chemoP Cancer Research Results

chemoP, ChemoProtective: Click to Expand ⟱
Source:
Type:
Protects normal cells against the effect of Chemo.
Scientific Papers found: Click to Expand⟱
4769- CoQ10,    CoQ10 Is Key for Cellular Energy and Cancer Support
- Review, Var, NA
Risk↓, TumCG↓, angioG↓, TumCD↑, *toxicity↓, *BioAv↑, MMPs↓, Inflam↓, chemoP↑, cardioP↑, *ROS↓, *toxicity↝, Dose?,
5792- CRMs,  HCA,  CUR,  EGCG,  GAR  Caloric restriction mimetics: natural/physiological pharmacological autophagy inducers
- Review, Nor, NA
*CRM↓, *Dose?, *AntiAge↑, *Acetyl-CoA↓, *SIRT1↑, *AMPK↑, *mTORC1↓, *AntiAge↑, chemoP↑,
6300- Cro,    Interaction of saffron and its constituents with Nrf2 signaling pathway: A review
- Review, Nor, NA - Review, Arthritis, NA
*antiOx↑, *Inflam↓, *AntiTum↑, *hepatoP↑, *cardioP↑, *neuroP↑, *NRF2↑, *NF-kB↓, *iNOS↓, *COX2/PTGS2↓, *IL6↓, *IL10↓, *IL1β↓, *TNF-α↓, *HO-1↑, ROS↑, NQO1↑, NRF2↑, HO-1↑, NQO2↑, LDHA↓, ATP↓, *hepatoP↑, *SOD↑, *Catalase↑, *GPx↑, *NRF2↑, *ROS↓, *cardioP↑, *ER Stress↓, *GRP78/BiP↓, *CHOP/DDIT3↓, *Apoptosis↓, *miR-34a↓, *SIRT1↑, chemoP↑,
6409- CUR,    Curcumin prevents cisplatin-induced renal alterations in mitochondrial bioenergetics and dynamic
- in-vivo, Nor, NA
*FIS1↓, *SIRT3↑, *PTEN↓, *chemoP↑,
6214- CUR,    Curcumin Nanoparticles-related Non-invasive Tumor Therapy, and Cardiotoxicity Relieve
- Review, CardioV, NA
TumCD↓, TumCI↓, *Inflam↓, *antiOx↓, *AntiTum↓, NF-kB↓, COX2/PTGS2↓, Casp9↓, ROS↑, BioAv↑, RadioS↑, ChemoSen↑, Imm↑, PhotoS↑, sonoS↑, 5LO↓, iNOS↓, IL2↓, TNF-α↓, Casp9↑, Casp3↑, Bcl-2↓, BAX↑, Apoptosis↑, ER Stress↑, cycD1/CCND1↓, CDK2↓, CycB/CCNB1↓, TumCCA↑, MMPs↓, *radioP↑, chemoP↑, hepatoP↑, cardioP↑, Synergy↑, PhotoS↑, eff↑, ROS↑, GSH↓,
6230- CUR,    Dual redox effects of 2,6-bis-(4-hydroxyl-3-methoxybenzylidene) cyclohexanone (BHMC) on human liver cancer cells, HepG2 via ROS, glutathione and Nrf2/Keap1 pathway
- in-vitro, Liver, HepG2
chemoP↑, selectivity↑, *BioAv↓, *BioAv↑, ROS↑, ROS↓, ROS↑,
1485- CUR,  Chemo,  Rad,    Curcumin, the golden spice from Indian saffron, is a chemosensitizer and radiosensitizer for tumors and chemoprotector and radioprotector for normal organs
- Review, Var, NA
ChemoSen↑, NF-kB↓, *STAT3↓, *COX2/PTGS2↓, *Akt↓, *NRF2↑, *HO-1↑, *GPx↑, *NADPH↑, *GSH↑, *ROS↓, *p300↓, radioP↑, chemoP↑, RadioS↑,
1510- CUR,  Chemo,    Combination therapy in combating cancer
- Review, Var, NA
*NRF2↑, *GSH↑, *ROS↓, ChemoSideEff↓, ChemoSen↑, OS↓, chemoP↑,
4651- CUR,    Targeting cancer stem cells by curcumin and clinical applications
- Review, Var, NA
CSCs↓, *toxicity↓, *BioAv↝, chemoP↑,
6745- DHA,    Omega-3 fatty acid DHA induces ferroptosis in colorectal cancer patient-derived organoids and drug-tolerant cells
- in-vitro, CRC, HT29
tumCV↓, selectivity↑, Ferroptosis↑, lipid-P↑, mt-ROS↑, ChemoSen↑, *toxicity↓, TumCG↓, Synergy↑, Synergy↑, Dose↝, mtDam↑, *Inflam↓, *chemoP↑, Dose↑,
6753- DHA,    Docosahexaenoic Acid (DHA) for Women With Breast Cancer in the Neoadjuvant Setting (DHA-WIN)
- Trial, BC, NA
ChemoSen↑, TumCG↓, Weight↑, chemoP↑, Dose↝,
2156- dietP,    Phytochemical-rich vegetable and fruit juice alleviates oral mucositis during concurrent chemoradiotherapy in patients with locally advanced head and neck cancer
- Human, HNSCC, NA
chemoP↑, radioP↑, eff↑,
5070- dietSTF,    A review of fasting effects on the response of cancer to chemotherapy
- Review, Var, NA
chemoP↑, ChemoSen↑, *DNArepair↑, *Apoptosis↓, *CD8+↑, UPR↑, eff↝, TumAuto↑,
5071- dietSTF,    Unraveling the impact of intermittent fasting in cancer prevention, mitigation, and treatment: A narrative review
- Review, Var, NA - Review, AD, NA
Risk↓, TumCMig↓, IGF-1↓, TumAuto↑, Inflam↓, ChemoSen↑, Apoptosis↑, chemoP↑, *glucose↓, *AntiDiabetic↑, *cardioP↑, *LDL↓, *BP↓, *neuroP↑, *cognitive↑, *memory↑, *OS↑, *QoL↑, Imm↑, TumCG↓, ChemoSideEff↓, QoL↑,
3708- dietSTF,    Fasting as a Therapy in Neurological Disease
- Review, Nor, NA
*PGC-1α↑, *AMPK↑, *adiP↑, *glucose↓, *Insulin↓, *mTOR↓, *IL6↓, *TNF-α↓, *cognitive↑, *Inflam↓, *eff↑, *neuroP↑, ChemoSen↑, eff↓, chemoP↑, *eff↑,
8844- DIM,  I3C,    Unveiling the Multifaceted Pharmacological Actions of Indole-3-Carbinol and Diindolylmethane: A Comprehensive Review
- Review, Var, NA - Review, AD, NA - Review, Stroke, NA
*antiOx↑, *Inflam↓, *Apoptosis↓, *Imm↝, *BioAv↝, *Half-Life↝, *PKCδ↓, *TGF-β1↓, *PPARγ↓, *CEBPA↓, *FABP4↓, *AMPKα↑, *MCP1/CCL2↓, *IL6↓, *TNF-α↓, *Akt↑, *Inflam↓, *TMAO↓, *SREBF2⇅, *memfluid↑, *GutMicro↑, *Obesity↓, *hepatoP↑, *neuroP↑, *AntiAg↓, *Stroke↓, *AntiAg↓, *HDAC↑, *IL1β↓, *IL6↓, *iNOS↓, *IL4↑, *IL10↑, *Synergy↑, *compI↑, *ROS↓, *AChE↓, *BChE↓, *MAOA↓, *MAOB↓, *cognitive↑, *Analgesic↑, *Pain↓, *BDNF↑, *TrkB↑, *Akt↑, *antiOx↑, *Apoptosis↓, *cardioP↑, *chemoP↑, *AntiThr↑, *uPA↑, *NRF2↑, *ARE↑, *HO-1↑, *Bacteria↓, *TOP1↓, *AntiFungal↑, *AntiViral↑, *radioP↑, *Synergy↑, *hepatoP↑, *Diar↓, *ChemoSen↑, *Telomerase↓, *BioAv↓,
6322- DRE,  LGE,    Dandelion Root and Lemongrass Extracts Induce Apoptosis, Enhance Chemotherapeutic Efficacy, and Reduce Tumour Xenograft Growth In Vivo in Prostate Cancer
- vitro+vivo, Pca, DU145
AntiCan↑, ChemoSen↑, Dose↝, *ROS↓, Apoptosis↑, selectivity↑, *toxicity↓, *chemoP↑, eff↓, ROS↑,
6353- DRE,  Cisplatin,    Insights Into Protective Mechanisms of Dandelion Leaf Extract Against Cisplatin-Induced Nephrotoxicity in Rats: Role of Inhibitory Effect on Inflammatory and Apoptotic Pathways
- in-vivo, Nor, NA
*antiOx↑, *Inflam↓, *Apoptosis↓, *NF-kB↓, *Cyt‑c↓, *DNAdam↓, *GSH↑, *SOD↑, *ALB↝, *creat↓, *BUN↓, *RenoP↑, *lipid-P↓, *TNF-α↓, *Casp3↓, *Casp9↓, *chemoP↑,
6364- DRE,    Dandelion Root Extract Sensitizes Leukemia Cells to VP-16 Induced Cell Death
