GSTs Cancer Research Results

GSTs, Glutathione S-transferases: Click to Expand ⟱
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Type:
Glutathione S-transferases (GSTs) are a family of phase II detoxification enzymes that play key roles in catalyzing the conjugation of glutathione (GSH) to a wide range of electrophilic compounds. This family includes multiple isoenzymes (e.g., GST-α, GST-μ, GST-π) with tissue-specific expression patterns and overlapping as well as distinct substrate specificities.

-GSTs are important for detoxifying potentially harmful compounds, including products of oxidative stress, environmental toxins, and chemotherapeutic agents.
-They contribute to the cellular defense mechanism against oxidative damage and help maintain cellular redox balance.
-Beyond detoxification, GSTs can modulate cell signaling pathways, potentially affecting cell proliferation, apoptosis, and drug resistance.

-GST-π is commonly upregulated in several cancers such as breast, lung, colorectal, and hematologic malignancies.
-Elevated expression of specific GST isoenzymes—most notably GST-π—has been associated with a poorer prognosis in several cancer types. This is often linked to resistance to chemo- or radiotherapy, as higher GST activity can lead to more efficient detoxification of these agents, reducing their cytotoxic effects.
-In contrast, reduced GST expression in some contexts might indicate a less robust detoxification system, which can correlate with increased sensitivity to oxidative stress and possibly a less aggressive tumor phenotype.
Scientific Papers found: Click to Expand⟱
3528- Lyco,    The Importance of Antioxidant Activity for the Health-Promoting Effect of Lycopene
- Review, Nor, NA - Review, AD, NA - Review, Park, NA
*antiOx↑, *ROS↓, *BioAv↝, *Half-Life↑, *BioAv↓, *BioAv↑, *cardioP↑, *neuroP↑, *H2O2↓, *VitC↑, *VitE↑, *GPx↑, *GSH↑, *MPO↓, *GSTs↓, *SOD↑, *NF-kB↓, *IL1β↓, *IL6↓, *IL10↑, *MAPK↓, *Akt↓, *COX2/PTGS2↓, *TNF-α↓, *TGF-β1↑, *NO↓, *GSR↑, *NRF2↑, *HO-1↑, *TAC↑, *Inflam↓, *BBB↑, *neuroP↑, *memory↑,
3264- Lyco,    Pharmacological potentials of lycopene against aging and aging‐related disorders: A review
- Review, Var, NA - Review, AD, NA - Review, Stroke, NA
*antiOx↑, *ROS↓, *SOD↑, *Catalase↑, *GSH↑, *GSTs↑, *MDA↓, *lipid-P↓, *NRF2↑, *HO-1↑, *iNOS↓, *NO↓, *TAC↑, *NOX4↓, *Inflam↓, *IL1↓, *IL6↓, *IL8↓, *IL1β↓, *TNF-α↓, *TLR2↓, *TLR4↓, *VCAM-1↓, *ICAM-1↓, *STAT3↓, *NF-kB↓, *ERK↓, *BP↓, ROS↓, PGE2↓, cardioP↑, *neuroP↑, *creat↓, *RenoP↑, *CRM↑,
8414- Lyco,    Exploring the Therapeutic Potential of Lycopene: Mechanisms, Biological Activities, and Health Benefits
- Review, Var, NA - Review, AD, NA
*ROS↓, *Inflam↓, *hepatoP↑, *cardioP↑, *neuroP↑, *AntiArt↑, *Obesity↓, *Wound Healing↑, *BioAv↑, *GSTs↑, *Trx1↑, *SOD↑, *Catalase↑, *ALAT↓, *LDH↓, *AST↓, *MDA↓, *cognitive↑, *memory↑, *NeuroI↓, *Aβ↓, *LRP1↑, *RAGE↓, *NRF2↑, *HO-1↑, tumCV?, Bax:Bcl2↑, DNAdam↑, Apoptosis↑, β-catenin/ZEB1↓, cMyc↓, cycD1/CCND1↓, ROS↓, TumCCA↑, Akt↓, *Synergy↑, *MDA↓, *NF-kB↓, *TGF-β↓, *Casp3↓, *Catalase↑, *GSH↑, *Bcl-2↑, *IL10↑, *MUC1↑, *IBI↑, *RenoP↑, *ChemoSen↑, *Synergy↑, *Synergy↑, *BMD↑,
