BBB↑, *BioAv↓, *cognitive↑, *memory↑, *tau↓, *eff↑,
3581- CUR,    Curcumin Attenuated Neurotoxicity in Sporadic Animal Model of Alzheimer's Disease
- NA, AD, NA
*antiOx↑, *Inflam↓, *BBB↑, *NRF2↑, *NF-kB↓, *cognitive↑, *ROS↓, *MDA↓, *SOD↑, *Catalase↑, *INF-γ↓, *IL4↓, *memory↑, *TNF-α↓, *IL1β↓,
3576- CUR,    Protective Effects of Indian Spice Curcumin Against Amyloid-β in Alzheimer's Disease
- Review, AD, NA
*Inflam↓, *antiOx↑, *memory↑, *Aβ↓, *BBB↑, *cognitive↑, *tau↓, *LDL↓, *AChE↓, *IL1β↓, *IronCh↑, *neuroP↑, *BioAv↝, *PI3K↑, *Akt↑, *NRF2↑, *HO-1↑, *Ferritin↑, *HO-2↓, *ROS↓, *Ach↑, *GSH↑, *Bcl-2↑, *ChAT↑,
3574- CUR,    The effect of curcumin (turmeric) on Alzheimer's disease: An overview
- Review, AD, NA
*antiOx↑, *Inflam↓, *lipid-P↓, *cognitive↑, *memory↑, *Aβ↓, *COX2↓, *ROS↓, *AP-1↓, *NF-kB↓, *TNF-α↓, *IL1β↓, *SOD↑, *GSH↑, *HO-1↑, *IronCh↑, *BioAv↓, *Half-Life↝, *Dose↝, *BBB↑, *BioAv↑, *toxicity∅, *eff↑,
4291- EGCG,    Structure-based discovery of small molecules that disaggregate Alzheimer’s disease tissue derived tau fibrils in vitro
- in-vitro, AD, NA
*tau↓, *BBB∅,
1516- EGCG,    Epigallocatechin Gallate (EGCG): Pharmacological Properties, Biological Activities and Therapeutic Potential
- Review, NA, NA
*Dose∅, Half-Life∅, BioAv∅, BBB↑, toxicity∅, eff↓, Apoptosis↑, Casp3↑, Cyt‑c↑, cl‑PARP↑, DNMTs↓, Telomerase↓, angioG↓, Hif1a↓, NF-kB↓, MMPs↓, BAX↑, Bak↑, Bcl-2↓, Bcl-xL↓, P53↑, PTEN↑, IGF-1↓, H3↓, HDAC1↓, *LDH↓, *ROS↓,
3201- EGCG,    Epigallocatechin Gallate (EGCG): Pharmacological Properties, Biological Activities and Therapeutic Potential
- Review, NA, NA
*AntiCan↑, *cardioP↑, *neuroP↑, *BioAv↝, *BioAv↓, *BioAv↓, *Dose↝, *Half-Life↝, *BioAv↑, *BBB↑, *hepatoP↓, *other↓, *Inflam↓, *NF-kB↓, *AP-1↓, *iNOS↓, *COX2↓, *ROS↓, *RNS↓, *IL8↓, *JAK↓, *PDGFR-BB↓, *IGF-1R↓, *MMP2↓, *P53↓, *NRF2↑, *TNF-α↓, *IL6↓, *E2Fs↑, *SOD1↑, *SOD2↑, Casp3↑, Cyt‑c↑, PARP↑, DNMTs↓, Telomerase↓, Hif1a↓, MMPs↓, BAX↑, Bak↑, Bcl-2↓, Bcl-xL↓, P53↑, PTEN↑, TumCP↓, MAPK↓, HGF/c-Met↓, TIMP1↑, HDAC↓, MMP9↓, uPA↓, GlutMet↓, ChemoSen↑, chemoP↑,
3783- FA,    Design, Synthesis, and Biological Evaluation of Ferulic Acid-Piperazine Derivatives Targeting Pathological Hallmarks of Alzheimer’s Disease
