BACE Cancer Research Results

BACE, β-site APP-cleaving enzyme: Click to Expand ⟱
Source:
Type:
BACE stands for β-site APP-cleaving enzyme, also known as β-secretase. It plays a central role in the pathogenesis of Alzheimer’s disease by initiating the production of amyloid-β (Aβ) peptides, the primary components of amyloid plaques found in the brains of individuals with AD.
-inhibiting BACE1 reduces Aβ production.
Scientific Papers found: Click to Expand⟱
4870- Uro,    Urolithin A attenuates memory impairment and neuroinflammation in APP/PS1 mice
- in-vivo, AD, NA
*cognitive↑, *Apoptosis↓, *neuroP↑, *Aβ↓, *AMPK↑, *NF-kB↓, *MAPK↓, *BACE↑, *neuroG↑, *Inflam↓, *memory↑,
4313- VitA,RetA,    Unraveling the molecular mechanisms of vitamin deficiency in Alzheimer's disease pathophysiology
- Review, AD, NA
*neuroP↑, memory↑, *Inflam↓, *neuroG↑, *cognitive↑, *Aβ↓, p‑tau↓, *BACE↓,
4314- VitB1/Thiamine,    Unraveling the molecular mechanisms of vitamin deficiency in Alzheimer's disease pathophysiology
- Review, AD, NA
*Risk↓, *GlucoseCon↑, *cognitive↑, *ATP↑, *ROS↓, *NADPH↑, *Aβ↓, *APP↓, *BACE↓,
4037- VitB12,  FA,    Mechanistic Link between Vitamin B12 and Alzheimer’s Disease
- Review, AD, NA
*antiOx↑, *ROS↓, *GSH↑, *Inflam↓, *IL6↓, *TNF-α↓, *other↑, *other↑, *other↑, *Aβ↓, *memory↑, *p‑tau↓, *APP↓, *BACE↓, *ATP↑, *neuroP↑,
4034- VitB3,    Nicotinamide riboside restores cognition through an upregulation of proliferator-activated receptor-γ coactivator 1α regulated β-secretase 1 degradation and mitochondrial gene expression in Alzheimer’s mouse models
- in-vivo, AD, NA
*cognitive↑, *NAD↑, *BACE↓, *Aβ↓, *PGC-1α↑,
4033- VitB3,    Can nicotinamide riboside protect against cognitive impairment?
- in-vivo, AD, NA
*memory↑, *DNAdam↓, *Inflam↓, *Apoptosis↓, *cognitive↑, *BACE↓, *Aβ↓, *BBB↑, *GutMicro↑, *eff↑,
3921- VitD3,  RES,    Vitamin D Combined with Resveratrol Prevents Cognitive Decline in SAMP8 Mice
- in-vivo, AD, NA
*cognitive↑, *Aβ↓, *BACE↓, *p‑tau↓, *p‑CREB↑, *p‑NF-kB↓, *neuroP↑,

Showing Research Papers: 51 to 57 of 57
Prev Page 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 57

Pathway results for Effect on Cancer / Diseased Cells:


Synaptic & Neurotransmission(tgid=18) ⓘ

p‑tau↓, 1,  

Functional Outcomes(tgid=23) ⓘ

memory↑, 1,  
Total Targets: 2

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   GSH↑, 1,   ROS↓, 2,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↑, 2,   PGC-1α↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 1,   p‑CREB↑, 1,   GlucoseCon↑, 1,   NAD↑, 1,   NADPH↑, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 2,   MAPK↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↑, 3,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

neuroG↑, 2,  

Migration(tgid=13) ⓘ

APP↓, 2,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

IL6↓, 1,   Inflam↓, 4,   NF-kB↓, 1,   p‑NF-kB↓, 1,   TNF-α↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

p‑tau↓, 2,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 7,   BACE↓, 6,   BACE↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

eff↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

GutMicro↑, 1,   IL6↓, 1,  

Functional Outcomes(tgid=23) ⓘ

cognitive↑, 6,   memory↑, 3,   neuroP↑, 4,   Risk↓, 1,  
Total Targets: 33

Scientific Paper Hit Count for: BACE, β-site APP-cleaving enzyme
3 Berberine
3 Curcumin
3 Huperzine A/Huperzia serrata
3 Emodin
3 Resveratrol
3 Urolithin
2 EGCG (Epigallocatechin Gallate)
2 Biochanin A
2 Cichoric acid / Chicoric acid
2 Ginseng
2 Hydrogen Gas
2 Moringa oleifera
2 Quercetin
2 Sulforaphane (mainly Broccoli)
2 Vitamin B3,Niacin
1 1,8-Cineole
1 Anthocyanins
1 Apigenin (mainly Parsley)
1 Aromatherapy
1 Ashwagandha(Withaferin A)
1 Astaxanthin
1 beta-carotene(VitA)
1 Brucea javanica
1 Bacopa monnieri
1 borneol
1 α-Bisabolol / Chamomile oil
1 Celastrol
1 Echinacea
1 Ellagic acid
1 Ferulic acid
1 flavonoids
1 Luteolin
1 Lycopene
1 Magnetic Fields
1 Mushroom Lion’s Mane
1 EMF
1 Thymoquinone
1 Vitamin A, Retinoic Acid
1 Vitamin B1/Thiamine
1 Vitamin B12
1 Folic Acid, Vit B9
1 Vitamin D3
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1349  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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