iNOS Cancer Research Results

iNOS, Inducible nitric oxide synthase: Click to Expand ⟱
Source: HalifaxProj(block)
Type:
An enzyme that produces nitric oxide (NO) in response to inflammatory stimuli.
iNOS can promote tumor growth by enhancing blood flow and nutrient supply to tumors through vasodilation. It may also help cancer cells evade apoptosis (programmed cell death).
Immune Activation: In some contexts, NO produced by iNOS can enhance the immune response against tumors, promoting the activation of immune cells that can target and destroy cancer cells.
Inhibition of Tumor Growth: High levels of NO can induce cytotoxic effects on tumor cells, leading to reduced proliferation and increased apoptosis.
Scientific Papers found: Click to Expand⟱
3275- Lyco,    Multifaceted Effects of Lycopene: A Boulevard to the Multitarget-Based Treatment for Cancer
- Review, Var, NA
TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, P21↑, P53↑, GSK‐3β↓, p27↓, Akt↓, mTOR↓, ROS↓, MMPs↓, TumCI↓, TumCMig↓, NF-kB↓, *iNOS↓, *COX2↓, lipid-P↓, GSH↑, NRF2↑,
3278- Lyco,    Anti-inflammatory effect of lycopene in SW480 human colorectal cancer cells
- in-vitro, Colon, SW480
TNF-α↓, IL1β↓, IL6↓, iNOS↓, COX2↓, PGE2↓, NO↓, NF-kB↓, JNK↓, Inflam↓, MPO↓,
4782- Lyco,    New Insights into Molecular Mechanism behind Anti-Cancer Activities of Lycopene
- Review, Var, NA
AntiCan↑, TumCP↓, TumCMig↓, TumCI↓, TumCA↓, ROS↓, MMP2↓, MMP7↓, MMP9↓, VEGF↓, E-cadherin↑, TIMP1↑, TIMP2↑, BioAv↝, *IL12↓, *TNF-α↓, *IL1↓, *IL1β↓, *IL6↓, COX2↓, iNOS↓, *radioP↑, NF-kB↓, survivin↓, Casp3↑, Bax:Bcl2↑,
1089- MAG,    Magnolol potently suppressed lipopolysaccharide-induced iNOS and COX-2 expression via downregulating MAPK and NF-κB signaling pathways
- in-vitro, AML, RAW264.7
p‑IκB↓, NF-kB↓, p‑ERK↓, p‑JNK↓, p‑PI3K↓, p‑Akt↓, iNOS↓, COX2↓,
5252- MAG,    Insights on the Multifunctional Activities of Magnolol
- Review, Var, NA
BioAv↓, *Inflam↓, *Bacteria↓, *antiOx↑, *neuroP↑, *cardioP↑, CYP1A1↓, *PPARγ↑, *NF-kB↓, *COX2↓, *iNOS↓, *ROS↓, Apoptosis↑, TumCCA↑, cycD1/CCND1↓, cycA1/CCNA1↓, CDK2↓, P21↑, TumCG↓, TumCMig↓, TumCI↓, Ki-67↓, PCNA↓, MMP2↓, MMP9↓, MMP7↓, DNAdam↑, MMP↓, TumCP↓, selectivity↑, PI3K↓, Akt↓, H2O2↓, Hif1a↓, *BDNF↑, *NRF2↑, *AChE↑,
1777- MEL,    Melatonin as an antioxidant: under promises but over delivers
- Review, NA, NA
*ROS↓, *Fenton↓, *antiOx↑, *toxicity∅, *GPx↑, *GSR↑, *GSH↑, *NO↓, *Iron↓, *Copper↓, *IL1β↓, *iNOS↓, *Casp3↓, *BBB↑, *RenoP↑, chemoP↑, *Ca+2↝, eff↑, *PKCδ?, ChemoSen↑, eff↑, Akt↓, DR5↑, selectivity↑, ROS↑, eff↑,
2253- MF,    Low-frequency pulsed electromagnetic field promotes functional recovery, reduces inflammation and oxidative stress, and enhances HSP70 expression following spinal cord injury
- in-vivo, Nor, NA
*Inflam↓, *TNF-α↓, *IL1β↓, *NF-kB↓, *iNOS↓, *ROS↓, Catalase↑, *SOD↑, *HSP70/HSPA5↑, *neuroP↑, *motorD↑, *antiOx↑,
4116- MF,    Low‑frequency pulsed electromagnetic field promotes functional recovery, reduces inflammation and oxidative stress, and enhances HSP70 expression following spinal cord injury
- in-vivo, NA, NA
*Inflam↓, *TNF-α↓, *IL1β↓, *iNOS↓, *ROS↓, *Catalase↑, *SOD↑, HSP70/HSPA5↑,
3468- MF,    An integrative review of pulsed electromagnetic field therapy (PEMF) and wound healing
- Review, NA, NA