- in-vitro, CLL, NA
TumCP↓, MMP↓, ROS↑, TumCD↑, ChemoSen↑, chemoP↑, QoL↑,
4916- DSF,  Cu,    The immunomodulatory function and antitumor effect of disulfiram: paving the way for novel cancer therapeutics
- Review, Var, NA
TumCP↓, TumCMig↓, TumCI↓, Synergy↑, Imm↑, ROS↑, NF-kB↓, chemoP↑, JNK↑, FOXO↑, Myc↑, TumCCA↑, Apoptosis↑, RadioS↑, PD-L1↑, Synergy↑, CSCs↓, Dose↝, Half-Life↑,
4832- EA,    Experimental Evidence of the Antitumor, Antimetastatic and Antiangiogenic Activity of Ellagic Acid
- Review, Var, NA
*antiOx↑, *AntiCan↑, TumCMig↓, angioG↓, ChemoSen↑, RadioS↑, *chemoP↑, *BioAv↓, eff↓, selectivity↑, MMP2↓, MMP9↓, VEGF↓, TumCCA↑, Apoptosis↑, ROS↑, BioAv↑,
6802- EA,    Support ellagic acid therapy in patients with hormone refractory prostate cancer (HRPC) on standard chemotherapy using vinorelbine and estramustine phosphate
- Human, Pca, NA
*toxicity↓, chemoP↑, Neut↑, PSA↓, Dose↝,
6621- Ech,  Cisplatin,    Experimental Evaluation of Protective Activity of Echinacea pallida against Cisplatin Toxicity
- in-vivo, Nor, NA
chemoP↑, RenoP↑,
3201- EGCG,    Epigallocatechin Gallate (EGCG): Pharmacological Properties, Biological Activities and Therapeutic Potential
- Review, Var, NA
*AntiCan↑, *cardioP↑, *neuroP↑, *BioAv↝, *BioAv↓, *BioAv↓, *Dose↝, *Half-Life↝, *BioAv↑, *BBB↑, *hepatoP↓, *other↓, *Inflam↓, *NF-kB↓, *AP-1↓, *iNOS↓, *COX2/PTGS2↓, *ROS↓, *RNS↓, *IL8↓, *JAK↓, *PDGFR-BB↓, *IGF-1R↓, *MMP2↓, *P53↓, *NRF2↑, *TNF-α↓, *IL6↓, *E2Fs↑, *SOD1↑, *SOD2↑, Casp3↑, Cyt‑c↑, PARP↑, DNMTs↓, Telomerase↓, Hif1a↓, MMPs↓, BAX↑, Bak↑, Bcl-2↓, Bcl-xL↓, P53↑, PTEN↑, TumCP↓, MAPK↓, HGF/c-Met↓, TIMP1↑, HDAC↓, MMP9↓, uPA↓, GlutMet↓, ChemoSen↑, chemoP↑,
26- EGCG,  QC,  docx,    Green tea and quercetin sensitize PC-3 xenograft prostate tumors to docetaxel chemotherapy
- vitro+vivo, Pca, PC3
BAD↓, cl‑PARP↑, Casp7↑, IκB↓, Ki-67↓, VEGF↓, EGFR↓, FGF↓, TGF-β↓, TNF-α↓, SCF↓, Bax:Bcl2↑, NF-kB↓, chemoP↑, ChemoSen↑, TumVol↓,
6823- EMD,    Role of emodin to prevent gastrointestinal cancers: recent trends and future prospective
- Review, Var, NA
AntiCan↑, *antiOx↑, *chemoP↑, *Inflam↓, TumCP↓, TumMeta↓, TumCCA↑, MAPK↑, BAX↑, Casp↑, ROS↑, *BioAv↓, other↝, TumCI↓, EMT↓, TumCG↑, Apoptosis↑, TumCP↑, MMP2↓, Casp3↑, ChemoSen↑, PI3K↓, Akt↓, Cyt‑c↑, cl‑PARP↑, MMP↓, Warburg↓, HK2↓, PKM2↓, LDHA↓, mtDam↑, Apoptosis↑, N-cadherin↓, Vim↓, E-cadherin↑, eff↑, eff↑, eff↑, toxicity↝, toxicity↑,
6325- Eug,    Anticancer Properties of Eugenol: A Review
- Review, Var, NA
*antiOx↑, *AntiCan↑, *Inflam↓, TumCD↑, TumCCA↑, TumCMig↓, TumMeta↓, angioG↓, ChemoSen↑, chemoP↑, *BioAv↝, *BioAv↑, *BioAv↑, *BioAv↑, *Bacteria↓, *ROS↓, *IL6↓, *COX2/PTGS2↓, *TNF-α↓, *lipid-P↓, *SOD1↑, *Catalase↑, *GPx1↑, *GSTs↑, ROS↑, MMP↓, Apoptosis↑, COX2/PTGS2↓, TumCCA↑, E2Fs↓, PI3K↓, Akt↓, MMPs↓, CSCs↓, OCT4↓, CD44↓, EpCAM↓, NOTCH1↓, TumVol↓, Casp3↑, P53↑, cl‑PARP↑, MMP2↓, MMP9↓, TIMP1↑, ALDH↓, NF-kB↓, *toxicity↓,
2150- Ex,    Roles and molecular mechanisms of physical exercise in cancer prevention and treatment
- Review, Var, NA
eff↓, Dose↝, TumCP↓, Apoptosis↓, ChemoSen↑, chemoP↑,
6910- FIS,    Exploring the therapeutic promise of fisetin: molecular mechanisms and clinical aspects in lung cancer
- in-vitro, Lung, NA
Apoptosis↑, TumCP↓, TumCMig↓, TumCI↓, TumAuto↝, ChemoSen↑, RadioS↑, chemoP↑, BioAv↓, Half-Life↓,
2827- FIS,    The Potential Role of Fisetin, a Flavonoid in Cancer Prevention and Treatment
- Review, Var, NA
*antiOx↑, *Inflam↓, neuroP↑, hepatoP↑, RenoP↑, cycD1/CCND1↓, TumCCA↑, MMPs↓, VEGF↓, MAPK↓, NF-kB↓, angioG↓, Beclin-1/ATG6↑, LC3s↑, ATG5↑, Bcl-2↓, BAX↑, Casp↑, TNF-α↓, Half-Life↓, MMP↓, mt-ROS↑, cl‑PARP↑, CDK2↓, CDK4↓, Cyt‑c↑, Diablo↑, DR5↑, Fas↑, PCNA↓, Ki-67↓, p‑H3↓, chemoP↑, Ca+2↑, Dose↝, CDC25↓, CDC2↓, CHK1↑, Chk2↑, ATM↑, PCK1↓, RAS↓, p‑p38↓, Rho↓, uPA↓, MMP7↓, MMP13↓, GSK‐3β↑, E-cadherin↑, survivin↓, VEGFR2/KDR/Flk1↓, IAP2/BIRC3↓, STAT3↓, JAK1↓, mTORC1↓, mTORC2↓, NRF2↑,
6981- Form,    Formononetin: a review of its source, pharmacology, drug combination, toxicity, derivatives, and drug delivery systems
- Review, Var, NA - Review, AD, NA - Review, PSA, NA
BioAv↝, *memory↑, *ROS↓, *AChE↓, *NF-kB↓, *Keap1↝, *NRF2↑, *Inflam↓, *PGC-1α↝, *HO-1↓, *p‑tau↓, *cognitive↑, *BDNF↑, *5HT↑, *Stroke↓, *PARP1↓, *AIF↓, *Casp3↓, NP/CIPN↓, *neuroP↑, *NGF↑, *TNF-α↓, *IL1β↓, *IL18↓, *IL6↓, *VCAM-1↓, *pol-M2 MC↑, *hepatoP↑, *AST↓, *ALAT↓, *LC3II↑, *Beclin-1/ATG6↑, *p62↑, *COX2/PTGS2↑, *MMP↑, *ATP↑, *GSH↑, *Catalase↑, *GPx↑, *MDA↓, *antiPs↑, *AntiDiabetic↑, *glucose↓, *Insulin↑, *GutMicro↑, *Obesity↓, COX2/PTGS2↓, cycD1/CCND1↓, TumCCA↑, EGFR↓, GSK‐3β↑, Mcl-1↓, *toxicity↓, TumCP↓, Hif1a↓, VEGF↓, ERK↓, LAMs↓, Cyt‑c↑, Casp9↑, Casp3↑, PARP↑, TumCD↑, mitA↑, BACH1↓, P53↓, ROS↑, PD-1↓, NF-kB↓, *Bacteria↓, *AntiViral↑, *mt-ROS?, *PI3K↓, *chemoP↑, ChemoSen↑, Synergy↑, *toxicity↓, *BioAv↑, *BioAv↑, *Synergy↑, *antiAll↑,
8590- FS,    The Effect of Flaxseed in Breast Cancer: A Literature Review
- Review, BC, NA
*BioAv↑, *antiOx↑, *TC↓, *cardioP↑, *Ingr↑, *Ingr↑, chemoP↑, ChemoSen↑, TumVol↓, TumCG↓, Risk↓, Risk↓, Ki-67↓, OS↑, TumMeta↓,
8591- FS,  doxoR,  carbop,    Flaxseed Lignans Enhance the Cytotoxicity of Chemotherapeutic Agents against Breast Cancer Cell Lines MDA-MB-231 and SKBR3
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, SkBr3
ChemoSen?, Synergy↑, chemoP↑,
7013- Fuc,    Fucoidan-based nanoparticles for colorectal cancer therapy: Mechanisms and preclinical insights
- Review, CRC, NA
*Inflam↓, *antiOx↑, AntiCan↑, BioAv↑, Apoptosis↑, angioG↓, Imm↝, ChemoSen↑, chemoP↑,
7026- Fuc,    Fucoidan
- Review, AD, NA
*Inflam↓, *ROS↓, *BioAv↓, *GutMicro↑, *neuroP↑, *glucose↝, *AntiThr↑, *chemoP↑, *Half-Life↝, *BBB∅, *AntiAge↑, Risk↑,