- NA, AD, NA
*ROS↓, *IronCh↑, *NLRP3↓, *Aβ↓, *AChE↓, *BChE↓, *antiOx↑, *BBB↑, *MMP↑, *memory↑, *SOD↑, *Catalase↑,
3781- FA,    Therapeutic potential of ferulic acid and its derivatives in Alzheimer’s disease—A systematic review
- Review, AD, NA
*antiOx↑, *Inflam↓, *BBB↑, *AChE↓, *BChE↓,
3717- FA,    Neuroprotective Properties of Ferulic Acid in Preclinical Models of Alzheimer's Disease: A Systematic Literature Review
- Review, AD, NA
*toxicity↓, *BBB↑, *Aβ↓, *antiOx↑, *Inflam↓, *neuroP↑,
2854- FIS,    New Perspectives for Fisetin
- Review, Var, NA - Review, Stroke, NA
Inflam↓, ChemoSen↑, chemoPv↑, eff↑, memory↑, neuroP↑, *Dose↑, BioAv↓, BBB↑,
2861- FIS,    The neuroprotective effects of fisetin, a natural flavonoid in neurodegenerative diseases: Focus on the role of oxidative stress
- Review, Nor, NA - Review, Stroke, NA - Review, Park, NA
*antiOx↑, *ROS↓, *neuroP↑, *NO↑, BioAv↝, *BBB↑, *toxicity↑, *eff↑, *GSH↑, *SOD↑, *Aβ↓, *12LOX↓, *COX2↓, *Catalase↑, *Inflam↓, *TNF-α↓, *IL6↑, *lipid-P↓, NF-kB↓, IL1β↓, NRF2↑, HO-1↑, GSTs↑, cognitive↑, *BDNF↑,
5148- GamB,    Gambogic acid: A shining natural compound to nanomedicine for cancer therapeutics
- Review, Var, NA
AntiCan↑, angioG↓, ChemoSen↑, RadioS↑, VEGF↓, MMP2↓, MMP9↓, Telomerase↓, TrxR↓, ERK↓, HSP90↓, ROS↑, SIRT1↑, survivin↓, cFLIP↓, Casp3↑, Casp8↑, Casp9↑, BAD↓, BID↓, Bcl-2↓, BAX↑, STAT3↓, hTERT/TERT↓, NF-kB↓, Myc↓, Hif1a↓, FOXD3↑, BioAv↓, BioAv↑, P53↑, eff↓, OCR↓, MMP↓, PI3K↓, Akt↓, BBB↑, TumCG↓, TumMeta↓, BioAv↑,
3721- Gb,    Ginkgo biloba Extract in Alzheimer’s Disease: From Action Mechanisms to Medical Practice
- Review, AD, NA
*antiOx↑, *ROS↓, *SOD↑, *Catalase↑, *GSR↑, *MMP↑, *Inflam↓, *Aβ↓, *memory↑, *Dose↝, *BBB↑, *neuroP↑,
4307- H2,    Hydrogen Gas Attenuates Toxic Metabolites and Oxidative Stress-Mediated Signaling to Inhibit Neurodegeneration and Enhance Memory in Alzheimer’s Disease Models
- in-vivo, AD, NA
*cognitive↑, *Inflam↓, *ROS↓, *neuroP↑, *memory↑, *BBB↑, *BDNF↑, *TNF-α↓, *Catalase↑, *IL6↓, *Aβ↓, *GABA↓, *Dose↝,
2511- H2,    Molecular hydrogen suppresses glioblastoma growth via inducing the glioma stem-like cell differentiation
- in-vivo, GBM, U87MG