4797- Lyco,    A mechanistic updated overview on lycopene as potential anticancer agent
- Review, Var, NA
AntiCan↑, antiOx↓, Apoptosis↑, TumCP↓, TumCCA↑, Risk↓, ROS↓, SOD↑, Catalase↑, GSTs↑, ARE↑, NRF2↑, cycD1/CCND1↓, cycE/CCNE↑, CDK2↑, p27/CDKN1B↑, BAX↑, Bcl-2↓, P53↑, ChemoSen↑,
4794- Lyco,    Anticancer Effect of Lycopene in Gastric Carcinogenesis
- Review, GC, NA
*AntiCan↑, *ROS↓, *GSH↑, *GPx↑, *GSTs↑, TumCG↓, Apoptosis↑, ERK↓, Bcl-2↓, BAX↑, Cyt‑c↑, TumCCA↑, *DNAdam↓,
3844- MO,    Review of the Safety and Efficacy of Moringa oleifera
- Review, Nor, NA
*antiOx↑, *RenoP↑, *hepatoP↑, *radioP↑, *eff↑, *toxicity↓, *ROS↓, *lipid-P↓, *DNAdam↓, *Catalase↑, *SOD↑, *GPx↑, *GSR↑, *GSTs↑, *AST↓, *ALAT↓, *ALP↓, *Bil↓,
8909- MO,    Effect of Moringa oleifera on inflammatory diseases: an umbrella review of 26 systematic reviews
- Review, Nor, NA
*Ingr↝, *LDL↓, *TG/TAG↓, *TC↓, *HDL↑, *VLDL↓, *ROS↓, *TAC↑, *HK2↑, *Glycolysis↑, *GLUT4↑, Apoptosis↑, P53↑, ROS↑, NF-kB↓, TumCP↓, TumCCA↑, COX2/PTGS2↓, NO↓, MAP2K1/MEK1↓, *GSTs↑, *NQO1↑, *NRF2↑, *ARE↑,
3595- PI,    Black pepper and health claims: a comprehensive treatise
- Review, Var, NA - Review, AD, NA
*antiOx↑, *ROS↓, *chemoP↑, TumCG↓, *cognitive↑, *MMPs↓, *PGE2↓, *AP-1↓, *5LO↓, *COX1↓, *other↑, *other↑, *other↑, *SOD↑, *Catalase↑, *GSTs↑, *GSR↑, *other↑, *Weight↓, *BioEnh↑, *BioAv↑, *Synergy↑, *CYP3A2↓, *neuroP↑, *BP↓, *other↑,
3596- PI,    Antioxidant efficacy of black pepper (Piper nigrum L.) and piperine in rats with high fat diet induced oxidative stress
- in-vivo, Nor, NA
*TBARS↑, *SOD↑, *Catalase↑, *GSTs↑, *GPx↑, *GSH↑, *ROS↓,
2942- PL,    Piperlongumine increases sensitivity of colorectal cancer cells to radiation: Involvement of ROS production via dual inhibition of glutathione and thioredoxin systems
- in-vitro, CRC, CT26 - in-vitro, CRC, DLD1 - in-vivo, CRC, CT26
ROS↑, GSH↓, TrxR↓, RadioS↑, DNAdam↑, TumCCA↑, mitResp↓, GSTs↓, OS↑,
3079- RES,    Therapeutic role of resveratrol against hepatocellular carcinoma: A review on its molecular mechanisms of action
- Review, Var, NA
angioG↓, TumMeta↓, ChemoSen↑, NADPH↑, SIRT1↑, NF-kB↓, NLRP3↓, Dose↝, COX2/PTGS2↓, MMP9↓, PGE2↓, TIMP1↑, TIMP2↑, Sp1/3/4↓, p‑JNK↓, uPAR↓, ROS↓, CXCR4↓, IL6↓, Gli1↓, *ROS↓, *GSTs↑, *SOD↑, *Catalase↑, *GPx↑, *lipid-P↓, *GSH↑, Synergy↑, Synergy↑, Synergy↑,
3001- RosA,    Therapeutic Potential of Rosmarinic Acid: A Comprehensive Review
- Review, Var, NA
TumCP↓, Apoptosis↑, TumMeta↓, Inflam↓, *antiOx↑, *AntiAge↑, *ROS↓, BioAv↑, Dose↝, NRF2↑, P-gp/ABCB1↑, ATP↑, MMPs↓, cl‑PARP↓, Hif1a↓, GlucoseCon↓, lactateProd↓, Warburg↓, TNF-α↓, COX2/PTGS2↓, IL6↓, HDAC2↓, GSH↑, ROS↓, ChemoSen↑, *BG↓, *IL1β↓, *TNF-α↓, *IL6↓, *p‑JNK↓, *p38↓, *Catalase↑, *SOD↑, *GSTs↑, *VitC↑, *VitE↑, *GSH↑, *GutMicro↑, *cardioP↑, *ROS↓, *MMP↓, *lipid-P↓, *NRF2↑, *hepatoP↑, *neuroP↑, *P450↑, *HO-1↑, *AntiAge↑, *motorD↓,