7009- Fuc,    Effects of Fucoidan and Chemotherapeutic Agent Combinations on Malignant and Non-malignant Breast Cell Lines
- in-vitro, BC, MCF7 - in-vitro, Nor, MCF12A
selectivity↑, TumCCA↑, Casp3↑, Casp7↑, Casp9↑, ChemoSen↑, chemoP↑,
7007- Fuc,    The Therapeutic Potential of the Anticancer Activity of Fucoidan: Current Advances and Hurdles
- Review, Var, NA
TumCCA↑, Apoptosis↑, NK cell↑, chemoP↑, TumCG↓, *Inflam↓, *antiOx↑, *AntiThr↑, *AntiViral↑, angioG↓, ChemoSen↑, ROS↑, GSH↓, mtDam↓, MMP↓, DNMT3B↓, TumCG↓, Dose↝, Dose↝, QoL∅, fatigue∅, Dose↝,
4022- FulvicA,  Chemo,    Shilajit potentiates the effect of chemotherapeutic drugs and mitigates metastasis induced liver and kidney damages in osteosarcoma rats
- in-vivo, OS, NA
AST↓, ALAT↓, ALP↓, Bil↝, creat↓, uricA↓, ChemoSen↑, chemoP↑,
4029- FulvicA,  Chemo,    Shilajit mitigates chemotherapeutic drug-induced testicular toxicity: Study on testicular germ cell dynamics, steroidogenesis modulation, and Nrf-2/Keap-1 signaling
- in-vivo, Var, NA
*other↑, *PCNA↑, *SOD↑, *lipid-P↓, *NRF2↑, *Keap1↓, *chemoP↑,
7032- GA,  Cisplatin,    Gallic acid: a polyphenolic compound potentiates the therapeutic efficacy of cisplatin in human breast cancer cells
- in-vitro, BC, MCF7 - in-vitro, Nor, MCF10
ChemoSen↑, tumCV↓, Apoptosis↑, selectivity↑, *ROS↓, Synergy↑, *chemoP↑, Dose↝,
7084- GAR,    A unique in vivo pharmacokinetic profile, in vitro metabolic stability and hepatic first-pass metabolism of garcinol, a promising novel anticancer phytoconstituent, by liquid chromatography–mass spectrometry
- in-vivo, Nor, NA
*BioAv↝, *Dose↝, *Inflam↓, *antiOx↑, *chemoPv↑, Wnt↓, β-catenin/ZEB1↓, ERK↓, PI3K↓, Akt↓, NF-kB↓, STAT3↓, TumCP↓, antiNeop↑, ChemoSen↑, chemoP↑,
7250- Gink,    Ginkgetin from Ginkgo biloba: mechanistic insights into anticancer efficacy
- Review, Var, NA
AntiCan↑, toxicity↓, ChemoSen↑, chemoP↑, TumCCA↑, TumCD↑, TumCI↓, angioG↓, Ferroptosis↑, Imm↑, MOMP↑, Cyt‑c↑, Casp↑, cl‑Casp3↑, cl‑Casp9↑, cl‑PARP↑, Apoptosis↑, ROS↑, TumAuto↑, GPx4↓, xCT/SLC7A11↓, RadioS↑, NRF2↓, HO-1↓, HSP90↓, Dose↝, Dose↝, BioAv↓, BioAv↝, CYP3A4↓, *toxicity↑, *toxicity↝,
4510- GLA,    Gamma-linolenic acid therapy of human glioma-a review of in vitro, in vivo, and clinical studies
- Review, GBM, NA
Apoptosis↑, selectivity↑, eff↓, ROS↑, lipid-P↑, P53↑, radioP↑, chemoP↑,
7482- H2,    Molecular Hydrogen Therapy: Mechanisms, Delivery Methods, Preventive, and Therapeutic Application
- Review, Var, NA - Review, IBD, NA - Review, Stroke, NA - Review, Sepsis, NA - Review, AD, NA
Dose↝, *Inflam↓, *IL1β↓, *IL6↓, *TNF-α↓, *neuroP↑, *mTOR↓, *IL10↑, *TGF-β↑, *Sepsis↓, *NRF2↑, *antiOx↑, *Catalase↑, *SOD↑, *GPx↑, *ROS↓, *HO-1↑, *PI3K↑, *Akt↑, *hepatoP↑, *MPO↓, *cardioP↑, CDK4↓, CDK6↑, CD47↓, PI3K↓, Akt↓, Hif1a↓, selectivity↑, *MMP↑, *ATP↑, *ER Stress↓, *CHOP/DDIT3↓, *Casp12↓, *GRP78/BiP↓, *p38↓, *p‑JNK↓, *LC3‑Ⅱ/LC3‑Ⅰ↑, *p‑eIF2α↓, *ATF4↓, *XBP-1↓, *Imm↑, *IFN-γ↓, *IL4↓, *GranB/GZMB↓, NK cell↑, radioP↑, *CD4+↑, CD8+↑, *Dose↝, *other↑, *Dose↝, *antiPs↑, *BioAv↝, *GutMicro↑, Dose↝, *IBI↑, TumCP↓, TumCI↓, TumCMig↓, CD8+↑, PGC-1α↑, Akt↓, SCD1↓, *MDA↓, Synergy↑, *APP↓, *BACE/β-secretase↓, *Aβ↓, *cognitive↑, *neuroP↑, NP/CIPN↓, *Stroke↓, *NLRP3↓, *ALAT↓, *AST↓, *LPS↓, *hepatoP↑, chemoP↑, *creat↓, *Urea↓, *RenoP↑, *eff↑, Apoptosis↑, XIAP↓, IAP2/BIRC3↓, TumVol↓, MALAT1↓, EZH2↓, miR-124-3p↓, eff↑, ChemoSen↑, *compII↑, *compIII↑, *LDL↓, *Obesity↓, QoL↑, PFS↑, *antiAll↑,
7483- H2,  Cisplatin,    Molecular hydrogen attenuates cisplatin-induced nephrotoxicity by modulating β-hydroxybutyrate metabolism
- in-vivo, Nor, HK-2
RenoP↑, BHB↑, HMGCS2↑, chemoP↑, *IL2↓, *IL6↓, *MCP1/CCL2↓, *TNF-α↓, *KeyT↝, *Inflam↓, *ROS↓, *MMP↑, *ATP↑, *MFN2↑, *PGC-1α↑, *BUN↓, *creat↓,
7489- H2,    Molecular Hydrogen in the Treatment of Respiratory Diseases
- Review, Asthma, NA
*antiOx↑, *Inflam↓, *Apoptosis↓, *Dose↓, *Dose↝, *eff↑, *ROS↓, *RNS↓, *NRF2↑, *HO-1↑, *Fenton↓, *NLRP3↓, *NADPH↓, *NOX4↓, *NOX↓, *MPO↓, *NF-kB↓, *TNF-α↓, *IL6↓, *IL1β↓, *HMGB1↓, *IL4↑, *IL10↑, *M2 MC↑, *Treg lymp↝, *Bcl-2↑, *Bcl-xL↑, *PI3K↑, *Akt↑, *JAK2↑, *STAT3↑, *Dose↑, *CD4+↑, *CD25+↑, *FOXP3↑, *MDA↓, *SOD↑, *Catalase↑, *Casp3↓, *Casp9↓, *TBARS↓, *SpO2↑, *VitE↓, *OS↑, *Weight↑, *DNAdam↓, *PGE2↓, *MCP1/CCL2↓, *lipid-P↓, *TumCP↓, *tumCV↓, *TumCMig↓, *TumCI↓, TumW↓, TumVol↓, selectivity↑, QoL↑, ChemoSen↑, chemoP↑, radioP↑, ROS↑, NLRP3↑, Casp3↑, VEGF↓, Wnt↓, β-catenin/ZEB1↓, *antiAll↑,
7492- H2,  Chemo,    Molecular Hydrogen Protects against Various Tissue Injuries from Side Effects of Anticancer Drugs by Reducing Oxidative Stress and Inflammation
- Review, Var, NA
*ROS↓, *antiOx↑, *Inflam↓, *chemoP↑, AntiCan↑, ChemoSen↑, chemoP↑, *BUN↓, *creat↓, *TUNEL↓, *MDA↓, *SOD↑, *Catalase↑, *NRF2↑, *BNP↓, *AST↓, *ALAT↓, *TNF-α↓, *IL1β↓, *IL6↓, *Casp3↓, *Casp9↓, *GPx↑, *E-cadherin↑, *Vim↓, *α-SMA↓, *COL1↓, *cardioP↑, *hepatoP↑, *p‑mTOR↓, *EMT↓, eff∅, *LPS↓, *TLR4↓, radioP↑,
2525- H2,    Hydrogen-Rich Saline Attenuates Cardiac and Hepatic Injury in Doxorubicin Rat Model by Inhibiting Inflammation and Apoptosis
- in-vivo, Var, NA
OS↓, cardioP↑, *AST↓, ALAT↓, *ROS↓, *MDA↓, *hepatoP↑, *Inflam↓, chemoP↑,
2522- H2,    A Systematic Review of Molecular Hydrogen Therapy in Cancer Management
- Review, Var, NA
chemoP↑, OS↑, QoL↑, TumVol↑, ROS↑, AntiTum↑, other↝,
2521- H2,    Oxyhydrogen Gas: A Promising Therapeutic Approach for Lung, Breast and Colorectal Cancer
- Review, CRC, NA - Review, Lung, NA - Review, BC, NA
Inflam↑, ROS↓, ChemoSen↑, p‑PI3K↓, p‑Akt↓, QoL↑, GutMicro↑, chemoP↑, radioP↑, *NRF2↑, *Catalase↑, *GPx↑, *HO-1↑, *SOD↑, *TNF-α↓, *IL4↓, *IL6↓, ChemoSen↑, Appetite↑, cognitive↑, Pain↓, Sleep↑, other?,

