Ferroptosis Cancer Research Results

Ferroptosis, Ferroptosis: Click to Expand ⟱
Source:
Type: type of cell death
Type of programmed cell death dependent on iron.
Ferroptosis is a form of regulated cell death characterized by the accumulation of lipid peroxides to lethal levels. It is distinct from other forms of cell death, such as apoptosis, necrosis, and autophagy. The process of ferroptosis is heavily dependent on iron metabolism and reactive oxygen species (ROS).
The accumulation of lipid peroxides is a hallmark of ferroptosis. This can occur when the antioxidant defenses, such as glutathione and selenoproteins, are overwhelmed or inhibited. Many cancer cells upregulate GPX4 to evade ferroptosis, making it a potential target for therapy. It has been described that GPX4, xCT and ACSL-4 are the main targets in the regulation of ferroptosis.
Scientific Papers found: Click to Expand⟱
2315- Citrate,  immuno,    Why and how citrate may sensitize malignant tumors to immunotherapy
- Review, Var, NA
Bcl-2↓, Mcl-1↓, survivin↓, Casp3↑, Casp9↑, Ferroptosis↑, lipid-P↑, Ca+2↓, Akt↓, mTOR↓, Hif1a↓, MCU↓, ATP↓, ROS↑, eff↑,
4770- CoQ10,  VitK2,    Cancer cell stiffening via CoQ10 and UBIAD1 regulates ECM signaling and ferroptosis in breast cancer
- in-vitro, BC, MDA-MB-231
other↑, *antiOx↑, Risk↓, other↑, TumMeta↓, ECM/TCF↓, Akt2↓, Ferroptosis↑, eff↑,
6156- CoQ10,    Metabolic Regulation of Ferroptosis in Breast Cancer
- Review, Var, NA
other↝, Ferroptosis↑, GPx4↓,
6314- Cro,    Crocin promotes ferroptosis in gastric cancer via the Nrf2/GGTLC2 pathway
- in-vitro, GC, NA
TumCP↓, TumCMig↓, TumCI↓, Apoptosis↓, antiOx↓, Ferroptosis↑, NRF2↑, P53↑, TumCCA↑, ChemoSen↑, EMT↓, Hif1a↓, ROS↑,
6182- Cu,    Role of cuproptosis in digestive system tumors (Review)
- Review, Var, NA
Cupro↑, TumCG↓, Apoptosis↑, ROS↑, Ferroptosis↑, ETC↓, MMP↓, Ca+2↑, Fenton↑, lipid-P↑, MPT↑, ATP↓, Cyt‑c↑, Casp↑, angioG↑, TumCP↑, TumCMig↑, TumCI↑, TumMeta↑, DDS↑, eff↑,
1600- Cu,    Cu(II) complex that synergistically potentiates cytotoxicity and an antitumor immune response by targeting cellular redox homeostasis
- Review, NA, NA
ER Stress↑, ROS↑, AntiTum↑, GSH↓, Ferroptosis↑, selectivity↑, GSH/GSSG↓, *ROS∅, eff↑,
6203- Cuc,  immuno,    Isocucurbitacin B targets STAT3 to induce ferroptosis and promote anti-PD1 immunotherapy responses in breast cancer
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, BT549 - in-vivo, BC, 4T1
Ferroptosis↑, STAT3↓, GPx4↓, Imm↑, PD-L1↓, TumCG↓, ATP↓, OXPHOS↓,
6227- CUR,    Revisiting Curcumin in Cancer Therapy: Recent Insights into Molecular Mechanisms, Nanoformulations, and Synergistic Combinations
- Review, Var, NA
Wnt↓, β-catenin/ZEB1↓, PI3K↓, Akt↓, mTOR↓, JAK↓, STAT3↓, MAPK↓, NF-kB↓, NOTCH↓, TumCG↓, Apoptosis↑, GSK‐3β↓, cMyc↓, survivin↓, Axin2↑, TumCCA↑, PTEN↑, P53↑, ROS↑, Casp3↑, PARP↑, Ferroptosis↑, angioG↓, TumCI↓, TumMeta↓, BioAv↓, Half-Life↓, ChemoSen↑,
