IL6 Cancer Research Results

IL6, Interleukin-6: Click to Expand ⟱
Source: HalifaxProj(inhibit)
Type:
Interleukin-6 (IL-6) is a cytokine that plays a significant role in inflammation and the immune response. It is produced by various cell types, including T cells, B cells, macrophages, and fibroblasts.
IL-6 can promote tumor cell proliferation and survival. Many cancer cells produce IL-6, which can create an autocrine loop that supports their growth.
IL-6 is a high-value inflammatory biomarker in cancer, reporting cytokine burden, catabolic stress, and STAT3-linked survival signaling. While not tumor-specific, elevated and rising IL-6 strongly predicts poor prognosis and limited treatment tolerance, making it an important system-state indicator alongside CRP and ferritin.


Scientific Papers found: Click to Expand⟱
5553- BBM,    A review on berbamine–a potential anticancer drug
- Review, Var, NA
P-gp↓, MDR1↓, survivin↓, NF-kB↓, TumCP↓, TumCCA↑, Apoptosis↑, SMAD3↑, P21↑, cycD1/CCND1↓, cMyc↑, Bcl-2↓, Bcl-xL↓, BAX↑, CaMKII ↓, ChemoSen↑, MMP2↓, MMP9↓, TIMP1↑, cl‑Casp3↑, cl‑Casp9↑, cl‑Casp8↑, cl‑PARP↑, IL6↓, ROS↑,
2713- BBR,    Berberine improved the microbiota in lung tissue of colon cancer and reversed the bronchial epithelial cell changes caused by cancer cells
- in-vitro, Nor, BEAS-2B
*GutMicro↑, *IL6↑, *IL10↑, *IL17↑, *IFN-γ↑, PDGF↓, *RAD51↓,
2674- BBR,    Berberine: A novel therapeutic strategy for cancer
- Review, Var, NA - Review, IBD, NA
Inflam↓, AntiCan↑, Apoptosis↑, TumAuto↑, TumCCA↑, TumMeta↓, TumCI↓, eff↑, eff↑, CD4+↓, TNF-α↓, IL1↓, BioAv↓, BioAv↓, other↓, AMPK↑, MAPK↓, NF-kB↓, IL6↓, MCP1↓, PGE2↓, COX2↓, *ROS↓, *antiOx↑, *GPx↑, *Catalase↑, AntiTum↑, TumCP↓, angioG↓, Fas↑, FasL↑, ROS↑, ATM↑, P53↑, RB1↑, Casp9↑, Casp8↑, Casp3↓, BAX↑, Bcl-2↓, Bcl-xL↓, IAP1↓, XIAP↓, survivin↓, MMP2↓, MMP9↓, CycB/CCNB1↓, CDC25↓, CDC25↓, Cyt‑c↑, MMP↓, RenoP↑, mTOR↓, MDM2↓, LC3II↑, ERK↓, COX2↓, MMP3↓, TGF-β↓, EMT↑, ROCK1↓, FAK↓, RAS↓, Rho↓, NF-kB↓, uPA↓, MMP1↓, MMP13↓, ChemoSen↑,
2677- BBR,    Liposome-Encapsulated Berberine Alleviates Liver Injury in Type 2 Diabetes via Promoting AMPK/mTOR-Mediated Autophagy and Reducing ER Stress: Morphometric and Immunohistochemical Scoring
- in-vivo, Diabetic, NA
*hepatoP↑, *LC3II↑, *Beclin-1↑, *AMPK↑, *mTOR↑, *ER Stress↓, *CHOP↓, *JNK↓, *ROS↓, *Inflam↓, *BG↓, *SOD↑, *GPx↑, *Catalase↑, *IL10↑, *IL6↓, *TNF-α↓, *ALAT↓, *AST↓, *ALP↓,
2686- BBR,    Effects of resveratrol, curcumin, berberine and other nutraceuticals on aging, cancer development, cancer stem cells and microRNAs
- Review, Nor, NA
Inflam↓, IL6↓, MCP1↓, COX2↓, PGE2↓, MMP2↓, MMP9↓, DNAdam↑, eff↝, Telomerase↓, Bcl-2↓, AMPK↑, ROS↑, MMP↓, ATP↓, p‑mTORC1↓, p‑S6K↓, ERK↓, PI3K↓, PTEN↑, Akt↓, Raf↓, MEK↓, Dose↓, Dose↑, selectivity↑, TumCCA↑, eff↑, EGFR↓, Glycolysis↓, Dose?, p27↑, CDK2↓, CDK4↓, cycD1/CCND1↓, cycE/CCNE↓, Bax:Bcl2↑, Casp3↑, Casp9↑, VEGFR2↓, ChemoSen↑, eff↑, eff↑, PGE2↓, JAK2↓, STAT3↓, CXCR4↓, CCR7↓, uPA↓, CSCs↓, EMT↓, Diff↓, CD133↓, Nestin↓, n-MYC↓, NOTCH↓, SOX2↓, Hif1a↓, VEGF↓, RadioS↑,
1092- BBR,    Berberine as a Potential Anticancer Agent: A Comprehensive Review
- Review, NA, NA
Apoptosis↑, TumCCA↑, TumAuto↑, TumCI↓, IL1↓, IL6↓, TNF-α↓, LDH↓, P2X7↓, proCasp1↓, Casp1↓, ASC↓,
4274- BBR,    Berberine exerts antidepressant effects in vivo and in vitro through the PI3K/AKT/CREB/BDNF signaling pathway
- in-vivo, NA, NA
*IL1β↓, *IL6↓, *TNF-α↓, *CRP↓, *CREB↑, *BDNF↑,
