tau Cancer Research Results

tau, tau: Click to Expand ⟱
Source:
Type:
In healthy neurons, tau binds to and stabilizes microtubules, which are essential for maintaining cell structure and facilitating axonal transport.

In AD, tau becomes abnormally hyperphosphorylated. This excessive phosphorylation reduces its affinity for microtubules, leading to destabilization of the cytoskeletal structure.
-Abnormal phosphorylated tau (p-tau) can be detected in cerebrospinal fluid (CSF) and blood plasma.
-Imaging techniques like tau PET scans can visualize tau deposits in the brain.
Natural Products targeting tau
-Curcumin                via GSK-3β inhibition
-Resveratrol             Activates SIRT1
-EGCG                    inhibits Tau, but BBB penetration is questionable
Scientific Papers found: Click to Expand⟱
6824- EMD,    Neuroprotective, Anti-Inflammatory and Antifibrillogenic Offerings by Emodin against Alzheimer’s Dementia: A Systematic Review
- Review, AD, NA
*Inflam?, *antiOx↑, *tau↓, *Aβ↓, *neuroP↑, *ROS↓, *memory↑, *cognitive↑, *other↝, *AChE↓, *BACE/β-secretase↓, *LC3II↓, *Beclin-1/ATG6↓, *p‑tau↓, *CREB↑, *HNE↓, *BioAv↓, *BioAv↝, *BioAv↑, *BioAv↑, *BioAv↑, *BioAv↑, BioAv↑, *HO-1↑, *PKCδ↑, *Akt↑, *NLRP3↓, *NF-kB↓, *TLR3↓,
6826- EMD,    Exploring the therapeutic potential of natural compounds for Alzheimer's disease: Mechanisms of action and pharmacological properties
- Review, AD, NA
*AntiCan↑, *hepatoP↑, *Inflam↓, *antiOx↑, *Bacteria↓, *Aβ↓, *p‑tau↓, *BACE/β-secretase↓, *PP2A↑,
6818- EMD,    Emodin Rescued Hyperhomocysteinemia-Induced Dementia and Alzheimer's Disease-Like Features in Rats
- in-vivo, AD, NA
*Aβ↓, *p‑tau↓, *PP2A↑, *cAMP↑, *5LO↓, *IL6↓, *TNF-α↓, *ROS↓, *DNMT1↓,
6817- EMD,    Emodin inhibits aggregation of amyloid-β peptide 1–42 and improves cognitive deficits in Alzheimer's disease transgenic mice
- in-vivo, AD, NA
*Aβ↓, *tau↓, *ROS↓, *Inflam↓, *cognitive↑,
3830- EMD,    Traditional Chinese Medicine: Role in Reducing β-Amyloid, Apoptosis, Autophagy, Neuroinflammation, Oxidative Stress, and Mitochondrial Dysfunction of Alzheimer’s Disease
- Review, AD, NA
*neuroP↑, *Aβ↓, *p‑tau↓, *BACE/β-secretase↓,
6954- FA,    Folic acid as a potential therapeutic agent for Alzheimer's disease: Effects on inflammatory cytokines, amyloid deposition, and neurotransmitter metabolism
- Trial, AD, NA
*Inflam↓, *Aβ↓, *IL1β↓, *IL6↓, *TNF-α↓, *tau↓, *GABA↑, *5HT↑, *Ach↑, *ALB↑, *HemoG↑, *neuroP↑, *Hcy/homoC↓,
4071- FA,    Folate and Alzheimer: when time matters
- Review, AD, NA
*cognitive↑, *ROS↓, *Ca+2↓, *p‑tau↓, *Aβ↓,
3715- FA,  CUR,  PS,    The Additive Effects of Low Dose Intake of Ferulic Acid, Phosphatidylserine and Curcumin, Not Alone, Improve Cognitive Function in APPswe/PS1dE9 Transgenic Mice
- in-vivo, AD, NA
*cognitive↑, *IL1β↓, *Ach↑, *Aβ↓, *p‑tau↓, *BDNF↑, *APP↓,
3782- FA,    Ferulic acid ameliorates bisphenol A (BPA)-induced Alzheimer’s disease-like pathology through Akt-ERK crosstalk pathway in male rats
- in-vivo, AD, NA
*cognitive↑, *ERK↓, *p‑Akt↓, *AChE↓, *BACE/β-secretase↓, *neuroP↑, *ROS↓, *MDA↓, *GSH↑, *GSSG↓, *p‑tau↓, *lipid-P↓, *Aβ↓,
6907- FIS,    Fisetin stimulates autophagic degradation of phosphorylated tau via the activation of TFEB and Nrf2 transcription factors
- in-vitro, AD, NA
*p‑tau↓, *NRF2↑, *mTORC1↓, *neuroP↑, *memory↑, *Inflam↓, *memory↑, *TFEB↑, *mTOR↓,
6931- FLS,    Gamma frequency sensory stimulation in mild probable Alzheimer's dementia patients: Results of feasibility and pilot studies
- Trial, AD, NA
*tau↓, *Aβ↓, *other↝, *other↑, *memory↑, *other↑,