6223- CUR,    Curcumin Rewires the Tumor Metabolic Landscape: Mechanisms and Clinical Prospects
- Review, Var, NA
Ferroptosis↑, GutMicro↑, Akt↓, mTOR↓, NF-kB↓, Wnt↓, β-catenin/ZEB1↓, STAT3↓, TumCP↓, TumCI↓, TumMeta↓, AMPK↑, P53↑, NRF2↑, TumCCA↑, Apoptosis↑, Casp↑, GPx4↓, DNMTs↓, HDAC↓, VEGF↓, Imm↑, NK cell↑, Warburg↓, Hif1a↓, HK2↓, PKM2↓, LDHA↓, GLUT1↓, MCT1↓, AMPK↑, FASN↓, SCD1↓, GLS↓, Apoptosis↑, ETC↓, MMP↓, ROS↑, lipid-P↑, ChemoSen↑, PDK1↓, Beclin-1↓, ATP↓, Glycolysis↓, GlucoseCon↓, lactateProd↑, MMPs↓, GSH↓, G6PD↓, OXPHOS↓, SREBP2↓, COX2↓, AP-1↓, NADH↓, NRF2↑, HO-1↑, Iron↑, MDA↑, *ROS↓, *Inflam↓,
6210- CUR,    Potential Roles and Mechanisms of Curcumin and its Derivatives in the Regulation of Ferroptosis
Ferroptosis↑, *Ferroptosis↓, ROS↑, Fenton↑, *IronCh↑, GPx4↓, MDA↑, GSH↓, *NRF2↑, *HO-1↑,
404- CUR,    Curcumin induces ferroptosis in non-small-cell lung cancer via activating autophagy
- vitro+vivo, Lung, A549 - vitro+vivo, Lung, H1299
TumAuto↑, TumCG↓, TumCP↓, Iron↑, GSH↓, lipid-P↑, GPx↓, mtDam↑, autolysosome↑, Beclin-1↑, LC3s↑, p62↓, Ferroptosis↑,
414- CUR,    Transcriptome Investigation and In Vitro Verification of Curcumin-Induced HO-1 as a Feature of Ferroptosis in Breast Cancer Cells
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231
Ferroptosis↑, Iron↑, ROS↑, lipid-P↑, MDA↑, GSH↓, HO-1↑, NRF2↑, GPx↓, ROS↑, Iron↑, GPx4↓, HSP70/HSPA5↑, ATFs↑, CHOP/DDIT3↑, MDA↑, FTL↑, FTH1↑, BACH1↑, REL↑, USF1↑, NFE2L2↑,
6745- DHA,    Omega-3 fatty acid DHA induces ferroptosis in colorectal cancer patient-derived organoids and drug-tolerant cells
- in-vitro, CRC, HT29
tumCV↓, selectivity↑, Ferroptosis↑, lipid-P↑, mt-ROS↑, ChemoSen↑, *toxicity↓, TumCG↓, eff↑, eff↑, Dose↝, mtDam↑, *Inflam↓, *chemoP↑, Dose↑,
6746- DHA,    Free docosahexaenoic acid promotes ferroptotic cell death via lipoxygenase dependent and independent pathways in cancer cells
- vitro+vivo, Pca, PC3 - in-vitro, Pca, 22Rv1 - in-vitro, Pca, DU145 - in-vitro, Pca, LNCaP - in-vitro, Colon, HT29 - in-vitro, Cerv, HeLa
Ferroptosis↑, ROS↑, lipid-P↑,
6747- DHA,  erastin,    ELOVL5 Regulates Ferroptosis in Breast Cancer Cells
- in-vitro, BC, MDA-MB-231
Ferroptosis↑, eff↑,
5191- dietMet,    Intermittent dietary methionine deprivation facilitates tumoral ferroptosis and synergizes with checkpoint blockade
- in-vitro, Colon, HT29
ChemoSen↑, RadioS↑, Ferroptosis↑, eff↑, eff↑, GSH↓, eff↓,
4990- Dipy,    Characterization of dipyridamole as a novel ferroptosis inhibitor and its therapeutic potential in acute respiratory distress syndrome management
- in-vivo, Nor, NA
*Ferroptosis↓, *HO-1↓, SOD1↑,
5007- DSF,  Cu,    Nrf2/HO-1 Alleviates Disulfiram/Copper-Induced Ferroptosis in Oral Squamous Cell Carcinoma
