hepatoP Cancer Research Results

hepatoP, L,hepatoprotective: Click to Expand ⟱
Source:
Type:
Hepatoprotective is the ability of a chemical substance to prevent damage to the liver.

Grapefruit:
-hepatoprotective potential has emerged from the study of naringenin and naringin.
Blueberries/cranberries:
-proanthocyanidins
Grape:
Nopal (Cactus pear) and tuna (Cactus pear fruit) “Opuntia ficus-indica”:
Chamomile (Matricaria chamomilla or Chamomilla recutita):
Silymarin (Silybum marianum):
Blue green algae spirulina :
Propolis (bee glue):

POLYSACCHARIDES
β-glucans
Scientific Papers found: Click to Expand⟱
3517- Bor,  Se,    The protective effects of selenium and boron on cyclophosphamide-induced hepatic oxidative stress, inflammation, and apoptosis in rats
- in-vivo, Nor, NA
*hepatoP↑, *ALAT↓, *AST↓, *ALP↓, *NF-kB↓, *TNF-α↓, *IL1β↓, *IL6↓, *IL10↑, *SOD↑, *Catalase↑, *MDA↓, *GSH↑, *GPx↑, *antiOx↑, *NRF2↑, *Keap1↓,
3520- Bor,    Effect of boron element on photoaging in rats
- in-vivo, Nor, NA
*hepatoP↑, *BMD↑, *COX2/PTGS2↓, *IL8↓, *NF-kB↓, *IL6↓, *TNF-α↓,
3516- Bor,    Boron in wound healing: a comprehensive investigation of its diverse mechanisms
- Review, Wounds, NA
*Inflam↓, *antiOx↑, *ROS↓, *angioG↑, *COL1↑, *α-SMA↑, *TGF-β↑, *BMD↑, *hepatoP↑, *TNF-α↑, *HSP70/HSPA5↑, *SOD↑, *Catalase↑, *GSH↑, *MDA↓, *TOS↓, *IL6↓, *JAK2↓, *STAT3↓, *AMPK↑, *lipid-P↓, *VEGF↑, *Half-Life↝,
2775- Bos,    The journey of boswellic acids from synthesis to pharmacological activities
- Review, Var, NA - Review, AD, NA - Review, PSA, NA
ROS↑, ER Stress↑, TumCG↓, Apoptosis↑, Inflam↓, ChemoSen↑, Casp↑, ERK↓, cl‑PARP↑, AR↓, cycD1/CCND1↓, VEGFR2/KDR/Flk1↓, CXCR4↓, radioP↑, NF-kB↓, VEGF↓, P21↑, Wnt↓, β-catenin/ZEB1↓, Cyt‑c↑, MMP2↓, MMP1↓, MMP9↓, PI3K↓, MAPK↓, JNK↑, *5LO↓, *NRF2↑, *HO-1↑, *MDA↓, *SOD↑, *hepatoP↑, *ALAT↓, *AST↓, *LDH↑, *CRP↓, *COX2/PTGS2↓, *GSH↑, *ROS↓, *Imm↑, *Dose↝, *eff↑, *neuroP↑, *cognitive↑, *IL6↓, *TNF-α↓, *AntiArt↑, *AntiDiabetic↑, *antiAll↑,
6556- BSB,    A Comprehensive Study of Therapeutic Applications of Chamomile
- Review, Nor, NA - Review, AD, NA - Review, Park, NA - Review, Stroke, NA
*Inflam↓, *antiOx↑, *AntiBio↑, *hepatoP↑, *AntiCan↑, *other↝, *toxicity↓, *Wound Healing↓, *Dose↝, *Dose↝, *eff↝, *ROS↓, *TNF-α↓, *IL6↓, *other↝, *AST↓, *ALAT↓, *antiAll↑,
7953- BuckWS,  RT,    Review of the protective effects of rutin on the metabolic function as an important dietary flavonoid
- Review, Nor, NA
*GastroP↑, *hepatoP↑, *AntiDiabetic↑, *Inflam↓, *BioAv↓, *LDL↓, *Fenton↓, *AGEs↓, *GSH↑, *Dose↝,
7947- BuckWS,    Anti-inflammatory effect of buckwheat sprouts in lipopolysaccharide-activated human colon cancer cells and mice
- vitro+vivo, Colon, NA
Inflam↓, *hepatoP↑,
5881- CAR,    Carvacrol—A Natural Phenolic Compound with Antimicrobial Properties
- Review, Nor, NA
*Bacteria↓, *Inflam↓, *SOD↑, *GPx↑, *GSR↑, *Catalase↑, *toxicity↓, *Pain↓, *other↑, *cardioP↑, *RenoP↑, *neuroP↑, *antiOx↑, *AntiDiabetic↑, *hepatoP↑, *Obesity↓, *AntiAg↑, *BioAv↓, BioAv↝, *OS↑, MMP↓, ROS↑, *MDA↓, *lipid-P↓, *COX2/PTGS2↓, *Dose↝,
5888- CAR,    Therapeutic application of carvacrol: A comprehensive review
- Review, Var, NA - Review, Stroke, NA - Review, Diabetic, NA - Review, Park, NA
*antiOx↑, *AntiCan↑, *AntiDiabetic↑, *cardioP↑, *Obesity↓, *hepatoP↑, *AntiAg↑, *Bacteria↓, *Imm↑, MMP2↓, MMP9↓, Apoptosis↓, MMP↓, ERK↓, PI3K↓, ALAT↓, *ROS↓, *Catalase↑, *SOD↑, *GPx↑, *AST↓, *LDH↓, *necrosis↓, ROS↑, TumCCA↑, CDK4↓, cycD1/CCND1↓, NOTCH↓, IL6↓, chemoP↑, *Pain↓, *neuroP↑, *TRPM7↓, *motorD↑, *NF-kB↓, *COX2/PTGS2↓, *MDA↓,
5909- CAR,    Potential preventive effect of carvacrol against diethylnitrosamine-induced hepatocellular carcinoma in rats
- in-vivo, HCC, NA
*AST↓, *ALAT↓, *ALP↓, *LDH↓, *SOD↑, *Catalase↑, *GSH↑, *GPx↑, *GSR↑, *hepatoP↑, *lipid-P↓,
5898- CAR,    Carvacrol-induced apoptosis via tumor suppressor gene activation and oxidative stress modulation in a rat model of breast cancer
- in-vivo, BC, NA
*lipid-P↓, *MDA↓, *antiOx↑, *Inflam↑, RenoP↑, hepatoP↑, *ALAT↓, AST↓, creat↓, chemoPv↑, Cyt‑c↑, FADD↑, P53↑,
5894- CAR,    Targeting Gastrointestinal Cancers with Carvacrol: Mechanistic Insights and Therapeutic Potential
- Review, Var, NA
AntiCan↑, Apoptosis↑, Inflam↓, angioG↓, TumMeta↓, selectivity↑, BioAv↑, ChemoSen↑, Dose↝, TumCP↓, hepatoP↑, Casp3↑, Casp9↑, Bcl-2↓, ROS↑, GSH↓, BAX↑, Casp7↑, Casp8↑, Cyt‑c↑, Fas↑, FADD↑, P53↑, Bcl-2↓, TumMeta↓, TumCMig↓, TumCI↓, E-cadherin↑, TIMP2↑, TIMP3↑, N-cadherin↓, ZEB2↓, *lipid-P↓, *AST↓, *ALAT↓, *ALP↓, *LDH↓, *SOD↑, *Catalase↑, *GPx↑, *GSR↑, selectivity↑, cl‑PARP↑, ERK↓, p38↑, OS↑, AFP↓, COX2/PTGS2↓, VEGF↓, PCNA↓, Ki-67↓, TNF-α↓, BioAv↓,
5893- CAR,  TV,    Thymol and Carvacrol: Molecular Mechanisms, Therapeutic Potential, and Synergy With Conventional Therapies in Cancer Management
- Review, Var, NA
*Inflam↓, AntiCan↑, PI3K↓, Akt↓, mTOR↓, NOTCH↓, PIK3CA↓, EGFR↓, Hif1a↓, VEGF↓, ChemoSen↑, RadioS↑, eff↝, *cardioP↑, *neuroP↑, *hepatoP↑, Apoptosis↑, MMP↓, Casp3↑, ROS↑, DNAdam↑, eff↑, BAX↑, BAD↑, FasL↑, Cyt‑c↑, Casp9↑, Casp8↑, TumCCA↑, P21↑, Smo↓, Gli1↓, JNK↑, ERK↓, MAPK↓, TRPM7↓, Wnt/(β-catenin)↓, CompStab↝, CompStab↑,
5892- CAR,  SRF,    Carvacrol potentiates immunity and sorafenib anti-cancer efficacy by targeting HIF-1α/STAT3/ FGL1 pathway: in silico and in vivo study
- in-vivo, HCC, NA
Hif1a↓, AFP↑, hepatoP↑, STAT3↓, JAK2↓, *CD8+↑, ChemoSen↑, Dose↝, angioG↓,
5891- CAR,  SRF,    Carvacrol enhances anti-tumor activity and mitigates cardiotoxicity of sorafenib in thioacetamide-induced hepatocellular carcinoma model through inhibiting TRPM7
- in-vivo, HCC, NA
Synergy↑, OS↑, hepatoP↑, AFP↓, NOTCH↓, cycD1/CCND1↓, Bcl-xL↑, Casp3↑, TRPM7↓, Dose↝,
5926- CAR,    An Updated Review of Research into Carvacrol and Its Biological Activities
- Review, Nor, NA - Review, AD, NA - Review, Asthma, NA
*Inflam↓, *antiOx↑, *neuroP↑, *BioAv↑, *toxicity↓, *Pain↓, *TRPV3↑, *NRF2↑, *Ca+2↑, *ATP↑, *5LO↓, *COX2/PTGS2↓, PGE2↓, *hepatoP↑, *AntiAg↑, *Diar↓, *cardioP↑, *other↝, *chemoPv↑, *cognitive↑, *AChE↓, *GastroP↑, *Synergy↑, *BChE↓, *CRP↓, *antiAll↑,