Showing Research Papers: 51 to 100 of 228
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 228

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 8,   antiOx⇅, 1,   Bil↝, 1,   Catalase↓, 2,   Catalase↑, 4,   GPx↓, 1,   GPx↑, 2,   GPx4↓, 3,   GSH↓, 15,   GSH↑, 3,   GSH∅, 1,   GSR↓, 1,   GSTs↓, 1,   GSTs↑, 1,   H2O2↑, 1,   i-H2O2↓, 1,   HO-1↓, 3,   HO-1↑, 3,   HO-2↑, 1,   i-Iron↓, 1,   c-Iron↑, 1,   lipid-P↓, 4,   lipid-P↑, 4,   MDA↓, 2,   MDA↑, 1,   NOX4↑, 1,   NQO1↓, 1,   NQO1↑, 1,   Nrf1↑, 1,   NRF2↓, 5,   NRF2↑, 6,   Prx6↑, 1,   PrxI↓, 1,   PrxI∅, 1,   PrxII↑, 1,   PrxII∅, 1,   ROS↓, 11,   ROS↑, 76,   ROS⇅, 6,   ROS↝, 1,   ROS∅, 1,   i-ROS↑, 1,   mt-ROS↑, 3,   SOD↓, 3,   SOD↑, 3,   SOD2↓, 2,   Thiols↓, 1,   Trx↓, 1,   TrxR↑, 1,   uricA↓, 1,   VitC↓, 1,   VitE↓, 1,   xCT/SLC7A11↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 2,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC2↓, 1,   CDC25↓, 1,   compI↓, 2,   compII↓, 1,   EGF↓, 1,   ETC↓, 2,   Insulin↓, 1,   MKK7↓, 1,   mtDam↓, 1,   mtDam↑, 5,   PGC-1α↑, 1,   SIRT3↓, 1,   SIRT3↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX?, 1,   5LO↓, 1,   ACSL4↑, 2,   ALAT↓, 4,   AMP↑, 1,   AMPK↑, 2,   p‑AMT/GCST/T-protein↑, 1,   ATP↓, 4,   BHB↑, 1,   FASN↓, 3,   GLO-I↓, 1,   glucoNG↓, 1,   glucose↝, 1,   GlucoseCon↓, 1,   GlucoseCon∅, 1,   GlutMet↓, 1,   Glycolysis↓, 4,   GSK‐3β↓, 3,   GSK‐3β↑, 5,   p‑GSK‐3β↓, 1,   H2S↑, 1,   HK2↓, 2,   HMG-CoA↓, 1,   HMGCS2↑, 1,   lactateProd∅, 1,   LDHA↓, 3,   lipoGen↓, 1,   NAD↑, 1,   NADPH↓, 1,   PCK1↓, 1,   PDK1 / PDPK1↓, 2,   PFK1↓, 1,   PKM2↓, 3,   PPP↓, 1,   SCD1↓, 1,   SIRT1↓, 2,   SIRT1↑, 2,   SREBP1/SREBF1↓, 1,   TCA↓, 1,   Warburg↓, 1,  