- vitro+vivo, Oral, NA
AntiTum↑, TumCP↓, Ferroptosis↑, Iron↑, lipid-P↑, NRF2↓, HO-1↓,
5008- DSF,  Cu,    Overcoming the compensatory elevation of NRF2 renders hepatocellular carcinoma cells more vulnerable to disulfiram/copper-induced ferroptosis
- in-vitro, HCC, NA
selectivity↑, TumCD↑, TumCMig↓, TumCI↓, angioG↓, mtDam↑, Iron↑, lipid-P↑, Ferroptosis↑, NF-kB↑, p‑p62↑, Keap1↓, eff↑, eff↓, ChemoSen↑,
3215- EGCG,    Epigallocatechin gallate modulates ferroptosis through downregulation of tsRNA-13502 in non-small cell lung cancer
- in-vitro, NSCLC, A549 - in-vitro, NSCLC, H1299
TumCP↓, Ki-67↓, GPx4↓, ACSL4↑, Iron↑, MDA↑, ROS↑, Ferroptosis↑, eff↑, NRF2↑, HO-1↑,
5046- erastin,  SAS,    The structure of erastin-bound xCT–4F2hc complex reveals molecular mechanisms underlying erastin-induced ferroptosis
- Study, Var, NA
xCT↓, ROS↑, TumCG↓, GSH↓, Ferroptosis↑,
5047- erastin,    The ferroptosis inducer erastin irreversibly inhibits system xc− and synergizes with cisplatin to increase cisplatin’s cytotoxicity in cancer cells
- in-vitro, Ovarian, NA
xCT↓, GSH↓, Ferroptosis↑, ChemoSen↑, eff↑,
5048- erastin,    How erastin assassinates cells by ferroptosis revealed
- Review, Var, NA
Ferroptosis↑, xCT↓, lipid-P↑,
2204- erastin,    Regulation of ferroptotic cancer cell death by GPX4
- in-vitro, fibroS, HT1080
GSH↓, Ferroptosis↑, ROS↑, GPx↓, GPx4↓, lipid-P↑, eff↓, eff↑,
6862- FBZ,    Research: The Urgent Need for Clinical Studies to Evaluate the Anti-Tumor Efficacy of Fenbendazole
- Review, Var, NA
mitA↑, Apoptosis↑, GLUT4↓, HK2↓, Warburg↓, TumCCA↑, P53↑, Casp↑, TumCP↓, ROS↑, Ferroptosis↑, TumVol↓, Dose↝, BioAv↓, RadioS↝, ChemoSen↑,
6891- Fer,    Iron oxide nanoparticles inhibit tumor growth by ferroptosis in diffuse large B-cell lymphoma
- vitro+vivo, lymphoma, NA
TumCG↓, Ferroptosis↑, i-Iron↑, lipid-P↑, GPx4↓, ROS↑, Fenton↑, TfR1/CD71↝, FPN↝, LIP↑, TumCP↓, Apoptosis↑, TumCG↓,
6983- Form,    Formononetin enhances angiogenesis in diabetic wounds by inhibiting ferroptosis through suppression of mtROS-mediated xCT/GPX4 upregulation
- vitro+vivo, Nor, HUVECs - vitro+vivo, Diabetic, NA
*BloodF↑, *Ferroptosis↓, *eff↓, *mtDam↓, *xCT↑, *GPx4↑, *Wound Healing↑, *CD31↑, *mt-ROS↓,
6976- Form,    Study on the Mechanism of Formononetin Against Hepatocellular Carcinoma: Regulating Metabolic Pathways of Ferroptosis and Cell Cycle
- vitro+vivo, HCC, HepG2
ROS↑, DNAdam↑, TumCCA↑, CHK1↝, CDC25↝, CDK1↝, CycB/CCNB1↝, GSH↓, lipid-P↑, Ferroptosis↑, xCT↓, P53↓, GPx4↓, other↝, TumCP↓, γH2AX↑, TumCG↓, Ki-67↓, PCNA↓, MMP↓,
7046- GA,    Gallic acid: A promising anti-non-small cell lung cancer compound targeting early growth response protein-1 for apoptosis and ferroptosis
- in-vitro, NSCLC, A549 - in-vitro, NSCLC, H1299
