AChE Cancer Research Results

AChE, acetylcholinesterase: Click to Expand ⟱
Source:
Type:
AChE is an enzyme that rapidly hydrolyzes the neurotransmitter acetylcholine into choline and acetate, terminating cholinergic signals.
- In some cancers, studies have reported reduced AChE activity, which may contribute to an accumulation of acetylcholine.
- Lower levels or loss of AChE expression/activity have been associated with more aggressive tumor behavior and poor prognosis, possibly due to unchecked cholinergic signaling.

For AD (Alzheimer's), AChE inhibitors are used, to allow ACh, and ChAT to increase along with acetyl-CoA
-Natural AChE inhibitors: Ferulic Acid, Caffeic Acid, Rosmarinic Acid, Sage
-AChE inhibitors only temporarily relieve some of the disease’s cognitive symptoms and do not stop the patient’s cognitive loss
-adverse effects such as disorientation, falls, dizziness, and fatigue may occur with these medications and should be used only as recommended

- Natural AChE inhibitors paper
Scientific Papers found: Click to Expand⟱
3635- Cro,    A Review of Potential Efficacy of Saffron (Crocus sativus L.) in Cognitive Dysfunction and Seizures
- Review, NA, NA
*memory↑, *cognitive↑, *BioAv↑, *ROS↓, *IL1↓, *TNF-α↓, *NF-kB↓, *neuroP↑, *lipid-P↓, *Thiols↑, *antiOx↑, *AChE↓, *MAOA↝, *SIRT1↑, *PGC-1α↑, *Ach↑,
3637- Cro,    Investigation of the neuroprotective action of saffron (Crocus sativus L.) in aluminum-exposed adult mice through behavioral and neurobiochemical assessment
- NA, AD, NA
*cognitive∅, *MAOA↓, *MDA↓, *GSH↑, *AChE↓,
6216- CUR,    Role of Turmeric and Curcumin in Prevention and Treatment of Chronic Diseases: Lessons Learned from Clinical Trials
- Review, Var, NA
TumCG↓, angioG↓, EMT↓, TumCI↓, TumMeta↓, *GutMicro↑, *BioAv↓, *HO-1↑, *ROS↓, *COX2↓, *iNOS↓, PKCδ↓, EGFR↓, NF-kB↓, cJun↓, cFos↓, cMyc↓, Akt↓, PI3K↓, CDK4↓, *TNF-α↓, *CRP↓, *IL6↓, MMP9↓, VEGF↓, JAK↓, STAT↓, IL1↓, IL2↓, IL6↓, IL8↓, IL12↓, MCP1↓, Apoptosis↑, ER Stress↑, 5LO↓, XO↓, *NRF2↑, *HO-1↑, *AChE↓, *neuroP↑, *glucose↓, *GLUT2↑, *GLUT3↑, *GLUT4↑, *GlucoseCon↑, *AMPK↑, *BMD↑, *MDA↓, *eff↑, eff↑, P53↑, BAX↑, DNAdam↑, Bcl-2↓, CSCs↓, ALDH↓, CD133↑,
6050- CUR,  SeNPs,    Efficacy of curcumin-selenium nanoemulsion in alleviating oxidative damage induced by aluminum chloride in a rat model of Alzheimer's disease
- in-vivo, AD, NA
*cognitive↑, *AChE↓, *Aβ↓, *P53↓, *tau↓, *NRF2↓, *TNF-α↓, *NO↑, *Catalase↑, *antiOx↑, *Inflam↓,
3753- CUR,  Gala,    A Novel Galantamine–Curcumin Hybrid Inhibits Butyrylcholinesterase: A Molecular Dynamics Study
- Study, AD, NA
*BChE↓, *AChE↓, *Ach↑, *cognitive↑, *memory↑, *ROS↓, *Inflam↓, *NF-kB↓, *COX2?,
3794- CUR,    Curcumin hybrid molecules for the treatment of Alzheimer's disease: Structure and pharmacological activities
- Review, AD, NA
