chemoPv Cancer Research Results

chemoPv, ChemoPreventive: Click to Expand ⟱
Source:
Type:
Chemopreventive: An agent that lowers the probability of cancer development or delays progression from premalignant states.
Mechanisms
-Reduce DNA damage / mutagenesis
-Enhance detoxification or repair
-Modulate hormones or inflammation
-Promote differentiation or apoptosis of abnormal cells


Scientific Papers found: Click to Expand⟱
2788- CHr,    Chrysin: Sources, beneficial pharmacological activities, and molecular mechanism of action
- Review, Var, NA
*neuroP↑, *Inflam↓, *ROS↓, NF-kB↓, *PCNA↓, *COX2↓, ChemoSen↑, Hif1a↓, angioG↓, *chemoPv↑, PDGF↓, *memory↑, *RenoP↑, *PPARα↑, *lipidLev↓, *hepatoP↑, *cardioP⇅, *BioAv↓,
6144- Cin,    The Cinnamon-Derived Dietary Factor Cinnamic Aldehyde Activates the Nrf2-Dependent Antioxidant Response in Human Epithelial Colon Cells
- in-vitro, Colon, HCT116
Nrf1↑, HO-1↑, chemoPv↑,
4762- CoQ10,    The role of coenzyme Q10 as a preventive and therapeutic agent for the treatment of cancers
- Review, Var, NA
*AntiCan↓, *ROS↓, chemoPv↑, TumCCA↑, Apoptosis↑, TumCP↓, angioG↓, MMPs↓, ChemoSen∅,
6373- CPLE,    Anticancer Activity of Phytochemicals of the Papaya Plant Assessed: A Narrative Review
- Review, Var, NA
chemoPv↑, TumCP↓, angioG↓, TumMeta↓, ROS↑, Dose↝,
5801- CRMs,  Chemo,    Caloric Restriction Enhances Chemotherapy Efficacy and Reshapes Stress Responses in Sarcoma
- in-vivo, sarcoma, NA
TumCG↓, *hepatoP↑, *ROS↓, *OS↑, ChemoSen↑, chemoPv↑, selectivity↑, *DNAdam↓,
6294- Cro,    Crocetin and Crocin from Saffron in Cancer Chemotherapy and Chemoprevention
- Review, Var, NA
*chemoPv↑, *antiOx↑, Apoptosis↑, TumCP↓, Diff↑, TumCCA↑, TumCG↓, TOP2↓, hTERT/TERT↓, Inflam↓, IL1β↓, TNF-α↓, Casp8↑, BAX↑, Cyt‑c↑, ChemoSen↑, RadioS↑, Apoptosis↑, cycD1/CCND1↓, P21↑, p27↑, Bcl-2↓, Bax:Bcl2↑, Casp9↑, EMT↓, E-cadherin↑, β-catenin/ZEB1↓, N-cadherin↓,
6527- CRV,    Preventive effect of D-carvone during DMBA induced mouse skin tumorigenesis by modulating xenobiotic metabolism and induction of apoptotic events
- in-vivo, Melanoma, NA
AntiTum↑, P450↓, GSR↑, GSTs↑, GSH↑, BAX↑, Casp3↑, Casp9↑, Bcl-2↓, p53 Wildtype↓, chemoPv↑, Apoptosis↑,
6195- Cuc,    Cucurbitacins as Potent Chemo-Preventive Agents: Mechanistic Insight and Recent Trends
- Review, Var, NA
TumCG↓, Apoptosis↑, TumCCA↑, TumMeta↓, angioG↓, chemoPv↑, BioAv↓, Half-Life↝, cycD1/CCND1↓, cycE/CCNE↓, Casp3↑, cl‑PARP↑, JNK↑, Akt↓, ERK↓, survivin↓, XIAP↓, Bcl-2↓, Mcl-1↓, ROS↑, NRF2↓, FAK↓, MMP9↓, VEGF↓, VEGFR2↓, *NF-kB↓, TLR4↝, NLRP3↑, Pyro↑, GSH↓,
6202- Cuc,    Cucurbitacins as potential anticancer agents: new insights on molecular mechanisms