6442- SAO,    Medicinal properties of alpha-santalol, a naturally occurring constituent of sandalwood oil: review
- Review, RCC, NA
AntiTum↑, Apoptosis↑, TumCCA↑, *Inflam↓, selectivity↑, tumCV↓, Casp8↓, Casp9↓, Casp6↓, Casp3↓, cl‑PARP↑, angioG↓, VEGFR2/KDR/Flk1↓, Akt↑, mTOR↓, TumCG↓, *GSTs↑, *antiOx↑, *ROS↓,
4735- SeNPs,    Selenium triggers Nrf2-AMPK crosstalk to alleviate cadmium-induced autophagy in rabbit cerebrum
- in-vivo, Nor, NA
*MDA↓, *H2O2↓, *Catalase↑, *SOD↑, *GSTs↑, *GSH↑, *NRF2↓, *ATG3↓, *AMPK↓, *ROS↓,
4190- Sesame,    Sesame Seeds: A Nutrient-Rich Superfood
- Review, Nor, NA
*antiOx↑, *LDL↓, *Aβ↓, *TNF-α↓, *SOD↑, *SIRT1↑, *Catalase↑, *GSH↑, *MDA↓, *GSTs↑, *IL4↑, *GPx↑, *COX2/PTGS2↓, *PGE2↓, *NO↓, CDK2↑, COX2/PTGS2↑, MMP9↑, ICAM-1↓, *BDNF↑, *PPARγ↑, *AChE↓, *Inflam↓, *HO-1↑, *NF-kB↓, *ROS↓,
4199- SFN,    Sulforaphane and Brain Health: From Pathways of Action to Effects on Specific Disorders
- Review, AD, NA - Review, Park, NA
*BBB↑, *BDNF↑, *neuroG↑, *NRF2↑, *HO-1↑, *Catalase↑, *SOD↑, *HSPs↑, *GSTs↑, *Trx↑, *GPx↑, *GSR↑, *GSH↑, *NQO1↑, *GutMicro↑, *Inflam↓, *neuroP↑,
1726- SFN,    Sulforaphane: A Broccoli Bioactive Phytocompound with Cancer Preventive Potential
- Review, Var, NA
Dose↝, eff↝, IL1β↓, IL6↓, IL12↓, TNF-α↓, COX2/PTGS2↓, CXCR4↓, MPO↓, HSP70/HSPA5↓, HSP90↓, VCAM-1↓, IKKα↓, NF-kB↓, HO-1↑, Casp3↑, Casp7↑, Casp8↑, Casp9↑, cl‑PARP↑, Cyt‑c↑, Diablo↑, CHOP/DDIT3↑, survivin↓, XIAP↓, p38↑, Fas↑, PUMA↑, VEGF↓, Hif1a↓, Twist↓, Zeb1↓, Vim↓, MMP2↓, MMP9↓, E-cadherin↑, N-cadherin↓, Snail↓, CD44↓, cycD1/CCND1↓, cycA1/CCNA1↓, CycB/CCNB1↓, cycE/CCNE↓, CDK4↓, CDK6↓, p50↓, P53↑, P21↑, GSH↑, SOD↑, GSTs↑, mTOR↓, Akt↓, PI3K↓, β-catenin/ZEB1↓, IGF-1↓, cMyc↓, CSCs↓,
3313- SIL,    Silymarin attenuates post-weaning bisphenol A-induced renal injury by suppressing ferroptosis and amyloidosis through Kim-1/Nrf2/HO-1 signaling modulation in male Wistar rats
- in-vivo, Nor, NA
*NRF2↑, *HO-1↑, *creat↓, *BUN↓, *RenoP↑, *MDA↓, *TNF-α↓, *IL1β↓, *Cyt‑c↓, *Casp3↓, *GSTs↓, *GSH↑, *GPx4↑, *SOD↑, *GSR↓, *Ferroptosis↓,
3300- SIL,    Toward the definition of the mechanism of action of silymarin: activities related to cellular protection from toxic damage induced by chemotherapy
- Review, Var, NA
*ROS↓, *SOD↑, *hepatoP↑, *AST↓, *ALAT↓, *lipid-P↓, *GSH↑, *Catalase↑, *GSTs↑, *GSR↑, *TNF-α↓, *IFN-γ↓, *IL4↓, *IL2↓, *NF-kB↓, *IL10↑, *Inflam↓, COX2/PTGS2↓, Apoptosis↑, ChemoSen↑, PGE2↓, VEGF↓,
3293- SIL,    Silymarin (milk thistle extract) as a therapeutic agent in gastrointestinal cancer
- Review, Var, NA
hepatoP↑, TumMeta↓, Inflam↓, chemoP↑, radioP↑, Half-Life↝, *GSTs↑, p‑JNK↑, BAX↑, p‑p38↑, cl‑PARP↑, Bcl-2↓, p‑ERK↓, TumVol↓, Synergy↑, TumCCA↑, STAT3↓, Mcl-1↓, survivin↓, Bcl-xL↓, Casp3↑, Casp9↑, eff↑, CXCR4↓, Dose↝,
2088- TQ,    Nigella sativa L. and Its Bioactive Constituents as Hepatoprotectant: A Review
- Review, Nor, NA
*hepatoP↑, *lipid-P↓, *Thiols↑, *ROS↓, *Catalase↑, *SOD↑, *GSTs↑, *NF-kB↓, *COX2/PTGS2↓, *LOX1↓,