*other↑, *necrosis↓, *IL6↑, *TGF-β↑, *iNOS↑, *MMP2↑, *MCP1↑, *HO-1↑, *Inflam↓, *IL1β↓, *IL6↓, *TNF-α↓, *BioAv↑, eff⇅, DNAdam↑, Apoptosis↑, ROS↑, TumCP↓, *ROS↓, *FGF↑,
204- MFrot,  MF,    Rotating magnetic field improved cognitive and memory impairments in a sporadic ad model of mice by regulating microglial polarization
- in-vivo, AD, NA
*NF-kB↓, *MAPK↓, *TLR4↓, *memory↑, *cognitive↑, *TGF-β1↑, *ARG↑, *IL4↑, *IL10↑, *IL6↓, *IL1↓, *TNF-α↓, *iNOS↓, *ROS↓, *NO↓, *MyD88↓, *p‑IKKα↓, *p‑IκB↓, *p‑p65↓, *p‑JNK↓, *p‑p38↓, *ERK↓, *neuroP↑, *Aβ↓,
3847- MSM,    Methylsulfonylmethane: Applications and Safety of a Novel Dietary Supplement
- Review, Arthritis, NA
*Inflam↓, *Pain↓, *ROS↓, *antiOx↑, *Dose↝, *Half-Life↝, *NF-kB↓, *IL1↓, *IL6↓, *TNF-α↓, *iNOS↓, *COX2↓, *NLRP3↓, *NRF2↑, *STAT↓, *Cartilage↑, *eff↑, *eff↑, *GSH↑, *uricA↓, tumCV↓, TumCCA↑, necrosis↑, Apoptosis↑, VEGF↓, HSP90↓, IGF-1?,
4647- OLEC,    Oleocanthal, an Antioxidant Phenolic Compound in Extra Virgin Olive Oil (EVOO): A Comprehensive Systematic Review of Its Potential in Inflammation and Cancer
- Review, Var, NA
*Inflam↓, AntiCan↑, *COX2↓, *ROS↓, *TNF-α↓, *IL1β↓, *iNOS↓, TumCP↓, *AntiAg↑, mTOR↓, STAT3↓, ERK↓, p‑Akt↓, Bcl-2↓, ROS↑, PSA↓,
2035- PB,    Sodium Phenylbutyrate Controls Neuroinflammatory and Antioxidant Activities and Protects Dopaminergic Neurons in Mouse Models of Parkinson’s Disease
- in-vitro, Nor, glial - in-vivo, NA, NA
*ROS↓, *Inflam↑, *P21↓, *antiOx↑, *GSH↑, *NF-kB↓, *neuroP↑, *HDAC↓, *iNOS↓, *TNF-α↓, *IL1β↓, *LDL↓, ROS↓,
3249- PBG,    Can Propolis Be a Useful Adjuvant in Brain and Neurological Disorders and Injuries? A Systematic Scoping Review of the Latest Experimental Evidence
- Review, Var, NA
*Inflam↓, *ROS↓, *MDA↓, *TNF-α↓, *NO↓, *iNOS↓, *SOD↑, *GPx↑, *GSR↓, *GSH↑, *neuroP↑, *IL6↓, *MMP2↓, *MMP9↓, *MCP1↓, *HSP70/HSPA5↑, *motorD↑, *Pain↓, *VCAM-1↓, *NF-kB↓, *MAPK↓, *JNK↓, *IL1β↓, *AChE↓, *toxicity∅, cognitive↑,
1680- PBG,    Protection against Ultraviolet A-Induced Skin Apoptosis and Carcinogenesis through the Oxidative Stress Reduction Effects of N-(4-bromophenethyl) Caffeamide, a Propolis Derivative
- in-vitro, Nor, HS68
*ROS↓, *NRF2↑, *HO-1↑, *cJun↓, *MMP1↓, *MMP2↓, *p‑cJun↓, *cFos↓, *BAX↓, *Casp3↓, *DNAdam↓, *iNOS↓, *COX2↓, *IL6↓, *PGE2↓, *NO↓,
1672- PBG,    The Potential Use of Propolis as an Adjunctive Therapy in Breast Cancers
- Review, BC, NA
ChemoSen↓, RadioS↑, Inflam↓, AntiCan↑, Dose∅, mtDam↑, Apoptosis?, OCR↓, ATP↓, ROS↑, ROS↑, LDH↓, TP53↓, Casp3↓, BAX↓, P21↓, ROS↑, eNOS↑, iNOS↑, eff↑, hTERT/TERT↓, cycD1/CCND1↓, eff↑, eff↑, eff↑, eff↑, STAT3↓, TIMP1↓, IL4↓, IL10↓, OS↑, Dose∅, ER Stress↑, ROS↑, NF-kB↓, p65↓, MMP↓, TumAuto↑, LC3II↑, p62↓, TLR4↓, mtDam↑, LDH↓, ROS↑, Glycolysis↓, HK2↓, PFK↓, PKM2↓, LDH↓, IL10↓, HDAC8↓, eff↑, eff↑, P21↑,
1682- PBG,    Honey, Propolis, and Royal Jelly: A Comprehensive Review of Their Biological Actions and Health Benefits
- Review, Var, NA
i-LDH↓, Akt↓, MAPK↓, NF-kB↓, IL1β↓, IL6↓, TNF-α↓, iNOS↓, COX2↓, ROS↓, Bcl-2↓, PARP↓, P53↑, BAX↑, Casp3↑, TumCCA↑, Cyt‑c↑, MMP↓, eff↑,
1668- PBG,    Propolis: A Detailed Insight of Its Anticancer Molecular Mechanisms
- Review, Var, NA
