BDNF Cancer Research Results

BDNF, brain-derived neurotrophic factor: Click to Expand ⟱
Source:
Type:
Brain-Derived Neurotrophic Factor (BDNF) is a key neurotrophin (a type of growth factor) involved in brain health, and its role in Alzheimer’s Disease (AD) has been extensively studied.
-AD patients often have lower BDNF levels in key brain regions, such as the hippocampus and cortex.
-This reduction correlates with cognitive decline and brain atrophy.
-BDNF normally protects neurons from Aβ toxicity
-Exercise and cognitive training have been shown to boost BDNF levels and may slow cognitive decline.
- natural compounds (like curcumin or flavonoids) may also upregulate BDNF.
Scientific Papers found: Click to Expand⟱
4175- CUR,    Effects of curcumin on learning and memory deficits, BDNF, and ERK protein expression in rats exposed to chronic unpredictable stress
- in-vivo, AD, NA
*BDNF↑, *ERK↑,
4171- CUR,    Curcumin produces neuroprotective effects via activating brain-derived neurotrophic factor/TrkB-dependent MAPK and PI-3K cascades in rodent cortical neurons
- in-vivo, Nor, NA
*BDNF↑, *TrkB↑, *CREB↑, *Mood↑, *neuroP↑,
3795- CUR,    Curcumin: A Golden Approach to Healthy Aging: A Systematic Review of the Evidence
- Review, AD, NA
*antiOx↑, *Inflam↓, *AntiAge↑, *AMPK↑, *SIRT1↑, *NF-kB↓, *mTOR↓, *NLRP3↓, *NADPH↓, *ROS↓, *COX2/PTGS2↓, *MCP1/CCL2↓, *IL1β↓, *IL17↓, *IL23↓, *TNF-α↓, *MPO↓, *IL10↑, *lipid-P↓, *SOD↑, *Aβ↓, *p‑tau↓, *GSK‐3β↓, *CDK5↓, *TXNIP↓, *NRF2↑, *NQO1↑, *HO-1↑, *OS↑, *memory↑, *BDNF↑, *neuroP↑, *BACE/β-secretase↓, *AChE↓, *LDL↓,
3797- CUR,    Curcumin reverses cognitive deficits through promoting neurogenesis and synapse plasticity via the upregulation of PSD95 and BDNF in mice
- in-vitro, AD, NA
*cognitive↑, *BDNF↑, *PSD95↑, *memory↑,
4333- Cyste,    Cystamine protects from 3-nitropropionic acid lesioning via induction of nf-e2 related factor 2 mediated transcription
- vitro+vivo, AD, NA
*NRF2↑, *ARE↑, *neuroP↑, *BDNF↑, *GSH↑,
4331- Cyste,    Cystamine and cysteamine increase brain levels of BDNF in Huntington disease via HSJ1b and transglutaminase
- in-vivo, HD, NA - NA, AD, NA
*BDNF↑, *neuroP↑, *TG2/TGase↓,
6259- Cyste,    Therapeutic Applications of Cysteamine and Cystamine in Neurodegenerative and Neuropsychiatric Diseases
- Review, AD, NA - Review, Park, NA
*ROS↓, *neuroP↑, *BDNF↑, *NRF2↑, *BBB↑, *HSPs↑, *GSH↑, *TG2/TGase↓, Aβ↓,
4178- DHA,    The salutary effects of DHA dietary supplementation on cognition, neuroplasticity, and membrane homeostasis after brain trauma
- in-vivo, AD, NA
*BDNF↑, *CREB↑, *cognitive↑, *SOD↑,
4177- DHA,    Dietary omega-3 fatty acids normalize BDNF levels, reduce oxidative damage, and counteract learning disability after traumatic brain injury in rats
- in-vivo, AD, NA
*BDNF↑, *CREB↑, *ROS↓, *cognitive↑,
4256- dietMed,    Association between Mediterranean dietary pattern with sleep duration, sleep quality and brain derived neurotrophic factor (BDNF) in Iranian adults
- Study, Nor, NA
*Sleep↑, *BDNF↑,
4180- dietSTF,    Brain-derived neurotrophic factor, but not body weight, correlated with a reduction in depression scale scores in men with metabolic syndrome: a prospective weight-reduction study
- Human, Obesity, NA
*BDNF↑,
4159- dietSTF,  2DG,  CRMs,    Meal size and frequency affect neuronal plasticity and vulnerability to disease: cellular and molecular mechanisms
- Review, AD, NA
*BDNF↑, *HSPs↑, *eff↑,