6981- Form,    Formononetin: a review of its source, pharmacology, drug combination, toxicity, derivatives, and drug delivery systems
- Review, Var, NA - Review, AD, NA - Review, PSA, NA
BioAv↝, *memory↑, *ROS↓, *AChE↓, *NF-kB↓, *Keap1↝, *NRF2↑, *Inflam↓, *PGC-1α↝, *HO-1↓, *p‑tau↓, *cognitive↑, *BDNF↑, *5HT↑, *Stroke↓, *PARP1↓, *AIF↓, *Casp3↓, NP/CIPN↓, *neuroP↑, *NGF↑, *TNF-α↓, *IL1β↓, *IL18↓, *IL6↓, *VCAM-1↓, *pol-M2 MC↑, *hepatoP↑, *AST↓, *ALAT↓, *LC3II↑, *Beclin-1/ATG6↑, *p62↑, *COX2/PTGS2↑, *MMP↑, *ATP↑, *GSH↑, *Catalase↑, *GPx↑, *MDA↓, *antiPs↑, *AntiDiabetic↑, *glucose↓, *Insulin↑, *GutMicro↑, *Obesity↓, COX2/PTGS2↓, cycD1/CCND1↓, TumCCA↑, EGFR↓, GSK‐3β↑, Mcl-1↓, *toxicity↓, TumCP↓, Hif1a↓, VEGF↓, ERK↓, LAMs↓, Cyt‑c↑, Casp9↑, Casp3↑, PARP↑, TumCD↑, mitA↑, BACH1↓, P53↓, ROS↑, PD-1↓, NF-kB↓, *Bacteria↓, *AntiViral↑, *mt-ROS?, *PI3K↓, *chemoP↑, ChemoSen↑, Synergy↑, *toxicity↓, *BioAv↑, *BioAv↑, *Synergy↑, *antiAll↑,
4016- FulvicA,    Shilajit: A Natural Phytocomplex with Potential Procognitive Activity
- Review, AD, NA
*tau↓, *AntiAge↑, *Strength↑, *Dose↝, *BioAv↑, *antiOx↑, *memory↑, *Inflam↓, *cognitive↑, *neuroP↑, *toxicity↝, *toxicity↑,
4017- FulvicA,    Fulvic acid inhibits aggregation and promotes disassembly of tau fibrils associated with Alzheimer's disease
- in-vivo, AD, NA
*cognitive↑, *tau↓,
4020- FulvicA,    Natural products as a rich source of tau-targeting drugs for Alzheimer’s disease
- in-vitro, AD, NA
*tau↓, *cognitive↑,
4021- FulvicA,    Scaling the Andean Shilajit: A Novel Neuroprotective Agent for Alzheimer’s Disease
- in-vitro, AD, NA
*tau↓, *neuroP↑,
4025- FulvicA,    Mumio (Shilajit) as a potential chemotherapeutic for the urinary bladder cancer treatment
- in-vitro, Bladder, T24/HTB-9 - Review, AD, NA
tumCV↓, selectivity↑, TumCCA↑, other↝, *neuroP↑, *memory↑, *tau↓, *other↝, *lipid-P↓, *VitC↑, *antiOx↑,
3723- GBE,    Can We Use Ginkgo biloba Extract to Treat Alzheimer’s Disease? Lessons from Preclinical and Clinical Studies
- Review, AD, NA
*memory↑, *antiOx↑, *Casp3↓, *APP↓, *AChE↓, *Aβ↓, *5HT↑, *SOD↓, *MDA↓, *NO↓, *GSH↑, *Bcl-2↑, *BAX↑, *TNF-α↓, *IL1β↑, *iNOS↓, *IL10↓, *p‑tau↓, *ROS↓, *MAOB↓, *cognitive↑, *neuroP↑, *Apoptosis↓,
4302- Gins,    Panax ginseng: A modulator of amyloid, tau pathology, and cognitive function in Alzheimer's disease
- Review, AD, NA
*neuroP↑, *Aβ↓, *p‑tau↓, *cognitive↑, *eff↑, *PKA↑, *CREB↑, *BACE/β-secretase↓, *ADAM10↑, *MAPK↑, *ERK↑, *PI3K↑, *Akt↑, *NRF2↑, *PPARγ↓, *IDE↑, *APP↓, *PP2A↑, *memory↑,
4301- Gins,    Red Ginseng Inhibits Tau Aggregation and Promotes Tau Dissociation In Vitro
- in-vitro, AD, NA
*p‑tau↓, *eff↑, *Inflam↓,
4243- Gins,    Effects of Ginseng on Neurological Disorders
- Review, Stroke, NA - Review, AD, NA - Review, Park, NA
*BDNF↑, *TrkB↑, *neuroP↑, *VEGF↑, *p‑tau↓, *memory↑,
4003- Gins,    Neuroprotective Potentials of Panax Ginseng Against Alzheimer's Disease: A Review of Preclinical and Clinical Evidences
- Review, adrenal, NA
*neuroP↑, *Inflam↓, *ROS↓, *BACE/β-secretase↓, *PPARγ↑, *Aβ↓, *p‑tau↓, *NF-kB↓, *IL1β↓, *IL6↓, *TNF-α↓, *ROS↓, *CREB↓, *BDNF↑, *memory↑,
3829- Gins,    Traditional Chinese Medicine: Role in Reducing β-Amyloid, Apoptosis, Autophagy, Neuroinflammation, Oxidative Stress, and Mitochondrial Dysfunction of Alzheimer’s Disease
- Review, AD, NA
*cognitive↑, *neuroP↑, *Aβ↓, *tau↓, *PI3K↑, *Akt↑, *memory↑,
4308- H2,    A biomimetic upconversion nanoreactors for near-infrared driven H2 release to inhibit tauopathy in Alzheimer's disease therapy
- in-vivo, AD, NA
*BioAv↝, *ROS↓, *p‑tau↓, *Dose↝, *cognitive↑,
