chemoPv Cancer Research Results

chemoPv, ChemoPreventive: Click to Expand ⟱
Source:
Type:
Chemopreventive: An agent that lowers the probability of cancer development or delays progression from premalignant states.
Mechanisms
-Reduce DNA damage / mutagenesis
-Enhance detoxification or repair
-Modulate hormones or inflammation
-Promote differentiation or apoptosis of abnormal cells


Scientific Papers found: Click to Expand⟱
2783- CHr,    Apoptotic Effects of Chrysin in Human Cancer Cell Lines
- Review, Var, NA
TumCP↓, Apoptosis↑, Casp↑, PCNA↓, p38↑, NF-kB↑, DNAdam↑, XIAP↓, Cyt‑c↑, Casp3↑, Akt↓, SCF↓, hTERT/TERT↓, COX2/PTGS2↓, *Inflam↓, *antiOx↑, *chemoPv↑, AR-V7?, CYP19?,
2786- CHr,    Chemopreventive and therapeutic potential of chrysin in cancer: mechanistic perspectives
- Review, Var, NA
Apoptosis↑, TumCCA↑, angioG↓, TumCI↓, TumMeta↑, *toxicity↓, selectivity↑, chemoPv↑, *GSTs↑, *NADPH↑, *GSH↑, HDAC8↓, Hif1a↓, *ROS↓, *NF-kB↓, SCF↓, cl‑PARP↑, survivin↓, XIAP↓, Casp3↑, Casp9↑, GSH↓, ChemoSen↑, Fenton↑, P21↑, P53↑, cycD1/CCND1↓, CDK2↓, STAT3↓, VEGF↓, Akt↓, NRF2↓,
2788- CHr,    Chrysin: Sources, beneficial pharmacological activities, and molecular mechanism of action
- Review, Var, NA
*neuroP↑, *Inflam↓, *ROS↓, NF-kB↓, *PCNA↓, *COX2/PTGS2↓, ChemoSen↑, Hif1a↓, angioG↓, *chemoPv↑, PDGF↓, *memory↑, *RenoP↑, *PPARα↑, *lipidLev↓, *hepatoP↑, *cardioP⇅, *BioAv↓,
6144- Cin,    The Cinnamon-Derived Dietary Factor Cinnamic Aldehyde Activates the Nrf2-Dependent Antioxidant Response in Human Epithelial Colon Cells
- in-vitro, Colon, HCT116
Nrf1↑, HO-1↑, chemoPv↑,
4762- CoQ10,    The role of coenzyme Q10 as a preventive and therapeutic agent for the treatment of cancers
- Review, Var, NA
*AntiCan↓, *ROS↓, chemoPv↑, TumCCA↑, Apoptosis↑, TumCP↓, angioG↓, MMPs↓, ChemoSen∅,
6373- CPLE,    Anticancer Activity of Phytochemicals of the Papaya Plant Assessed: A Narrative Review
- Review, Var, NA
chemoPv↑, TumCP↓, angioG↓, TumMeta↓, ROS↑, Dose↝,
5801- CRMs,  Chemo,    Caloric Restriction Enhances Chemotherapy Efficacy and Reshapes Stress Responses in Sarcoma
- in-vivo, sarcoma, NA
TumCG↓, *hepatoP↑, *ROS↓, *OS↑, ChemoSen↑, chemoPv↑, selectivity↑, *DNAdam↓,
6294- Cro,    Crocetin and Crocin from Saffron in Cancer Chemotherapy and Chemoprevention
- Review, Var, NA
*chemoPv↑, *antiOx↑, Apoptosis↑, TumCP↓, Diff↑, TumCCA↑, TumCG↓, TOP2↓, hTERT/TERT↓, Inflam↓, IL1β↓, TNF-α↓, Casp8↑, BAX↑, Cyt‑c↑, ChemoSen↑, RadioS↑, Apoptosis↑, cycD1/CCND1↓, P21↑, p27/CDKN1B↑, Bcl-2↓, Bax:Bcl2↑, Casp9↑, EMT↓, E-cadherin↑, β-catenin/ZEB1↓, N-cadherin↓,
6527- CRV,    Preventive effect of D-carvone during DMBA induced mouse skin tumorigenesis by modulating xenobiotic metabolism and induction of apoptotic events
- in-vivo, Melanoma, NA
AntiTum↑, P450↓, GSR↑, GSTs↑, GSH↑, BAX↑, Casp3↑, Casp9↑, Bcl-2↓, p53 Wildtype↓, chemoPv↑, Apoptosis↑,
7411- CS,    Long Term Exposure to Polyphenols of Artichoke (Cynara scolymus L.) Exerts Induction of Senescence Driven Growth Arrest in the MDA-MB231 Human Breast Cancer Cell Line
- in-vitro, BC, MDA-MB-231 - in-vitro, CRC, HCT116
AntiCan↑, chemoPv↑, Apoptosis↑, TumCI↓, Casp↑, p16↑, P21↑, TumCCA↑, ROS↓, eff↓, TumCD↑, TumCG↓, cellSen↑, *ROS↓,
6195- Cuc,    Cucurbitacins as Potent Chemo-Preventive Agents: Mechanistic Insight and Recent Trends
- Review, Var, NA
TumCG↓, Apoptosis↑, TumCCA↑, TumMeta↓, angioG↓, chemoPv↑, BioAv↓, Half-Life↝, cycD1/CCND1↓, cycE/CCNE↓, Casp3↑, cl‑PARP↑, JNK↑, Akt↓, ERK↓, survivin↓, XIAP↓, Bcl-2↓, Mcl-1↓, ROS↑, NRF2↓, FAK↓, MMP9↓, VEGF↓, VEGFR2/KDR/Flk1↓, *NF-kB↓, TLR4↝, NLRP3↑, Pyro↑, GSH↓,
