HSP70/HSPA5 Cancer Research Results

HSP70/HSPA5, heat shock proteins 70 kilodalton: Click to Expand ⟱
Source:
Type:
Also known as HSPA5
Enhanced expression of Hsp70 is associated with tumorigenesis for breast cancer, endometrial cancer, gastric cancer, and acute leukemia; with poor prognoses.
-These adenosine triphosphatases unfold misfolded or denatured proteins and can keep these proteins in an unfolded, folding-competent state. They also protect nascently translating proteins, promote the cellular or organellar transport of proteins, reduce proteotoxic protein aggregates and serve general housekeeping roles in maintaining protein homeostasis.
-HSP70 family of proteins can be thought of as a potent buffering system for cellular stress, either from extrinsic (physiological, viral and environmental) or intrinsic (replicative or oncogenic) stimuli. As such, this family serves a critical survival function in the cell. Not surprisingly, cancer cells rely heavily on this buffering system for survival. The overwhelming majority of human tumors overexpress HSP70 family members, and expression of these proteins is typically a marker for poor prognosis.
-HSP70 helps cancer cells survive under stressful conditions, such as hypoxia or nutrient deprivation, by preventing protein misfolding and aggregation. This allows cancer cells to maintain their proliferative capacity.
-Tumor Progression: Elevated levels of HSP70 have been associated with tumor progression and metastasis.
Scientific Papers found: Click to Expand⟱
3469- MF,    Pulsed Electromagnetic Fields (PEMF)—Physiological Response and Its Potential in Trauma Treatment
- Review, Nor, NA
*eff↑, *eff↝, *other↑, Ca+2↑, ROS↑, HSP70/HSPA5↑, *NOTCH↑, *HEY1↑, *p38↑, *MAPK↑,
524- MF,    Inhibition of Angiogenesis Mediated by Extremely Low-Frequency Magnetic Fields (ELF-MFs)
- vitro+vivo, PC, MS-1 - vitro+vivo, PC, HUVECs
other↓, TumCP↓, TumCMig↓, VEGFR2/KDR/Flk1↓, TumVol↓, HSP70/HSPA5↓, HSP90↓, TumCCA↑, angioG↓,
526- MF,    Inhibition of Cancer Cell Growth by Exposure to a Specific Time-Varying Electromagnetic Field Involves T-Type Calcium Channels
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF7 - in-vitro, Pca, HeLa - vitro+vivo, Melanoma, B16-BL6 - in-vitro, Nor, HEK293
TumCG↓, Ca+2↑, selectivity↑, *Ca+2∅, ROS↑, HSP70/HSPA5↑, AntiCan↑,
493- MF,    Extremely low-frequency electromagnetic field induces acetylation of heat shock proteins and enhances protein folding
- in-vitro, NA, HEK293 - in-vitro, Liver, AML12
ATP↑, HSP70/HSPA5↓, HSP90↓,
492- MF,    Weak electromagnetic fields (50 Hz) elicit a stress response in human cells