3771- H2,    Molecular Hydrogen Neuroprotection in Post-Ischemic Neurodegeneration in the Form of Alzheimer’s Disease Proteinopathy: Underlying Mechanisms and Potential for Clinical Implementation—Fantasy or Reality?
- Review, AD, NA - Review, Stroke, NA
*cognitive↑, AntiCan↑, *Inflam↓, *antiOx↑, *ROS↓, *neuroP↑, *SOD↑, *GPx↑, *MDA↑, *BBB↑, *OS↑, *Ca+2↓, *APP↓, *p‑tau↓,
3764- H2,    Therapeutic Effects of Hydrogen Gas Inhalation on Trimethyltin-Induced Neurotoxicity and Cognitive Impairment in the C57BL/6 Mice Model
- in-vivo, AD, NA
*memory↑, *Aβ↓, *p‑tau↓, *BAX↓, *ROS↓, *NO↓, *Ca+2↓, *MDA↓, *Catalase↓, *GPx↓, *TNF-α↓, *Bcl-2↑, *VEGF↑, *Inflam↓, *cognitive↑,
3768- H2,    Effects of Hydrogen Gas Inhalation on Community-Dwelling Adults of Various Ages: A Single-Arm, Open-Label, Prospective Clinical Trial
- Trial, AD, NA
*ROS↓, *NO↓, *BACE/β-secretase↓, *BDNF↑, *VEGF↑, *p‑tau↓, *MCP1/CCL2↓, *IL6↓, *cognitive↑, *toxicity∅,
7496- H2S,    Hydrogen sulfide is neuroprotective in Alzheimer's disease by sulfhydrating GSK3β and inhibiting Tau hyperphosphorylation
- in-vivo, AD, NA
*neuroP↑, *cognitive↑, *p‑tau↓, *Dose↝,
6869- HCAs,  FA,  CA,  RosA,    Exploring the potential of cinnamic acid analogues in alzheimer's disease
- Review, AD, NA
*neuroP↑, *antiOx↓, *Inflam↓, *tau↓, *BioAv↓, *BBB↓, *BioAv↑,
2869- HNK,    Nature's neuroprotector: Honokiol and its promise for Alzheimer's and Parkinson's
- Review, AD, NA - Review, Park, NA
*neuroP↑, *Inflam↓, *motorD↑, *Aβ↓, *p‑tau↓, *cognitive↑, *memory↑, *ERK↑, *p‑Akt↑, *PPARγ↑, *PGC-1α↑, *MMP↑, *mt-ROS↓, *SIRT3↑, *IL1β↓, *TNF-α↓, *GRP78/BiP↓, *CHOP/DDIT3↓, *NF-kB↓, *GSK‐3β↓, *β-catenin/ZEB1↑, *Ca+2↓, *AChE↓, *SOD↑, *Catalase↑, *GPx↑,
7544- HYP,    Long-term oral administration of hyperoside ameliorates AD-related neuropathology and improves cognitive impairment in APP/PS1 transgenic mice
- in-vivo, AD, NA
*Learn↑, *memory↑, *Aβ↓, *p‑tau↓, *Inflam↓, *ROS↓, *BACE/β-secretase↓, *GSK‐3β↓,
7709- IBC,    Isobavachalcone ameliorates cognitive deficits, and Aβ and tau pathologies in triple-transgenic mice with Alzheimer's disease
- in-vivo, AD, NA
*Dose↝, *ANXi↓, *memory↑, *Aβ↓, *p‑tau↓,
7865- isoO,    Isoorientin inhibits oxidative stress to ameliorate cognitive dysfunction in type 2 diabetes mice via GSK3β/Nrf2 axis
- in-vivo, Diabetic, NA
*cognitive↑, *PSD95↑, *BDNF↑, *Bax:Bcl2↓, *cl‑Casp3↓, *ROS↓, *mtDam↓, *GSK‐3β↓, *NRF2↑, *HO-1↑, *p‑tau↓, *neuroP↑,
7851- isoO,    Isoorientin, a GSK-3β inhibitor, rescues synaptic dysfunction, spatial memory deficits and attenuates pathological progression in APP/PS1 model mice
- in-vivo, AD, NA
*GSK‐3β↓, *neuroP↑, *p‑tau↓, *Aβ↓, *NeuroI↓, *cognitive↑, *neuroP↑,
7867- isoO,    Prevention and Treatment of Alzheimer's Disease Via the Regulation of the Gut Microbiota With Traditional Chinese Medicine
- Review, AD, NA
*p‑GSK‐3β↓, *p‑tau↓, *Aβ↓, *memory↑, *GutMicro↑,
7822- isoO,    Isoorientin Affects Markers of Alzheimer's Disease via Effects on the Oral and Gut Microbiota in APP/PS1 Mice
- in-vivo, AD, NA
*Aβ↓, *Dose↝, *p‑tau↓, *p‑p65↓, *NF-kB↓, *LPS↓, *TNF-α↓, *IL4↑, *IL10↑, *GutMicro↑,
7836- ISQ,    An Isoquinolinium Dual Inhibitor of Cholinesterases and Amyloid β Aggregation Mitigates Neuropathological Changes in a Triple-Transgenic Mouse Model of Alzheimer's Disease
- in-vivo, AD, NA
*AChE↓, *Aβ↓, *BBB↑, *Ach↑, *cognitive↑, *APP↓, *tau↓, *eff↑,
9232- ITCs,  SFN,    The role of isothiocyanate-rich plants and supplements in neuropsychiatric disorders: a review and update
- Review, AD, NA
*ROS↓, *Inflam↓, *eff↑, *toxicity↓, *HDAC?, *neuroP↑, *NRF2↑, *cognitive↑, *tau↓, *HSP70/HSPA5↑, *CHIP↑, *memory↑, *NeuroI↓, *ROS↓, *BACE/β-secretase↓, *BDNF↑, *GSH↑, *GPx↑, *AChE↓, *BChE↓, *TC↓, *TG/TAG↓, *LDL↓, ROS↑,