antiOx↑, Inflam↓, AntiCan↑, TumCP↓, Apoptosis↑, eff↝, MMPs↓, TNF-α↓, iNOS↓, COX2↓, IL1β↑, *BioAv↓, BAX↑, Casp3↑, Cyt‑c↑, Bcl-2↓, eff↑, selectivity↑, P53↑, ROS↑, Casp↑, eff↑, ERK↓, Dose∅, TRAIL↑, NF-kB↑, ROS↑, Dose↑, MMP↓, DNAdam↑, TumAuto↑, LC3II↑, p62↓, EGF↓, Hif1a↓, VEGF↓, TLR4↓, GSK‐3β↓, NF-kB↓, Telomerase↓, ChemoSen↑, ChemoSideEff↓,
5187- PEITC,    Phenethyl Isothiocyanate Inhibits Migration and Invasion of Human Gastric Cancer AGS Cells through Suppressing MAPK and NF-κB Signal Pathways
- in-vitro, GC, AGS
TumMeta↓, ERK↓, MKK7↓, PKCδ↓, Rho↓, uPA↓, MMP2↓, MMP9↓, RAS↓, VEGF↓, FAK↓, iNOS↓, COX2↓, TumCP↓,
4220- PI,    Piperine ameliorated memory impairment and myelin damage in lysolecethin induced hippocampal demyelination
- in-vivo, AD, NA - in-vivo, MS, NA
*memory↑, *iNOS↓, *NRF2↑, *HO-1↑, *TAC↑, *TNF-α↓, *IL1β↓, *NF-kB↓, *IL10↑, *FOXP3↑, *BDNF↑, other↑,
2971- PL,    Piperlongumine attenuates IL-1β-induced inflammatory response in chondrocytes
- NA, OS, NA
*NO↓, *PGE2↓, *iNOS↓, *COX2↓, *MMP3↑, *MMP13↓, *Inflam↓,
5034- PTS,    Pterostilbene in Cancer Therapy
- Review, Var, NA
BioAv↓, Half-Life↓, iNOS↓, Apoptosis↑, STAT3↓, Akt↓, mTOR↓, NF-kB↓, NRF2↓, ChemoSen↑, BBB↑,
3929- PTS,    New Insights into Dietary Pterostilbene: Sources, Metabolism, and Health Promotion Effects
- Review, Var, NA - Review, Arthritis, NA
*NRF2↑, *BioAv↑, *ROS↓, *Inflam↓, *HO-1↑, *SOD↑, *Catalase↑, *GPx↑, *lipid-P↓, *hepatoP↑, *neuroP↑, *iNOS↓, *COX2↓, TumMeta↓, SOD2↓, ROS↑, TumCI↓, TumCG↓, HDAC1↓, PTEN↑, BP↓, *GutMicro↑,
3918- PTS,    Pterostilbene inhibits amyloid-β-induced neuroinflammation in a microglia cell line by inactivating the NLRP3/caspase-1 inflammasome pathway
- in-vitro, AD, BV2
*IL6↓, *IL1β↓, *TNF-α↓, *NLRP3↓, *Inflam↓, *NO↓, *iNOS↓,
3602- QC,    The flavonoid quercetin ameliorates Alzheimer's disease pathology and protects cognitive and emotional function in aged triple transgenic Alzheimer's disease model mice
- in-vivo, AD, NA
*BACE↓, *cognitive↑, *ROS↓, *lipid-P↓, *iNOS↓, *COX2↓, *BBB↑, *neuroP↑, *other↓, *memory↑,
3336- QC,    Neuroprotective Effects of Quercetin in Alzheimer’s Disease
- Review, AD, NA
*neuroP↑, *lipid-P↓, *antiOx↑, *Aβ↓, *Inflam↓, *BBB↝, *NF-kB↓, *iNOS↓, *memory↑, *cognitive↑, *AChE↓, *MMP↑, *ROS↓, *ATP↑, *AMPK↑, *NADPH↓, *p‑tau↓,
3338- QC,    Quercetin: Its Antioxidant Mechanism, Antibacterial Properties and Potential Application in Prevention and Control of Toxipathy
- Review, Var, NA - Review, Stroke, NA
*antiOx↑, *GSH↑, *ROS↓, *Dose↑, *NADPH↓, *AMP↓, *NF-kB↓, *p38↑, *MAPK↑, *SOD↑, *MDA↓, *iNOS↓, *Catalase↑, *PI3K↑, *Akt↑, *lipid-P↓, *memory↑, *radioP↑, *neuroP↑, *MDA↓,
3361- QC,    Quercetin ameliorates testosterone secretion disorder by inhibiting endoplasmic reticulum stress through the miR-1306-5p/HSD17B7 axis in diabetic rats
- in-vivo, Nor, NA - in-vitro, NA, NA
*BG↓, *ROS↓, *SOD↑, *MDA↓, *ER Stress↓, *iNOS↓, *CHOP↓, *GRP78/BiP↓, *antiOx↓, *Inflam↓, *JAK2↑, *STAT3?,
3368- QC,    The potential anti-cancer effects of quercetin on blood, prostate and lung cancers: An update
- Review, Var, NA
*Inflam↓, *antiOx↑, *AntiCan↑, Casp3↓, p‑Akt↓, p‑mTOR↓, p‑ERK↓, β-catenin/ZEB1↓, Hif1a↓, AntiAg↓, VEGFR2↓, EMT↓, EGFR↓, MMP2↓, MMP↓, TumMeta↓, MMPs↓, Akt↓, Snail↓, N-cadherin↓, Vim↓, E-cadherin↑, STAT3↓, TGF-β↓, ROS↓, P53↑, BAX↑, PKCδ↓, PI3K↓, COX2↓, cFLIP↓, cycD1/CCND1↓, cMyc↓, IL6↓, IL10↓, Cyt‑c↑, TumCCA↑, DNMTs↓, HDAC↓, ac‑H3↑, ac‑H4↑, Diablo↑, Casp3↑, Casp9↑, PARP1↑, eff↑, PTEN↑, VEGF↓, NO↓, iNOS↓, ChemoSen↑, eff↑, eff↑, eff↑, uPA↓, CXCR4↓, CXCL12↓, CLDN2↓, CDK6↓, MMP9↓, TSP-1↑, Ki-67↓, PCNA↓, ROS↑, ER Stress↑,
