Gli1 Cancer Research Results

Gli1, glioma-associated oncogene homolog 1: Click to Expand ⟱
Source:
Type: HH
Gli family zinc-finger transcription factors; GLI1‐dependent target genes (CyclinD1, Bcl‐2, Foxm1)

Glioma-associated oncogene homolog 1 (GLI1) is a transcription factor that plays a significant role in the Hedgehog signaling pathway, which is crucial for cell growth, differentiation, and tissue patterning during embryonic development.
GLI1 can promote tumor growth and survival by regulating the expression of genes involved in cell proliferation, apoptosis, and angiogenesis. Its overexpression has been associated with aggressive tumor behavior and poor prognosis in several cancer types.
ts overexpression is often associated with aggressive tumor behavior, poor prognosis, and resistance to therapy
Scientific Papers found: Click to Expand⟱
1731- SFN,    Targeting cancer stem cells with sulforaphane, a dietary component from broccoli and broccoli sprouts
- Review, Var, NA
CSCs↓, ChemoSen↑, NF-kB↓, Shh↓, Smo↓, Gli1↓, GLI2↓, PI3K↓, Wnt↓, β-catenin/ZEB1↓, Nanog↓, COX2↓, Zeb1↓, Snail↓, ChemoSideEff↓, eff↑, *BioAv↑,
1733- SFN,    Sonic Hedgehog Signaling Inhibition Provides Opportunities for Targeted Therapy by Sulforaphane in Regulating Pancreatic Cancer Stem Cell Self-Renewal
- in-vitro, PC, PanCSC - in-vitro, Nor, HPNE - in-vitro, Nor, HNPSC
CSCs↓, Shh↓, Gli↓, Nanog↓, OCT4↓, PDGFRA↓, cycD1/CCND1↑, Apoptosis↑, Casp↑, Smo↓, Gli1↓, GLI2↓, Bcl-2↓, Casp3↑, Casp7↑,
109- SIL,    Silibinin induces apoptosis through inhibition of the mTOR-GLI1-BCL2 pathway in renal cell carcinoma
- vitro+vivo, RCC, 769-P - in-vitro, RCC, 786-O - in-vitro, RCC, ACHN - in-vitro, RCC, OS-RC-2
HH↓, Gli1↓, GLI2↓, mTOR↓, Bcl-2↓, Apoptosis↑, Casp3↑, PARP↑, TumCG↓,
107- SS,    Saikosaponin B1 and Saikosaponin D inhibit tumor growth in medulloblastoma allograft mice via inhibiting the Hedgehog signaling pathway
- vitro+vivo, MB, LS174T
HH↓, Smo↓, Gli↓, Gli1↓, PTCH1↓, TumCG↓,
112- SuD,    Inhibition of Gli/hedgehog signaling in prostate cancer cells by “cancer bush” Sutherlandia frutescens extract
- in-vitro, Pca, PC3 - in-vitro, Pca, LNCaP
HH↓, Gli1↓, PTCH1↓, TumCG↓, chemoPv↑, eff↑,
113- TQ,    Selective Targeting of the Hedgehog Signaling Pathway by PBM Nanoparticles in Docetaxel-Resistant Prostate Cancer
- vitro+vivo, Pca, C4-2B
HH↓, Shh↓, Gli1↓, eff↑, TumCP↓,
115- VitD3,    Vitamin D3 Inhibits Hedgehog Signaling and Proliferation in Murine Basal Cell Carcinomas
- in-vivo, RCC, NA - in-vivo, BCC, NA
HH↓, GLI2↓, Shh↓, Gli1↓, Ki-67↓, TumCP↓,

Showing Research Papers: 51 to 57 of 57
Prev Page 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 57

Pathway results for Effect on Cancer / Diseased Cells:


Cell Death ⓘ

Apoptosis↑, 2,   Bcl-2↓, 2,   Casp↑, 1,   Casp3↑, 2,   Casp7↑, 1,  

DNA Damage & Repair ⓘ

PARP↑, 1,  

Cell Cycle & Senescence ⓘ

cycD1/CCND1↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

CSCs↓, 2,   Gli↓, 2,   Gli1↓, 7,   HH↓, 5,   mTOR↓, 1,   Nanog↓, 2,   OCT4↓, 1,   PDGFRA↓, 1,   PI3K↓, 1,   PTCH1↓, 2,   Shh↓, 4,   Smo↓, 3,   TumCG↓, 3,   Wnt↓, 1,  

Migration ⓘ

GLI2↓, 4,   Ki-67↓, 1,   Snail↓, 1,   TumCP↓, 2,   Zeb1↓, 1,   β-catenin/ZEB1↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   NF-kB↓, 1,  

Drug Metabolism & Resistance ⓘ

ChemoSen↑, 1,   eff↑, 3,  

Clinical Biomarkers ⓘ

Ki-67↓, 1,  

Functional Outcomes ⓘ

chemoPv↑, 1,   ChemoSideEff↓, 1,  
Total Targets: 34

Pathway results for Effect on Normal Cells:


Drug Metabolism & Resistance ⓘ

BioAv↑, 1,  
Total Targets: 1

Scientific Paper Hit Count for: Gli1, glioma-associated oncogene homolog 1
7 Curcumin
7 EGCG (Epigallocatechin Gallate)
6 Resveratrol
6 Sulforaphane (mainly Broccoli)
3 Apigenin (mainly Parsley)
3 Genistein (soy isoflavone)
3 Rosmarinic acid
2 Baicalein
2 Betulinic acid
2 Cynanbungeigenin C (CBC) and D (CBD)
2 Glabrescione B
1 Acoschimperoside P, 2’-acetate
1 Andrographis
1 Quercetin
1 Berberine
1 Chemotherapy
1 Carvacrol
1 Thymol-Thymus vulgaris
1 Cyclopamine
1 Deguelin
1 Ellagic acid
1 Garcinol
1 Germacranolide
1 Graviola
1 Siegesbeckia glabrescens
1 itraconazole
1 Physalin F & B
1 salinomycin
1 Silymarin (Milk Thistle) silibinin
1 Saikosaponin B1 and D
1 Sutherlandioside D
1 Thymoquinone
1 Vitamin D3
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:124  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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