- in-vitro, AML, HL-60
HSP70/HSPA5↑,
519- MF,    Effects of 50-Hz magnetic field exposure on superoxide radical anion formation and HSP70 induction in human K562 cells
- in-vitro, AML, K562
HSP70/HSPA5↑,
194- MF,    Electromagnetic Field as a Treatment for Cerebral Ischemic Stroke
- Review, Stroke, NA
*BAD↓, *BAX↓, *Casp3↓, *Bcl-xL↑, *p‑Akt↑, *MMP9↓, *p‑ERK↑, *HIF-1↓, *ROS↓, *VEGF↑, *Ca+2↓, *SOD↑, *IL2↑, *p38↑, *HSP70/HSPA5↑, *Apoptosis↓, *ROS↓, *NO↓,
8692- MLT,    Melatonin as a Radio-Sensitizer in Cancer
- Review, Var, NA
RadioS↑, radioP↑, ROS↑, DNArepair↓, angioG↓, Inflam↓, Apoptosis↑, Telomerase↓, HSP70/HSPA5↑, P53↑, Glycolysis↓, Dose?, OS∅,
8673- MLT,    Therapeutic Potential of Melatonin in Gastrointestinal Cancers: Molecular Mechanisms, Preclinical Evidence and Clinical Implications
- Review, GC, NA
ChemoSen↑, TumVol↓, β-catenin/ZEB1↓, Risk↓, radioP↑, Mucositis↓, Dose↝, toxicity↓, BioAv↓, *antiOx↑, *SOD↑, *GPx↑, *Catalase↑, *NRF2↑, Apoptosis↑, Estro↝, Telomerase↓, *ROS↓, angioG↓, Imm↑, TumCCA↑, Glycolysis↓, OXPHOS↑, mTORC1↓, VEGF↓, Hif1a↓, ROS↓, TumAuto↓, HSP70/HSPA5↓, PI3K↓, Akt↓, mTOR↓, BAX↑, Casp↑, Cyt‑c↑, tumCV↓, TumCMig↓, TumCI↓, TumVol↓, TumW↓, P21↑, P53↑, Synergy↑, ER Stress↑, Synergy↑, RadioS↑, eff↑, eff↑, fatigue↓, Sleep↑,
8808- MT/VAE,    A fermented Mistletoe (Viscum album L.) extract elicits markers characteristic for immunogenic cell death driven by endoplasmic reticulum stress in vitro
- in-vitro, BC, SkBr3 - in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF7 - in-vitro, NA, B16-F10
p‑eIF2α↑, CRT↑, HSP70/HSPA5↑, HSP90↑, mt-ROS↑, Imm↑, ER Stress↑,
6486- Nimb,    Nimbolide: promising agent for prevention and treatment of chronic diseases
- Review, Var, NA - Review, AD, NA
*other↝, *Inflam↓, AntiCan↑, *Bacteria↓, *AntiViral↑, *neuroP↑, *hepatoP↑, *ROS?, *NRF2↑, *HO-1↑, *TLR4↓, *NF-kB↓, *AChE↓, *Aβ↓, *GSK‐3β↓, *LDL↓, *DNAdam↓, *lipid-P↓, *antiOx↑, *SOD1↑, *GSH↑, *IL6↓, *IL1β↓, *STAT3↓, *GPx↑, *Catalase↑, *MDA↓, *AntiDiabetic↑, *HDL↓, *MCP1/CCL2↓, *VEGF↓, *MMP9↓, *GutMicro↑, TumCP↓, TumCCA↑, TumCMig↓, NF-kB↓, ROS↑, PI3K↓, Akt↓, mTOR↓, ERK↓, EMT↓, TumMeta↓, ChemoSen↑, eff↑, selectivity↑, CDK4↓, CDK6↓, Wnt↓, β-catenin/ZEB1↓, STAT3↓, MMP2↓, Sp1/3/4↓, AP-1↓, P21↑, *AntiArt↑, *IL23↓, *IL17↓, *IFN-γ↓, *HSP70/HSPA5↓,
3249- PBG,    Can Propolis Be a Useful Adjuvant in Brain and Neurological Disorders and Injuries? A Systematic Scoping Review of the Latest Experimental Evidence
- Review, Var, NA
*Inflam↓, *ROS↓, *MDA↓, *TNF-α↓, *NO↓, *iNOS↓, *SOD↑, *GPx↑, *GSR↓, *GSH↑, *neuroP↑, *IL6↓, *MMP2↓, *MMP9↓, *MCP1/CCL2↓, *HSP70/HSPA5↑, *motorD↑, *Pain↓, *VCAM-1↓, *NF-kB↓, *MAPK↓, *JNK↓, *IL1β↓, *AChE↓, *toxicity∅, cognitive↑,