*GSK‐3β↓, *CDK5↓, *p‑tau↓, *IronCh↑, *ROS↓, *HO-1↑, *SOD↑, *Catalase↑, *GSH↑, *TNF-α↓, *IL6↓, *IL12↓, *NRF2↑, *PPARγ↑, *IL4↑, *AChE↓, *Dose↝, *GutMicro↑,
3752- CUR,    Revealing the molecular interplay of curcumin as Culex pipiens Acetylcholine esterase 1 (AChE1) inhibitor
- in-vivo, AD, NA
*AChE↓,
3751- CUR,  Gala,    A Novel Galantamine-Curcumin Hybrid as a Potential Multi-Target Agent against Neurodegenerative Disorders
- in-vivo, AD, NA
*AChE↓, *MDA↑, *GSH↑, *BBB↑,
3750- CUR,  PI,    Synergistic Effects of Curcumin and Piperine as Potent Acetylcholine and Amyloidogenic Inhibitors With Significant Neuroprotective Activity in SH-SY5Y Cells via Computational Molecular Modeling and in vitro Assay
- in-vitro, AD, SH-SY5Y
*AChE↓, *neuroP↑,
3748- CUR,  RES,  Hup,  Riv,  Gala  Natural acetylcholinesterase inhibitors: A multi-targeted therapeutic potential in Alzheimer's disease
- Review, AD, NA
*AChE↓, *Inflam↓, *Aβ↓, *cognitive↑, *ROS↓,
3760- CUR,  GI,  CAP,  RosA,  PI  Extending the lore of curcumin as dipteran Butyrylcholine esterase (BChE) inhibitor: A holistic molecular interplay assessment
*AChE↓, *other↓, *other↓, *other↓, *other↓, *other↓, *other↓,
3795- CUR,    Curcumin: A Golden Approach to Healthy Aging: A Systematic Review of the Evidence
- Review, AD, NA
*antiOx↑, *Inflam↓, *AntiAge↑, *AMPK↑, *SIRT1↑, *NF-kB↓, *mTOR↓, *NLRP3↓, *NADPH↓, *ROS↓, *COX2↓, *MCP1↓, *IL1β↓, *IL17↓, *IL23↓, *TNF-α↓, *MPO↓, *IL10↑, *lipid-P↓, *SOD↑, *Aβ↓, *p‑tau↓, *GSK‐3β↓, *CDK5↓, *TXNIP↓, *NRF2↑, *NQO1↑, *HO-1↑, *OS↑, *memory↑, *BDNF↑, *neuroP↑, *BACE↓, *AChE↓, *LDL↓,
3584- CUR,    Curcumin in Health and Diseases: Alzheimer’s Disease and Curcumin Analogues, Derivatives, and Hybrids
*AChE↓, *Inflam↓, *antiOx↑, *Aβ↓, *ROS↓,
3576- CUR,    Protective Effects of Indian Spice Curcumin Against Amyloid-β in Alzheimer's Disease
- Review, AD, NA
*Inflam↓, *antiOx↑, *memory↑, *Aβ↓, *BBB↑, *cognitive↑, *tau↓, *LDL↓, *AChE↓, *IL1β↓, *IronCh↑, *neuroP↑, *BioAv↝, *PI3K↑, *Akt↑, *NRF2↑, *HO-1↑, *Ferritin↑, *HO-2↓, *ROS↓, *Ach↑, *GSH↑, *Bcl-2↑, *ChAT↑,
6288- DL,    From Citrus to Clinic: Limonene’s Journey Through Preclinical Research, Clinical Trials, and Formulation Innovations
- Review, Var, NA - Review, AD, NA
other↑, DDS↑, *antiOx↑, *Inflam↓, *AntiDiabetic↑, *neuroP↑, *Imm↑, *Wound Healing↑, *other↑, *BioAv↑, *ROS↓, *SOD↑, *Catalase↑, *GSH↑, *DNAdam↓, *AntiDiabetic↑, Casp3↑, Casp9↑, BAX↑, Bcl-2↓, *AChE↓, *BChE↓, *Aβ↓, *ROS↓, *toxicity?,
6281- DL,    Applications of Limonene in Neoplasms and Non-Neoplastic Diseases
- Review, Var, NA - Review, AD, NA - Review, Diabetic, NA
*antiOx↑, AntiTum↑, *AntiDiabetic↑, *neuroP↑, *GastroP↑, *ROS↓, *toxicity↓, *BioAv↑, ChemoSen↑, BAX↑, P53↓, Bcl-2↓, iNOS↓, COX2↓, eff↑, ROS↑, TumCCA↑, cycD1/CCND1↓, CycB/CCNB1↓, TumCMig↓, *lipid-P↓, *GSH↑, *SOD↑, *GPx↑, *hepatoP↑, *glucose↓, *AGEs↓, *Obesity↓, *Aβ↓, *AChE↓,