6254- CBC/D,    Cynanchum auriculatum Royle ex Wight., Cynanchum bungei Decne. and Cynanchum wilfordii (Maxim.) Hemsl.: Current Research and Prospects
- Review, Var, NA
*neuroP↑, *Imm↑, *Inflam↓, CSCs↓, HH↓, Gli↓, AST↓, ALAT↓, MDA↓, hepatoP↑, *NRF2↑, *HO-1↑, NF-kB?, GSK‐3β↓, β-catenin/ZEB1↓, COX2/PTGS2↓, MMP2↑, MMP9↓, BioAv↑,
5948- Cela,    Recent Trends in anti-tumor mechanisms and molecular targets of celastrol
- Review, Var, NA
TumCP↓, TumCCA↑, Apoptosis↑, TumAuto↑, TumCI↓, TumMeta↓, Imm↝, angioG↓, Cyt‑c↑, ROS↑, BAX↑, Casp3↑, Casp9↑, cl‑PARP↑, PrxII↓, ER Stress↑, mtDam↑, CHOP/DDIT3↑, Inflam↓, NF-kB↓, CXCR4↓, MMP9↓, IL6↓, TNF-α↓, HSP90↓, neuroP↑, STAT3↓, Prx↓, HO-1↑, eff↑, eff↑, BioAv↑, toxicity↑, CardioT↑, hepatoP↓,
6660- Cen,    Hepatoprotective effect of Centella asiatica 50% ethanol extract against acetaminophen-induced acute liver injury in BALB/c mice
- in-vivo, LiverDam, NA
*hepatoP↑, *NO↓, *lipid-P↓, *IL1β↓, *ALAT↓, *AST↓, *LDH↓, GSH↑, MDA↓,
6658- Cen,    A Comparative Study of the Hepatoprotective Effect of Centella asiatica Extract (CA-HE50) on Lipopolysaccharide/d-galactosamine-Induced Acute Liver Injury in C57BL/6 Mice
- in-vivo, Nor, NA
*hepatoP↑,
6656- Cen,    Recent insights into therapeutic potential and nanostructured carrier systems of Centella asiatica: An evidence-based review
- Review, Var, NA - Review, AD, NA
AntiCan↑, *AntiDiabetic↑, *neuroP↑, *antiOx↑, *cardioP↑, *Inflam↓, *hepatoP↑, *AntiAge↑, *AST↓, *ALAT↓, *LDH↓, *lipid-P↓, Casp3↑, *memory↑, *Wound Healing↑, eff↑,
6648- Cen,    Centella asiatica (L.) Urban: From Traditional Medicine to Modern Medicine with Neuroprotective Potential
- Review, AD, NA
*neuroP↑, *Aβ↓, *ROS↓, *Wound Healing↑, *memory↑, *Inflam↓, *hepatoP↑, *Imm↑, *cardioP↑, *AntiDiabetic↑, *AntiFungal↑, *antiOx↑, *Dose↝, *AChE↓, *BChE↓, *Tyro3↓, *lipid-P↓,
6021- CGA,    Chlorogenic acid for cancer prevention and therapy: Current status on efficacy and mechanisms of action
- in-vitro, Var, NA
*hepatoP↑, *Bacteria↓, *Imm↑, *antiOx↑, *AntiDiabetic↓, *AntiCan↑, TumCCA↑, Apoptosis↑, TumCP↓,
6002- CGA,    Chlorogenic Acid: A Systematic Review on the Biological Functions, Mechanistic Actions, and Therapeutic Potentials
- Review, Var, NA - Review, Diabetic, NA - Review, AD, NA - Review, Park, NA - Review, Stroke, NA
*neuroP↑, *Inflam↓, *antiOx↑, *cardioP↑, *NRF2↑, *AMPK↑, *SOD↑, *Catalase↑, *GSH↑, *GPx↑, *ROS↓, *TNF-α↓, *IL6↓, *NF-kB↓, *COX2/PTGS2↓, *glucose↓, *TRPC1↓, *Ca+2↓, *HO-1↑, *NF-kB↓, *PPARα↝, *Hif1a↓, *JNK↓, *BP↓, *AntiDiabetic↑, *hepatoP↑, *TLR4↓, *NRF2↑, *Casp↓, *neuroP↑, *Aβ↓, *LDH↓, *MDA↓, *memory↑, *AChE↓, *Stroke↓, EMT↝, N-cadherin↓, E-cadherin↑, TumCCA↑, ROS↑, p‑P53↑, HO-1↑, NRF2↑, ChemoSen↑, mtDam↑, Casp3↑, Casp9↑, PARP↑, Bax:Bcl2↑, TumCG↓, cycD1/CCND1↓, cMyc↓, CDK2↓, mitResp↓, Glycolysis↓, Hif1a↓, PCNA↓, p‑GSK‐3β↓, VEGF↓, PI3K↓, Akt↓, mTOR↓, OS↑,
6010- CGA,    The Biological Activity Mechanism of Chlorogenic Acid and Its Applications in Food Industry: A Review
- Review, Nor, NA
*antiOx↑, *hepatoP↑, *RenoP↑, AntiTum↑, *glucose↝, *Inflam↓, *neuroP↑, *ROS↓, *Keap1↓, *NRF2↑, *SOD↑, *Catalase↑, *GPx↑, *GSH↑, *MDA↓, *p‑ERK↑, *GRP78/BiP↑, *CHOP/DDIT3↑, *GRP94↑, *Casp3↓, *Casp9↓, *HGF/c-Met↑, *TNF-α↓, *TLR4↓, *MAPK↓, *IL1β↓, *iNOS↓, TCA↓, Glycolysis↓, Bcl-2↓, BAX↑, MAPK↑, JNK↑, CSCs↓, Nanog↓, SOX2↓, CD44↓, OCT4↓, P53↑, P21↑, *SOD1↑, *AGEs↓, *GLUT2↑, *HDL↑, *Fas↓, *HMG-CoA↓, *NF-kB↓, *HO-1↓, *COX2/PTGS2↓, *TLR4↓, *BioAv↑, *BioAv↝, TumCP↓, TumCMig↓, TumCI↓,
6011- CGA,    Chlorogenic Acid’s Role in Metabolic Health: Mechanisms and Therapeutic Potential
- Review, Nor, NA
*BioAv↓, *antiOx↑, *Inflam↓, *Bacteria↓, *hepatoP↑, *cardioP↑, *neuroP↑, *ROS↓, *NF-kB↓, *NRF2↑, *Obesity↓, *GutMicro↑, *AntiAg↑, *cardioP↑, *AntiDiabetic↑, *NLRP3↓, *OCLN↓, *VEGF↓, BioAv↝,
6014- CGA,    Exploring the Pharmacological Potential of Chlorogenic acid as an Anti-Cancer Agent and a Call for Advance Research
- Review, Var, NA
AntiCan↑, *hepatoP↑, *Bacteria↓, *antiOx↓, *AntiDiabetic↑, Apoptosis↓, TumCG↓, angioG↓, TumCI↓, TumCMig↓, ROS↝, Inflam↝,
6023- CGA,    Pharmacological advances of the chlorogenic acids family: current insights and future research directions
- Review, AD, NA - Review, Park, NA - Review, IBD, NA
*Aβ↓, *neuroP↑, *cardioP↑, *GastroP↑, *RenoP↑, *hepatoP↑, *Obesity↓, *Bacteria↓, *BioAv↑, *BioAv↑, *BioAv↑, *ROS↓, *GutMicro↑, *IBI↑, *MCT1↓, *NF-kB↓, *DNMT1↓,
6080- CHL,  VitC,    Protective Effects of Sodium Copper Chlorophyllin and/or Ascorbic Acid Against Barium Chloride-Induced Oxidative Stress in Mouse Brain and Liver
- in-vivo, Nor, NA
*neuroP↑, *MDA↓, *hepatoP↑, *IronCh↑, *ROS↓, *lipid-P↓,
6105- Chol,    Choline supplementation protects against liver damage by normalizing cholesterol metabolism in Pemt/Ldlr knockout mice fed a high-fat diet
- in-vivo, Nor, NA
*hepatoP↑,
6135- CHr,    Chrysin as a Multifunctional Therapeutic Flavonoid: Emerging Insights in Pathogenesis Management: A Narrative Review
- Review, Var, NA - Review, AD, NA
Inflam↓, angioG↓, Apoptosis↑, TumAuto↑, TumCCA↑, BioAv↓, Half-Life↓, BioAv↓, *ROS↓, *hepatoP↑, *RenoP↑, TET1↑, MMP9↓, cMyc↓, Ki-67↓, CBR1↓, ROS↑, ChemoSen↑, Bax:Bcl2↑, PUMA↑, NOTCH1↑, *AntiDiabetic↑, *neuroP↑, *GABA↑, *DNAdam↓, *BDNF↑, *memory↑, *AGEs↓, *Aβ↓, *cardioP↑, *AntiArt↑, Synergy↑, Synergy↑, *Synergy↑, RadioS↑, Synergy↑, ChemoSen↑, eff↑,
2780- CHr,    Anti-cancer Activity of Chrysin in Cancer Therapy: a Systematic Review
- Review, Var, NA
*antiOx↑, Inflam↓, *hepatoP↑, AntiCan↑, Cyt‑c↑, Casp3↑, XIAP↓, p‑Akt↓, PI3K↑, Apoptosis↑, COX2/PTGS2↓, FAK↓, AMPK↑, STAT3↑, MMP↓, DNAdam↑, BAX↑, Bak↑, Casp9↑, p38↑, MAPK↑, TumCCA↑, ChemoSen↑, HDAC8↓, Wnt↓, NF-kB↓, angioG↓, BioAv↓, *antiAll↑,
2781- CHr,  PBG,    Chrysin a promising anticancer agent: recent perspectives
- Review, Var, NA
PI3K↓, Akt↓, mTOR↓, MMP9↑, uPA↓, VEGF↓, AR↓, Casp↑, TumMeta↓, TumCCA↑, angioG↓, BioAv↓, *hepatoP↑, *neuroP↑, *SOD↑, *GPx↑, *ROS↓, *Inflam↓, *Catalase↑, *MDA↓, ROS↓, BBB↑, Half-Life↓, BioAv↑, ROS↑, Synergy↑, ROS↑, ROS↑, lipid-P↑, ER Stress↑, NOTCH1↑, NRF2↓, p‑FAK↓, Rho↓, PCNA↓, COX2/PTGS2↓, NF-kB↓, PDK1 / PDPK1↓, PDK3↑, GLUT1↓, Glycolysis↓, mt-ATP↓, Ki-67↓, cMyc↓, ROCK1↓, TOP1↓, TNF-α↓, IL1β↓, CycB/CCNB1↓, CDK2↓, EMT↓, STAT3↓, PD-L1↓, IL2↑,