- Review, Var, NA
*Inflam↓, *antiOx↑, *hepatoP↑, AntiTum↑, AntiCan↑, *chemoPv↑, *AntiDiabetic↑, *Imm↑, Hif1a↓, P-gp↓, mTORC1↓, ERK↓, Akt↓, Casp3↑, Casp7↑, ATP↓, RadioS↑, ChemoSen↑,
4654- CUR,    Stem Cell Therapy: Curcumin Does the Trick
- Review, Var, NA
*antiOx↑, *Inflam↓, AntiCan↑, chemoPv↑, *AntiAge↑, *neuroP↑, *Wound Healing↑,
4708- CUR,    Molecular mechanisms underlying curcumin-mediated microRNA regulation in carcinogenesis; Focused on gastrointestinal cancers
- Review, GC, NA
chemoPv↑, AntiCan↑, *antiOx↑, *Inflam↓, miR-21↓, miR-34a↑, miR-200b↑, miR-27a-3p↓,
161- CUR,  MeSA,    Enhanced apoptotic effects by the combination of curcumin and methylseleninic acid: potential role of Mcl-1 and FAK
- in-vitro, BC, MDA-MB-231 - in-vitro, Pca, DU145
Mcl-1↑, Mcl-1↓, MPT↑, AIF↑, chemoPv↑, Apoptosis↑, ROS↑, FAK↓, STAT3↓, NF-kB↓,
128- CUR,  RES,    Evaluation of biophysical as well as biochemical potential of curcumin and resveratrol during prostate cancer
- in-vivo, Pca, NA
lipid-P↓, chemoPv↑, GSH↑, SOD↑, GSTs↑, glucose↓,
133- CUR,    Curcumin inhibits prostate cancer by targeting PGK1 in the FOXD3/miR-143 axis
- in-vitro, Pca, DU145 - in-vitro, Pca, PC3
miR-143↑, PDK1↓, FOXD3↑, TumCP↓, TumCMig↓, *Inflam↓, *antiOx↑, *chemoPv↑, RadioS↑, ChemoSen↑,
11- CUR,    Curcumin inhibits hypoxia-induced epithelial‑mesenchymal transition in pancreatic cancer cells via suppression of the hedgehog signaling pathway
- in-vitro, PC, PANC1
HH↓, Shh↓, Smo↓, Gli1↓, N-cadherin↓, E-cadherin↑, Vim↓, TumCP↓, TumCMig↓, TumCI↓, EMT↓, chemoPv↑,
165- CUR,    Curcumin interrupts the interaction between the androgen receptor and Wnt/β-catenin signaling pathway in LNCaP prostate cancer cells
- in-vitro, Pca, LNCaP
AR↓, β-catenin/ZEB1↓, p‑Akt↓, GSK‐3β↓, p‑β-catenin/ZEB1↑, cycD1/CCND1↓, cMyc↓, chemoPv↑, TumCP↓,
6671- Deg,    A Novel Derivative of the Natural Agent Deguelin for Cancer Chemoprevention and Therapy
- in-vitro, Nor, BEAS-2B - in-vitro, Lung, H1299 - in-vitro, Lung, H460
HSP90↓, toxicity↝, eff↑, chemoPv↑, p53 Wildtype↓, CDK4↓, MAPK↓, Hif1a↓, selectivity↑, compI↓, TumCP↓, BioAv↑,
6701- DFC,    Intracellular pH and calcium signaling as molecular targets of diclofenac-induced apoptosis against colon cancer
- in-vivo, Colon, NA
COX2↓, Inflam↓, chemoPv↑, Apoptosis↑, pH↓, ROS↑, Ca+2↑, MMP↓, APAF1↑,
6289- DL,    D-Limonene modulates inflammation, oxidative stress and Ras-ERK pathway to inhibit murine skin tumorigenesis
- in-vivo, Var, NA
COX2↓, *GSH↑, *GPx↑, *Catalase↑, Bcl-2↓, BAX↑, *chemoPv↑, *Inflam↓, *ROS↓, *RAS↓,