3756- EA,    Acetylcholinesterase and monoamine oxidase-B inhibitory activities by ellagic acid derivatives isolated from Castanopsis cuspidata var. sieboldii
- Analysis, AD, NA
*AChE↓, *BACE↓, *MAOB↓,
3591- EGCG,    Epigallocatechin-3-Gallate Provides Protection Against Alzheimer's Disease-Induced Learning and Memory Impairments in Rats
- in-vivo, AD, NA
*p‑tau↓, *BACE↓, *Aβ↓, *Ach↑, *AChE↓, *antiOx↑, *memory↑, *hepatoP↑, *ROS↓, *GPx↑, *SOD↑,
3783- FA,    Design, Synthesis, and Biological Evaluation of Ferulic Acid-Piperazine Derivatives Targeting Pathological Hallmarks of Alzheimer’s Disease
- NA, AD, NA
*ROS↓, *IronCh↑, *NLRP3↓, *Aβ↓, *AChE↓, *BChE↓, *antiOx↑, *BBB↑, *MMP↑, *memory↑, *SOD↑, *Catalase↑,
3782- FA,    Ferulic acid ameliorates bisphenol A (BPA)-induced Alzheimer’s disease-like pathology through Akt-ERK crosstalk pathway in male rats
- in-vivo, AD, NA
*cognitive↑, *ERK↓, *p‑Akt↓, *AChE↓, *BACE↓, *neuroP↑, *ROS↓, *MDA↓, *GSH↑, *GSSG↓, *p‑tau↓, *lipid-P↓, *Aβ↓,
3781- FA,    Therapeutic potential of ferulic acid and its derivatives in Alzheimer’s disease—A systematic review
- Review, AD, NA
*antiOx↑, *Inflam↓, *BBB↑, *AChE↓, *BChE↓,
3780- FA,    Ferulic Acid: A Natural Antioxidant with Application Towards Neuroprotection Against Alzheimer’s Disease
- Review, AD, NA
*antiOx↑, *SOD↑, *Catalase↑, *HO-1↑, *neuroP↑, *AChE↓, *MMP↑,
3779- FA,    A review on ferulic acid and analogs based scaffolds for the management of Alzheimer’s disease
- Review, AD, NA
*antiOx↑, *neuroP↑, *Aβ↓, *Inflam↓, *COX2↓, *Casp↓, *NOS2↓, *HO-1↑, *AChE∅, *BChE∅, *memory↑,
3710- FA,    Therapeutic Potential of Ferulic Acid in Alzheimer's Disease
- Review, AD, NA
*antiOx↑, *AntiCan↑, *Inflam↓, *hepatoP↑, *cardioP↑, *neuroP↑, *Aβ↓, *ROS↓, *AChE↓,
3711- FA,    A review on ferulic acid and analogs based scaffolds for the management of Alzheimer's disease
- Review, AD, NA
*antiOx↑, *neuroP↑, *Aβ↓, *Inflam↓, *AChE↓, *IronCh↑,
3713- FA,    Protective Effect of Ferulic Acid on Acetylcholinesterase and Amyloid Beta Peptide Plaque Formation in Alzheimer’s Disease: An In Vitro Study
- Review, AD, NA
*AChE↓, *antiOx↑, *neuroP↑, *Aβ↓, *MMP↓, *XO↓, *SOD↑, *lipid-P↑, *ROS↓,
3723- Gb,    Can We Use Ginkgo biloba Extract to Treat Alzheimer’s Disease? Lessons from Preclinical and Clinical Studies
- Review, AD, NA
*memory↑, *antiOx↑, *Casp3↓, *APP↓, *AChE↓, *Aβ↓, *5HT↑, *SOD↓, *MDA↓, *NO↓, *GSH↑, *Bcl-2↑, *BAX↑, *TNF-α↓, *IL1β↑, *iNOS↓, *IL10↓, *p‑tau↓, *ROS↓, *MAOB↓, *cognitive↑, *neuroP↑, *Apoptosis↓,
2869- HNK,    Nature's neuroprotector: Honokiol and its promise for Alzheimer's and Parkinson's
- Review, AD, NA - Review, Park, NA