3372- QC,  FIS,  KaempF,    Anticancer Potential of Selected Flavonols: Fisetin, Kaempferol, and Quercetin on Head and Neck Cancers
- Review, HNSCC, NA
ROCK1↑, TumCCA↓, HSPs↓, RAS↓, ROS↑, Ca+2↑, MMP↓, Cyt‑c↑, Endon↑, MMP9↓, MMP2↓, MMP7↓, MMP-10↓, VEGF↓, NF-kB↓, p65↓, iNOS↓, COX2↓, uPA↓, PI3K↓, FAK↓, MEK↓, ERK↓, JNK↓, p38↓, cJun↓, FOXO3↑,
39- QC,    A Comprehensive Analysis and Anti-Cancer Activities of Quercetin in ROS-Mediated Cancer and Cancer Stem Cells
- Analysis, NA, NA
ROS↑, GSH↓, IL6↓, COX2↓, IL8↓, iNOS↓, TNF-α↓, MAPK↑, ERK↑, SOD↑, ATP↓, Casp↑, PI3K/Akt↓, mTOR↓, NOTCH1↓, Bcl-2↓, BAX↑, IFN-γ↓, TumCP↓, TumCCA↑, Akt↓, P70S6K↓, *Keap1↓, *GPx↑, *Catalase↑, *HO-1↑, *NRF2↑, NRF2↑, eff↑, HIF-1↓,
923- QC,    Quercetin as an innovative therapeutic tool for cancer chemoprevention: Molecular mechanisms and implications in human health
- Review, Var, NA
ROS↑, GSH↓, Ca+2↝, MMP↓, Casp3↑, Casp8↑, Casp9↑, other↓, *ROS↓, *NRF2↑, HO-1↑, TumCCA↑, Inflam↓, STAT3↓, DR5↑, P450↓, MMPs↓, IFN-γ↓, IL6↓, COX2↓, IL8↓, iNOS↓, TNF-α↓, cl‑PARP↑, Apoptosis↑, P53↑, Sp1/3/4↓, survivin↓, TRAILR↑, Casp10↑, DFF45↑, TNFR 1↑, Fas↑, NF-kB↓, IKKα↓, cycD1/CCND1↓, Bcl-2↓, BAX↑, PI3K↓, Akt↓, E-cadherin↓, Vim↓, β-catenin/ZEB1↓, cMyc↓, EMT↓, MMP2↓, NOTCH1↓, MMP7↓, angioG↓, TSP-1↑, CSCs↓, XIAP↓, Snail↓, Slug↓, LEF1↓, P-gp↓, EGFR↓, GSK‐3β↓, mTOR↓, RAGE↓, HSP27↓, VEGF↓, TGF-β↓, COL1↓, COL3A1↓,
2338- QC,    Quercetin: A Flavonoid with Potential for Treating Acute Lung Injury
- Review, Nor, NA
*SIRT1↑, *NLRP3↓, *Inflam↓, *TNF-α↓, *IL1β↓, *IL6↓, *PKM2↓, *HO-1↑, *ROS↓, *NO↓, *MDA↓, *antiOx↑, *COX2↓, *HMGB1↓, *iNOS↓, *NF-kB↓,
4286- RES,    Neuroprotective Properties of Resveratrol and Its Derivatives—Influence on Potential Mechanisms Leading to the Development of Alzheimer’s Disease
- Review, AD, NA
*neuroP↑, *Inflam↓, *antiOx↑, *GSH↑, *HO-1↑, *iNOS↓, *BDNF↑, *p‑CREB↑, *PKA↑, *Bcl-2↑, *BAX↓, *IL1β↓, *IL6↓, *MMP9↓, *memory↑, *AMPK↑, *PGC-1α↓, *NF-kB↓, *Aβ↓, *SIRT1↑, *p‑tau↓, *PP2A↑, *lipid-P↓, *NLRP3↓, *BACE↓,
882- RES,    Resveratrol: A Double-Edged Sword in Health Benefits
- Review, NA, NA
AntiTum↑, Casp3↑, Casp9↑, BAX↑, Bcl-2↓, Bcl-xL↓, P53↑, NAF1↓, NRF2↑, ROS↑, Apoptosis↑, HDAC↓, TumCCA↑, TumAuto↑, angioG↓, iNOS↓,
3057- RES,    The therapeutic effect of resveratrol: Focusing on the Nrf2 signaling pathway
- Review, Var, NA - Review, AD, NA - Review, Stroke, NA
*NRF2↑, *Keap1↓, *ROS↓, *Apoptosis↓, *Inflam↓, *antiOx↑, *hepatoP↑, *neuroP↑, *cardioP↑, *RenoP↑, *AntiCan↑, *memory↑, *SOD↑, *GPx↑, *Catalase↑, *MDA↓, *NRF2↑, *HO-1↑, *ROS↓, *Aβ↓, *iNOS↓, *COX2↓, *GSH↑, *HO-1⇅, *SIRT1↑,
2987- RES,    Resveratrol ameliorates myocardial damage by inducing vascular endothelial growth factor-angiogenesis and tyrosine kinase receptor Flk-1
- in-vivo, Nor, NA
*VEGF↑, *iNOS↑, *NF-kB↑, *Sp1/3/4↑, *cardioP↑,
3007- RosA,    Hepatoprotective effects of rosmarinic acid: Insight into its mechanisms of action
- Review, NA, NA
*ROS↓, *lipid-P↓, *Inflam↓, *neuroP↑, *angioG↓, *eff↑, *AST↓, *ALAT↓, *GSSG↓, *eNOS↓, *iNOS↓, *NO↓, *NF-kB↓, *MMP2↓, *MDA↓, *TNF-α↓, *GSH↑, *SOD↑, *IL6↓, *PGE2↓, *COX2↓, *mTOR↑,