6266- DL,    Human breast tissue disposition and bioactivity of limonene in women with early-stage breast cancer
- Trial, BC, NA
chemoPv↑, cycD1/CCND1↓, IGF-1↑, TumCCA↑, TumCP↓,
6284- DL,    Chemoprevention and therapy of cancer by d-limonene
- in-vivo, Var, NA
chemoPv↑, other↑,
6279- DL,    Human breast tissue disposition and bioactivity of limonene in women with early stage breast cancer
- Trial, BC, NA
chemoPv↑, cycD1/CCND1↓,
6317- DRE,    The efficacy of dandelion root extract in inducing apoptosis in drug-resistant human melanoma cells
- in-vitro, Melanoma, A375
Apoptosis↑, selectivity↑, Casp8↑, mt-ROS↑, eff↑, *toxicity↓, Diff↑, TumCP↓, chemoPv↑, *ROS↓, *NO↓, *COX2↓, *RNS↓, TumCI↓, MMP2↓, MMP9↓, p‑Src↓, p‑FAK↓,
24- EGCG,  GEN,  QC,    Targeting CWR22Rv1 prostate cancer cell proliferation and gene expression by combinations of the phytochemicals EGCG, genistein and quercetin
- in-vitro, Pca, 22Rv1
NQO1↑, P53↑, NQO2↑, chemoPv↑, TumCP↓, AR↓,
6381- Eug,    Biological Properties and Prospects for the Application of Eugenol—A Review
- Review, Var, NA
*eff↑, *BioAv↝, *BioAv↝, *BioAv↑, *antiOx↑, *AntiAg↑, *Inflam↓, *AntiBio↑, *MAOA↓, *neuroP↑, *ROS↓, *RNS↓, *eff↑, NF-kB↓, PGE2↓, COX2↓, TumCCA↑, Apoptosis↑, TumCMig↓, TumCI↓, tumCV↓, PI3K↓, Akt↓, MMPs↓, ChemoSen↑, ALDH↓, *Pain↓, *VGSC↓, *IL1β↓, *IL6↓, *TNF-α↓, *iNOS↓, *5LO↓, *chemoPv↑,
6387- Eug,    Anticancer and antibacterial effects of a clove bud essential oil-based nanoscale emulsion system
- in-vitro, Thyroid, NA - in-vitro, Nor, HEK293
chemoPv↑, TumCP↓, selectivity↑,
2854- FIS,    New Perspectives for Fisetin
- Review, Var, NA - Review, Stroke, NA
Inflam↓, ChemoSen↑, chemoPv↑, eff↑, memory↑, neuroP↑, *Dose↑, BioAv↓, BBB↑,
2998- GEN,    Cellular and Molecular Mechanisms Modulated by Genistein in Cancer
- Review, Var, NA
Hif1a↓, VEGF↓, PDGF↓, uPA↓, MMP2↓, MMP9↓, chemoPv↑, TumCI↓, TumMeta↓, NF-kB↓, AP-1↓, IKKα↓, PI3K↓, Akt↓, EMT↓, CSCs↓,
2438- Gra,    Emerging therapeutic potential of graviola and its constituents in cancers
- Review, Var, NA
Hif1a↓, GLUT1↓, GLUT4↓, HK2↓, LDHA↓, MUC4↓, TumCCA↑, MMP↓, NF-kB↓, ROS↓, Bax:Bcl2↑, ER(estro)↓, cycD1/CCND1↓, chemoPv↑, hepatoP↑,
2883- HNK,    Honokiol targets mitochondria to halt cancer progression and metastasis
- Review, Var, NA
ChemoSen↑, BBB↓, Ca+2↑, Cyt‑c↑, Casp3↑, chemoPv↑, OCR↓, mitResp↓, Apoptosis↑, RadioS↑, NF-kB↓, Akt↓, TNF-α↓, PGE2↓, VEGF↓, NO↝, COX2↓, RAS↓, EMT↓, Snail↓, N-cadherin↓, β-catenin/ZEB1↓, E-cadherin↑, ER Stress↑, p‑STAT3↓, EGFR↓, mTOR↓, mt-ROS↑, PI3K↓, Wnt↓,
5116- JG,    Juglone, a naphthoquinone from walnut, exerts cytotoxic and genotoxic effects against cultured melanoma tumor cells