5631- BCA,    Perspectives Regarding the Role of Biochanin A in Humans
- Review, Var, NA - Review, AD, NA
*BioAv↓, *Inflam↓, AntiCan↑, *neuroP↑, chemoPv↑, Dose↝, *SOD↑, *MDA↓, *BAX↓, *HSP70/HSPA5↑, *AntiDiabetic↑, *Insulin↑, *TNF-α↓, *IL1β↓, *IL6↓, *iNOS↓, *COX2↓, *MMP9↓, *ROS↓, *PGE2↓, *BACE↓, *BioAv↑, P-gp⇅,
2725- BetA,    Betulinic acid protects against renal damage by attenuation of oxidative stress and inflammation via Nrf2 signaling pathway in T-2 toxin-induced mice
- in-vivo, Nor, NA
*RenoP↑, *SOD?, *Catalase↑, *GSH↑, *ROS↓, *MDA↓, *IL1β↓, *TNF-α↓, *IL10↓, *IL6↑, *NRF2↑,
2749- BetA,    Anti-Inflammatory Activities of Betulinic Acid: A Review
- Review, Nor, NA
Inflam↓, *NO↓, *IL10↑, *ICAM-1↓, *VCAM-1↓, *E-sel↓, *NF-kB↓, *IKKα↓, *COX2↓, *PGE2↓, *IL1β↓, *IL6↓, *IL8↓, *IL12↓, *TNF-α↑, *HO-1↑, *IL10↑, *IL2↓, *IL17↓, *IFN-γ↓, *SOD↑, *GPx↑, *GSR↑, *MDA↓, *MAPK↓,
5483- BM,    The Role of Bacopa monnieri in Alzheimer’s Disease: Mechanisms and Potential Clinical Use—A Review
- Review, AD, NA
*cognitive↑, *neuroP↑, *PI3K↑, *Akt↑, *GSK‐3β↓, *tau↓, *ROS↓, *MMP3↓, *Casp1↓, *Casp3↓, *NF-kB↓, *TNF-α↓, *IL6↓,
5656- BNL,    Role of borneol as enhancer in drug formulation: A review
- Review, Nor, NA - Review, Stroke, NA - Review, AD, NA
*eff↑, BBB↑, ChemoSen↑, *Inflam↓, *NO↓, *TNF-α↓, *IL6↓, *Bacteria↓, *eff↑, *Aβ↓, *SOD↑, *neuroP↑, *EPR↑, toxicity↓, P-gp↓, eff↑, other↝,
5653- BNL,    Borneol hinders the proliferation and induces apoptosis through the suppression of reactive oxygen species-mediated JAK1 and STAT-3 signaling in human prostate cancer cells
- in-vitro, Pca, PC3
ROS↑, TumCP↓, cycD1/CCND1↓, cycE1↓, Apoptosis↑, BAX↓, Casp3↑, Bcl-2↓, IL6↓, JAK1↓, STAT3↓,
3517- Bor,  Se,    The protective effects of selenium and boron on cyclophosphamide-induced hepatic oxidative stress, inflammation, and apoptosis in rats
- in-vivo, Nor, NA
*hepatoP↑, *ALAT↓, *AST↓, *ALP↓, *NF-kB↓, *TNF-α↓, *IL1β↓, *IL6↓, *IL10↑, *SOD↑, *Catalase↑, *MDA↓, *GSH↑, *GPx↑, *antiOx↑, *NRF2↑, *Keap1↓,
3516- Bor,    Boron in wound healing: a comprehensive investigation of its diverse mechanisms
- Review, Wounds, NA
*Inflam↓, *antiOx↑, *ROS↓, *angioG↑, *COL1↑, *α-SMA↑, *TGF-β↑, *BMD↑, *hepatoP↑, *TNF-α↑, *HSP70/HSPA5↑, *SOD↑, *Catalase↑, *GSH↑, *MDA↓, *TOS↓, *IL6↓, *JAK2↓, *STAT3↓, *AMPK↑, *lipid-P↓, *VEGF↑, *Half-Life↝,
3520- Bor,    Effect of boron element on photoaging in rats
- in-vivo, NA, NA
*hepatoP↑, *BMD↑, *COX2↓, *IL8↓, *NF-kB↓, *IL6↓, *TNF-α↓,
699- Bor,    Boric Acid Alleviates Gastric Ulcer by Regulating Oxidative Stress and Inflammation-Related Multiple Signaling Pathways
- in-vivo, NA, NA
*ROS↓, *MDA↓, *TNF-α↓, *IL6↓, *JAK2↓, *STAT3↓, *AMPK↑, *Sema3A/PlexinA1↑,
743- Bor,    Boric Acid (Boron) Attenuates AOM-Induced Colorectal Cancer in Rats by Augmentation of Apoptotic and Antioxidant Mechanisms
- in-vitro, CRC, NA
BAX↑, Bcl-2↓, GPx↑, SOD↑, Catalase↑, MDA↓, TNF-α↓, IL6↓, IL10↑,
726- Bor,    Redox Mechanisms Underlying the Cytostatic Effects of Boric Acid on Cancer Cells—An Issue Still Open
- Review, NA, NA
NAD↝, SAM-e↝, PSA↓, IGF-1↓, Cyc↓, P21↓, p‑MEK↓, p‑ERK↓, ROS↑, SOD↓, Catalase↓, MDA↑, GSH↓, IL1↓, IL6↓, TNF-α↓, BRAF↝, MAPK↝, PTEN↝, PI3K/Akt↝, eIF2α↑, ATF4↑, ATF6↑, NRF2↑, BAX↑, BID↑, Casp3↑, Casp9↑, Bcl-2↓, Bcl-xL↓,
2776- Bos,    Anti-inflammatory and anti-cancer activities of frankincense: Targets, treatments and toxicities
- Review, Var, NA