3616- RosA,    Therapeutic effects of rosemary (Rosmarinus officinalis L.) and its active constituents on nervous system disorders
- Review, AD, NA
*Inflam↓, *memory↑, *toxicity↓, *ROS↓, *Catalase↑, *SOD↑, *NRF2↑, *Aβ↓, *AChE↓, *Ca+2↓, *NO↓, *IL2↓, *COX2↓, *PGE2↓, *MMPs↓, *TNF-α↓, *iNOS↓, *TLR4↓, *cognitive↑, *cortisol↓, *lipid-P↓,
3934- RT,    Rutin: A Potential Therapeutic Agent for Alzheimer Disease
- Review, AD, NA
*ROS↓, *Aβ↓, *neuroP↑, *memory↑, *GSH↑, *SOD↑, *lipid-P↓, *MDA↓, *IL1β↓, *IL6↓, *cognitive↑, *BBB↑, *MAPK↑, *IL8↓, *COX2↓, *NF-kB↓, *iNOS↓,
3933- RT,    The Pharmacological Potential of Rutin
- Review, AD, NA - Review, Stroke, NA - Review, Arthritis, NA
*antiOx↑, *neuroP↑, *cardioP↑, *Inflam↓, *TNF-α↓, *IL1β↓, *IL8↓, *COX2↓, *iNOS↓, *NF-kB↓, *cognitive↑, *Cartilage↑, *AntiAg↑, *ROS↓, *lipid-P↓, *hepatoP↑, *ALAT↓, *AST↓, *RenoP↑,
3663- SFN,    Efficacy of Sulforaphane in Neurodegenerative Diseases
- Review, AD, NA - Review, Park, NA
*antiOx↑, *Inflam↓, *Half-Life↝, *NRF2↑, *NQO1↑, *HO-1↑, *TrxR↑, *ROS↓, *TNF-α↓, *IL1β↓, *IL6↓, *iNOS↓, *COX2↓, *Aβ↓, *GSH↑, *cognitive↑, *BACE↓, *HSP70/HSPA5↑, *neuroP↑, *ROS↓, *BBB↑, *MMP9↓,
3659- SFN,    Epigenetic modification of Nrf2 by sulforaphane increases the antioxidative and anti-inflammatory capacity in a cellular model of Alzheimer's disease
- in-vitro, AD, NA
*NRF2↑, *ROS↓, *MDA↓, *SOD↑, *IL1β↓, *IL6↓, *NF-kB↓, *COX2↓, *iNOS↓, *Inflam↓,
3658- SFN,    Pre-Clinical Neuroprotective Evidences and Plausible Mechanisms of Sulforaphane in Alzheimer’s Disease
- Review, AD, NA
*NRF2↑, *antiOx↑, *neuroP↑, *Aβ↓, *BACE↓, *NQO1↑, *IL1β↓, *TNF-α↓, *IL6↓, *COX2↓, *iNOS↓, *NF-kB↓, *NLRP3↓, *Ca+2↓, *GSH↑, *MDA↓, *ROS↓, *SOD↑, *HO-1↑, *TrxR↑, *cognitive↑, *tau↓, *HSP70/HSPA5↑,
1478- SFN,  acet,    Anti-inflammatory and anti-oxidant effects of combination between sulforaphane and acetaminophen in LPS-stimulated RAW 264.7 macrophage cells
- in-vitro, Nor, NA
eff↑, NO↓, iNOS↓, COX2↓, IL1β↓, ROS↓,
3331- SIL,    The clinical anti-inflammatory effects and underlying mechanisms of silymarin
- Review, NA, NA
*Inflam↓, *NF-kB↓, *NLRP3↓, *COX2↓, *iNOS↓, *neuroP↑, *p‑ERK↓, *p38↓, *MAPK↓, *EGFR↓, *ROS↓, *lipid-P?, *5LO↓,
3330- SIL,    Mechanistic Insights into the Pharmacological Significance of Silymarin
- Review, Var, NA
*neuroP↑, *hepatoP↑, *cardioP↑, *antiOx↓, *NLRP3↓, *NAD↑, ROS↓, NLRP3↓, TumCMig↓, *COX2↓, *iNOS↓, *MPO↓, *AChE↓, *LDH↓, *Telomerase↓, *Fas↓,
3329- SIL,    iNOS_expression_in_the_brain_and_Gills_of_the_hypoxic-reoxygenated_rainbow_trout_Oncorhynchus_mykis">Silymarin regulates the HIF-1 and iNOS expression in the brain and Gills of the hypoxic-reoxygenated rainbow trout (Oncorhynchus mykis)
- in-vivo, Nor, NA
*NO↓, *MDA↓, *TAC↑, *Hif1a↓, *iNOS↓,
3328- SIL,    Modulatory effect of silymarin on inflammatory mediators in experimentally induced benign prostatic hyperplasia: emphasis on PTEN, HIF-1α, and NF-κB
- in-vivo, BPH, NA
*NF-kB↓, *Hif1a↓, *PTEN↑, *Weight↓, *NO↓, *IL6↓, *IL8↓, *COX2↓, *iNOS↓,
3325- SIL,    Modulatory effect of silymarin on pulmonary vascular dysfunction through HIF-1α-iNOS following rat lung ischemia-reperfusion injury
- in-vivo, Nor, NA
*Inflam↓, *ROS↓, *Casp3↑, *Casp9↑, *Hif1a↓, *iNOS↓, *SOD↑, *MDA↓,

