Iron Cancer Research Results

Iron, Iron: Click to Expand ⟱
Source:
Type:
Iron is an essential nutrient that is crucial for various cellular processes, including DNA synthesis, cell proliferation, and oxygen transport.
Cancer cells often have increased iron requirements due to their rapid growth and proliferation. Some tumors can acquire iron through various mechanisms, including upregulating iron transport proteins. This can support their growth and survival.
Excess iron can lead to the production of reactive oxygen species (ROS) through Fenton reactions, which can cause oxidative damage to DNA, proteins, and lipids. This oxidative stress can contribute to cancer development and progression.
Scientific Papers found: Click to Expand⟱
8078- KAE,    Kaempferol induces mitophagy and disrupts iron metabolism via SFXN2 leading to apoptosis in multiple myeloma cells
- in-vitro, Mye, NA
TumCP↓, Apoptosis↑, mtDam↑, mt-TumAuto↑, i-Iron↑, SFXN2↓,
8055- KAE,    Molecular Mechanisms of the Anticancer Activity of the Flavonoid Kaempferol: A Comprehensive Review
- Review, Var, NA
antiNeop↑, *toxicity↓, TumCCA↑, ROS↑, ER Stress↑, TumAuto↑, Pyro↑, Ferroptosis↑, angioG↓, Imm↝, Synergy↑, ChemoSen↑, MPT↑, MMP↓, mtDam↑, Cyt‑c↑, Bax:Bcl2↑, Fas↑, DR4↑, DR5↑, JNK↑, ERK↑, CHOP/DDIT3↑, ER Stress↑, UPR↑, Ca+2↑, PI3K↓, Akt↓, mTOR↓, AMPK↑, *Ferroptosis↓, *antiOx↑, *NRF2↑, *GPx4↑, *ROS↓, *MDA↓, *i-Iron↓, *xCT/SLC7A11↑, VEGF↓, Wnt↓, β-catenin/ZEB1↓, EMT↓, STAT3↓, M2 MC↓, MCP1/CCL2↓, MMP9↓, MMP2↓, TIMP2↓, ChemoSen↑, PKM2↑, Glycolysis↓, CSCs↓, SOX4↓, OCT4↓, CD44↓, Nanog↓, MDR1↓, *GutMicro↑,
8260- LCA,    Licochalcone A Induces Ferroptosis in Hepatocellular Carcinoma via Reactive Oxygen Species Activated by the SLC7A11/GPX4 Pathway
- vitro+vivo, Liver, HepG2 - in-vitro, Liver, HUH7
tumCV↑, xCT/SLC7A11↓, Ferroptosis↑, GPx4↑, ROS↑, TumCP↓, TumCD↑, Iron↑,
8225- LCA,  Cisplatin,    Licochalcone A protects against cisplatin-induced acute kidney injury via the modulation of Nrf2/Keap1-mediated ferroptosis and apoptosis
- in-vivo, Nor, NA
*RenoP↑, *Urea↓, *BUN↓, *creat↓, *Apoptosis↓, *Ferroptosis↓, *Iron↓, *ROS↓, *lipid-P↓, *mtDam↓, *NRF2↑,
8130- LF,    Lactoferrin targeting INTL1 receptor inhibits hepatocellular carcinoma progression via apoptosis and cell cycle signaling pathways
- in-vitro, HCC, HepG2 - in-vitro, HCC, HepG3 - in-vitro, HCC, SK-HEP-1
