IKKα Cancer Research Results

IKKα, IκB kinase alpha): Click to Expand ⟱
Source:
Type:
Expression of genes involved in nuclear factor (NF)-kappaB activation (NF-κB, IKKα) IKKα (IκB kinase alpha) is a critical component of the NF-κB signaling pathway, which plays a significant role in regulating immune responses, inflammation, and cell survival.
The NF-κB pathway, activated by IKKα, can lead to the production of pro-Inhibitors of the NF-κB pathway, including those targeting IKKα, are being investigated for their potential to treat various cancers.inflammatory cytokines that may create a tumor-promoting microenvironment.
Scientific Papers found: Click to Expand⟱
2957- PL,    Piperlongumine Induces Cell Cycle Arrest via Reactive Oxygen Species Accumulation and IKKβ Suppression in Human Breast Cancer Cells
- in-vitro, BC, MCF7
TumCP↓, TumCMig↓, TumCCA↑, ROS↑, H2O2↑, GSH↓, IKKα↓, NF-kB↓, P21↑, eff↓,
2948- PL,    The promising potential of piperlongumine as an emerging therapeutics for cancer
- Review, Var, NA
tumCV↓, TumCP↓, TumCI↓, angioG↓, EMT↓, TumMeta↓, *hepatoP↑, *lipid-P↓, *GSH↑, cardioP↑, CycB/CCNB1↓, cycD1/CCND1↓, CDK2↓, CDK1↓, CDK4↓, CDK6↓, PCNA↓, Akt↓, mTOR↓, Glycolysis↓, NF-kB↓, IKKα↓, JAK1↓, JAK2↓, STAT3↓, ERK↓, cFos↓, Slug↓, E-cadherin↑, TOP2↓, P53↑, P21↑, Bcl-2↓, BAX↑, Casp3↑, Casp7↑, Casp8↑, p‑HER2/EBBR2↓, HO-1↑, NRF2↑, BIM↑, p‑FOXO3↓, Sp1/3/4↓, cMyc↓, EGFR↓, survivin↓, cMET↓, NQO1↑, SOD2↑, TrxR↓, MDM2↓, p‑eIF2α↑, ATF4↑, CHOP/DDIT3↑, MDA↑, Ki-67↓, MMP9↓, Twist↓, SOX2↓, Nanog↓, OCT4↓, N-cadherin↓, Vim↓, Snail↓, TumW↓, TumCG↓, HK2↓, RB1↓, IL6↓, IL8↓, SOD1↑, RadioS↑, ChemoSen↑, toxicity↓, Sp1/3/4↓, GSH↓, SOD↑,
1940- PL,    Piperlongumine Inhibits Migration of Glioblastoma Cells via Activation of ROS-Dependent p38 and JNK Signaling Pathways
- in-vitro, GBM, LN229 - in-vitro, GBM, U87MG
ROS↑, GSH↓, p38↑, JNK↑, IKKα↑, NF-kB↓, eff↓,
3341- QC,    Antioxidant Activities of Quercetin and Its Complexes for Medicinal Application
- Review, Var, NA - Review, Stroke, NA
*antiOx↑, *BioAv↑, *GSH↑, *AChE↓, *BChE↓, *H2O2↓, *lipid-P↓, *SOD↑, *SOD2↑, *Catalase↑, *GPx↑, *neuroP↑, *HO-1↑, *cardioP↑, *MDA↓, *NF-kB↓, *IKKα↓, *ROS↓, *PI3K↑, *Akt↑, *hepatoP↑, P53↑, BAX↑, IGF-1R↓, Akt↓, AR↓, TumCP↓, GSH↑, SOD↑, Catalase↑, lipid-P↓, *TNF-α↓, *Ca+2↓,
48- QC,    Quercetin Potentiates Apoptosis by Inhibiting Nuclear Factor-kappaB Signaling in H460 Lung Cancer Cells
- in-vitro, NSCLC, H460
TRAILR↑, Casp10↑, DFF45↑, TNFR 1↑, Fas↑, NF-kB↓, IKKα↓,
923- QC,    Quercetin as an innovative therapeutic tool for cancer chemoprevention: Molecular mechanisms and implications in human health
- Review, Var, NA