2782- CHr,    Broad-Spectrum Preclinical Antitumor Activity of Chrysin: Current Trends and Future Perspectives
- Review, Var, NA - Review, Stroke, NA - Review, Park, NA
*antiOx↑, *Inflam↓, *hepatoP↑, *neuroP↑, *BioAv↓, *cardioP↑, *lipidLev↓, *RenoP↑, *TNF-α↓, *IL2↓, *PI3K↓, *Akt↓, *ROS↓, *cognitive↑, Synergy↑, cycD1/CCND1↓, hTERT/TERT↓, VEGF↓, p‑STAT3↓, TumMeta↓, TumCP↓, Synergy↑, Synergy↑, IL1β↓, IL6↓, NF-kB↓, ROS↑, MMP↓, Cyt‑c↑, Apoptosis↑, ER Stress↑, Ca+2↑, TET1↑, Let-7↑, Twist↓, EMT↓, TumCCA↑, Casp3↑, Casp9↑, BAX↑, HK2↓, GlucoseCon↓, lactateProd↓, Glycolysis↓, SHP1↑, N-cadherin↓, E-cadherin↑, UPR↑, PERK↑, ATF4↑, eIF2α↑, RadioS↑, NOTCH1↑, NRF2↓, BioAv↑, Synergy↑,
2788- CHr,    Chrysin: Sources, beneficial pharmacological activities, and molecular mechanism of action
- Review, Var, NA
*neuroP↑, *Inflam↓, *ROS↓, NF-kB↓, *PCNA↓, *COX2/PTGS2↓, ChemoSen↑, Hif1a↓, angioG↓, *chemoPv↑, PDGF↓, *memory↑, *RenoP↑, *PPARα↑, *lipidLev↓, *hepatoP↑, *cardioP⇅, *BioAv↓,
2790- CHr,    Chrysin: Pharmacological and therapeutic properties
- Review, Var, NA
*hepatoP↑, *neuroP↓, *ROS↓, *cardioP↑, *Inflam↓, Synergy↑, hTERT/TERT↓, cycD1/CCND1↓, MMP9↓, MMP2↓, TIMP1↑, TIMP2↑, BioAv↑, HK2↓, ROS↑, MMP↓, Casp3↑, ADP:ATP↑, Apoptosis↑, ER Stress↑, UPR↑, GRP78/BiP↝, Synergy↑, Ca+2↑,
7406- Chy,    Antiamnesic activity of an ayurvedic formulation chyawanprash in mice
- in-vivo, AD, NA
*Dose↝, *memory↑, *TBARS↓, *GSH↑, *ROS↓, *cognitive↑, *AntiAge↑, *hepatoP↑, *antiOx↑, *LDL↓, *Inflam↓, *other↝, *AChE∅,
6623- Cic,  MTX,    Chicoric acid prevents methotrexate hepatotoxicity via attenuation of oxidative stress and inflammation and up-regulation of PPARγ and Nrf2/HO-1 signaling
- in-vivo, Nor, NA
*antiOx↑, *hepatoP↑, *ROS↓, *lipid-P↓, *TAC↑, *NRF2↑, *HO-1↑, *NQO1↑, *PPARγ↑, *Inflam↓, *Apoptosis↓, *Bcl-2↑, *BAX↓, *Cyt‑c↓, *Casp3↓,
6140- Cin,  HCAs,    Cinnamaldehyde: Pharmacokinetics, anticancer properties and therapeutic potential (Review)
- Review, Var, NA
Dose↝, TumCP↓, TumCCA↑, Apoptosis↑, TumCMig↓, TumCI↓, angioG↓, *Inflam↓, *antiOx↑, *Bacteria↓, *AntiThr↑, *hepatoP↑, *AntiDiabetic↑, *neuroP↑, AntiCan↑, ChemoSen↑, *BioAv↝, *BioAv↑, Synergy↑, CDK1↓, CDK2↓, CDK4↓, cJun↓, cFos↓, Apoptosis↑, PI3K↓, Akt↓, E-cadherin↑, MMP2↓, MMP9↓, TOP1↓, BRCA1↓, ROS↑, BAX↑, Bcl-2↓, XIAP↓, MMP↓, STAT3↓, mTOR↓, NF-kB↓, eff↑, toxicity↓, cardioP↑,
4767- CoQ10,    Efficacy of Coenzyme Q10 for Improved Tolerability of Cancer Treatments: A Systematic Review
- Review, Var, NA
chemoP↑, cardioP↑, hepatoP↑, eff↝,
5801- CRMs,  Chemo,    Caloric Restriction Enhances Chemotherapy Efficacy and Reshapes Stress Responses in Sarcoma
- in-vivo, sarcoma, NA
TumCG↓, *hepatoP↑, *ROS↓, *OS↑, ChemoSen↑, chemoPv↑, selectivity↑, *DNAdam↓,
6181- Cro,    Crocetin: A Systematic Review
- Review, Var, NA - Review, AD, NA
cardioP↑, hepatoP↑, *neuroP↑, AntiCan↑, *AntiDiabetic↑, *memory↑, *BioAv↓, *ROS↓, Apoptosis↑, *lipid-P↓, *SOD↑, SOD↓, ERα/ESR1↓, HDAC2↓, TumCCA↑, Bax:Bcl2↑, IL6↓, IL8↓, Shh↓, COX2/PTGS2↑, *GSK‐3β↓, *ERK↓, *tau↓, *ROS↓, *GSTs↑, *Catalase↑, *SOD↑, *BioAv↑,
6300- Cro,    Interaction of saffron and its constituents with Nrf2 signaling pathway: A review
- Review, Nor, NA - Review, Arthritis, NA
*antiOx↑, *Inflam↓, *AntiTum↑, *hepatoP↑, *cardioP↑, *neuroP↑, *NRF2↑, *NF-kB↓, *iNOS↓, *COX2/PTGS2↓, *IL6↓, *IL10↓, *IL1β↓, *TNF-α↓, *HO-1↑, ROS↑, NQO1↑, NRF2↑, HO-1↑, NQO2↑, LDHA↓, ATP↓, *hepatoP↑, *SOD↑, *Catalase↑, *GPx↑, *NRF2↑, *ROS↓, *cardioP↑, *ER Stress↓, *GRP78/BiP↓, *CHOP/DDIT3↓, *Apoptosis↓, *miR-34a↓, *SIRT1↑, chemoP↑,
6299- Cro,    Protective Effects of Crocetin on Arsenic Trioxide-Induced Hepatic Injury: Involvement of Suppression in Oxidative Stress and Inflammation Through Activation of Nrf2 Signaling Pathway in Rats
- in-vivo, Nor, NA
*ALAT↓, *AST↓, *ALP↓, *MDA↓, *ROS↓, *Catalase↑, *SOD↑, *IL6↓, *IL1β↓, *TNF-α↓, *NRF2↑, *HO-1↑, *NADPH↑, *NQO1↑, *hepatoP↑, *GSH↑,
6297- Cro,    Crocetin Exerts Its Anti-inflammatory Property in LPS-Induced RAW264.7 Cells Potentially via Modulation on the Crosstalk between MEK1/JNK/NF-κB/iNOS Pathway and Nrf2/HO-1 Pathway
- in-vitro, Nor, RAW264.7
*NO↓, *iNOS↓, *Inflam↓, *MEK↓, JNK↓, NF-kB↓, NRF2↑, HO-1↑, hepatoP↑, neuroP↑,
6529- CRV,    D-Carvone Attenuates CCl4-Induced Liver Fibrosis in Rats by Inhibiting Oxidative Stress and TGF-ß 1/SMAD3 Signaling Pathway
- in-vivo, Nor, NA
*ALAT↓, *AST↓, *MDA↓, *SOD↑, *GSH↑, *TAC↑, *eff↑, *TGF-β1↓, *SMAD3↓, *MMP9↑, *NRF2↑, *antiOx↑, *hepatoP↑, *Inflam↓, *NF-kB↓, *NO↓, *cAMP↑, *ROS↓,
7413- CS,  Poly,    Anticancer effects induced by artichoke extract in oral squamous carcinoma cell lines
- in-vitro, SCC, SCC25
AntiCan↑, tumCV↓, TumCG↓, Apoptosis↑, selectivity↑, BAX↑, Casp9↑, Bcl-2↓, TumCCA↑, other↝, hepatoP↑,
7429- CS,    Functional and Therapeutic Potential of Cynara scolymus in Health Benefits
- Review, Nor, NA - Review, IBD, NA - Review, AD, NA
*Inflam↓, *antiOx↑, *hepatoP↑, *lipid-P↓, *TNF-α↓, *ICAM-1↓, *IL1β↓, *IL6↓, *MUC1↑, *OCLN↑, *IBI↑, *ROS↓, *cardioP↑, *SOD↑, *GPx↑, *GSH↑, *TG/TAG↓, *LDL↓, *neuroP↑, *5HT↑, *BDNF↑,
7421- CS,    Efficacy of artichoke leaf extract in non-alcoholic fatty liver disease: A pilot double-blind randomized controlled trial
- Trial, Nor, NA
*hepatoP↑, *Dose↝, *toxicity↓, *BloodF↑, *ALAT↓, *AST↓, *Bil↓, *LDL↓, *HDL↓, *TG/TAG↓,
6185- Cuc,    Cucurbitacin B: A review of its pharmacology, toxicity, and pharmacokinetics
- Review, Var, NA - Review, Arthritis, NA - Review, AD, NA
*Inflam↓, *antiOx↑, *hepatoP↑, *neuroP↑, *AntiCan↑, *toxicity↝, *BioAv↓, *HO-1↑, *NRF2↑, *NLRP3↑, *SOD↑, *SOD1↑, *ROS↓, *AntiAge↑, *ARE↑, *STAT↓, *NF-kB↓, *neuroG↑, *memory↑, ROS↑, NLRP3↑, CIP2A↓, Akt↓, STAT3↑, VEGFR2/KDR/Flk1↓, DNMTs↓, MAPK↓, YAP/TEAD↓, PI3K↓, Wnt↓, NOTCH↓, TumCCA↑, TumCG↓, TumCP↓, FAK↑, MMP9↓, TumAuto↑, toxicity↝, BioAv↓, Half-Life↝, BioAv↑, selectivity∅,