8844- DIM,  I3C,    Unveiling the Multifaceted Pharmacological Actions of Indole-3-Carbinol and Diindolylmethane: A Comprehensive Review
- Review, Var, NA - Review, AD, NA - Review, Stroke, NA
*antiOx↑, *Inflam↓, *Apoptosis↓, *Imm↝, *BioAv↝, *Half-Life↝, *PKCδ↓, *TGF-β1↓, *PPARγ↓, *CEBPA↓, *FABP4↓, *AMPKα↑, *MCP1/CCL2↓, *IL6↓, *TNF-α↓, *Akt↑, *Inflam↓, *TMAO↓, *SREBF2⇅, *memfluid↑, *GutMicro↑, *Obesity↓, *hepatoP↑, *neuroP↑, *AntiAg↓, *Stroke↓, *AntiAg↓, *HDAC↑, *IL1β↓, *IL6↓, *iNOS↓, *IL4↑, *IL10↑, *Synergy↑, *compI↑, *ROS↓, *AChE↓, *BChE↓, *MAOA↓, *MAOB↓, *cognitive↑, *Analgesic↑, *Pain↓, *BDNF↑, *TrkB↑, *Akt↑, *antiOx↑, *Apoptosis↓, *cardioP↑, *chemoP↑, *AntiThr↑, *uPA↑, *NRF2↑, *ARE↑, *HO-1↑, *Bacteria↓, *TOP1↓, *AntiFungal↑, *AntiViral↑, *radioP↑, *Synergy↑, *hepatoP↑, *Diar↓, *ChemoSen↑, *Telomerase↓, *BioAv↓,
4255- EA,    Effects of nutritional interventions on BDNF concentrations in humans: a systematic review
- Review, AD, NA
*BDNF↑,
4254- EA,    Chronic administration of ellagic acid improved the cognition in middle-aged overweight men
- Human, Obesity, NA
*LDL↓, *HDL↑, *BDNF↑, *cognitive↑,
4253- EA,    The effects of Ellagic acid supplementation on neurotrophic, inflammation, and oxidative stress factors, and indoleamine 2, 3-dioxygenase gene expression in multiple sclerosis patients with mild to moderate depressive symptoms: A randomized, triple-blind, placebo-controlled trial
- Human, MS, NA - NA, IBD, NA
*Mood↑, *BDNF↑, *5HT↑, *antiOx↑, *Inflam↓, *AntiCan↑, *QoL↑, *neuroP↑, *cognitive↑, *memory↑, *Dose↝,
4252- EA,    Effect of ellagic acid on BDNF/PI3K/AKT-mediated signaling pathways in mouse models of depression
- in-vivo, AD, NA
*BDNF↑, *p‑AKT1↑,
4152- EGCG,    Green tea catechins potentiate the neuritogenic action of brain-derived neurotrophic factor: role of 67-kDa laminin receptor and hydrogen peroxide
- in-vitro, AD, NA
*BDNF↑,
6819- EMD,    Recent advances in the therapeutic potential of emodin for human health
- Review, Nor, NA
AntiCan↑, *AntiDiabetic↑, *neuroP↑, *Inflam↓, *antiOx↑, *BioAv↓, *BioAv↑, *SOD↑, *GPx↑, *GSH↑, *NRF2↑, *ROS↓, *lipid-P↓, *Cyt‑c↓, *BAX↓, *Bcl-2↓, *iNOS↓, *NO↓, *IL6↓, *IL10↓, *IL17↓, *IFN-γ↓, *NF-kB↓, *LC3II↓, *Akt↓, *Beclin-1/ATG6↓, *AMPK↓, *TNF-α↓, *PGE2↓, *Apoptosis↓, *Casp3↓, *Casp9↓, *P53↓, *P21↓, *NAD↓, *ATP↓, *CHOP/DDIT3↓, *GADD34↓, *ATF4↓, tumCV↓, Apoptosis↑, TumCG↓, TumCI↓, TumMeta↓, CSCs↓, NOTCH1↓, STAT3↓, Synergy↑, miR-34a↓, *neuroP↑, *BDNF↓, *hepatoP↑, *ALAT↓, *AST↓, TG/TAG↓, ROS↑, Slug↓, EMT↓, Glycolysis↓, ChemoSen↑, P-gp/ABCB1↓, Ki-67↓, PCNA↓, ER Stress↑, TRIB3↑, NF-kB↑, TumMeta↑, *Imm↓, *toxicity↝,
6378- Eug,    Effects of Eugenol on the Central Nervous System: Its Possible Application to Treatment of Alzheimer's Disease, Depression, and Parkinson's Disease
- Review, AD, NA
*other↑, *Aβ↓, *BDNF↑, *MAOA↑, *toxicity↓, *Ca+2↓, *antiOx↑, *ROS↓, *lipid-P↓, *neuroP↑, *PGE2↓, *COX2/PTGS2↓, *5LO↓,
6377- Eug,    Pharmacological Properties and Health Benefits of Eugenol: A Comprehensive Review
- Review, Var, NA - Review, AD, NA
*Inflam↓, *Bacteria↓, ChemoSen↑, *selectivity↑, ROS⇅, TumCG↓, MMP↓, antiOx⇅, *antiOx↑, *BBB↑, *neuroP↑, *BDNF↑, *Aβ↓, *Ca+2↓, *5LO↓, *MAOA↓, other↑,
4155- Ex,    Prior regular exercise reverses the decreased effects of sleep deprivation on brain-derived neurotrophic factor levels in the hippocampus of ovariectomized female rats
- in-vivo, AD, NA
*BDNF↑,
4144- Ex,    Exploring the impact of exercise-induced BDNF on neuroplasticity in neurodegenerative and neuropsychiatric conditions
- Review, AD, NA
*BDNF↑, *memory↑, *neuroP↑, *cognitive↑,
4143- Ex,    Brain-Derived Neurotrophic Factor: A Connecting Link Between Nutrition, Lifestyle, and Alzheimer’s Disease
- Review, AD, NA
*BDNF↑, *Synergy↑, *other↓, *eff↑,
4174- Ex,    Exercise-Mediated Neurogenesis in the Hippocampus via BDNF
- Review, Nor, NA
*neuroP↑, *cognitive↑, *memory↑, *BDNF↑, *neuroG↑,
4142- Ex,    Mechanisms of the Beneficial Effects of Exercise on Brain-Derived Neurotrophic Factor Expression in Alzheimer’s Disease
- Review, AD, NA
*BDNF↑, *cognitive↑,
4141- Ex,    Effects of exercise on brain-derived neurotrophic factor in Alzheimer's disease models: A systematic review and meta-analysis
- Review, AD, NA
*BDNF↑, *other↑, *eff↑,
4140- Ex,    Experimental and clinical evidence of physical exercise on BDNF and cognitive function: A comprehensive review from molecular basis to therapy
- Review, AD, NA
*BDNF↑, *cognitive↑,
4139- Ex,    Impact of physical exercise on the regulation of brain-derived neurotrophic factor in people with neurodegenerative diseases
- Review, AD, NA
*BDNF↑, *eff↑, *eff↑, *cognitive↑, *memory↑, *BrainVol↑, *TrkB↑, *GABA↑,
4145- Ex,    Effects of different physical activities on brain-derived neurotrophic factor: A systematic review and bayesian network meta-analysis
- Review, AD, NA
*BDNF↑, *eff↑,
4251- FA,    Antidepressant-Like Effect of Ferulic Acid via Promotion of Energy Metabolism Activity
- in-vivo, AD, NA
*BDNF↑, *ATP↑, *Mood↑,
4249- FA,    Folic acid supplementation during pregnancy prevents cognitive impairments and BDNF imbalance in the hippocampus of the offspring after neonatal hypoxia-ischemia
- in-vivo, AD, NA
*BDNF↑, *memory↑, *neuroP↑,
3715- FA,  CUR,  PS,    The Additive Effects of Low Dose Intake of Ferulic Acid, Phosphatidylserine and Curcumin, Not Alone, Improve Cognitive Function in APPswe/PS1dE9 Transgenic Mice
- in-vivo, AD, NA
*cognitive↑, *IL1β↓, *Ach↑, *Aβ↓, *p‑tau↓, *BDNF↑, *APP↓,
3714- FA,    Recent Advances in the Neuroprotective Properties of Ferulic Acid in Alzheimer's Disease: A Narrative Review
- Review, AD, NA
*antiOx↑, *Inflam↓, *neuroP↑, *NF-kB↓, *NLRP3↓, *iNOS↓, *COX2/PTGS2↓, *TNF-α↓, *IL1β↓, *VCAM-1↓, *ICAM-1↓, *p‑MAPK↓, *p38↓, *JNK↓, *IL6↓, *IL8↓, *hepatoP↑, *RenoP↑, *Catalase↑, *PPARγ↑, *ROS↓, *Fenton↓, *IronCh↑, *SOD↑, *MDA↓, *lipid-P↓, *NRF2↑, *HO-1↑, *ARE↑, *Bil↑, *radioP↑, *GCLC↑, *GCLM↑, *NQO1↑, *Half-Life↝, *GutMicro↑, *Aβ↓, *BDNF↑, *Ca+2↓, *lipid-P↓, *PGE2↓, *cognitive↑, *ChAT↑, *memory↑, *Dose↝, *toxicity↓,
2861- FIS,    The neuroprotective effects of fisetin, a natural flavonoid in neurodegenerative diseases: Focus on the role of oxidative stress
- Review, Nor, NA - Review, Stroke, NA - Review, Park, NA
*antiOx↑, *ROS↓, *neuroP↑, *NO↑, BioAv↝, *BBB↑, *toxicity↑, *eff↑, *GSH↑, *SOD↑, *Aβ↓, *12LOX↓, *COX2/PTGS2↓, *Catalase↑, *Inflam↓, *TNF-α↓, *IL6↑, *lipid-P↓, NF-kB↓, IL1β↓, NRF2↑, HO-1↑, GSTs↑, cognitive↑, *BDNF↑,
4250- Flav,    Dietary Flavonoids Interaction with CREB-BDNF Pathway: An 
Unconventional Approach for Comprehensive Management of Epilepsy
- Review, AD, NA
*ERK↑, *BDNF↑, *CREB↑,
6981- Form,    Formononetin: a review of its source, pharmacology, drug combination, toxicity, derivatives, and drug delivery systems
- Review, Var, NA - Review, AD, NA - Review, PSA, NA
BioAv↝, *memory↑, *ROS↓, *AChE↓, *NF-kB↓, *Keap1↝, *NRF2↑, *Inflam↓, *PGC-1α↝, *HO-1↓, *p‑tau↓, *cognitive↑, *BDNF↑, *5HT↑, *Stroke↓, *PARP1↓, *AIF↓, *Casp3↓, NP/CIPN↓, *neuroP↑, *NGF↑, *TNF-α↓, *IL1β↓, *IL18↓, *IL6↓, *VCAM-1↓, *pol-M2 MC↑, *hepatoP↑, *AST↓, *ALAT↓, *LC3II↑, *Beclin-1/ATG6↑, *p62↑, *COX2/PTGS2↑, *MMP↑, *ATP↑, *GSH↑, *Catalase↑, *GPx↑, *MDA↓, *antiPs↑, *AntiDiabetic↑, *glucose↓, *Insulin↑, *GutMicro↑, *Obesity↓, COX2/PTGS2↓, cycD1/CCND1↓, TumCCA↑, EGFR↓, GSK‐3β↑, Mcl-1↓, *toxicity↓, TumCP↓, Hif1a↓, VEGF↓, ERK↓, LAMs↓, Cyt‑c↑, Casp9↑, Casp3↑, PARP↑, TumCD↑, mitA↑, BACH1↓, P53↓, ROS↑, PD-1↓, NF-kB↓, *Bacteria↓, *AntiViral↑, *mt-ROS?, *PI3K↓, *chemoP↑, ChemoSen↑, Synergy↑, *toxicity↓, *BioAv↑, *BioAv↑, *Synergy↑, *antiAll↑,
8586- FS,    The Role of Flaxseed in Improving Human Health
- Review, Nor, NA
*lipidLev↓, *BP↓, *HOMA↓, *AntiCan↑, *antiOx↑, *BioAv↑, *Ingr↑, *Ingr↝, *Ingr↝, *GutMicro↑, *CompStab↝, *TC↓, *TG/TAG↓, *LDL↓, *HDL↑, *BP↓, *AntiDiabetic↑, *AntiCan↑, TumCD↑, selectivity↑, TumCP↓, Apoptosis↑, DNAdam↑, i-ROS↑, TumCCA↑, CDK2↓, CDK4↓, cycD1/CCND1↓, cycE/CCNE↓, ChemoSen↑, Synergy↑, *Inflam↓, *hs-CRP↓, *VCAM-1↓, *BDNF↑,
7040- GA,    Effects of gallic acid on acrylamide-induced endoplasmic reticulum stress, neuroinflammation and neuronal apoptosis in rats
- Trial, AD, NA
*SOD↑, *GSH↑, *GPx↑, *Catalase↑, *MDA↓, *TNF-α↓, *IL1β↓, *BAX↓, *Casp3↓, *BDNF↑, *NRF2↑, *HO-1↑,
4248- Gala,    Meta-analysis of randomized controlled trials of galantamine in schizophrenia: significant cognitive enhancement
- Review, AD, NA
*BDNF↑, *cognitive↑,
4245- GBE,    Standardized extract of Ginkgo biloba enhances memory persistence over time
- in-vivo, AD, NA
*memory↑, *BDNF↑, *CREB↓, *BDNF↑,
4244- GBE,    Effects of Six-Week Ginkgo biloba Supplementation on Aerobic Performance, Blood Pro/Antioxidant Balance, and Serum Brain-Derived Neurotrophic Factor in Physically Active Men
- Human, Nor, NA
*BDNF∅,
7670- GCL2505,    Effect of Continuous Ingestion of Bifidobacteria and Dietary Fiber on Improvement in Cognitive Function: A Randomized, Double-Blind, Placebo-Controlled Trial
- Trial, AD, NA
*cognitive↑, *GutMicro↑, *Inflam↓, *Dose↝, *BDNF∅,
7270- GGB,    Ginkgolide B protects hippocampal neurons from apoptosis induced by beta-amyloid 25-35 partly via up-regulation of brain-derived neurotrophic factor
- in-vivo, AD, NA
*BDNF↑, *Apoptosis↓, *neuroP↑,
7278- GGB,    Ginkgolide B: mechanisms of neurobiological effects, prospects for use in the therapy of Alzheimer's disease
- Review, AD, NA
*neuroP↑, *Aβ↓, *BDNF↑, *cognitive↑, *memory↑,
7217- GGB,    Role of Ginkgolides in the Inflammatory Immune Response of Neurological Diseases: A Review of Current Literatures
- Review, AD, NA
*eff↑, *AntiAg↑, *Apoptosis↓, *antiOx↑, *Inflam↓, *MAPK↓, *NF-kB↓, *PAF↓, *TLR1↓, *MyD88↓, *BDNF↑, *ROS↓, *PARP↓, *Cyt‑c↓,
4247- GI,    6-Shogaol from Dried Ginger Protects against Intestinal Ischemia/Reperfusion by Inhibiting Cell Apoptosis via the BDNF/TrkB/PI3K/AKT Pathway
- vitro+vivo, AD, NA
*BDNF↑, *TrkB↑, *PI3K↑, *Akt↑, *Apoptosis↓, *Inflam↓, *antiOx↑,
4246- GI,    Ginger oil-loaded transdermal adhesive patch treats post-traumatic stress disorder
- in-vivo, AD, NA
*BDNF↑, *Inflam↓,
4242- Gins,    Ginseng Extract G115 Attenuates Ethanol-Induced Depression in Mice by Increasing Brain BDNF Levels
- in-vivo, AD, NA
*BDNF↑, *Mood↑, *neuroP↑,
4243- Gins,    Effects of Ginseng on Neurological Disorders
- Review, Stroke, NA - Review, AD, NA - Review, Park, NA
*BDNF↑, *TrkB↑, *neuroP↑, *VEGF↑, *p‑tau↓, *memory↑,

Showing Research Papers: 51 to 100 of 245
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 245

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx⇅, 1,   Catalase↓, 2,   Catalase↑, 1,   GSH↓, 1,   GSTs↑, 1,   H2O2↓, 1,   HO-1↓, 1,   HO-1↑, 2,   MDA↓, 1,   MDA↑, 1,   NQO1↓, 1,   NRF2↓, 2,   NRF2↑, 1,   ROS↓, 1,   ROS↑, 6,   ROS⇅, 2,   i-ROS↑, 1,   SOD?, 1,   SOD↓, 2,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

mtDam↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 1,   Glycolysis↓, 1,   GSK‐3β↑, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 8,   BAX↑, 1,   BAX⇅, 1,   Bax:Bcl2↑, 1,   Bcl-2↓, 6,   Casp↑, 1,   Casp3↑, 5,   cl‑Casp3↑, 1,   Casp8↑, 2,   Casp9↑, 3,   cl‑Casp9↑, 1,   CellShr↑, 1,   Cyt‑c↑, 3,   DR5↑, 1,   FADD↑, 1,   Mcl-1↓, 1,   MOMP↑, 1,   PUMA↑, 1,   TNFR 1↑, 1,   TumCD↑, 2,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 3,   p‑Akt↓, 1,   Akt2↓, 1,   CaMKII ↑, 1,   p‑CREB↑, 1,   EGFR↓, 1,   ERK↓, 1,   MAPK↑, 1,   mTOR↓, 2,   P70S6K↓, 1,   PI3K↓, 4,   STAT3↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

cMyc↓, 1,   FOXO1↑, 1,   miR-34a↓, 1,   other↑, 2,   other↝, 1,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ER Stress↑, 1,   HSP70/HSPA5↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↑, 1,   TumAuto↑, 3,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 1,   DNAdam↑, 3,   P53↓, 2,   PARP↑, 1,   PCNA↓, 2,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 2,   CDK2↑, 1,   CDK4↓, 1,   ChrCon↑, 1,   cycA1/CCNA1↓, 1,   cycD1/CCND1↓, 5,   cycE/CCNE↓, 1,   Ki-67↓, 3,   mitA↑, 1,   P21↑, 1,   TumCCA↑, 10,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMP7/OP1↓, 2,   CSCs↓, 1,   Ki-67↓, 3,   NOTCH1↓, 1,   NOTCH1↑, 1,   TumCG↓, 6,   TumCP↓, 7,  

Migration(tgid=13) ⓘ

BACH1↓, 1,   COL1↓, 1,   E-cadherin↑, 1,   EMT↓, 3,   Fibronectin↓, 1,   LAMs↓, 1,   MMP2↓, 3,   MMP7↓, 1,   MMP9↓, 4,   MMP9↑, 1,   Slug↓, 2,   Snail↓, 1,   TET1↑, 1,   TRIB3↑, 1,   TumCI↓, 4,   TumCMig↓, 3,   TumMeta↓, 1,   TumMeta↑, 1,   Twist↓, 1,   Vim↓, 1,   Zeb1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 2,   Hif1a↓, 2,   VCAM-1↓, 1,   VEGF↓, 4,   VEGFR1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

MMP↓, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 2,   COX2/PTGS2↑, 1,   ICAM-1↓, 2,   IL1β↓, 1,   Imm↑, 1,   Inflam↓, 3,   pol-M1↑, 1,   MCP1/CCL2↓, 1,   NF-kB↓, 5,   NF-kB↑, 1,   PD-1↓, 1,   PSA↓, 1,   Th1 response↑, 1,   Th17↑, 1,   TRADD↑, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

BDNF↓, 1,   TrkB↓, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

PPARγ↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 4,   BioAv↝, 2,   CBR1↓, 1,   ChemoSen↑, 8,   CYP1A1↓, 1,   Dose↝, 3,   eff↑, 2,   Half-Life↓, 1,   Half-Life↑, 1,   P-gp/ABCB1↓, 1,   RadioS↑, 1,   selectivity↑, 4,   Synergy?, 1,   Synergy↑, 6,  

Clinical Biomarkers(tgid=22) ⓘ

EGFR↓, 1,   PSA↓, 1,   TG/TAG↓, 1,   TRIB3↑, 1,   Verbal↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 2,   cardioP↑, 1,   chemoP↑, 3,   cognitive↑, 3,   memory↑, 2,   neuroP↑, 1,   NP/CIPN↓, 1,   OS↑, 1,   radioP↑, 1,   RenoP↑, 1,   toxicity↓, 1,   TumVol↓, 2,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 4,  
Total Targets: 166

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↓, 1,   antiOx↑, 63,   ARE↑, 5,   Bil↑, 1,   Catalase↓, 1,   Catalase↑, 26,   Fenton↓, 1,   GCLC↑, 1,   GCLM↑, 1,   GPx↑, 20,   GPx4↑, 2,   GSH↑, 31,   GSR↑, 4,   GSTs↓, 1,   GSTs↑, 2,   H2O2↓, 1,   HDL↑, 2,   HO-1?, 1,   HO-1↓, 1,   HO-1↑, 25,   Iron↓, 2,   Keap1↝, 1,   lipid-P↓, 23,   lipid-P↑, 1,   MDA↓, 31,   MDA↑, 1,   MPO↓, 2,   MPOD↑, 1,   NOX↓, 2,   NQO1↑, 6,   Nrf1↑, 2,   NRF2↑, 47,   ONOO↓, 1,   ROS?, 1,   ROS↓, 86,   mt-ROS?, 1,   SOD↓, 2,   SOD↑, 39,   SOD1↑, 1,   SOD2↑, 1,   TAC↑, 6,   TBARS↓, 2,   TOS↓, 1,   Trx↑, 1,   Trx1↑, 2,  

Metal & Cofactor Biology(tgid=2) ⓘ

FTL↓, 1,   IronCh↑, 2,   TfR1/CD71↓, 2,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compI↑, 1,   Insulin↑, 1,   mtDam↓, 6,   OCR↑, 1,   PGC-1α↓, 3,   PGC-1α↑, 3,   PGC-1α↝, 1,   SIRT3↑, 2,   TFAM↑, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,   5LO↓, 5,   adiP↑, 1,   ALAT↓, 5,   AMPK↓, 1,   AMPK↑, 8,   AMPK↝, 1,   ATP↓, 1,   ATP↑, 5,   cAMP↑, 1,   FABP4↓, 1,   glucose↓, 2,   GSK‐3β↓, 12,   GSK‐3β↑, 2,   p‑GSK‐3β↑, 2,   H2S↑, 1,   LDL↓, 7,   lipidLev↓, 1,   NAD↓, 1,   NAD↑, 1,   NADPH↓, 2,   PFK↓, 1,   SIRT1↑, 15,   SREBF2⇅, 1,   SREBP1/SREBF1↓, 1,  

Cell Death(tgid=5) ⓘ

AIF↓, 1,   Apoptosis↓, 19,   ASC↓, 1,   BAX↓, 12,   Bax:Bcl2↓, 5,   Bcl-2↓, 2,   Bcl-2↑, 10,   Casp1↓, 1,   Casp3↓, 22,   Casp3↑, 1,   cl‑Casp3↓, 3,   Casp9↓, 3,   Casp9↑, 1,   Cyt‑c↓, 3,   Ferroptosis↓, 2,   iNOS↓, 9,   iNOS↑, 1,   p38↓, 2,   p‑p38↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 2,   Akt↑, 11,   Akt↝, 2,   p‑Akt↓, 4,   p‑Akt↑, 6,   p‑AKT1↑, 1,   AMPKα↑, 1,   CREB↓, 2,   CREB↑, 26,   CREB∅, 1,   p‑CREB↑, 13,   ERK↑, 10,   p‑ERK↓, 1,   p‑ERK↑, 1,   IκB↓, 1,   IκB↑, 1,   JNK↓, 5,   JNK↑, 1,   p‑JNK↓, 1,   MAPK↓, 5,   MAPK↑, 1,   MAPK↝, 1,   p‑MAPK↓, 1,   mTOR↓, 2,   mTOR↑, 3,   mTOR↝, 1,   p‑mTOR↓, 4,   p‑p70S6↓, 1,   PDGFR-BB↓, 1,   PDGFRB↓, 1,   PI3K↓, 1,   PI3K↑, 9,   PI3K↝, 1,   PKA↑, 2,   PKCδ↓, 1,   PKCδ↑, 1,   PP2A↑, 2,   p‑PTEN↓, 1,   PTP1B↓, 1,   STAT3↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 2,   ATF4↓, 2,   cJun↓, 1,   DNMT1↓, 1,   DNMT3A↓, 1,   FOXO↑, 1,   FOXO3↑, 3,   ac‑H3↑, 1,   ac‑H4↑, 1,   HDAC?, 1,   HDAC↓, 1,   HDAC↑, 1,   HDAC2↓, 3,   MEF2D↑, 1,   other↓, 3,   other↑, 6,   other↝, 1,   SOX2↑, 2,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 2,   ER Stress↓, 2,   GRP78/BiP↓, 2,   GRP78/BiP↑, 1,   HSP70/HSPA5↑, 1,   HSPs↑, 3,   PERK↓, 1,   UPR↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

autophagy↓, 1,   Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 4,   LC3II↓, 1,   LC3II↑, 3,   MitoP↑, 1,   p62↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 3,   P53↓, 1,   PARP↓, 1,   PARP1↓, 1,   Telomerase↓, 1,   TOP1↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK5↓, 1,   GADD34↓, 1,   Ki-67↑, 2,   P21↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMPs↑, 1,   CEBPA↓, 1,   cFos↑, 1,   CHIP↑, 1,   Diff↑, 1,   IGF-1↑, 1,   Ki-67↑, 2,   Nestin↑, 1,   neuroG↑, 6,   NOTCH1↑, 1,   TumCG↓, 1,   Wnt↑, 2,  

Migration(tgid=13) ⓘ

AntiAg↓, 2,   AntiAg↑, 1,   BACH1↓, 1,   Ca+2?, 1,   Ca+2↓, 5,   Ca+2↝, 1,   MMP-10↓, 1,   MMP1↓, 1,   MMP2↓, 1,   MMP9↓, 4,   MMPs↓, 1,   MUC1↑, 1,   TG2/TGase↓, 2,   TGF-β1↓, 1,   TIMP1↑, 1,   TIMP2↑, 1,   TumMeta↓, 1,   TXNIP↓, 2,   uPA↑, 1,   β-catenin/ZEB1↑, 4,   β-catenin/ZEB1↝, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

Endoglin↑, 1,   p‑eNOS↑, 1,   NO↓, 12,   NO↑, 1,   VCAM-1↓, 4,   VEGF↑, 6,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 24,   BBB↝, 1,   IBI↑, 1,   memfluid↑, 1,   MMP↑, 8,   OCLN↑, 1,   TRPM7↓, 1,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

AIF1/Iba-1↓, 3,   COX2/PTGS2↓, 18,   COX2/PTGS2↑, 1,   FOXP3↑, 1,   HMGB1↓, 1,   ICAM-1↓, 3,   IFN-γ↓, 2,   IL1↓, 2,   IL10↓, 2,   IL10↑, 6,   IL17↓, 3,   IL18↓, 1,   IL1β↓, 33,   IL23↓, 2,   IL33↓, 1,   IL4↑, 2,   IL6?, 1,   IL6↓, 30,   IL6↑, 2,   IL8↓, 6,   Imm↓, 1,   Imm↑, 1,   Imm↝, 1,   INF-γ↑, 1,   Inflam↓, 71,   pol-M2 MC↑, 1,   MCP1/CCL2↓, 3,   MIP‑1α/CCL3↓, 1,   MyD88↓, 2,   NeuroI↓, 8,   NF-kB↓, 36,   NF-kB↑, 1,   p‑NF-kB↓, 2,   NLRP3↓, 11,   PAF↓, 1,   PGE2↓, 6,   RAGE↓, 1,   TLR1↓, 1,   TLR4↓, 6,   TNF-α↓, 49,   TRAF6↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

GFAP↓, 5,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 11,   Ach↑, 11,   AChE↓, 32,   AChE↑, 1,   AChE↝, 1,   ADAM10↑, 1,   BChE↓, 4,   BDNF↓, 4,   BDNF↑, 233,   BDNF⇅, 1,   BDNF↝, 1,   BDNF∅, 8,   proBDNF↑, 2,   BrainVol↑, 1,   ChAT↑, 3,   GABA↓, 1,   GABA↑, 4,   GDNF↑, 1,   MAOA↓, 5,   MAOA↑, 1,   MAOB↓, 2,   NGF↑, 13,   PSD95↑, 14,   RELN↑, 1,   SNAP25↑, 2,   SYP↑, 2,   TrkB↓, 1,   TrkB↑, 25,   TrkB↝, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 2,   APOE4↑, 1,   APP↓, 6,   Aβ↓, 41,   Aβ↑, 1,   Aβ42↓, 4,   BACE/β-secretase↓, 15,   PSEN1/PS1↓, 1,   tau↓, 6,   p‑tau↓, 15,   β-Amyloid↓, 2,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

END↑, 1,   ER(estro)↓, 1,   ER(estro)↑, 2,   ERβ/ESR2↑, 1,   PPARα↑, 1,   PPARγ↓, 1,   PPARγ↑, 7,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 8,   BioAv↑, 8,   BioAv↝, 11,   BioEnh↑, 1,   ChemoSen↑, 1,   CompStab↝, 1,   CYP2D6↓, 1,   Dose?, 4,   Dose↑, 3,   Dose↝, 22,   eff↑, 17,   GSTA1↑, 1,   Half-Life↓, 2,   Half-Life↑, 1,   Half-Life↝, 3,   P450↓, 1,   selectivity↑, 1,   Synergy↑, 13,  

Clinical Biomarkers(tgid=22) ⓘ

ADC↓, 1,   ALAT↓, 5,   ALB↑, 1,   AST↓, 6,   Bil↑, 1,   BloodF↑, 1,   BMD↑, 1,   BP↓, 2,   BP∅, 1,   Calcium↑, 1,   creat↓, 1,   CRP↓, 1,   Hcy/homoC↓, 1,   HemoG↑, 1,   HOMA↓, 1,   hs-CRP↓, 1,   IL6?, 1,   IL6↓, 30,   IL6↑, 2,   NOS2↓, 1,   RAGE↓, 1,   TC↓, 2,   TG/TAG↓, 3,   TMAO↓, 1,   Urea↓, 1,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 1,   AntiAge↑, 3,   antiAll↑, 1,   AntiArt↑, 1,   AntiCan↑, 5,   antiCG↑, 1,   antiD↑, 2,   AntiDiabetic↑, 6,   AntiMyl↑, 1,   antiPs↑, 1,   AntiTum↑, 1,   ANXi↓, 2,   cardioP↑, 12,   chemoP↑, 2,   cognitive↑, 91,   cognitive∅, 3,   hepatoP↑, 15,   Learn↑, 10,   memory↑, 82,   Mood↑, 21,   motorD↑, 10,   neuroP↑, 108,   NP/CIPN↓, 1,   Obesity↓, 6,   OS↑, 3,   Pain↓, 2,   QoL↑, 2,   radioP↑, 2,   RenoP↓, 1,   RenoP↑, 3,   Risk↓, 1,   Sleep↑, 6,   Stress↓, 1,   Stroke↓, 4,   toxicity↓, 11,   toxicity↑, 1,   toxicity↝, 2,   toxicity∅, 1,   Weight↓, 1,   Wound Healing↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiFungal↑, 4,   AntiViral↑, 5,   Bacteria↓, 6,   Diar↓, 2,   GutMicro↑, 12,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↑, 2,   Ingr↝, 5,  
Total Targets: 411

Scientific Paper Hit Count for: BDNF, brain-derived neurotrophic factor
11 Exercise
10 Hydrogen Gas
10 Magnetic Fields
7 Lycopene
6 Curcumin
6 Sulforaphane (mainly Broccoli)
6 Mushroom Lion’s Mane, Hericium erinaceus
6 Silymarin (Milk Thistle) silibinin
6 Vitamin D3
5 Apigenin (mainly Parsley)
5 Luteolin
5 Zinc
4 Ellagic acid
4 Ginseng
4 Honokiol
4 Huperzine A/Huperzia serrata
4 isoorientin
4 L-Theanine
4 Resveratrol
3 Aromatherapy
3 Carnosic acid
3 Caffeine
3 Cysteamine
3 Ferulic acid
3 Ginkgolide B
3 Magnesium
3 Morin
3 Naringin
3 Piperine
3 Urolithin
2 flavonoids
2 Baicalin
2 Berberine
2 Bacopa monnieri
2 Boron
2 Boswellia (frankincense)
2 Centella asiatica / Gotu kola → asiaticoside
2 Choline
2 Folic Acid, Vit B9
2 Chrysin
2 Cichoric acid / Chicoric acid
2 Coenzyme Q10
2 Crocetin
2 Docosahexaenoic Acid
2 diet Short Term Fasting
2 Eugenol
2 Ginkgo biloba
2 Ginger/6-Shogaol/Gingerol
2 Hyperoside
2 Kaempferol
2 Mung Bean Sprouts
2 Lutein
2 Zeaxanthin
2 Magnolol
2 Melatonin
2 Moringa oleifera
2 Phenylbutyrate
2 Propolis -bee glue
2 Quercetin
2 Sesame seeds and Oil
2 Taurine
2 Thymoquinone
2 Ursolic acid
1 Annona atemoya Leaf Extract
1 isoquercitrin
1 Rutin
1 Anthocyanins
1 Alpha-Lipoic-Acid
1 Acetyl-l-carnitine
1 alpha Linolenic acid
1 Artemisinin
1 Astaxanthin
1 Baicalein
1 Beta-Caryophyllene
1 Betulinic acid
1 Caffeic acid
1 Capsaicin
1 Carvacrol
1 Carnosine
1 chitosan
1 Vitamin B12
1 Vitamin B2,Riboflavin
1 Echinacea
1 Cinnamon
1 Cynara scolymus/Globe Artichoke/Artichoke Extract
1 dietMediterranean
1 2-DeoxyGlucose
1 Calorie Restriction Mimetics
1 Diindolylmethane
1 Indole-3-carbinol
1 EGCG (Epigallocatechin Gallate)
1 Emodin
1 Phosphatidylserine
1 Fisetin
1 Formononetin
1 Flaxseed/Linseed
1 Gallic acid
1 Galantamine
1 Bifidobacterium animalis subsp. lactis GCL2505
1 Isoliquiritigenin
1 Isothiocyanates
1 Licochalcone A
1 Lecithin
1 SDG/lignans
1 Matrine
1 Magnetic Field Rotating
1 Lemon Balm/Melissa officinalis
1 Zeolite
1 Methylsulfonylmethane
1 nicotinamide adenine dinucleotide
1 Marjoram (Origanum majorana)
1 Protocatechuic acid
1 Polyphenols
1 probiotics
1 Pterostilbene
1 Salvia officinalis
1 Rosmarinic acid
1 Selenium
1 Shikonin
1 Spirulina(Arthrospira/Limnospira)
1 Selenite (Sodium)
1 Safflower yellow
1 Turmerones
1 Vitamin B6,pyridoxine
1 Vitamin E
1 Vitamin K2
1 Vitexin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1356  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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