ROS↑, GSH↓, Ca+2↝, MMP↓, Casp3↑, Casp8↑, Casp9↑, other↓, *ROS↓, *NRF2↑, HO-1↑, TumCCA↑, Inflam↓, STAT3↓, DR5↑, P450↓, MMPs↓, IFN-γ↓, IL6↓, COX2/PTGS2↓, IL8↓, iNOS↓, TNF-α↓, cl‑PARP↑, Apoptosis↑, P53↑, Sp1/3/4↓, survivin↓, TRAILR↑, Casp10↑, DFF45↑, TNFR 1↑, Fas↑, NF-kB↓, IKKα↓, cycD1/CCND1↓, Bcl-2↓, BAX↑, PI3K↓, Akt↓, E-cadherin↓, Vim↓, β-catenin/ZEB1↓, cMyc↓, EMT↓, MMP2↓, NOTCH1↓, MMP7↓, angioG↓, TSP-1↑, CSCs↓, XIAP↓, Snail↓, Slug↓, LEF1↓, P-gp/ABCB1↓, EGFR↓, GSK‐3β↓, mTOR↓, RAGE↓, HSP27↓, VEGF↓, TGF-β↓, COL1↓, COL3A1↓,
5140- SAS,    Suppression of NF-κB activity by sulfasalazine is mediated by direct inhibition of IκB kinases α and β
- in-vitro, AML, Jurkat - in-vitro, CRC, SW-620
TNF-α↓, IKKα↓, NF-kB↓,
3189- SFN,    Sulforaphane Inhibits TNF-α-Induced Adhesion Molecule Expression Through the Rho A/ROCK/NF-κB Signaling Pathway
- in-vitro, Nor, ECV304
*ICAM-1↓, *IL1β↓, *IL6↓, *IL8↓, *p‑IKKα↓, *Rho↓, *ROCK1↓, *ERK↓, *Inflam↓,
1726- SFN,    Sulforaphane: A Broccoli Bioactive Phytocompound with Cancer Preventive Potential
- Review, Var, NA
Dose↝, eff↝, IL1β↓, IL6↓, IL12↓, TNF-α↓, COX2/PTGS2↓, CXCR4↓, MPO↓, HSP70/HSPA5↓, HSP90↓, VCAM-1↓, IKKα↓, NF-kB↓, HO-1↑, Casp3↑, Casp7↑, Casp8↑, Casp9↑, cl‑PARP↑, Cyt‑c↑, Diablo↑, CHOP/DDIT3↑, survivin↓, XIAP↓, p38↑, Fas↑, PUMA↑, VEGF↓, Hif1a↓, Twist↓, Zeb1↓, Vim↓, MMP2↓, MMP9↓, E-cadherin↑, N-cadherin↓, Snail↓, CD44↓, cycD1/CCND1↓, cycA1/CCNA1↓, CycB/CCNB1↓, cycE/CCNE↓, CDK4↓, CDK6↓, p50↓, P53↑, P21↑, GSH↑, SOD↑, GSTs↑, mTOR↓, Akt↓, PI3K↓, β-catenin/ZEB1↓, IGF-1↓, cMyc↓, CSCs↓,
2209- SK,    Shikonin inhibits tumor invasion via down-regulation of NF-κB-mediated MMP-9 expression in human ACC-M cells
- in-vitro, adrenal, ACC-M
MMP9↓, NF-kB↓, IKKα↓,
3042- SK,    The protective effects of Shikonin on lipopolysaccharide/D -galactosamine-induced acute liver injury via inhibiting MAPK and NF-kB and activating Nrf2/HO-1 signaling pathways
- in-vivo, Nor, NA
*TNF-α↓, *IL1β↓, *IL6↓, *IFN-γ↓, *ALAT↓, *AST↓, *MPO↓, *ROS↓, *JNK↓, *ERK↓, *p38↓, *NF-kB↓, *p‑IKKα↓, *SOD↑, *GSH↑, *HO-1↑, *NRF2↑, *hepatoP↑,
1195- SM,    Salvia miltiorrhiza polysaccharide activates T Lymphocytes of cancer patients through activation of TLRs mediated -MAPK and -NF-κB signaling pathways
- in-vitro, Lung, A549 - in-vitro, Liver, HepG2 - in-vitro, CRC, HCT116
T-Cell↑, TumCP∅, IL4↑, IL6↑, IFN-γ↑, TLR4↑, TLR1↑, TLR2↑, p‑JNK↑, p‑ERK↑, IKKα↑,
1817- VitK2,    Research progress on the anticancer effects of vitamin K2
- Review, Var, NA
TumCCA↑, Apoptosis↑, TumAuto↑, TumCI↓, TumCG↓, ChemoSen↓, ChemoSideEff↓, toxicity∅, Synergy↑, cycD1/CCND1↓, CDK4↓, eff↑, IKKα↓, NF-kB↓, other↑, p27/CDKN1B↑, cMyc↓, i-ROS↑, Bcl-2↓, BAX↑, p38↑, MMP↓, Casp9↑, p‑ERK↓, RAS↓, MAPK↓, p‑P53↑, Casp8↑, Casp3↑, cJun↑, MMPs↓, Synergy↑, Synergy↑,