TumCG↓, OS↑, CD133↓, Ki-67↓, angioG↓, Diff↑, TumCMig↓, TumCI↓, Dose↝, BBB↑, mt-ROS↑,
2519- H2,    Hydrogen: an advanced and safest gas option for cancer treatment
- Review, Var, NA
antiOx↑, neuroP↓, BBB↑, toxicity∅, TumCP↓, Apoptosis↓, ROS↑, Hif1a↓, NF-kB↓, P53?, OS↑, chemoP↑,
2513- H2,    Hydrogen therapy: from mechanism to cerebral diseases
- Review, Stroke, NA
*BBB?, *antiOx↑, *Inflam↓, *Apoptosis↓, *NF-kB↓, *Dose↝,
3761- H2,    Therapeutic Inhalation of Hydrogen Gas for Alzheimer's Disease Patients and Subsequent Long-Term Follow-Up as a Disease-Modifying Treatment: An Open Label Pilot Study
- Human, AD, NA
*cognitive↑, *BBB↑, *ROS↓, *NRF2↑, *Inflam↓, *NFAT↓, *FAO↓, *4-HNE↓, *PGC-1α↑, *Ferroptosis↓,
3771- H2,    Molecular Hydrogen Neuroprotection in Post-Ischemic Neurodegeneration in the Form of Alzheimer’s Disease Proteinopathy: Underlying Mechanisms and Potential for Clinical Implementation—Fantasy or Reality?
- Review, AD, NA - Review, Stroke, NA
*cognitive↑, AntiCan↑, *Inflam↓, *antiOx↑, *ROS↓, *neuroP↑, *SOD↑, *GPx↑, *MDA↑, *BBB↑, *OS↑, *Ca+2↓, *APP↓, *p‑tau↓,
3773- H2,    Role and mechanism of molecular hydrogen in the treatment of Parkinson’s diseases
- Review, Park, NA
*neuroP↑, *antiOx↑, *Inflam↓, *ROS↓, *NADPH↓, *NRF2↑, *BBB↑, *IL1β↓, *IL6↓, *TNF-α↓, *NF-kB↓, *NLRP3↓, *Sepsis↓, *p‑mTOR↓, *AMPK↑, *SIRT1↑, *HO-1↑,
3765- H2,    Therapeutic Inhalation of Hydrogen Gas for Alzheimer’s Disease Patients and Subsequent Long-Term Follow-Up as a Disease-Modifying Treatment: An Open Label Pilot Study
- Study, AD, NA
*antiOx↑, *Inflam↓, *cognitive↑, *BBB↑,
3767- H2,    The role of hydrogen therapy in Alzheimer's disease management: Insights into mechanisms, administration routes, and future challenges
- Review, AD, NA
*Inflam↓, *neuroP↑, *toxicity↓, *antiOx↑, *ROS↓, *NLRP3↓, *IL1β↓, *mtDam↓, *ATP↑, *AMPK↑, *FOXO3↑, *SOD1↑, *Catalase↑, *NRF2↑, *NO↓, *MDA↓, *lipid-P↓, *memory↑, *ER(estro)↓, *BDNF↑, *cognitive↑, *APP↓, *BACE↓, *Aβ↓, *BP∅, *BBB↑,
2883- HNK,    Honokiol targets mitochondria to halt cancer progression and metastasis
- Review, Var, NA
ChemoSen↑, BBB↓, Ca+2↑, Cyt‑c↑, Casp3↑, chemoPv↑, OCR↓, mitResp↓, Apoptosis↑, RadioS↑, NF-kB↓, Akt↓, TNF-α↓, PGE2↓, VEGF↓, NO↝, COX2↓, RAS↓, EMT↓, Snail↓, N-cadherin↓, β-catenin/ZEB1↓, E-cadherin↑, ER Stress↑, p‑STAT3↓, EGFR↓, mTOR↓, mt-ROS↑, PI3K↓, Wnt↓,