TumCP↓, TumCCA↑, TumCMig↓, TumCI↓, Apoptosis↑, Ferroptosis↑, THBS1↓, EGR1↓, TGF-β1↓, SMAD2↓, SMAD3↓, GPx4↓, ROS↑, i-MDA↑, i-Iron↑,
1955- GamB,    Gambogic acid inhibits thioredoxin activity and induces ROS-mediated cell death in castration-resistant prostate cancer
- in-vitro, Pca, PC3 - in-vitro, Pca, LNCaP - in-vitro, Pca, DU145
ROS↑, Apoptosis↑, Ferroptosis↑, Trx↓, eff↑, TrxR↓, Dose∅, MMP↓, eff↑, Casp↑, NADPH↓, TrxR↓, ChemoSen↑, AR↓,
7066- GamB,    Unravelling the Therapeutic Potential of Gambogic Acid: Deciphering Its Molecular Mechanism of Action and Emerging Role as an Anticancer Xanthone
- Review, Var, NA
angioG↓, TumMeta↓, ChemoSen↑, *cardioP↑, *Inflam↓, *AntiViral↑, *antiOx↑, NF-kB↓, TNF-α↓, COX2↓, iNOS↓, Apoptosis↑, TumAuto↑, TumCP↓, TumCI↓, BioAv↓, ROS↑, MMP↓, SIRT1↓, Akt↓, mTORC1↓, AMPK↑, LRIG1↑, ER Stress↑, Paraptosis↑, Ferroptosis↑, HSP90↓, GSH↓, lipid-P↑, GPx4↓, miR-21↓, PI3K↓, Akt↓, PTEN↑, ASAP2↓, CDK7↓,
7215- GBE,  Cisplatin,    Ginkgetin derived from Ginkgo biloba leaves enhances the therapeutic effect of cisplatin via ferroptosis-mediated disruption of the Nrf2/HO-1 axis in EGFR wild-type non-small-cell lung cancer
- vitro+vivo, NSCLC, NA
AntiCan↑, TumAuto↑, ChemoSen↑, Iron↑, lipid-P↑, Ferroptosis↑, xCT↓, GPx4↓, GSH/GSSG↓, ROS↑, NRF2↓, HO-1↓, MMP↓,
7211- GBE,    Ginkgo Biflavones Cause p53 Wild-Type Dependent Cell Death in a Transcription-Independent Manner of p53
- in-vitro, CRC, HCT116
P53↑, MDM2↓, TumCD↓, tumCV↓, Apoptosis↑, TumCCA↑, ROS↑, Ferroptosis↑, ChemoSen↑,
7242- Gink,  Cisplatin,    Ginkgetin reverses cisplatin resistance in cervical cancer by regulating the Nrf2/HO-1 signaling pathway to induce ferroptosis
- in-vitro, Cerv, HeLa
TumCP↓, NRF2↓, ROS↑, i-Iron↑, GSH↓, SOD↓, Catalase↓, lipid-P↑, ACSL4↑, NO↓, GPx4↓, Ferroptosis↑,
7250- Gink,    Ginkgetin from Ginkgo biloba: mechanistic insights into anticancer efficacy
- Review, Var, NA
AntiCan↑, toxicity↓, ChemoSen↑, chemoP↑, TumCCA↑, TumCD↑, TumCI↓, angioG↓, Ferroptosis↑, Imm↑, MOMP↑, Cyt‑c↑, Casp↑, cl‑Casp3↑, cl‑Casp9↑, cl‑PARP↑, Apoptosis↑, ROS↑, TumAuto↑, GPx4↓, xCT↓, RadioS↑, NRF2↓, HO-1↓, HSP90↓, Dose↝, Dose↝, BioAv↓, BioAv↝, CYP3A4↓, *toxicity↑, *toxicity↝,
3761- H2,    Therapeutic Inhalation of Hydrogen Gas for Alzheimer's Disease Patients and Subsequent Long-Term Follow-Up as a Disease-Modifying Treatment: An Open Label Pilot Study
- Human, AD, NA
*cognitive↑, *BBB↑, *ROS↓, *NRF2↑, *Inflam↓, *NFAT↓, *FAO↓, *4-HNE↓, *PGC-1α↑, *Ferroptosis↓,
2082- HNK,    Revealing the role of honokiol in human glioma cells by RNA-seq analysis
- in-vitro, GBM, U87MG - in-vitro, GBM, U251
AntiCan↑, TumCP↑, TumAuto↑, Apoptosis↑, *BioAv↑, *neuroP↑, *NF-kB↑, MAPK↑, GPx4↑, Tf↑, BAX↑, Bcl-2↓, antiOx↑, Hif1a↓, Ferroptosis↑,
2081- HNK,    Honokiol induces ferroptosis in colon cancer cells by regulating GPX4 activity