Showing Research Papers: 51 to 100 of 123
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 123

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,   Catalase↑, 1,   CYP1A1↓, 1,   GSH↓, 2,   GSH↑, 1,   H2O2↓, 1,   HO-1↑, 1,   lipid-P↓, 1,   MPO↓, 1,   NAF1↓, 1,   NRF2↓, 1,   NRF2↑, 3,   ROS↓, 7,   ROS↑, 16,   SOD↑, 1,   SOD2↓, 1,  

Mitochondria & Bioenergetics ⓘ

ATP↓, 2,   EGF↓, 1,   MEK↓, 1,   MKK7↓, 1,   MMP↓, 7,   mtDam↑, 2,   OCR↓, 1,   XIAP↓, 1,  

Core Metabolism/Glycolysis ⓘ

cMyc↓, 2,   Glycolysis↓, 1,   HK2↓, 1,   LDH↓, 3,   i-LDH↓, 1,   PFK↓, 1,   PI3K/Akt↓, 1,   PKM2↓, 1,  

Cell Death ⓘ

Akt↓, 8,   p‑Akt↓, 3,   Apoptosis?, 1,   Apoptosis↑, 7,   BAX↓, 1,   BAX↑, 6,   Bax:Bcl2↑, 1,   Bcl-2↓, 6,   Bcl-xL↓, 1,   Casp↑, 2,   Casp10↑, 1,   Casp3↓, 2,   Casp3↑, 6,   Casp8↑, 1,   Casp9↑, 3,   cFLIP↓, 1,   Cyt‑c↑, 4,   Diablo↑, 1,   DR5↑, 2,   Endon↑, 1,   Fas↑, 1,   hTERT/TERT↓, 1,   iNOS↓, 13,   iNOS↑, 1,   JNK↓, 2,   p‑JNK↓, 1,   MAPK↓, 1,   MAPK↑, 1,   necrosis↑, 1,   p27↓, 1,   p38↓, 1,   survivin↓, 2,   Telomerase↓, 1,   TNFR 1↑, 1,   TRAIL↑, 1,   TRAILR↑, 1,  

Kinase & Signal Transduction ⓘ

Sp1/3/4↓, 1,  

Transcription & Epigenetics ⓘ

cJun↓, 1,   ac‑H3↑, 1,   ac‑H4↑, 1,   other↓, 1,   other↑, 1,   tumCV↓, 1,  

Protein Folding & ER Stress ⓘ

ER Stress↑, 2,   HSP27↓, 1,   HSP70/HSPA5↑, 1,   HSP90↓, 1,   HSPs↓, 1,  

Autophagy & Lysosomes ⓘ

LC3II↑, 2,   p62↓, 2,   TumAuto↑, 3,  

DNA Damage & Repair ⓘ

DFF45↑, 1,   DNAdam↑, 3,   DNMTs↓, 1,   P53↑, 6,   PARP↓, 1,   cl‑PARP↑, 1,   PARP1↑, 1,   PCNA↓, 2,   TP53↓, 1,  

Cell Cycle & Senescence ⓘ

CDK2↓, 2,   CDK4↓, 1,   cycA1/CCNA1↓, 1,   cycD1/CCND1↓, 5,   cycE/CCNE↓, 1,   P21↓, 1,   P21↑, 3,   TumCCA↓, 1,   TumCCA↑, 8,  