3407- TQ,    Thymoquinone and its pharmacological perspective: A review
- Review, Var, NA
*antiOx↑, *ROS↓, *GSTs↑, *GSR↑, *GSH↑, *RenoP↑, *IL1β↓, *TNF-α↓, *MMP13↓, *COX2/PTGS2↓, *PGE2↓, *radioP↑, Twist↓, EMT↓, NF-kB↓, p‑PI3K↓, p‑Akt↓, p‑GSK‐3β↓, DNMT1↓, HDAC↓,
3571- TQ,    The Role of Thymoquinone in Inflammatory Response in Chronic Diseases
- Review, Var, NA - Review, Stroke, NA
*BioAv↓, *BioAv↑, *Inflam↓, *antiOx↑, *ROS↓, *GSH↑, *GSTs↑, *MPO↓, *NF-kB↓, *COX2/PTGS2↓, *IL1β↓, *TNF-α↓, *IFN-γ↓, *IL6↓, *cardioP↑, *lipid-P↓, *TAC↑, *RenoP↑, Apoptosis↑, TumCCA↑, TumCP↓, TumCMig↓, angioG↓, TNF-α↓, NF-kB↓, ROS↑, EMT↓, *Aβ↓, *p‑tau↓, *BACE/β-secretase↓, *TLR2↓, *TLR4↓, *MyD88↓, *IRF3↓, *eff↑, Synergy↑, DNAdam↑, *iNOS↓,
5024- TQ,    Thymoquinone: A Tie-Breaker in SARS-CoV2-Infected Cancer Patients?
- Review, Covid, NA
*NRF2↑, *NF-kB↓, *Inflam↓, *ROS↓, *HO-1↑, antiOx↑, GSH↑, GSTs↑, GSR↑, SOD1↑, Catalase↑, GPx↑, p62↓, Beclin-1/ATG6↑, Sepsis↓, cardioP↑, hepatoP↑, neuroP↑,
5904- TV,    Pharmacological Properties and Molecular Mechanisms of Thymol: Prospects for Its Therapeutic Potential and Pharmaceutical Development
- Review, Var, NA - Review, Stroke, NA - Review, Diabetic, NA - Review, Obesity, NA - Review, AD, NA - Review, Arthritis, NA
*antiOx↑, *ROS↓, *Inflam↓, *Bacteria↓, AntiTum↑, IronCh↑, *HDL↑, *LDL↓, *BioAv↝, *Half-Life↝, *BioAv↑, *SOD↑, *GPx↑, *GSTs↑, *eff↑, radioP↑, *MDA↓, *other↑, *COX1↓, *COX2/PTGS2↓, *AntiAg↑, *RNS↓, *NO↓, *H2O2↓, *NOS2↓, *NADH↓, *Imm↑, Apoptosis↑, TumCP↓, angioG↓, TumCMig↓, Ca+2↑, TumCCA↑, DNAdam↑, BAX↑, Casp9↑, Casp8↑, Casp3↑, cl‑PARP↑, AIF↑, i-ROS↑, MMP↓, Cyt‑c↑, APAF1↑, Ca+2↑, MMP9↓, MMP2↓, PKCδ↓, ERK↓, H2O2↑, BAX↑, Bcl-2↓, DNAdam↑, lipid-P↑, ChemoSen↑, chemoP↑, *cardioP↑, *SOD↑, *Catalase↑, *GPx↑, *GSH↑, *BP↓, *AntiDiabetic↑, *Obesity↓, RenoP↑, *GastroP↑, hepatoP↑, *AChE↓, *cognitive↑, *BChE↓, *other↓, *BioAv↑,
2411- UA,    Ursolic acid in health and disease
- Review, Var, NA
Inflam↓, antiOx↑, NF-kB↓, Bcl-xL↓, Bcl-2↓, cycD1/CCND1↓, Ki-67↓, CD31/PECAM-1↓, STAT3↓, EGFR↓, P53↑, P21↓, HK2↓, PKM2↓, ATP↓, lactateProd↓, p‑ERK↓, MMP↓, NO↑, ATM↑, Casp3↑, AMPK↑, JNK↑, FAO↑, FASN↓, *GSH↑, *SOD↑, *Catalase↑, *GPx↑, *GSTs↑, neuroP↑,
7887- VT,  IVT,    Dietary Flavonoids Vitexin and Isovitexin: New Insights into Their Functional Roles in Human Health and Disease Prevention
- Review, AD, NA - Review, Var, NA
*antiOx↑, *Inflam↓, *AntiCan↑, *Bacteria↓, *neuroP↑, *Obesity↓, *cardioP↑, *ROS↓, *MMP↑, *ATP↑, *MFN2↑, *DRP1/DNM1L↓, *FOXO3↑, *NRF2↑, *Ferroptosis↓, *GPx4↑, TumCP↓, HMGB1↓, PI3K↓, Akt↓, Hif1a↓, CDK1↓, CycB/CCNB1↓, TumCCA↑, Apoptosis↑, P53↑, NF-kB↓, ERK↓, p‑PI3K↓, miR-34a↑, Apoptosis↑, CSCs?, *MAPK↓, *HO-1↑, *hepatoP↑, *AMPK↑, *Akt↑, *GSK‐3β↑, *chemoP↑, *Casp3↓, *IRes↝, *GlucoseCon↑, ChemoSen↑, *GSH↑, *SOD↑, *ATF2↑, *GPx↑, *GSTs↑, *AntiAge↑, *Stroke↓, *AChE↓, *ACE/ACE1↓, *ACE2↓, *GutMicro↑, *MPO↓, *H+/K+-ATPase↓, *AntiDiabetic↑, *GLUT4↑, *Obesity↓, *HH↓, *RenoP↑, *BioAv↓, *BioAv↝, *BioAv↑,