*5LO↓, *TNF-α↓, *MMP3↓, *COX1↓, *COX2↓, *PGE2↓, *Th2↑, *Catalase↑, *SOD↑, *NO↑, *PGE2↑, *IL1β↓, *IL6↓, *Th1 response↓, *Th2↑, *iNOS↓, *NO↓, *p‑JNK↓, *p38↓, GutMicro↑, p‑Akt↓, GSK‐3β↓, cycD1/CCND1↓, Akt↓, STAT3↓, CSCs↓, AR↓, P21↑, DR5↑, CHOP↑, Casp3↑, Casp8↑, cl‑PARP↑, DNAdam↑, p‑RB1↓, FOXM1↓, TOP2↓, CDC25↓, p‑CDK1↓, p‑ERK↓, MMP9↓, VEGF↓, angioG↓, ROS↑, Cyt‑c↑, AIF↑, Diablo↑, survivin↓, ICAD↓, ChemoSen↑, SOX9↓, ER Stress↑, GRP78/BiP↑, cal2↓, AMPK↓, mTOR↓, ROS↓,
2775- Bos,    The journey of boswellic acids from synthesis to pharmacological activities
- Review, Var, NA - Review, AD, NA - Review, PSA, NA
ROS↑, ER Stress↑, TumCG↓, Apoptosis↑, Inflam↓, ChemoSen↑, Casp↑, ERK↓, cl‑PARP↑, AR↓, cycD1/CCND1↓, VEGFR2↓, CXCR4↓, radioP↑, NF-kB↓, VEGF↓, P21↑, Wnt↓, β-catenin/ZEB1↓, Cyt‑c↑, MMP2↓, MMP1↓, MMP9↓, PI3K↓, MAPK↓, JNK↑, *5LO↓, *NRF2↑, *HO-1↑, *MDA↓, *SOD↑, *hepatoP↑, *ALAT↓, *AST↓, *LDH↑, *CRP↓, *COX2↓, *GSH↑, *ROS↓, *Imm↑, *Dose↝, *eff↑, *neuroP↑, *cognitive↑, *IL6↓, *TNF-α↓,
2768- Bos,    Boswellic acids as promising agents for the management of brain diseases
- Review, Var, NA - Review, AD, NA - Review, Park, NA
*neuroP↑, *ROS↓, *cognitive↓, TumCP↓, TumCMig↓, TumMeta↓, angioG↓, Apoptosis↑, *Inflam↓, IL1↓, IL2↓, IL4↓, IL6↓, TNF-α↓, P53↑, Akt↓, NF-kB↓, DNAdam↑, Casp↑, COX2↓, MMP9↓, CXCR4↓, VEGF↓, *SOD↑, *Catalase↑, *GPx↑, *NRF2↑,
2772- Bos,    Mechanistic role of boswellic acids in Alzheimer’s disease: Emphasis on anti-inflammatory properties
- Review, AD, NA
*neuroP↑, *Inflam↓, *AChE↓, *Choline↑, *NRF2↑, *NF-kB↑, *BBB↑, *BioAv↑, *Half-Life↓, *Dose↝, *PGE2↓, *ROS↓, *cognitive↑, *antiOx↑, 5LO↓, *TNF-α↓, *IL6↓, *HO-1↑,
5705- Brut,    A flavonoid-rich extract from bergamot juice prevents carcinogenesis in a genetic model of colorectal cancer, the Pirc rat (F344/NTac-Apcam1137)
- in-vivo, CRC, NA
Risk↓, TumMeta↓, Apoptosis↑, COX2↓, iNOS↓, IL1β↓, IL6↓, IL10↓, P53↑, P21↓, survivin↓, chemoPv↑, *Inflam↓,
5742- Buty,    Butyrate: A Double-Edged Sword for Health?
- Review, Var, NA
HCAR2↑, Inflam↓, HDAC↓, *IFN-γ↓, *TNF-α↓, *IL1β↓, *IL6↓, *IL8↓, *IL10↑, *TNF-β↑, *NF-kB↓, *ROS↓, PPARγ↓, Weight↓,
5740- Buty,    A Review of Nutritional Regulation of Intestinal Butyrate Synthesis: Interactions Between Dietary Polysaccharides and Proteins
- Review, RCC, NA
*eff↓, Dose↝, eff↑, HDAC↓, ac‑H3↓, ac‑H4↓, *HCAR2↑, *Inflam↓, *ROS↓, *NRF2↑, *GSH↑, *CLDN1↑, *ZO-1↑, IL1β↓, IL6↓, COX2↓, eff↝, eff↑, other↝,
5739- Buty,    Butyrate as a promising therapeutic target in cancer: From pathogenesis to clinic (Review)
- Review, Var, NA
GutMicro↑, *Inflam↓, *IL6↓, *TNF-α↓, *IL17↓, *IL10↑, *ROS↝, COX2↓, NLRP3↓, Imm↑, HDAC↓, TumCCA↑, Apoptosis↑, ROS↑, Casp↑, mtDam↑, Cyt‑c↑, eff↑, chemoP↑, ChemoSen↑, eff↑, RadioS↑, HCAR2↑,
1011- CA,    Dihydrocaffeic acid improves IL-1β-induced inflammation and cartilage degradation via inhibiting NF-κB and MAPK signalling pathways
- in-vivo, NA, NA
iNOS↓, IL6↓, SOX9↑, NF-kB↓, MAPK↓,
1652- CA,    Caffeic Acid and Diseases—Mechanisms of Action
- Review, Var, NA
Dose∅, ROS⇅, NF-kB↓, STAT3↓, VEGF↓, MMP9↓, HSP70/HSPA5↑, AST↝, ALAT↝, ALP↝, Hif1a↓, IL6↓, IGF-1R↓, P21↑, iNOS↓, ERK↓, Snail↓, BID↑, BAX↑, Casp3↑, Casp7↑, Casp9↑, cycD1/CCND1↓, Vim↓, β-catenin/ZEB1↓, COX2↓, ROS↑,
3854- CAP,    Capsaicin consumption reduces brain amyloid-beta generation and attenuates Alzheimer’s disease-type pathology and cognitive deficits in APP/PS1 mice
- in-vivo, AD, NA