- in-vitro, Colon, RKO - in-vitro, Colon, HCT116 - in-vitro, Colon, SW48 - in-vitro, Colon, HT-29 - in-vitro, Colon, LS174T - in-vitro, Colon, HCT8 - in-vitro, Colon, SW480 - in-vivo, NA, NA
tumCV↓, ROS↑, Iron↑, GPx4↓, mtDam↑, Ferroptosis↑, TumVol↓, TumW↓,
2080- HNK,    Honokiol Induces Ferroptosis by Upregulating HMOX1 in Acute Myeloid Leukemia Cells
- in-vitro, AML, THP1 - in-vitro, AML, U937 - in-vitro, AML, SK-HEP-1
tumCV↓, TumCCA↑, Ferroptosis↑, lipid-P↑, HO-1↑, GPx4∅,
4641- HT,    Hydroxytyrosol induced ferroptosis through Nrf2 signaling pathway in colorectal cancer cells
- in-vitro, CRC, HCT116 - in-vitro, CRC, SW48
Ferroptosis↑, Iron↑, lipid-P↑, ROS↑, GSH↓, MMP↓, GPx4↓, TLR1↑, eff↓, NRF2↓, ROS↑,
1921- JG,    Juglone induces ferroptotic effect on hepatocellular carcinoma and pan-cancer via the FOSL1-HMOX1 axis
- in-vitro, PC, NA - vitro+vivo, PC, NA
TumCG↓, Ferroptosis↑, ROS↑, Iron↑, lipid-P↑, MDA↑, GSH↓, FOSL1↑, HO-1↑,
5099- JG,    Juglone induces ferroptosis in glioblastoma cells by inhibiting the Nrf2-GPX4 axis through the phosphorylation of p38MAPK
- vitro+vivo, GBM, LN229 - vitro+vivo, GBM, T98G
Ferroptosis↑, p‑MAPK↑, NRF2↓, GPx4↓, TumPF↓, Apoptosis↑, ROS↑, GSH↓, lipid-P↑, Ki-67↓, TumCG↓,
1275- LT,    Mechanism of luteolin induces ferroptosis in nasopharyngeal carcinoma cells
- in-vitro, Laryn, NA
Ferroptosis↑, MDA↑, Iron↑, SOD↓, GSH↓, GPx4↓, SOX4↓, GDF15↓,
582- MF,  immuno,  VitC,    Magnetic field boosted ferroptosis-like cell death and responsive MRI using hybrid vesicles for cancer immunotherapy
- in-vitro, Pca, TRAMP-C1 - in-vivo, NA, NA
Fenton↑, Ferroptosis↑, ROS↑, TumCG↓, Iron↑, GPx4↓,
1273- Myr,    Myricetin Induces Ferroptosis and Inhibits Gastric Cancer Progression by Targeting NOX4
- vitro+vivo, GC, NA
Ferroptosis↑, MDA↑, Iron↑, GSH↓, NOX4↑, NRF2↓, GPx4↓,
2937- NAD,    High-Dosage NMN Promotes Ferroptosis to Suppress Lung Adenocarcinoma Growth through the NAM-Mediated SIRT1-AMPK-ACC Pathway
- in-vitro, Lung, A549
SIRT1↑, Dose↝, TumCP⇅, Ferroptosis↑, lipid-P↑, AMPK↑, ACC↑,
1225- OLST,    Orlistat Induces Ferroptosis in Pancreatic Neuroendocrine Tumors by Inactivating the MAPK Pathway
- vitro+vivo, PC, NA
TumCMig↓, TumCI↓, Ferroptosis↑, MAPK↓,
2054- PB,    Sodium butyrate induces ferroptosis in endometrial cancer cells via the RBM3/SLC7A11 axis
- in-vitro, EC, ISH - in-vitro, EC, HEC1B
Ferroptosis↑, xCT↓, RBM3↑, HDAC↓, ROS↑,
4925- PEITC,    PEITC triggers multiple forms of cell death by GSH-iron-ROS regulation in K7M2 murine osteosarcoma cells
- in-vitro, OS, NA
tumCV↓, TumCP↓, TumCCA↑, GSH↓, ROS↑, Ferroptosis↑, Apoptosis↑, TumAuto↑, MAPK↑, TumCG↓, Dose⇅,
4927- PEITC,    Targeting ferroptosis in osteosarcoma
- Review, OS, NA
AntiCan↑, BioAv↑, Ferroptosis↑, TfR1/CD71↑, Iron↑, ROS↑, MDA↑, lipid-P↑, GPx4↓,