Proliferation, Differentiation & Cell State ⓘ

CSCs↓, 1,   EMT↓, 2,   ERK↓, 4,   ERK↑, 1,   p‑ERK↓, 2,   FOXO3↑, 1,   GSK‐3β↓, 3,   HDAC↓, 2,   HDAC1↓, 1,   HDAC8↓, 1,   IGF-1?, 1,   mTOR↓, 5,   p‑mTOR↓, 1,   NOTCH1↓, 2,   P70S6K↓, 1,   PI3K↓, 4,   p‑PI3K↓, 1,   PTEN↑, 2,   RAS↓, 2,   STAT3↓, 5,   TumCG↓, 2,  

Migration ⓘ

AntiAg↓, 1,   Ca+2↑, 1,   Ca+2↝, 1,   CLDN2↓, 1,   COL1↓, 1,   COL3A1↓, 1,   CXCL12↓, 1,   E-cadherin↓, 1,   E-cadherin↑, 2,   FAK↓, 2,   Ki-67↓, 2,   LEF1↓, 1,   MMP-10↓, 1,   MMP2↓, 6,   MMP7↓, 4,   MMP9↓, 5,   MMPs↓, 4,   N-cadherin↓, 1,   PKCδ↓, 2,   RAGE↓, 1,   Rho↓, 1,   ROCK1↑, 1,   Slug↓, 1,   Snail↓, 2,   TGF-β↓, 2,   TIMP1↓, 1,   TIMP1↑, 1,   TIMP2↑, 1,   TSP-1↑, 2,   TumCA↓, 1,   TumCI↓, 4,   TumCMig↓, 4,   TumCP↓, 7,   TumMeta↓, 3,   uPA↓, 3,   Vim↓, 2,   β-catenin/ZEB1↓, 2,  

Angiogenesis & Vasculature ⓘ

angioG↓, 2,   EGFR↓, 2,   eNOS↑, 1,   HIF-1↓, 1,   Hif1a↓, 3,   NO↓, 3,   VEGF↓, 7,   VEGFR2↓, 1,  

Barriers & Transport ⓘ

BBB↑, 1,   P-gp↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 11,   CXCR4↓, 1,   IFN-γ↓, 2,   IKKα↓, 1,   IL10↓, 3,   IL1β↓, 3,   IL1β↑, 1,   IL4↓, 1,   IL6↓, 5,   IL8↓, 2,   Inflam↓, 4,   p‑IκB↓, 1,   NF-kB↓, 10,   NF-kB↑, 1,   p65↓, 2,   PGE2↓, 1,   PSA↓, 1,   TLR4↓, 2,   TNF-α↓, 5,  

Protein Aggregation ⓘ

NLRP3↓, 1,  

Hormonal & Nuclear Receptors ⓘ

CDK6↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 2,   BioAv↝, 1,   ChemoSen↓, 1,   ChemoSen↑, 4,   Dose↑, 1,   Dose∅, 3,   eff↑, 19,   eff⇅, 1,   eff↝, 1,   Half-Life↓, 1,   P450↓, 1,   RadioS↑, 1,   selectivity↑, 3,  

Clinical Biomarkers ⓘ

BP↓, 1,   EGFR↓, 2,   hTERT/TERT↓, 1,   IL6↓, 5,   Ki-67↓, 2,   LDH↓, 3,   i-LDH↓, 1,   PSA↓, 1,   RAGE↓, 1,   TP53↓, 1,  

Functional Outcomes ⓘ

AntiCan↑, 4,   AntiTum↑, 1,   chemoP↑, 1,   ChemoSideEff↓, 1,   cognitive↑, 1,   OS↑, 1,  
Total Targets: 219

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↓, 2,   antiOx↑, 14,   Catalase↑, 6,   Copper↓, 1,   Fenton↓, 1,   GPx↑, 5,   GSH↑, 11,   GSR↓, 1,   GSR↑, 1,   GSSG↓, 1,   HO-1↑, 10,   HO-1⇅, 1,   Iron↓, 1,   Keap1↓, 2,   lipid-P?, 1,   lipid-P↓, 9,   MDA↓, 12,   MPO↓, 1,   NQO1↑, 2,   NRF2↑, 13,   ROS↓, 30,   SOD↑, 13,   TAC↑, 2,   TrxR↑, 2,   uricA↓, 1,  

Mitochondria & Bioenergetics ⓘ

ATP↑, 1,   MMP↑, 1,   PGC-1α↓, 1,  

Core Metabolism/Glycolysis ⓘ

ALAT↓, 2,   AMP↓, 1,   AMPK↑, 2,   p‑CREB↑, 1,   LDH↓, 1,   LDL↓, 1,   NAD↑, 1,   NADPH↓, 2,   PKM2↓, 1,   PPARγ↑, 1,   SIRT1↑, 3,  

Cell Death ⓘ

Akt↑, 1,   Apoptosis↓, 1,   BAX↓, 2,   Bcl-2↑, 1,   Casp3↓, 2,   Casp3↑, 1,   Casp9↑, 1,   Fas↓, 1,   iNOS↓, 34,   iNOS↑, 2,   JNK↓, 1,   p‑JNK↓, 1,   MAPK↓, 3,   MAPK↑, 2,   necrosis↓, 1,   p38↓, 1,   p38↑, 1,   p‑p38↓, 1,   Telomerase↓, 1,  