*Aβ↓, *cognitive↑, *APP↓, *MMP-10↝, *p‑tau↓, *Inflam↓, *neuroP↑, *Risk↓, *TNF-α↓, *IFN-γ↓, *IL6↓, *PPARα↑,
3869- Carno,    Carnosine, Small but Mighty—Prospect of Use as Functional Ingredient for Functional Food Formulation
- Review, AD, NA - Review, Stroke, NA
*ROS↓, *IronCh↑, *AntiAge↑, *antiOx↑, *Inflam↓, *neuroP↑, *lipid-P↓, *toxicity↓, *NOX4↓, *SOD↑, *HNE↓, *IL6↓, *TNF-α↓, *IL1β↓, *Sepsis↓, *eff↑, *GABA↝, *Aβ↓, Glycolysis↓, AntiTum↑, p‑Akt↓, TumCCA↑, angioG↓, VEGFR2↓, NF-kB↓,
2393- Cela,    Celastrol mitigates inflammation in sepsis by inhibiting the PKM2-dependent Warburg effect
- in-vivo, Sepsis, NA - in-vitro, Nor, RAW264.7
OS↑, PKM2↓, Glycolysis↓, Warburg↓, Inflam↓, HMGB1↓, ALAT↓, AST↓, TNF-α↓, IL1β↓, IL6↓,
2392- Cela,    The role of natural products targeting macrophage polarization in sepsis-induced lung injury
- Review, Sepsis, NA
TNF-α↓, IL1β↓, IL6↓, Warburg↓, PKM2↓, NRF2↑, HO-1↑, NF-kB↓, iNOS↓, M1↓,
2782- CHr,    Broad-Spectrum Preclinical Antitumor Activity of Chrysin: Current Trends and Future Perspectives
- Review, Var, NA - Review, Stroke, NA - Review, Park, NA
*antiOx↑, *Inflam↓, *hepatoP↑, *neuroP↑, *BioAv↓, *cardioP↑, *lipidLev↓, *RenoP↑, *TNF-α↓, *IL2↓, *PI3K↓, *Akt↓, *ROS↓, *cognitive↑, eff↑, cycD1/CCND1↓, hTERT/TERT↓, VEGF↓, p‑STAT3↓, TumMeta↓, TumCP↓, eff↑, eff↑, IL1β↓, IL6↓, NF-kB↓, ROS↑, MMP↓, Cyt‑c↑, Apoptosis↑, ER Stress↑, Ca+2↑, TET1↑, Let-7↑, Twist↓, EMT↓, TumCCA↑, Casp3↑, Casp9↑, BAX↑, HK2↓, GlucoseCon↓, lactateProd↓, Glycolysis↓, SHP1↑, N-cadherin↓, E-cadherin↑, UPR↑, PERK↑, ATF4↑, eIF2α↑, RadioS↑, NOTCH1↑, NRF2↓, BioAv↑, eff↑,
2785- CHr,    Emerging cellular and molecular mechanisms underlying anticancer indications of chrysin
- Review, Var, NA
*NF-kB↓, *COX2↓, *iNOS↓, angioG↓, TOP1↓, HDAC↓, TNF-α↓, IL1β↓, cardioP↑, RenoP↑, neuroP↑, LDL↓, BioAv↑, eff↑, cycD1/CCND1↓, hTERT/TERT↓, MMP-10↓, Akt↓, STAT3↓, VEGF↓, EGFR↓, Snail↓, Slug↓, Vim↓, E-cadherin↑, eff↑, TET1↑, ROS↑, mTOR↓, PPARα↓, ER Stress↑, Ca+2↑, ERK↓, MMP↑, Cyt‑c↑, Casp3↑, HK2↓, NRF2↓, HO-1↓, MMP2↓, MMP9↓, Fibronectin↓, GRP78/BiP↑, XBP-1↓, p‑eIF2α↑, *AST↓, ALAT↓, ALP↓, LDH↓, COX2↑, Bcl-xL↓, IL6↓, PGE2↓, iNOS↓, DNAdam↑, UPR↑, Hif1a↓, EMT↓, Twist↓, lipid-P↑, CLDN1↓, PDK1↓, IL10↓, TLR4↓, NOTCH1↑, PARP↑, Mcl-1↓, XIAP↓,
4257- CoQ10,    Dietary intake of coenzyme Q10 reduces oxidative stress in patients with acute ischemic stroke: a double-blind, randomized placebo-controlled study
- Trial, Stroke, NA
*MDA↓, *IL6↓, *SOD↑, *BDNF↑, *ROS↓, *Inflam↓, *neuroP↑,
3994- CoQ10,  Se,    Coenzyme Q10 Supplementation in Aging and Disease
- Review, AD, NA - Review, Park, NA
*AntiAge↑, *cardioP↑, *Inflam↓, *antiOx↑, *lipid-P↓, *QoL↑, *neuroP↑, *Dose↝, *BP↓, *IGF-1↑, *IGFBP1↑, *eff↑, *LDL↓, *HDL↑, *eff↑, *other↑, *RenoP↑, *ROS↓, *TNF-α↓, *IL6↓, *other↝, *other∅,
1809- CUR,  Oxy,    Long-term stabilisation of myeloma with curcumin
- Case Report, Melanoma, NA
*OS↑, QoL↑, Dose↑, Dose↑, IL6↓, STAT3↓, NF-kB↓, COX2↓,
1418- CUR,    Potential complementary and/or synergistic effects of curcumin and boswellic acids for management of osteoarthritis
- Review, Arthritis, NA
*COX2↓, *Inflam↓, *5LO↓, *NO↓, *NF-kB↓, *TNF-α↓, *IL1↓, *IL2↑, *IL6↓, *IL8↓, *IL12↓, *MCP1↓, *PGE2↓, *MMP2↓, *MMP3↓, *MMP9↓, *NLRP3↓, *ROS↓,
140- CUR,    Curcumin inhibits cancer-associated fibroblast-driven prostate cancer invasion through MAOA/mTOR/HIF-1α signaling
- in-vitro, Pca, PC3
CAFs/TAFs↓, EMT↓, ROS↓, CXCR4↓, IL6↓, MAOA↓, mTOR↓, HIF-1↓,