*neuroP↑, *Inflam↓, *motorD↑, *Aβ↓, *p‑tau↓, *cognitive↑, *memory↑, *ERK↑, *p‑Akt↑, *PPARγ↑, *PGC-1α↑, *MMP↑, *mt-ROS↓, *SIRT3↑, *IL1β↓, *TNF-α↓, *GRP78/BiP↓, *CHOP↓, *NF-kB↓, *GSK‐3β↓, *β-catenin/ZEB1↑, *Ca+2↓, *AChE↓, *SOD↑, *Catalase↑, *GPx↑,
3805- Hup,    Isolation, diversity and acetylcholinesterase inhibitory activity of the culturable endophytic fungi harboured in Huperzia serrata from Jinggang Mountain, China
- Analysis, AD, NA
*AChE↓,
3804- Hup,    Huperzine A for Alzheimer's disease: a systematic review and meta-analysis of randomized clinical trials
- Review, AD, NA
*cognitive↑, *cognitive∅, *AChE↓,
3803- Hup,    Huperzine A and Its Neuroprotective Molecular Signaling in Alzheimer’s Disease
- Review, AD, NA
*AChE↓, *neuroP↑, *BBB↑, *Half-Life↑, *cognitive↑, *Dose↝, *BACE↓, *IronCh↑, *TfR1/CD71↓, *ROS↓,
3802- Hup,    New insights into huperzine A for the treatment of Alzheimer's disease
- Review, AD, NA
*AChE↓, *neuroP↑,
3801- Hup,    An update on huperzine A as a treatment for Alzheimer's disease
- Review, AD, NA
*AChE↓, *antiOx↑, *neuroP↑,
3800- Hup,    Role of huperzine a in the treatment of Alzheimer's disease
- Review, AD, NA
*AChE↓, *neuroP↑, *cognitive↑,
3799- Hup,    The use of Huperzia species for the treatment of Alzheimer's disease
- NA, AD, NA
*antiOx↑, *Inflam↓, *AChE↓,
4210- Hup,    A Synopsis of Multitarget Potential Therapeutic Effects of Huperzine A in Diverse Pathologies–Emphasis on Alzheimer’s Disease Pathogenesis
- Review, AD, NA
*neuroP↑, *AChE↓, *Ach↑, *memory↑, *NGF↑, *BDNF↑,
2916- LT,    Antioxidative and Anticancer Potential of Luteolin: A Comprehensive Approach Against Wide Range of Human Malignancies
- Review, Var, NA - Review, AD, NA - Review, Park, NA
proCasp9↓, CDC2↓, CycB/CCNB1↓, Casp9↑, Casp3↑, Cyt‑c↑, cycA1/CCNA1↑, CDK2↓, APAF1↑, TumCCA↑, P53↑, BAX↑, VEGF↓, Bcl-2↓, Apoptosis↑, p‑Akt↓, p‑EGFR↓, p‑ERK↓, p‑STAT3↓, cardioP↑, Catalase↓, SOD↓, *BioAv↓, *antiOx↑, *ROS↓, *NO↓, *GSTs↑, *GSR↑, *SOD↑, *Catalase↑, *lipid-P↓, PI3K↓, Akt↓, CDK2↓, BNIP3↑, hTERT/TERT↓, DR5↑, Beclin-1↑, TNF-α↓, NF-kB↓, IL1↓, IL6↓, EMT↓, FAK↓, E-cadherin↑, MDM2↓, NOTCH↓, MAPK↑, Vim↓, N-cadherin↓, Snail↓, MMP2↓, Twist↓, MMP9↓, ROS↑, MMP↓, *AChE↓, *MMP↑, *Aβ↓, *neuroP↑, Trx1↑, ROS↓, *NRF2↑, NRF2↓, *BBB↑, ChemoSen↑, GutMicro↑,
5252- MAG,    Insights on the Multifunctional Activities of Magnolol
- Review, Var, NA
BioAv↓, *Inflam↓, *Bacteria↓, *antiOx↑, *neuroP↑, *cardioP↑, CYP1A1↓, *PPARγ↑, *NF-kB↓, *COX2↓, *iNOS↓, *ROS↓, Apoptosis↑, TumCCA↑, cycD1/CCND1↓, cycA1/CCNA1↓, CDK2↓, P21↑, TumCG↓, TumCMig↓, TumCI↓, Ki-67↓, PCNA↓, MMP2↓, MMP9↓, MMP7↓, DNAdam↑, MMP↓, TumCP↓, selectivity↑, PI3K↓, Akt↓, H2O2↓, Hif1a↓, *BDNF↑, *NRF2↑, *AChE↑,
3900- MCT,    Coconut (Cocos nucifera) Ethanolic Leaf Extract Reduces Amyloid-β (1-42) Aggregation and Paralysis Prevalence in Transgenic Caenorhabditis elegans Independently of Free Radical Scavenging and Acetylcholinesterase Inhibition