2873- HNK,    Honokiol Alleviates Oxidative Stress-Induced Neurotoxicity via Activation of Nrf2
- in-vitro, Nor, PC12
*neuroP↑, *GSH↑, *HO-1↑, *NADPH↑, *Trx1↑, *TrxR1↑, *NRF2↑, *ROS↓, *antiOx↑, *BBB↑, Dose↓,
2872- HNK,    Honokiol alleviated neurodegeneration by reducing oxidative stress and improving mitochondrial function in mutant SOD1 cellular and mouse models of amyotrophic lateral sclerosis
- in-vivo, ALS, NA - NA, Stroke, NA - NA, AD, NA - NA, Park, NA
*eff↑, *ROS↓, *GSH↑, *NRF2↑, *motorD↑, *OS↑, *neuroP↑, *BBB↑, *cognitive↑, *eff↑, *antiOx↑, *Cyt‑c↑, *PGC-1α↑,
2866- HNK,    Honokiol and its analogues as anticancer compounds: Current mechanistic insights and structure-activity relationship
- Review, Var, NA
EMT↓, TumMeta↓, BioAv↑, BBB↑,
2864- HNK,    Honokiol: A Review of Its Anticancer Potential and Mechanisms
- Review, Var, NA
TumCCA↑, CDK2↓, EMT↓, MMPs↓, AMPK↑, TumCI↓, TumCMig↓, TumMeta↓, VEGFR2↓, *antiOx↑, *Inflam↓, *BBB↑, *neuroP↑, *ROS↓, Dose↝, selectivity↑, Casp3↑, Casp9↑, NOTCH1↓, cycD1/CCND1↓, cMyc↓, P21?, DR5↑, cl‑PARP↑, P53↑, Mcl-1↑, p65↓, NF-kB↓, ROS↑, JNK↑, NRF2↑, cJun↑, EF-1α↓, MAPK↓, PI3K↓, mTORC1↓, CSCs↓, OCT4↓, Nanog↓, SOX4↓, STAT3↓, CDK4↓, p‑RB1↓, PGE2↓, COX2↓, β-catenin/ZEB1↑, IKKα↓, HDAC↓, HATs↑, H3↑, H4↑, LC3II↑, c-Raf↓, SIRT3↑, Hif1a↓, ER Stress↑, GRP78/BiP↑, cl‑CHOP↑, MMP↓, PCNA↓, Zeb1↓, NOTCH3↓, CD133↓, Nestin↓, ATG5↑, ATG7↑, survivin↓, ChemoSen↑, SOX2↓, OS↑, P-gp↓, Half-Life↓, Half-Life↝, eff↑, BioAv↓,
2885- HNK,    Honokiol: a novel natural agent for cancer prevention and therapy
NF-kB↓, STAT3↓, EGFR↓, mTOR↓, BioAv↝, Inflam↓, TumCP↓, angioG↓, TumCI↓, TumMeta↓, cSrc↓, JAK1↓, JAK2↓, ERK↓, Akt↓, PTEN↑, ChemoSen↑, chemoP↑, COX2↓, PGE2↓, TNF-α↓, IL1β↓, IL6↓, Casp3↑, Casp8↑, Casp9↑, cl‑PARP↑, DNAdam↑, Cyt‑c↑, RadioS↑, RAS↓, BBB↑, BioAv↓, Half-Life↝, Half-Life↝, toxicity↓,
2894- HNK,    Pharmacological features, health benefits and clinical implications of honokiol
- Review, Var, NA - Review, AD, NA
