AntiDiabetic Cancer Research Results

AntiDiabetic, AntiDiabetic: Click to Expand ⟱
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Type:
AntiDiabetic
Scientific Papers found: Click to Expand⟱
6281- DL,    Applications of Limonene in Neoplasms and Non-Neoplastic Diseases
- Review, Var, NA - Review, AD, NA - Review, Diabetic, NA
*antiOx↑, AntiTum↑, *AntiDiabetic↑, *neuroP↑, *GastroP↑, *ROS↓, *toxicity↓, *BioAv↑, ChemoSen↑, BAX↑, P53↓, Bcl-2↓, iNOS↓, COX2/PTGS2↓, eff↑, ROS↑, TumCCA↑, cycD1/CCND1↓, CycB/CCNB1↓, TumCMig↓, *lipid-P↓, *GSH↑, *SOD↑, *GPx↑, *hepatoP↑, *glucose↓, *AGEs↓, *Obesity↓, *Aβ↓, *AChE↓,
6348- DRE,    New prospects in oncotherapy: bioactive compounds from Taraxacum officinale
- Review, Var, NA
Ingr↝, TumCP↓, toxicity↓, *AntiDiabetic↑, *antiOx↑, *hepatoP↑, *diuretic↑, *Inflam↓, *neuroP↑, *Imm↑, eff↑, Apoptosis↑, tumCV↓, selectivity↑, TumCMig↓, EMT↓, MMP2↓, MMP9↓, Wnt↓, β-catenin/ZEB1↓, PI3K↓, Akt↓, JNK↓, ERK↓,
6365- DRE,    AN OVERVIEW OF THERAPEUTIC POTENTIALS OF TARAXACUM OFFICINALE (DANDELION): A TRADITIONALLY VALUABLE HERB WITH A REACH HISTORICAL BACKGROUND
- Review, Var, NA
*Inflam↓, *AntiTum↑, *Imm↑, *antiOx↑, *AntiDiabetic↑, *diuretic↑, *RenoP↑, *hepatoP↑, *neuroP↑, AntiTum↑, TNF-α↑, IL1β↑, Apoptosis↑, MMP2↓, MMP9↑, Synergy↑, Diff↑, *ROS↓, *HO-1↑, *NRF2↑, *lipid-P↓,
6362- DRE,    Taraxacum spp. in vitro and in vivo anticancer activity – A review
- Review, Var, NA
tumCV↓, *AntiDiabetic↑, *Imm↑,
6366- DRE,    A comprehensive review of the benefits of Taraxacum officinale on human health
- Review, Var, NA
*diuretic↑, *hepatoP↑, *Imm↑, *Bacteria↓, *AntiArt↑, *AntiDiabetic↑, *Obesity↓, *antiOx↓, *AntiCan↑, Dose?,
6819- EMD,    Recent advances in the therapeutic potential of emodin for human health
- Review, Nor, NA
AntiCan↑, *AntiDiabetic↑, *neuroP↑, *Inflam↓, *antiOx↑, *BioAv↓, *BioAv↑, *SOD↑, *GPx↑, *GSH↑, *NRF2↑, *ROS↓, *lipid-P↓, *Cyt‑c↓, *BAX↓, *Bcl-2↓, *iNOS↓, *NO↓, *IL6↓, *IL10↓, *IL17↓, *IFN-γ↓, *NF-kB↓, *LC3II↓, *Akt↓, *Beclin-1/ATG6↓, *AMPK↓, *TNF-α↓, *PGE2↓, *Apoptosis↓, *Casp3↓, *Casp9↓, *P53↓, *P21↓, *NAD↓, *ATP↓, *CHOP/DDIT3↓, *GADD34↓, *ATF4↓, tumCV↓, Apoptosis↑, TumCG↓, TumCI↓, TumMeta↓, CSCs↓, NOTCH1↓, STAT3↓, Synergy↑, miR-34a↓, *neuroP↑, *BDNF↓, *hepatoP↑, *ALAT↓, *AST↓, TG/TAG↓, ROS↑, Slug↓, EMT↓, Glycolysis↓, ChemoSen↑, P-gp/ABCB1↓, Ki-67↓, PCNA↓, ER Stress↑, TRIB3↑, NF-kB↑, TumMeta↑, *Imm↓, *toxicity↝,
6825- EMD,    Advances in the pharmacological effects and molecular mechanisms of emodin in the treatment of metabolic diseases
- Review, Nor, NA
*Inflam↓, *AntiTum↑, *Bacteria↓, *Imm↑, *glucose↓, *RenoP↑, *TLR4↓, *MyD88↓, *NLRP3↓, *NF-kB↓, *PI3K↓, *mTOR↓, *GSK‐3β↓, *Hif1a↓, *VEGF↓, *GutMicro↑, *Obesity↓, *AntiDiabetic↑, *AMPK↑, *PPARγ↑, *PPARγ↓, *toxicity↝, *hepatoP↑, *AST↓, *ALAT↓,
6836- EMD,    Emodin and the Anthraquinone Scaffold: Therapeutic Promise and Strategies to Overcome Translational Barriers
- Review, Nor, NA
*antiOx↑, *neuroP↑, *Inflam↓, *hepatoP↑, AntiTum↑, *Bacteria↓, *diuretic↑, *AntiDiabetic↑, *BioAv↝, *NF-kB↓, *AMPK↑, *JAK↓, *STAT3↓, *ROS↓, *lipid-P↓, ROS↑, TumCCA↑, CycB/CCNB1↓, BAX↑, Bcl-2↓, MOMP↑, Cyt‑c↑, Casp9↑, Casp3↑, Casp7↑, Apoptosis↑, P53↑,
6814- EMD,    Emodin: A Review of its Pharmacology, Toxicity and Pharmacokinetics
- Review, Nor, NA
AntiCan↑, *hepatoP↑, *Inflam↑, *antiOx↑, *AntiBio↑, *BioAv↓, *AntiViral↑, *AntiDiabetic↑, *neuroP↑, CSCs↓, NOTCH↓, β-catenin/ZEB1↓, STAT3↓, TumCCA↑, *TNF-α↓, IL6↓, IL1β↓, *MMP9↓, *HO-1↑, cMyc↓, Mcl-1↓, *antiAll↑,
6379- Eug,    Safety assessment of a standardized polyphenolic extract of clove buds: Subchronic toxicity and mutagenicity studies
- in-vivo, Nor, NA
*toxicity∅, *Dose↑, *Bacteria↓, *Inflam↓, *antiOx↑, *AntiDiabetic↑, *hepatoP↑, *AntiCan↑, *AntiThr↑,
6323- Eug,    Eugenol: An Insight Into the Anticancer Perspective and Pharmacological Aspects
- Review, Var, NA - Review, Arthritis, NA
*AntiCan↑, *AntiDiabetic↑, *cardioP↑, *toxicity↝, *GutMicro↑, *neuroP↑, *BioAv⇅, *BioAv↝, *antiOx↑, *Inflam↑, *AntiArt↑, *TNF-α↓, *IL6↓, *IL10↓, *GSH↑, *GPx↑, *Catalase↑, *MDA↓, *TAC↑, TumCMig↓, TumCI↓, Akt↑, FOXO3↑, Casp3↑, Casp9↑, P21↑, angioG↓, TumCI↓, Apoptosis↑, NF-kB↓, Synergy↑, Synergy↑, ChemoSen↑, NA↑, Casp3↑, Casp9↑, *AntiDiabetic↑, *glucose↓, *ROS↓, *Inflam↓, *MDA↓, *GSH↑, *BioAv↑,
6873- FA,    Ferulic acid: extraction, estimation, bioactivity and applications for human health and food
- Review, Nor, NA
*Inflam↓, *AntiBio↑, AntiCan↑, *AntiDiabetic↑, *cardioP↑, *neuroP↑, *ROS↓, *antiOx↑, *AGEs↓, *Catalase↑, *SOD↑,
6430- FEO,    Foeniculum vulgare: A comprehensive review of its traditional use, phytochemistry, pharmacology, and safety
- Review, Nor, NA
*Dose↝, *Bacteria↓, *hepatoP↑, *antiOx↑, *AntiThr↑, *AntiDiabetic↑, *toxicity↝,
6909- FIS,    Modulation of PI3K/ AKT/ mTOR and apoptosis pathway in colon cancer cells by the plant flavonoid fisetin
- in-vitro, Colon, Caco-2
AntiCan↑, tumCV↓, Bcl-2↓, PI3K↓, mTOR↓, NF-kB↓, BAX↑, *AntiDiabetic↑, *AntiCan↑, *Inflam↓, *antiOx↑, *neuroP↑,
6895- FIS,    Enhanced bioavailability and pharmacokinetics of a novel hybrid-hydrogel formulation of fisetin orally administered in healthy individuals: a randomised double-blinded comparative crossover study
- in-vivo, Nor, NA
*neuroP↑, *cardioP↑, *chemoPv↑, *AntiDiabetic↑, *Inflam↓, *ROS↓, *BioAv↓, *BioAv↑, *eff↑, *Half-Life↓,
6925- Flav,    Important Flavonoids and Their Role as a Therapeutic Agent
- Review, Nor, NA
AntiCan↑, *antiOx↑, *Inflam↓, *AntiViral↑, *neuroP↑, *cardioP↑, *AChE↓, *cognitive↑, Risk↓, *Stroke↓, *AntiDiabetic↑, *AntiFungal↑,
6924- Flav,    Plant Flavonoids: Chemical Characteristics and Biological Activity
- Review, Nor, NA
*ROS↓, *antiOx↑, *Inflam↓, *Bacteria↓, *cardioP↑, AntiCan↑, *AntiAge↑, *AntiDiabetic↑, AntiViral↑, *BioAv↓, *AntiFungal↑,
6981- Form,    Formononetin: a review of its source, pharmacology, drug combination, toxicity, derivatives, and drug delivery systems
- Review, Var, NA - Review, AD, NA - Review, PSA, NA
BioAv↝, *memory↑, *ROS↓, *AChE↓, *NF-kB↓, *Keap1↝, *NRF2↑, *Inflam↓, *PGC-1α↝, *HO-1↓, *p‑tau↓, *cognitive↑, *BDNF↑, *5HT↑, *Stroke↓, *PARP1↓, *AIF↓, *Casp3↓, NP/CIPN↓, *neuroP↑, *NGF↑, *TNF-α↓, *IL1β↓, *IL18↓, *IL6↓, *VCAM-1↓, *pol-M2 MC↑, *hepatoP↑, *AST↓, *ALAT↓, *LC3II↑, *Beclin-1/ATG6↑, *p62↑, *COX2/PTGS2↑, *MMP↑, *ATP↑, *GSH↑, *Catalase↑, *GPx↑, *MDA↓, *antiPs↑, *AntiDiabetic↑, *glucose↓, *Insulin↑, *GutMicro↑, *Obesity↓, COX2/PTGS2↓, cycD1/CCND1↓, TumCCA↑, EGFR↓, GSK‐3β↑, Mcl-1↓, *toxicity↓, TumCP↓, Hif1a↓, VEGF↓, ERK↓, LAMs↓, Cyt‑c↑, Casp9↑, Casp3↑, PARP↑, TumCD↑, mitA↑, BACH1↓, P53↓, ROS↑, PD-1↓, NF-kB↓, *Bacteria↓, *AntiViral↑, *mt-ROS?, *PI3K↓, *chemoP↑, ChemoSen↑, Synergy↑, *toxicity↓, *BioAv↑, *BioAv↑, *Synergy↑, *antiAll↑,
6988- Form,    Formononetin ameliorates high glucose‑induced endothelial dysfunction by inhibiting the JAK/STAT signaling pathway
- in-vitro, Nor, HUVECs
*JAK2↓, *Casp3↑, *Inflam↓, *IL1β↓, *ICAM-1↓, *AntiDiabetic↑,
8584- FS,    Anti-Oxidant and Anti-Cancer Properties of Flaxseed
- Review, Nor, NA
*Ingr↝, *cardioP↑, *LDL↓, *lipidLev↓, *AntiDiabetic↑, *hepatoP↑, *AntiCan↑, *Analgesic↑, *AntiArt↑, *CRP↓, *TNF-α↓, *Inflam↓, *toxicity↝, *neuroP↑, *Ingr↝, *Ingr↝, *AntiViral↑, Risk↓, *Ingr↝, *hs-CRP↓, *GutMicro↑, *TJ↑, *OCLN↝, *MLC2/MYL9↝, *VCAM-1↓, *Akt2↓, *IKKα↓, *NF-kB↓, Synergy↑, HER2/EBBR2↓, MAPK↓, PI3K↓, Akt↓, EGFR↓, TumCG↓, TumMeta↓, IGF-1↓, COX2/PTGS2↓, PGE2↓, CDK4↓, TNF-α↓, IL1β↓, lipid-P↑, P53↑, MDM2↑, cl‑Casp3↑, cl‑PARP↑, cl‑Casp7↑, BAX↑, Bcl-2↓, Bax:Bcl2↑, Cyt‑c↑, Casp9↑, Ki-67↓, CYP1A1↑, p38↑, ERK↑, Synergy↑, ChemoSen↑, *BioAv↑, eff↝, Ingr↝,
8585- FS,    Dietary flaxseed: Cardiometabolic benefits and its role in promoting healthy aging
- Review, Nor, NA
*cardioP↑, *Obesity↓, *lipidLev↓, *BP↓, *Inflam↓, *CRP↓, *IL6↓, *ROS↓, *hepatoP↑, *Ingr↝, *GutMicro↑, *Dose↑, *Ingr↝, *Ingr?, *CompStab↝, *MDA↓, *hs-CRP↓, *TNF-α↓, *AntiDiabetic↑, *ALAT↓, *AST↓, *GGT/CD224↓, *TG/TAG↓, *LDL↓, *HDL∅, *TC↓, *glucose↓, *Insulin↓, *SIRT1↑, *Dose↝, *Dose?,
8586- FS,    The Role of Flaxseed in Improving Human Health
- Review, Nor, NA
*lipidLev↓, *BP↓, *HOMA↓, *AntiCan↑, *antiOx↑, *BioAv↑, *Ingr↑, *Ingr↝, *Ingr↝, *GutMicro↑, *CompStab↝, *TC↓, *TG/TAG↓, *LDL↓, *HDL↑, *BP↓, *AntiDiabetic↑, *AntiCan↑, TumCD↑, selectivity↑, TumCP↓, Apoptosis↑, DNAdam↑, i-ROS↑, TumCCA↑, CDK2↓, CDK4↓, cycD1/CCND1↓, cycE/CCNE↓, ChemoSen↑, Synergy↑, *Inflam↓, *hs-CRP↓, *VCAM-1↓, *BDNF↑,
8589- FS,    Flaxseed Lignans as Important Dietary Polyphenols for Cancer Prevention and Treatment: Chemistry, Pharmacokinetics, and Molecular Targets
- Study, Var, NA
Risk↓, Ingr?, *antiOx?, *Inflam↓, *Estro↓, *Ingr↑, *neuroP↑, *Obesity↓, TumMeta↓, TumCP↓, *AntiAg↑, *AntiDiabetic↑, *ROS↓, *GutMicro↑, FOXM1↓, PCNA↓, Ki-67↓, CDK2↓, Akt↓, PDGF↓, ERK↓, p‑GSK‐3β↓, IGFR↓, p‑MDM2↓, EGFR↓, FASN↓, CYP3A4↓, COX2/PTGS2↓, Cyt‑c↑, cl‑PARP↑, Casp3↑, p‑P53↑, Bcl-2↓, VEGF↓, VEGFR2/KDR/Flk1↓, BRCA1↓, BRCA2↓, survivin↓, GADD45A↓, FAK↓, pax↓, Rho↓, Rac1↓, Cdc42↓, MMP2↓, TIMP1↑, TIMP2↑, angioG↓, MMP↓, ChemoSen↑,
7008- Fuc,    Ten Years of Research on Fucoidan and Cancer: Focus on Its Antiangiogenic and Antimetastatic Effects
- Review, Var, NA
antiOx↑, AntiViral↑, Imm↝, *AntiThr↑, *AntiDiabetic↑, AntiTum↑, TumMeta↑, angioG↓, Hif1a↓, VEGF↓, MMPs↓, EMT↓, N-cadherin↓, E-cadherin↑, TIMP1↑, PI3K↓, Akt↓, mTOR↓, MMP2↓, ChemoSen↑, OS↑, fatigue↓, CD31/PECAM-1↓,
7028- GA,    Gallic acid: Pharmacological activities and molecular mechanisms involved in inflammation-related diseases
- Review, Nor, NA
*toxicity↓, *Inflam↓, *NF-kB↓, AntiTum↑, Bacteria↓, *AntiDiabetic↑, *Obesity↓, *AntiBio↑, *Stroke↓, *NO↓, *PGE2↓, *IL6↓, *MAPK↓, *TNF-α↓, *IL1β↓, *MCP1/CCL2↓, *ICAM-1↓, *TIMP1↓,
7069- GABA,    United States Pharmacopeia (USP) Safety Review of Gamma-Aminobutyric Acid (GABA)
- Review, Nor, NA
*toxicity↓, *BP↓, *AntiDiabetic↑, *AntiCan↑, *antiOx↑, *Inflam↓, *AntiBio↑, *other↝, *cognitive↑, *GH↑, *Sleep↑, *BioAv↑, *Half-Life↝, *BBB↓, *Synergy↑,
7103- GEN,    A Comprehensive Review of Genistein's Effects in Preclinical Models of Cervical Cancer
- Review, Cerv, NA
TumCP↓, Apoptosis↑, RadioS↑, ChemoSen↑, *antiOx↑, *Inflam↓, *Bacteria↓, *AntiViral↑, *AntiDiabetic↑, *neuroP↑, AntiCan↑, TumCG↓, TumCI↓, TumCCA↑, cl‑PARP↑, selectivity↑, CycB/CCNB1↓, CDK1↓, p‑cDC2↓, p‑ERK↓, p‑p38↑, p‑JNK↑, MMP9↓, TIMP1↑, BioAv↓, BioAv↑, Half-Life↑,
7102- GEN,    Genistein: An Integrative Overview of Its Mode of Action, Pharmacological Properties, and Health Benefits
- Review, Var, NA
*antiOx↑, *Inflam↓, *Bacteria↓, *AntiViral↑, *Dose↝, *AntiDiabetic↑, angioG↑, Apoptosis↑, tumCV↓, MyD88↑, Beclin-1/ATG6↑, LC3II↑, TLR4↑, TumAuto↑, mTOR↓, p62↓, TumCCA↑, TumCP↓, Akt↑, P53↑, DNMT3B↓, MEK↓, hTERT/TERT↓, VEGF↓, NF-kB↓, IAP1↓, MDR1↓, p‑Akt↓, Synergy↑, ChemoSen↑,
6571- Ger,    Unlocking the therapeutic potential of Geraniol: an alternative perspective for metabolic disease management
- Review, Obesity, NA
*lipidLev↓, *antiOx↓, Inflam↓, *ROS↓, *BioAv↑, *AntiDiabetic↑, *Obesity↓,
7338- Gra,    Pharmacological Activities of Soursop (Annona muricata Lin.)
- Review, Var, NA
AntiCan↑, *AntiDiabetic↑, *Diar↓, *Bacteria↓, *AntiViral↑, *Wound Healing↑, MMP2↓, MMP9↓, MMP↓, ROS↑, TumCCA↑, BAX↑, Bcl-2↓, Casp3↑, *BAX↓, *MDA↓, *Catalase↑, *SOD↑, *GSH↑, *NO↑, *PGE2↑, *HSP70/HSPA5↑,
7490- H2,    Long-term administration of hydrogen-rich water enhances quality of life in diabetic rats and reduces renal neoplasm incidence through modulation of inflammatory and metabolic pathways
- in-vivo, Diabetic, NA
*BG↓, *AntiDiabetic↑, *BMD↑, *hepatoP↑, *RenoP↑, *QoL↑,
7359- HibSad,    Novel Insight into the Cellular and Molecular Signalling Pathways on Cancer Preventing Effects of Hibiscus sabdariffa: A Review - PubMed
- Review, Var, NA
AntiCan↑, TumCP↓, Apoptosis↑, TumCCA↑, P53↑, P21↑, p27/CDKN1B↑, BAD↑, BAX↑, Casp3↑, Casp7↑, Casp8↑, Casp9↑, *AntiBio↑, *Inflam↓, *antiOx↑, *BP↓, *AntiDiabetic↑, HDAC1↓, HDAC3↓, tumCV↓, LDL↓, DNAdam↑, MMP↓, *Catalase↑, *SOD↑, *GPx↑, *GSH↑, *antiOx↑, *ROS↓, TumCMig↓, TumCI↓, selectivity↑, RAS↓, Akt↓, NF-kB↓, MMP2↓, PI3K↓, Bcl-2↓, Bcl-xL↓, PCNA↓, cycA1/CCNA1↓, cycD1/CCND1↓, cycE/CCNE↓,
7358- HibSad,    Chemopreventive properties and molecular mechanisms of the bioactive compounds in Hibiscus sabdariffa Linne
- Review, Var, NA
chemoPv↑, *ROS↓, *other↝, *hepatoP↑, *lipid-P↓, Apoptosis↑, *LDL↓, RAS↓, Akt↓, NF-kB↓, Rho↝, MMPs↓, *AntiDiabetic↑, *Catalase↑, *GSH↑,
7372- HOO,    Ozone-modified properties of pumpkin seed oil as anti-H. pylori, anticancer, anti-diabetic and anti-obesity agent
- in-vitro, Pca, PC3
Apoptosis↑, AntiDiabetic↑, Obesity↑, TumCCA↑, other↝,
7630- Ins,    Modulation of both Insulin Resistance and Cancer Growth by Inositol
- Review, Var, NA - Review, Diabetic, NA
*IRes↓, *AntiDiabetic↑, *glucose↝, AntiCan↑, PI3K↓, Akt↓, Glycolysis↓, STK11/LKB1↑, *FASN↓, *LDL↓, *FFA/NEFA↓, *ROS↓, ROS↑, IGF-1↓,
7760- ISL,    Pharmacological Potentials and Delivery Strategies of Isoliquiritigenin: Challenges and Advances in Enhancing Bioavailability
- Review, Nor, NA
*BioAv↓, GlucoseCon↓, LDH↓, PDK1 / PDPK1↓, Glycolysis↓, mt-OXPHOS↓, Bax:Bcl2↓, cl‑Casp3↑, cl‑Casp9↑, Apoptosis↑, Hif1a↓, ROS↑, *AntiDiabetic↑, *cardioP↑, *RenoP↑, *ROS↓, *NF-kB↓, *NLRP3↓, *Pyro↓, *antiPs↑, *IL6↓, *IL8↓, CompStab↑, BioAv↑, BioAv↑,
7765- ISL,    Isoliquiritigenin as a modulator of the Nrf2 signaling pathway: potential therapeutic implications
- Review, Var, NA
*antiOx↑, *AntiCan↑, *AntiTum↑, *AntiDiabetic↑, *cardioP↑, *RenoP↑, *NRF2↑, *NQO1↝, *HO-1↑, *SOD↑, *toxicity↓, *BioAv↓, *Half-Life↓, *BBB↑, *neuroP↑, *Stroke↓, *GSK‐3β↓, *p‑GSK‐3β↑, *hepatoP↑, *Inflam↓, *ROS↓, *MPO↓, *MDA↓,
7778- ISL,    Isoliquiritigenin, a potent human monoamine oxidase inhibitor, modulates dopamine D1, D3, and vasopressin V1A receptors
- Study, Park, NA - Study, AD, NA
*neuroP?, TumCP↓, *Inflam↓, *hepatoP↑, angioG↓, *AntiBio↑, *AntiDiabetic↓, *ROS↓, *antiOx↑, *MAOA↓, *MAOB↓,
7814- ISQ,    Isoquercitrin Attenuates Steatohepatitis by Inhibition of the Activated NLRP3 Inflammasome through HSP90
- in-vivo, Nor, NA
*ROS↓, *AntiCan↑, *cardioP↑, *AntiDiabetic↑, *NLRP3↓, *HSP90↓, *AST↓, *ALAT↓, *antiAll↑,
7791- ISQ,    Isoquercitrin: pharmacology, toxicology, and metabolism
- Review, Nor, NA
*BioAv↑, *chemoP↑, *ROS↓, *cardioP↑, *AntiDiabetic↑, *Dose↝, *antiAll↑,
7848- ISQ,    Review of anticancer mechanisms of isoquercitin
- Review, Var, NA
BioAv↑, eff↑, *antiOx↓, TumCP↓, *Inflam↓, *AntiDiabetic↑, lipid-P↓, *toxicity↓, *Half-Life↝, *Half-Life↑, *XO↝, *IronCh↝, *VitC↑, *ROS↓, β-catenin/ZEB1↓, Casp3↑, Casp8↑, Casp9↑, MMP↓, p‑ERK↓, p‑cJun↑,
8039- IVM,    Ivermectin-Induced Apoptotic Cell Death in Human SH-SY5Y Cells Involves the Activation of Oxidative Stress and Mitochondrial Pathway and Akt/mTOR-Pathway-Mediated Autophagy
- in-vitro, neuroblastoma, SH-SY5Y
*toxicity↑, TumCD↑, ROS↑, mtDam↑, Apoptosis↑, MitoP↑, TumAuto↑, p‑Akt↓, p‑mTOR↓, LC3II↑, Beclin-1/ATG6↑, ATG5↑, PINK1↑, PARK2↑, tumCV↓, MDA↑, SOD↑, Catalase↑, eff↓, MMP↓, BAX↑, cl‑Casp3↑, cl‑Casp9↑, cl‑PARP↑, Cyt‑c↑, Bcl-2↓, proCasp3↓, Bax:Bcl2↑, eff↑, *AntiP↑, *Inflam↓, *AntiDiabetic↑, *AntiViral↑, BBB∅, toxicity↝,
7917- IVT,    A review on the pharmacological effects of vitexin and isovitexin
- Review, Nor, NA - Review, AD, NA
*antiOx↑, *AntiCan↑, *Inflam↓, *neuroP↑, *AChE↓, *BChE↓, *BACE/β-secretase↓, *Stroke↓, *AntiAg↓, *AntiDiabetic↑, *AGEs↓, *IL1β↓, *IL6↓, *IL8↓, *TNF-α↓, *Obesity↓, *BioAv↝, *BioAv↓,
7891- IVT,  VT,    Effects of C-glycosylation on anti-diabetic, anti-Alzheimer's disease and anti-inflammatory potential of apigenin
- Review, AD, NA
*AntiDiabetic↑, *Inflam↓, *AGEs↓, *AChE↓, *BChE↓, *PTP1B↓,
8095- KAE,    Kaempferol: A Key Emphasis to Its Anticancer Potential
- Review, Var, NA
*AntiBio↑, *Inflam↓, *AntiTum↓, *antiOx↑, *cardioP↑, *neuroP↑, *AntiDiabetic↑, Risk↓, TumCCA↑, EMT↓, PI3K↓, Akt↓, MMP2↓, Casp3↑, Casp7↑, Casp9↑, PARP↑, *ROS↓, angioG↓, *BioAv↑, BioAv↑, selectivity↑, GLUT1↓, MCT1↓, ROS↓, ROS↑, Trx↓, Cyt‑c↑, MMP↓, miR-21↓, SOCS-3↓, STAT3↓, CDK1↓, CycB/CCNB1↑, HIF-1↓, JAK1↑, PTEN↑,
8105- KAE,    Chemo-preventive and therapeutic effect of the dietary flavonoid kaempferol: A comprehensive review
- Review, Var, NA
Apoptosis↑, tumCV↓, TumCCA↑, PI3K↓, Akt↓, EMT↓, N-cadherin↓, E-cadherin↓, Slug?, Snail?, MMP2↓, MMP9↓, CTSB↓, CTSD↓, Casp3↑, Casp8↑, Casp9↑, TIMP2↓, Akt↓, TumCD↑, i-Ca+2↑, MMP↓, *ROS↓, *SOD↑, *Catalase↑, *GPx↑, *GSTs↑, *AST↓, *ALAT↓, *MDA↓, *CYP2E1↓, *NRF2↑, *AGEs↓, *IL6↓, *TNF-α↓, *NF-kB↓, *Casp3↓, *BAX↓, *antiAll↑, *COX2/PTGS2↓, *PGE2↓, *RUNX2↑, *BMP2↑, *COL1↑, *p62↑, *FASN↓, *DGAT1↓, FOXP3↑, DNAdam↑, ROS↑, Catalase↓, *ROS↓, *MMP↑, *Cyt‑c↓, *AntiDiabetic↑, *Obesity↓, *cardioP↑,
8058- KAE,    A randomized, placebo‐controlled trial evaluating the safety of excessive administration of kaempferol aglycone
- Trial, Nor, NA
*AntiBio↑, *antiOx↑, *Inflam↓, *AntiTum↑, *AntiDiabetic↑, *cardioP↑, *neuroP↑, *Dose↝, *toxicity↓,
8079- KAE,    Endoplasmic Reticulum Stress-Mediated Apoptosis Induced by Kaempferol in Colorectal Cancer Cells
- in-vitro, CRC, DLD1 - in-vitro, Lung, A549 - in-vitro, Liver, HUH7 - in-vitro, Cerv, HeLa
*antiOx↑, *AntiBio↑, *AntiDiabetic↑, *AntiCan↑, Dose↝, TumCP↓, ER Stress↑, Apoptosis↑, Bcl-2↓, BAX↑, Casp3↑, Casp9↑, Casp12↝, NF-kB↓, P53↑,
8056- KAE,    Kaempferol: advances in biosynthesis, molecular mechanisms, and therapeutic applications
- Review, Var, NA - Review, Diabetic, NA
*antiOx↑, *ROS↓, *NRF2↑, *Inflam↓, *NF-kB↓, *MAPK↓, *STAT↓, *AntiDiabetic↑, *AMPK↑, *IRes↑, Apoptosis↑, TumCCA↑, TumMeta↓, PI3K↓, Akt↓, Wnt↓, β-catenin/ZEB1↓, *AntiBio↑, *hepatoP↑, *SIRT1↝, *BioAv↓,
8278- LE,    Glycyrrhiza glabra (Licorice): A Comprehensive Review on Its Phytochemistry, Biological Activities, Clinical Evidence and Toxicology
- Review, Var, NA
*Ingr↝, *AntiCan↑, *AntiDiabetic↑, *AntiBio↑, *Inflam↓, *antiAll↑, *hepatoP↑, *cough?, *SoreThr?, *toxicity↝, *cardioP↑, *BioAv↝, *PGE2↓, *COX2/PTGS2↓, *AntiAg↑, *ROS↓, *NLRP3↓, *NF-kB↓, *AP-1↓, TumCCA↑, Apoptosis↑, TumMeta↑, *Dose↝, *Dose↝, Ingr↝, TumAuto↑, LC3II↑, PI3K↓, Akt↓, mTOR↓, *cognitive↑, *BloodF↑, ChemoSen↑, ROS↓, *chemoP↑, ROS↑, tumCV↓, MMP↓, *AntiBio↑, *toxicity↝,

Showing Research Papers: 51 to 100 of 135
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 135

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 6,   Catalase↓, 1,   Catalase↑, 1,   GSH↑, 1,   GSTs↑, 1,   H2O2↑, 1,   HO-1↑, 1,   lipid-P↓, 1,   lipid-P↑, 3,   MDA↑, 1,   NQO1↑, 1,   NRF2↑, 1,   ROS↓, 4,   ROS↑, 31,   ROS↝, 1,   i-ROS↑, 2,   SOD↓, 1,   SOD↑, 1,   Trx↓, 2,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compI↓, 1,   mitResp↓, 1,   mtDam↑, 3,   mt-OXPHOS↓, 1,   PINK1↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 2,   AMP↑, 1,   ATP↓, 4,   FASN↓, 1,   glucoNG↓, 1,   GlucoseCon↓, 1,   Glycolysis↓, 5,   GSK‐3β↓, 1,   GSK‐3β↑, 1,   p‑GSK‐3β↓, 2,   HK2↓, 1,   lactateProd↓, 1,   LDL↓, 1,   PDK1 / PDPK1↓, 1,  

Cell Death(tgid=5) ⓘ

AIF↑, 1,   APAF1↑, 1,   Apoptosis↓, 2,   Apoptosis↑, 39,   BAD↑, 1,   BAX↓, 1,   BAX↑, 15,   Bax:Bcl2↓, 1,   Bax:Bcl2↑, 6,   Bcl-2↓, 16,   Bcl-2↑, 1,   Bcl-xL↓, 2,   Casp↑, 2,   Casp1↑, 1,   Casp12↝, 1,   Casp3↑, 26,   cl‑Casp3↑, 3,   proCasp3↓, 1,   Casp7↑, 5,   cl‑Casp7↑, 1,   Casp8↑, 6,   Casp9↑, 16,   cl‑Casp9↑, 2,   Cyt‑c↑, 10,   DR5↑, 1,   Fas↑, 1,   IAP1↓, 2,   IAP2/BIRC3↓, 1,   iNOS↓, 1,   Mcl-1↓, 2,   MDM2↑, 1,   p‑MDM2↓, 1,   MOMP↑, 1,   p38↑, 1,   p‑p38↑, 1,   pS2/TFF1↓, 1,   PUMA↑, 1,   survivin↓, 2,   TRAIL⇅, 1,   TRAILR↑, 1,   TumCD↓, 1,   TumCD↑, 4,   XIAP↓, 2,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 24,   Akt↑, 2,   p‑Akt↓, 3,   EGFR↓, 4,   ERK↓, 12,   ERK↑, 1,   p‑ERK↓, 2,   HER2/EBBR2↓, 1,   IGF-1R↓, 1,   IGFR↓, 1,   JAK↓, 1,   JAK1↑, 1,   JNK↓, 2,   JNK↑, 1,   p‑JNK↑, 1,   LIMK1↓, 1,   MAPK↓, 5,   MEK↓, 2,   mTOR↓, 10,   p‑mTOR↓, 1,   P70S6K↓, 1,   PI3K↓, 23,   p‑PI3K↓, 1,   PKA↓, 1,   PKCδ↓, 1,   PTEN↑, 2,   RAS↓, 2,   Sp1/3/4↓, 1,   STAT↓, 1,   STAT3↓, 6,   STK11/LKB1↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

cJun↓, 1,   p‑cJun↑, 1,   cMyc↓, 4,   DNMT3B↓, 1,   FOXM1↓, 1,   FOXO3↑, 1,   HDAC1↓, 1,   HDAC2↓, 1,   HDAC3↓, 1,   miR-106b↓, 1,   miR-21↓, 1,   miR-34a↓, 2,   miR-34a↑, 1,   other↑, 1,   other↝, 2,   tumCV↓, 12,  

Protein Folding & ER Stress(tgid=8) ⓘ

ER Stress↑, 4,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 1,   Beclin-1/ATG6↑, 2,   CTSB↓, 1,   CTSD↓, 1,   LC3II↑, 3,   MitoP↑, 1,   p62↓, 1,   PARK2↑, 1,   TumAuto↓, 1,   TumAuto↑, 7,  

DNA Damage & Repair(tgid=10) ⓘ

BRCA1↓, 2,   BRCA2↓, 1,   DNAdam↑, 11,   hTERT/TERT↓, 1,   P53↓, 2,   P53↑, 9,   P53↝, 1,   p‑P53↑, 2,   PARP↑, 3,   cl‑PARP↑, 6,   PCNA↓, 4,   TOP1↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 4,   CDK2↓, 5,   CDK4↓, 6,   CDK6↓, 2,   cycA1/CCNA1↓, 1,   CycB/CCNB1↓, 4,   CycB/CCNB1↑, 1,   cycD1/CCND1↓, 10,   cycE/CCNE↓, 3,   GADD45A↓, 1,   Ki-67↓, 5,   mitA↑, 1,   P21↑, 5,   p27/CDKN1B↓, 1,   p27/CDKN1B↑, 1,   pRB↓, 1,   TumCCA?, 1,   TumCCA↑, 34,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

cFos↓, 1,   CSCs?, 1,   CSCs↓, 5,   Diff↑, 1,   IGF-1↓, 4,   Ki-67↓, 5,   mTORC1↓, 1,   NOTCH↓, 3,   NOTCH1↓, 1,   NOTCH1↑, 1,   Shh↓, 1,   TumCG↓, 8,   TumCP↓, 25,   Wnt↓, 4,  

Migration(tgid=13) ⓘ

AP-1↓, 2,   BACH1↓, 1,   Ca+2↑, 2,   i-Ca+2↑, 1,   Cdc42↓, 1,   Cofilin↓, 1,   p‑Cofilin↑, 1,   E-cadherin↓, 3,   E-cadherin↑, 3,   EMT↓, 9,   EMT↝, 1,   F-actin↓, 1,   FAK↓, 1,   p‑FAK↓, 1,   LAMs↓, 1,   LIMK2↓, 1,   MMP1↓, 1,   MMP2↓, 17,   MMP9↓, 14,   MMP9↑, 1,   MMPs↓, 5,   N-cadherin↓, 3,   pax↓, 1,   PDGF↓, 1,   Rac1↓, 1,   Rho↓, 1,   Rho↝, 1,   ROCK1↓, 1,   Slug?, 1,   Slug↓, 1,   Snail?, 1,   TET1↑, 1,   TGF-β↓, 1,   TIMP1↑, 5,   TIMP2↓, 1,   TIMP2↑, 2,   TRIB3↑, 1,   TumCI↓, 11,   TumCMig↓, 15,   TumMeta↓, 12,   TumMeta↑, 3,   β-catenin/ZEB1↓, 7,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 17,   angioG↑, 1,   CD31/PECAM-1↓, 2,   HIF-1↓, 2,   Hif1a↓, 7,   VEGF↓, 10,   VEGFR2/KDR/Flk1↓, 2,  

Barriers & Transport(tgid=15) ⓘ

BBB∅, 1,   EPR↑, 1,   GLUT1↓, 1,   MMP↓, 17,   TRPM7↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

p‑cDC2↓, 1,   COX2/PTGS2↓, 6,   COX2/PTGS2↑, 1,   CXCR4↓, 2,   FOXP3↑, 1,   HMGB1↓, 1,   IL10↓, 1,   IL10↑, 1,   IL17↓, 1,   IL1β↓, 2,   IL1β↑, 1,   IL6↓, 4,   IL8↓, 1,   Imm↑, 5,   Imm↝, 1,   Inflam↓, 9,   Inflam↝, 1,   MCT1↓, 1,   MyD88↑, 1,   NF-kB↓, 16,   NF-kB↑, 1,   NK cell↑, 2,   p65↓, 1,   PD-1↓, 1,   PD-L1↓, 1,   PGE2↓, 1,   PSA↓, 1,   RANTES↓, 1,   SOCS-3↓, 1,   TLR4↑, 1,   TNF-α↓, 3,   TNF-α↑, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 1,   ERα/ESR1↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 7,   BioAv↑, 8,   BioAv↝, 4,   CBR1↓, 1,   ChemoSen↑, 30,   CompStab↓, 1,   CompStab↑, 1,   CYP1A1↑, 1,   CYP3A4↓, 1,   DDS↑, 1,   Dose?, 1,   Dose↝, 8,   eff↓, 2,   eff↑, 16,   eff↝, 1,   GSTM1↑, 1,   Half-Life↓, 1,   Half-Life↑, 1,   MDR1↓, 1,   P-gp/ABCB1↓, 3,   P-gp/ABCB1⇅, 1,   RadioS↑, 6,   selectivity↑, 12,   Synergy↑, 17,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 2,   AR↓, 1,   AST↓, 1,   BRCA1↓, 2,   CIT↓, 1,   EGFR↓, 4,   ERα/ESR1↓, 1,   FOXM1↓, 1,   HER2/EBBR2↓, 1,   hTERT/TERT↓, 1,   IL6↓, 4,   LDH↓, 1,   PD-L1↓, 1,   PSA↓, 1,   TG/TAG↓, 1,   TRIB3↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 28,   AntiDiabetic↑, 5,   AntiTum↑, 11,   cardioP↑, 4,   chemoP↑, 8,   chemoPv↑, 7,   ChemoSideEff↓, 1,   fatigue↓, 1,   hepatoP↑, 4,   neuroP↑, 2,   NP/CIPN↓, 2,   Obesity↑, 1,   OS↑, 2,   Pain↓, 1,   QoL↑, 1,   radioP↑, 3,   RenoP↑, 1,   Risk↓, 11,   Risk↑, 1,   toxicity↓, 4,   toxicity↝, 1,   TumVol↓, 1,   TumW↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiViral↑, 3,   Bacteria↓, 1,   GutMicro↑, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Api↑, 1,   Ingr?, 1,   Ingr↝, 6,  
Total Targets: 342

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx?, 1,   antiOx↓, 4,   antiOx↑, 76,   Catalase↑, 22,   Fenton↓, 1,   GPx↑, 18,   GPx4↑, 1,   GSH↓, 1,   GSH↑, 24,   GSR↑, 2,   GSTs↑, 5,   H2O2↓, 1,   HDL↓, 1,   HDL↑, 7,   HDL∅, 1,   HO-1↓, 1,   HO-1↑, 11,   hyperG↝, 1,   Keap1↝, 1,   lipid-P↓, 18,   MDA↓, 22,   MDA↑, 1,   MPO↓, 4,   NADH↓, 1,   NQO1↑, 2,   NQO1↝, 1,   NRF2↑, 17,   RNS↓, 2,   ROS?, 1,   ROS↓, 63,   ROS↑, 1,   mt-ROS?, 1,   selenoP↑, 1,   SOD↑, 30,   SOD1↑, 2,   SOD2↑, 1,   TAC↑, 3,   Trx↑, 1,   TrxR1↑, 1,   uricA↓, 1,   VitC↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 2,   IronCh↝, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

DRP1/DNM1L↓, 1,   Insulin↓, 2,   Insulin↑, 3,   MFN2↑, 1,   mtDam↓, 1,   OCR↑, 1,   PGC-1α↝, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 3,   5LO↝, 1,   ALAT↓, 11,   AMPK↓, 1,   AMPK↑, 8,   ATP↓, 1,   ATP↑, 3,   CRM↑, 2,   DGAT1↓, 1,   FASN↓, 2,   FFA/NEFA↓, 2,   glucose↓, 15,   glucose↝, 1,   GlucoseCon↑, 1,   glyC↓, 1,   GSK‐3β↓, 6,   GSK‐3β↑, 1,   p‑GSK‐3β↑, 1,   HMG-CoA↓, 2,   LDL↓, 17,   lipidLev↓, 4,   NAD↓, 1,   PFK↓, 1,   PLA2↓, 2,   SIRT1↑, 1,   SIRT1↝, 1,   SREBP1/SREBF1↓, 1,  

Cell Death(tgid=5) ⓘ

AIF↓, 1,   Apoptosis↓, 1,   BAX↓, 5,   Bcl-2↓, 1,   Bcl-2↑, 1,   Casp↓, 1,   Casp12↓, 1,   Casp3↓, 5,   Casp3↑, 1,   cl‑Casp3↓, 1,   cl‑Casp8↓, 1,   Casp9↓, 1,   Cyt‑c↓, 2,   Fas↓, 1,   Ferroptosis↓, 1,   iNOS↓, 3,   necrosis↓, 1,   Pyro↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 2,   Akt↑, 4,   Akt2↓, 1,   CREB↑, 1,   ERK↓, 1,   IKKα↓, 1,   IκB↓, 1,   JAK↓, 1,   JAK2↓, 1,   JNK↓, 1,   MAPK↓, 4,   mTOR↓, 1,   mTOR↑, 1,   PI3K↓, 2,   PI3K↑, 4,   PP2A↑, 1,   PROKR1↑, 1,   PROKR2↑, 1,   PTP1B↓, 1,   RIP1↓, 1,   STAT↓, 1,   STAT3↓, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 6,   ATF2↑, 1,   ATF4↓, 2,   FOXO3↑, 1,   other?, 1,   other↓, 3,   other↑, 5,   other↝, 9,   RUNX2↑, 1,   SOX2↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↓, 1,   CHOP/DDIT3↓, 4,   ER Stress↓, 1,   GRP78/BiP↓, 2,   HSP70/HSPA5↓, 1,   HSP70/HSPA5↑, 2,   HSP90↓, 1,   NQO2↑, 1,   PERK↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 2,   Beclin-1/ATG6↑, 1,   LC3II↓, 1,   LC3II↑, 1,   MitoP↑, 1,   p62↑, 2,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 5,   P53↓, 1,   PARP1↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

GADD34↓, 1,   Ki-67↑, 1,   P21↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMP2↑, 1,   GH↑, 1,   HH↓, 1,   Ki-67↑, 1,   Nestin↑, 1,   neuroG↑, 1,   NOTCH1↑, 1,  

Migration(tgid=13) ⓘ

AntiAg↓, 1,   AntiAg↑, 10,   AP-1↓, 1,   Ca+2↓, 1,   COL1↑, 1,   MLC2/MYL9↝, 1,   MMP9↓, 3,   PROK2↑, 1,   TGF-β↓, 1,   TIMP1↓, 1,   Tyro3↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

Endoglin↑, 1,   p‑eNOS↑, 1,   Hif1a↓, 2,   NO↓, 5,   NO↑, 1,   TXA2↓, 1,   VCAM-1↓, 3,   VEGF↓, 3,   VEGF↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 1,   BBB↑, 2,   GastroP↑, 5,   GLUT4↑, 1,   H+/K+-ATPase↓, 1,   MMP↑, 3,   OCLN↓, 1,   OCLN↝, 1,   TJ↑, 1,   TRPC1↓, 1,   TRPM7↓, 1,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX1↓, 3,   COX2/PTGS2↓, 12,   COX2/PTGS2↑, 1,   ICAM-1↓, 2,   IFN-γ↓, 3,   IL10↓, 5,   IL10↑, 2,   IL12↓, 1,   IL17↓, 2,   IL18↓, 1,   IL1β↓, 9,   IL23↓, 1,   IL4↓, 1,   IL5↓, 1,   IL6↓, 19,   IL8↓, 3,   Imm↓, 1,   Imm↑, 23,   Imm↝, 1,   Inflam↓, 85,   Inflam↑, 2,   pol-M2 MC↑, 1,   MCP1/CCL2↓, 2,   MyD88↓, 1,   NF-kB↓, 23,   NLRP3↓, 5,   PGE2↓, 7,   PGE2↑, 1,   TLR4↓, 4,   TNF-α↓, 22,  

Cellular Microenvironment(tgid=17) ⓘ

GGT/CD224↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 1,   AChE↓, 14,   BChE↓, 6,   BDNF↓, 1,   BDNF↑, 5,   GABA↑, 1,   MAOA↓, 2,   MAOB↓, 2,   NGF↑, 3,   PSD95↑, 1,   TrkB↑, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 9,   Aβ↓, 7,   BACE/β-secretase↓, 3,   tau↓, 3,   p‑tau↓, 1,   XO↝, 1,   β-Amyloid↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 1,   ACE2↓, 1,   CYP19↓, 1,   END↑, 1,   Estro↓, 1,   PPARα↝, 1,   PPARγ↓, 1,   PPARγ↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 20,   BioAv↑, 26,   BioAv⇅, 2,   BioAv↝, 13,   CompStab↓, 1,   CompStab↝, 2,   CYP2E1↓, 2,   Dose?, 2,   Dose↑, 3,   Dose↝, 14,   eff↓, 1,   eff↑, 9,   eff↝, 1,   GSTA1↑, 1,   Half-Life↓, 2,   Half-Life↑, 1,   Half-Life↝, 4,   P450↓, 1,   Synergy↑, 4,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 11,   ALP↓, 2,   AST↓, 12,   BG↓, 1,   BloodF↑, 1,   BMD↑, 1,   BP↓, 14,   BUN↓, 1,   creat↓, 1,   CRP↓, 6,   HOMA↓, 1,   hs-CRP↓, 3,   IL6↓, 19,   IRes↓, 1,   IRes↑, 1,   IRes↝, 1,   LDH↓, 4,   LDH↑, 1,   NOS2↓, 1,   TC↓, 2,   TG/TAG↓, 4,   Urea↓, 1,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 2,   AntiAge↑, 6,   antiAll↑, 11,   AntiArt↑, 9,   AntiCan↑, 32,   antiCG↑, 1,   AntiDiabetic↓, 4,   AntiDiabetic↑, 128,   antiM↑, 1,   antiNeop↑, 1,   antiPs↑, 2,   antiPy↑, 1,   AntiTum↓, 1,   AntiTum↑, 6,   Bone Healing↑, 1,   cardioP↑, 52,   chemoP↑, 5,   chemoPv↑, 5,   cognitive↑, 15,   cough?, 1,   diuretic↑, 4,   fatigue↓, 2,   hepatoP↑, 47,   Learn↑, 1,   memory↑, 14,   motorD↑, 1,   Mucositis↓, 1,   neuroP?, 2,   neuroP↓, 1,   neuroP↑, 59,   Obesity↓, 27,   OS↑, 2,   Pain↓, 2,   QoL↑, 2,   radioP↑, 1,   RenoP↑, 11,   Sleep↑, 2,   SoreThr?, 1,   Strength↑, 1,   Stroke↓, 9,   toxicity?, 1,   toxicity↓, 18,   toxicity↑, 1,   toxicity⇅, 1,   toxicity↝, 8,   toxicity∅, 2,   Weight↓, 2,   Wound Healing↑, 14,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 18,   AntiFungal↓, 1,   AntiFungal↑, 11,   AntiP↑, 2,   AntiViral↑, 14,   Bacteria↓, 39,   Bacteria↑, 1,   Diar↓, 1,   GutMicro↑, 24,   Sepsis↓, 2,  

Ingredients & Constituents(tgid=25) ⓘ

CA↑, 1,   Catechins↑, 1,   FA↑, 1,   GA↑, 1,   Ingr?, 2,   Ingr↑, 4,   Ingr↝, 18,   Phen↑, 1,   QC↑, 1,  
Total Targets: 352

Scientific Paper Hit Count for: AntiDiabetic, AntiDiabetic
8 Chlorogenic acid
5 Kaempferol
4 Dandelion Root
4 Emodin
4 Flaxseed/Linseed
3 Astaxanthin
3 Carvacrol
3 Centella asiatica / Gotu kola → asiaticoside
3 Cinnamon
3 diet Fermented Foods
3 Isoliquiritigenin
3 isoquercitrin
3 Isovitexin
3 SDG/lignans
3 Metformin
2 Silver-NanoParticles
2 Allicin (mainly Garlic)
2 Biochanin A
2 Rutin
2 Carica papaya leaf extract
2 D-limonene
2 Eugenol
2 Fisetin
2 flavonoids
2 Formononetin
2 Genistein (soy isoflavone)
2 Hibiscus sabdariffa
2 Vitexin
2 Lemongrass Extract/Citral
2 Moringa oleifera
2 Mucuna pruriens/Velvet Bean
2 Nimbolide
2 Purple Corn / Purple Maize
2 Quercetin
2 Selenium NanoParticles
2 Ursolic acid
1 Astragalus
1 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
1 Anethole/trans-Anethole
1 Aloe anthraquinones
1 Bacopa monnieri
1 Boswellia (frankincense)
1 Black Rice, Oryza sativa
1 buckwheat sprouts
1 Capsaicin
1 Caffeic Acid Phenethyl Ester (CAPE)
1 Celastrol
1 Chocolate
1 Chrysin
1 Hydroxycinnamic-acid
1 Crocetin
1 Carvone
1 Cucurbitacin
1 Date Fruit Extract
1 diet Short Term Fasting
1 Ferulic acid
1 Fennel Oil/Foeniculum vulgare
1 Fucoidan
1 Gallic acid
1 Gamma-aminobutyric acid
1 Geraniol
1 Graviola
1 Hydrogen Gas
1 High-Ozonide Oil
1 Inositol
1 Ivermectin
1 Licorice
1 Luteolin
1 Lycopene
1 Magnolol
1 Matrine
1 Moringin
1 Mushroom Chaga, Inonotus obliquus
1 Mushroom Lion’s Mane, Hericium erinaceus
1 Neem
1 Marjoram (Origanum majorana)
1 Psoralidin
1 Curcumin
1 Thymol-Thymus vulgaris
1 Walnut
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1385  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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