- in-vitro, Melanoma, B16-BL6
GSH↓, ROS↑, chemoPv↑,
6538- MeSal,  ASA,    Salicylate induces AMPK and inhibits c-MYC to activate a NRF2/ARE/miR-34a/b/c cascade resulting in suppression of colorectal cancer metastasis
- in-vitro, CRC, NA
chemoPv↑, AMPK↑, NRF2↑, miR-34a↑, cMyc↓, tumCV↓, Apoptosis↑, TumCI↓, TumCMig↓, MET↑,
6492- Nimb,    Review on Molecular and Chemopreventive Potential of Nimbolide in Cancer
- Review, NA, NA
Apoptosis↑, TumCCA↑, TumCP↓, TumCI↓, angioG↓, TumMeta↓, PTEN↑, NF-kB↓, Wnt↓, β-catenin/ZEB1↓, IKKα↓, CXCR2↓, CXCR4↓, Bcl-2↓, COX2↓, MMP9↓, VEGF↓, TIMP2↑, chemoPv↑, ROS↑, DR4↑, P53↑, BAX↑, Casp3↑, Casp8↑, Casp9↑, cl‑PARP↑, Mcl-1↓, XIAP↓, survivin↓, FasL↑, FADD↑, EGFR↓, MMPs↓,
6490- Nimb,    Nimbolide, a neem limonoid inhibits cytoprotective autophagy to activate apoptosis via modulation of the PI3K/Akt/GSK-3β signalling pathway in oral cancer
- in-vitro, Oral, SCC4
PI3K↓, Akt↓, GSK‐3β↑, MMP↓, Apoptosis↑, Bax:Bcl2↑, Cyt‑c↑, cl‑Casp3↑, cl‑Casp9↑, TumAuto↑, Beclin-1↓, p62↑, PI3K↓, chemoPv↑,
6487- Nimb,    Anticancer properties of nimbolide and pharmacokinetic considerations to accelerate its development
- Review, Var, NA
TumCP↓, Apoptosis↓, TumMeta↑, angioG↓, *antiOx↑, *eff↑, Apoptosis↑, MOMP↑, CDK1↓, TumCCA↑, MAPK↓, JAK2↓, STAT3↓, PI3K↓, Akt↓, TumCP↓, *NRF2↑, NF-kB↓, GSK‐3β↑, Wnt↓, β-catenin/ZEB1↓, chemoPv↑, Bcl-xL↓, Bcl-2↓, survivin↓, Cyt‑c↑, BAX↑, BID↑, cl‑Casp↑, P53↑, DR5↑, DR4↑, ROS↑, lipid-P↑, MDA↑, MMP2↓, MMP9↓, uPA↓, ICAM-1↓, CXCR4↓, CXCR2↓, angioG↓, BBB↑,
4970- Nimb,    Insights into Nimbolide molecular crosstalk and its anticancer properties
- Review, Var, NA
chemoPv↑, Apoptosis↑, TumCP↓, TumCD↑, TumMeta↓, angioG↓,
4628- OLE,    Effects of oleuropein on tumor cell growth and bone remodelling: Potential clinical implications for the prevention and treatment of malignant bone diseases
- in-vitro, Var, NA
chemoPv↑, TumCP↓, angioG↓, TumCI↓, TumMeta↓,
4947- PEITC,    Phenethyl Isothiocyanate (PEITC) Inhibits the Growth of Human Oral Squamous Carcinoma HSC-3 Cells through G0/G1   Phase Arrest and Mitochondria-Mediated Apoptotic Cell Death
- in-vitro, Oral, HSC3
AntiCan↑, chemoPv↑, TumCG↓, Apoptosis↑, TumCCA↑, P53↑, P21↑, BAX↑, BID↑, Bcl-2↓, MMP↓, Cyt‑c↑, AIF↑, ROS↑, Ca+2↑,
4964- PEITC,    Irreversible Inhibition of Glutathione S-Transferase by Phenethyl Isothiocyanate (PEITC), a Dietary Cancer Chemopreventive Phytochemical
- in-vitro, Var, NA
GSH↓, GSTA1↓, chemoPv↑,
4931- PEITC,    Phenethyl isothiocyanate (PEITC) suppresses prostate cancer cell invasion epigenetically through regulating microRNA-194
- in-vitro, Pca, LNCaP - in-vitro, Pca, PC3