- in-vitro, AD, NA
*ROS↑, *AChE↓, *Aβ↓,
3745- MFrot,  MF,    The neurobiological foundation of effective repetitive transcranial magnetic brain stimulation in Alzheimer's disease
- Review, AD, NA
*neuroP↑, *ROS↓, *Inflam↓, *5HT↑, *cFos↑, *Aβ↓, *memory↑, *BDNF↑, *Ach↑, *AChE↓, *cognitive↑, *BDNF↑, *NGF↑, *β-catenin/ZEB1↑, *p‑Akt↓, *mTOR↓, *MMP1↓, *MMP9↓, *MMP-10↓, *TIMP1↑, *TIMP2↑,
4226- Moringa,    The Oil Formulation Derived from Moringa Oleifera Seeds Ameliorates Behavioral Abnormalities in Water-immersion Restraint Stress Mouse Model
- in-vivo, NA, NA
*neuroP↑, *Mood↑, *BDNF↑, *AChE↓, *MDA↓,
3838- Moringa,    Characterization, Large-Scale HSCCC Separation and Neuroprotective Effects of Polyphenols from Moringa oleifera Leaves
- in-vitro, AD, PC12 - Review, Stroke, NA
*Inflam↓, *neuroP↑, *antiOx↑, *ROS↓, *memory↑, *MDA↓, *AChE↓, *SOD↑, *Catalase↑, *eff↑,
3835- Moringa,    Moringa Oleifera Alleviates Aβ Burden and Improves Synaptic Plasticity and Cognitive Impairments in APP/PS1 Mice
- in-vivo, AD, NA
*antiOx↑, *Inflam↓, *AChE↓, *neuroP↑, *Mood↑, *cognitive↑, *memory↑, *Aβ↓, *BACE↓, *AEP↓, *IDE↑, *NEP↑, *LRP1↑, *PSD95↑, *STEP↓, *APP↓,
3840- Moringa,    Moringa oleifera Mitigates Memory Impairment and Neurodegeneration in Animal Model of Age-Related Dementia
- in-vivo, AD, NA
*antiOx↑, *memory↑, *neuroP↑, *MDA↓, *AChE↓, *SOD↑, *Catalase↑, *cognitive↑, *ROS↓, *Ach↑,
3843- Moringa,    Moringa oleifera-supplemented diet protect against cortico-hippocampal neuronal degeneration in scopolamine-induced spatial memory deficit in mice: role of oxido-inflammatory and cholinergic neurotransmission pathway
- in-vivo, AD, NA
*memory↑, *ROS↓, *Ach↑, *AChE↓,
6042- Moringa,  CGA,    Characterization of the Anticholinesterase and Antioxidant Properties of Phytochemicals from Moringa oleifera as a Potential Treatment for Alzheimer’s Disease
- Analysis, AD, NA
*AChE↓, *BChE↓, *antiOx↑,
3848- MSM,    Modulatory effect of methylsulfonylmethane against BPA/γ-radiation induced neurodegenerative alterations in rats: Influence of TREM-2/DAP-12/Syk pathway
- in-vitro, AD, NA
*ROS↓, *Inflam↓, *neuroP↑, *ER(estro)↑, *NRF2↑, *HO-1↑, *Trx1↑, *TXNIP↓, *MDA↓, *NOX↓, *GSH↑, *GPx↑, *SOD↑, *Catalase↑, *BDNF↑, *AChE↓, *p‑tau↓, *Aβ↓,
3811- mushLions,    Hericium erinaceus (Bull.) Pers. Ethanolic Extract with Antioxidant Properties on Scopolamine-Induced Memory Deficits in a Zebrafish Model of Cognitive Impairment
- in-vitro, NA, NA
*memory↑, *BBB↑, *GSH↑, *AChE↓, *MDA↓,
3809- mushLions,    The Monkey Head Mushroom and Memory Enhancement in Alzheimer's Disease
- Review, NA, NA
*cognitive↑, *Apoptosis↓, *Aβ↓, *AChE↓, *BACE↓,
3759- NarG,  RT,  CGA,  RosA,    Polyphenols as acetylcholinesterase inhibitors: Structural specificity and impact on human disease
- Review, AD, NA
*AChE↓, *other↓, *other↓,