Cell Death(tgid=5) ⓘ

AIF↑, 4,   APAF1↑, 3,   Apoptosis?, 1,   Apoptosis↓, 4,   Apoptosis↑, 61,   m-Apoptosis↑, 1,   ASC↓, 1,   BAD↓, 1,   BAD↑, 1,   Bak↑, 2,   BAX↓, 1,   BAX↑, 29,   Bax:Bcl2↑, 3,   Bcl-2↓, 31,   Bcl-2↑, 1,   Bcl-xL↓, 8,   BIM↓, 1,   BIM↑, 1,   Casp↑, 19,   Casp1↓, 1,   Casp12↑, 1,   Casp3↑, 30,   cl‑Casp3↑, 3,   proCasp3↑, 1,   Casp7↑, 4,   cl‑Casp7↑, 2,   Casp8↑, 7,   proCasp8↑, 1,   Casp9↓, 2,   Casp9↑, 17,   cl‑Casp9↑, 3,   proCasp9↑, 1,   cFLIP↓, 1,   Cyt‑c↑, 21,   Cyt‑c↝, 1,   Diablo↑, 2,   DR5↑, 5,   Fas↓, 1,   Fas↑, 5,   FasL↓, 1,   FasL↑, 1,   Ferroptosis↑, 5,   GSDMD↑, 1,   IAP1↓, 4,   IAP2/BIRC3↓, 4,   iNOS↓, 6,   Mcl-1↓, 6,   p‑MDM2↓, 1,   MOMP↑, 1,   p38↓, 1,   p38↑, 6,   p‑p38↓, 3,   p‑p38↑, 2,   Pyro↑, 1,   survivin↓, 15,   TumCD↓, 1,   TumCD↑, 8,   XIAP↓, 7,   YAP/TEAD↓, 1,   YAP/TEAD↝, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 37,   Akt↑, 2,   p‑Akt↓, 7,   p‑Akt↑, 1,   cMET↓, 1,   p‑cMET↑, 1,   cSrc↓, 1,   EGFR↓, 8,   EGFR↑, 1,   p‑EGFR↓, 1,   ERK↓, 21,   p‑ERK↓, 3,   p‑ERK↑, 1,   HCAR2↑, 1,   HER2/EBBR2↓, 1,   HGF/c-Met↓, 2,   IKKα↓, 1,   IκB↓, 1,   JAK↓, 2,   JAK1↓, 2,   JAK2↓, 1,   JNK↓, 2,   JNK↑, 4,   p‑JNK↓, 1,   p‑JNK↑, 3,   MAPK↓, 13,   MAPK↑, 4,   MEK↓, 2,   MKK4↓, 1,   mTOR↓, 15,   p‑mTOR↓, 1,   mTORC2↓, 1,   p42↓, 1,   p‑p70S6↑, 1,   PI3K↓, 30,   PI3K↑, 2,   p‑PI3K↓, 3,   PKCδ↓, 3,   PTEN↓, 1,   PTEN↑, 4,   Raf↓, 2,   e-Raf↓, 1,   RAS↓, 5,   RAS↑, 1,   Sp1/3/4↓, 1,   p‑Src↓, 1,   STAT↓, 2,   STAT3↓, 17,   p‑STAT3↓, 2,   p‑STAT6↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF4↑, 1,   ChrMod↑, 1,   cJun↓, 1,   cJun↑, 1,   cMyc↓, 4,   cMyc↑, 1,   DNMT1↓, 1,   DNMT3B↓, 1,   DNMTs↓, 2,   EZH2↓, 1,   FOXO↑, 2,   FOXO1↑, 1,   H3↓, 1,   p‑H3↓, 1,   H4↓, 1,   HATs↑, 2,   HDAC↓, 10,   HDAC2↓, 1,   HDAC3↓, 1,   miR-106b↓, 1,   miR-124-3p↓, 1,   miR-203↑, 1,   miR-34a↑, 1,   Myc↑, 1,   MYCN↓, 1,   OCT4↓, 2,   other?, 1,   other↑, 2,   other↝, 10,   PhotoS↑, 2,   Prot↓, 1,   sonoS↑, 1,   tumCV↓, 14,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 2,   CHOP/DDIT3↓, 1,   CHOP/DDIT3↑, 5,   eIF2α↑, 2,   p‑eIF2α↑, 1,   ER Stress↑, 7,   GRP78/BiP↑, 3,   GRP94↑, 1,   HSP70/HSPA5↓, 1,   HSP90↓, 2,   IRE1∅, 1,   NQO2↑, 1,   p‑PERK↑, 1,   UPR↑, 3,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 3,   Beclin-1/ATG6↑, 4,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3A↑, 1,   LC3II↑, 5,   LC3s↑, 1,   p62↓, 1,   TumAuto↑, 8,   TumAuto↝, 2,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 1,   DNAdam↓, 1,   DNAdam↑, 18,   DNArepair↓, 1,   ERCC1↓, 1,   P53?, 1,   P53↓, 1,   P53↑, 21,   p‑P53↑, 2,   PARP↑, 5,   cl‑PARP↓, 1,   cl‑PARP↑, 19,   PCNA↓, 10,   Telomerase↓, 3,   TOP1↓, 2,   TOP2↓, 1,   γH2AX↑, 2,  