3343- QC,    Quercetin, a Flavonoid with Great Pharmacological Capacity
- Review, Var, NA - Review, AD, NA - Review, Arthritis, NA
*antiOx↑, *ROS↓, *angioG↓, *Inflam↓, *BioAv↓, *Half-Life↑, *GSH↑, *SOD↑, *Catalase↑, *Nrf1↑, *BP↓, *cardioP↑, *IL10↓, *TNF-α↓, *Aβ↓, *GSK‐3β↓, *tau↓, *neuroP↑, *Pain↓, *COX2/PTGS2↓, *NRF2↑, *HO-1↑, *IL1β↓, *IL17↓, *MCP1/CCL2↓, PKCδ↓, ERK↓, BAX↓, cMyc↓, KRAS↓, ROS↓, selectivity↑, tumCV↓, Apoptosis↑, TumCCA↑, ChemoSen↑, P-gp/ABCB1↓, Synergy↑, Synergy↑, Synergy↑, Synergy↑, CycB/CCNB1↓, CDK1↓, CDK4↓, CDK2↓, TOP2↓, Cyt‑c↑, cl‑PARP↑, MMP↓, HSP70/HSPA5↓, HSP90↓, MDM2↓, RAS↓, eff↑,
3369- QC,    Pharmacological basis and new insights of quercetin action in respect to its anti-cancer effects
- Review, Pca, NA
FAK↓, TumCCA↑, p‑pRB↓, CDK2↑, CycB/CCNB1↓, CDK1↓, EMT↓, PI3K↓, MAPK↓, Wnt↓, ROS↑, miR-21↑, Akt↓, NF-kB↓, FasL↑, Bak↑, BAX↑, Bcl-2↓, Casp3↓, Casp9↑, P53↑, p38↑, MAPK↑, Cyt‑c↑, PARP↓, CHOP/DDIT3↑, ROS↓, LDH↑, GRP78/BiP↑, ERK↑, MDA↓, SOD↑, GSH↑, NRF2↑, VEGF↓, PDGF↓, EGF↓, FGF↓, TNF-α↓, TGF-β↓, VEGFR2/KDR/Flk1↓, EGFR↓, FGFR1↓, mTOR↓, cMyc↓, MMPs↓, LC3B-II↑, Beclin-1/ATG6↑, IL1β↓, CRP↓, IL10↓, COX2/PTGS2↓, IL6↓, TLR4↓, Shh↓, HER2/EBBR2↓, NOTCH↓, DR5↑, HSP70/HSPA5↓, CSCs↓, angioG↓, MMP2↓, MMP9↓, IGFBP3↑, uPA↓, uPAR↓, RAS↓, Raf↓, TSP-1↑,
94- QC,  HPT,    Effects of quercetin on the heat-induced cytotoxicity of prostate cancer cells
- in-vitro, Pca, LNCaP - in-vitro, Pca, PC3 - in-vitro, Pca, JCA-1
HSP70/HSPA5↓, TumCCA↑, TumCG↓, Synergy↑,
2566- RES,    A comprehensive review on the neuroprotective potential of resveratrol in ischemic stroke
- Review, Stroke, NA
*neuroP↑, *NRF2↑, *SIRT1↑, *PGC-1α↑, *FOXO↑, *HO-1↑, *NQO1↑, *ROS↓, *BP↓, *BioAv↓, *Half-Life↝, *AMPK↑, *GSK‐3β↓, *eff↑, *AntiAg↑, *BBB↓, *Inflam↓, *MPO↓, *TLR4↓, *NF-kB↓, *p65↓, *MMP9↓, *TNF-α↓, *IL1β↓, *PPARγ↑, *MMP↑, *ATP↑, *Cyt‑c∅, *mt-lipid-P↓, *H2O2↓, *HSP70/HSPA5↝, *Mets↝, *eff↑, *eff↑, *motorD↑, *MDA↓, *NADH:NAD↑, eff↑, eff↑,
3490- RF,    Multidimensional insights into the repeated electromagnetic field stimulation and biosystems interaction in aging and age-related diseases
- Review, AD, NA - Review, Park, NA
*OS↑, *memory↑, *cognitive↑, *memory↑, *Aβ↓, *eff↑, *HSF1↑, *HSP70/HSPA5↑,
3002- RosA,    Anticancer Effects of Rosemary (Rosmarinus officinalis L.) Extract and Rosemary Extract Polyphenols
- Review, Var, NA
TumCG↓, TumCP↓, TumCCA↑, ChemoSen↑, NRF2↑, PERK↑, SESN2↑, HO-1↑, cl‑Casp3↑, ROS↑, UPR↑, ER Stress↑, CHOP/DDIT3↑, HER2/EBBR2↓, ER-α36↓, PSA↓, BAX↑, AR↓, P-gp/ABCB1↓, Cyt‑c↑, HSP70/HSPA5↑, eff↑, p‑Akt↓, p‑mTOR↓, p‑P70S6K↓, cl‑PARP↑, Synergy↑,