Showing Research Papers: 51 to 100 of 142
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 142

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

Catalase↓, 1,   CYP1A1↓, 1,   H2O2↓, 1,   NRF2↓, 1,   ROS↓, 1,   ROS↑, 2,   SOD↓, 1,   Trx1↑, 1,  

Mitochondria & Bioenergetics ⓘ

CDC2↓, 1,   MMP↓, 2,  

Core Metabolism/Glycolysis ⓘ

cMyc↓, 1,  

Cell Death ⓘ

Akt↓, 3,   p‑Akt↓, 1,   APAF1↑, 1,   Apoptosis↑, 3,   BAX↑, 4,   Bcl-2↓, 4,   Casp3↑, 2,   Casp9↑, 2,   proCasp9↓, 1,   Cyt‑c↑, 1,   DR5↑, 1,   hTERT/TERT↓, 1,   iNOS↓, 1,   MAPK↑, 1,   MDM2↓, 1,  

Transcription & Epigenetics ⓘ

cJun↓, 1,   other↑, 1,  

Protein Folding & ER Stress ⓘ

ER Stress↑, 1,  

Autophagy & Lysosomes ⓘ

Beclin-1↑, 1,   BNIP3↑, 1,  

DNA Damage & Repair ⓘ

DNAdam↑, 2,   P53↓, 1,   P53↑, 2,   PCNA↓, 1,  

Cell Cycle & Senescence ⓘ

CDK2↓, 3,   CDK4↓, 1,   cycA1/CCNA1↓, 1,   cycA1/CCNA1↑, 1,   CycB/CCNB1↓, 2,   cycD1/CCND1↓, 2,   P21↑, 1,   TumCCA↑, 3,  

Proliferation, Differentiation & Cell State ⓘ

ALDH↓, 1,   CD133↑, 1,   cFos↓, 1,   CSCs↓, 1,   EMT↓, 2,   p‑ERK↓, 1,   NOTCH↓, 1,   PI3K↓, 3,   STAT↓, 1,   p‑STAT3↓, 1,   TumCG↓, 2,  