Cell Cycle & Senescence(tgid=11) ⓘ

CC(CDKs/cyclins)↓, 1,   CDK1↓, 2,   CDK1↑, 1,   CDK2↓, 5,   CDK4↓, 9,   CDK6↓, 2,   CDK6↑, 1,   CHK1↓, 1,   CHK1↑, 1,   Chk2↑, 1,   Cyc↓, 1,   cycA1/CCNA1↓, 1,   CycB/CCNB1↓, 5,   CycB/CCNB1↑, 1,   cycD1/CCND1↓, 17,   cycE/CCNE↓, 4,   E2Fs↓, 1,   GADD34↑, 1,   GADD45A↑, 2,   Ki-67↓, 7,   mitA↑, 1,   P21↓, 1,   P21↑, 14,   p27/CDKN1B↓, 1,   p27/CDKN1B↑, 5,   pRB↓, 1,   p‑pRB↓, 2,   RB1↑, 1,   TumCCA↓, 2,   TumCCA↑, 53,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 1,   BMPs↑, 1,   CD133↓, 1,   CD34↓, 1,   cFos↑, 1,   CSCs?, 1,   CSCs↓, 9,   Diff↑, 2,   FGF↓, 1,   HH↓, 1,   HH↝, 1,   IGF-1↓, 4,   IGFBP3↑, 1,   Ki-67↓, 7,   LRP6↓, 1,   mTORC1↓, 1,   Nanog↓, 1,   Nestin↓, 1,   NOTCH↓, 2,   NOTCH1↓, 7,   OGFr↑, 3,   SCF↓, 1,   Shh↓, 1,   TumCG↓, 27,   TumCG↑, 1,   TumCP↓, 51,   TumCP↑, 3,   Wnt↓, 11,  

Migration(tgid=13) ⓘ

AntiAg↑, 1,   AP-1↓, 2,   AXL↓, 2,   BACH1↓, 1,   CA↓, 1,   Ca+2↓, 1,   Ca+2↑, 9,   Cav1↓, 1,   Cdc42↓, 1,   Cofilin↓, 1,   E-cadherin↓, 2,   E-cadherin↑, 6,   EMT↓, 12,   EpCAM↓, 1,   F-actin↓, 1,   FAK↓, 3,   p‑FAK↓, 2,   fascin↓, 1,   Fibronectin↓, 1,   ITGB1↓, 1,   LAMs↓, 1,   MALAT1↓, 1,   MET↓, 1,   p‑MET↓, 1,   MMP1↓, 1,   MMP13↓, 1,   MMP2↓, 20,   MMP3↓, 2,   MMP7↓, 1,   MMP9↓, 21,   MMPs↓, 12,   N-cadherin↓, 6,   PDGF↓, 2,   Rac1↓, 1,   Rho↓, 2,   ROCK1↓, 1,   Slug↓, 1,   Snail↓, 3,   TGF-β↓, 5,   TGF-β1↓, 1,   TIMP1↑, 5,   TIMP2↑, 2,   TumCI↓, 19,   TumCMig↓, 23,   TumMeta↓, 25,   TumMeta↑, 1,   Twist↓, 3,   Tyro3↓, 1,   uPA↓, 4,   Vim↓, 7,   Vim↑, 1,   Zeb1↓, 2,   β-catenin/ZEB1↓, 13,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 32,   angioG↑, 1,   CD31/PECAM-1↓, 3,   HIF-1↓, 3,   Hif1a↓, 21,   LOX1↓, 1,   VCAM-1↓, 2,   VEGF↓, 30,   VEGFR2/KDR/Flk1↓, 5,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 2,   CellMemb↑, 1,   CLDN1↓, 1,   EPR↑, 2,   GastroP↑, 1,   GLUT1↓, 1,   GLUT2↓, 1,   MMP↓, 30,   NHE1↓, 1,   OATPs↓, 2,   TRPM7↓, 1,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CB2 / CNR2↑, 1,   CD4+↑, 1,   CD44↓, 2,   CD47↓, 1,   CD8+↑, 3,   COX1↓, 1,   COX1↑, 1,   COX2/PTGS2↓, 26,   CXCR4↓, 6,   DCells↑, 1,   HCAR2↑, 1,   HMGB1↓, 2,   ICAM-1↓, 1,   IFN-γ↓, 1,   IFN-γ↑, 1,   IL1↓, 2,   IL10↓, 2,   IL10↑, 1,   IL12↑, 1,   IL1β↓, 10,   IL2↓, 1,   IL2↑, 4,   IL6↓, 15,   IL8↓, 3,   Imm↑, 16,   Imm↝, 1,   INF-γ↑, 1,   INF-γ↝, 1,   Inflam↓, 19,   Inflam↑, 2,   M2 MC↓, 1,   MDSCs↓, 1,   Neut↑, 2,   NF-kB↓, 45,   NF-kB↑, 1,   p‑NF-kB↑, 1,   NK cell↑, 5,   NLRP3↓, 3,   NLRP3↑, 2,   p65↓, 2,   p‑p65↓, 1,   PD-1↓, 2,   PD-L1↓, 4,   PD-L1↑, 1,   PGE2↓, 7,   PGE2↑, 1,   PSA↓, 5,   T-Cell↑, 1,   Th1 response↑, 1,   Th2↑, 1,   TLR4↓, 1,   TNF-α↓, 18,   TNF-α↑, 2,  

Cellular Microenvironment(tgid=17) ⓘ

TAMS↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

BDNF↓, 1,   TrkB↓, 1,  

Protein Aggregation(tgid=19) ⓘ

PSEN1/PS1↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 2,   CYP19↓, 1,   ER-α36↓, 1,   PPARγ↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 1,   BioAv↓, 14,   BioAv↑, 18,   BioAv↝, 4,   chemoR↓, 1,   ChemoSen?, 1,   ChemoSen↑, 106,   ChemoSen⇅, 1,   ChemoSen↝, 1,   ChemoSen∅, 2,   CompStab↓, 2,   CYP1A1↓, 3,   CYP1A1↑, 1,   CYP1A2↓, 1,   CYP3A4↓, 1,   Dose?, 2,   Dose↑, 9,   Dose↝, 43,   Dose∅, 1,   eff↓, 8,   eff↑, 32,   eff⇅, 1,   eff↝, 9,   eff∅, 1,   Half-Life↓, 3,   Half-Life↑, 1,   Half-Life↝, 6,   MDR1↓, 4,   MRP1/ABCC1↓, 2,   P-gp/ABCB1↓, 6,   P450↓, 3,   RadioS↑, 23,   RadioS↝, 1,   selectivity↑, 38,   Synergy↑, 33,  