*BioAv↓, *neuroP↑, *BBB↑, *ROS↓, *Keap1↑, *NRF2↑, *Casp3↓, *SIRT3↑, *Rho↓, *ERK↓, *NF-kB↓, angioG↓, RAS↓, PI3K↓, Akt↓, mTOR↓, *memory↑, *Aβ↓, *PPARγ↑, *PGC-1α↑, NF-kB↓, Hif1a↓, VEGF↓, HO-1↓, FOXM1↓, p27↑, P21↑, CDK2↓, CDK4↓, CDK6↓, cycD1/CCND1↓, Twist↓, MMP2↓, Rho↑, ROCK1↑, TumCMig↓, cFLIP↓, BMPs↑, OCR↑, ECAR↓, *AntiAg↑, *cardioP↑, *antiOx↑, *ROS↓, P-gp↓,
3803- Hup,    Huperzine A and Its Neuroprotective Molecular Signaling in Alzheimer’s Disease
- Review, AD, NA
*AChE↓, *neuroP↑, *BBB↑, *Half-Life↑, *cognitive↑, *Dose↝, *BACE↓, *IronCh↑, *TfR1/CD71↓, *ROS↓,
4295- LT,    Luteolin Reduces Alzheimer’s Disease Pathologies Induced by Traumatic Brain Injury
- in-vivo, AD, NA
*Aβ↓, *GSK‐3β↓, *p‑tau↓, *BBB↑,
4292- LT,    Luteolin for neurodegenerative diseases: a review
- Review, AD, NA - Review, Park, NA - Review, MS, NA - Review, Stroke, NA
*Inflam↓, *antiOx↑, *neuroP↑, *BioAv↝, *BBB↑, *TNF-α↓, *IL1β↓, *IL6↓, *IL8↓, *IL33↓, *NF-kB↓, *BACE↓, *ROS↓, *SOD↑, *HO-1↑, *NRF2↑, *Casp3↓, *Casp9↑, *Bax:Bcl2↓, *UPR↑, *GRP78/BiP↑, *Aβ↓, *GSK‐3β↓, *tau↓, *CREB↑, *ATP↑, *cognitive↑, *BloodF↑, *BDNF↑, *TrkB↑, *memory↑, *PPARγ↑, *eff↑,
2916- LT,    Antioxidative and Anticancer Potential of Luteolin: A Comprehensive Approach Against Wide Range of Human Malignancies
- Review, Var, NA - Review, AD, NA - Review, Park, NA
proCasp9↓, CDC2↓, CycB/CCNB1↓, Casp9↑, Casp3↑, Cyt‑c↑, cycA1/CCNA1↑, CDK2↓, APAF1↑, TumCCA↑, P53↑, BAX↑, VEGF↓, Bcl-2↓, Apoptosis↑, p‑Akt↓, p‑EGFR↓, p‑ERK↓, p‑STAT3↓, cardioP↑, Catalase↓, SOD↓, *BioAv↓, *antiOx↑, *ROS↓, *NO↓, *GSTs↑, *GSR↑, *SOD↑, *Catalase↑, *lipid-P↓, PI3K↓, Akt↓, CDK2↓, BNIP3↑, hTERT/TERT↓, DR5↑, Beclin-1↑, TNF-α↓, NF-kB↓, IL1↓, IL6↓, EMT↓, FAK↓, E-cadherin↑, MDM2↓, NOTCH↓, MAPK↑, Vim↓, N-cadherin↓, Snail↓, MMP2↓, Twist↓, MMP9↓, ROS↑, MMP↓, *AChE↓, *MMP↑, *Aβ↓, *neuroP↑, Trx1↑, ROS↓, *NRF2↑, NRF2↓, *BBB↑, ChemoSen↑, GutMicro↑,
3528- Lyco,    The Importance of Antioxidant Activity for the Health-Promoting Effect of Lycopene
- Review, Nor, NA - Review, AD, NA - Review, Park, NA
*antiOx↑, *ROS↓, *BioAv↝, *Half-Life↑, *BioAv↓, *BioAv↑, *cardioP↑, *neuroP↑, *H2O2↓, *VitC↑, *VitE↑, *GPx↑, *GSH↑, *MPO↓, *GSTs↓, *SOD↑, *NF-kB↓, *IL1β↓, *IL6↓, *IL10↑, *MAPK↓, *Akt↓, *COX2↓, *TNF-α↓, *TGF-β1↑, *NO↓, *GSR↑, *NRF2↑, *HO-1↑, *TAC↑, *Inflam↓, *BBB↑, *neuroP↑, *memory↑,