Showing Research Papers: 51 to 63 of 63
Prev Page 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 63

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

Catalase↓, 1,   Catalase↑, 1,   GPx↓, 1,   GPx1↓, 1,   GSH↓, 6,   GSH↑, 2,   GSR↓, 1,   GSTs↓, 1,   GSTs↑, 1,   H2O2↑, 2,   HO-1↓, 2,   HO-1↑, 3,   lipid-P?, 1,   lipid-P↓, 1,   lipid-P↑, 1,   MDA↑, 1,   MPO↓, 1,   NQO1↓, 1,   NQO1↑, 1,   NRF2↓, 2,   NRF2↑, 2,   ROS↑, 12,   i-ROS↑, 1,   SOD↓, 1,   SOD↑, 3,   SOD1↑, 1,   SOD2↓, 3,   SOD2↑, 1,   TrxR↓, 1,   VitC↓, 1,   VitE↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Tf↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

OXPHOS↓, 1,   SIRT3↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,   AMP↓, 1,   AMPK↑, 2,   Glycolysis↓, 1,   GSK‐3β↓, 2,   GSK‐3β↑, 1,   p‑GSK‐3β↓, 1,   HK2↓, 1,   LDHA↓, 1,   MCT4↓, 1,   PKM2↓, 1,   p‑S6↓, 1,   SIRT1↓, 1,  