Migration ⓘ

5LO↓, 1,   E-cadherin↑, 1,   FAK↓, 1,   Ki-67↓, 1,   MMP2↓, 2,   MMP7↓, 1,   MMP9↓, 3,   N-cadherin↓, 1,   PKCδ↓, 1,   Snail↓, 1,   TumCI↓, 2,   TumCMig↓, 2,   TumCP↓, 1,   TumMeta↓, 1,   Twist↓, 1,   Vim↓, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 1,   EGFR↓, 1,   p‑EGFR↓, 1,   Hif1a↓, 1,   VEGF↓, 2,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   IL1↓, 2,   IL12↓, 1,   IL2↓, 1,   IL6↓, 2,   IL8↓, 1,   JAK↓, 1,   MCP1↓, 1,   NF-kB↓, 2,   TNF-α↓, 1,  

Protein Aggregation ⓘ

XO↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 1,   ChemoSen↑, 2,   DDS↑, 1,   eff↑, 2,   selectivity↑, 1,  

Clinical Biomarkers ⓘ

EGFR↓, 1,   p‑EGFR↓, 1,   GutMicro↑, 1,   hTERT/TERT↓, 1,   IL6↓, 2,   Ki-67↓, 1,  

Functional Outcomes ⓘ

AntiTum↑, 1,   cardioP↑, 1,  
Total Targets: 99

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 24,   Catalase↑, 10,   GPx↑, 4,   GSH↑, 10,   GSR↑, 1,   GSSG↓, 1,   GSTs↑, 1,   HO-1↑, 8,   HO-2↓, 1,   lipid-P↓, 5,   lipid-P↑, 1,   MDA↓, 9,   MDA↑, 1,   MPO↓, 1,   NQO1↑, 1,   NRF2↓, 1,   NRF2↑, 7,   ROS↓, 25,   ROS↑, 1,   mt-ROS↓, 1,   SIRT3↑, 1,   SOD↓, 1,   SOD↑, 13,   Thiols↑, 1,   Trx1↑, 1,  

Metal & Cofactor Biology ⓘ

Ferritin↑, 1,   IronCh↑, 5,   TfR1/CD71↓, 1,  

Mitochondria & Bioenergetics ⓘ

MMP↓, 1,   MMP↑, 4,   PGC-1α↑, 2,  

Core Metabolism/Glycolysis ⓘ

AMPK↑, 2,   glucose↓, 2,   GlucoseCon↑, 1,   GLUT2↑, 1,   LDL↓, 2,   NADPH↓, 1,   PPARγ↑, 3,   SIRT1↑, 2,  

Cell Death ⓘ

Akt↑, 1,   p‑Akt↓, 2,   p‑Akt↑, 1,   Apoptosis↓, 2,   BAX↑, 1,   Bcl-2↑, 2,   Casp↓, 1,   Casp3↓, 1,   iNOS↓, 3,  

Transcription & Epigenetics ⓘ

Ach↑, 8,   other↓, 8,   other↑, 1,  

Protein Folding & ER Stress ⓘ

CHOP↓, 1,   GRP78/BiP↓, 1,  

DNA Damage & Repair ⓘ

DNAdam↓, 1,   P53↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

cFos↑, 1,   ERK↓, 1,   ERK↑, 1,   GSK‐3β↓, 3,   mTOR↓, 2,   PI3K↑, 1,  

Migration ⓘ

APP↓, 2,   Ca+2↓, 1,   CDK5↓, 2,   LRP1↑, 1,   MMP-10↓, 1,   MMP1↓, 1,   MMP9↓, 1,   TIMP1↑, 1,   TIMP2↑, 1,   TXNIP↓, 2,   β-catenin/ZEB1↑, 2,  