6202- Cuc,    Cucurbitacins as potential anticancer agents: new insights on molecular mechanisms
- Review, Var, NA
*Inflam↓, *antiOx↑, *hepatoP↑, AntiTum↑, AntiCan↑, *chemoPv↑, *AntiDiabetic↑, *Imm↑, Hif1a↓, P-gp/ABCB1↓, mTORC1↓, ERK↓, Akt↓, Casp3↑, Casp7↑, ATP↓, RadioS↑, ChemoSen↑,
161- CUR,  MeSA,    Enhanced apoptotic effects by the combination of curcumin and methylseleninic acid: potential role of Mcl-1 and FAK
- in-vitro, BC, MDA-MB-231 - in-vitro, Pca, DU145
Mcl-1↑, Mcl-1↓, MPT↑, AIF↑, chemoPv↑, Apoptosis↑, ROS↑, FAK↓, STAT3↓, NF-kB↓,
128- CUR,  RES,    Evaluation of biophysical as well as biochemical potential of curcumin and resveratrol during prostate cancer
- in-vivo, Pca, NA
lipid-P↓, chemoPv↑, GSH↑, SOD↑, GSTs↑, glucose↓,
133- CUR,    Curcumin inhibits prostate cancer by targeting PGK1 in the FOXD3/miR-143 axis
- in-vitro, Pca, DU145 - in-vitro, Pca, PC3
miR-143↑, PDK1 / PDPK1↓, FOXD3↑, TumCP↓, TumCMig↓, *Inflam↓, *antiOx↑, *chemoPv↑, RadioS↑, ChemoSen↑,
11- CUR,    Curcumin inhibits hypoxia-induced epithelial‑mesenchymal transition in pancreatic cancer cells via suppression of the hedgehog signaling pathway
- in-vitro, PC, PANC1
HH↓, Shh↓, Smo↓, Gli1↓, N-cadherin↓, E-cadherin↑, Vim↓, TumCP↓, TumCMig↓, TumCI↓, EMT↓, chemoPv↑,
165- CUR,    Curcumin interrupts the interaction between the androgen receptor and Wnt/β-catenin signaling pathway in LNCaP prostate cancer cells
- in-vitro, Pca, LNCaP
AR↓, β-catenin/ZEB1↓, p‑Akt↓, GSK‐3β↓, p‑β-catenin/ZEB1↑, cycD1/CCND1↓, cMyc↓, chemoPv↑, TumCP↓,
4654- CUR,    Stem Cell Therapy: Curcumin Does the Trick
- Review, Var, NA
*antiOx↑, *Inflam↓, AntiCan↑, chemoPv↑, *AntiAge↑, *neuroP↑, *Wound Healing↑,
4708- CUR,    Molecular mechanisms underlying curcumin-mediated microRNA regulation in carcinogenesis; Focused on gastrointestinal cancers
- Review, GC, NA
chemoPv↑, AntiCan↑, *antiOx↑, *Inflam↓, miR-21↓, miR-34a↑, miR-200b↑, miR-27a-3p↓,
6671- Deg,    A Novel Derivative of the Natural Agent Deguelin for Cancer Chemoprevention and Therapy
- in-vitro, Nor, BEAS-2B - in-vitro, Lung, H1299 - in-vitro, Lung, H460
HSP90↓, toxicity↝, eff↑, chemoPv↑, p53 Wildtype↓, CDK4↓, MAPK↓, Hif1a↓, selectivity↑, compI↓, TumCP↓, BioAv↑,
6701- DFC,    Intracellular pH and calcium signaling as molecular targets of diclofenac-induced apoptosis against colon cancer
- in-vivo, Colon, NA
COX2/PTGS2↓, Inflam↓, chemoPv↑, Apoptosis↑, pH↓, ROS↑, Ca+2↑, MMP↓, APAF1↑,
8829- DIM,    Anti-androgenic activity of absorption-enhanced 3, 3’-diindolylmethane in prostatectomy patients
- Human, Pca, NA
Risk↓, BioAv↑, Dose↝, Dose↝, AR↝, PSA↓, toxicity↓, chemoPv↑,
8831- DIM,    3,3′-Diindolylmethane Exhibits Significant Metabolism after Oral Dosing in Humans
- Human, Nor, NA
*chemoPv↑, *Dose↝, *Half-Life?, *BioAv↝, NA↑, CYP1A2↑, 2/16-OHE1↑, AR↝, BioAv↑,
8849- DIM,  I3C,    Indoles Derived From Glucobrassicin: Cancer Chemoprevention by Indole-3-Carbinol and 3,3'-Diindolylmethane
- Review, Var, NA
DNMTs↓, HDAC1↓, HDAC2↓, HDAC3↓, HDAC8↓, chemoPv↑, AntiCan↑, CYP3A4↓, Dose↝, GutMicro↑, Synergy↑,
8841- DIM,    3,3'-Diindolylmethane Suppresses the Growth of Hepatocellular Carcinoma by Regulating Its Invasion, Migration, and ER Stress-Mediated Mitochondrial Apoptosis
- in-vitro, Liver, Hep3B - in-vitro, Liver, HUH7
TumCG↓, TumCP↓, TumCMig↓, TumCI↓, Casp↑, EMT↓, UPR↓, Ca+2↑, ROS↑, MMP↓, ER Stress↑, CHOP/DDIT3↑, GRP78/BiP↑, IRE1↑, PERK↑, PDI↑, MMP2↓, MMP9↓, N-cadherin↓, Vim↓, Slug↓, Snail↓, chemoPv↑,