Showing Research Papers: 51 to 100 of 151
Prev Page 2 of 4 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 151

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,   Catalase↓, 1,   GSTs↑, 1,   HO-1↓, 1,   HO-1↑, 1,   lipid-P↑, 1,   MDA↓, 1,   NRF2↓, 2,   NRF2↑, 2,   ROS↓, 2,   ROS↑, 8,   mt-ROS↑, 2,   SIRT3↑, 1,   SOD↓, 1,   Trx1↑, 1,   TrxR↓, 1,  

Mitochondria & Bioenergetics ⓘ

mt-ATP↓, 1,   CDC2↓, 1,   mitResp↓, 1,   MMP↓, 3,   mtDam↑, 1,   OCR↓, 2,   OCR↑, 1,   c-Raf↓, 1,  

Core Metabolism/Glycolysis ⓘ

AMPK↑, 1,   ATG7↑, 1,   cMyc↓, 2,   ECAR↓, 1,   GlutMet↓, 1,   Glycolysis↓, 1,   PDK1↓, 1,   PDK3↑, 1,   SIRT1↑, 1,  

Cell Death ⓘ

Akt↓, 7,   p‑Akt↓, 1,   APAF1↑, 1,   Apoptosis↓, 1,   Apoptosis↑, 4,   BAD↓, 1,   Bak↑, 2,   BAX↑, 4,   Bcl-2↓, 4,   Bcl-xL↓, 2,   BID↓, 1,   Casp↑, 1,   Casp3↑, 7,   Casp8↑, 2,   Casp9↑, 4,   proCasp9↓, 1,   cFLIP↓, 2,   Cyt‑c↑, 5,   DR5↑, 2,   HGF/c-Met↓, 1,   hTERT/TERT↓, 2,   JNK↑, 1,   MAPK↓, 2,   MAPK↑, 1,   Mcl-1↑, 1,   MDM2↓, 1,   Myc↓, 1,   p27↑, 1,   survivin↓, 2,   Telomerase↓, 3,  

Kinase & Signal Transduction ⓘ

cSrc↓, 1,   EF-1α↓, 1,   FOXD3↑, 1,  

Transcription & Epigenetics ⓘ

cJun↑, 1,   H3↓, 1,   H3↑, 1,   H4↑, 1,   HATs↑, 1,  

Protein Folding & ER Stress ⓘ

cl‑CHOP↑, 1,   ER Stress↑, 3,   GRP78/BiP↑, 1,   HSP90↓, 1,  

Autophagy & Lysosomes ⓘ

ATG5↑, 1,   Beclin-1↑, 1,   BNIP3↑, 1,   LC3II↑, 1,  

DNA Damage & Repair ⓘ

DNAdam↑, 1,   DNMTs↓, 2,   P53?, 1,   P53↑, 5,   PARP↑, 1,   cl‑PARP↑, 3,   PCNA↓, 2,  

Cell Cycle & Senescence ⓘ

CDK2↓, 5,   CDK4↓, 2,   cycA1/CCNA1↑, 1,   CycB/CCNB1↓, 2,   cycD1/CCND1↓, 2,   P21?, 1,   P21↑, 1,   p‑RB1↓, 1,   TumCCA↑, 3,  

Proliferation, Differentiation & Cell State ⓘ

CD133↓, 2,   CSCs↓, 1,   Diff↑, 1,   EIF4E↓, 1,   EMT↓, 5,   ERK↓, 2,   p‑ERK↓, 1,   FOXM1↓, 1,   HDAC↓, 2,   HDAC1↓, 1,   IGF-1↓, 1,   mTOR↓, 4,   mTORC1↓, 2,   Nanog↓, 1,   Nestin↓, 1,   NOTCH↓, 1,   NOTCH1↓, 1,   NOTCH1↑, 1,   NOTCH3↓, 1,   OCT4↓, 1,   PI3K↓, 7,   PTEN↑, 3,   RAS↓, 3,   SOX2↓, 1,   STAT3↓, 5,   p‑STAT3↓, 2,   TOP1↓, 1,   TumCG↓, 3,   Wnt↓, 1,  

Migration ⓘ

5LO↓, 1,   Ca+2↑, 1,   E-cadherin↑, 2,   FAK↓, 1,   p‑FAK↓, 1,   Ki-67↓, 2,   MMP2↓, 4,   MMP9↓, 4,   MMP9↑, 1,   MMPs↓, 3,   N-cadherin↓, 2,   Rho↓, 1,   Rho↑, 1,   ROCK1↓, 1,   ROCK1↑, 1,   Snail↓, 2,   SOX4↓, 1,   TIMP1↑, 1,   TumCI↓, 4,   TumCMig↓, 4,   TumCP↓, 3,   TumMeta↓, 5,   Twist↓, 2,   uPA↓, 2,   Vim↓, 1,   Zeb1↓, 1,   β-catenin/ZEB1↓, 1,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 6,   EGFR↓, 2,   p‑EGFR↓, 1,   EPR↑, 1,   Hif1a↓, 7,   NO↝, 1,   VEGF↓, 5,   VEGFR2↓, 1,  

Barriers & Transport ⓘ

BBB↓, 1,   BBB↑, 10,   GLUT1↓, 1,   P-gp↓, 2,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 4,   IKKα↓, 1,   IL1↓, 1,   IL1β↓, 4,   IL2↑, 1,   IL6↓, 2,   Inflam↓, 2,   JAK1↓, 1,   JAK2↓, 1,   NF-kB↓, 11,   p65↓, 1,   PD-L1↓, 1,   PGE2↓, 3,   TNF-α↓, 4,  