Risk↓, miR-194↑, TumCI↓, MMP2↓, MMP9↓, BMP2↓, *chemoPv↑,
4934- PEITC,    Differential induction of apoptosis in human breast cancer cell lines by phenethyl isothiocyanate, a glutathione depleting agent
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231
GSH↓, ROS↑, chemoPv↑, Apoptosis↑, Casp9↑, Casp3↑, eff↓, TumCG↓, TumCCA↑, BAX↑, Nrf1↑, GSH↓, GSSG↓, GSH/GSSG↓,
4937- PEITC,    PEITC: Functional Compound for Primary and Tertiary Chemoprevention of Cancer
chemoPv↑, tumCV↓, GSH↓, ROS↑, *toxicity↝,
4942- PEITC,    Phenethyl Isothiocyanate (PEITC) Inhibits the Growth of Human Oral Squamous Carcinoma HSC-3 Cells through G(0)/G(1) Phase Arrest and Mitochondria-Mediated Apoptotic Cell Death
- in-vitro, Oral, HSC3
chemoPv↑, TumCG↓, TumCCA↑, Apoptosis↑, BAX↑, BID↑, Bcl-2↓, MMP↓, Cyt‑c↑, AIF↑, ROS↑, Ca+2↑,
5072- PEITC,    Inhibition and Inactivation of Human Cytochrome P450 Isoforms by Phenethyl Isothiocyanate
- in-vitro, Nor, NA
*CYP2E1↓, *chemoPv↑,
4969- PSO,    The Coumarin Psoralidin Enhances Anticancer Effect of Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL)
- in-vitro, Cerv, HeLa
AntiCan↑, chemoPv↑, TRAIL↑, selectivity↑, toxicity↓, MMP↓, Apoptosis↑,
44- QC,    Preclinical Colorectal Cancer Chemopreventive Efficacy and p53-Modulating Activity of 3′,4′,5′-Trimethoxyflavonol, a Quercetin Analog
- in-vivo, CRC, HCT116
P53↑, chemoPv↑, TumVol↓, TumCP↓, Apoptosis↑,
95- QC,    Quercetin, a natural dietary flavonoid, acts as a chemopreventive agent
- in-vitro, Pca, PC3
p‑ERK↓, p‑STAT3↓, p‑Akt↓, N-cadherin↓, Vim↓, cycD1/CCND1↓, Snail↓, Slug↓, Twist↓, PCNA↓, EGFR↓, chemoPv↑,
82- QC,  ATG,    Arctigenin in combination with quercetin synergistically enhances the anti-proliferative effect in prostate cancer cells
- in-vitro, Pca, LNCaP
AR↓, PI3K/Akt↓, miR-21↓, STAT3↓, BAD↓, PRAS40↓, GSK‐3β↓, PSA↓, NKX3.1↑, Bax:Bcl2↑, miR-19b↓, miR-148a↓, AMPKα↓, TumCP↓, chemoPv↑, TumCMig↓,
81- QC,  EGCG,    Enhanced inhibition of prostate cancer xenograft tumor growth by combining quercetin and green tea
- in-vivo, Pca, NA
COMT↓, MRP1/ABCC1↓, Ki-67↓, Bax:Bcl2↑, AR↓, Akt↓, p‑ERK↓, COMT↓, eff↑, chemoPv↑, BioAv↑,
100- QC,    Inhibition of Prostate Cancer Cell Colony Formation by the Flavonoid Quercetin Correlates with Modulation of Specific Regulatory Genes
- in-vitro, Pca, PC3 - in-vitro, Pca, DU145 - in-vitro, Pca, LNCaP
cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4/6↓, E2Fs↓, PCNA↓, cDC2↓, PTEN↑, MSH2↑, P21↑, EP300↑, BRCA1↑, NF2↑, TSC1↑, TGFβR1↑, P53↑, RB1↑, AKT1↓, cMyc↓, CDC7↓, cycF↓, CDC16↓, CUL4B↑, CBP↑, TSC2↑, HER2/EBBR2↓, BCR↓, TumCCA↑, chemoPv↑,

Showing Research Papers: 51 to 100 of 125
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 125

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

compI↓, 1,   GSH↓, 6,   GSH↑, 2,   GSH/GSSG↓, 1,   GSR↑, 1,   GSSG↓, 1,   GSTA1↓, 1,   GSTs↑, 2,   HO-1↑, 1,   lipid-P↓, 1,   lipid-P↑, 1,   MDA↑, 1,   NQO1↑, 1,   Nrf1↑, 2,   NRF2↓, 1,   NRF2↑, 1,   ROS↓, 1,   ROS↑, 11,   mt-ROS↑, 2,   SOD↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

AIF↑, 3,   ATP↓, 1,   BCR↓, 1,   CDC16↓, 1,   mitResp↓, 1,   MMP↓, 6,   MPT↑, 1,   OCR↓, 1,   XIAP↓, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AKT1↓, 1,   AMPK↑, 1,   cMyc↓, 3,   glucose↓, 1,   HK2↓, 1,   LDHA↓, 1,   PDK1↓, 1,   PI3K/Akt↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 8,   p‑Akt↓, 2,   APAF1↑, 1,   Apoptosis↓, 1,   Apoptosis↑, 20,   BAD↓, 1,   BAX↑, 8,   Bax:Bcl2↑, 5,   Bcl-2↓, 8,   Bcl-xL↓, 1,   BID↑, 3,   BMP2↓, 1,   cl‑Casp↑, 1,   Casp3↑, 6,   cl‑Casp3↑, 1,   Casp7↑, 1,   Casp8↑, 3,   Casp9↑, 4,   cl‑Casp9↑, 1,   CBP↑, 1,   Cyt‑c↑, 6,   DR4↑, 2,   DR5↑, 1,   FADD↑, 1,   FasL↑, 1,   hTERT/TERT↓, 1,   JNK↑, 1,   MAPK↓, 2,   Mcl-1↓, 3,   Mcl-1↑, 1,   MOMP↑, 1,   p27↑, 1,   Pyro↑, 1,   survivin↓, 3,   TRAIL↑, 1,   TumCD↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

AMPKα↓, 1,   CDC7↓, 1,   FOXD3↑, 1,   HER2/EBBR2↓, 1,   TSC2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

miR-143↑, 1,   miR-21↓, 2,   miR-27a-3p↓, 1,   other↑, 1,   tumCV↓, 3,  

Protein Folding & ER Stress(tgid=8) ⓘ

ER Stress↑, 1,   HSP90↓, 1,   NQO2↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1↓, 1,   p62↑, 1,   TumAuto↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

BRCA1↑, 1,   CUL4B↑, 1,   NKX3.1↑, 1,   P53↑, 6,   p53 Wildtype↓, 2,   cl‑PARP↑, 2,   PCNA↓, 2,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1,   CDK2↓, 1,   CDK4↓, 1,   cycD1/CCND1↓, 8,   cycE/CCNE↓, 2,   cycF↓, 1,   E2Fs↓, 1,   P21↑, 3,   RB1↑, 1,   TumCCA↑, 12,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 1,   cDC2↓, 1,   CSCs↓, 1,   Diff↑, 2,   EMT↓, 4,   EP300↑, 1,   ERK↓, 2,   p‑ERK↓, 2,   Gli1↓, 1,   GSK‐3β↓, 2,   GSK‐3β↑, 2,   HH↓, 1,   IGF-1↑, 1,   miR-194↑, 1,   miR-34a↑, 2,   mTOR↓, 1,   mTORC1↓, 1,   NF2↑, 1,   PI3K↓, 6,   PTEN↑, 2,   RAS↓, 1,   Shh↓, 1,   Smo↓, 1,   p‑Src↓, 1,   STAT3↓, 3,   p‑STAT3↓, 2,   TOP2↓, 1,   TumCG↓, 6,   Wnt↓, 3,  

Migration(tgid=13) ⓘ

AP-1↓, 1,   Ca+2↑, 4,   CDK4/6↓, 1,   E-cadherin↑, 3,   FAK↓, 2,   p‑FAK↓, 1,   Ki-67↓, 1,   MET↑, 1,   miR-148a↓, 1,   miR-19b↓, 1,   miR-200b↑, 1,   MMP2↓, 4,   MMP9↓, 6,   MMPs↓, 3,   MSH2↑, 1,   MUC4↓, 1,   N-cadherin↓, 4,   PDGF↓, 2,   Slug↓, 1,   Snail↓, 2,   TIMP2↑, 1,   TSC1↑, 1,   TumCI↓, 8,   TumCMig↓, 5,   TumCP↓, 18,   TumMeta↓, 6,   TumMeta↑, 1,   Twist↓, 1,   uPA↓, 2,   Vim↓, 2,   β-catenin/ZEB1↓, 5,   p‑β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 9,   EGFR↓, 3,   Hif1a↓, 5,   NO↝, 1,   VEGF↓, 4,   VEGFR2↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 1,   BBB↑, 2,   GLUT1↓, 1,   GLUT4↓, 1,   P-gp↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2↓, 5,   CXCR2↓, 2,   CXCR4↓, 2,   ICAM-1↓, 1,   IKKα↓, 2,   IL1β↓, 1,   Inflam↓, 3,   JAK2↓, 1,   NF-kB↓, 8,   PGE2↓, 2,   PSA↓, 1,   TLR4↝, 1,   TNF-α↓, 2,  

