Diff Cancer Research Results

Diff, differentiation: Click to Expand ⟱
Source:
Type:
Differentiation refers to the process by which cells become specialized in structure and function.
-In healthy tissues, cells undergo differentiation to become specialized types (e.g., muscle cells, neurons, blood cells) that perform specific functions. This process is tightly regulated by genetic and epigenetic factors.
-In some cases, cells can lose their specialized characteristics, a process known as dedifferentiation. This is often seen in cancer, where tumor cells revert to a more primitive, less differentiated state.
Scientific Papers found: Click to Expand⟱
3198- SFN,    Sulforaphane and TRAIL induce a synergistic elimination of advanced prostate cancer stem-like cells
- in-vitro, Pca, NA
Nanog↓, SOX2↓, E-cadherin↓, Snail↓, VEGFR2/KDR/Flk1↓, Diff↓, TumCMig↓, EMT↓, CXCR4↓, NOTCH1↓, ALDH1A1↓, CSCs↓, Synergy↑,
2212- SK,    Shikonin Exerts an Antileukemia Effect against FLT3-ITD Mutated Acute Myeloid Leukemia Cells via Targeting FLT3 and Its Downstream Pathways
- in-vitro, AML, NA
FLT3↓, NF-kB↓, miR-155↓, Diff↑, TumCG↓,
1345- SK,    The Critical Role of Redox Homeostasis in Shikonin-Induced HL-60 Cell Differentiation via Unique Modulation of the Nrf2/ARE Pathway
- in-vitro, AML, HL-60
CD14↑, CD11b↑, ROS↑, GSH↓, GSH/GSSG↓, GPx↑, Catalase↓, Diff↑,
2132- TQ,    Thymoquinone treatment modulates the Nrf2/HO-1 signaling pathway and abrogates the inflammatory response in an animal model of lung fibrosis
- in-vivo, Nor, NA
*Weight∅, *antiOx↑, *lipid-P↓, *MMP7↓, *Casp3↓, *BAX↓, *TGF-β↓, *Diff↑, *NRF2↓, *HO-1↓, *NF-kB↓, *IκB↑,
5019- UA,    Ursolic acid in colorectal cancer: mechanisms, current status, challenges, and future research directions
- Review, Var, NA
TumCP↓, Diff↑, Apoptosis↑, TumCI↓, angioG↓,

Showing Research Papers: 51 to 55 of 55
Prev Page 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 55

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 2,   Catalase↓, 1,   GPx↑, 1,   GSH↓, 2,   GSH/GSSG↓, 1,   HO-1↓, 1,   lipid-P↑, 1,   NOX2↑, 1,   NRF2∅, 1,   ROS↓, 1,   ROS↑, 11,   mt-ROS↑, 2,   TrxR↓, 1,   xCT/SLC7A11↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1,   IronCh↑, 1,   IronCh∅, 1,   Tf↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ETC↑, 1,   mtDam↑, 1,   OXPHOS↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 3,   ATP↓, 1,   ATP∅, 1,   DHODH↓, 1,   Glycolysis↓, 1,   LDL↓, 1,   NADH:NAD↓, 1,   SIRT1↑, 1,   TCA↑, 1,   Warburg↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 17,   BAX↑, 2,   Bax:Bcl2↑, 2,   Bcl-2↓, 4,   Bcl-xL↓, 2,   Casp↑, 1,   Casp3↑, 3,   cl‑Casp3↑, 1,   Casp8↑, 2,   Casp9↑, 4,   cl‑Casp9↑, 1,   Cyt‑c↑, 2,   Ferroptosis↑, 1,   Mcl-1↓, 1,   necrosis↑, 1,   survivin↓, 1,   TumCD↓, 1,   TumCD↑, 2,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 7,   p‑Akt↓, 2,   EGFR↓, 1,   ERK↓, 3,   p‑ERK↑, 1,   FLT3↓, 1,   HER2/EBBR2↓, 1,   JAK↓, 1,   JAK2↓, 2,   JNK↓, 1,   MAPK↓, 1,   MAPK↑, 2,   MEK↓, 1,   p‑MEK↑, 1,   mTOR↓, 1,   mTOR↑, 1,   p‑mTOR↓, 1,   PI3K↓, 6,   PKCδ↓, 1,   PP2A↑, 1,   PTEN↑, 1,   Raf↓, 1,   RAS↓, 3,   p‑S6K↓, 1,   p‑Src↓, 1,   STAT↓, 2,   STAT3↓, 3,   STAT4↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