4007- K+,    The increased potassium intake improves cognitive performance and attenuates histopathological markers in a model of Alzheimer's disease
- in-vivo, AD, NA
*p‑tau↓, *cognitive↑, *Inflam↓, *ROS↓, *IL6↓, *4-HNE↓, *other↝,
8054- KAE,    Kaempferol Improves Alzheimer's Disease by Inhibiting Neuronal Ferroptosis via Activating GPX4/AKR1C3 Signaling Pathway
- vitro+vivo, AD, NA
*AKR1B10↝, *MDA↓, *ROS↓, *GSH↑, *SOD↑, *GPx4↑, *NQO1↑, *xCT/SLC7A11↑, *NRF2↑, *HO-1↑, *cognitive↑, *Aβ↓, *p‑tau↓, *Ferroptosis↓, *AKR1C3/17β-HSD5/PGF Synthase↑, *AKR1B1/ALR2↑,
8234- LCA,    Licochalcone A: A Potential Multitarget Drug for Alzheimer’s Disease Treatment
- Review, AD, NA
*neuroP↑, *PTP1B↓, *cognitive↑, *BDNF↑, *TrkB↝, *cJun↓, *p‑tau↓, *AChE↓, *Ach↑, *Aβ↓, *antiOx↑, *NRF2↑, *AntiViral↑, *Obesity↓, *PI3K↑, *Akt↑, *mTOR↑, *memory↑, *BBB↑,
8135- LF,    Lactoferrin-A Regulator of Iron Homeostasis and Its Implications in Cancer
- Review, Var, NA - Review, AD, NA
IronCh↑, ROS↓, Imm↑, Inflam↓, *BBB↑, Iron↝, *Fenton↓, *ROS↓, *TAC↑, *SOD↑, *GPx↑, *GSH↑, *TBARS↓, *PTEN↓, *tau↓, *MAPK↓, *Aβ42↓, *Apoptosis↓, *Casp3↓, *Akt↑, *GutMicro↑, *Sepsis↓, *anemia↓, *IL6↓, *FPN↑, *TfR1/CD71↑, *Ferritin↓, *HemoG↑, *RBC↑, *eff↑, *BioAv↓, *BioAv↑, *BioAv↝, *ChemoSen↑, *BioAv↑, Ferroptosis↑,
8144- LF,    A pilot study on the effect of lactoferrin on Alzheimer's disease pathological sequelae: Impact of the p-Akt/PTEN pathway
- Human, AD, NA
*Ach↑, *5HT↑, *TAC↑, *Inflam↓, *Akt↑, *PI3K↑, *Aβ42↓, *LDL↓, *ROS↓, *IL6↓, *HSP90↓, *Casp3↓, *tau↓, *MAPK↓, *PTEN↓, *cognitive↑, *Dose↝,
7825- LT,  MBS,    Neuroprotective Potential of Mung Bean (Vigna radiata L.) Polyphenols in Alzheimer's Disease: A Review
- Review, AD, NA
*neuroP↑, *OS↑, *antiOx↑, *Aβ42↓, *AChE↓, *Aβ↓, *IRes↓, *p‑tau↓, *ROS↓, *Apoptosis↓, *Inflam↓, *Iron↝,
4295- LT,    Luteolin Reduces Alzheimer’s Disease Pathologies Induced by Traumatic Brain Injury
- in-vivo, AD, NA
*Aβ↓, *GSK‐3β↓, *p‑tau↓, *BBB↑,
4294- LT,    Luteolin reduces zinc-induced tau phosphorylation at Ser262/356 in an ROS-dependent manner in SH-SY5Y cells
- in-vitro, AD, SH-SY5Y
*tau↓, *antiOx↑,
4293- LT,    Regulatory Role of NF-κB on HDAC2 and Tau Hyperphosphorylation in Diabetic Encephalopathy and the Therapeutic Potential of Luteolin
- in-vivo, Diabetic, NA
*Inflam↓, *antiOx↑, *neuroP↑, *cognitive↑, *p‑mTOR↓, *p‑NF-kB↓, *HDAC2↓, *BDNF↑, *other↓, *p‑tau↓,
4292- LT,    Luteolin for neurodegenerative diseases: a review
- Review, AD, NA - Review, Park, NA - Review, MS, NA - Review, Stroke, NA
*Inflam↓, *antiOx↑, *neuroP↑, *BioAv↝, *BBB↑, *TNF-α↓, *IL1β↓, *IL6↓, *IL8↓, *IL33↓, *NF-kB↓, *BACE/β-secretase↓, *ROS↓, *SOD↑, *HO-1↑, *NRF2↑, *Casp3↓, *Casp9↑, *Bax:Bcl2↓, *UPR↑, *GRP78/BiP↑, *Aβ↓, *GSK‐3β↓, *tau↓, *CREB↑, *ATP↑, *cognitive↑, *BloodF↑, *BDNF↑, *TrkB↑, *memory↑, *PPARγ↑, *Synergy↑,
3268- Lyco,    Lycopene as a Natural Antioxidant Used to Prevent Human Health Disorders
- Review, AD, NA
*BioAv↓, *AntiCan↑, *ROCK1↓, *Ki-67↓, *ICAM-1↓, *cardioP↑, *antiOx↑, *NQO1↑, *HO-1↑, *TNF-α↓, *IL22↓, *NRF2↑, *NF-kB↓, *MDA↓, *Catalase↑, *SOD↑, *GSH↑, *cognitive↑, *tau↓, *hepatoP↑, *MMP2↑, *AST↓, *ALAT↓, *P450↑, *DNAdam↓, *ROS↓, *neuroP↑, *memory↑, *Ca+2↓, *Dose↝, *Dose↑, *Dose↝, *toxicity∅, PGE2↓, CDK2↓, CDK4↓, STAT3↓, NOX↓, NOX4↓, ROS↓, *SREBP1/SREBF1↓, *FASN↓, *ACC↓,
8413- Lyco,  VitE,    Dietary Lycopene Supplementation Improves Cognitive Performances in Tau Transgenic Mice Expressing P301L Mutation via Inhibiting Oxidative Stress and Tau Hyperphosphorylation
- in-vivo, AD, NA
*memory↑, *MDA↓, *GPx↑, *tau↓, *Synergy↑,