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 1,   ALAT↓, 4,   ALP↓, 1,   AR↓, 2,   AST↓, 2,   Bil↝, 1,   BUN↓, 3,   CEA↓, 1,   creat↓, 3,   EGFR↓, 8,   EGFR↑, 1,   p‑EGFR↓, 1,   EZH2↓, 1,   HemoG↑, 1,   HER2/EBBR2↓, 1,   IL6↓, 15,   LDH↑, 1,   e-LDH↑, 1,   Myc↑, 1,   NSE↓, 1,   PC↑, 1,   PD-L1↓, 4,   PD-L1↑, 1,   PSA↓, 5,   RBC↑, 3,   Verbal↑, 1,   WBC↑, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiCan↓, 1,   AntiCan↑, 23,   AntiCan∅, 1,   AntiDiabetic↑, 1,   antiNeop↑, 1,   AntiTum↑, 12,   Appetite↑, 2,   BowelM↑, 1,   breath↑, 1,   cachexia↓, 2,   cardioP↑, 10,   chemoP?, 1,   chemoP↓, 3,   chemoP↑, 181,   chemoP↝, 1,   chemoP∅, 1,   chemoPv↑, 5,   ChemoSideEff↓, 4,   cognitive↑, 2,   fatigue↓, 1,   fatigue∅, 1,   hepatoP↑, 17,   hepatoP∅, 1,   memory↑, 1,   Mucositis↓, 1,   Nausea↓, 1,   neuroP↓, 1,   neuroP↑, 7,   NP/CIPN↓, 3,   OS↓, 2,   OS↑, 12,   OS⇅, 1,   Pain↓, 7,   PFS↑, 1,   QoL↑, 20,   QoL∅, 2,   radioP↑, 29,   radioP↝, 1,   Remission↑, 1,   RenoP↑, 9,   RenoP∅, 1,   Risk↓, 19,   Risk↑, 2,   Risk⇅, 1,   Sleep↑, 2,   Strength↑, 2,   toxicity↓, 11,   toxicity↑, 1,   toxicity↝, 4,   toxicity∅, 2,   TumVol?, 1,   TumVol↓, 10,   TumVol↑, 1,   TumW↓, 1,   Weight↑, 5,   Weight∅, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↓, 1,   GutMicro↑, 4,   Sepsis↓, 2,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 1,  
Total Targets: 608

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 4,   antiOx↑, 60,   ARE↑, 1,   Catalase↑, 24,   Copper↓, 1,   Fenton↓, 2,   GPx↑, 23,   GPx1↑, 1,   GPx4↓, 1,   GPx4↑, 1,   GSH↑, 28,   GSR↑, 4,   GSTs↑, 9,   H2O2↓, 1,   HDL↑, 2,   HO-1↓, 2,   HO-1↑, 21,   Iron↓, 2,   Iron↑, 1,   Keap1↓, 2,   Keap1↝, 1,   lipid-P↓, 18,   MDA↓, 18,   MDA↑, 1,   MPO↓, 6,   MPO↑, 2,   NADH↓, 1,   NOX↓, 1,   NOX4↓, 2,   NQO1↑, 3,   NRF2↑, 39,   RNS↓, 3,   ROS↓, 67,   ROS↝, 1,   ROS∅, 2,   mt-ROS?, 1,   SAM-e↑, 1,   selenoP↑, 2,   SOD↑, 34,   SOD1↑, 3,   SOD2↑, 2,   TAC↑, 1,   TBARS↓, 2,   VitE↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compI↑, 1,   compII↑, 1,   compIII↑, 1,   DRP1/DNM1L↓, 1,   FIS1↓, 1,   Insulin↓, 1,   Insulin↑, 1,   MFN2↑, 2,   mtDam↓, 1,   PGC-1α↑, 2,   PGC-1α↝, 1,   PINK1↑, 1,   SIRT3↑, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

15-LOX/ALOX15↓, 1,   5LO↓, 1,   ACC↓, 1,   Acetyl-CoA↓, 1,   adiP↑, 1,   ALAT↓, 9,   AMPK↑, 5,   ATP↑, 4,   ATP↝, 1,   CRM↓, 1,   FABP4↓, 1,   FASN↓, 1,   FFA/NEFA↓, 1,   glucose↓, 4,   glucose↝, 1,   GlucoseCon↑, 1,   GSK‐3β↑, 1,   H2S↑, 1,   KeyT↝, 1,   LDL↓, 4,   NAD↝, 1,   NADPH↓, 4,   NADPH↑, 1,   PLA2↓, 1,   SIRT1↑, 4,   SREBF2⇅, 1,  

Cell Death(tgid=5) ⓘ

AIF↓, 1,   Apoptosis↓, 10,   ASK1↓, 1,   BAX↓, 1,   Bax:Bcl2↓, 1,   Bcl-2↑, 2,   Bcl-xL↑, 1,   Casp12↓, 1,   Casp3↓, 12,   cl‑Casp8↑, 1,   Casp9↓, 5,   Cyt‑c↓, 1,   Fas↓, 1,   FasL↓, 1,   Ferroptosis↓, 2,   GranB/GZMB↓, 1,   iNOS↓, 8,   necrosis↓, 1,   p38↓, 2,   p‑p38↓, 1,   TUNEL↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 2,   Akt↑, 5,   Akt↝, 1,   AMPKα↑, 1,   ERK↓, 2,   IGF-1R↓, 1,   IKKα↑, 1,   IκB?, 1,   JAK↓, 1,   JAK2↑, 1,   JNK↓, 1,   p‑JNK↓, 2,   MAPK↓, 2,   MAPK↑, 1,   MAPK↝, 1,   mTOR↓, 3,   p‑mTOR↓, 1,   PDGFR-BB↓, 1,   PI3K↓, 2,   PI3K↑, 2,   PKCδ?, 1,   PKCδ↓, 1,   PTEN↓, 1,   STAT3↓, 1,   STAT3↑, 1,   STAT3↝, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 4,   ATF2↑, 1,   ATF4↓, 1,   FOXO3↑, 1,   HDAC↑, 1,   miR-34a↓, 1,   other?, 2,   other↓, 5,   other↑, 10,   other↝, 2,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 2,   p‑eIF2α↓, 1,   ER Stress↓, 3,   GRP78/BiP↓, 2,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↑, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3II↑, 1,   MitoP↓, 1,   p62↑, 1,   PARK2↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 4,   DNArepair↑, 1,   P53↓, 3,   P53↑, 1,   PARP1↓, 1,   PCNA↑, 1,   SIRT6↑, 1,   Telomerase↓, 1,   TOP1↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

E2Fs↑, 1,   GADD45A↑, 1,   P21↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMPs↑, 1,   CEBPA↓, 1,   EP2↓, 1,   HH↓, 1,   IGF-1↑, 1,   mTORC1↓, 1,   neuroG↑, 1,   p300↓, 1,   TumCP↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↓, 2,   AntiAg↑, 5,   AP-1↓, 3,   Ca+2↓, 1,   Ca+2↝, 2,   Cartilage↑, 1,   COL1↓, 1,   E-cadherin↑, 1,   EMT↓, 1,   MMP13↓, 1,   MMP2↓, 1,   MMPs↓, 1,   p‑Rac1↓, 1,   serineP↓, 1,   TGF-β↓, 1,   TGF-β↑, 2,   TGF-β1↓, 1,   TIMP1↓, 1,   TumCI↓, 1,   TumCMig↓, 1,   uPA↑, 1,   Vim↓, 1,   α-SMA↓, 1,   α-SMA↝, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   Hif1a↑, 1,   NO↓, 5,   VCAM-1↓, 2,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 5,   BBB∅, 1,   GastroP↑, 1,   GLUT4↑, 1,   H+/K+-ATPase↓, 1,   IBI↑, 1,   memfluid↑, 1,   MMP↑, 5,   TRPM7↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD25+↑, 1,   CD4+↑, 2,   CD8+↑, 1,   COX1↓, 3,   COX2/PTGS2↓, 15,   COX2/PTGS2↑, 1,   FOXP3↑, 1,   HMGB1↓, 2,   IFN-γ↓, 2,   IL10↓, 4,   IL10↑, 5,   IL17↓, 1,   IL18↓, 1,   IL1β↓, 13,   IL2↓, 1,   IL4↓, 3,   IL4↑, 2,   IL6↓, 23,   IL8↓, 2,   Imm↑, 6,   Imm↝, 1,   Inflam↓, 64,   LPS↓, 2,   M2 MC↑, 2,   pol-M2 MC↑, 1,   MCP1/CCL2↓, 3,   MyD88↓, 1,   NF-kB↓, 20,   NLRP3↓, 4,   PGE2↓, 7,   TLR4↓, 3,   TNF-α↓, 27,   Treg lymp↝, 1,   TRIF↓, 1,   VitD↑, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   5HT↑, 1,   AChE↓, 4,   BChE↓, 2,   BDNF↑, 2,   MAOA↓, 1,   MAOB↓, 1,   NGF↑, 1,   TrkB↑, 1,   β-Endo↑, 1,  