Iron↓, TumCP↓, selectivity↑, TumCCA↑, p‑MAPK↑, JNK↑, Apoptosis↑,
8131- LF,    Molecular mechanism of inhibitory effects of bovine lactoferrin on the growth of oral squamous cell carcinoma
- in-vitro, OS, HSC2 - in-vitro, OS, HSC3 - in-vitro, OS, HSC4 - in-vitro, Nor, RT7
P53↑, Akt↓, SOCS-3↑, mTOR↓, JAK↓, STAT3↓, selectivity↑, TumCP↓, Iron↓, TumCCA↑,
8132- LF,    Lactoferrin selectively triggers apoptosis in highly metastatic breast cancer cells through inhibition of plasmalemmal V-H+-ATPase
- in-vitro, BC, HS587T - in-vitro, BC, MDA-MB-231 - in-vitro, BC, T47D - in-vitro, BC, MCF10
Iron↓, AntiCan↑, Apoptosis↑, selectivity↑, ECAR↓, i-pH↑, ATPase↓,
8134- LF,    Bovine lactoferrin and lactoferricin exert antitumor activities on human colorectal cancer cells (HT-29) by activating various signaling pathways
- in-vitro, CRC, HT-29
Iron↓, Apoptosis↑, selectivity↑, Casp8↑, P53↑, P21↑,
8135- LF,    Lactoferrin-A Regulator of Iron Homeostasis and Its Implications in Cancer
- Review, Var, NA - Review, AD, NA
IronCh↑, ROS↓, Imm↑, Inflam↓, *BBB↑, Iron↝, *Fenton↓, *ROS↓, *TAC↑, *SOD↑, *GPx↑, *GSH↑, *TBARS↓, *PTEN↓, *tau↓, *MAPK↓, *Aβ42↓, *Apoptosis↓, *Casp3↓, *Akt↑, *GutMicro↑, *Sepsis↓, *anemia↓, *IL6↓, *FPN↑, *TfR1/CD71↑, *Ferritin↓, *HemoG↑, *RBC↑, *eff↑, *BioAv↓, *BioAv↑, *BioAv↝, *ChemoSen↑, *BioAv↑, Ferroptosis↑,
8139- LF,    Androgen Receptor‐Induced Lactoferrin Accelerates Prostate Tumorigenesis Through Modulating Ferroptosis
- vitro+vivo, Pca, NA
Ferroptosis↓, AR↝, Iron↝, Ferritin↑, P53↓, eff↝, other↝, AntiTum↓,
7825- LT,  MBS,    Neuroprotective Potential of Mung Bean (Vigna radiata L.) Polyphenols in Alzheimer's Disease: A Review
- Review, AD, NA
*neuroP↑, *OS↑, *antiOx↑, *Aβ42↓, *AChE↓, *Aβ↓, *IRes↓, *p‑tau↓, *ROS↓, *Apoptosis↓, *Inflam↓, *Iron↝,
8379- LT,    Luteolin and neuroinflammation: a multi-target therapeutic strategy for central nervous system disorders
- Review, Var, NA - Review, AD, NA - Review, Stroke, NA
*neuroP↑, *Inflam↓, *ROS↓, *Apoptosis↓, *BioAv↓, *BBB∅, Ferroptosis↑, ROS↑, Iron↑, lipid-P↑, MDA↑, GSH↓, GPx4↓, *Aβ↓, *memory↑, *neuroG↑, *NRF2↑, *NLRP3↓, *ROS↓, JAK2↓, STAT3↓, PD-L1↓, Perforin↝, GranB/GZMB↝, hepatoP↑, *Learn↑, *TNF-α↓, *IL1β↓, *IL6↓, *NO↓, *COX2/PTGS2↓, *iNOS↓, *ER Stress↓, *GRP78/BiP↓, *IRE1↓, *cognitive↑, *BAX↓, *Bcl-2↓, *Casp3↓, *PSD95↑, *SNAP25↑, *JNK↓, *eff↑, *mtDam↓, *MMP↑, *Stroke↓, *TJ↑, *MMP9↓, *BBB∅, *NeuroI↓,