Cellular Microenvironment(tgid=17) ⓘ

pH↓, 1,  

Protein Aggregation(tgid=19) ⓘ

NLRP3↑, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 4,   COMT↓, 2,   ER(estro)↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 2,   BioAv↑, 2,   ChemoSen↑, 8,   ChemoSen∅, 1,   Dose↝, 1,   eff↓, 1,   eff↑, 4,   Half-Life↝, 1,   MRP1/ABCC1↓, 1,   P450↓, 1,   RadioS↑, 4,   selectivity↑, 5,  

Clinical Biomarkers(tgid=22) ⓘ

AR↓, 4,   BRCA1↑, 1,   EGFR↓, 3,   HER2/EBBR2↓, 1,   hTERT/TERT↓, 1,   Ki-67↓, 1,   PSA↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 5,   AntiTum↑, 2,   chemoPv↑, 42,   hepatoP↑, 1,   memory↑, 1,   neuroP↑, 1,   PRAS40↓, 1,   Risk↓, 1,   TGFβR1↑, 1,   toxicity↓, 1,   toxicity↝, 1,   TumVol↓, 1,  
Total Targets: 227

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

AntiBio↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 7,   Catalase↑, 1,   CYP2E1↓, 1,   GPx↑, 1,   GSH↑, 1,   NRF2↑, 1,   RNS↓, 2,   ROS↓, 6,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

lipidLev↓, 1,   PPARα↑, 1,  

Cell Death(tgid=5) ⓘ

iNOS↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 1,   PCNA↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

RAS↓, 1,   VGSC↓, 1,  

Migration(tgid=13) ⓘ

5LO↓, 1,   AntiAg↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

NO↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2↓, 2,   IL1β↓, 1,   IL6↓, 1,   Imm↑, 1,   Inflam↓, 7,   NF-kB↓, 1,   TNF-α↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

MAOA↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   BioAv↑, 1,   BioAv↝, 2,   Dose↑, 1,   eff↑, 3,  

Clinical Biomarkers(tgid=22) ⓘ

IL6↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiCan↓, 1,   AntiDiabetic↑, 1,   cardioP⇅, 1,   chemoPv↑, 8,   hepatoP↑, 3,   memory↑, 1,   neuroP↑, 3,   OS↑, 1,   Pain↓, 1,   RenoP↑, 1,   toxicity↓, 1,   toxicity↝, 1,   Wound Healing↑, 1,  
Total Targets: 47

Scientific Paper Hit Count for: chemoPv, ChemoPreventive
8 Curcumin
7 Phenethyl isothiocyanate
6 Capsaicin
6 Chrysin
6 Resveratrol
6 Quercetin
5 Chemotherapy
5 Sulforaphane (mainly Broccoli)
4 Apigenin (mainly Parsley)
4 D-limonene
4 Nimbolide
4 Thymoquinone
3 EGCG (Epigallocatechin Gallate)
3 Betulinic acid
3 Chlorophyllin
3 Chocolate
3 α-Santalol/Sandalwood oil
2 Astaxanthin
2 Arctigenin
2 Biochanin A
2 Carvacrol
2 Celecoxib
2 Cucurbitacin
2 Genistein (soy isoflavone)
2 Eugenol
1 Silver-NanoParticles
1 probiotics
1 Allicin (mainly Garlic)
1 DTS(dibenzyl trisulphide) from Anamu
1 Anethole/trans-Anethole
1 Luteolin
1 Ashwagandha(Withaferin A)
1 Berberine
1 Beta-Caryophyllene
1 Boron
1 Boswellia (frankincense)
1 Bruteridin(bergamot juice)
1 Butyrate
1 Caffeic acid
1 Carnosic acid
1 Calcium
1 Caffeic Acid Phenethyl Ester (CAPE)
1 Celastrol
1 Chlorogenic acid
1 Cinnamon
1 Coenzyme Q10
1 Carica papaya leaf extract
1 Calorie Restriction Mimetics
1 Crocetin
1 Carvone
1 methylseleninic acid
1 Deguelin
1 Diclofenac
1 Dandelion Root
1 Fisetin
1 Graviola
1 Honokiol
1 Juglone
1 Methyl salicylate / Sweet Birch oil
1 Aspirin
1 Oleuropein
1 Psoralidin
1 Selenium
1 Selenium NanoParticles
1 Silymarin (Milk Thistle) silibinin
1 Shikonin
1 Selenite (Sodium)
1 Sutherlandioside D
1 Ursolic acid
1 Vitamin C (Ascorbic Acid)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1417  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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