Showing Research Papers: 51 to 100 of 177
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 177

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   Iron↝, 1,   NOX↓, 1,   NOX4↓, 1,   NRF2↓, 1,   ROS↓, 3,   ROS↑, 6,   SOD↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

MFN2↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

Glycolysis↓, 1,   GSK‐3β↑, 1,   SIRT1↓, 1,   SREBP2↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 5,   BAX↓, 1,   BAX↑, 2,   Bax:Bcl2↑, 1,   Bcl-2↓, 1,   Casp3↑, 3,   cl‑Casp3⇅, 1,   Casp9↑, 4,   Cyt‑c↑, 3,   Ferroptosis↑, 1,   Mcl-1↓, 1,   MDM2↓, 1,   Necroptosis↑, 1,   p38↑, 1,   survivin↓, 1,   TumCD↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 2,   EGFR↓, 2,   ERK↓, 2,   HER2/EBBR2↓, 1,   MAPK↓, 1,   MAPK↝, 1,   MARK4↓, 1,   mTOR↝, 1,   PI3K↓, 1,   PKCδ↓, 2,   RAS↓, 1,   STAT3↓, 3,  

Transcription & Epigenetics(tgid=7) ⓘ

cMyc↓, 1,   HDAC2↓, 1,   miR-25-5p↓, 1,   other↝, 1,   tumCV↓, 2,  

Protein Folding & ER Stress(tgid=8) ⓘ

ER Stress↑, 1,   HSP70/HSPA5↓, 2,   HSP90↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

TumAuto↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 2,   P53↓, 1,   P53↑, 1,   PARP↑, 2,   cl‑PARP↑, 2,   TOP2↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1,   CDK2↓, 2,   CDK4↓, 2,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 1,   mitA↑, 1,   TumCCA↑, 7,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Shh↓, 1,   TumCP↓, 4,  

Migration(tgid=13) ⓘ

AntiAg?, 1,   BACH1↓, 1,   Ca+2↑, 1,   EMT↓, 2,   KRAS↓, 1,   LAMs↓, 1,   MMP2↓, 1,   MMP9↓, 1,   Smad1↓, 1,   TGF-β↓, 2,   TumCI↓, 2,   TumCMig↓, 2,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 4,   Hif1a↓, 2,   VEGF↓, 5,  

Barriers & Transport(tgid=15) ⓘ

GLUT1↓, 1,   MMP↓, 2,   TRPV1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 4,   COX2/PTGS2↑, 1,   IFN-γ↑, 1,   IL12↑, 1,   IL1β↓, 1,   IL6↓, 1,   IL8↓, 1,   Imm↑, 2,   Inflam↓, 1,   NF-kB↓, 3,   PD-1↓, 1,   PGE2↓, 1,   TNF-α↓, 3,  

Protein Aggregation(tgid=19) ⓘ

p‑tau↓, 2,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ERα/ESR1↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 1,   BioAv↝, 1,   ChemoSen↑, 5,   Dose↝, 1,   eff↑, 2,   Half-Life↓, 1,   P-gp/ABCB1↓, 2,   selectivity↑, 3,   Synergy↑, 11,  

Clinical Biomarkers(tgid=22) ⓘ

EGFR↓, 2,   ERα/ESR1↓, 1,   HER2/EBBR2↓, 1,   IL6↓, 1,   KRAS↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 3,   cardioP↑, 2,   hepatoP↑, 1,   memory↑, 1,   NP/CIPN↓, 1,   Obesity↓, 1,  
Total Targets: 119

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↓, 2,   antiOx↓, 4,   antiOx↑, 57,   ARE↑, 1,   Catalase↓, 1,   Catalase↑, 17,   Fenton↓, 1,   GPx↓, 1,   GPx↑, 15,   GPx4↑, 2,   GSH↓, 1,   GSH↑, 25,   GSR↓, 1,   GSR↑, 3,   GSSG↓, 1,   GSTs↑, 3,   H2O2↓, 1,   HDL↑, 1,   HNE↓, 1,   HO-1?, 1,   HO-1↓, 1,   HO-1↑, 19,   HO-2↓, 1,   hyperG↓, 1,   Iron↝, 1,   Keap1↝, 1,   lipid-P↓, 24,   MDA↓, 19,   MDA↑, 2,   MPO↓, 3,   NOX↓, 1,   NQO1↑, 5,   Nrf1↑, 2,   NRF2↓, 2,   NRF2↑, 31,   RNS↓, 2,   ROS?, 1,   ROS↓, 93,   mt-ROS?, 1,   mt-ROS↓, 1,   SOD↓, 1,   SOD↑, 30,   mt-SOD↑, 1,   SOD2↑, 1,   TAC↑, 7,   TBARS↓, 2,   Thiols↑, 1,   Trx1↑, 1,   TrxR↑, 1,   VitC↑, 1,   xCT/SLC7A11↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1,   Ferritin↑, 1,   FPN↑, 1,   IronCh↑, 3,   TfR1/CD71↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compIV↑, 2,   compV↑, 1,   ETC↑, 1,   FIS1↓, 1,   Insulin↑, 1,   mitResp↑, 1,   mtDam↓, 3,   OCR↑, 2,   PDH↑, 1,   PGC-1α↓, 1,   PGC-1α↑, 4,   PGC-1α↝, 1,   SIRT3↑, 3,   TFAM↑, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 2,   ACC↓, 1,   Acetyl-CoA↓, 1,   Acetyl-CoA↑, 1,   ALAT↓, 2,   AMPK↑, 10,   ATP↑, 10,   cAMP↑, 2,   FAO↑, 1,   FASN↓, 1,   glucose↓, 1,   GlucoseCon↑, 3,   Glycolysis↑, 1,   GSK‐3β↓, 33,   GSK‐3β↑, 3,   p‑GSK‐3β↓, 1,   p‑GSK‐3β↑, 2,   ac‑Histones↑, 1,   HK1↑, 1,   LDL↓, 7,   NAD↑, 1,   NADPH↓, 2,   NADPH↑, 1,   PDKs↓, 1,   SIRT1↓, 1,   SIRT1↑, 6,   SIRT1∅, 1,   SREBP1/SREBF1↓, 1,  

Cell Death(tgid=5) ⓘ

AIF↓, 1,   Apoptosis↓, 12,   BAX↓, 5,   BAX↑, 2,   Bax:Bcl2↓, 2,   Bcl-2↓, 1,   Bcl-2↑, 7,   Casp↓, 1,   Casp1↓, 1,   Casp3↓, 9,   Casp3↑, 1,   cl‑Casp3↓, 1,   Casp9↑, 1,   Ferroptosis↓, 3,   iNOS↓, 10,   necrosis↓, 1,   p‑p38↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 3,   Akt↑, 15,   p‑Akt↓, 2,   p‑Akt↑, 3,   CaMKII ↓, 2,   CREB↓, 1,   CREB↑, 5,   p‑CREB↑, 4,   DYRK1A↓, 2,   ERK↓, 2,   ERK↑, 2,   p‑ERK↓, 1,   JNK↓, 2,   p‑JNK↓, 1,   MAPK↓, 6,   MAPK↑, 1,   mTOR↓, 6,   mTOR↑, 2,   p‑mTOR↓, 1,   PI3K↓, 4,   PI3K↑, 12,   PKA↑, 3,   PKCδ↑, 2,   PP2A↑, 8,   PTEN↓, 2,   PTP1B↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

cJun↓, 1,   DNMT1↓, 1,   HDAC?, 1,   HDAC↓, 1,   HDAC2↓, 1,   MEF2D↑, 1,   other↓, 1,   other↑, 6,   other↝, 12,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 3,   ER Stress↓, 3,   GRP78/BiP↓, 4,   GRP78/BiP↑, 1,   HSP70/HSPA5↑, 3,   HSP90↓, 1,   HSPs↝, 1,   IRE1↓, 1,   p‑PERK↓, 1,   UPR↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 1,   autophagy↓, 1,   Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 3,   CTSZ↓, 1,   CTSZ↝, 1,   LC3B↑, 2,   LC3II↓, 1,   LC3II↑, 2,   lysosome↑, 1,   MitoP↑, 3,   p62↓, 1,   p62↑, 2,   PARK2↑, 1,   TFEB↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 3,   P53↓, 2,   PARP1↓, 1,   SIRT6↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK5↓, 6,   cellSen↝, 1,   Ki-67↓, 1,   Ki-67↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CHIP↑, 2,   Ki-67↓, 1,   Ki-67↑, 1,   mTORC1↓, 1,   neuroG↑, 3,   Wnt↑, 3,  

Migration(tgid=13) ⓘ

AntiAg↑, 1,   Ca+2↓, 10,   Ca+2↝, 1,   cal2↓, 1,   Cartilage↑, 1,   LRP1↑, 1,   MMP-10↝, 1,   MMP2↑, 1,   MMP3↓, 1,   MMP9↓, 1,   N-cadherin↑, 1,   ROCK1↓, 1,   TXNIP↓, 3,   β-catenin/ZEB1↑, 4,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   angioG↑, 1,   CD31/PECAM-1↑, 1,   Hif1a↓, 1,   Hif1a↑, 2,   NO↓, 7,   NO↑, 1,   VCAM-1↓, 2,   VEGF↑, 6,  

Barriers & Transport(tgid=15) ⓘ

BBB?, 1,   BBB↓, 3,   BBB↑, 30,   BBB↝, 1,   BBB∅, 1,   CellMemb↑, 1,   CX43/GJA1↑, 1,   GLUT3↑, 2,   GLUT4↑, 2,   MMP↑, 8,   THBD↑, 1,   TRPA1↑, 1,   TRPV1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

AIF1/Iba-1↓, 1,   CB2 / CNR2↑, 1,   COX1↓, 1,   COX2/PTGS2↓, 11,   COX2/PTGS2↑, 1,   ICAM-1↓, 1,   IFN-γ↓, 2,   IL1↓, 1,   IL10↓, 2,   IL10↑, 3,   IL12↓, 2,   IL17↓, 2,   IL18↓, 1,   IL1α↓, 1,   IL1β↓, 22,   IL1β↑, 1,   IL2↓, 2,   IL22↓, 1,   IL23↓, 1,   IL33↓, 1,   IL4↓, 1,   IL4↑, 3,   IL6↓, 26,   IL8↓, 2,   Imm↑, 1,   INF-γ↑, 1,   Inflam?, 1,   Inflam↓, 84,   Inflam↑, 1,   IRF3↓, 1,   LPS↓, 1,   pol-M2 MC↑, 1,   MCP1/CCL2↓, 6,   MIP‑1α/CCL3↓, 1,   MyD88↓, 1,   NeuroI↓, 9,   NF-kB↓, 29,   p‑NF-kB↓, 3,   NLRP3↓, 10,   p‑p65↓, 1,   PGE2↓, 1,   RANTES↓, 1,   TLR2↓, 1,   TLR3↓, 1,   TLR4↓, 4,   TNF-α↓, 37,  

Cellular Microenvironment(tgid=17) ⓘ

GFAP↓, 3,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 5,   Ach↑, 13,   AChE↓, 37,   ADAM10↑, 4,   BChE↓, 7,   BDNF↓, 1,   BDNF↑, 20,   BrainVol↑, 1,   CARTPT↑, 1,   ChAT↑, 6,   CHRM1↑, 1,   GABA↑, 1,   MAOA↓, 3,   MAOB↓, 4,   NGF↑, 2,   PSD95↑, 2,   RELN↑, 1,   SNAP25↑, 1,   SYP↑, 1,   TrkB↓, 1,   TrkB↑, 2,   TrkB↝, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 3,   APP↓, 15,   APP↝, 1,   Aβ↓, 100,   Aβ42↓, 5,   BACE/β-secretase↓, 31,   IDE↑, 1,   PSEN1/PS1↓, 2,   tau?, 1,   tau↓, 69,   p‑tau↓, 106,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AKR1C3/17β-HSD5/PGF Synthase↑, 1,   ER(estro)↑, 1,   PPARα↑, 4,   PPARγ↓, 2,   PPARγ↑, 6,  