H3K9↓, 1,   HDAC↓, 3,   HDAC8↓, 1,   miR-155↓, 1,   Myc↓, 1,   n-MYC↓, 1,   Prot↓, 1,   SOX2↓, 2,   SUV39H↓, 1,   tumCV↓, 2,  

Autophagy & Lysosomes(tgid=9) ⓘ

TumAuto↑, 2,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 5,   hTERT/TERT↓, 1,   P53↑, 3,   PARP↓, 1,   cl‑PARP↑, 1,   Telomerase↓, 1,   TOP2↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↑, 1,   CDK2↓, 1,   CDK2↑, 1,   CDK4↓, 2,   CDK4↑, 1,   CDK6↑, 1,   cycD1/CCND1↓, 5,   cycE/CCNE↓, 1,   E2Fs↓, 1,   Ki-67↓, 1,   P21↓, 2,   P21↑, 2,   p27/CDKN1B↓, 3,   p27/CDKN1B↑, 2,   pRB↓, 2,   p‑pRB↓, 1,   TumCCA↑, 9,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH1A1↓, 1,   BMPs↑, 1,   CD133↓, 2,   CD24↓, 1,   CSCs↓, 4,   CSCs↑, 1,   Diff↓, 4,   Diff↑, 33,   Ki-67↓, 1,   p‑mTORC1↓, 1,   Nanog↓, 1,   Nestin↓, 1,   NOTCH↓, 2,   NOTCH1↓, 1,   TumCG↓, 13,   TumCP↓, 13,   Wnt↓, 3,  

Migration(tgid=13) ⓘ

Ca+2↑, 2,   Ca+2↝, 1,   Cav1↓, 1,   CD11b↑, 3,   E-cadherin↓, 1,   E-cadherin↑, 2,   EMT↓, 3,   p‑FAK↓, 1,   Fibronectin↓, 1,   KRAS↓, 1,   MMP2↓, 4,   MMP9↓, 3,   MMP9↑, 1,   N-cadherin↓, 2,   Snail↓, 1,   TumCI↓, 6,   TumCMig↓, 4,   TumMeta↓, 4,   TXNIP↑, 1,   uPA↓, 1,   Vim↓, 1,   β-catenin/ZEB1↓, 3,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 4,   HIF-1↓, 1,   Hif1a↓, 1,   NO↓, 1,   VEGF↓, 2,   VEGFR2/KDR/Flk1↓, 3,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   CellMemb↑, 1,   EPR↑, 1,   MMP↓, 4,   MPT↑, 1,   VGCC↑, 1,   VGSC↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CCR7↓, 1,   CD14↑, 1,   CD44↓, 1,   COX2/PTGS2↓, 3,   CXCR4↓, 2,   HLA-I/II↑, 1,   IL1β↓, 2,   IL1β↑, 1,   IL6↓, 1,   Imm↑, 4,   Inflam↓, 6,   MCP1/CCL2↓, 1,   NF-kB↓, 5,   NK cell↑, 1,   PD-1↓, 1,   PD-L1↓, 1,   PGE2↓, 2,   TNF-α↓, 1,   TNF-α↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 2,   BioAv↝, 1,   ChemoSen↑, 10,   Dose?, 1,   Dose↓, 1,   Dose↑, 2,   Dose↝, 5,   eff↓, 1,   eff↑, 4,   eff↝, 1,   P-gp/ABCB1↓, 1,   RadioS↑, 7,   selectivity↑, 10,   selectivity↝, 1,   Synergy↑, 10,  

Clinical Biomarkers(tgid=22) ⓘ

CRP↓, 1,   EGFR↓, 1,   Ferritin↓, 1,   HER2/EBBR2↓, 1,   hTERT/TERT↓, 1,   IL6↓, 1,   KRAS↓, 1,   Myc↓, 1,   PD-L1↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 4,   AntiTum↓, 1,   AntiTum↑, 2,   chemoP↑, 2,   chemoPv↑, 1,   kidSt↓, 1,   neuroP↑, 1,   OS↑, 1,   QoL↑, 3,   Remission↑, 1,   RenoP↑, 1,   toxicity↓, 5,   toxicity↝, 1,   TumVol↓, 1,   TumW↓, 1,   Wound Healing↑, 1,  
Total Targets: 223