6289- DL,    D-Limonene modulates inflammation, oxidative stress and Ras-ERK pathway to inhibit murine skin tumorigenesis
- in-vivo, Var, NA
COX2/PTGS2↓, *GSH↑, *GPx↑, *Catalase↑, Bcl-2↓, BAX↑, *chemoPv↑, *Inflam↓, *ROS↓, *RAS↓,
6266- DL,    Human breast tissue disposition and bioactivity of limonene in women with early-stage breast cancer
- Trial, BC, NA
chemoPv↑, cycD1/CCND1↓, IGF-1↑, TumCCA↑, TumCP↓,
6284- DL,    Chemoprevention and therapy of cancer by d-limonene
- in-vivo, Var, NA
chemoPv↑, other↑,
6279- DL,    Human breast tissue disposition and bioactivity of limonene in women with early stage breast cancer
- Trial, BC, NA
chemoPv↑, cycD1/CCND1↓,
6317- DRE,    The efficacy of dandelion root extract in inducing apoptosis in drug-resistant human melanoma cells
- in-vitro, Melanoma, A375
Apoptosis↑, selectivity↑, Casp8↑, mt-ROS↑, eff↑, *toxicity↓, Diff↑, TumCP↓, chemoPv↑, *ROS↓, *NO↓, *COX2/PTGS2↓, *RNS↓, TumCI↓, MMP2↓, MMP9↓, p‑Src↓, p‑FAK↓,
7193- EGb 761,  5-FU,    Ginkgo biloba extract 761 enhances 5-fluorouracil chemosensitivity in colorectal cancer cells through regulation of high mobility group-box 3 expression
- in-vitro, CRC, SW480 - in-vitro, CRC, SW-620
*antiOx↑, AntiCan↑, ChemoSen↑, selectivity↑, EMT↓, E-cadherin↑, Vim↓, HMGB1↓, other↝, chemoPv↑,
24- EGCG,  GEN,  QC,    Targeting CWR22Rv1 prostate cancer cell proliferation and gene expression by combinations of the phytochemicals EGCG, genistein and quercetin
- in-vitro, Pca, 22Rv1
NQO1↑, P53↑, NQO2↑, chemoPv↑, TumCP↓, AR↓,
6381- Eug,    Biological Properties and Prospects for the Application of Eugenol—A Review
- Review, Var, NA
*eff↑, *BioAv↝, *CompStab↝, *BioAv↑, *antiOx↑, *AntiAg↑, *Inflam↓, *AntiBio↑, *MAOA↓, *neuroP↑, *ROS↓, *RNS↓, *Synergy↑, NF-kB↓, PGE2↓, COX2/PTGS2↓, TumCCA↑, Apoptosis↑, TumCMig↓, TumCI↓, tumCV↓, PI3K↓, Akt↓, MMPs↓, ChemoSen↑, ALDH↓, *Pain↓, *VGSC↓, *IL1β↓, *IL6↓, *TNF-α↓, *iNOS↓, *5LO↓, *chemoPv↑, *antiAll↑,
6387- Eug,    Anticancer and antibacterial effects of a clove bud essential oil-based nanoscale emulsion system
- in-vitro, Thyroid, NA - in-vitro, Nor, HEK293
chemoPv↑, TumCP↓, selectivity↑,
6897- FIS,    Fisetin: A Dietary Antioxidant for Health Promotion
- Review, Nor, NA
*chemoPv↑, *neuroP↑, *antiOx↑, *GSH↑, *HO-1↑, *NRF2↑, angioG↓, TumCG↓, uPA↓, MMP1↓, tumCV↓, PTEN↑, PI3K↓, p‑Akt↓, AMPK↑, mTOR↓, EGFR↓, NF-kB↓, COX2/PTGS2↓, PGE2↓, Wnt↓, β-catenin/ZEB1↓, TCF↓, cycD1/CCND1↓, MMP7↓, RadioS↑, PSA↓, Securin↓, TumCCA↑, XIAP↓, *ERK↑, *p‑CREB↑, *memory↑, *GSH↑, *Inflam↓, *5LO↓,
6912- FIS,    Cancer chemopreventive role of fisetin: Regulation of cell signaling pathways in different cancers
- Review, Var, NA
TumMeta↓, chemoPv↑, VEGF↓, VEGFR1↓, EGFR↓, Necroptosis↑, Hippo↝,
6895- FIS,    Enhanced bioavailability and pharmacokinetics of a novel hybrid-hydrogel formulation of fisetin orally administered in healthy individuals: a randomised double-blinded comparative crossover study
- in-vivo, Nor, NA
*neuroP↑, *cardioP↑, *chemoPv↑, *AntiDiabetic↑, *Inflam↓, *ROS↓, *BioAv↓, *BioAv↑, *eff↑, *Half-Life↓,
2854- FIS,    New Perspectives for Fisetin
- Review, Var, NA - Review, Stroke, NA
Inflam↓, ChemoSen↑, chemoPv↑, Synergy↑, memory↑, neuroP↑, *Dose↑, BioAv↓, BBB↑,
6982- Form,    Formononetin: A Review of Its Anticancer Potentials and Mechanisms
- Review, Var, NA
AntiTum↑, Apoptosis↑, BAX↑, Bcl-2↓, Casp3↑, TumCCA↑, cycA1/CCNA1↓, CycB/CCNB1↓, cycD1/CCND1↓, TumCP↓, VEGF↓, FGF↓, MMP2↓, MMP9↓, Synergy↑, ChemoSen↑, chemoPv↑, p‑Akt↓, p‑STAT3↑, TumCMig↓, TumCI↓, TIMP1↑, TIMP2↑, PI3K↓, Akt↓, Dose↝, TumCG↓, TumW↓, TumVol↓, angioG↓, Casp3↑, Casp9↑, cl‑PARP↑, DNArepair↓, MMP↓, BAX↑, Bcl-2↓, DR5↑, ROS↑, eff↓, p‑ERK↓, PTEN↑, Hif1a↓, eff↑, Synergy↑, ChemoSen↑, HDAC↓, *BioAv↑, *Half-Life↝, *BioAv↝, *BioAv↑, *BioAv↑, *eff↑,
6969- Form,    Formononetin inhibits tumor growth by suppression of EGFR-Akt-Mcl-1 axis in non-small cell lung cancer
- vitro+vivo, NSCLC, HCC827 - in-vitro, NSCLC, A549 - in-vitro, Lung, H1299
EGFR↓, Akt↓, GSK‐3β↑, TumCG↓, ChemoSen↑, Mcl-1↓, RadioS↑, tumCV↓, selectivity↑, Dose↝, Cyt‑c↑, BAX↑, Apoptosis↑, Ki-67↓, toxicity↓, chemoPv↑,
7084- GAR,    A unique in vivo pharmacokinetic profile, in vitro metabolic stability and hepatic first-pass metabolism of garcinol, a promising novel anticancer phytoconstituent, by liquid chromatography–mass spectrometry
- in-vivo, Nor, NA
*BioAv↝, *Dose↝, *Inflam↓, *antiOx↑, *chemoPv↑, Wnt↓, β-catenin/ZEB1↓, ERK↓, PI3K↓, Akt↓, NF-kB↓, STAT3↓, TumCP↓, antiNeop↑, ChemoSen↑, chemoP↑,
2998- GEN,    Cellular and Molecular Mechanisms Modulated by Genistein in Cancer
- Review, Var, NA
Hif1a↓, VEGF↓, PDGF↓, uPA↓, MMP2↓, MMP9↓, chemoPv↑, TumCI↓, TumMeta↓, NF-kB↓, AP-1↓, IKKα↓, PI3K↓, Akt↓, EMT↓, CSCs↓,
7143- GI,  Chemo,    Effect of a Standardized Ginger Root Powder Regimen on Chemotherapy-Induced Nausea and Vomiting: A Multicenter, Double-Blind, Placebo-Controlled Randomized Trial
- Trial, Var, NA
Dose↝, chemoPv↑, Nausea↓, Vomit↓, mal↓, QoL↑,
2438- Gra,    Emerging therapeutic potential of graviola and its constituents in cancers
- Review, Var, NA
Hif1a↓, GLUT1↓, GLUT4↓, HK2↓, LDHA↓, MUC4↓, TumCCA↑, MMP↓, NF-kB↓, ROS↓, Bax:Bcl2↑, ER(estro)↓, cycD1/CCND1↓, chemoPv↑, hepatoP↑,
7327- GSE,    Dietary-feeding of grape seed extract prevents azoxymethane-induced colonic aberrant crypt foci formation in fischer 344 rats
- in-vivo, CRC, NA
chemoPv↑, TumCP↓, Apoptosis↑, cycD1/CCND1↓, COX2/PTGS2↓, iNOS↓, survivin↓, β-catenin/ZEB1↓, NF-kB↓, Risk↓,
7324- GSE,    A Pilot Study of a Grape Seed Procyanidin Extract for Lung Cancer Chemoprevention
- Trial, Lung, NA
BioAv↑, toxicity↝, Ki-67↓, miR-106b↓, chemoPv↑, Dose↝, miR-19b↓, PTEN↑, IGF-2R↑, p‑Akt↓, PGE2↓, PGI2↓, COX2/PTGS2↓, Apoptosis↑, TumCP↓, Inflam↓, cardioP↑,
7365- HibSad,    Insight into the molecular evidence supporting the remarkable chemotherapeutic potential of Hibiscus sabdariffa L
- Review, Var, NA
chemoPv↑, selectivity↑, TumCCA↑, Apoptosis↑, TumAuto↑, TumMeta↓, ATG5↑, Beclin-1/ATG6↑, LC3II↑, MMP2↓, MMP9↓, CD31/PECAM-1↓, VEGF↓, uPA↓, TIMP2↑, NF-kB↓, p38↑, P53↑, Casp3↑, Casp8↑, Casp9↑, Bcl-2↓, BAX↑, Cyt‑c↑, TNF-α↑, Fas↑, FasL↑, JNK↑, cJun↑, angioG↓, VEGFR2/KDR/Flk1↓, PCNA↓, CCN2/CTGF↓, RAGE↓,
7358- HibSad,    Chemopreventive properties and molecular mechanisms of the bioactive compounds in Hibiscus sabdariffa Linne
- Review, Var, NA
chemoPv↑, *ROS↓, *other↝, *hepatoP↑, *lipid-P↓, Apoptosis↑, *LDL↓, RAS↓, Akt↓, NF-kB↓, Rho↝, MMPs↓, *AntiDiabetic↑, *Catalase↑, *GSH↑,
2883- HNK,    Honokiol targets mitochondria to halt cancer progression and metastasis
- Review, Var, NA
ChemoSen↑, BBB↓, Ca+2↑, Cyt‑c↑, Casp3↑, chemoPv↑, OCR↓, mitResp↓, Apoptosis↑, RadioS↑, NF-kB↓, Akt↓, TNF-α↓, PGE2↓, VEGF↓, NO↝, COX2/PTGS2↓, RAS↓, EMT↓, Snail↓, N-cadherin↓, β-catenin/ZEB1↓, E-cadherin↑, ER Stress↑, p‑STAT3↓, EGFR↓, mTOR↓, mt-ROS↑, PI3K↓, Wnt↓,
7469- Hops,    CHEMOPREVENTIVE PROPERTIES OF SPENT HOPS (HUMULUS LUPULUS L.) EXTRACT AGAINST ANGIOGENESIS, INVASION AND MIGRATION OF COLORECTAL CANCER CELLS
- in-vitro, CRC, SW48 - in-vitro, CRC, HT29
angioG↓, TumCI↓, TumCMig↓, MMP2↓, MMP9↓, VEGF↓, Hif1a↓, chemoPv↑,