15- CUR,  UA,    Effects of curcumin and ursolic acid in prostate cancer: A systematic review
- Review, Pca, NA
NF-kB↝, Akt↝, AR↝, Apoptosis↝, Bcl-2↝, Casp3↝, BAX↝, P21↝, ROS↝, Bcl-xL↝, JNK↝, MMP2↝, P53↝, PSA↝, VEGF↝, COX2↝, cycD1/CCND1↝, EGFR↝, IL6↝, β-catenin/ZEB1↝, mTOR↝, NRF2↝, AP-1↝, Cyt‑c↝, PI3K↝, PTEN↝, Cyc↝, TNF-α↝,
13- CUR,    Role of curcumin in regulating p53 in breast cancer: an overview of the mechanism of action
- Review, BC, NA
P53↑, DR5↑, JNK↑, NRF2↑, PPARγ↑, HER2/EBBR2↓, IR↓, ER(estro)↓, Fas↑, PDGF↓, TGF-β↓, FGF↓, EGFR↓, JAK↓, PAK↓, MAPK↓, ATPase↓, COX2↓, MMPs↓, IL1↓, IL2↓, IL5↓, IL6↓, IL8↓, IL12↓, IL18↓, NF-kB↓, NOTCH1↓, STAT1↓, STAT4↓, STAT5↓, STAT3↓,
465- CUR,    Curcumin inhibits the growth of liver cancer by impairing myeloid-derived suppressor cells in murine tumor tissues
- vitro+vivo, Liver, HepG2 - vitro+vivo, Liver, HUH7 - vitro+vivo, Liver, MHCC-97H
TumCG↓, MDSCs↓, TLR4↓, NF-kB↓, IL6↓, IL1↓, PGE2↓, COX2↓, GM-CSF↓, angioG↓, VEGF↓, CD31↓, GM-CSF↓, α-SMA↓, p‑IKKα↓, MyD88↓,
2688- CUR,    Effects of resveratrol, curcumin, berberine and other nutraceuticals on aging, cancer development, cancer stem cells and microRNAs
- Review, Var, NA - Review, AD, NA
*ROS↓, *SOD↑, p16↑, JAK2↓, STAT3↓, CXCL12↓, IL6↓, MMP2↓, MMP9↓, TGF-β↓, α-SMA↓, LAMs↓, DNAdam↑, *memory↑, *cognitive↑, *Inflam↓, *antiOx↑, *NO↑, *MDA↓, *ROS↓, DNMT1↓, ROS↑, Casp3↑, Apoptosis↑, miR-21↓, LC3II↓, ChemoSen↑, NF-kB↓, CSCs↓, Nanog↓, OCT4↓, SOX2↓, eff↑, Sp1/3/4↓, miR-27a-3p↓, ZBTB10↑, SOX9?, ChemoSen↑, VEGF↓, XIAP↓, Bcl-2↓, cycD1/CCND1↓, BioAv↑, Hif1a↓, EMT↓, BioAv↓, PTEN↑, VEGF↓, Akt↑, EZH2↓, NOTCH1↓, TP53↑, NQO1↑, HO-1↑,
2818- CUR,    Novel Insight to Neuroprotective Potential of Curcumin: A Mechanistic Review of Possible Involvement of Mitochondrial Biogenesis and PI3/Akt/ GSK3 or PI3/Akt/CREB/BDNF Signaling Pathways
- Review, AD, NA
*neuroP↑, *ROS↓, *Inflam↓, *Apoptosis↓, *cognitive↑, *cardioP↑, other↑, *COX2↓, *IL1β↓, *TNF-α↓, NF-kB↓, *PGE2↓, *iNOS↓, *NO↓, *IL2↓, *IL4↓, *IL6↓, *INF-γ↓, *GSK‐3β↓, *STAT↓, *GSH↑, *MDA↓, *lipid-P↓, *SOD↑, *GPx↑, *Catalase↑, *GSR↓, *LDH↓, *H2O2↓, *Casp3↓, *Casp9↓, *NRF2↑, *AIF↓, *ATP↑,
4650- CUR,    Curcumin and cancer stem cells: curcumin has asymmetrical effects on cancer and normal stem cells
- Review, Var, NA
SCD1↓, IL6↓, IL8↓, IL1↓, *selectivity↑, Wnt↝, NOTCH↝, HH↝, FAK↝,
3794- CUR,    Curcumin hybrid molecules for the treatment of Alzheimer's disease: Structure and pharmacological activities
- Review, AD, NA
*GSK‐3β↓, *CDK5↓, *p‑tau↓, *IronCh↑, *ROS↓, *HO-1↑, *SOD↑, *Catalase↑, *GSH↑, *TNF-α↓, *IL6↓, *IL12↓, *NRF2↑, *PPARγ↑, *IL4↑, *AChE↓, *Dose↝, *GutMicro↑,
3588- CUR,    The effect of curcumin on cognition in Alzheimer’s disease and healthy aging: A systematic review of pre-clinical and clinical studies
- Review, AD, NA
*cognitive↝, *BioAv↑, *Inflam↓, *COX2↓, *iNOS↓, *NF-kB↓, *TNF-α↓, *IL1↓, *IL2↓, *IL6↓, *IL8↓, *IL12↓, *ROS↓, *RNS↓, *antiOx↑, *BBB↑, *BioAv↓, *cognitive↑, *memory↑, *tau↓, *eff↑,
3582- CUR,  PI,    Therapeutic and Preventive Effects of Piperine and its Combination with Curcumin as a Bioenhancer Against Aluminum-Induced Damage in the Astrocyte Cells
*eff↑, *IL6↓, *TGF-β↓, *BioAv↑,
1085- DHA,  EPA,    DHA and EPA Down-regulate COX-2 Expression through Suppression of NF-kappaB Activity in LPS-treated Human Umbilical Vein Endothelial Cells
- in-vitro, Nor, HUVECs
*COX2↓, *NF-kB↓, *PGE2↓, *IL6↓, *NF-kB↑,