8370- LT,    Luteolin Induces GPX4-dependent Ferroptosis and Enhances Immune Activation in Colon Cancer
- vitro+vivo, Colon, NA
TumCP↓, ROS↑, Iron↑, lipid-P↑, MDA↑, GSH↓, GPx4↓, Ferroptosis↑, pol-M1↑, CD8+↑, Imm↑,
1275- LT,    Mechanism of luteolin induces ferroptosis in nasopharyngeal carcinoma cells
- in-vitro, Laryn, NA
Ferroptosis↑, MDA↑, Iron↑, SOD↓, GSH↓, GPx4↓, SOX4↓, GDF15↓,
8535- Matr,    Matrine induces ferroptosis in cervical cancer through activation of piezo1 channel
- in-vitro, Cerv, NA
TumCG↓, *toxicity↓, Ferroptosis↑, GPx4↓, lipid-P↑, Iron↓, ROS↑, Piezo1↑,
8549- Matr,    Matrine disrupts Nrf2/GPX4 antioxidant system and promotes hepatocyte ferroptosis
- in-vitro, Var, NA
toxicity↑, *hepatoP↓, *SOD↓, *GSH↓, *MDA↑, *ROS↑, *lipid-P↑, *Iron↝, *Ferroptosis↑, *FTH1↓, *NRF2↓, *xCT/SLC7A11↓, *GPx4↓, *HO-1↓, *toxicity↝,
8547- Matr,    Matrine in cancer therapy: antitumor mechanisms and nano-delivery strategies
- Review, Var, NA
*Ingr↝, *AntiTum↑, Apoptosis↑, TumAuto↑, Ferroptosis↑, TumCP↓, TumCMig↓, TumCI↓, JPT1/HN1↓, Erlin1↑, LINC01116↓, miR-592↑, ERK↓, JAK↓, STAT3↓, miR-182-5p↓, PI3K↓, Akt↓, Wnt↓, β-catenin/ZEB1↓, Sharpin↓, ROS↓, AMPK↑, mTOR↓, Snail↓, Vim↓, N-cadherin↓, MMP2↓, MMP9↓, E-cadherin↑, PTEN↑, miR-10b-5p↓, GPx4↓, lipid-P↑, Iron↑, Piezo1↑,
8546- Matr,    Matrine Attenuates Neurological Deficits and Neuroinflammation by Inhibiting the HMGB1/RAGE Axis and Ferroptosis in Intracerebral Hemorrhage Mice
- in-vivo, Stroke, NA
*Dose?, *Stroke↓, *BBB↝, *TJ↑, *ZO-1↑, *OCLN↑, *CLDN4↑, *HMGB1↓, *RAGE↓, *JNK↓, *p38↓, *ERK↓, *NF-kB↓, *IL1β↓, *IL6↓, *TNF-α↓, *BAX↓, *Bcl-2↑, *Apoptosis↓, *Iron↓, *ACSL4↓, *GPx4↑, *Ferroptosis↓, *neuroP↑, *Inflam↓, *antiOx↑,
8545- Matr,    Matrine enhances RLS3-induced ferroptosis at non-toxic doses in acute myeloid leukemia cells with MLL rearrangement
- in-vitro, AML, MV411 - in-vitro, ALL, MOLM-13
Ferroptosis↑, Synergy↑, i-Iron↑, ROS↑, MMP↓, GSH↓, xCT/SLC7A11↓, GPx4↓, P53↑,
1204- MET,    Metformin induces ferroptosis through the Nrf2/HO-1 signaling in lung cancer
- in-vitro, Lung, A549 - in-vitro, Lung, H1299
MDA↑, ROS↑, Iron↑, GSH↓, T-SOD↓, Catalase↓, GPx4↓, xCT/SLC7A11↓, NRF2↓, HO-1↓,
8489- MF,    Pulsed electromagnetic fields induce ferroptosis in osteosarcoma cells and promote osteogenic differentiation
- in-vitro, OS, U2OS - in-vitro, OS, MG63
TumCP↓, TumCMig↓, Ferroptosis↑, GPx4↓, xCT/SLC7A11↓, BMD↑, selectivity↑, Dose↝, TumCG↓, Dose↝, OS↑, ROS↑, MDA↑, Iron↑, ChemoSen↑, TOP2↑, radioP↑,
8486- MF,    Silent forces, hidden currents: the influence of static magnetic field stimulation on tumor biophysics
- Review, Var, NA
Ca+2↑, TumCG↓, MMP↓, CellMemb↑, SOX2↓, Nanog↓, cMyc↓, CD44↓, CD133↓, P53↑, ROS↑, DNAdam↑, CDK1↓, CycB/CCNB1↓, TumCCA↑, TumCP↓, pH↓, TumCP↓, Telomerase↓, ChemoSen↑, TRPV1↝, Bax:Bcl2↑, Casp3↑, Akt↓, mTOR↓, mitA↑, ROS↓, P-gp/ABCB1↓, MDR1↓, RadioS↑, Apoptosis↑, GSH↓, lipid-P↑, Iron↑, Iron↓, Fenton↑,
8485- MF,  doxoR,    Static magnetic field promotes the doxorubicin toxicity effects on osteosarcoma cells
- in-vitro, OS, G292
tumCV↓, Dose↝, Apoptosis↑, ROS↑, i-Iron↓, *Ca+2↓, *Iron↑, *chemoP↑, ROS↓, ChemoSen↑, selectivity↑,
8479- MFrot,  doxoR,    Dual-targeting by rotating magnetic field-driven superparamagnetic bionic nanorobots for enhanced triple-negative breast cancer therapy
- vitro+vivo, BC, 4T1
Dose?, EPR↑, BioEnh↑, GSH↓, GPx4↓, Iron↑, ROS↑, lipid-P↑, Ferroptosis↑, TumVol↓, Fenton↑,
1777- MLT,    Melatonin as an antioxidant: under promises but over delivers
- Review, Var, NA
*ROS↓, *Fenton↓, *antiOx↑, *toxicity∅, *GPx↑, *GSR↑, *GSH↑, *NO↓, *Iron↓, *Copper↓, *IL1β↓, *iNOS↓, *Casp3↓, *BBB↑, *RenoP↑, chemoP↑, *Ca+2↝, eff↑, *PKCδ?, ChemoSen↑, eff↑, Akt↓, DR5↑, selectivity↑, ROS↑, Synergy↑,
582- MNPs,  immuno,  VitC,    Magnetic field boosted ferroptosis-like cell death and responsive MRI using hybrid vesicles for cancer immunotherapy
- in-vitro, Pca, TRAMP-C1 - in-vivo, NA, NA
Fenton↑, Ferroptosis↑, ROS↑, TumCG↓, Iron↑, GPx4↓,
8882- MOR,  Cisplatin,    Morin hydrate protects against cisplatin-induced testicular toxicity by modulating ferroptosis and steroidogenesis genes' expression and upregulating Nrf2/Heme oxygenase-1
- in-vivo, Nor, NA
*antiOx↑, *Inflam↓, *Apoptosis↓, *Dose?, *SOD↑, *GPx↑, *NRF2↑, *HO-1↑, *MDA↓, *other↑, *Ferroptosis↓, *Iron↓, *ROS↓, *other↓, ChemoSen↑, *chemoP↑, *selectivity↑,
7828- Myr,  MBS,    Neuroprotective Potential of Mung Bean (Vigna radiata L.) Polyphenols in Alzheimer's Disease: A Review
- Review, AD, NA
*BBB↑, *neuroP↑, *cognitive↑, *Aβ↓, *ADAM10↑, *BACE/β-secretase↝, *IronCh↑, *Iron↓, *AChE↓, *ROS↓,
1273- Myr,    Myricetin Induces Ferroptosis and Inhibits Gastric Cancer Progression by Targeting NOX4
- vitro+vivo, GC, NA
Ferroptosis↑, MDA↑, Iron↑, GSH↓, NOX4↑, NRF2↓, GPx4↓,
4927- PEITC,    Targeting ferroptosis in osteosarcoma
- Review, OS, NA
AntiCan↑, BioAv↑, Ferroptosis↑, TfR1/CD71↑, Iron↑, ROS↑, MDA↑, lipid-P↑, GPx4↓,
2343- QC,    Pharmacological Activity of Quercetin: An Updated Review
- Review, Nor, NA
*ROS↓, *GSH↑, *Catalase↑, *SOD↑, *MDA↓, *GPx↑, *Copper↓, *Iron↓, Apoptosis↓, TumCCA↑, MMP2↓, MMP9↓, GlucoseCon↓, lactateProd↓, PKM2↓, GLUT1↓, LDHA↓, ROS↑,
5026- QC,    Quercetin induces ferroptosis in gastric cancer cells by targeting SLC1A5 and regulating the p-Camk2/p-DRP1 and NRF2/GPX4 Axes
- in-vitro, GC, NA
SLC1A5↓, ROS↑, Iron↓, NRF2↓, GPx4↓, Ferroptosis↑,
1748- RosA,    The Role of Rosmarinic Acid in Cancer Prevention and Therapy: Mechanisms of Antioxidant and Anticancer Activity
- Review, Var, NA
AntiCan↑, *BioAv↝, *CardioT↓, *Iron↓, *ROS↓, *SOD↑, *Catalase↑, *GPx↑, *NRF2↑, MARK4↓, MMP9↓, TumCCA↑, Bcl-2↓, BAX↑, Apoptosis↑, E-cadherin↑, N-cadherin↓, Vim↓, Gli1↓, HDAC2↓, Warburg↓, Hif1a↓, miR-155↓, p‑PI3K↑, ROS↑, *IronCh↑,
1743- RosA,    New insights into the competition between antioxidant activities and pro-oxidant risks of rosmarinic acid
- Analysis, Var, NA
ROS↑, Fenton↑, eff↑, antiOx↑, Iron↓, ROS↑,
4911- Sal,    MUC1-C is a target of salinomycin in inducing ferroptosis of cancer stem cells
- in-vitro, Var, DU145
MUC1-C↓, Ferroptosis↑, CSCs↓, NF-kB↓, GSR↓, GSH↑, Iron↑,
4898- Sal,    Salinomycin as a potent anticancer stem cell agent: State of the art and future directions
- Review, Var, NA
CSCs↓, AntiCan↑, ChemoSen↑, RadioS↑, Wnt↓, MAPK↓, TumAuto↑, ATP↓, ROS↑, DNAdam↑, ER Stress↑, CSCsMark↓, Iron↑, *toxicity↝,
4904- Sal,  CUR,    Co-delivery of Salinomycin and Curcumin for Cancer Stem Cell Treatment by Inhibition of Cell Proliferation, Cell Cycle Arrest, and Epithelial–Mesenchymal Transition
- in-vitro, Var, NA
CSCs↓, TumCCA↑, EMT↓, other↝, TumAuto↑, Iron↑, Ferroptosis↑, BioAv↓, ROS↑, lipid-P↑, GPx4↓, Synergy↑,
4906- Sal,    A Concise Review of Prodigious Salinomycin and Its Derivatives Effective in Treatment of Breast Cancer: (2012–2022)
- Review, BC, NA
CSCs↓, Casp3↑, cl‑PARP↝, Apoptosis↑, ROS↑, ABC↓, OXPHOS↓, Glycolysis↓, Synergy↑, TumAuto↑, DNAdam↑, Wnt↓, Ferritin↓, Iron↑,
5139- SAS,    Sulfasalazine induces ferroptosis in osteosarcomas by regulating Nrf2/SLC7A11/GPX4 signaling axis
- in-vitro, OS, MG63 - in-vitro, OS, U2OS
*Inflam↓, TumCP↓, TumCMig↓, