HDAC Cancer Research Results

HDAC, Histone deacetylases: Click to Expand ⟱
Source:
Type:
Enzymes involved in regulating gene expression by removing acetyl groups from histones, the proteins around which DNA is wrapped.
-Many cancers exhibit altered expression levels of HDACs, which can contribute to the dysregulation of genes involved in cell growth, survival, and differentiation.
-HDACs can repress the expression of tumor suppressor genes, leading to uncontrolled cell proliferation and survival. This repression can be a key factor in the development and progression of cancer.
-HDAC inhibitors (HDACi) have been developed and are being investigated for their ability to reactivate silenced genes, induce cell cycle arrest, and promote apoptosis in cancer cells.
-HDAC1, HDAC2): Often overexpressed in various cancers, including breast, prostate, and colorectal cancers. Their overexpression is associated with poor prognosis.
-HDAC4, HDAC5): These may have both oncogenic and tumor-suppressive roles depending on the context and cancer type.
-While HDACs are not classified as traditional oncogenes, their overexpression and activity can contribute to oncogenic processes.
-HDAC inhibitor works by preventing the removal of acetyl groups from histones, thereby modulating gene expression, influencing cell behavior, and potentially reversing aberrant gene silencing seen in various diseases.
-HDAC inhibitors can help reactivate these genes, thereby inhibiting growth and inducing apoptosis in cancer cells.
Scientific Papers found: Click to Expand⟱
3234- EGCG,  Rad,    EGCG, a tea polyphenol, as a potential mitigator of hematopoietic radiation injury in mice
- in-vivo, Nor, NA
*DNMTs↓, *radioP↑, *HDAC↑,
3235- EGCG,    (-)-Epigallocatechin-3-gallate reverses the expression of various tumor-suppressor genes by inhibiting DNA methyltransferases and histone deacetylases in human cervical cancer cells
- in-vivo, Cerv, HeLa
DNMTs↓, HDAC↓,
3236- EGCG,  Buty,    Molecular mechanisms for inhibition of colon cancer cells by combined epigenetic-modulating epigallocatechin gallate and sodium butyrate
- in-vitro, Colon, RKO - in-vitro, Colon, HCT116 - in-vitro, Colon, HT29
Apoptosis↑, TumCCA?, HDAC1↓, DNMT1↓, survivin↓, HDAC↓, P21↑, NF-kB↑, γH2AX↑, ac‑H3↑, DNAdam↑,
3237- EGCG,    (-)-Epigallocatechin-3-gallate attenuates cognitive deterioration in Alzheimer's disease model mice by upregulating neprilysin expression
- in-vivo, AD, NA
*HDAC↓, *Aβ↓, cognitive↑,
3238- EGCG,    Green tea catechin, epigallocatechin-3-gallate (EGCG): mechanisms, perspectives and clinical applications
- Review, Var, NA
Telomerase↓, DNMTs↓, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, CDK6↓, HATs↓, HDAC↓, selectivity↑, uPA↓, NF-kB↓, TNF-α↓, *ROS↓, *antiOx↑, Hif1a↓, VEGF↓, MMP2↓, MMP9↓, FAK↓, TIMP2↑, Mcl-1↓, survivin↓, XIAP↓, PCNA↓, p16↑, P21↑, p27/CDKN1B↑, pRB↑, P53↑, MDM2↑, ROS↑, Casp3↑, Casp8↑, Casp9↑, Cyt‑c↑, Diablo↑, BAX⇅, cl‑PPARα↓, PDGF↓, EGFR↓, FOXO↑, AP-1↓, JNK↓, COX2/PTGS2↓, angioG↓,
3201- EGCG,    Epigallocatechin Gallate (EGCG): Pharmacological Properties, Biological Activities and Therapeutic Potential
- Review, Var, NA
*AntiCan↑, *cardioP↑, *neuroP↑, *BioAv↝, *BioAv↓, *BioAv↓, *Dose↝, *Half-Life↝, *BioAv↑, *BBB↑, *hepatoP↓, *other↓, *Inflam↓, *NF-kB↓, *AP-1↓, *iNOS↓, *COX2/PTGS2↓, *ROS↓, *RNS↓, *IL8↓, *JAK↓, *PDGFR-BB↓, *IGF-1R↓, *MMP2↓, *P53↓, *NRF2↑, *TNF-α↓, *IL6↓, *E2Fs↑, *SOD1↑, *SOD2↑, Casp3↑, Cyt‑c↑, PARP↑, DNMTs↓, Telomerase↓, Hif1a↓, MMPs↓, BAX↑, Bak↑, Bcl-2↓, Bcl-xL↓, P53↑, PTEN↑, TumCP↓, MAPK↓, HGF/c-Met↓, TIMP1↑, HDAC↓, MMP9↓, uPA↓, GlutMet↓, ChemoSen↑, chemoP↑,
672- EGCG,    Molecular Targets of Epigallocatechin—Gallate (EGCG): A Special Focus on Signal Transduction and Cancer
- Review, Var, NA
DNMT1↓, HDAC↓, G9a↓, PRC2↓, DNMT3A↓, 67LR↓, Apoptosis↑, TumCCA↑,
5227- EMD,    Emodin and emodin-rich rhubarb inhibits histone deacetylase (HDAC) activity and cardiac myocyte hypertrophy
- vitro+vivo, Nor, NA
*cardioP↑, HDAC↓, HDAC1↓, HDAC2↓, ac‑H3↑, Dose↝, BioAv↓,
6820- EMD,    The Health Benefits of Emodin, a Natural Anthraquinone Derived from Rhubarb—A Summary Update
- Review, Nor, NA - Review, Arthritis, NA - Review, AD, NA
*diuretic↑, *Bacteria↓, *Inflam↓, AntiCan↑, TumCP↓, TumCI↓, angioG↓, *toxicity↓, IFN-γ↑, IL12↑, ROS↑, TNF-α↓, TNF-α↓, TGF-β↓, MAPK↓, PKCδ↓, NF-kB↓, HER2/EBBR2↓, VEGF↓, DNAdam↑, Necroptosis↑, Glycolysis↓, GLUT1↓, PI3K↓, Akt↓, Casp9↑, Casp3↑, BAX↑, Bcl-2↓, Synergy↑, MMP2↓, MMP9↓, Synergy↑, ChemoSen↑, P-gp/ABCB1↓, SREBP2↓, Synergy↑, *other↝, *COX2/PTGS2↓, *Hif1a↓, *HDAC↓, *tau↓, *PKCδ↑, *ROS↓, *Inflam↓, AntiAg?, *antiAll↑,
6982- Form,    Formononetin: A Review of Its Anticancer Potentials and Mechanisms
- Review, Var, NA
AntiTum↑, Apoptosis↑, BAX↑, Bcl-2↓, Casp3↑, TumCCA↑, cycA1/CCNA1↓, CycB/CCNB1↓, cycD1/CCND1↓, TumCP↓, VEGF↓, FGF↓, MMP2↓, MMP9↓, Synergy↑, ChemoSen↑, chemoPv↑, p‑Akt↓, p‑STAT3↑, TumCMig↓, TumCI↓, TIMP1↑, TIMP2↑, PI3K↓, Akt↓, Dose↝, TumCG↓, TumW↓, TumVol↓, angioG↓, Casp3↑, Casp9↑, cl‑PARP↑, DNArepair↓, MMP↓, BAX↑, Bcl-2↓, DR5↑, ROS↑, eff↓, p‑ERK↓, PTEN↑, Hif1a↓, eff↑, Synergy↑, ChemoSen↑, HDAC↓, *BioAv↑, *Half-Life↝, *BioAv↝, *BioAv↑, *BioAv↑, *eff↑,
7067- GamB,    Gambogic Acid and Its Role in Chronic Diseases
- Review, Var, NA
*NF-kB↓, PI3K↓, Akt↓, STAT3↓, STAT5↓, IL6↓, COX2/PTGS2↓, iNOS↓, MMPs↓, Src↓, PKA↓, CXCR4↑, VEGF↓, Bcl-2↓, Bcl-xL↓, IAP1↓, Mcl-1↓, survivin↓, cycD1/CCND1↓, HSP90↓, HSP70/HSPA5↓, MAPK↓, HATs↓, HDAC↓, FAK↓, ROS↑, MMP7↓, MMP9↓, α-tubulin↑, cl‑PARP↑, TNF-α↓, BID↑, BAD↑, Cyt‑c↑, Casp3↑, Casp9↑, *AntiArt↑, *antiPs↑,
1435- GEN,  SFN,    The Effects of Combinatorial Genistein and Sulforaphane in Breast Tumor Inhibition: Role in Epigenetic Regulation
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF7
DNMTs↓, HDAC↓, Synergy↑, TumCCA↑, HMTs↓, HDAC2↓, HDAC3↓, KLF4↓, hTERT/TERT↓,
2875- HNK,    Inhibition of class I histone deacetylases in non-small cell lung cancer by honokiol leads to suppression of cancer cell growth and induction of cell death in vitro and in vivo
- in-vitro, Lung, A549 - in-vitro, Lung, H1299 - in-vitro, Lung, H460 - in-vitro, SCC, H226
HDAC↓, tumCV↓, TumCCA↑, cycD1/CCND1↓, ac‑H3↑, ac‑H4↑, selectivity↑, CDK2↓, CDK4↓,
2868- HNK,    Honokiol: A review of its pharmacological potential and therapeutic insights
- Review, Var, NA - Review, Sepsis, NA
*P-gp/ABCB1↓, *ROS↓, *TNF-α↓, *IL10↓, *IL6↓, eIF2α↑, CHOP/DDIT3↑, GRP78/BiP↑, BAX↑, cl‑Casp9↑, p‑PERK↑, ER Stress↑, Apoptosis↑, MMPs↓, cFLIP↓, CXCR4↓, Twist↓, HDAC↓, BMPs↑, p‑STAT3↓, mTOR↓, EGFR↓, NF-kB↓, Shh↓, VEGF↓, tumCV↓, TumCMig↓, TumCI↓, ERK↓, Akt↓, Bcl-2↓, Nestin↓, CD133↓, p‑cMET↑, RAS↑, chemoP↑, *NRF2↑, *NADPH↓, *p‑Rac1↓, *ROS↓, *IKKα↑, *NF-kB↓, *COX2/PTGS2↓, *PGE2↓, *Casp3↓, *hepatoP↑, *antiOx↑, *GSH↑, *Catalase↑, *RenoP↑, *ALP↓, *AST↓, *ALAT↓, *neuroP↑, *cardioP↑, *HO-1↑, *Inflam↓,
2864- HNK,    Honokiol: A Review of Its Anticancer Potential and Mechanisms
- Review, Var, NA
TumCCA↑, CDK2↓, EMT↓, MMPs↓, AMPK↑, TumCI↓, TumCMig↓, TumMeta↓, VEGFR2/KDR/Flk1↓, *antiOx↑, *Inflam↓, *BBB↑, *neuroP↑, *ROS↓, Dose↝, selectivity↑, Casp3↑, Casp9↑, NOTCH1↓, cycD1/CCND1↓, cMyc↓, P21?, DR5↑, cl‑PARP↑, P53↑, Mcl-1↑, p65↓, NF-kB↓, ROS↑, JNK↑, NRF2↑, cJun↑, EF-1α↓, MAPK↓, PI3K↓, mTORC1↓, CSCs↓, OCT4↓, Nanog↓, SOX4↓, STAT3↓, CDK4↓, p‑RB1↓, PGE2↓, COX2/PTGS2↓, β-catenin/ZEB1↑, IKKα↓, HDAC↓, HATs↑, H3↑, H4↑, LC3II↑, c-Raf↓, SIRT3↑, Hif1a↓, ER Stress↑, GRP78/BiP↑, cl‑CHOP/DDIT3↑, MMP↓, PCNA↓, Zeb1↓, NOTCH3↓, CD133↓, Nestin↓, ATG5↑, ATG7↑, survivin↓, ChemoSen↑, SOX2↓, OS↑, P-gp/ABCB1↓, Half-Life↓, Half-Life↝, Synergy↑, BioAv↓,
7655- IP,  SFN,    Combined Phytochemical Sulforaphane and Dietary Fiber Inulin Contribute to the Prevention of ER-Negative Breast Cancer via PI3K/AKT/MTOR Pathway and Modulating Gut Microbial Composition
- in-vivo, BC, NA
Dose↝, TumCG↓, TumW↓, GutMicro↑, HDAC↓, DNMTs↓, Akt↓, PI3K↓, mTOR↓, NF-kB↓, TumCCA↑, cl‑Casp3↑, cl‑Casp7↑, CDK2↓, CDK4↓, Risk↓, Dose↝,
7660- IP,    Overview of experimental data on reduction of colorectal cancer risk by inulin-type fructans
- Review, CRC, NA
SCFAs↑, Buty↑, PA↑, TumCG↓, HDAC↓, Apoptosis↑, TumMeta↓,
8065- KAE,    Kaempferol, a new nutrition-derived pan-inhibitor of human histone deacetylases
- in-vitro, Liver, HepG2 - in-vitro, CRC, HCT116
HDAC↓, tumCV↓, TumCP↓, selectivity↑, ac‑H3↝,
1064- LT,  Cisplatin,    Inhibition of cell survival, invasion, tumor growth and histone deacetylase activity by the dietary flavonoid luteolin in human epithelioid cancer cells
- vitro+vivo, Lung, LNM35 - in-vitro, CRC, HT-29 - in-vitro, Liver, HepG2 - in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231
Casp3↑, Casp7↑, HDAC↓,
2927- LT,    Luteolin Causes 5′CpG Demethylation of the Promoters of TSGs and Modulates the Aberrant Histone Modifications, Restoring the Expression of TSGs in Human Cancer Cells
- in-vitro, Cerv, HeLa
TumCMig↓, DNMTs↓, HDAC↓, HATs↓, ac‑H3↓, ac‑H4↓, MMP2↓, MMP9↓, HO-1↓, E-cadherin↑, EZH2↓, HER2/EBBR2↓, IL18↓, IL8↓, IL2↓,
2915- LT,    Luteolin promotes apoptotic cell death via upregulation of Nrf2 expression by DNA demethylase and the interaction of Nrf2 with p53 in human colon cancer cells
- in-vitro, Colon, HT29 - in-vitro, CRC, SNU-407 - in-vitro, Nor, FHC
DNMTs↓, TET1↑, NRF2↑, HDAC↓, tumCV↓, BAX↑, Casp9↑, Casp3↑, Bcl-2↓, ROS↓, GSS↑, Catalase↑, HO-1↑, DNMT1↓, DNMT3A↓, TET1↑, TET3↑, TET2↓, P53↑, P21↑,
2919- LT,    Luteolin as a potential therapeutic candidate for lung cancer: Emerging preclinical evidence
- Review, Var, NA
RadioS↑, ChemoSen↑, chemoP↑, *lipid-P↓, *Catalase↑, *SOD↑, *GPx↑, *GSTs↑, *GSH↑, *TNF-α↓, *IL1β↓, *Casp3↓, *IL10↑, NRF2↓, HO-1↓, NQO1↓, GSH↓, MET↓, p‑MET↓, p‑Akt↓, HGF/c-Met↓, NF-kB↓, Bcl-2↓, SOD2↓, Casp8↑, Casp3↑, PARP↑, MAPK↓, NLRP3↓, ASC↓, Casp1↓, IL6↓, IKKα↓, p‑p65↓, p‑p38↑, MMP2↓, ICAM-1↓, EGFR↑, p‑PI3K↓, E-cadherin↓, ZO-1↑, N-cadherin↓, CLDN1↓, β-catenin/ZEB1↓, Snail↓, Vim↑, ITGB1↓, FAK↓, p‑Src↓, Rac1↓, Cdc42↓, Rho↓, PCNA↓, Tyro3↓, AXL↓, CEA↓, NSE↓, SOD↓, Catalase↓, GPx↓, GSR↓, GSTs↓, GSH↓, VitE↓, VitC↓, CYP1A1↓, cFos↑, AR↓, AIF↑, p‑STAT6↓, p‑MDM2↓, NOTCH1↓, VEGF↓, H3↓, H4↓, HDAC↓, SIRT1↓, ROS↑, DR5↑, Cyt‑c↑, p‑JNK↑, PTEN↓, mTOR↓, CD34↓, FasL↑, Fas↑, XIAP↓, p‑eIF2α↑, CHOP/DDIT3↑, LC3II↑, PD-1↓, STAT3↓, IL2↑, EMT↓, cachexia↓, BioAv↑, *Half-Life↝, *eff↑,
1196- MAG,    2-O-Methylmagnolol, a Magnolol Derivative, Suppresses Hepatocellular Carcinoma Progression via Inhibiting Class I Histone Deacetylase Expression
- in-vitro, HCC, NA
TumCG↓, TumCMig↓, TumCI↓, TumCCA↑, HDAC↓,
998- PB,    Phenyl butyrate inhibits pyruvate dehydrogenase kinase 1 and contributes to its anti-cancer effect
- in-vivo, Var, NA
p‑PDH↓, PDH↑, PDK1 / PDPK1↓, HDAC↓, Glycolysis↓, MMP↓, Apoptosis↑,
2052- PB,    Lipid-regulating properties of butyric acid and 4-phenylbutyric acid: Molecular mechanisms and therapeutic applications
- Review, Nor, NA
*HDAC↓, *Half-Life↑, *Half-Life↑, *lipoGen↓, *ER Stress↓, *FAO↑, *ROS↓, *BioAv↑,
2054- PB,    Sodium butyrate induces ferroptosis in endometrial cancer cells via the RBM3/SLC7A11 axis
- in-vitro, EC, ISH - in-vitro, EC, HEC1B
Ferroptosis↑, xCT/SLC7A11↓, RBM3↑, HDAC↓, ROS↑,
2061- PB,  Chemo,    Complementary effects of HDAC inhibitor 4-PB on gap junction communication and cellular export mechanisms support restoration of chemosensitivity of PDAC cells
- in-vitro, PC, PANC1 - in-vitro, PC, COLO357 - in-vitro, PC, Bxpc-3
HDAC↓, Apoptosis↑, eff↑, selectivity↑, TumCCA↑, eff↑, selectivity↑,
2064- PB,  Rad,    Phenylbutyrate Attenuates the Expression of Bcl-XL, DNA-PK, Caveolin-1, and VEGF in Prostate Cancer Cells
- in-vitro, Pca, PC3 - in-vitro, Pca, DU145 - in-vitro, Pca, LNCaP
Bcl-xL↓, Cav1↓, VEGF↓, RadioS↑, chemoP↑, HDAC↓, *toxicity↓, Diff↑, Prot↓,
2067- PB,    Histone Deacetylase (HDAC) Inhibitors: Current Evidence for Therapeutic Activities in Pancreatic Cancer
- in-vitro, PC, NA
HDAC↓, HATs↑,
2074- PB,  Chemo,    The effect of combined treatment with sodium phenylbutyrate and cisplatin, erlotinib, or gefitinib on resistant NSCLC cells
- in-vitro, Lung, A549 - in-vitro, Lung, Calu-6 - in-vitro, Lung, H1650
TumCG↓, Synergy↑, ChemoSen↑, HDAC↓,
2075- PB,  Chemo,    Preliminary Findings on the Use of Targeted Therapy in Combination with Sodium Phenylbutyrate in Colorectal Cancer after Failure of Second-Line Therapy—A Potential Strategy for Improved Survival
- Trial, CRC, NA
OS↑, HDAC↓,
2077- PB,    Butyrate induces ROS-mediated apoptosis by modulating miR-22/SIRT-1 pathway in hepatic cancer cells
- in-vitro, Liver, HUH7
miR-22↑, SIRT1↓, ROS↑, Cyt‑c↑, Casp3↑, eff↓, TumCG↓, TumCP↓, HDAC↓, SIRT1↓, CD44↓, proMMP2↓, MMP↓, SOD↓,
2048- PB,    Sodium Phenylbutyrate Inhibits Tumor Growth and the Epithelial-Mesenchymal Transition of Oral Squamous Cell Carcinoma In Vitro and In Vivo
- in-vitro, OS, CAL27 - in-vitro, Oral, HSC3 - in-vitro, OS, SCC4 - in-vivo, NA, NA
*NH3↓, *HDAC↓, *ER Stress↓, Apoptosis?, Bcl-2↓, cl‑Casp3↑, TGF-β↑, N-cadherin↓, E-cadherin↑, TumVol↓, ChemoSen↑,
2049- PB,    Modifying histones to tame cancer: clinical development of sodium phenylbutyrate and other histone deacetylase inhibitors
- Review, Var, NA
HDAC↓, ac‑H3↑, ac‑H4↑, ac‑H3↑, eff↝, toxicity↓,
2026- PB,    Oral sodium phenylbutyrate in patients with recurrent malignant gliomas: A dose escalation and pharmacologic study
- Trial, GBM, NA
Dose↝, Dose↑, Dose↝, OS↑, HDAC↓, TumCCA↑, P21↑, other↝, BioAv↑, eff↑,
2027- PB,    Phase I dose escalation clinical trial of phenylbutyrate sodium administered twice daily to patients with advanced solid tumors
- Trial, Var, NA
TumCG↓, Dose↝, toxicity↓, Dose↝, HDAC↓, OS↑,
2028- PB,    Potential of Phenylbutyrate as Adjuvant Chemotherapy: An Overview of Cellular and Molecular Anticancer Mechanisms
- Review, Var, NA
HDAC↓, TumCCA↑, P21↑, Dose↝, Telomerase↓, IGFBP3↑, p‑p38↑, JNK↑, ERK↑, BAX↑, Casp3↑, Bcl-2↓, Cyt‑c↝, FAK↓, survivin↓, VEGF↓, angioG↓, DNArepair↓, TumMeta↓, HSP27↑, ASK1↑, ROS↑, eff↑, ER Stress↓, GRP78/BiP↓, CHOP/DDIT3↑, AR↓, other?,
2029- PB,    Phenylbutyric Acid: simple structure - multiple effects
- Review, Var, NA
NH3↓, HDAC↓, ChemChap↑,
2030- PB,    4-Phenylbutyric acid protects against neuronal cell death by primarily acting as a chemical chaperone rather than histone deacetylase inhibitor
- Review, Nor, NA
*HDAC↓, *neuroP↑, *ChemChap↑,
2031- PB,    Phenylbutyrate is a multifaceted drug that exerts neuroprotective effects and reverses the Alzheimer´s disease-like phenotype of a commonly used mouse model
- in-vivo, AD, NA
*neuroP↑, *HDAC↓, *ChemChap↑,
2035- PB,    Sodium Phenylbutyrate Controls Neuroinflammatory and Antioxidant Activities and Protects Dopaminergic Neurons in Mouse Models of Parkinson’s Disease
- in-vitro, Nor, glial - in-vivo, NA, NA
*ROS↓, *Inflam↑, *P21↓, *antiOx↑, *GSH↑, *NF-kB↓, *neuroP↑, *HDAC↓, *iNOS↓, *TNF-α↓, *IL1β↓, *LDL↓, ROS↓,
2039- PB,    TXNIP mediates the differential responses of A549 cells to sodium butyrate and sodium 4‐phenylbutyrate treatment
- in-vitro, Lung, A549 - in-vitro, Nor, HEK293
TXNIP↑, Casp3↑, Casp7↑, mt-ROS↑, GlucoseCon↓, TumCP↓, TumCD↑, IGF-2↑, HDAC↓, ROS⇅,
2042- PB,    Phenylbutyrate, a histone deacetylase inhibitor, protects against Adriamycin-induced cardiac injury
- in-vitro, Nor, NA
*HDAC↓, *toxicity↓, *LDH↓, *SOD2↑, *ROS↓, *cardioP↑, *antiOx↑,
2043- PB,  Cisplatin,    Phenylbutyrate interferes with the Fanconi anemia and BRCA pathway and sensitizes head and neck cancer cells to cisplatin
- in-vitro, HNSCC, UM-SCC-1
ChemoSen↑, eff↑, HDAC↓, BRCA1↓, RadioS↑,
2045- PB,    Phenylbutyrate—a pan-HDAC inhibitor—suppresses proliferation of glioblastoma LN-229 cell line
- in-vitro, GBM, LN229 - in-vitro, GBM, LN-18
HDAC↓, TumCG↓, TumCCA↑, P21↑, Bcl-2↓, Bcl-xL↓, BioAv↑,
2046- PB,    Sodium butyrate promotes apoptosis in breast cancer cells through reactive oxygen species (ROS) formation and mitochondrial impairment
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-468 - in-vitro, Nor, MCF10
Apoptosis↑, i-ROS?, Casp↑, MMP?, selectivity↑, *ROS∅, HDAC↓, DNArepair↓, Casp3↑, Casp8↑, *toxicity↓, TumCCA↑,
1660- PBG,    Emerging Adjuvant Therapy for Cancer: Propolis and its Constituents
- Review, Var, NA
MMPs↓, angioG↓, TumMeta↓, TumCCA↑, Apoptosis↑, ChemoSideEff↓, eff∅, HDAC↓, PTEN↑, p‑PTEN↓, p‑Akt↓, Casp3↑, p‑ERK↑, p‑FAK↑, Dose?, Akt↓, GSK‐3β↓, FOXO3↓, ChemoSen↑, IL2↑, IL10↑, NF-kB↓, VEGF↓, mtDam↑, ER Stress↑, AST↓, ALAT↓, ALP↓, COX2/PTGS2↓, eff↑, Bax:Bcl2↑,
1666- PBG,    Molecular and Cellular Mechanisms of Propolis and Its Polyphenolic Compounds against Cancer
- Review, Var, NA
ChemoSen↑, TumCCA↑, TumCP↓, Apoptosis↑, antiOx↓, ROS↑, COX2/PTGS2↑, ER(estro)↓, cycA1/CCNA1↓, CycB/CCNB1↓, CDK2↓, P21↑, p27/CDKN1B↑, hTERT/TERT↓, HDAC↓, ROS⇅, Dose?, ROS↓, ROS↑, DNAdam↑, ChemoSen↑, LOX1↓, lipid-P↓, NO↑, Igs↑, NK cell↑, MMPs↓, VEGF↓, Hif1a↓, GLUT1↓, HK2↓, selectivity↑, RadioS↑, GlucoseCon↓, lactateProd↓, eff↓, *BioAv↓,
4921- PEITC,    The Potential Use of Phenethyl Isothiocyanate for Cancer Prevention
- Review, Var, NA
antiOx↑, Inflam↓, AntiCan↑, TumCP↓, TumCCA↑, Apoptosis↑, TumAuto↑, HDAC↓, Risk↓,
4928- PEITC,    Dietary phytochemical PEITC restricts tumor development via modulation of epigenetic writers and erasers
- vitro+vivo, Colon, SW-620
Risk↓, HDAC↓, TumW↓, TumCG↓, AP-1↓, cAMP↓, NF-kB↓, BMI1↓, SUZ12↓, EZH2↓, selectivity↑,

Showing Research Papers: 51 to 100 of 158
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 158

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 3,   Catalase↓, 2,   Catalase↑, 1,   GPx↓, 1,   GPx4↓, 1,   GSH↓, 8,   GSH↑, 1,   i-GSH∅, 1,   GSR↓, 1,   GSS↑, 1,   GSTs↓, 1,   HO-1↓, 4,   HO-1↑, 5,   Iron↑, 1,   lipid-P↓, 3,   lipid-P↑, 2,   MDA↑, 1,   NADH↓, 1,   NQO1?, 1,   NQO1↓, 1,   NQO1↑, 3,   NRF2↓, 4,   NRF2↑, 16,   NRF2∅, 1,   ROS?, 1,   ROS↓, 6,   ROS↑, 46,   ROS⇅, 4,   i-ROS?, 1,   mt-ROS↑, 1,   SOD↓, 3,   SOD2↓, 1,   VitC↓, 1,   VitE↓, 1,   xCT/SLC7A11↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Mets↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC25↓, 1,   ETC↓, 1,   Insulin↓, 1,   mtDam↑, 3,   OXPHOS↓, 1,   OXPHOS↑, 1,   mt-OXPHOS↓, 2,   PDH↑, 1,   p‑PDH↓, 1,   PINK1↑, 1,   SIRT3↓, 1,   SIRT3↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 2,   AMPK↑, 5,   ATP↓, 4,   ATP↑, 1,   Buty↑, 1,   cAMP↓, 1,   FASN↓, 1,   G6PD↓, 1,   GAPDH↓, 1,   GLS↓, 1,   glucoNG↓, 1,   GlucoseCon↓, 3,   GlutMet↓, 1,   Glycolysis↓, 8,   GSK‐3β↓, 2,   GSK‐3β↑, 1,   p‑GSK‐3β↓, 2,   Histones↝, 1,   HK2↓, 6,   HMG-CoA↓, 2,   lactateProd↓, 1,   lactateProd↑, 1,   LDHA↓, 1,   LDL↓, 2,   NADPH↑, 1,   NH3↓, 1,   PA↑, 1,   PDK1 / PDPK1↓, 3,   PKM2↓, 3,   PKM2↑, 1,   RARβ↑, 1,   SCD1↓, 1,   SCFAs↑, 1,   SIRT1↓, 6,   SIRT1↑, 3,   SREBP1/SREBF1↓, 1,   SREBP2↓, 2,   Warburg↓, 6,  

Cell Death(tgid=5) ⓘ

AIF↑, 3,   APAF1↑, 2,   Apoptosis?, 1,   Apoptosis↓, 1,   Apoptosis↑, 38,   ASC↓, 1,   ASK1↑, 1,   BAD↑, 1,   Bak↑, 3,   BAX↑, 22,   BAX⇅, 1,   Bax:Bcl2↑, 7,   Bcl-2↓, 27,   Bcl-xL↓, 16,   BID↑, 2,   BIM↓, 1,   BIM↑, 2,   BNIP3↑, 1,   Casp↑, 10,   Casp1↓, 1,   Casp12?, 1,   Casp12↑, 1,   Casp3↓, 1,   Casp3↑, 29,   Casp3↝, 1,   cl‑Casp3↑, 4,   Casp7↑, 4,   cl‑Casp7↑, 1,   Casp8↑, 4,   Casp8∅, 1,   Casp9↑, 15,   cl‑Casp9↑, 1,   cFLIP↓, 2,   Cyt‑c↓, 1,   Cyt‑c↑, 20,   Cyt‑c↝, 1,   Diablo↑, 3,   DR5↑, 5,   Fas↑, 1,   FasL↑, 1,   Ferroptosis↑, 2,   IAP1↓, 4,   IAP1↑, 1,   IAP2/BIRC3↓, 2,   ICAD↑, 1,   iNOS↓, 4,   Mcl-1↓, 4,   Mcl-1↑, 1,   MDM2↑, 1,   p‑MDM2↓, 1,   Necroptosis↑, 1,   NOXA↑, 1,   p38↓, 1,   p38↑, 3,   p‑p38↑, 2,   PUMA↑, 1,   survivin↓, 16,   TRAIL↑, 2,   TumCD↑, 2,   TUNEL↑, 1,   XIAP↓, 9,   YAP/TEAD↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 19,   p‑Akt↓, 6,   AKT1↓, 1,   AMPKα↑, 1,   CaMKII ↑, 1,   CK2↓, 2,   p‑cMET↑, 1,   cSrc↓, 1,   EF-1α↓, 1,   EGFR↓, 7,   EGFR↑, 1,   ERK↓, 7,   ERK↑, 2,   p‑ERK↓, 3,   p‑ERK↑, 1,   HCAR2↑, 4,   HER2/EBBR2↓, 5,   HGF/c-Met↓, 2,   IKKα↓, 2,   JAK2↓, 1,   JNK↓, 1,   JNK↑, 3,   p‑JNK↑, 1,   MAPK↓, 8,   MAPK↑, 2,   MEK↓, 1,   mTOR↓, 10,   mTOR↑, 1,   mTOR∅, 1,   p‑mTOR↓, 3,   p70S6↓, 1,   PI3K↓, 13,   p‑PI3K↓, 2,   PKA↓, 1,   PKCδ↓, 2,   PTEN↓, 1,   PTEN↑, 9,   p‑PTEN↓, 1,   Raf↓, 1,   c-Raf↓, 1,   RAS↓, 1,   RAS↑, 1,   Sp1/3/4↓, 1,   Src↓, 1,   p‑Src↓, 1,   STAT3↓, 13,   STAT3↑, 1,   p‑STAT3↓, 3,   p‑STAT3↑, 2,   STAT5↓, 2,   p‑STAT6↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF4↑, 1,   cJun↑, 2,   cMyc↓, 8,   DNMT1↓, 13,   DNMT3A↓, 11,   DNMTs↓, 25,   DNMTs⇅, 1,   EZH2↓, 6,   FOXO↑, 2,   FOXO1↓, 1,   FOXO3↓, 1,   FOXO3↑, 2,   H3↓, 2,   H3↑, 3,   ac‑H3↓, 2,   ac‑H3↑, 13,   ac‑H3↝, 1,   H4↓, 1,   H4↑, 3,   ac‑H4↓, 2,   ac‑H4↑, 9,   HATs↓, 6,   HATs↑, 7,   HATs⇅, 1,   HDAC↓, 140,   HDAC↑, 1,   HDAC⇅, 1,   HDAC∅, 1,   HDAC1↓, 14,   HDAC11↓, 1,   HDAC2↓, 7,   HDAC3↓, 9,   HDAC4↓, 2,   HDAC6↓, 1,   HDAC8↓, 6,   HMTs↓, 3,   HMTs↑, 1,   KLF4↓, 1,   MeCP2↓, 1,   miR-139-5p↑, 1,   miR-155↓, 1,   miR-200c↑, 1,   miR-203↑, 1,   miR-22↑, 1,   miR-30a-5p↑, 1,   OCT4↓, 3,   other?, 1,   other↓, 1,   other↝, 3,   PRC2↓, 1,   Prot↓, 1,   SOX2↓, 1,   SOX4↓, 1,   SOX9↓, 1,   SUZ12↓, 1,   TET3↑, 1,   tumCV↓, 7,  

Protein Folding & ER Stress(tgid=8) ⓘ

ChemChap↑, 1,   CHOP/DDIT3↑, 4,   cl‑CHOP/DDIT3↑, 1,   eIF2α↑, 1,   p‑eIF2α↑, 2,   ER Stress↓, 1,   ER Stress↑, 9,   GRP78/BiP↓, 1,   GRP78/BiP↑, 4,   HSP27↑, 2,   HSP70/HSPA5↓, 1,   HSP90↓, 2,   ac‑HSP90↑, 1,   p‑PERK↑, 1,   UPR↑, 1,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG3↑, 1,   ATG5↑, 1,   ATG7↑, 1,   Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 1,   LAMP2↑, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3II↑, 4,   p62↓, 2,   p62↑, 1,   PARK2↑, 1,   TumAuto↑, 7,  

DNA Damage & Repair(tgid=10) ⓘ

BRCA1↓, 1,   BRCA1↑, 2,   DNAdam↑, 8,   DNArepair↓, 3,   G9a↓, 3,   hTERT/TERT↓, 9,   MGMT↓, 1,   p16↑, 2,   P53↑, 16,   PARP↓, 1,   PARP↑, 3,   cl‑PARP↑, 12,   PARP1↑, 1,   PCNA↓, 7,   PCNA↝, 1,   SIRT6↓, 1,   Telomerase↓, 7,   TOP1↓, 1,   UHRF1↓, 1,   γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1,   CDK1↑, 2,   CDK2↓, 8,   CDK2↑, 1,   CDK4↓, 9,   CDK6↓, 3,   CDKN1C/p57↑, 1,   p‑Chk2↑, 1,   Cyc↓, 2,   cycA1/CCNA1↓, 2,   CycB/CCNB1↓, 3,   cycD1/CCND1↓, 15,   cycD1/CCND1↑, 1,   CycD3↓, 1,   cycE/CCNE↓, 1,   GADD45A↑, 2,   Ki-67↓, 5,   p19↑, 2,   P21?, 1,   P21↑, 26,   p27/CDKN1B↑, 6,   pRB↑, 1,   p‑RB1↓, 2,   TumCCA?, 2,   TumCCA↓, 1,   TumCCA↑, 44,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 1,   ALDH1A1↓, 1,   BMI1↓, 2,   BMPs↑, 1,   CD133↓, 3,   CD34↓, 2,   cFos↑, 1,   cMYB↓, 1,   CSCs↓, 7,   Diff↑, 3,   FGF↓, 1,   Gli↓, 1,   Gli1↓, 1,   HMGCR↓, 1,   IGF-1↓, 3,   IGF-2↑, 1,   IGFBP3↑, 2,   Jun↓, 1,   Ki-67↓, 5,   Let-7↑, 1,   mTORC1↓, 1,   Nanog↓, 3,   Nestin↓, 2,   Neurog1↑, 1,   NOTCH↓, 4,   NOTCH1↓, 2,   NOTCH1↑, 1,   NOTCH3↓, 1,   p300↓, 2,   Shh↓, 2,   Smo↓, 1,   TOPflash↑, 1,   TumCG↓, 23,   TumCP↓, 23,   TumCP⇅, 1,   Wnt↓, 5,  

Migration(tgid=13) ⓘ

67LR↓, 1,   AntiAg?, 1,   AntiAg↓, 1,   AP-1↓, 5,   AXL↓, 1,   CA↓, 1,   Ca+2↑, 5,   Cav1↓, 1,   Cdc42↓, 1,   CDH1↑, 1,   DLC1↑, 1,   E-cadherin↓, 1,   E-cadherin↑, 11,   EMT?, 1,   EMT↓, 14,   FAK↓, 9,   p‑FAK↑, 1,   Fibronectin↓, 1,   ITGB1↓, 1,   MET↓, 1,   p‑MET↓, 1,   MMP-10↓, 1,   MMP1↓, 1,   MMP2↓, 17,   proMMP2↓, 1,   MMP7↓, 1,   MMP9↓, 20,   MMPs↓, 13,   MUC4↓, 3,   N-cadherin↓, 5,   PDGF↓, 2,   Rac1↓, 1,   Rho↓, 1,   Slug↓, 1,   Smad1↑, 1,   Snail↓, 5,   TET1↑, 3,   TGF-β↓, 4,   TGF-β↑, 2,   TIMP1↑, 2,   TIMP2↑, 2,   TIMP3↑, 1,   TSP-1↑, 1,   TumCA↑, 1,   TumCI?, 1,   TumCI↓, 11,   TumCMig↓, 11,   TumMeta↓, 14,   TumMeta↑, 1,   Twist↓, 7,   TXNIP↑, 2,   Tyro3↓, 1,   uPA↓, 6,   Vim↓, 5,   Vim↑, 1,   Zeb1↓, 6,   α-tubulin↑, 1,   ac‑α-tubulin↑, 1,   β-catenin/ZEB1↓, 7,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 23,   CD31/PECAM-1↓, 1,   eNOS↓, 1,   HIF-1↓, 1,   Hif1a↓, 21,   LOX1↓, 1,   NO↓, 1,   NO↑, 1,   VEGF↓, 27,   VEGFR2/KDR/Flk1↓, 5,  

Barriers & Transport(tgid=15) ⓘ

CLDN1↓, 3,   CLDN2↓, 1,   GLUT1↓, 4,   MMP?, 1,   MMP↓, 20,   MMP↑, 1,   NHE1↓, 1,   SLC12A5↝, 1,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

B2M↓, 1,   CD44↓, 5,   CD8+↑, 1,   COX1↓, 1,   COX2/PTGS2↓, 23,   COX2/PTGS2↑, 2,   CXCL12↓, 1,   CXCR4↓, 3,   CXCR4↑, 1,   HCAR2↑, 4,   ICAM-1↓, 1,   IFN-γ↑, 3,   Igs↑, 1,   IL1↓, 1,   IL10↓, 3,   IL10↑, 1,   IL12↑, 1,   IL18↓, 1,   IL1β↓, 6,   IL2↓, 1,   IL2↑, 4,   IL6↓, 8,   IL8↓, 3,   Imm↑, 2,   Inflam↓, 5,   M2 MC↓, 1,   MCP1/CCL2↓, 2,   MCT1↓, 1,   MDSCs↓, 1,   NAF1↓, 1,   NF-kB↓, 31,   NF-kB↑, 1,   NK cell↑, 2,   NLRP3↓, 3,   p65↓, 1,   p‑p65↓, 1,   PD-1↓, 1,   PD-L1↓, 1,   PGE1↓, 1,   PGE2↓, 4,   PSA↓, 2,   SOCS1↑, 1,   TLR4↓, 1,   TNF-α↓, 11,   Treg lymp↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 4,   COMT↑, 1,   CYP11A1↓, 1,   ER-α36↓, 1,   ER(estro)↓, 1,   PPARα↓, 1,   cl‑PPARα↓, 1,   PPARγ↓, 3,   PPARγ↑, 1,   VDR↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 8,   BioAv↑, 8,   BioAv↝, 4,   BioEnh↑, 1,   ChemoSen↑, 33,   CompStab↝, 1,   CYP1A1↓, 3,   CYP1B1↑, 1,   CYP3A4↓, 1,   Dose?, 2,   Dose↑, 2,   Dose↝, 19,   Dose∅, 2,   eff↓, 9,   eff↑, 24,   eff↝, 4,   eff∅, 1,   GSTA1↑, 1,   Half-Life↓, 3,   Half-Life↝, 2,   Half-Life∅, 1,   P-gp/ABCB1↓, 2,   P450↓, 1,   RadioS↑, 8,   selectivity?, 1,   selectivity↑, 26,   Synergy↑, 30,   TET2↓, 1,   TET2↑, 2,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 2,   ALP↓, 2,   AR↓, 4,   AST↓, 1,   B2M↓, 1,   BG↓, 1,   BRCA1↓, 1,   BRCA1↑, 2,   CEA↓, 1,   EGFR↓, 7,   EGFR↑, 1,   EZH2↓, 6,   HER2/EBBR2↓, 5,   hTERT/TERT↓, 9,   IL6↓, 8,   LDH↓, 1,   Maspin↑, 2,   NSE↓, 1,   PD-L1↓, 1,   PSA↓, 2,   RBM3↑, 1,   SUZ12↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 12,   AntiTum↑, 4,   cachexia↓, 1,   cardioP↑, 4,   CardioT↓, 2,   chemoP↑, 8,   chemoPv↑, 6,   ChemoSideEff↓, 3,   cognitive↑, 1,   hepatoP↑, 6,   K17↓, 1,   neuroP↑, 7,   OS↑, 7,   Remission↑, 2,   RenoP↑, 3,   Risk↓, 7,   toxicity↓, 3,   toxicity↝, 1,   toxicity∅, 1,   TumVol↓, 7,   TumW↓, 6,   Weight↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

GutMicro↑, 6,   GutMicro↝, 1,  
Total Targets: 576

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 17,   ARE↑, 1,   Catalase↑, 7,   GPx↑, 4,   GSH↑, 9,   GSR↑, 1,   GSTs↑, 4,   HDL↑, 1,   HO-1↑, 5,   lipid-P↓, 2,   MDA↓, 2,   MPO↑, 1,   NQO1↑, 1,   Nrf1↑, 1,   NRF2↑, 10,   RNS↓, 1,   ROS↓, 26,   ROS↝, 1,   ROS∅, 1,   SAM-e↑, 1,   SOD↑, 7,   SOD1↑, 1,   SOD2↑, 2,   TBARS↓, 1,   VitC↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compI↑, 1,   PGC-1α↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 1,   ATP↑, 1,   ATP↝, 1,   cytoP450↓, 1,   FABP4↓, 1,   FAO↑, 1,   GSK‐3β↓, 1,   LDL↓, 1,   lipoGen↓, 1,   NAD↑, 1,   NAD↝, 1,   NADPH↓, 1,   NH3↓, 1,   SIRT1↑, 2,   SREBF2⇅, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 3,   Casp3↓, 2,   Cyt‑c↓, 1,   IAP1↓, 1,   iNOS↓, 5,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↑, 2,   AMPKα↑, 1,   CREB↑, 1,   ERK↑, 1,   HCAR2↑, 1,   IGF-1R↓, 1,   IKKα↑, 1,   JAK↓, 1,   JNK↓, 1,   MAPK↓, 1,   PDGFR-BB↓, 1,   PKCδ↓, 1,   PKCδ↑, 1,   PTEN↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 1,   DNMT1↓, 2,   DNMT3A↓, 2,   DNMTs↓, 2,   ac‑H3↑, 1,   ac‑H4↑, 1,   HATs↓, 1,   HDAC↓, 15,   HDAC↑, 3,   HDAC2↓, 1,   HDAC3↓, 2,   other↓, 1,   other↑, 1,   other↝, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ChemChap↑, 2,   ER Stress↓, 2,   HSP27↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

P53↓, 1,   Telomerase↓, 1,   TOP1↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

E2Fs↑, 1,   Ki-67↓, 1,   P21↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMPs↑, 1,   CEBPA↓, 1,   Ki-67↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↓, 2,   AP-1↓, 2,   Ca+2↝, 1,   MMP13↓, 1,   MMP2↓, 1,   p‑Rac1↓, 1,   serineP↓, 1,   TGF-β1↓, 1,   TIMP1↓, 1,   uPA↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

Hif1a↓, 1,   NO↓, 3,   VEGF↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 2,   CLDN1↑, 1,   memfluid↑, 1,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 6,   CXCR2↑, 1,   HCAR2↑, 1,   IFN-γ↓, 2,   IL1↓, 1,   IL10↓, 1,   IL10↑, 5,   IL17↓, 3,   IL1β↓, 8,   IL22↓, 1,   IL4↑, 1,   IL6↓, 9,   IL8↓, 3,   Imm↝, 1,   Inflam↓, 20,   Inflam↑, 2,   LTA/TNF-β↑, 1,   MCP1/CCL2↓, 1,   NF-kB↓, 11,   PGE2↓, 2,   TNF-α↓, 14,   VitD↑, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 2,   BChE↓, 1,   BDNF↑, 2,   MAOA↓, 1,   MAOB↓, 1,   TrkB↑, 2,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 2,   tau↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

GR↑, 1,   PPARγ↓, 1,   testos↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv?, 1,   BioAv↓, 9,   BioAv↑, 11,   BioAv↝, 4,   ChemoSen↑, 1,   CompStab↑, 1,   Dose↑, 1,   Dose↝, 2,   eff↓, 1,   eff↑, 5,   GSTA1↑, 1,   Half-Life↑, 2,   Half-Life↝, 4,   Half-Life∅, 1,   P-gp/ABCB1↓, 1,   P450↓, 1,   selectivity↑, 1,   Synergy↑, 4,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   ALP↓, 1,   AST↓, 2,   BMD↑, 1,   Calcium↑, 1,   CRP↓, 1,   hs-CRP↓, 1,   IL6↓, 9,   LDH↓, 1,   Mag↑, 1,   TMAO↓, 1,   VitD↑, 1,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 1,   AntiAge↑, 1,   antiAll↑, 1,   AntiArt↑, 1,   AntiCan↑, 3,   antiPs↑, 1,   cardioP↑, 7,   chemoP↑, 3,   chemoPv↑, 1,   ChemoSideEff↓, 1,   cognitive↑, 4,   diuretic↑, 1,   hepatoP↓, 1,   hepatoP↑, 3,   memory↑, 4,   neuroP↑, 12,   Obesity↓, 1,   Pain↓, 1,   radioP↑, 6,   RenoP↑, 2,   Risk↓, 1,   Stroke↓, 1,   toxicity↓, 9,   toxicity↝, 1,   toxicity∅, 2,  

Infection & Microbiome(tgid=24) ⓘ

AntiFungal↑, 1,   AntiViral↑, 1,   Bacteria↓, 2,   Diar↓, 1,   GutMicro↑, 2,  
Total Targets: 197

Scientific Paper Hit Count for: HDAC, Histone deacetylases
34 Sulforaphane (mainly Broccoli)
23 Phenylbutyrate
14 Thymoquinone
12 Butyrate
10 EGCG (Epigallocatechin Gallate)
7 Apigenin (mainly Parsley)
6 Curcumin
4 Chrysin
4 Chemotherapy
4 Luteolin
4 Quercetin
3 Berberine
3 Boron
3 Honokiol
3 Resveratrol
3 Silymarin (Milk Thistle) silibinin
2 Ashwagandha(Withaferin A)
2 Atorvastatin
2 Radiotherapy/Radiation
2 Emodin
2 Inulin Prebiotic
2 Cisplatin
2 Propolis -bee glue
2 Phenethyl isothiocyanate
1 3-bromopyruvate
1 Allicin (mainly Garlic)
1 Acetyl-l-carnitine
1 alpha Linolenic acid
1 Andrographis
1 Betulinic acid
1 chaetocin
1 diet FMD Fasting Mimicking Diet
1 Diindolylmethane
1 Indole-3-carbinol
1 Formononetin
1 Gambogic Acid
1 Genistein (soy isoflavone)
1 Kaempferol
1 Magnolol
1 Piperlongumine
1 Polyphenols
1 Vorinostat
1 diet Plant based
1 Gemcitabine (Gemzar)
1 Vitamin D3
1 doxorubicin
1 Selenite (Sodium)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:140  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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