Cell Death(tgid=5) ⓘ

AIF↑, 1,   Apoptosis↓, 1,   Apoptosis↑, 16,   ASC↓, 1,   BAD↑, 2,   BAX↑, 13,   Bax:Bcl2↑, 2,   Bcl-2↓, 13,   Bcl-2↑, 1,   Bcl-xL↓, 10,   BID↓, 1,   BIM↑, 1,   Casp↑, 2,   Casp1↓, 1,   Casp10↑, 2,   Casp2↑, 1,   Casp3↑, 12,   cl‑Casp3↑, 1,   Casp7↑, 2,   cl‑Casp7↑, 1,   Casp8↑, 9,   Casp9↑, 8,   cl‑Casp9↑, 1,   cFLIP↓, 3,   Cyt‑c↑, 6,   Diablo↑, 1,   DR5↑, 5,   FADD↑, 1,   Fas↑, 5,   FasL↑, 2,   FasL⇅, 1,   iNOS↓, 1,   Mcl-1↓, 2,   Mcl-1↑, 1,   MDM2↓, 2,   MDM2↑, 1,   p‑MDM2↓, 1,   NOXA↑, 1,   p38↑, 4,   p‑p38↑, 2,   p‑p38↝, 1,   Paraptosis↑, 1,   PUMA↑, 2,   survivin↓, 12,   TNFR 1↓, 1,   TNFR 1↑, 2,   TRAILR↑, 2,   TumCD↑, 2,   XIAP↓, 5,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 11,   Akt↑, 1,   p‑Akt↓, 4,   CaMKII ↓, 1,   cMET↓, 1,   p‑cMET↑, 1,   EF-1α↓, 1,   EGFR↓, 5,   EGFR↑, 1,   p‑EGFR↓, 1,   ERK↓, 7,   ERK↑, 1,   p‑ERK↓, 3,   p‑ERK↑, 1,   p‑ERK↝, 1,   HER2/EBBR2↓, 1,   p‑HER2/EBBR2↓, 1,   HGF/c-Met↓, 1,   IGF-1R↓, 1,   IGFR↓, 1,   IKKα↓, 36,   IKKα↑, 9,   IKKα↝, 1,   p‑IKKα↓, 8,   IκB↓, 1,   JAK1↓, 1,   JAK2↓, 1,   JNK↑, 3,   p‑JNK↑, 3,   p‑JNK↝, 1,   MAPK↓, 6,   p‑MAPK↓, 1,   p‑MEK↓, 1,   mTOR↓, 8,   p‑mTOR↓, 2,   NIK↓, 1,   p‑P70S6K↓, 1,   p‑P90RSK↑, 1,   p‑PDGFR-BB↓, 1,   PI3K↓, 9,   p‑PI3K↓, 1,   PI3K/Akt↓, 2,   PTEN↓, 1,   PTEN↑, 2,   c-Raf↓, 1,   RAS↓, 1,   RAS↑, 1,   Sp1/3/4↓, 3,   p‑Src↓, 1,   STAT3↓, 7,   p‑STAT3↓, 2,   p‑STAT6↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF3↑, 1,   ATF4↑, 1,   cJun↓, 2,   cJun↑, 2,   p‑cJun↑, 1,   cMyc↓, 8,   p‑FOXO3↓, 1,   H3↓, 1,   H3↑, 1,   H4↓, 1,   H4↑, 1,   HATs↑, 1,   HDAC↓, 3,   HDAC10↓, 1,   miR-200b↑, 1,   Myc↓, 1,   OCT4↓, 2,   other↓, 1,   other↑, 1,   SOX2↓, 2,   SOX4↓, 1,   tumCV↓, 5,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 5,   cl‑CHOP/DDIT3↑, 1,   eIF2α↑, 1,   p‑eIF2α↑, 2,   ER Stress↑, 4,   GRP78/BiP↑, 3,   p‑Hsc70↑, 1,   HSP27↓, 1,   HSP70/HSPA5↓, 1,   HSP90↓, 2,   IRE1↑, 1,   p‑PERK↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 1,   ATG7↑, 1,   LC3II↑, 2,   TumAuto↑, 2,  

DNA Damage & Repair(tgid=10) ⓘ

DFF45↑, 2,   DNAdam↑, 3,   P53↑, 12,   p‑P53↑, 1,   PARP↑, 1,   cl‑PARP↑, 8,   PARP1↑, 1,   PCNA↓, 4,   TOP1↓, 1,   TOP2↓, 1,   TOP2↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 2,   CDK2↓, 4,   CDK4↓, 7,   CDK6↓, 2,   cycA1/CCNA1↓, 3,   cycA1/CCNA1↑, 1,   CycB/CCNB1↓, 4,   cycD1/CCND1↓, 11,   cycE/CCNE↓, 3,   E2Fs↓, 1,   Ki-67↓, 2,   P21?, 1,   P21↑, 5,   p27/CDKN1B↑, 3,   RB1↓, 1,   p‑RB1↓, 2,   TumCCA↓, 1,   TumCCA↑, 11,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMPs↑, 1,   CD133↓, 2,   CD24↓, 1,   CD34↓, 1,   cFos↓, 2,   cFos↑, 1,   CSCs↓, 4,   Gli1↓, 1,   HH↓, 1,   IGF-1↓, 2,   Ki-67↓, 2,   Let-7↑, 1,   mTORC1↓, 2,   Nanog↓, 2,   Nestin↓, 2,   NOTCH1↓, 3,   NOTCH3↓, 1,   PTCH1↓, 1,   Shh↓, 2,   Sufu↓, 1,   TumCG↓, 12,   TumCP↓, 14,   TumCP∅, 1,   Wnt↓, 2,   Wnt/(β-catenin)↓, 1,   ZFX↓, 1,  