Showing Research Papers: 51 to 77 of 77
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 77

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 3,   ARE↑, 1,   Catalase↓, 3,   Catalase↑, 3,   Catalase∅, 1,   Fenton↑, 1,   GCLM↓, 1,   GPx↓, 1,   GPx↑, 2,   GPx4↓, 1,   GSH↓, 6,   GSH↑, 7,   GSR↓, 1,   GSR↑, 2,   GSTs↓, 7,   GSTs↑, 11,   GSTs↝, 1,   GSTs∅, 1,   H2O2↑, 1,   HO-1↓, 2,   HO-1↑, 3,   lipid-P↓, 2,   lipid-P↑, 1,   MDA↑, 1,   MPO↓, 1,   NQO1↓, 1,   NRF2↓, 5,   NRF2↑, 3,   NRF2↝, 1,   ROS↓, 9,   ROS↑, 24,   i-ROS↑, 1,   SOD↓, 4,   SOD↑, 4,   SOD1↑, 1,   SOD2↓, 2,   Thiols↓, 1,   Trx1↑, 1,   TrxR↓, 1,   TrxR1↓, 1,   VitC↓, 1,   VitE↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

FTH1↓, 1,   IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC2↓, 1,   CDC25↓, 1,   EGF↓, 1,   mitResp↓, 1,   mtDam↑, 1,   OCR↓, 1,   PDH↝, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 1,   ACC↑, 1,   AMPK↑, 3,   ATP↓, 1,   ATP↑, 1,   FAO↑, 1,   FASN↓, 1,   glucose↓, 1,   GlucoseCon↓, 1,   GSK‐3β↓, 2,   p‑GSK‐3β↓, 1,   HK2↓, 2,   lactateProd↓, 2,   NADPH↑, 1,   PDK1 / PDPK1↓, 1,   PKM2↓, 1,   SIRT1↓, 2,   SIRT1↑, 1,   Warburg↓, 1,  

Cell Death(tgid=5) ⓘ

AIF↑, 2,   APAF1↑, 3,   Apoptosis↓, 1,   Apoptosis↑, 29,   ASC↓, 1,   BAD↓, 1,   BAD↑, 2,   BAX↑, 14,   Bax:Bcl2↑, 3,   Bcl-2↓, 15,   Bcl-xL↓, 3,   BIM↑, 1,   BNIP3↑, 1,   Casp↑, 1,   Casp↝, 1,   Casp1↓, 1,   Casp12↑, 1,   Casp3↓, 1,   Casp3↑, 21,   Casp6↓, 1,   Casp7↑, 3,   Casp8↓, 1,   Casp8↑, 11,   Casp9↓, 1,   Casp9↑, 12,   proCasp9↓, 1,   Cyt‑c↓, 1,   Cyt‑c↑, 11,   Diablo↑, 2,   DR5↑, 4,   Fas↑, 5,   FasL↑, 1,   iNOS↓, 1,   Mcl-1↓, 2,   MDM2↓, 3,   p‑MDM2↓, 1,   p38↓, 1,   p38↑, 2,   p‑p38↑, 2,   PUMA↓, 1,   PUMA↑, 1,   survivin↓, 5,   TRAIL↑, 1,   TumCD↑, 3,   XIAP↓, 4,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 18,   Akt↑, 1,   p‑Akt↓, 3,   AKT1↓, 1,   CIP2A↓, 1,   EGFR↓, 6,   EGFR↑, 1,   p‑EGFR↓, 1,   ERK↓, 5,   p‑ERK↓, 3,   HER2/EBBR2↓, 1,   HGF/c-Met↓, 1,   IKKα↓, 2,   JAK↓, 1,   JNK↓, 1,   JNK↑, 1,   p‑JNK↓, 1,   p‑JNK↑, 2,   MAP2K1/MEK1↓, 1,   MAPK↓, 4,   MAPK↑, 1,   mTOR↓, 9,   PI3K↓, 14,   p‑PI3K↓, 3,   PKCδ↓, 2,   PTEN↓, 1,   PTEN↑, 1,   RAS↓, 1,   Sp1/3/4↓, 1,   p‑Src↓, 1,   STAT↓, 1,   STAT3↓, 7,   p‑STAT3↓, 1,   p‑STAT3↑, 1,   p‑STAT6↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF2↓, 1,   ATF4↓, 1,   cJun↓, 1,   cMyc↓, 3,   DNMT1↓, 1,   DNMTs↓, 1,   EZH2↓, 1,   FOXM1↓, 1,   FOXO1↓, 1,   FOXO3↝, 1,   H3↓, 1,   H4↓, 1,   HATs↓, 2,   HDAC↓, 4,   HDAC2↓, 2,   HDAC8↓, 1,   miR-200c↑, 1,   miR-34a↑, 2,   MTA2↓, 1,   Myc↓, 1,   OCT4↓, 2,   other↝, 2,   PCAF↓, 1,   SOX4↓, 1,   tumCV?, 1,   tumCV↓, 5,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 4,   p‑eIF2α↑, 1,   ER Stress↑, 1,   HSP27↓, 1,   HSP70/HSPA5↓, 2,   HSP90↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 2,   CTSB↓, 1,   CTSD↓, 1,   LC3II↑, 2,   p62↓, 1,   TumAuto↓, 1,   TumAuto↑, 3,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 1,   DNAdam↓, 1,   DNAdam↑, 9,   hTERT/TERT↓, 2,   P53↑, 14,   P53↝, 1,   p53 Wildtype↓, 1,   PARP↑, 2,   cl‑PARP↓, 1,   cl‑PARP↑, 9,   cl‑PARP1↑, 1,   PCNA↓, 4,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1,   CDK1↑, 1,   CDK2↓, 7,   CDK2↑, 3,   CDK4↓, 6,   CDK6↓, 2,   CDKN1C/p57↓, 1,   CDKN1C/p57↑, 1,   CHK1↓, 1,   cycA1/CCNA1↓, 2,   cycA1/CCNA1↑, 1,   CycB/CCNB1↓, 5,   cycD1/CCND1↓, 12,   cycE/CCNE↓, 2,   cycE/CCNE↑, 1,   E2Fs↓, 2,   Ki-67↓, 3,   MAD↓, 1,   P21↓, 1,   P21↑, 8,   p27/CDKN1B↓, 1,   p27/CDKN1B↑, 2,   p‑RB1↓, 1,   TumCCA↓, 1,   TumCCA↑, 29,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 1,   CD34↓, 1,   cFos↓, 1,   cFos↑, 1,   CSCs?, 1,   CSCs↓, 4,   Gli1↓, 1,   IGF-1↓, 1,   Ki-67↓, 3,   Let-7↑, 1,   NOTCH↓, 3,   NOTCH1↓, 5,   p300↓, 1,   SCF↓, 1,   Shh↓, 1,   TumCG↓, 6,   TumCG↑, 1,   TumCP↓, 13,   Wnt↓, 5,   Wnt↑, 1,  

Migration(tgid=13) ⓘ

AP-1↓, 1,   AXL↓, 1,   Ca+2↑, 3,   i-Ca+2↑, 2,   Cdc42↓, 1,   E-cadherin↓, 2,   E-cadherin↑, 7,   EMT↓, 9,   EpCAM↓, 2,   FAK↓, 4,   p‑FAK↓, 1,   Fibronectin↓, 1,   ITGB1↓, 1,   MET↓, 2,   p‑MET↓, 1,   MMP1↓, 1,   MMP2↓, 13,   MMP3↓, 2,   MMP7↓, 1,   MMP9↓, 13,   MMP9↑, 1,   MMPs↓, 5,   N-cadherin↓, 5,   Rac1↓, 1,   RECK↑, 1,   Rho↓, 1,   Slug?, 1,   Slug↓, 1,   SMAD4↓, 1,   Snail?, 1,   Snail↓, 6,   TGF-β↓, 1,   TGF-β↑, 1,   TIMP1↑, 4,   TIMP2↓, 1,   TIMP2↑, 2,   TumCI↓, 3,   TumCMig↓, 8,   TumMeta↓, 11,   TumMeta↑, 1,   Twist↓, 5,   Tyro3↓, 1,   uPA↓, 2,   uPAR↓, 2,   Vim↓, 4,   Vim↑, 1,   Zeb1↓, 4,   β-catenin/ZEB1↓, 7,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 10,   CD31/PECAM-1↓, 1,   eNOS↓, 1,   Hif1a↓, 7,   NO↓, 1,   NO↑, 1,   VCAM-1↓, 1,   VEGF↓, 10,   VEGFR1↓, 1,   VEGFR2/KDR/Flk1↓, 3,  

Barriers & Transport(tgid=15) ⓘ

CLDN1↓, 2,   GLUT1↓, 1,   MMP↓, 16,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD44↓, 3,   COX1↓, 1,   COX1↑, 1,   COX2/PTGS2↓, 15,   COX2/PTGS2↑, 2,   CXCc↓, 1,   CXCR4↓, 4,   DR4↑, 1,   FOXP3↑, 1,   HMGB1↓, 1,   ICAM-1↓, 2,   IL1↓, 1,   IL10↑, 1,   IL12↓, 1,   IL1β↓, 2,   IL2↑, 1,   IL6↓, 7,   IL8↓, 3,   Imm↑, 1,   Inflam↓, 7,   IRAK1↓, 1,   NF-kB↓, 25,   NLRP3↓, 2,   p50↓, 1,   p65↓, 1,   p‑p65↓, 1,   PD-1↓, 2,   PD-L1↓, 1,   PGE2↓, 7,   PSA↓, 1,   TNF-α↓, 6,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AhR↓, 1,   AR↓, 1,   ERα/ESR1↓, 1,   RANKL↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 3,   BioAv↝, 1,   ChemoSen↑, 19,   CompStab↓, 1,   CompStab↑, 1,   CYP1A1↓, 1,   Dose↝, 7,   Dose∅, 1,   eff↓, 3,   eff↑, 2,   eff↝, 1,   GSTA1↓, 1,   Half-Life↓, 1,   Half-Life↝, 2,   P-gp/ABCB1↑, 1,   P450↓, 2,   P450↝, 1,   RadioS↑, 4,   selectivity↑, 9,   Synergy↑, 10,  