Showing Research Papers: 51 to 100 of 140
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 140

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

ASAP2↓, 1,   CDK7↓, 1,   FPN↝, 1,   LIP↑, 1,   LRIG1↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 1,   Catalase↓, 1,   Fenton↑, 4,   Ferroptosis↑, 47,   GPx↓, 3,   GPx4↓, 21,   GPx4↑, 1,   GPx4∅, 1,   GSH↓, 18,   GSH/GSSG↓, 2,   HO-1↓, 3,   HO-1↑, 5,   Iron↑, 15,   i-Iron↑, 3,   Keap1↓, 1,   lipid-P↑, 22,   MDA↑, 9,   i-MDA↑, 1,   NADH↓, 1,   NFE2L2↑, 1,   NOX4↑, 1,   NRF2↓, 7,   NRF2↑, 5,   OXPHOS↓, 2,   ROS↑, 32,   mt-ROS↑, 1,   SOD↓, 2,   SOD1↑, 1,   Trx↓, 1,   TrxR↓, 2,   xCT↓, 7,  

Metal & Cofactor Biology(tgid=2) ⓘ

FTH1↑, 1,   FTL↑, 1,   Tf↑, 1,   TfR1/CD71↑, 1,   TfR1/CD71↝, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↓, 4,   CDC25↝, 1,   ETC↓, 2,   MMP↓, 7,   MPT↑, 1,   mtDam↑, 4,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACC↑, 1,   ACSL4↑, 2,   AMPK↑, 4,   cMyc↓, 1,   CYP3A4↓, 1,   FASN↓, 1,   G6PD↓, 1,   GLS↓, 1,   GlucoseCon↓, 1,   Glycolysis↓, 1,   HK2↓, 2,   lactateProd↑, 1,   LDHA↓, 1,   MCU↓, 1,   NADPH↓, 1,   PDK1↓, 1,   PKM2↓, 1,   SCD1↓, 1,   SIRT1↓, 1,   SIRT1↑, 1,   SREBP2↓, 1,   Warburg↓, 2,  