Migration(tgid=13) ⓘ

AP-1↓, 1,   AXL↓, 1,   Ca+2↑, 1,   Ca+2↝, 1,   Cdc42↓, 1,   COL1↓, 1,   COL3A1↓, 1,   E-cadherin↓, 2,   E-cadherin↑, 2,   EFEMP↓, 1,   EMT↓, 9,   FAK↓, 1,   ITGB1↓, 1,   LEF1↓, 1,   MET↓, 1,   p‑MET↓, 1,   MMP1↓, 1,   MMP2↓, 12,   MMP7↓, 1,   MMP9↓, 13,   MMPs↓, 7,   N-cadherin↓, 5,   PDGF↓, 2,   Rac1↓, 1,   Rho↓, 1,   ROCK1↓, 1,   Slug↓, 2,   p‑SMAD2↓, 1,   p‑SMAD3↓, 1,   Snail↓, 6,   SPARC↓, 1,   TGF-β↓, 2,   TIMP1↓, 1,   TIMP2↓, 1,   TIMP2↑, 3,   TSP-1↑, 1,   TumCI↓, 13,   TumCMig↓, 9,   TumMeta↓, 7,   Twist↓, 3,   Tyro3↓, 1,   uPA↓, 3,   uPAR↓, 1,   Vim↓, 4,   Vim↑, 1,   Zeb1↓, 2,   α-SMA↓, 1,   β-catenin/ZEB1↓, 6,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 7,   CD31/PECAM-1↓, 1,   HIF-1↓, 1,   Hif1a↓, 6,   VCAM-1↓, 1,   VEGF↓, 17,   VEGFR1↓, 1,   VEGFR2/KDR/Flk1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

CLDN1↓, 1,   EPR↑, 1,   GLUT1↓, 1,   MMP↓, 6,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD44↓, 1,   COX2/PTGS2↓, 9,   CXCc↓, 1,   CXCR2↓, 1,   CXCR4↓, 5,   DR4↑, 2,   GM-CSF↓, 2,   ICAM-1↓, 2,   IFN-γ↓, 1,   IFN-γ↑, 1,   IL1↓, 1,   IL12↓, 1,   IL1α↓, 2,   IL1β↓, 3,   IL2↓, 1,   IL2↑, 1,   IL4↑, 1,   IL6↓, 7,   IL6↑, 1,   IL8↓, 3,   Inflam↓, 3,   MCP1/CCL2↓, 1,   MDSCs↓, 1,   MIP2↓, 1,   MyD88↓, 1,   NF-kB↓, 40,   NF-kB↑, 2,   NF-kB↝, 1,   p‑NF-kB↓, 1,   NLRP3↓, 2,   p50↓, 1,   p65↓, 5,   p‑p65↓, 3,   PD-1↓, 1,   PD-L1↓, 1,   PGE2↓, 3,   RAGE↓, 1,   T-Cell↑, 1,   TIRAP↓, 1,   TLR1↑, 1,   TLR2↑, 1,   TLR4↓, 2,   TLR4↑, 1,   TNF-α↓, 5,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,  

Protein Aggregation(tgid=19) ⓘ

APP↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 3,   PPARα↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 1,   BioAv↓, 3,   BioAv↑, 4,   ChemoSen↓, 1,   ChemoSen↑, 7,   CYP1A1↓, 1,   CYP1A1↑, 1,   Dose↑, 1,   Dose↝, 2,   eff↓, 5,   eff↑, 3,   eff↝, 3,   Half-Life↓, 2,   Half-Life↝, 1,   MRP1/ABCC1↓, 1,   P-gp/ABCB1↓, 3,   P450↓, 1,   RadioS↑, 2,   selectivity↑, 5,   Synergy↑, 9,  

Clinical Biomarkers(tgid=22) ⓘ

AR↓, 3,   ascitic↓, 1,   CEA↓, 1,   EGFR↓, 5,   EGFR↑, 1,   p‑EGFR↓, 1,   HER2/EBBR2↓, 1,   p‑HER2/EBBR2↓, 1,   IL6↓, 7,   IL6↑, 1,   Myc↓, 1,   NSE↓, 1,   PD-L1↓, 1,   RAGE↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,   AntiTum↑, 1,   cachexia↓, 1,   cardioP↑, 1,   chemoP↑, 2,   chemoPv↑, 3,   ChemoSideEff↓, 1,   memory↑, 1,   OS↑, 1,   Risk↓, 1,   toxicity↓, 3,   toxicity∅, 1,   TumVol↓, 3,   TumW↓, 2,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 1,  
Total Targets: 400