Drug Metabolism & Resistance(tgid=21) ⓘ

AKR1B1/ALR2↑, 1,   AKR1B10↝, 1,   BioAv↓, 14,   BioAv↑, 24,   BioAv↝, 6,   ChemoSen↑, 1,   CompStab↑, 2,   DDS↑, 1,   Dose?, 1,   Dose↓, 2,   Dose↑, 2,   Dose↝, 25,   eff↓, 1,   eff↑, 11,   Half-Life↑, 1,   Half-Life↝, 1,   P450↑, 1,   Synergy↑, 16,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 2,   ALB↑, 1,   anemia↓, 1,   AST↓, 2,   BloodF↑, 2,   BP↓, 1,   CRP↓, 1,   Ferritin↓, 1,   Ferritin↑, 1,   Hcy/homoC↓, 1,   HemoG↑, 2,   IL6↓, 26,   IRes↓, 1,   NOS2↓, 1,   RBC↑, 1,   TC↓, 2,   TG/TAG↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 2,   antiAll↑, 3,   AntiCan↑, 7,   AntiDiabetic↑, 4,   AntiMyl↑, 1,   antiPs↑, 1,   ANXi↓, 1,   cardioP↑, 10,   chemoP↑, 1,   cognitive↑, 93,   cognitive↝, 1,   diuretic↑, 1,   fatigue↓, 1,   hepatoP↓, 1,   hepatoP↑, 7,   Learn?, 1,   Learn↑, 7,   memory?, 1,   memory↑, 83,   Mood↑, 3,   motorD↓, 1,   motorD↑, 7,   neuroP↑, 110,   Obesity↓, 4,   OS↑, 4,   Pain↓, 2,   radioP↑, 1,   RenoP↑, 1,   Risk↓, 7,   Sleep↑, 4,   Strength↑, 5,   Stress↓, 1,   Stroke↓, 5,   toxicity↓, 9,   toxicity↑, 1,   toxicity↝, 2,   toxicity∅, 3,   Wound Healing↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 2,   AntiFungal↑, 1,   AntiViral↑, 4,   Bacteria↓, 4,   GutMicro↑, 13,   Sepsis↓, 2,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 3,  
Total Targets: 390

Scientific Paper Hit Count for: tau, tau
9 Curcumin
9 Resveratrol
9 Urolithin
7 Mung Bean Sprouts
7 EGCG (Epigallocatechin Gallate)
6 Cinnamon
6 Emodin
5 Berberine
5 Selenium NanoParticles
5 Shilajit/Fulvic Acid
5 Ginseng
5 Luteolin
5 Methylene blue
5 Quercetin
4 Caffeic acid
4 Capsaicin
4 Hydrogen Gas
4 isoorientin
4 Vitamin B1/Thiamine
3 Bacopa monnieri
3 Folic Acid, Vit B9
3 Ferulic acid
3 Rosmarinic acid
3 Sulforaphane (mainly Broccoli)
3 Vitexin
3 Isovitexin
3 Mangiferin
3 Moringa oleifera
3 Morin
3 Mushroom Lion’s Mane, Hericium erinaceus
3 Thymoquinone
2 Alpha-Lipoic-Acid
2 Ashwagandha(Withaferin A)
2 Baicalein
2 Chlorogenic acid
2 Crocetin
2 Lactoferrin/Talactoferrin
2 Lycopene
2 Magnolol
2 Magnetic Fields
2 Melatonin
2 Vitamin B3,Niacin
2 Vitamin K2
1 1,8-Cineole
1 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
1 Aromatherapy
1 Beta-Caryophyllene
1 xanthohumol
1 Caffeic Acid Phenethyl Ester (CAPE)
1 Calorie Restriction Mimetics
1 Phosphatidylserine
1 Fisetin
1 Flickering Light Stimulation
1 Formononetin
1 Ginkgo biloba
1 hydrogen sulfide
1 Hydroxycinnamic-acid
1 Honokiol
1 Hyperoside
1 Isobavachalcone
1 isoquercitrin
1 Isothiocyanates
1 Potassium
1 Kaempferol
1 Licochalcone A
1 Vitamin E
1 Magnesium
1 Silver-NanoParticles
1 Zeolite
1 Methylsulfonylmethane
1 L-Theanine
1 nicotinamide adenine dinucleotide
1 Phenylbutyrate
1 Protocatechuic acid
1 Piperine
1 Pterostilbene
1 chitosan
1 Rutin
1 S-adenosyl-L-methionine
1 Carvacrol
1 Shankhpushpi
1 Silymarin (Milk Thistle) silibinin
1 Ursolic acid
1 Vitamin A, Retinoic Acid
1 Vitamin B12
1 Vitamin B5,Pantothenic Acid
1 Vitamin D3
1 probiotics
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1231  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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