3663- SFN,    Efficacy of Sulforaphane in Neurodegenerative Diseases
- Review, AD, NA - Review, Park, NA
*antiOx↑, *Inflam↓, *Half-Life↝, *NRF2↑, *NQO1↑, *HO-1↑, *TrxR↑, *ROS↓, *TNF-α↓, *IL1β↓, *IL6↓, *iNOS↓, *COX2/PTGS2↓, *Aβ↓, *GSH↑, *cognitive↑, *BACE/β-secretase↓, *HSP70/HSPA5↑, *neuroP↑, *ROS↓, *BBB↑, *MMP9↓,
3664- SFN,    Sulforaphane Upregulates the Heat Shock Protein Co-Chaperone CHIP and Clears Amyloid-β and Tau in a Mouse Model of Alzheimer's Disease
- in-vivo, AD, NA
*CHIP↑, *HSP70/HSPA5↑, *Aβ↓, *tau↓,
3658- SFN,    Pre-Clinical Neuroprotective Evidences and Plausible Mechanisms of Sulforaphane in Alzheimer’s Disease
- Review, AD, NA
*NRF2↑, *antiOx↑, *neuroP↑, *Aβ↓, *BACE/β-secretase↓, *NQO1↑, *IL1β↓, *TNF-α↓, *IL6↓, *COX2/PTGS2↓, *iNOS↓, *NF-kB↓, *NLRP3↓, *Ca+2↓, *GSH↑, *MDA↓, *ROS↓, *SOD↑, *HO-1↑, *TrxR↑, *cognitive↑, *tau↓, *HSP70/HSPA5↑,
1726- SFN,    Sulforaphane: A Broccoli Bioactive Phytocompound with Cancer Preventive Potential
- Review, Var, NA
Dose↝, eff↝, IL1β↓, IL6↓, IL12↓, TNF-α↓, COX2/PTGS2↓, CXCR4↓, MPO↓, HSP70/HSPA5↓, HSP90↓, VCAM-1↓, IKKα↓, NF-kB↓, HO-1↑, Casp3↑, Casp7↑, Casp8↑, Casp9↑, cl‑PARP↑, Cyt‑c↑, Diablo↑, CHOP/DDIT3↑, survivin↓, XIAP↓, p38↑, Fas↑, PUMA↑, VEGF↓, Hif1a↓, Twist↓, Zeb1↓, Vim↓, MMP2↓, MMP9↓, E-cadherin↑, N-cadherin↓, Snail↓, CD44↓, cycD1/CCND1↓, cycA1/CCNA1↓, CycB/CCNB1↓, cycE/CCNE↓, CDK4↓, CDK6↓, p50↓, P53↑, P21↑, GSH↑, SOD↑, GSTs↑, mTOR↓, Akt↓, PI3K↓, β-catenin/ZEB1↓, IGF-1↓, cMyc↓, CSCs↓,
1050- SK,    Shikonin improves the effectiveness of PD-1 blockade in colorectal cancer by enhancing immunogenicity via Hsp70 upregulation
- in-vitro, Colon, CT26
HSP70/HSPA5↑, ROS↑, PKM2↓,
2084- TQ,    Thymoquinone, as an anticancer molecule: from basic research to clinical investigation
- Review, Var, NA
*ROS↓, *chemoPv↑, ROS↑, ROS⇅, MUC4↓, selectivity↑, AR↓, cycD1/CCND1↓, Bcl-2↓, Bcl-xL↓, survivin↓, Mcl-1↓, VEGF↓, cl‑PARP↑, ROS↑, HSP70/HSPA5↑, P53↑, miR-34a↑, Rac1↓, TumCCA↑, NOTCH↓, NF-kB↓, IκB↓, p‑p65↓, IAP1↓, IAP2/BIRC3↑, XIAP↓, TNF-α↓, COX2/PTGS2↓, Inflam↓, α-tubulin↓, Twist↓, EMT↓, mTOR↓, PI3K↓, Akt↓, BioAv↓, ChemoSen↑, CompStab↑, PTEN↑, chemoPv↑, RadioS↑, *Half-Life↝, *BioAv↝,
2091- TQ,    Determination of anti-cancer effects of Nigella sativa seed oil on MCF7 breast and AGS gastric cancer cells
- in-vitro, BC, MCF7 - in-vitro, GC, AGS
Dose↝, Casp3↑, Bcl-2↓, MMP2↓, MMP9↓, HSP70/HSPA5↓,
2109- TQ,    Thymoquinone Induces Mitochondria-Mediated Apoptosis in Acute Lymphoblastic Leukaemia in Vitro
- in-vitro, AML, CEM
Apoptosis↓, Bcl-2↓, BAX↑, ROS↑, HSP70/HSPA5↑, Casp3↑, Casp8↑,