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 4,   Catalase↑, 3,   GPx↑, 3,   GSH↑, 6,   GSR↑, 1,   GSSG↓, 1,   GSTs↑, 1,   H2O2↓, 1,   HO-1↑, 4,   lipid-P↓, 3,   MDA↓, 2,   MPO↓, 1,   NRF2↑, 4,   ROS↓, 8,   ROS∅, 2,   SOD↑, 4,   SOD2↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 3,   AMPK↑, 1,   HK2↓, 1,   LDL↓, 1,   lipidLev↓, 1,   NADPH↓, 1,   PKM2↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 1,   Casp3↓, 2,   cl‑Casp3↓, 1,   iNOS↓, 1,   p38↓, 1,   p‑p38↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↑, 1,   Akt2↓, 1,   ERK↓, 3,   p‑ERK↓, 1,   IKKα↓, 5,   IKKα↑, 1,   p‑IKKα↓, 4,   p‑IκB↓, 1,   JNK↓, 1,   p‑JNK↓, 1,   MAPK↓, 2,   MAPK↑, 1,   PI3K↑, 1,   RKIP↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

cl‑PARP1↓, 1,  

Migration(tgid=13) ⓘ

ARG1/2↑, 1,   Ca+2↓, 1,   Ca+2↝, 1,   MLC2/MYL9↝, 1,   p‑Rac1↓, 1,   Rho↓, 1,   ROCK1↓, 1,   TGF-β1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

E-sel↓, 2,   NO↓, 2,   VCAM-1↓, 3,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   OCLN↝, 1,   TJ↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD25+↓, 1,   CD69↓, 1,   COX1↓, 1,   COX2/PTGS2↓, 3,   CTLA-4↓, 1,   ICAM-1↓, 3,   IFN-γ↓, 3,   IL1↓, 1,   IL10↓, 1,   IL10↑, 4,   IL12↓, 1,   IL17↓, 2,   IL1β↓, 4,   IL2↓, 2,   IL4↓, 1,   IL4↑, 1,   IL6↓, 5,   IL8↓, 2,   Inflam?, 1,   Inflam↓, 6,   MCP1/CCL2↓, 1,   MyD88↓, 1,   NF-kB↓, 9,   NLRP3↓, 2,   p‑p65↓, 1,   PGE2↓, 2,   TLR4↓, 1,   TNF-α↓, 8,   TNF-α↑, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 1,   BChE↓, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 2,   Dose↝, 1,   eff↑, 1,   Half-Life↝, 1,   P-gp/ABCB1↓, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 3,   ALP↓, 1,   AST↓, 3,   CRP↓, 1,   hs-CRP↓, 1,   IL6↓, 5,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 1,   antiAll↑, 1,   AntiArt↑, 1,   AntiCan↑, 1,   AntiDiabetic↑, 1,   cardioP↑, 3,   cognitive↑, 2,   hepatoP↑, 6,   memory↑, 1,   neuroP↑, 5,   RenoP↑, 1,   toxicity↑, 1,   toxicity↝, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiViral↑, 1,   GutMicro↑, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 4,  
Total Targets: 120

Scientific Paper Hit Count for: IKKα, IκB kinase alpha)
4 Ashwagandha(Withaferin A)
4 Deguelin
3 Apigenin (mainly Parsley)
3 Baicalein
3 Berbamine
3 Honokiol
3 Nimbolide
3 Sulforaphane (mainly Broccoli)
3 Piperlongumine
3 Quercetin
2 Betulinic acid
2 Curcumin
2 Magnetic Fields
2 Shikonin
1 Alpha-Lipoic-Acid
1 Berberine
1 Boswellia (frankincense)
1 Chlorophyllin
1 Crocetin
1 Diclofenac
1 Emodin
1 Eurycomanone
1 Fenbendazole
1 Fisetin
1 Flaxseed/Linseed
1 Genistein (soy isoflavone)
1 Ginger/6-Shogaol/Gingerol
1 Luteolin
1 Matrine
1 Methyl salicylate / Sweet Birch oil
1 Metformin
1 Magnetic Field Rotating
1 Mangiferin
1 Phenethyl isothiocyanate
1 Phycocyanin
1 Piperine
1 Sulfasalazine
1 Salvia miltiorrhiza
1 Vitamin K2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:156  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

Home Page