Showing Research Papers: 51 to 100 of 172
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 172

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↓, 1,   NA↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 6,   Catalase↓, 1,   Catalase↑, 2,   Fenton↑, 1,   GCLM↑, 1,   GPx↓, 1,   GSH↓, 8,   GSH↑, 3,   GSH/GSSG↓, 2,   GSR↑, 1,   GSSG↓, 1,   GSTs↑, 2,   H2O2↓, 1,   H2O2↑, 1,   HO-1↑, 2,   lipid-P?, 1,   lipid-P↓, 2,   lipid-P↑, 2,   MDA↑, 1,   NADH↓, 1,   NOX↓, 1,   NQO1↑, 4,   Nrf1↑, 2,   NRF2↓, 4,   NRF2↑, 4,   Prx↓, 2,   ox-PrxI↑, 1,   RNS↑, 1,   ROS↓, 7,   ROS↑, 42,   ROS⇅, 2,   mt-ROS↑, 3,   selenoP↑, 1,   SOD↓, 2,   SOD↑, 2,   SOD2↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Mets↑, 1,   Tf↓, 2,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

BCR↓, 1,   CDC16↓, 1,   CDC25↓, 1,   compI↓, 2,   ETC↓, 1,   mitResp↓, 2,   mitResp↑, 1,   mtDam↑, 4,   OCR↓, 1,   OXPHOS↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACLY↓, 1,   AMPK↑, 10,   ATP↓, 2,   FASN↓, 2,   glucose↓, 1,   Glycolysis↓, 1,   GSK‐3β↓, 2,   GSK‐3β↑, 4,   GSK‐3β↝, 1,   p‑GSK‐3β↓, 2,   HK2↓, 2,   lactateProd↓, 1,   LDHA↓, 1,   NADPH↑, 2,   PDK1 / PDPK1↓, 1,   PKM2↓, 1,   SCFAs↑, 1,   SIRT1↓, 2,   SIRT1↑, 2,   Warburg↓, 1,  

Cell Death(tgid=5) ⓘ

AIF↑, 3,   APAF1↑, 3,   Apoptosis↓, 1,   Apoptosis↑, 63,   BAD↓, 1,   Bak↑, 1,   BAX↑, 18,   Bax:Bcl2↑, 10,   Bcl-2↓, 20,   Bcl-xL↓, 3,   BID↑, 3,   cl‑BID↑, 1,   Casp↑, 5,   cl‑Casp↑, 1,   Casp12↑, 2,   Casp3↑, 30,   cl‑Casp3↑, 4,   Casp7↑, 1,   cl‑Casp7↑, 1,   Casp8↑, 9,   cl‑Casp8↑, 1,   Casp9↑, 17,   cl‑Casp9↑, 3,   cFLIP↓, 1,   Cyt‑c↑, 23,   Diablo↑, 1,   DR5↑, 5,   FADD↑, 3,   Fap1↓, 1,   Fas↑, 1,   FasL↑, 3,   IAP1↓, 1,   IAP2/BIRC3↑, 1,   cl‑IAP2/BIRC3↑, 1,   iNOS↓, 4,   Mcl-1↓, 6,   Mcl-1↑, 1,   MOMP↑, 1,   Necroptosis↑, 1,   necrosis↑, 1,   p38↑, 3,   p‑p38↓, 1,   PUMA↑, 1,   Pyro↑, 1,   survivin↓, 9,   TRAIL↑, 1,   TumCD↑, 4,   XIAP↓, 6,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 30,   Akt↑, 1,   p‑Akt↓, 7,   AKT1↓, 1,   AMPKα↓, 1,   CDC7↓, 1,   CK2↓, 3,   cMET↓, 1,   EGFR↓, 8,   ERK↓, 7,   p‑ERK↓, 5,   FOXD3↑, 1,   HER2/EBBR2↓, 3,   Hippo↑, 1,   Hippo↝, 1,   IGF-2R↑, 1,   IKKα↓, 3,   IκB↓, 1,   JAK↓, 1,   JAK1↓, 1,   JAK2↓, 3,   JNK↓, 1,   JNK↑, 7,   p‑JNK↓, 2,   MAPK↓, 6,   MAPK↑, 1,   mTOR↓, 12,   P70S6K↓, 1,   p‑PDGFR-BB↓, 1,   PI3K↓, 23,   PI3K/Akt↓, 2,   PRAS40↓, 1,   PTEN↑, 6,   RAS↓, 2,   Sp1/3/4↓, 4,   p‑Src↓, 1,   STAT↓, 1,   STAT3↓, 16,   p‑STAT3↓, 4,   p‑STAT3↑, 1,   TSC2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