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 5,   Catalase↑, 1,   GPx↑, 1,   HO-1↓, 1,   HO-1↑, 2,   Iron∅, 1,   lipid-P↓, 4,   MDA↓, 1,   NQO1↑, 1,   NRF2↓, 1,   NRF2↑, 3,   RNS↓, 1,   ROS↓, 4,   ROS↑, 2,   SOD↑, 1,   SOD2↓, 1,   Trx↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

mtDam↓, 1,   OXPHOS↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

FABP4↓, 1,   PONs↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 2,   BAX↓, 1,   Casp3↓, 1,   Casp3↑, 1,   Cyt‑c↑, 1,   iNOS↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↑, 1,   ERK↓, 1,   ERK↑, 1,   IκB↑, 1,   p‑JNK↑, 2,   MAPK↓, 1,   MAPK↑, 1,   mTOR↑, 1,   PKA↑, 1,   PKCδ↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

miR-34b-5p↓, 1,   other↑, 3,   RUNX2↑, 1,   RUNX2∅, 1,   SOX9↑, 2,  

Protein Folding & ER Stress(tgid=8) ⓘ

HSP70/HSPA5↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMP2↑, 2,   Diff↓, 2,   Diff↑, 14,   Diff↝, 2,   MSCs↑, 1,   TumCG↑, 1,   TumCP↓, 1,   Wnt↑, 2,  

Migration(tgid=13) ⓘ

Ca+2↑, 2,   COL1∅, 1,   COL2A1↑, 2,   F-actin↑, 1,   FAK↑, 1,   MMP7↓, 1,   MMP9↑, 1,   OPN↑, 1,   STAC2↑, 1,   TGF-β↓, 1,   TGF-β↑, 1,   β-catenin/ZEB1↑, 2,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↑, 1,   angioG↝, 1,   HIF2a↑, 1,   NO↓, 2,   VEGF↓, 1,   VEGF↑, 2,  

Barriers & Transport(tgid=15) ⓘ

IBI↑, 1,   MMP↑, 1,   TRPC1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 2,   IL10↑, 2,   IL1β↓, 2,   IL6↓, 3,   Imm↑, 1,   Inflam↓, 9,   NF-kB↓, 2,   PGE2↓, 1,   PSA↓, 1,   TNF-α↓, 3,   TNF-α↑, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   BDNF↑, 1,   TPH1↓, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

PPARγ↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 1,   Dose↝, 7,   eff↑, 4,   eff↝, 1,   Synergy↑, 2,  

Clinical Biomarkers(tgid=22) ⓘ

ALP↑, 1,   ALP∅, 1,   BloodF↑, 1,   BMD↑, 4,   IL6↓, 3,   OCN↑, 1,   OCN∅, 1,   PSA↓, 1,   UFR↑, 1,   UR↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiDiabetic↑, 1,   AntiTum↑, 1,   cardioP↑, 1,   chemoPv↑, 1,   cognitive↑, 1,   diuretic↑, 1,   hepatoP↑, 1,   motorD↑, 1,   neuroP↑, 3,   RenoP↑, 1,   toxicity↓, 3,   toxicity∅, 1,   Weight↓, 1,   Weight∅, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 1,   Bacteria↓, 1,   GutMicro↑, 1,   Inf↓, 1,  
Total Targets: 123

Scientific Paper Hit Count for: Diff, differentiation
12 Magnetic Fields
6 phytic acid, Inositol hexakisphosphate
4 Inositol
3 Magnetic Field Rotating
3 Phenylbutyrate
3 salinomycin
2 Artemisinin
2 Dandelion Root
2 Emodin
2 Isobavachalcone
2 Shikonin
1 Auranofin
1 Silver-NanoParticles
1 Berberine
1 chaetocin
1 Chrysin
1 Crocetin
1 Electrical Pulses
1 Fucoidan
1 Arsenic trioxide
1 Vitamin A, Retinoic Acid
1 Hydrogen Gas
1 isoquercitrin
1 Lecithin
1 Luteolin
1 Exercise
1 Niclosamide (Niclocide)
1 Radiotherapy/Radiation
1 Phenethyl isothiocyanate
1 Quercetin
1 Vorinostat
1 Sulfasalazine
1 Sulforaphane (mainly Broccoli)
1 Thymoquinone
1 Ursolic acid
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1235  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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