Cell Death(tgid=5) ⓘ

Akt↓, 5,   Apoptosis↓, 1,   Apoptosis↑, 14,   BAX↑, 1,   Bcl-2↓, 2,   Casp↑, 5,   Casp3↑, 2,   cl‑Casp3↑, 1,   Casp9↑, 1,   cl‑Casp9↑, 1,   Cupro↑, 1,   Cyt‑c↑, 2,   Ferroptosis↑, 47,   iNOS↓, 1,   MAPK↓, 2,   MAPK↑, 2,   p‑MAPK↑, 1,   Mcl-1↓, 1,   MCT1↓, 1,   MDM2↓, 1,   MOMP↑, 1,   Paraptosis↑, 1,   survivin↓, 2,   TumCD↓, 1,   TumCD↑, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

miR-21↓, 1,   other↑, 2,   other↝, 2,   tumCV↓, 5,   USF1↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATFs↑, 1,   CHOP/DDIT3↑, 1,   ER Stress↑, 2,   HSP70/HSPA5↑, 1,   HSP90↓, 2,  

Autophagy & Lysosomes(tgid=9) ⓘ

autolysosome↑, 1,   Beclin-1↓, 1,   Beclin-1↑, 1,   LC3s↑, 1,   p62↓, 1,   p‑p62↑, 1,   TumAuto↑, 6,  

DNA Damage & Repair(tgid=10) ⓘ

CHK1↝, 1,   DNAdam↑, 1,   DNMTs↓, 1,   P53↓, 1,   P53↑, 5,   PARP↑, 1,   cl‑PARP↑, 1,   PCNA↓, 1,   γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↝, 1,   CycB/CCNB1↝, 1,   mitA↑, 1,   TumCCA↑, 10,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Axin2↑, 1,   EMT↓, 1,   FOSL1↑, 1,   GDF15↓, 1,   GSK‐3β↓, 1,   HDAC↓, 2,   mTOR↓, 3,   mTORC1↓, 1,   NOTCH↓, 1,   PI3K↓, 2,   PTEN↑, 2,   STAT3↓, 3,   TumCG↓, 13,   Wnt↓, 2,  

Migration(tgid=13) ⓘ

Akt2↓, 1,   AP-1↓, 1,   BACH1↑, 1,   Ca+2↓, 1,   Ca+2↑, 1,   Ki-67↓, 3,   MMPs↓, 1,   SMAD2↓, 1,   SMAD3↓, 1,   SOX4↓, 1,   TGF-β1↓, 1,   THBS1↓, 1,   TumCI↓, 8,   TumCI↑, 1,   TumCMig↓, 4,   TumCMig↑, 1,   TumCP↓, 12,   TumCP↑, 2,   TumCP⇅, 1,   TumMeta↓, 4,   TumMeta↑, 1,   TumPF↓, 1,   β-catenin/ZEB1↓, 2,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 4,   angioG↑, 1,   ECM/TCF↓, 1,   EGR1↓, 1,   Hif1a↓, 4,   NO↓, 1,   REL↑, 1,   VEGF↓, 1,  

Barriers & Transport(tgid=15) ⓘ

GLUT1↓, 1,   GLUT4↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2↓, 2,   Imm↑, 3,   JAK↓, 1,   NF-kB↓, 3,   NF-kB↑, 1,   NK cell↑, 1,   PD-L1↓, 1,   TLR1↑, 1,   TNF-α↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 4,   BioAv↑, 1,   BioAv↝, 1,   ChemoSen↑, 13,   DDS↑, 1,   Dose↑, 1,   Dose⇅, 1,   Dose↝, 5,   Dose∅, 1,   eff↓, 4,   eff↑, 15,   Half-Life↓, 1,   RadioS↑, 2,   RadioS↝, 1,   selectivity↑, 3,  