Angiogenesis & Vasculature ⓘ

NO↓, 2,   NO↑, 1,  

Barriers & Transport ⓘ

BBB↑, 7,   GastroP↑, 1,   GLUT3↑, 1,   GLUT4↑, 1,  

Immune & Inflammatory Signaling ⓘ

COX2?, 1,   COX2↓, 4,   CRP↓, 1,   IL1↓, 1,   IL10↓, 1,   IL10↑, 1,   IL12↓, 1,   IL17↓, 1,   IL1β↓, 3,   IL1β↑, 1,   IL23↓, 1,   IL4↑, 1,   IL6↓, 2,   Imm↑, 1,   Inflam↓, 18,   MCP1↓, 1,   NF-kB↓, 5,   TNF-α↓, 7,  

Cellular Microenvironment ⓘ

NOX↓, 1,  

Synaptic & Neurotransmission ⓘ

5HT↑, 2,   AChE↓, 48,   AChE↑, 1,   AChE∅, 1,   BChE↓, 5,   BChE∅, 1,   BDNF↑, 7,   ChAT↑, 1,   MAOA↓, 1,   MAOA↝, 1,   NGF↑, 2,   PSD95↑, 1,   tau↓, 2,   p‑tau↓, 7,  

Protein Aggregation ⓘ

AEP↓, 1,   AGEs↓, 1,   Aβ↓, 22,   BACE↓, 7,   IDE↑, 1,   MAOB↓, 2,   NEP↑, 1,   NLRP3↓, 2,   XO↓, 1,  

Hormonal & Nuclear Receptors ⓘ

ER(estro)↑, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 2,   BioAv↑, 3,   BioAv↝, 1,   Dose↝, 2,   eff↑, 2,   Half-Life↑, 1,  

Clinical Biomarkers ⓘ

BMD↑, 1,   CRP↓, 1,   Ferritin↑, 1,   GutMicro↑, 2,   IL6↓, 2,   NOS2↓, 1,  

Functional Outcomes ⓘ

AntiAge↑, 1,   AntiCan↑, 1,   AntiDiabetic↑, 3,   cardioP↑, 2,   cognitive↑, 15,   cognitive∅, 2,   hepatoP↑, 3,   memory↑, 16,   Mood↑, 2,   motorD↑, 1,   neuroP↑, 28,   Obesity↓, 1,   OS↑, 1,   STEP↓, 1,   toxicity?, 1,   toxicity↓, 1,   Wound Healing↑, 1,  

Infection & Microbiome ⓘ

Bacteria↓, 1,  
Total Targets: 151

Scientific Paper Hit Count for: AChE, acetylcholinesterase
17 Curcumin
11 Chlorogenic acid
10 Huperzine A/Huperzia serrata
10 Rosmarinic acid
9 Crocetin
8 Ferulic acid
8 Thymoquinone
7 Berberine
6 Quercetin
6 Moringa oleifera
5 Caffeic acid
5 Carvacrol
5 Salvia officinalis
5 Shankhpushpi
4 Aromatherapy
4 Selenium NanoParticles
4 Piperine
4 Silymarin (Milk Thistle) silibinin
3 Boswellia (frankincense)
3 Galantamine
3 Resveratrol
3 Naringin
2 Alpha-Lipoic-Acid
2 Apigenin (mainly Parsley)
2 Ashwagandha(Withaferin A)
2 EGCG (Epigallocatechin Gallate)
2 Luteolin
2 beta-carotene(VitA)
2 Bacopa monnieri
2 Boron
2 Rutin
2 D-limonene
2 Mushroom Lion’s Mane
1 Anethole/trans-Anethole
1 Fennel Oil/Foeniculum vulgare
1 Astaxanthin
1 Biochanin A
1 Caffeic Acid Phenethyl Ester (CAPE)
1 Chrysin
1 Cinnamon
1 Vitamin E
1 Rivastigmine
1 Ginger/6-Shogaol/Gingerol
1 Capsaicin
1 Ellagic acid
1 Ginkgo biloba
1 Honokiol
1 Magnolol
1 MCToil
1 Magnetic Field Rotating
1 Magnetic Fields
1 Methylsulfonylmethane
1 Propolis -bee glue
1 Carnosic acid
1 Caffeine
1 Selenium
1 Sesame seeds and Oil
1 Chemotherapy
1 Safflower yellow
1 Thymol-Thymus vulgaris
1 Zinc
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1329  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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