Kinase & Signal Transduction ⓘ

Sp1/3/4↑, 1,  

Transcription & Epigenetics ⓘ

cJun↓, 1,   p‑cJun↓, 1,   other↓, 1,   other↑, 1,  

Protein Folding & ER Stress ⓘ

CHOP↓, 1,   ER Stress↓, 1,   GRP78/BiP↓, 1,   HSP70/HSPA5↑, 4,  

DNA Damage & Repair ⓘ

DNAdam↓, 1,  

Cell Cycle & Senescence ⓘ

P21↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

cFos↓, 1,   ERK↓, 1,   p‑ERK↓, 1,   FGF↑, 1,   HDAC↓, 1,   mTOR↑, 1,   PI3K↑, 1,   PTEN↑, 1,   STAT↓, 1,   STAT3?, 1,  

Migration ⓘ

5LO↓, 1,   AntiAg↑, 2,   ARG↑, 1,   Ca+2↓, 2,   Ca+2↝, 1,   Cartilage↑, 2,   MMP1↓, 1,   MMP13↓, 1,   MMP2↓, 3,   MMP2↑, 1,   MMP3↑, 1,   MMP9↓, 3,   MMPs↓, 1,   PKA↑, 1,   PKCδ?, 1,   TGF-β↑, 1,   TGF-β1↑, 1,   VCAM-1↓, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 1,   EGFR↓, 1,   eNOS↓, 1,   Hif1a↓, 3,   NO↓, 11,   VEGF↑, 1,  

Barriers & Transport ⓘ

BBB↑, 4,   BBB↝, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 20,   FOXP3↑, 1,   HMGB1↓, 1,   p‑IKKα↓, 1,   IL1↓, 3,   IL10↑, 2,   IL12↓, 1,   IL1β↓, 17,   IL2↓, 1,   IL4↑, 1,   IL6↓, 15,   IL6↑, 1,   IL8↓, 3,   Inflam↓, 23,   Inflam↑, 1,   p‑IκB↓, 1,   JAK2↑, 1,   MCP1↓, 1,   MCP1↑, 1,   MyD88↓, 1,   NF-kB↓, 18,   NF-kB↑, 1,   p‑p65↓, 1,   PGE2↓, 4,   TLR4↓, 2,   TNF-α↓, 17,  

Synaptic & Neurotransmission ⓘ

AChE↓, 4,   AChE↑, 1,   BDNF↑, 3,   tau↓, 1,   p‑tau↓, 2,  

Protein Aggregation ⓘ

Aβ↓, 8,   BACE↓, 4,   NLRP3↓, 7,   PP2A↑, 1,  

Hormonal & Nuclear Receptors ⓘ

cortisol↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 1,   BioAv↑, 2,   Dose↑, 1,   Dose↝, 1,   eff↑, 3,   Half-Life↝, 2,  

Clinical Biomarkers ⓘ

ALAT↓, 2,   AST↓, 2,   BG↓, 1,   EGFR↓, 1,   GutMicro↑, 1,   IL6↓, 15,   IL6↑, 1,   LDH↓, 1,  

Functional Outcomes ⓘ

AntiCan↑, 2,   cardioP↑, 5,   cognitive↑, 8,   hepatoP↑, 4,   memory↑, 9,   motorD↑, 2,   neuroP↑, 18,   Pain↓, 2,   radioP↑, 2,   RenoP↑, 3,   toxicity↓, 1,   toxicity∅, 2,   Weight↓, 1,  

Infection & Microbiome ⓘ

Bacteria↓, 1,  
Total Targets: 169

Scientific Paper Hit Count for: iNOS, Inducible nitric oxide synthase
11 Silymarin (Milk Thistle) silibinin
9 Quercetin
7 Thymoquinone
6 Magnetic Fields
5 Baicalein
5 Curcumin
5 Propolis -bee glue
4 Alpha-Lipoic-Acid
4 Lycopene
4 Resveratrol
4 Sulforaphane (mainly Broccoli)
3 Ferulic acid
3 Pterostilbene
2 Silver-NanoParticles
2 Allicin (mainly Garlic)
2 Artemisinin
2 Boron
2 Caffeic acid
2 Chrysin
2 Fisetin
2 Luteolin
2 Magnolol
2 Rosmarinic acid
2 Rutin
2 Shikonin
2 Aflavin-3,3′-digallate
2 Vitamin K2
1 Anthocyanins
1 alpha Linolenic acid
1 Andrographis
1 Apigenin (mainly Parsley)
1 Ashwagandha(Withaferin A)
1 Astaxanthin
1 Cisplatin
1 Biochanin A
1 Bromelain
1 Boswellia (frankincense)
1 Bruteridin(bergamot juice)
1 Carnosic acid
1 Capsaicin
1 Celastrol
1 Lecithin
1 Dichloroacetate
1 Ellagic acid
1 EGCG (Epigallocatechin Gallate)
1 Ginkgo biloba
1 Melatonin
1 Magnetic Field Rotating
1 Methylsulfonylmethane
1 Oleocanthal
1 Phenylbutyrate
1 Phenethyl isothiocyanate
1 Piperine
1 Piperlongumine
1 Kaempferol
1 acetaminophen
1 Taurine
1 Ursolic acid
1 Vitamin C (Ascorbic Acid)
1 Zerumbone
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:159  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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