CBP↑, 1,   cJun↓, 1,   cJun↑, 1,   cMyc↓, 4,   DNMT1↓, 2,   DNMT3A↓, 1,   DNMTs↓, 1,   FOXO3↓, 1,   FOXO3↑, 3,   HDAC↓, 7,   HDAC1↓, 2,   HDAC2↓, 1,   HDAC3↓, 2,   HDAC8↓, 2,   HOTAIR↓, 1,   miR-106b↓, 2,   miR-10a-5p↝, 1,   miR-143↑, 1,   miR-148a↓, 1,   miR-155↝, 1,   miR-194↑, 1,   miR-19b↓, 2,   miR-200b↑, 2,   miR-21↓, 3,   miR-27a-3p↓, 1,   miR-29b↓, 1,   miR-34a↑, 3,   miR-34a↝, 1,   MYCN↓, 1,   OCT4↓, 1,   other↓, 2,   other↑, 1,   other↝, 2,   SOX4↓, 1,   tumCV↓, 14,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,   CHOP/DDIT3↑, 3,   ER Stress↑, 10,   GRP78/BiP↑, 3,   HSP70/HSPA5↑, 1,   HSP90↓, 3,   HSP90↑, 1,   HSPs↓, 1,   IRE1↑, 2,   NQO2↑, 1,   PDI↑, 1,   PERK↑, 1,   UPR↓, 1,   XBP-1↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG3↑, 1,   ATG5↑, 5,   ATG7↑, 1,   Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 4,   LC3II↑, 4,   p62↑, 2,   TumAuto↑, 9,  

DNA Damage & Repair(tgid=10) ⓘ

BRCA1↑, 1,   CUL4B↑, 1,   DNAdam↑, 7,   DNArepair↓, 1,   hTERT/TERT↓, 2,   MSH2↑, 1,   NKX3.1↑, 1,   p16↑, 1,   P53↓, 1,   P53↑, 17,   p53 Wildtype↓, 2,   PARP↑, 1,   cl‑PARP↑, 14,   PCNA↓, 7,   Telomerase↓, 3,   TOP1↓, 2,   TOP2↓, 1,   TOP2↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 3,   CDK1↑, 1,   CDK2↓, 7,   CDK4↓, 8,   CDK4/6↓, 1,   CDK6↓, 5,   cellSen↑, 1,   Chk2↑, 1,   Cyc↓, 1,   cycA1/CCNA1↓, 1,   CycB/CCNB1↓, 3,   cycD1/CCND1↓, 18,   CycD3↓, 1,   cycE/CCNE↓, 5,   cycF↓, 1,   E2Fs↓, 1,   Ki-67↓, 5,   P21↓, 2,   P21↑, 10,   p27/CDKN1B↑, 4,   pRB↑, 1,   p‑pRB↓, 1,   RB1↑, 1,   p‑RB1↓, 1,   Securin↓, 1,   TumCCA↑, 38,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 1,   ALDH1A1↓, 1,   BMP2↓, 1,   CD133↓, 1,   CSCs↓, 6,   Diff↑, 2,   EP300↑, 1,   FGF↓, 1,   Gli↓, 1,   Gli1↓, 4,   HH↓, 3,   IGF-1↓, 4,   IGF-1↑, 1,   IGFBP1↑, 1,   IGFBP3↑, 1,   Ki-67↓, 5,   Let-7↑, 1,   mTORC1↓, 1,   NF2↑, 1,   NOTCH↓, 2,   NOTCH3↓, 1,   PTCH1↓, 2,   SCF↓, 2,   Shh↓, 3,   Smo↓, 2,   TumCG↓, 23,   TumCP↓, 35,   TumCP↑, 1,   Wnt↓, 11,   Wnt/(β-catenin)↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 1,   AP-1↓, 3,   Ca+2↓, 1,   Ca+2↑, 11,   i-Ca+2?, 1,   cal2↑, 1,   CCN2/CTGF↓, 1,   E-cadherin↑, 6,   EMT↓, 13,   FAK↓, 4,   p‑FAK↓, 2,   GLI2↓, 2,   ITGB4↓, 1,   MET↑, 1,   MMP1↓, 2,   MMP2↓, 16,   MMP7↓, 1,   MMP9↓, 20,   MMPs↓, 7,   MUC4↓, 3,   N-cadherin↓, 7,   PDGF↓, 3,   Rac1↓, 1,   Rho↝, 1,   Slug↓, 2,   Snail↓, 4,   TIMP1↑, 2,   TIMP2↑, 3,   TSC1↑, 1,   TumCA↓, 1,   TumCI↓, 18,   TumCMig↓, 16,   TumMeta↓, 18,   TumMeta↑, 2,   Twist↓, 3,   uPA↓, 6,   Vim↓, 4,   α-tubulin↓, 1,   β-catenin/ZEB1↓, 19,   p‑β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 29,   CD31/PECAM-1↓, 1,   HIF-1↓, 1,   Hif1a↓, 16,   Hif1a↑, 1,   NO↝, 1,   PGI2↓, 1,   VEGF↓, 20,   VEGFR1↓, 1,   VEGFR2/KDR/Flk1↓, 3,  