Clinical Biomarkers(tgid=22) ⓘ

AR↓, 1,   CEA↓, 1,   EGFR↓, 6,   EGFR↑, 1,   p‑EGFR↓, 1,   ERα/ESR1↓, 1,   EZH2↓, 1,   FOXM1↓, 1,   HER2/EBBR2↓, 1,   hTERT/TERT↓, 2,   IL6↓, 7,   LDH↓, 1,   Myc↓, 1,   NSE↓, 1,   PD-L1↓, 1,   PSA↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 11,   antiNeop↑, 2,   AntiTum↑, 4,   cachexia↓, 1,   cardioP↑, 6,   chemoP↑, 8,   chemoPv↑, 4,   ChemoSideEff↓, 1,   cognitive↑, 1,   hepatoP↑, 4,   neuroP↑, 3,   OS↑, 2,   radioP↑, 3,   RenoP↑, 1,   Risk↓, 2,   TumVol↓, 4,  

Infection & Microbiome(tgid=24) ⓘ

GutMicro↑, 1,   Sepsis↓, 1,  
Total Targets: 399

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 33,   ARE↑, 3,   Bil↓, 1,   Catalase↓, 1,   Catalase↑, 38,   GPx↑, 25,   GPx1↑, 1,   GPx4↑, 2,   GSH↑, 34,   GSR↓, 1,   GSR↑, 11,   GSTs↓, 5,   GSTs↑, 53,   H2O2↓, 3,   HDL↑, 3,   HO-1↓, 1,   HO-1↑, 16,   Keap1↓, 1,   lipid-P↓, 28,   MDA↓, 16,   MPO↓, 4,   NADH↓, 1,   NOX4↓, 1,   NQO1↑, 5,   Nrf1↑, 1,   NRF2↓, 1,   NRF2↑, 22,   RNS↓, 2,   ROS↓, 47,   mt-ROS↓, 1,   SOD?, 1,   SOD↓, 2,   SOD↑, 42,   SOD1↑, 1,   TAC↑, 5,   TBARS↓, 2,   TBARS↑, 1,   Thiols↑, 1,   Trx↑, 1,   Trx1↑, 1,   VitC↑, 2,   VitE↑, 2,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

DRP1/DNM1L↓, 1,   Insulin↑, 1,   MFN2↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,   3MST/MPST↑, 1,   5LO↓, 2,   ACC↑, 1,   ALAT↓, 7,   AMPK↓, 1,   AMPK↑, 1,   ATP↑, 2,   CBS↑, 1,   CRM↑, 1,   cytoP450↓, 1,   DGAT1↓, 1,   FASN↓, 1,   GlucoseCon↑, 3,   Glycolysis↑, 2,   GSK‐3β↓, 2,   GSK‐3β↑, 1,   H2S↑, 2,   HK2↑, 2,   LDL↓, 3,   NADPH↑, 2,   PFK↑, 1,   PGC1A↑, 1,   PKM2↑, 1,   SIRT1↑, 2,  

Cell Death(tgid=5) ⓘ

BAX↓, 3,   Bcl-2↓, 1,   Bcl-2↑, 2,   Casp3↓, 9,   Casp9↓, 2,   Cyt‑c↓, 2,   Ferroptosis↓, 2,   iNOS↓, 7,   p38↓, 1,   survivin↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 2,   Akt↑, 2,   ERK↓, 2,   p‑JNK↓, 2,   MAPK↓, 3,   mTOR↓, 1,   mTOR↑, 1,   PI3K↓, 1,   PI3K↑, 1,   PTEN↑, 1,   STAT3↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 2,   ATF2↑, 1,   ATF4↑, 1,   cJun↓, 1,   FOXO3↑, 1,   other↓, 1,   other↑, 8,   other↝, 1,   RUNX2↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ER Stress↓, 1,   GRP78/BiP↓, 1,   HSPs↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG3↓, 1,   Beclin-1/ATG6↓, 1,   p62↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 3,   P53↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMP2↑, 1,   HH↓, 1,   IGF-1↓, 1,   neuroG↑, 2,  

Migration(tgid=13) ⓘ

AntiAg↑, 3,   AP-1↓, 2,   COL1↑, 1,   LRP1↑, 1,   MMP13↓, 1,   MMPs↓, 1,   MUC1↑, 1,   p‑T-cadherin↓, 1,   TGF-β↓, 1,   TGF-β1↑, 1,   TregCell↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

LOX1↓, 1,   NO↓, 10,   NO↑, 1,   VCAM-1↓, 1,   VEGF↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 9,   GastroP↑, 2,   GLUT4↑, 3,   H+/K+-ATPase↓, 1,   IBI↑, 1,   MMP↓, 1,   MMP↑, 4,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