Showing Research Papers: 51 to 100 of 277
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 277

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

Catalase↓, 1,   Catalase↑, 1,   GPx↑, 1,   GSH↓, 1,   HO-1↓, 1,   HO-1↑, 2,   lipid-P↑, 1,   MDA↓, 1,   MDA↑, 1,   NQO1↑, 1,   NRF2↓, 2,   NRF2↑, 3,   NRF2↝, 1,   ROS↓, 2,   ROS↑, 12,   ROS⇅, 1,   ROS↝, 1,   SAM-e↝, 1,   SOD↓, 1,   SOD↑, 1,  

Mitochondria & Bioenergetics ⓘ

AIF↑, 1,   ATP↓, 1,   CDC25↓, 3,   MEK↓, 1,   p‑MEK↓, 1,   MMP↓, 3,   MMP↑, 1,   mtDam↑, 1,   Raf↓, 1,   XIAP↓, 3,  

Core Metabolism/Glycolysis ⓘ

ALAT↓, 2,   ALAT↝, 1,   AMPK↓, 1,   AMPK↑, 2,   cMyc↑, 1,   GlucoseCon↓, 1,   Glycolysis↓, 4,   HK2↓, 2,   IR↓, 1,   lactateProd↓, 1,   LDH↓, 2,   LDL↓, 1,   NAD↝, 1,   PDK1↓, 1,   PI3K/Akt↝, 1,   PKM2↓, 2,   PPARα↓, 1,   PPARγ↓, 1,   PPARγ↑, 1,   p‑S6K↓, 1,   SCD1↓, 1,   Warburg↓, 2,  

Cell Death ⓘ

Akt↓, 4,   Akt↑, 1,   Akt↝, 1,   p‑Akt↓, 2,   Apoptosis↑, 10,   Apoptosis↝, 1,   BAX↓, 1,   BAX↑, 6,   BAX↝, 1,   Bax:Bcl2↑, 1,   Bcl-2↓, 7,   Bcl-2↝, 1,   Bcl-xL↓, 4,   Bcl-xL↝, 1,   BID↑, 2,   Casp↑, 3,   Casp1↓, 1,   proCasp1↓, 1,   Casp3↓, 1,   Casp3↑, 8,   Casp3↝, 1,   cl‑Casp3↑, 1,   Casp7↑, 1,   Casp8↑, 2,   cl‑Casp8↑, 1,   Casp9↑, 5,   cl‑Casp9↑, 1,   Cyt‑c↑, 6,   Cyt‑c↝, 1,   Diablo↑, 1,   DR5↑, 2,   Fas↑, 2,   FasL↑, 1,   hTERT/TERT↓, 2,   IAP1↓, 1,   ICAD↓, 1,   iNOS↓, 5,   JNK↑, 2,   JNK↝, 1,   MAPK↓, 4,   MAPK↝, 1,   Mcl-1↓, 1,   MDM2↓, 1,   p27↑, 1,   P2X7↓, 1,   survivin↓, 4,   Telomerase↓, 1,  

Kinase & Signal Transduction ⓘ

CaMKII ↓, 1,   HCAR2↑, 2,   HER2/EBBR2↓, 1,   PAK↓, 1,   SOX9?, 1,   SOX9↓, 1,   SOX9↑, 1,   Sp1/3/4↓, 1,  

Transcription & Epigenetics ⓘ

EZH2↓, 1,   ac‑H3↓, 1,   ac‑H4↓, 1,   miR-21↓, 1,   miR-27a-3p↓, 1,   other↓, 1,   other↑, 1,   other↝, 2,  

Protein Folding & ER Stress ⓘ

ATF6↑, 1,   CHOP↑, 1,   eIF2α↑, 2,   p‑eIF2α↑, 1,   ER Stress↑, 4,   GRP78/BiP↑, 2,   HSP70/HSPA5↑, 1,   PERK↑, 1,   UPR↑, 2,   XBP-1↓, 1,  

Autophagy & Lysosomes ⓘ

LC3II↓, 1,   LC3II↑, 1,   TumAuto↑, 2,  

DNA Damage & Repair ⓘ

ATM↑, 1,   DNAdam↑, 5,   DNMT1↓, 1,   p16↑, 1,   P53↑, 4,   P53↝, 1,   PARP↑, 1,   cl‑PARP↑, 3,   TP53↑, 1,  

Cell Cycle & Senescence ⓘ

p‑CDK1↓, 1,   CDK2↓, 1,   CDK4↓, 1,   Cyc↓, 1,   Cyc↝, 1,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 9,   cycD1/CCND1↝, 1,   cycE/CCNE↓, 1,   cycE1↓, 1,   P21↓, 2,   P21↑, 4,   P21↝, 1,   RB1↑, 1,   p‑RB1↓, 1,   TumCCA↑, 7,  

Proliferation, Differentiation & Cell State ⓘ

BRAF↝, 1,   CD133↓, 1,   CSCs↓, 3,   Diff↓, 1,   EMT↓, 5,   EMT↑, 1,   ERK↓, 5,   p‑ERK↓, 2,   FGF↓, 1,   FOXM1↓, 1,   GSK‐3β↓, 1,   HDAC↓, 4,   HH↝, 1,   IGF-1↓, 1,   IGF-1R↓, 1,   Let-7↑, 1,   mTOR↓, 4,   mTOR↝, 1,   p‑mTORC1↓, 1,   n-MYC↓, 1,   Nanog↓, 1,   Nestin↓, 1,   NOTCH↓, 1,   NOTCH↝, 1,   NOTCH1↓, 2,   NOTCH1↑, 2,   OCT4↓, 1,   PI3K↓, 2,   PI3K↝, 1,   PTEN↑, 2,   PTEN↝, 2,   RAS↓, 1,   SHP1↑, 1,   SOX2↓, 2,   STAT1↓, 1,   STAT3↓, 8,   p‑STAT3↓, 1,   STAT4↓, 1,   STAT5↓, 1,   TOP1↓, 1,   TOP2↓, 1,   TumCG↓, 2,   Wnt↓, 1,   Wnt↝, 1,  