Hormonal & Nuclear Receptors ⓘ

AR↓, 1,   CDK6↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 5,   BioAv↑, 5,   BioAv↝, 2,   BioAv∅, 1,   BioEnh↑, 2,   ChemoSen↑, 9,   Dose↓, 1,   Dose↑, 1,   Dose↝, 2,   eff↓, 2,   eff↑, 6,   Half-Life↓, 2,   Half-Life↝, 3,   Half-Life∅, 1,   RadioS↑, 3,   selectivity↑, 2,  

Clinical Biomarkers ⓘ

AR↓, 1,   BMPs↑, 1,   EGFR↓, 2,   p‑EGFR↓, 1,   FOXM1↓, 1,   GutMicro↑, 1,   hTERT/TERT↓, 2,   IL6↓, 2,   Ki-67↓, 2,   Myc↓, 1,   PD-L1↓, 1,  

Functional Outcomes ⓘ

AntiCan↑, 3,   cardioP↑, 1,   chemoP↑, 3,   chemoPv↑, 2,   cognitive↑, 1,   memory↑, 1,   neuroP↓, 1,   neuroP↑, 1,   OS↑, 3,   toxicity↓, 1,   toxicity↝, 1,   toxicity∅, 2,  
Total Targets: 219

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

4-HNE↓, 1,   antiOx↑, 26,   Catalase↑, 8,   Ferroptosis↓, 1,   GPx↑, 4,   GSH↑, 8,   GSR↑, 3,   GSTs↓, 1,   GSTs↑, 1,   H2O2↓, 1,   HO-1↑, 8,   HO-2↓, 1,   Keap1↑, 1,   lipid-P↓, 4,   MDA↓, 3,   MDA↑, 3,   MPO↓, 1,   NRF2↑, 14,   RNS↓, 2,   ROS↓, 29,   SIRT3↑, 1,   SOD↑, 11,   SOD1↑, 2,   SOD2↑, 1,   TAC↑, 1,   Thiols↑, 1,   Trx1↑, 1,   TrxR1↑, 1,   VitC↑, 1,   VitE↑, 1,  

Metal & Cofactor Biology ⓘ

Ferritin↑, 1,   IronCh↑, 5,   TfR1/CD71↓, 1,  

Mitochondria & Bioenergetics ⓘ

ATP↑, 2,   MMP↑, 3,   mtDam↓, 1,   PGC-1α↑, 3,  

Core Metabolism/Glycolysis ⓘ

12LOX↓, 1,   AMPK↑, 2,   CREB↑, 1,   CYP3A4↓, 1,   FAO↓, 1,   LDH↓, 1,   LDL↓, 1,   NADPH↓, 1,   NADPH↑, 1,   PPARγ↑, 2,   SIRT1↑, 2,  

Cell Death ⓘ

Akt↓, 1,   Akt↑, 2,   Apoptosis↓, 1,   Bax:Bcl2↓, 1,   Bcl-2↑, 1,   Casp3↓, 3,   Casp9↑, 1,   Cyt‑c↑, 1,   Ferroptosis↓, 1,   iNOS↓, 2,   MAPK↓, 2,  

Transcription & Epigenetics ⓘ

Ach↑, 2,   other↓, 1,  

Protein Folding & ER Stress ⓘ

GRP78/BiP↑, 1,   UPR↑, 1,  

DNA Damage & Repair ⓘ

P53↓, 1,  

Cell Cycle & Senescence ⓘ

E2Fs↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

Choline↑, 1,   ERK↓, 1,   FOXO3↑, 1,   GSK‐3β↓, 2,   p‑GSK‐3β↑, 1,   IGF-1R↓, 1,   p‑mTOR↓, 1,   PI3K↑, 2,  

Migration ⓘ

AntiAg↑, 1,   AP-1↓, 2,   APP↓, 2,   Ca+2↓, 1,   MMP2↓, 1,   MMP9↓, 1,   NFAT↓, 1,   Rho↓, 1,   TGF-β1↑, 1,  