AIF1/Iba-1↓, 1,   CD19↑, 1,   CD4+↑, 1,   COX1↓, 2,   COX2/PTGS2↓, 16,   COX2/PTGS2↑, 1,   ICAM-1↓, 2,   IFN-γ↓, 2,   IL1↓, 2,   IL10↑, 5,   IL1β↓, 13,   IL2↓, 1,   IL4↓, 1,   IL4↑, 1,   IL6↓, 12,   IL6↑, 1,   IL8↓, 1,   Imm↑, 3,   Inflam↓, 28,   IRF3↓, 1,   MCP1/CCL2↓, 3,   MyD88↓, 1,   NeuroI↓, 1,   NF-kB↓, 20,   NK cell↑, 1,   PGE2↓, 5,   RAGE↓, 1,   RANTES↓, 1,   TLR2↓, 2,   TLR4↓, 2,   TNF-α↓, 20,  

Cellular Microenvironment(tgid=17) ⓘ

GFAP↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 10,   BChE↓, 1,   BDNF↑, 5,   ChAT↑, 1,   GABA↑, 1,   MAOA↓, 1,   PSD95↑, 1,   SNAP25↑, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,   APP↓, 1,   Aβ↓, 10,   Aβ42↓, 2,   BACE/β-secretase↓, 4,   tau↓, 2,   p‑tau↓, 1,   XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 1,   ACE2↓, 1,   FGF21↑, 1,   GR↑, 2,   PPARα↑, 1,   PPARγ↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 11,   BioAv↑, 15,   BioAv↝, 7,   BioEnh↑, 1,   ChemoSen↑, 1,   CompStab↑, 2,   CYP1A1↑, 1,   CYP1A2↑, 1,   CYP2E1↓, 1,   CYP3A2↓, 1,   Dose↝, 3,   eff↑, 8,   Half-Life↑, 1,   Half-Life↝, 4,   P450↓, 3,   P450↑, 1,   Synergy↑, 5,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 7,   ALP↓, 2,   AST↓, 7,   BG↓, 2,   Bil↓, 1,   BloodF↑, 1,   BMD↑, 1,   BP↓, 5,   BUN↓, 1,   creat↓, 4,   CRP↓, 1,   IL6↓, 12,   IL6↑, 1,   IRes↝, 1,   LDH↓, 3,   NOS2↓, 1,   RAGE↓, 1,   TC↓, 1,   TG/TAG↓, 1,   Urea↓, 1,   VLDL↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 3,   antiAll↑, 4,   AntiArt↑, 3,   AntiCan↑, 6,   AntiDiabetic↓, 1,   AntiDiabetic↑, 5,   antiNeop↑, 1,   antiPs↑, 1,   AntiTum↑, 1,   cardioP↑, 14,   chemoP↑, 3,   chemoPv↑, 1,   cognitive↓, 1,   cognitive↑, 10,   hepatoP↑, 12,   Learn↑, 1,   memory↑, 11,   motorD↓, 1,   motorD↑, 2,   Mucositis↓, 1,   neuroP↑, 26,   Obesity↓, 6,   OS↑, 1,   Pain↓, 1,   radioP↑, 3,   RenoP↑, 9,   Sleep↑, 1,   Strength↑, 1,   Stroke↓, 2,   toxicity↓, 5,   toxicity↑, 1,   toxicity↝, 3,   Weight↓, 1,   Wound Healing↑, 3,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 3,   AntiFungal↑, 1,   Bacteria↓, 6,   GutMicro↑, 5,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 1,  
Total Targets: 266

Scientific Paper Hit Count for: GSTs, Glutathione S-transferases
5 Fisetin
5 Luteolin
5 Lycopene
4 Curcumin
4 Thymoquinone
3 Eugenol
3 Silymarin (Milk Thistle) silibinin
2 Ashwagandha(Withaferin A)
2 Chrysin
2 Crocetin
2 Carvone
2 Resveratrol
2 Ellagic acid
2 Moringa oleifera
2 Piperine
2 Sulforaphane (mainly Broccoli)
1 Silver-NanoParticles
1 Allicin (mainly Garlic)
1 Alpha-Lipoic-Acid
1 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
1 Anethole/trans-Anethole
1 Baicalein
1 Betulinic acid
1 Carnosic acid
1 Centella asiatica / Gotu kola → asiaticoside
1 Chlorogenic acid
1 Chocolate
1 Cynara scolymus/Globe Artichoke/Artichoke Extract
1 Chemotherapy
1 diet Methionine-Restricted Diet
1 Diindolylmethane
1 Indole-3-carbinol
1 EGCG (Epigallocatechin Gallate)
1 Gallic acid
1 Garcinol
1 Germanium inorganic
1 Geraniol
1 hydrogen sulfide
1 Isoliquiritigenin
1 isoorientin
1 Kaempferol
1 Licorice
1 Piperlongumine
1 Rosmarinic acid
1 α-Santalol/Sandalwood oil
1 Selenium NanoParticles
1 Sesame seeds and Oil
1 Thymol-Thymus vulgaris
1 Ursolic acid
1 Vitexin
1 Isovitexin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1153  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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