Migration ⓘ

5LO↓, 1,   AP-1↝, 1,   ATPase↓, 1,   Ca+2↑, 2,   CAFs/TAFs↓, 1,   cal2↓, 1,   CD31↓, 1,   CLDN1↓, 1,   CXCL12↓, 1,   E-cadherin↑, 2,   FAK↓, 1,   FAK↝, 1,   Fibronectin↓, 1,   LAMs↓, 1,   MMP-10↓, 1,   MMP1↓, 2,   MMP13↓, 1,   MMP2↓, 6,   MMP2↝, 1,   MMP3↓, 1,   MMP9↓, 9,   MMPs↓, 1,   N-cadherin↓, 1,   PDGF↓, 2,   Rho↓, 1,   ROCK1↓, 1,   Slug↓, 1,   SMAD3↑, 1,   Snail↓, 2,   TET1↑, 2,   TGF-β↓, 3,   TIMP1↑, 1,   TumCI↓, 2,   TumCMig↓, 1,   TumCP↓, 5,   TumMeta↓, 4,   Twist↓, 2,   uPA↓, 2,   Vim↓, 2,   α-SMA↓, 2,   β-catenin/ZEB1↓, 2,   β-catenin/ZEB1↝, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 6,   ATF4↑, 2,   EGFR↓, 3,   EGFR↝, 1,   HIF-1↓, 1,   Hif1a↓, 4,   VEGF↓, 10,   VEGF↝, 1,   VEGFR2↓, 3,   ZBTB10↑, 1,  

Barriers & Transport ⓘ

BBB↑, 1,   P-gp↓, 2,   P-gp⇅, 1,  

Immune & Inflammatory Signaling ⓘ

ASC↓, 1,   CCR7↓, 1,   CD4+↓, 1,   COX2↓, 11,   COX2↑, 1,   COX2↝, 1,   CXCR4↓, 4,   GM-CSF↓, 2,   HCAR2↑, 2,   HMGB1↓, 1,   p‑IKKα↓, 1,   IL1↓, 7,   IL10↓, 2,   IL10↑, 1,   IL12↓, 1,   IL18↓, 1,   IL1β↓, 6,   IL2↓, 2,   IL4↓, 1,   IL5↓, 1,   IL6↓, 22,   IL6↝, 1,   IL8↓, 2,   Imm↑, 1,   Inflam↓, 6,   JAK↓, 1,   JAK1↓, 1,   JAK2↓, 2,   M1↓, 1,   MCP1↓, 2,   MDSCs↓, 1,   MyD88↓, 1,   NF-kB↓, 15,   NF-kB↝, 1,   PGE2↓, 5,   PSA↓, 1,   PSA↝, 1,   TLR4↓, 2,   TNF-α↓, 8,   TNF-α↝, 1,  

Synaptic & Neurotransmission ⓘ

MAOA↓, 1,  

Protein Aggregation ⓘ

NLRP3↓, 1,  

Hormonal & Nuclear Receptors ⓘ

AR↓, 2,   AR↝, 1,   ER(estro)↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 3,   BioAv↑, 3,   ChemoSen↑, 9,   Dose?, 1,   Dose↓, 1,   Dose↑, 3,   Dose↝, 2,   Dose∅, 1,   eff↑, 17,   eff↝, 2,   MDR1↓, 1,   RadioS↑, 3,   selectivity↑, 1,  

Clinical Biomarkers ⓘ

ALAT↓, 2,   ALAT↝, 1,   ALP↓, 1,   ALP↝, 1,   AR↓, 2,   AR↝, 1,   AST↓, 1,   AST↝, 1,   BRAF↝, 1,   EGFR↓, 3,   EGFR↝, 1,   EZH2↓, 1,   FOXM1↓, 1,   GutMicro↑, 2,   HER2/EBBR2↓, 1,   hTERT/TERT↓, 2,   IL6↓, 22,   IL6↝, 1,   LDH↓, 2,   PSA↓, 1,   PSA↝, 1,   TP53↑, 1,  

Functional Outcomes ⓘ

AntiCan↑, 2,   AntiTum↑, 2,   cardioP↑, 1,   chemoP↑, 1,   chemoPv↑, 2,   neuroP↑, 1,   OS↑, 1,   QoL↑, 1,   radioP↑, 1,   RenoP↑, 2,   Risk↓, 1,   toxicity↓, 1,   Weight↓, 1,  
Total Targets: 345

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 9,   Catalase↑, 9,   GPx↑, 6,   GSH↑, 7,   GSR↓, 1,   GSR↑, 1,   H2O2↓, 1,   HDL↑, 1,   HNE↓, 1,   HO-1↑, 4,   Keap1↓, 1,   lipid-P↓, 4,   MDA↓, 10,   NOX4↓, 1,   NRF2↑, 8,   RNS↓, 1,   ROS↓, 22,   ROS↝, 1,   SOD?, 1,   SOD↑, 14,   TOS↓, 1,  

Metal & Cofactor Biology ⓘ

IronCh↑, 2,  

Mitochondria & Bioenergetics ⓘ

AIF↓, 1,   ATP↑, 1,   Insulin↑, 1,  

Core Metabolism/Glycolysis ⓘ

ALAT↓, 3,   AMPK↑, 3,   CREB↑, 1,   LDH↓, 1,   LDH↑, 1,   LDL↓, 1,   lipidLev↓, 1,   PPARα↑, 1,   PPARγ↑, 1,  

Cell Death ⓘ

Akt↓, 1,   Akt↑, 1,   Apoptosis↓, 1,   BAX↓, 1,   Casp1↓, 1,   Casp3↓, 2,   Casp9↓, 1,   iNOS↓, 5,   JNK↓, 1,   p‑JNK↓, 1,   MAPK↓, 1,   p38↓, 1,  

Kinase & Signal Transduction ⓘ

HCAR2↑, 1,  

Transcription & Epigenetics ⓘ

other↑, 1,   other↝, 1,   other∅, 1,  

Protein Folding & ER Stress ⓘ

CHOP↓, 1,   ER Stress↓, 1,   HSP70/HSPA5↑, 2,  

Autophagy & Lysosomes ⓘ

Beclin-1↑, 1,   LC3II↑, 1,  

DNA Damage & Repair ⓘ

RAD51↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

Choline↑, 1,   GSK‐3β↓, 3,   IGF-1↑, 1,   IGFBP1↑, 1,   mTOR↑, 1,   PI3K↓, 1,   PI3K↑, 1,   STAT↓, 1,   STAT3↓, 2,  