Showing Research Papers: 51 to 76 of 76
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 76

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

Catalase↑, 1,   GPx↓, 1,   GPx4↓, 2,   GPx4↑, 1,   GSH↓, 4,   GSH↑, 2,   GSH∅, 1,   GSTs↓, 1,   GSTs↑, 1,   HO-1↑, 5,   HO-2↑, 1,   Iron↑, 2,   Keap1↓, 1,   lipid-P↑, 2,   MDA↓, 1,   MDA↑, 4,   MPO↓, 1,   NFE2L2↑, 1,   NRF2↓, 2,   NRF2↑, 4,   ROS↓, 4,   ROS↑, 30,   ROS⇅, 2,   mt-ROS↑, 1,   SOD↑, 3,  

Metal & Cofactor Biology(tgid=2) ⓘ

FTH1↑, 1,   FTL↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC2↓, 1,   CDC25↓, 1,   EGF↓, 2,   ETC↓, 1,   OXPHOS↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACC↑, 2,   ALAT↝, 1,   AMPK↑, 2,   ATP↑, 1,   e-ATP↑, 1,   GlucoseCon↓, 1,   GlucoseCon∅, 1,   Glycolysis↓, 3,   lactateProd↓, 1,   lactateProd∅, 1,   PKM2↓, 2,   SIRT1↑, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 1,   Apoptosis↑, 15,   mt-Apoptosis↑, 1,   BAD↑, 3,   Bak↑, 1,   BAX↓, 1,   BAX↑, 10,   Bax:Bcl2↑, 1,   Bcl-2↓, 10,   Bcl-xL↓, 2,   BID↑, 2,   BIM↑, 2,   BNIP3↝, 1,   Casp↑, 2,   Casp12↑, 1,   Casp3↓, 1,   Casp3↑, 11,   cl‑Casp3↑, 4,   Casp7↑, 3,   Casp8↑, 2,   cl‑Casp8↑, 1,   Casp9↑, 6,   cFLIP↓, 1,   Cyt‑c↑, 11,   Diablo↑, 4,   DR5↑, 3,   FADD↑, 1,   Fas↑, 4,   FasL↑, 2,   Ferroptosis↑, 3,   IAP1↓, 2,   IAP2/BIRC3↑, 1,   ICD↑, 1,   iNOS↓, 3,   Mcl-1↓, 6,   MDM2↓, 1,   p38↓, 1,   p38↑, 4,   PUMA↑, 1,   survivin↓, 3,   TRAIL↑, 1,   TumCD↑, 2,   XIAP↓, 2,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 13,   Akt↑, 1,   p‑Akt↓, 1,   AMPKα↑, 1,   EGFR↓, 5,   ERK↓, 4,   ERK↑, 2,   p‑ERK↓, 1,   FGFR1↓, 1,   HER2/EBBR2↓, 2,   IGF-1R↓, 1,   IKKα↓, 1,   IκB↓, 1,   JNK↑, 3,   MAPK↓, 2,   MAPK↑, 1,   MEK↓, 1,   mTOR↓, 10,   p‑mTOR↓, 1,   p70S6↓, 2,   p‑P70S6K↓, 1,   p85S6K↓, 1,   PI3K↓, 11,   PKA↓, 1,   PKCδ↓, 1,   PTEN↑, 1,   Raf↓, 1,   RAS↓, 2,   Sp1/3/4↓, 1,   Src↓, 2,   STAT3↓, 3,   p‑STAT3↓, 1,   STAT5↓, 1,   TSC2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF4↓, 1,   ATF4↑, 2,   ATFs↑, 1,   cJun↓, 3,   cMyc↓, 3,   HATs↓, 1,   HDAC↓, 1,   miR-21↑, 1,   miR-34a↑, 1,   Myc↓, 1,   n-MYC↓, 1,   OCT4↓, 2,   other↓, 1,   other↝, 1,   SOX2↓, 1,   tumCV↓, 7,   USF1↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 8,   CRT↑, 2,   e-CRT↑, 1,   p‑eIF2α↑, 2,   ER Stress↑, 13,   GRP78/BiP↑, 6,   GRP94↑, 2,   HSF1↓, 1,   HSP27↓, 2,   HSP27↝, 1,   HSP70/HSPA5↓, 24,   HSP70/HSPA5↑, 28,   HSP70/HSPA5⇅, 1,   HSP70/HSPA5↝, 1,   HSP70/HSPA5∅, 1,   e-HSP70/HSPA5↓, 1,   e-HSP70/HSPA5↑, 1,   HSP90↓, 10,   HSP90↑, 3,   e-HSP90↑, 2,   HSPs↑, 1,   IRE1↑, 2,   PERK↑, 2,   p‑PERK↑, 1,   Proteasome↓, 1,   UPR↑, 3,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↑, 2,   Beclin-1/ATG6⇅, 1,   LC3B-II↑, 1,   SESN2↑, 1,   TumAuto↓, 1,   TumAuto↑, 2,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 5,   DNArepair↓, 3,   P53?, 1,   P53↑, 7,   PARP↓, 1,   cl‑PARP↑, 11,   Telomerase↓, 2,   TOP2↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 3,   CDK2↓, 6,   CDK2↑, 1,   CDK4↓, 10,   CDK6↓, 7,   Cyc↓, 1,   cycA1/CCNA1↓, 2,   CycB/CCNB1↓, 3,   cycD1/CCND1↓, 9,   cycE/CCNE↓, 4,   Ki-67↓, 1,   P21↑, 7,   p27/CDKN1B↑, 1,   p‑pRB↓, 1,   Securin↓, 1,   TumCCA↑, 18,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CD133↓, 1,   cFos↓, 3,   cFos↑, 1,   CSCs↓, 5,   FGF↓, 1,   HH↓, 1,   IGF-1↓, 2,   IGFBP3↑, 1,   Ki-67↓, 1,   mTORC1↓, 2,   Nanog↓, 1,   Nestin↓, 1,   NOTCH↓, 2,   NOTCH2↓, 1,   Shh↓, 1,   TumCG↓, 3,   TumCP↓, 11,   TumCP↑, 1,   Wnt↓, 5,  