Clinical Biomarkers(tgid=22) ⓘ

AR↓, 1,   GutMicro↑, 1,   Ki-67↓, 3,   PD-L1↓, 1,   RBM3↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 4,   AntiTum↑, 2,   chemoP↑, 1,   Risk↓, 1,   toxicity↓, 1,   TumVol↓, 2,   TumW↓, 1,  
Total Targets: 209

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↓, 1,   antiOx↑, 2,   Ferroptosis↓, 4,   GPx4↑, 1,   HO-1↓, 1,   HO-1↑, 1,   NRF2↑, 2,   ROS↓, 2,   ROS∅, 1,   mt-ROS↓, 1,   xCT↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

mtDam↓, 1,   PGC-1α↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

FAO↓, 1,  

Cell Death(tgid=5) ⓘ

Ferroptosis↓, 4,  

Migration(tgid=13) ⓘ

CD31↑, 1,   NFAT↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Inflam↓, 4,   NF-kB↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 1,   eff↓, 1,  

Clinical Biomarkers(tgid=22) ⓘ

BloodF↑, 1,  

Functional Outcomes(tgid=23) ⓘ

cardioP↑, 1,   chemoP↑, 1,   cognitive↑, 1,   neuroP↑, 1,   toxicity↓, 1,   toxicity↑, 1,   toxicity↝, 1,   Wound Healing↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiViral↑, 1,  
Total Targets: 33

Scientific Paper Hit Count for: Ferroptosis, Ferroptosis
19 Artemisinin
8 Shikonin
7 erastin
7 Curcumin
7 Selenite (Sodium)
4 Ashwagandha(Withaferin A)
4 Baicalein
4 Cisplatin
4 Copper and Cu NanoParticles
4 Sulfasalazine
3 Boron
3 immunotherapy
3 Docosahexaenoic Acid
3 Honokiol
3 Piperlongumine
3 Rosmarinic acid
3 salinomycin
2 Andrographis
2 Luteolin
2 Berberine
2 Betulinic acid
2 brusatol
2 Chlorogenic acid
2 Citric Acid
2 Coenzyme Q10
2 Disulfiram
2 Formononetin
2 Gambogic Acid
2 Ginkgo biloba
2 Ginkgetin
2 Juglone
2 Vitamin C (Ascorbic Acid)
2 Phenethyl isothiocyanate
2 Sulforaphane (mainly Broccoli)
1 3-bromopyruvate
1 cetuximab
1 Astragalus
1 Silver-NanoParticles
1 Allicin (mainly Garlic)
1 5-fluorouracil
1 Docetaxel
1 doxorubicin
1 Astaxanthin
1 Radiotherapy/Radiation
1 Atorvastatin
1 Ras-selective lethal 3
1 Boswellia (frankincense)
1 Carvacrol
1 Celastrol
1 Vitamin K2
1 Crocetin
1 Cucurbitacin
1 diet Methionine-Restricted Diet
1 Dipyridamole
1 EGCG (Epigallocatechin Gallate)
1 Fenbendazole
1 ferumoxytol
1 Gallic acid
1 Hydrogen Gas
1 HydroxyTyrosol
1 Magnetic Fields
1 Myricetin
1 nicotinamide adenine dinucleotide
1 Orlistat
1 Phenylbutyrate
1 Psoralidin
1 Quercetin
1 Resveratrol
1 Selenium
1 Silymarin (Milk Thistle) silibinin
1 Salvia miltiorrhiza
1 Spermidine
1 Osimertinib
1 Adagrasib
1 Aflavin-3,3′-digallate
1 Urolithin
1 Zinc
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:114  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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