Migration ⓘ

5LO↓, 3,   APP↓, 1,   CDK5↓, 1,   CLDN1↑, 1,   COL1↑, 1,   E-sel↓, 1,   MMP-10↝, 1,   MMP2↓, 1,   MMP3↓, 3,   MMP9↓, 2,   Sema3A/PlexinA1↑, 1,   TGF-β↓, 1,   TGF-β↑, 1,   VCAM-1↓, 1,   ZO-1↑, 1,   α-SMA↑, 1,  

Angiogenesis & Vasculature ⓘ

angioG↑, 1,   EPR↑, 1,   NO↓, 5,   NO↑, 2,   VEGF↑, 1,  

Barriers & Transport ⓘ

BBB↑, 2,  

Immune & Inflammatory Signaling ⓘ

COX1↓, 1,   COX2↓, 10,   CRP↓, 2,   HCAR2↑, 1,   ICAM-1↓, 1,   IFN-γ↓, 3,   IFN-γ↑, 1,   IKKα↓, 1,   IL1↓, 2,   IL10↓, 1,   IL10↑, 7,   IL12↓, 4,   IL17↓, 2,   IL17↑, 1,   IL1β↓, 9,   IL2↓, 4,   IL2↑, 1,   IL4↓, 1,   IL4↑, 1,   IL6↓, 25,   IL6↑, 2,   IL8↓, 5,   Imm↑, 1,   INF-γ↓, 1,   Inflam↓, 18,   JAK2↓, 2,   MCP1↓, 1,   NF-kB↓, 9,   NF-kB↑, 2,   PGE2↓, 7,   PGE2↑, 1,   Th1 response↓, 1,   Th2↑, 2,   TNF-α↓, 22,   TNF-α↑, 2,   TNF-β↑, 1,  

Synaptic & Neurotransmission ⓘ

AChE↓, 2,   BDNF↑, 2,   GABA↝, 1,   tau↓, 2,   p‑tau↓, 2,  

Protein Aggregation ⓘ

Aβ↓, 3,   BACE↓, 1,   NLRP3↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 3,   BioAv↑, 4,   Dose↝, 4,   eff↓, 1,   eff↑, 8,   Half-Life↓, 1,   Half-Life↝, 1,   selectivity↑, 1,  

Clinical Biomarkers ⓘ

ALAT↓, 3,   ALP↓, 2,   AST↓, 4,   BG↓, 1,   BMD↑, 2,   BP↓, 1,   CRP↓, 2,   GutMicro↑, 2,   IL6↓, 25,   IL6↑, 2,   LDH↓, 1,   LDH↑, 1,  

Functional Outcomes ⓘ

AntiAge↑, 2,   AntiDiabetic↑, 1,   cardioP↑, 3,   cognitive↓, 1,   cognitive↑, 8,   cognitive↝, 1,   hepatoP↑, 6,   memory↑, 2,   neuroP↑, 12,   OS↑, 1,   QoL↑, 1,   RenoP↑, 3,   Risk↓, 1,   toxicity↓, 1,  

Infection & Microbiome ⓘ

Bacteria↓, 1,   Sepsis↓, 1,  
Total Targets: 167

Scientific Paper Hit Count for: IL6, Interleukin-6
15 Quercetin
13 Curcumin
13 Hydrogen Gas
12 Lycopene
12 Sulforaphane (mainly Broccoli)
9 Magnetic Fields
8 Propolis -bee glue
8 Resveratrol
8 Silymarin (Milk Thistle) silibinin
8 Shikonin
8 Thymoquinone
7 Baicalein
7 EGCG (Epigallocatechin Gallate)
6 Artemisinin
6 Berberine
6 Boron
6 Rosmarinic acid
6 Urolithin
5 Alpha-Lipoic-Acid
5 Ashwagandha(Withaferin A)
5 Luteolin
4 Silver-NanoParticles
4 Cisplatin
4 Boswellia (frankincense)
4 Piperine
4 Piperlongumine
4 Vitamin C (Ascorbic Acid)
3 Allicin (mainly Garlic)
3 Apigenin (mainly Parsley)
3 Melatonin
3 Butyrate
3 Ellagic acid
3 Fisetin
3 Honokiol
3 Magnetic Field Rotating
3 Pterostilbene
3 Selenite (Sodium)
2 Auranofin
2 Astragalus
2 Ascorbyl Palmitate
2 Astaxanthin
2 Aloe anthraquinones
2 beta-glucans
2 Baicalin
2 Betulinic acid
2 borneol
2 Selenium
2 Caffeic acid
2 Celastrol
2 Chrysin
2 Coenzyme Q10
2 Ursolic acid
2 Paclitaxel
2 Chemotherapy
2 Rutin
2 Selenium NanoParticles
1 2-DeoxyGlucose
1 alpha Linolenic acid
1 Andrographis
1 Atorvastatin
1 immunotherapy
1 Berbamine
1 Biochanin A
1 Bacopa monnieri
1 Bruteridin(bergamot juice)
1 Capsaicin
1 Carnosine
1 Oxygen, Hyperbaric
1 Docosahexaenoic Acid
1 eicosapentaenoic acid
1 diet Short Term Fasting
1 Radiotherapy/Radiation
1 Electrical Pulses
1 Exercise
1 Ferulic acid
1 Garcinol
1 Ginseng
1 γ-linolenic acid (Borage Oil)
1 HydroxyCitric Acid
1 Orlistat
1 Juglone
1 Potassium
1 5-fluorouracil
1 Methylsulfonylmethane
1 Naringin
1 Niclosamide (Niclocide)
1 Oleuropein
1 probiotics
1 Bifidobacterium
1 Phosphatidylserine
1 Perilla
1 Docetaxel
1 Salvia miltiorrhiza
1 Aflavin-3,3′-digallate
1 Vitamin B12
1 Folic Acid, Vit B9
1 Vitamin B3,Niacin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:158  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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