Angiogenesis & Vasculature ⓘ

NO↓, 4,   NO↑, 1,   PDGFR-BB↓, 1,  

Barriers & Transport ⓘ

BBB?, 1,   BBB↑, 37,   BBB∅, 1,   P-gp↓, 2,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 6,   IL1↓, 1,   IL10↑, 1,   IL12↓, 1,   IL1β↓, 8,   IL2↓, 1,   IL33↓, 1,   IL4↓, 1,   IL6↓, 7,   IL6↑, 1,   IL8↓, 3,   INF-γ↓, 1,   Inflam↓, 25,   Inflam↑, 1,   JAK↓, 1,   NF-kB↓, 11,   NF-kB↑, 2,   PGE2↓, 1,   TNF-α↓, 11,  

Synaptic & Neurotransmission ⓘ

5HT↑, 1,   AChE↓, 9,   ADAM10↝, 1,   BChE↓, 2,   BDNF↑, 5,   ChAT↑, 2,   GABA↓, 1,   GABA↑, 1,   tau↓, 6,   p‑tau↓, 2,   TrkB↑, 1,  

Protein Aggregation ⓘ

Aβ↓, 15,   BACE↓, 3,   NLRP3↓, 4,  

Hormonal & Nuclear Receptors ⓘ

ER(estro)↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 8,   BioAv↑, 8,   BioAv↝, 4,   BioEnh↑, 2,   Dose↑, 1,   Dose↝, 9,   Dose∅, 1,   eff↑, 11,   Half-Life↓, 1,   Half-Life↑, 2,   Half-Life↝, 3,  

Clinical Biomarkers ⓘ

BloodF↑, 1,   BP∅, 1,   Ferritin↑, 1,   IL6↓, 7,   IL6↑, 1,   LDH↓, 1,  

Functional Outcomes ⓘ

AntiCan↑, 1,   cardioP↑, 4,   cognitive↑, 17,   cognitive↝, 1,   hepatoP↓, 1,   hepatoP↑, 1,   memory↑, 13,   Mood↑, 1,   motorD↑, 1,   neuroP↑, 25,   OS↑, 2,   toxicity↓, 2,   toxicity↑, 1,   toxicity↝, 1,   toxicity∅, 1,  

Infection & Microbiome ⓘ

Bacteria↓, 1,   Sepsis↓, 1,  
Total Targets: 157

Scientific Paper Hit Count for: BBB, Blood-Brain Barrier Permeability
13 Alpha-Lipoic-Acid
11 borneol
9 Hydrogen Gas
7 Curcumin
7 Honokiol
5 Pterostilbene
5 Urolithin
4 Silver-NanoParticles
4 Berberine
4 Quercetin
3 5-Hydroxytryptophan
3 Apigenin (mainly Parsley)
3 EGCG (Epigallocatechin Gallate)
3 Ferulic acid
3 Luteolin
3 Lycopene
3 Mushroom Lion’s Mane
3 Rutin
3 Sulforaphane (mainly Broccoli)
2 almonertinib
2 Baicalein
2 beta-carotene(VitA)
2 Bacopa monnieri
2 Selenium NanoParticles
2 Cinnamon
2 Fisetin
2 Methylene blue
2 Vitamin B3,Niacin
2 Resveratrol
2 Rosmarinic acid
2 S-adenosyl-L-methionine
2 Silymarin (Milk Thistle) silibinin
2 Thymoquinone
2 Vitamin B5,Pantothenic Acid
1 acetaminophen
1 Anthocyanins
1 Allicin (mainly Garlic)
1 Acetyl-l-carnitine
1 Bevacizumab (brand Avastin)
1 Aromatherapy
1 Ashwagandha(Withaferin A)
1 Astaxanthin
1 Baicalin
1 Betulinic acid
1 Brucea javanica
1 Boswellia (frankincense)
1 Carnosic acid
1 chitosan
1 Chrysin
1 Propolis -bee glue
1 Crocetin
1 Galantamine
1 Gambogic Acid
1 Ginkgo biloba
1 Huperzine A/Huperzia serrata
1 Magnolol
1 MCToil
1 Melatonin
1 Magnetic Fields
1 Moringa oleifera
1 Methylsulfonylmethane
1 Myrrh
1 nicotinamide adenine dinucleotide
1 Taurine
1 Vitamin C (Ascorbic Acid)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1123  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

Home Page