Protein Aggregation(tgid=19) ⓘ

APP↓, 1,   Aβ↓, 2,   BACE/β-secretase↓, 1,   p‑tau↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 1,   ACE2↓, 1,   BNP↓, 1,   NR1H4↑, 1,   PPARγ↓, 1,   testos↑, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 19,   BioAv↑, 21,   BioAv↝, 14,   BioEnh↑, 2,   ChemoSen↑, 1,   CYP3A2↓, 1,   Dose?, 3,   Dose↓, 2,   Dose↑, 2,   Dose↝, 14,   eff↑, 9,   GSTA1↑, 2,   Half-Life↓, 3,   Half-Life↑, 1,   Half-Life↝, 8,   P-gp/ABCB1↓, 2,   selectivity↑, 3,   Synergy↑, 7,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 9,   ALB↝, 1,   ALP↓, 3,   AST↓, 12,   BloodF↑, 1,   BMD↑, 3,   BP↓, 4,   BUN?, 1,   BUN↓, 4,   Calcium↑, 1,   creat↓, 9,   hs-CRP↓, 1,   IL6↓, 23,   IRes↝, 1,   KeyT↝, 1,   LDH↓, 4,   Mag↑, 1,   NOS2↓, 1,   SpO2↑, 1,   TC↓, 1,   TG/TAG↓, 1,   TMAO↓, 1,   Urea↓, 2,   VitD↑, 1,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 1,   AntiAge↑, 5,   antiAll↑, 8,   AntiArt↑, 1,   AntiCan↑, 10,   AntiDiabetic↓, 1,   AntiDiabetic↑, 11,   antiPs↑, 2,   AntiTum↓, 1,   AntiTum↑, 3,   cardioP?, 2,   cardioP↑, 25,   chemoP↑, 46,   chemoPv↑, 3,   ChemoSideEff↓, 1,   cognitive↓, 1,   cognitive↑, 11,   cough?, 1,   hepatoP↓, 1,   hepatoP↑, 25,   memory↑, 5,   motorD↑, 1,   Mucositis↓, 1,   neuroP↓, 1,   neuroP↑, 28,   Obesity↓, 8,   OS↑, 4,   Pain↓, 4,   QoL↑, 1,   radioP↑, 8,   RenoP↑, 15,   Risk↓, 1,   SoreThr?, 1,   Strength↑, 1,   Stress↓, 1,   Stroke↓, 5,   toxicity↓, 24,   toxicity↑, 1,   toxicity↝, 9,   toxicity∅, 1,   Weight↓, 1,   Weight↑, 1,   Wound Healing↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 4,   AntiFungal↑, 3,   AntiViral↑, 5,   Bacteria↓, 8,   Diar↓, 1,   GutMicro↑, 9,   Sepsis↓, 3,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↑, 2,   Ingr↝, 2,  
Total Targets: 360

Scientific Paper Hit Count for: chemoP, ChemoProtective
21 Chemotherapy
14 Cisplatin
11 Silymarin (Milk Thistle) silibinin
10 Hydrogen Gas
9 Selenium
8 doxorubicin
8 Selenite (Sodium)
7 Curcumin
7 Thymoquinone
6 Melatonin
5 Allicin (mainly Garlic)
5 Anti-oxidants
5 Radiotherapy/Radiation
5 phytic acid, Inositol hexakisphosphate
4 Astragalus
4 Quercetin
4 Fucoidan
4 Honokiol
4 Inositol
4 Licorice
4 Luteolin
4 Lycopene
4 Morin
3 Ashwagandha(Withaferin A)
3 Astaxanthin
3 Paclitaxel/Taxol
3 Coenzyme Q10
3 EGCG (Epigallocatechin Gallate)
3 diet Short Term Fasting
3 Dandelion Root
3 HydroxyTyrosol
3 isoorientin
3 Licochalcone A
3 low dose naltrexone
3 Linalool
3 Magnetic Fields
3 Urolithin
2 Alpha-Lipoic-Acid
2 Apigenin (mainly Parsley)
2 beta-glucans
2 Brucea javanica
2 brusatol
2 Boron
2 Butyrate
2 Propolis -bee glue
2 Carvacrol
2 Thymol-Thymus vulgaris
2 Chrysin
2 Garcinol
2 Docosahexaenoic Acid
2 Ellagic acid
2 Fisetin
2 Flaxseed/Linseed
2 Shilajit/Fulvic Acid
2 iodine
2 5-fluorouracil
2 Metformin
2 Oleuropein
2 Rosmarinic acid
2 Rutin
2 Selenium NanoParticles
1 Silver-NanoParticles
1 Anzaroot, Astragalus fasciculifolius Bioss
1 Anethole/trans-Anethole
1 Atorvastatin
1 immunotherapy
1 Baicalein
1 Berberine
1 Gold NanoParticles
1 Beta-Caryophyllene
1 Betulinic acid
1 Bromelain
1 α-Bisabolol / Chamomile oil
1 Carnosic acid
1 Caffeic Acid Phenethyl Ester (CAPE)
1 Cat’s Claw
1 Chlorogenic acid
1 Chlorophyllin
1 Chocolate
1 Vitamin E
1 Calorie Restriction Mimetics
1 HydroxyCitric Acid
1 Crocetin
1 diet Plant based
1 Diindolylmethane
1 Indole-3-carbinol
1 Lemongrass Extract/Citral
1 Disulfiram
1 Copper and Cu NanoParticles
1 Echinacea
1 Docetaxel
1 Emodin
1 Eugenol
1 Exercise
1 Formononetin
1 carboplatin
1 Gallic acid
1 Ginkgetin
1 γ-linolenic acid (Borage Oil)
1 Hyperoside
1 MCT, metronomic chemo
1 Isoliquiritigenin
1 isoflavones
1 isoquercitrin
1 Kaempferol
1 Lactoferrin/Talactoferrin
1 SDG/lignans
1 Magnolol
1 Matrine
1 Magnetic Field Rotating
1 Moringa oleifera
1 Methylsulfonylmethane
1 Naringin
1 Aidi injection
1 Phenylbutyrate
1 Phenethyl isothiocyanate
1 Piperine
1 Psoralidin
1 benzo(a)pyrene
1 buckwheat sprouts
1 irinotecan
1 Sulforaphane (mainly Broccoli)
1 Shikonin
1 Squalene
1 Vitexin
1 Isovitexin
1 Zerumbone
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1171  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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