Showing Research Papers: 51 to 100 of 321
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 321

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 4,   Catalase↓, 3,   Catalase↑, 3,   GPx↑, 3,   GPx4↓, 2,   GSH↓, 13,   GSH↑, 5,   GSR↑, 1,   GSTs↑, 1,   H2O2↑, 1,   HO-1↓, 1,   HO-1↑, 8,   Iron↑, 2,   lipid-P↓, 4,   lipid-P↑, 4,   MDA↓, 2,   MDA↑, 3,   NOX↓, 1,   NOX4↓, 1,   NQO1↓, 1,   NQO1↑, 2,   NRF2↓, 3,   NRF2↑, 8,   Prx↓, 1,   PrxII↓, 1,   ROS↓, 13,   ROS↑, 63,   ROS⇅, 1,   ROS↝, 3,   i-ROS↑, 2,   mt-ROS↑, 2,   SOD?, 1,   SOD↓, 3,   SOD↑, 4,   SOD1↑, 2,   SOD2↓, 1,   SOD2↑, 1,   TAC↓, 1,   Thiols↓, 1,   Trx↓, 1,   TrxR↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 2,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↑, 1,   CDC2↓, 1,   CDC25↓, 2,   compI↓, 2,   compII↓, 1,   ETC↓, 2,   mitResp↓, 1,   mtDam↑, 5,   OXPHOS↓, 1,   PGC-1α↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,   5LO↓, 1,   ALAT↓, 13,   AMP↑, 1,   AMPK↑, 4,   ATP↓, 10,   ATP↑, 1,   mt-ATP↓, 1,   glucoNG↓, 1,   glucose↓, 1,   GlucoseCon↓, 4,   GlutMet↓, 1,   Glycolysis↓, 11,   GSK‐3β↓, 3,   GSK‐3β↑, 4,   p‑GSK‐3β↓, 1,   HK2↓, 7,   lactateProd↓, 5,   LDHA↓, 2,   PCK1↓, 1,   PDK1 / PDPK1↓, 1,   PDK3↑, 1,   PKM2↓, 1,   SCD1↓, 1,   SIRT1↓, 3,   SIRT1↑, 1,   SREBP1/SREBF1↓, 1,   TCA↓, 2,   Warburg↓, 3,  

Cell Death(tgid=5) ⓘ

AIF↑, 2,   APAF1↑, 2,   Apoptosis?, 1,   Apoptosis↓, 2,   Apoptosis↑, 61,   mt-Apoptosis↑, 1,   BAD↓, 1,   BAD↑, 3,   Bak↑, 4,   BAX↓, 1,   BAX↑, 40,   Bax:Bcl2↑, 9,   Bcl-2↓, 38,   Bcl-2↑, 2,   Bcl-xL↓, 10,   Bcl-xL↑, 1,   BIM↓, 1,   BIM↑, 2,   BNIP3↑, 1,   Casp↑, 10,   Casp1↑, 1,   Casp12↑, 1,   Casp3↑, 40,   cl‑Casp3↑, 3,   Casp7↑, 7,   cl‑Casp7↑, 1,   Casp8↑, 15,   Casp9↓, 1,   Casp9↑, 27,   cl‑Casp9↑, 2,   cFLIP↓, 1,   Cyt‑c↑, 25,   Diablo↑, 1,   DR5↑, 6,   FADD↑, 3,   Fas↑, 7,   FasL↑, 2,   Ferroptosis↑, 2,   GranB/GZMB↝, 1,   IAP1↓, 1,   IAP2/BIRC3↓, 3,   iNOS↓, 4,   Mcl-1↓, 5,   MDM2↓, 2,   MDM2↑, 1,   MOMP↑, 2,   necrosis↑, 1,   p38↓, 1,   p38↑, 9,   p‑p38↓, 2,   p‑p38↑, 2,   Perforin↝, 1,   PUMA↑, 1,   survivin↓, 13,   TRAIL↑, 1,   TumCD↓, 1,   TumCD↑, 4,   XIAP↓, 9,   XIAP↑, 1,   YAP/TEAD↓, 2,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 40,   Akt↑, 1,   Akt↝, 1,   p‑Akt↓, 5,   CIP2A↓, 1,   CK2↓, 1,   cMET↓, 3,   p‑cMET↑, 1,   CREB↓, 1,   cSrc↓, 1,   EGFR↓, 10,   ERK↓, 21,   ERK↑, 2,   p‑ERK↓, 3,   HER2/EBBR2↓, 2,   p‑HER2/EBBR2↓, 1,   HGF/c-Met↓, 1,   Hippo↑, 1,   IGF-1R↓, 1,   IKKα↓, 1,   JAK1↓, 2,   JAK2↓, 6,   JNK↓, 3,   JNK↑, 4,   p‑JNK↑, 2,   LIMK1↓, 1,   MAPK↓, 12,   MAPK↑, 6,   p‑MAPK↑, 1,   MEK↓, 2,   mTOR↓, 21,   p‑mTOR↓, 1,   mTORC2↓, 1,   p42↑, 1,   P70S6K↓, 2,   P90RSK↓, 1,   PI3K↓, 33,   PI3K↑, 1,   PI3K↝, 1,   p‑PI3K↓, 1,   PIK3CA↓, 1,   PKA↓, 1,   PKCδ↓, 2,   PTEN↓, 1,   PTEN↑, 7,   Raf↓, 1,   RAS↓, 2,   RAS↑, 1,   RET↓, 1,   SHP1↑, 1,   Sp1/3/4↓, 4,   STAT3↓, 27,   STAT3↑, 2,   p‑STAT3↓, 3,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF2↓, 1,   ATF4↑, 2,   ChrMod↑, 1,   cJun↓, 1,   cJun↑, 1,   cMyc↓, 17,   DNMT1↓, 3,   DNMT3A↓, 1,   DNMTs↓, 2,   EZH2↓, 2,   FOXO1↓, 1,   FOXO1↑, 1,   p‑FOXO3↓, 1,   p‑H3↓, 1,   HATs↑, 2,   HDAC↓, 8,   HDAC1↓, 3,   HDAC2↓, 3,   HDAC3↓, 1,   HDAC4↓, 1,   HDAC8↓, 1,   miR-124-3p↓, 1,   miR-203↑, 1,   miR-34a↓, 2,   miR-34a↑, 1,   MYCN↓, 1,   NDRG1↑, 1,   OCT4↓, 3,   other↑, 2,   other↝, 4,   PhotoS↑, 2,   sonoS↑, 1,   SOX2↓, 4,   tumCV?, 1,   tumCV↓, 14,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 4,   eIF2α↓, 1,   eIF2α↑, 2,   p‑eIF2α↑, 1,   ER Stress↑, 8,   GRP78/BiP↑, 1,   GRP78/BiP↝, 1,   HSP90↓, 3,   NQO2↑, 1,   PERK↑, 1,   p‑PERK↑, 1,   UPR↑, 2,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 2,   Beclin-1/ATG6↑, 6,   LC3II↑, 3,   LC3s↑, 1,   p62↓, 2,   TumAuto↑, 12,   VMP-1↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 1,   BRCA1↓, 1,   BRCA1↑, 1,   DNAdam↑, 14,   hTERT/TERT↓, 2,   P53↓, 2,   P53↑, 24,   p‑P53↑, 1,   PARP↓, 1,   PARP↑, 4,   cl‑PARP↓, 1,   cl‑PARP↑, 12,   PCNA↓, 13,   Telomerase↓, 2,   TOP1↓, 2,   TOP2↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 5,   CDK1↑, 2,   CDK2↓, 9,   CDK4↓, 12,   CDK4↑, 1,   CDK6↓, 3,   CDK6↑, 1,   CDK8↓, 1,   CHK1↓, 1,   CHK1↑, 1,   Chk2↑, 2,   cycA1/CCNA1↓, 2,   CycB/CCNB1↓, 10,   cycD1/CCND1↓, 23,   cycE/CCNE↓, 3,   cycE/CCNE↑, 1,   GADD45A↑, 1,   Ki-67↓, 11,   mitA↑, 1,   P21↑, 20,   p27/CDKN1B↓, 1,   p27/CDKN1B↑, 6,   pRB↓, 1,   p‑pRB↓, 1,   RB1↓, 1,   RB1↑, 1,   TumCCA↑, 61,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMP7/OP1↓, 2,   BMPs↑, 1,   CD133↓, 1,   cFos↓, 3,   CSCs?, 1,   CSCs↓, 9,   Diff↑, 1,   Gli↓, 1,   Gli1↓, 1,   HH↓, 1,   IGF-1↓, 1,   IGFBP3↑, 1,   Ki-67↓, 11,   Let-7↑, 1,   mTORC1↓, 2,   Nanog↓, 3,   Nestin↓, 1,   NOTCH↓, 7,   NOTCH↑, 1,   NOTCH1↓, 3,   NOTCH1↑, 3,   Shh↓, 3,   Smo↓, 1,   TumCG↓, 26,   TumCP↓, 44,   Wnt↓, 13,   Wnt/(β-catenin)↓, 1,  

Migration(tgid=13) ⓘ

AP-1↓, 3,   BACH1↓, 1,   CA↓, 1,   Ca+2↑, 9,   i-Ca+2↑, 1,   E-cadherin↓, 5,   E-cadherin↑, 9,   EMT↓, 21,   EMT↝, 1,   FAK↓, 4,   FAK↑, 1,   p‑FAK↓, 2,   Fibronectin↓, 1,   LAMs↓, 1,   LRP1↓, 1,   MALAT1↓, 1,   MMP1↓, 1,   MMP13↓, 1,   MMP2↓, 21,   MMP2↑, 1,   MMP7↓, 2,   MMP9↓, 26,   MMP9↑, 2,   MMPs↓, 14,   MTA1↓, 1,   MUC4↓, 3,   N-cadherin↓, 5,   p44↑, 1,   PDGF↓, 3,   Rho↓, 2,   Rho↝, 1,   ROCK1↓, 1,   Slug↓, 2,   Smad1↑, 1,   SMAD4↓, 1,   Snail↓, 2,   TET1↑, 2,   TGF-β↓, 5,   TIMP1↑, 3,   TIMP2↓, 1,   TIMP2↑, 4,   TIMP3↑, 1,   TRIB3↑, 1,   TumCI↓, 20,   TumCMig↓, 24,   TumMeta↓, 27,   TumMeta↑, 2,   Twist↓, 7,   uPA↓, 8,   Vim↓, 4,   Zeb1↓, 3,   ZEB2↓, 1,   β-catenin/ZEB1↓, 15,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 32,   angioG↑, 1,   CD31/PECAM-1↓, 1,   HIF-1↓, 2,   HIF-1↑, 1,   Hif1a↓, 20,   Hif1a↝, 1,   LOX1↓, 1,   TBXAS1/TxAS↓, 1,   VEGF↓, 29,   VEGFR2/KDR/Flk1↓, 6,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   GastroP↑, 1,   GLUT1↓, 4,   GLUT4↓, 1,   MMP↓, 27,   NHE1↓, 1,   TRPM7↓, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD4+↑, 1,   CD44↓, 4,   CD47↓, 1,   CD8+↑, 3,   COX1↓, 1,   COX2/PTGS2↓, 22,   COX2/PTGS2↑, 1,   CXCc↓, 1,   CXCR4↓, 6,   DCells↑, 1,   HMGB1↓, 1,   ICAM-1↓, 2,   IFN-γ↓, 1,   IFN-γ↑, 1,   IL1↓, 2,   IL1↑, 1,   IL10↓, 1,   IL17↓, 1,   IL1β↓, 10,   IL1β↑, 1,   IL2↓, 1,   IL2↑, 2,   IL6↓, 17,   IL8↓, 4,   Imm↑, 6,   Imm↝, 2,   INF-γ↝, 1,   Inflam↓, 21,   Inflam↝, 1,   MCP1/CCL2↓, 2,   MDSCs↓, 1,   Neut↑, 1,   NF-kB?, 1,   NF-kB↓, 45,   NF-kB↑, 1,   p‑NF-kB↑, 1,   NK cell↑, 1,   NLRP3↓, 2,   NLRP3↑, 1,   PD-1↓, 1,   PD-L1↓, 5,   PGE2↓, 7,   PSA↓, 2,   T-Cell↑, 1,   TLR4↓, 1,   TNF-α↓, 16,   TNF-α↑, 3,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 1,   Treg lymp↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

GGT/CD224↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 5,   ER(estro)↓, 2,   ERα/ESR1↓, 1,   PPARγ↓, 2,   PPARγ↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 1,   BioAv↓, 14,   BioAv↑, 17,   BioAv↝, 5,   BioEnh?, 1,   CBR1↓, 1,   ChemoSen↓, 1,   ChemoSen↑, 59,   CompStab↓, 1,   CompStab↑, 1,   CompStab↝, 2,   CYP1A1↓, 1,   CYP1A1↑, 1,   Dose?, 1,   Dose↝, 26,   eff↓, 2,   eff↑, 18,   eff↝, 6,   eff∅, 1,   Half-Life↓, 4,   Half-Life↝, 3,   MRP1/ABCC1↓, 2,   MRP1/ABCC1↝, 1,   NAT↓, 1,   P-gp/ABCB1↓, 5,   P-gp/ABCB1↑, 1,   P450↓, 1,   RadioS↑, 12,   selectivity↑, 21,   selectivity∅, 1,   Synergy↑, 35,  

Clinical Biomarkers(tgid=22) ⓘ

AFP?, 1,   AFP↓, 2,   AFP↑, 1,   ALAT↓, 13,   ALB↑, 1,   ALP↓, 3,   AR↓, 5,   AST?, 1,   AST↓, 9,   BP↓, 1,   BRCA1↓, 1,   BRCA1↑, 1,   BUN↓, 2,   creat↓, 3,   DBIL↓, 1,   E6↓, 1,   E7↓, 1,   EGFR↓, 10,   ERα/ESR1↓, 1,   EZH2↓, 2,   HER2/EBBR2↓, 2,   p‑HER2/EBBR2↓, 1,   hTERT/TERT↓, 2,   IBIL↓, 1,   IL6↓, 17,   Maspin↑, 1,   PC↑, 1,   PD-L1↓, 5,   PSA↓, 2,   RBC↑, 1,   TBIL↓, 1,   TG/TAG↓, 1,   TRIB3↑, 1,   WBC↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↓, 1,   AntiCan↑, 33,   AntiDiabetic↑, 1,   AntiTum↑, 9,   Appetite↑, 1,   BowelM↑, 1,   breath↑, 1,   cardioP↑, 16,   CardioT↑, 1,   chemoP↑, 32,   chemoPv↑, 9,   cognitive↑, 1,   hepatoP↓, 3,   hepatoP↑, 55,   hepatoP↝, 2,   hepatoP∅, 2,   Mucositis↓, 2,   neuroP↑, 11,   NP/CIPN↓, 3,   OS↓, 1,   OS↑, 6,   OS⇅, 1,   Pain↓, 3,   PFS↑, 1,   QoL↑, 4,   radioP↑, 8,   RenoP↑, 11,   RenoP∅, 1,   Risk↓, 4,   Risk↑, 1,   Sleep↑, 1,   Strength↑, 2,   toxicity↓, 11,   toxicity↑, 2,   toxicity↝, 5,   toxicity∅, 1,   TumVol?, 1,   TumVol↓, 4,   TumW↓, 1,   Weight?, 1,   Weight↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

Sepsis↓, 2,  

Ingredients & Constituents(tgid=25) ⓘ

Api↑, 1,   Ingr↝, 4,  
Total Targets: 555

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

NA↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 9,   antiOx↑, 132,   ARE↑, 4,   Bil↓, 4,   Bil↑, 2,   Catalase↓, 2,   Catalase↑, 63,   DPPH↓, 1,   Fenton↓, 4,   GCLC↑, 2,   GCLC↝, 1,   GCLM↑, 2,   GCLM↝, 1,   GPx↓, 1,   GPx↑, 48,   GPx1↑, 1,   GPx4↓, 1,   GPx4↑, 1,   GSH↓, 3,   GSH↑, 82,   GSH/GSSG↑, 1,   GSR↑, 5,   GSSG↓, 2,   GSTs↓, 1,   GSTs↑, 14,   H2O2↓, 4,   HDL↓, 2,   HDL↑, 5,   HDL∅, 1,   HO-1?, 1,   HO-1↓, 3,   HO-1↑, 38,   HO-1⇅, 1,   hyperG↓, 1,   Iron↝, 1,   i-Iron↑, 1,   Keap1↓, 6,   Keap1↝, 2,   lipid-P?, 1,   lipid-P↓, 63,   lipid-P↑, 1,   MDA↓, 65,   MDA↑, 3,   MPO↓, 11,   NADH↓, 1,   NQO1↑, 9,   NQO1↝, 2,   NRF2?, 1,   NRF2↓, 3,   NRF2↑, 69,   RNS↓, 3,   ROS?, 2,   ROS↓, 171,   ROS↑, 7,   ROS⇅, 1,   mt-ROS?, 1,   mt-ROS↓, 1,   selenoP↑, 1,   SOD↓, 3,   SOD↑, 89,   SOD1↑, 4,   SOD2↑, 2,   TAC↑, 5,   TBARS↓, 3,   Thiols↑, 2,   TOS↓, 1,   TOS↑, 1,   Trx↑, 2,   Trx1↑, 1,   uricA↓, 1,   VitC↑, 2,   VitE↑, 1,   xCT/SLC7A11↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

FTH1↓, 1,   IronCh↑, 7,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compI↓, 1,   compI↑, 1,   compII↑, 1,   compIII↓, 1,   compIII↑, 1,   DRP1/DNM1L↓, 1,   ETC↓, 1,   Insulin↓, 2,   Insulin↑, 1,   MFN2↑, 1,   mtDam↓, 6,   PDH↑, 1,   PGC-1α↑, 5,   PGC-1α↝, 2,   SIRT3↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,   15-LOX/ALOX15↓, 1,   5LO↓, 3,   5LO↝, 1,   ACADS/SCAD↑, 1,   ACC↓, 2,   ACC↑, 1,   adiP↑, 1,   ALAT↓, 77,   ALAT↑, 4,   AMPK↓, 1,   AMPK↑, 20,   p‑AMPK↑, 2,   ATP↓, 2,   ATP↑, 6,   cAMP↑, 2,   CPT1A↑, 1,   CRM↑, 3,   CYP51/14LDM↑, 1,   FABP4↓, 1,   FAM↑, 1,   FASN↓, 2,   glucose↓, 10,   glucose↝, 2,   GlucoseCon↓, 1,   GlucoseCon↑, 2,   glyC↓, 1,   Glycolysis↓, 1,   GSK‐3β↓, 7,   GSK‐3β↑, 2,   p‑GSK‐3β↑, 1,   H2S↑, 2,   HK2↓, 1,   HMG-CoA↓, 1,   lactateProd↓, 1,   LDL↓, 16,   lipidLev↓, 5,   NAD↓, 1,   NAD↑, 2,   NADPH↓, 4,   NADPH↑, 2,   NH3↓, 1,   PDKs↓, 1,   PFKP↓, 1,   PKM2↓, 2,   PLA2↓, 1,   SIRT1↑, 14,   SIRT1↝, 1,   SIRT2↑, 1,   SREBF2⇅, 1,   SREBP1/SREBF1↓, 3,   SREBP1/SREBF1↑, 1,  

Cell Death(tgid=5) ⓘ

AIF↓, 2,   Apoptosis↓, 20,   ASC↓, 1,   BAX↓, 13,   Bax:Bcl2↓, 2,   Bcl-2↓, 3,   Bcl-2↑, 8,   Casp↓, 1,   Casp1↓, 2,   Casp12↓, 1,   Casp3↓, 22,   cl‑Casp3↓, 3,   proCasp3↓, 1,   Casp8↓, 1,   cl‑Casp8↑, 1,   Casp9↓, 8,   Cyt‑c↓, 5,   Fas↓, 3,   Ferroptosis↓, 2,   Ferroptosis↑, 1,   GranB/GZMB↓, 1,   iNOS↓, 22,   iNOS↑, 1,   necrosis↓, 2,   p38↓, 5,   p‑p38↓, 1,   Pyro↓, 1,   TUNEL↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 5,   Akt↑, 9,   p‑Akt↓, 1,   p‑Akt↑, 1,   Akt2↓, 1,   AMPKα↑, 1,   ERK↓, 4,   p‑ERK↑, 1,   HGF/c-Met↑, 1,   IGF-1R↓, 1,   IKKα↓, 3,   IKKα↑, 1,   p‑IKKα↓, 1,   JAK↓, 2,   JAK2↓, 1,   JAK2↑, 1,   p‑JAK2↓, 1,   JNK↓, 8,   JNK↑, 1,   p‑JNK↓, 2,   MAPK↓, 10,   MAPK↑, 1,   p‑MAPK?, 1,   p‑MAPK↓, 1,   MEK↓, 1,   mTOR↓, 4,   mTOR↑, 4,   p‑mTOR↓, 1,   PDGFR-BB↓, 2,   PDGFRB↓, 1,   PI3K↓, 5,   PI3K↑, 6,   PKCδ↓, 1,   PP2A↑, 1,   PTEN↑, 1,   STAT↓, 2,   STAT3↓, 4,   STAT3↑, 1,   p‑STAT3↓, 1,   STAT5↓, 1,   STK11/LKB1↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 7,   ATF2↑, 1,   ATF4↓, 3,   cJun↓, 1,   p‑cJun↓, 1,   cMyc↓, 1,   DNMT1↓, 1,   FOXO1↝, 1,   FOXO3↑, 1,   HDAC↑, 1,   miR-23a-3p↓, 1,   miR-34a↓, 1,   OCT4↓, 1,   other↓, 3,   other↑, 6,   other↝, 11,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↓, 1,   CHOP/DDIT3↓, 6,   CHOP/DDIT3↑, 1,   eIF2α↓, 1,   p‑eIF2α↓, 1,   ER Stress↓, 9,   GRP78/BiP↓, 6,   GRP78/BiP↑, 1,   GRP94↑, 1,   HSP27↑, 1,   HSP70/HSPA5↓, 1,   HSP70/HSPA5↑, 1,   HSPs↓, 1,   HSPs↑, 1,   IRE1↓, 1,   XBP-1↓, 2,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↓, 1,   autophagy↑, 1,   Beclin-1/ATG6↓, 3,   Beclin-1/ATG6↑, 2,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3II↓, 1,   LC3II↑, 2,   LC3s↓, 1,   p62↑, 2,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 11,   DNArepair↑, 1,   P53↓, 4,   PARP1↓, 1,   cl‑PARP1↓, 1,   PCNA↓, 1,   Telomerase↓, 2,   TOP1↓, 1,   γH2AX↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

cycD1/CCND1↓, 1,   E2Fs↑, 1,   GADD34↓, 1,   Ki-67↓, 1,   P21↓, 2,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CEBPA↓, 1,   GH↑, 1,   HH↓, 1,   IGF-1↓, 1,   Ki-67↓, 1,   neuroG↑, 3,   TumCP↓, 2,   tyrosinase↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↓, 2,   AntiAg↑, 12,   AP-1↓, 4,   BACH1↓, 1,   Ca+2↓, 7,   Ca+2↑, 1,   Ca+2↝, 2,   Cartilage↑, 1,   COL1↓, 4,   COL1↑, 1,   COL3A1↓, 2,   E-cadherin↑, 2,   EMT↓, 3,   Fibronectin↓, 1,   LRP1↑, 1,   MLC2/MYL9↝, 1,   MMP13↓, 2,   MMP2↓, 3,   MMP2↑, 1,   MMP3↓, 1,   MMP9↓, 5,   MMP9↑, 1,   MUC1↑, 2,   PAI-1/SERPINE1↓, 1,   p‑Rac1↓, 1,   ROCK1↓, 1,   p‑SMAD2↓, 2,   SMAD3↓, 1,   p‑SMAD3↓, 1,   p‑SMAD3↑, 1,   Smad7↑, 1,   Snail↑, 1,   p‑T-cadherin↓, 1,   TGF-β↓, 7,   TGF-β↑, 2,   TGF-β1↓, 2,   TIMP1↓, 1,   TumCI↓, 1,   TumMeta↓, 1,   Twist↑, 1,   TXNIP↓, 2,   Tyro3↓, 1,   uPA↑, 1,   Vim↓, 3,   Vim↑, 1,   α-SMA↓, 10,   α-SMA↑, 1,   α-SMA↝, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   angioG↑, 2,   eNOS↑, 1,   Hif1a↓, 3,   Hif1a↑, 2,   LOX1↓, 1,   NO↓, 20,   TXA2↓, 1,   VCAM-1↓, 6,   VEGF↓, 5,   VEGF↑, 2,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 10,   BBB↝, 1,   BBB∅, 2,   GastroP↑, 10,   GLUT2↑, 1,   GLUT3↑, 1,   GLUT4↑, 3,   H+/K+-ATPase↓, 1,   IBI↑, 4,   memfluid↑, 1,   MMP↓, 1,   MMP↑, 11,   OATPs↓, 1,   OCLN↓, 1,   OCLN↑, 1,   OCLN↝, 1,   TJ↑, 2,   TRPC1↓, 1,   TRPM7↓, 1,   TRPV3↑, 1,   ZO-1↑, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD19↑, 1,   CD4+↑, 3,   CD8+↑, 1,   COX1↓, 4,   COX2/PTGS2↓, 39,   COX2/PTGS2↑, 2,   CXCL1↓, 1,   HMGB1↓, 1,   ICAM-1↓, 6,   IFN-γ↓, 10,   IL1?, 1,   IL1↓, 1,   IL10↓, 6,   IL10↑, 10,   IL12↓, 1,   IL17↓, 6,   IL18↓, 2,   IL1β↓, 39,   IL2↓, 4,   IL22↓, 1,   IL23↓, 1,   IL4↓, 5,   IL4↑, 1,   IL5↓, 1,   IL6?, 1,   IL6↓, 50,   IL6↑, 2,   IL8↓, 9,   Imm↓, 1,   Imm↑, 20,   Imm↝, 3,   Inflam↓, 158,   Inflam↑, 2,   IRF3↓, 1,   LPS↓, 2,   LTA/TNF-β↓, 1,   pol-M2 MC↑, 1,   MCP1/CCL2↓, 5,   MCT1↓, 1,   MIP2↓, 1,   MyD88↓, 4,   NeuroI↓, 2,   NF-kB↓, 67,   NK cell↑, 1,   NLRP3↓, 15,   NLRP3↑, 1,   p65↓, 3,   PGE2↓, 14,   RAGE↓, 1,   RANTES↓, 1,   TLR2↓, 1,   TLR4↓, 16,   TNF-α↓, 70,   TNF-α↑, 3,   TRIF↓, 2,  

Cellular Microenvironment(tgid=17) ⓘ

Astr↓, 1,   GGT/CD224↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   5HT↑, 4,   Ach↑, 3,   AChE↓, 24,   AChE∅, 1,   BChE↓, 5,   BDNF↓, 1,   BDNF↑, 13,   ChAT↑, 3,   DHCR7↑, 1,   GABA↑, 2,   MAOA↓, 2,   MAOB↓, 2,   NGF↑, 4,   PSD95↑, 1,   SNAP25↑, 1,   TrkB↑, 3,   β-Endo↑, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 5,   APP↓, 1,   Aβ↓, 22,   Aβ42↓, 1,   BACE/β-secretase↓, 7,   PSEN1/PS1↓, 1,   PSEN2/PS-2↓, 1,   tau↓, 4,   p‑tau↓, 5,   β-Amyloid↓, 2,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 2,   ACE2↓, 1,   BNP↓, 1,   CYP19↓, 1,   Leptin↓, 1,   PPARα↑, 3,   PPARα↝, 1,   PPARγ↓, 2,   PPARγ↑, 8,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 36,   BioAv↑, 39,   BioAv↝, 23,   BioEnh↑, 3,   ChemoSen↑, 3,   CompStab↑, 1,   CompStab↝, 1,   CYP2D6↓, 1,   CYP2E1↓, 2,   Dose?, 2,   Dose↓, 1,   Dose↑, 4,   Dose⇅, 1,   Dose↝, 47,   eff↑, 19,   eff↝, 1,   GSTA1↑, 2,   Half-Life↓, 6,   Half-Life↑, 2,   Half-Life↝, 13,   P-gp/ABCB1↓, 3,   P450↓, 2,   P450↑, 2,   P450↝, 1,   selectivity↑, 1,   Synergy↑, 14,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 77,   ALAT↑, 4,   ALB↑, 1,   ALP↓, 16,   AST↓, 75,   AST↑, 4,   BG↓, 5,   Bil↓, 4,   Bil↑, 2,   BloodF↑, 2,   BMD↑, 6,   BP↓, 6,   BUN?, 1,   BUN↓, 4,   creat↓, 11,   CRP↓, 7,   hs-CRP↓, 2,   IL6?, 1,   IL6↓, 50,   IL6↑, 2,   IRes↑, 1,   IRes↝, 1,   LDH↓, 16,   LDH↑, 1,   NOS2↓, 2,   RAGE↓, 1,   TC↓, 1,   TG/TAG↓, 4,   TMAO↓, 1,   Urea↓, 2,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 4,   AntiAge↑, 9,   antiAll↑, 18,   AntiArt↑, 10,   AntiCan↑, 35,   antiCG↑, 1,   antiD↓, 1,   AntiDiabetic↓, 2,   AntiDiabetic↑, 47,   antiNeop↑, 1,   antiPs↑, 2,   AntiTum↓, 1,   AntiTum↑, 9,   cardioP?, 1,   cardioP↑, 76,   cardioP⇅, 1,   chemoP↑, 12,   chemoPv↑, 5,   cognitive↑, 27,   cough?, 1,   diuretic↑, 5,   fatigue↓, 3,   hepatoP↓, 10,   hepatoP↑, 255,   Learn↑, 1,   memory?, 1,   memory↑, 29,   Mood↑, 1,   motorD↓, 1,   motorD↑, 5,   Mucositis↓, 1,   neuroP?, 3,   neuroP↓, 2,   neuroP↑, 106,   Obesity↓, 20,   OS↑, 4,   Pain↓, 4,   PDE4↓, 1,   QoL↑, 1,   radioP↑, 9,   RenoP↓, 1,   RenoP↑, 46,   Sleep↑, 1,   SoreThr?, 1,   Stress↓, 2,   Stroke↓, 11,   toxicity↓, 32,   toxicity↑, 1,   toxicity↝, 15,   toxicity∅, 4,   Wound Healing↓, 1,   Wound Healing↑, 6,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 15,   AntiFungal↑, 10,   AntiViral↑, 13,   Bacteria↓, 33,   Bacteria↑, 1,   Diar↓, 3,   GutMicro↑, 23,   insect↑, 1,   Sepsis↓, 4,  

Ingredients & Constituents(tgid=25) ⓘ

CA↑, 1,   Catechins↑, 1,   FA↑, 1,   GA↑, 1,   Ingr?, 2,   Ingr↝, 12,   Phen↑, 1,   QC↑, 1,  
Total Targets: 574

Scientific Paper Hit Count for: hepatoP, L,hepatoprotective
23 Silymarin (Milk Thistle) silibinin
20 Thymoquinone
11 Silver-NanoParticles
10 Baicalein
9 Carvacrol
8 Emodin
8 Selenium NanoParticles
7 Resveratrol
7 Ferulic acid
7 Hydrogen Gas
6 Chlorogenic acid
6 Chrysin
6 Dandelion Root
6 Matrine
5 Allicin (mainly Garlic)
5 Curcumin
5 Ashwagandha(Withaferin A)
5 Kaempferol
5 Licochalcone A
5 Piperine
5 Rosmarinic acid
4 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
4 Centella asiatica / Gotu kola → asiaticoside
4 Crocetin
4 EGCG (Epigallocatechin Gallate)
4 Isoliquiritigenin
4 Luteolin
4 Moringa oleifera
4 Quercetin
3 Berberine
3 Boron
3 buckwheat sprouts
3 Rutin
3 Chemotherapy
3 Cynara scolymus/Globe Artichoke/Artichoke Extract
3 Radiotherapy/Radiation
3 Hibiscus sabdariffa
3 Honokiol
3 Hyperoside
3 Isobavachalcone
3 Isovitexin
3 Linalool
3 Lycopene
3 Shikonin
2 Alpha-Lipoic-Acid
2 isoquercitrin
2 Apigenin (mainly Parsley)
2 Baicalin
2 doxorubicin
2 Betulinic acid
2 Selenium
2 Thymol-Thymus vulgaris
2 Sorafenib (brand name Nexavar)
2 Vitamin C (Ascorbic Acid)
2 Propolis -bee glue
2 methotrexate
2 Hydroxycinnamic-acid
2 Polyphenols
2 Cucurbitacin
2 Date Fruit Extract
2 Indole-3-carbinol
2 Flaxseed/Linseed
2 Fucoidan
2 Graviola
2 Licorice
2 Cisplatin
2 Mung Bean Sprouts
2 Vitexin
2 Metformin
2 Magnetic Fields
2 Morin
2 Nimbolide
2 Marjoram (Origanum majorana)
2 Ursolic acid
1 1,8-Cineole
1 Astragalus
1 Gold NanoParticles
1 Acer okamotoanum
1 Artemisinin
1 Ascorbyl Palmitate
1 Melatonin
1 Astaxanthin
1 Biochanin A
1 Bacopa monnieri
1 Boswellia (frankincense)
1 α-Bisabolol / Chamomile oil
1 Cynanbungeigenin C (CBC) and D (CBD)
1 Celastrol
1 Chlorophyllin
1 Choline
1 Chyawanprash
1 Cichoric acid / Chicoric acid
1 Cinnamon
1 Coenzyme Q10
1 Calorie Restriction Mimetics
1 Carvone
1 Diclofenac
1 diet Fermented Foods
1 Diindolylmethane
1 D-limonene
1 Ellagic acid
1 Ginkgo biloba-EGb 761
1 Eugenol
1 Sesame seeds and Oil
1 Fenbendazole
1 Fennel Oil/Foeniculum vulgare
1 Fisetin
1 Formononetin
1 Gallic acid
1 Ginkgo biloba
1 Ginger/6-Shogaol/Gingerol
1 Grapeseed extract
1 Helleborus niger extracts – Christmas Rose
1 Inositol
1 L-ornithine
1 Lactoferrin/Talactoferrin
1 Magnetic Field Rotating
1 Mucuna pruriens/Velvet Bean
1 Mistletoe/Viscum album Extracts
1 Mushroom Chaga, Inonotus obliquus
1 nicotinamide adenine dinucleotide
1 Naringin
1 Neem
1 Paclitaxel/Taxol
1 Aidi injection
1 Propyl gallate
1 Piperlongumine
1 Pterostilbene
1 Capsaicin
1 α-Santalol/Sandalwood oil
1 Sulforaphane (mainly Broccoli)
1 Vitamin K2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1179  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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