Barriers & Transport(tgid=15) ⓘ

AQPs↓, 1,   BBB↓, 1,   BBB↑, 2,   GLUT1↓, 3,   GLUT4↓, 1,   MMP↓, 23,   MMP↑, 2,   MPT↑, 3,   TRPV1↑, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CB2 / CNR2↑, 2,   CD44↓, 1,   cDC2↓, 1,   COX2/PTGS2↓, 24,   CXCL12↓, 1,   CXCR2↓, 2,   CXCR4↓, 5,   DR4↑, 3,   HMGB1↓, 1,   ICAM-1↓, 1,   IL10↓, 1,   IL10↑, 1,   IL1α↓, 1,   IL1β↓, 3,   IL6↓, 6,   IL8↓, 1,   Imm↑, 2,   Inflam↓, 11,   MCP1/CCL2↓, 1,   MIP2↓, 1,   NF-kB↓, 30,   NF-kB↑, 3,   p‑NF-kB↓, 1,   NLRP3↓, 1,   NLRP3↑, 1,   p‑p65↓, 1,   PD-L1↓, 1,   PGE2↓, 8,   PSA↓, 7,   RAGE↓, 1,   TCF↓, 1,   TLR4↝, 1,   TNF-α↓, 6,   TNF-α↑, 2,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 1,  

Cellular Microenvironment(tgid=17) ⓘ

pH↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,  

Protein Aggregation(tgid=19) ⓘ

PRNP↑, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

2/16-OHE1↑, 3,   ACE/ACE1↓, 1,   AR↓, 7,   AR↝, 2,   AR-V7?, 1,   COMT↓, 2,   CYP19?, 1,   ER-α36↝, 1,   ER(estro)↓, 1,   Estro↝, 1,   PPARα↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 1,   BioAv↓, 8,   BioAv↑, 12,   BioAv↝, 1,   BioEnh↑, 1,   ChemoSen↓, 1,   ChemoSen↑, 35,   ChemoSen∅, 1,   CompStab↓, 2,   CompStab↑, 1,   CYP1A1↓, 3,   CYP1A1↑, 1,   CYP1A2↑, 1,   CYP1B1↓, 1,   CYP3A4↓, 1,   Dose↑, 1,   Dose⇅, 1,   Dose↝, 17,   eff?, 1,   eff↓, 5,   eff↑, 14,   eff↝, 4,   GSTA1↓, 1,   Half-Life↓, 1,   Half-Life↝, 3,   MRP1/ABCC1↓, 2,   MRP1/ABCC1↝, 1,   P-gp/ABCB1↓, 3,   P-gp/ABCB1⇅, 1,   P450↓, 1,   RadioS↑, 12,   selectivity?, 1,   selectivity↑, 22,   Synergy↑, 15,   TET2↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AR↓, 7,   AR↝, 2,   ascitic↓, 1,   AST↓, 1,   BRCA1↑, 1,   creat↓, 1,   EGFR↓, 8,   HER2/EBBR2↓, 3,   hTERT/TERT↓, 2,   IL6↓, 6,   LDH↓, 1,   PD-L1↓, 1,   PSA↓, 7,   RAGE↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 24,   AntiDiabetic↑, 1,   antiNeop↑, 1,   AntiTum↑, 5,   cardioP↑, 2,   chemoP↑, 6,   chemoPv↑, 138,   chemoPv⇅, 1,   ChemoSideEff↓, 1,   hepatoP↑, 4,   mal↓, 1,   memory↑, 1,   Nausea↓, 1,   neuroP↑, 5,   OS↑, 1,   Pain↓, 1,   QoL↑, 2,   radioP↑, 3,   RenoP↑, 3,   Risk↓, 10,   TGFβR1↑, 1,   toxicity↓, 6,   toxicity↝, 3,   TumVol↓, 4,   TumW↓, 1,   Vomit↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiViral↑, 1,   GutMicro↑, 2,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,   Ingr↝, 1,  
Total Targets: 477

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 27,   Catalase↓, 1,   Catalase↑, 3,   GPx↓, 1,   GPx↑, 3,   GSH↑, 9,   GSTs↑, 3,   HO-1↑, 2,   lipid-P↓, 5,   MDA↓, 3,   NQO1↑, 2,   NRF2↑, 7,   RNS↓, 2,   ROS?, 2,   ROS↓, 30,   SAM-e↑, 1,   selenoP↑, 1,   SOD↑, 4,   TrxR↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 2,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

Insulin↑, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

15-LOX/ALOX15↓, 1,   5LO↓, 5,   ALAT↓, 1,   AMPK↑, 2,   ATP↑, 1,   ATP↝, 1,   glucose↓, 1,   LDL↓, 1,   lipidLev↓, 1,   NAD↝, 1,   NADPH↑, 1,   PKM2↓, 1,  

Cell Death(tgid=5) ⓘ

BAX↓, 1,   Casp3↓, 1,   Casp3∅, 1,   Casp9↓, 1,   Cyt‑c∅, 1,   iNOS↓, 3,   p38↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

p‑Akt↓, 1,   p‑CREB↑, 1,   ERK↑, 1,   JNK↓, 1,   MAPK↓, 2,   MAPK↑, 1,   PKCδ↓, 1,   RAS↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 1,   other↓, 2,   other↝, 4,  

Protein Folding & ER Stress(tgid=8) ⓘ

HSP70/HSPA5↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 1,   P53↓, 1,   PCNA↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

P21↑, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMPs↑, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 6,   AP-1↓, 1,   Ca+2↓, 1,   Ca+2↑, 1,   Ca+2↝, 2,   EMT↓, 1,   MMP9↓, 1,   serineP↓, 1,   TGF-β↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