Migration(tgid=13) ⓘ

AP-1↓, 1,   ATPase↓, 2,   AXL↓, 1,   BACH1↑, 1,   Ca+2↑, 4,   CAFs/TAFs↓, 1,   E-cadherin↓, 2,   E-cadherin↑, 3,   EMT↓, 7,   FAK↓, 2,   Fibronectin↓, 2,   KRAS↓, 1,   MET↓, 1,   MMP1↓, 2,   MMP2↓, 10,   MMP3↓, 2,   MMP7↓, 3,   MMP9↓, 11,   MMPs↓, 2,   MUC4↓, 1,   N-cadherin↓, 4,   NCAM↓, 1,   PDGF↓, 1,   Rac1↓, 1,   Slug↓, 1,   Snail?, 1,   Snail↓, 5,   TGF-β↓, 2,   TSP-1↑, 1,   TumCI↓, 4,   TumCMig↓, 5,   TumMeta↓, 4,   Twist↓, 4,   uPA↓, 5,   uPAR↓, 1,   Vim↓, 6,   Zeb1↓, 3,   ZEB2↓, 1,   α-tubulin↓, 1,   α-tubulin↑, 1,   β-catenin/ZEB1↓, 7,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 8,   eNOS↓, 1,   Hif1a↓, 5,   Hypoxia↓, 2,   NO↓, 1,   NO↑, 1,   REL↑, 1,   VCAM-1↓, 1,   VEGF↓, 12,   VEGFR2/KDR/Flk1↓, 3,  

Barriers & Transport(tgid=15) ⓘ

EPR↑, 2,   GLUT1↓, 1,   MMP↓, 6,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD44↓, 1,   COX2/PTGS2↓, 10,   CXCR4↓, 1,   CXCR4↑, 1,   HMGB1↑, 1,   e-HMGB1↑, 1,   IL10↓, 1,   IL12↓, 1,   IL1β↓, 2,   IL4↓, 1,   IL6↓, 5,   Imm↑, 3,   Inflam↓, 4,   M2 MC↓, 1,   NF-kB↓, 10,   NF-kB↑, 1,   p50↓, 1,   p65↓, 1,   p‑p65↓, 1,   PGE2↓, 3,   PSA↓, 1,   TCF↑, 1,   TLR4↓, 2,   TNF-α↓, 6,  

Cellular Microenvironment(tgid=17) ⓘ

pH↝, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 2,   ER-α36↓, 1,   Estro↝, 1,   PPARγ↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 4,   ChemoSen↑, 11,   ChemoSen⇅, 1,   CompStab↑, 1,   Dose?, 1,   Dose↝, 10,   Dose∅, 1,   eff↓, 2,   eff↑, 13,   eff↝, 1,   Half-Life↝, 1,   P-gp/ABCB1↓, 2,   P-gp/ABCB1⇅, 1,   RadioS↑, 6,   selectivity↑, 6,   Synergy↑, 19,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↝, 1,   ALP↝, 1,   AR↓, 2,   AST↝, 1,   BloodF↑, 2,   CRP↓, 1,   EGFR↓, 5,   HER2/EBBR2↓, 2,   IL6↓, 5,   KRAS↓, 1,   LDH↓, 1,   LDH↑, 1,   Myc↓, 1,   PSA↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 5,   AntiTum↓, 1,   AntiTum↑, 2,   chemoP↑, 1,   chemoPv↑, 2,   cognitive↑, 1,   fatigue↓, 1,   LC↑, 2,   Mucositis↓, 1,   OS↑, 2,   OS∅, 1,   QoL↑, 1,   radioP↑, 2,   Risk↓, 1,   Sleep↑, 1,   toxicity↓, 2,   TumVol↓, 4,   TumVol⇅, 1,   TumW↓, 1,   TumW⇅, 1,  
Total Targets: 347

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 12,   Catalase↑, 8,   GPx↑, 4,   GSH↑, 12,   GSR↓, 1,   H2O2↓, 1,   HDL↓, 1,   HO-1↑, 10,   lipid-P↓, 3,   mt-lipid-P↓, 1,   MDA↓, 8,   MPO↓, 3,   NOX4↓, 1,   NQO1↑, 4,   Nrf1↑, 1,   NRF2↑, 14,   ROS?, 1,   ROS↓, 22,   ROS∅, 1,   SOD↑, 15,   SOD1↑, 1,   SOD2↓, 1,   TBARS↓, 1,   TOS↓, 1,   Trx↓, 1,   TrxR↑, 2,  

Metal & Cofactor Biology(tgid=2) ⓘ

Mets↝, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

Insulin↑, 1,   mtDam↑, 1,   PGC-1α↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 1,   AMPK↑, 2,   ATP↑, 1,   GAPDH↑, 1,   GSK‐3β↓, 4,   LDL↓, 2,   NADH:NAD↑, 1,   NADPH↑, 1,   PONs↓, 1,   SIRT1↑, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 2,   BAD↓, 1,   BAX↓, 4,   Bcl-2↑, 1,   Bcl-xL↑, 1,   Casp3↓, 5,   Casp9↓, 1,   Cyt‑c↓, 2,   Cyt‑c↑, 1,   Cyt‑c∅, 1,   HEY1↑, 1,   iNOS↓, 8,   p38↑, 2,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 1,   Akt↑, 2,   p‑Akt↑, 1,   ERK↑, 2,   p‑ERK↑, 1,   JAK2↓, 1,   JNK↓, 1,   MAPK↓, 2,   MAPK↑, 1,   PI3K↓, 1,   STAT3↓, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

p‑cMyc↑, 1,   FOXO↑, 1,   HDAC?, 1,   other↑, 3,   other↝, 3,  

Protein Folding & ER Stress(tgid=8) ⓘ

ER Stress↓, 1,   HSF1↑, 1,   HSP70/HSPA5↓, 1,   HSP70/HSPA5↑, 20,   HSP70/HSPA5↝, 1,   HSPs↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 1,   PARP↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CHIP↑, 2,   Diff↑, 1,   NOTCH↑, 1,   TumCG↑, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 1,   Ca+2↓, 2,   Ca+2∅, 1,   COL1↑, 1,   LAMs↑, 1,   MMP2↓, 1,   MMP9↓, 7,   Smad1↑, 1,   TGF-β↑, 1,   α-SMA↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   angioG↑, 1,   p‑eNOS↑, 1,   HIF-1↓, 1,   HIF2a↑, 1,   NO↓, 3,   NO↑, 3,   VCAM-1↓, 1,   VEGF↓, 1,   VEGF↑, 2,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 1,   BBB↑, 1,   GastroP↑, 1,   MMP↑, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX1↓, 1,   COX2/PTGS2↓, 7,   CXCR4↓, 1,   IFN-γ↓, 1,   IL10↓, 1,   IL17↓, 3,   IL18↓, 1,   IL1β↓, 11,   IL2↓, 1,   IL2↑, 1,   IL23↓, 1,   IL6↓, 7,   IL8↓, 1,   Imm↑, 1,   Inflam↓, 18,   MCP1/CCL2↓, 3,   MCP1/CCL2↑, 1,   NeuroI↓, 1,   NF-kB↓, 9,   NLRP3↓, 1,   p65↓, 1,   PGE2↓, 3,   PGE2↑, 2,   TLR4↓, 2,   TNF-α↓, 11,   TNF-α↑, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 4,   BChE↓, 2,   BDNF↓, 1,   BDNF↑, 1,  

Protein Aggregation(tgid=19) ⓘ

APP↓, 1,   Aβ↓, 7,   BACE/β-secretase↓, 4,   tau↓, 4,   p‑tau↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

PPARγ↑, 1,   RAAS↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 3,   BioAv↑, 2,   BioAv↝, 1,   Dose⇅, 1,   eff↑, 6,   eff↝, 2,   Half-Life↑, 1,   Half-Life↝, 4,  

Clinical Biomarkers(tgid=22) ⓘ

BMD↑, 1,   BP↓, 2,   CRP↓, 1,   IL6↓, 7,   TC↓, 1,   TG/TAG↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiArt↑, 2,   AntiDiabetic↑, 3,   antiPs↑, 1,   AntiTum↑, 1,   cardioP↑, 4,   chemoPv↑, 1,   cognitive↑, 7,   hepatoP↑, 2,   memory↑, 6,   motorD↑, 3,   neuroP↑, 14,   OS↑, 1,   Pain↓, 2,   toxicity↓, 3,   toxicity∅, 1,   Wound Healing↑, 2,  

Infection & Microbiome(tgid=24) ⓘ

AntiViral↑, 2,   Bacteria↓, 2,   Diar↓, 1,   GutMicro↑, 1,  
Total Targets: 177

Scientific Paper Hit Count for: HSP70/HSPA5, heat shock proteins 70 kilodalton
14 Magnetic Fields
5 Sulforaphane (mainly Broccoli)
4 Fisetin
4 Hyperthermia
3 Ashwagandha(Withaferin A)
3 Quercetin
3 Thymoquinone
2 Allicin (mainly Garlic)
2 Artemisinin
2 Berberine
2 Boron
2 Caffeic acid
2 Celastrol
2 Curcumin
2 Graviola
2 Melatonin
1 DTS(dibenzyl trisulphide) from Anamu
1 Biochanin A
1 Betulinic acid
1 Benzyl isothiocyanate
1 Bortezomib
1 Bullatacin
1 Capsaicin
1 Chlorophyllin
1 Gemcitabine (Gemzar)
1 Chrysin
1 EGCG (Epigallocatechin Gallate)
1 Evodiamine
1 Ferulic acid
1 Gambogic Acid
1 Radiotherapy/Radiation
1 isoquercitrin
1 Isothiocyanates
1 Kaempferol
1 Licochalcone A
1 Methylene blue
1 Mistletoe/Viscum album Extracts
1 Nimbolide
1 Propolis -bee glue
1 Resveratrol
1 Radio Frequency
1 Rosmarinic acid
1 Shikonin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:148  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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