NO↓, 1,  

Barriers & Transport(tgid=15) ⓘ

GastroP↑, 1,   MMP∅, 2,   TRPV1↑, 1,   TRPV3↑, 1,   VGSC↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX1↓, 1,   COX2/PTGS2↓, 9,   IL18↓, 1,   IL1β↓, 3,   IL2↑, 1,   IL4↑, 1,   IL6↓, 3,   IL8↓, 1,   Imm↑, 5,   Inflam↓, 34,   Inflam↑, 1,   NF-kB↓, 10,   PGE2↓, 1,   TNF-α↓, 7,   VitD↑, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 2,   BChE↓, 2,   MAOA↓, 1,  

Protein Aggregation(tgid=19) ⓘ

BACE/β-secretase↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

GR↓, 1,   PPARα↑, 1,   p‑PPARγ↓, 1,   testos↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 8,   BioAv↑, 10,   BioAv⇅, 2,   BioAv↝, 10,   CompStab↝, 1,   CYP2E1↓, 1,   Dose↓, 1,   Dose↑, 3,   Dose↝, 7,   eff↑, 9,   GSTA1↑, 1,   Half-Life?, 1,   Half-Life↓, 1,   Half-Life↝, 4,   selectivity↑, 1,   Synergy↑, 3,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   BMD↑, 1,   BP↓, 2,   Calcium↑, 1,   CRP↓, 1,   hs-CRP↓, 1,   IL6↓, 3,   Mag↑, 1,   VitD↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   antiAll↑, 3,   AntiCan↓, 1,   AntiCan↑, 3,   AntiDiabetic↓, 1,   AntiDiabetic↑, 10,   cardioP↑, 8,   cardioP⇅, 1,   chemoP↑, 2,   chemoPv↑, 34,   ChemoSideEff↓, 1,   cognitive↑, 3,   hepatoP↑, 10,   memory↑, 4,   neuroP↑, 11,   Obesity↓, 2,   OS↑, 1,   Pain↓, 3,   radioP↑, 1,   RenoP↑, 1,   Risk↓, 2,   Stroke↓, 1,   toxicity↓, 8,   toxicity↝, 1,   Wound Healing↑, 3,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 1,   AntiFungal↑, 1,   Bacteria↓, 6,   Diar↓, 1,   GutMicro↑, 1,   GutMicro∅, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 1,  
Total Targets: 153

Scientific Paper Hit Count for: chemoPv, ChemoPreventive
8 Curcumin
7 Phenethyl isothiocyanate
6 Chemotherapy
6 Capsaicin
6 Chrysin
6 Resveratrol
6 Quercetin
6 Sulforaphane (mainly Broccoli)
4 Apigenin (mainly Parsley)
4 Diindolylmethane
4 Indole-3-carbinol
4 D-limonene
4 Fisetin
4 Nimbolide
4 Thymoquinone
3 EGCG (Epigallocatechin Gallate)
3 Betulinic acid
3 Chlorophyllin
3 Chocolate
3 α-Santalol/Sandalwood oil
2 Astaxanthin
2 Arctigenin
2 Biochanin A
2 Carvacrol
2 Celecoxib
2 Cucurbitacin
2 methylseleninic acid
2 Genistein (soy isoflavone)
2 Eugenol
2 Formononetin
2 Grapeseed extract
2 Hibiscus sabdariffa
2 Inositol
2 phytic acid, Inositol hexakisphosphate
2 Isovitexin
2 Vitexin
2 Licochalcone A
1 Annona atemoya Seed Extract
1 Silver-NanoParticles
1 probiotics
1 Allicin (mainly Garlic)
1 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
1 DTS(dibenzyl trisulphide) from Anamu
1 Anethole/trans-Anethole
1 Luteolin
1 Ashwagandha(Withaferin A)
1 Berberine
1 Beta-Caryophyllene
1 Boron
1 Boswellia (frankincense)
1 Bruteridin(bergamot juice)
1 Butyrate
1 Caffeic acid
1 Carnosic acid
1 Calcium
1 Caffeic Acid Phenethyl Ester (CAPE)
1 Celastrol
1 Chlorogenic acid
1 Cinnamon
1 Coenzyme Q10
1 Carica papaya leaf extract
1 Calorie Restriction Mimetics
1 Crocetin
1 Carvone
1 Cynara scolymus/Globe Artichoke/Artichoke Extract
1 Deguelin
1 Diclofenac
1 Dandelion Root
1 Ginkgo biloba-EGb 761
1 5-fluorouracil
1 Garcinol
1 Ginger/6-Shogaol/Gingerol
1 Graviola
1 Honokiol
1 Hops (Humulus lupulus)
1 Hyperoside
1 Inulin Prebiotic
1 Isoliquiritigenin
1 isoflavones
1 Juglone
1 Kaempferol
1 Lasiodin
1 SDG/lignans
1 Magnolol
1 mebendazole
1 Sulindac
1 Methyl salicylate / Sweet Birch oil
1 Aspirin
1 Lemon Balm/Melissa officinalis
1 Moringa oleifera
1 Morin
1 Oleuropein
1 Psoralidin
1 Rutin
1 buckwheat sprouts
1 Selenium
1 Selenium NanoParticles
1 Silymarin (Milk Thistle) silibinin
1 Shikonin
1 Selenite (Sodium)
1 Sutherlandioside D
1 Ursolic acid
1 Vitamin C (Ascorbic Acid)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1417  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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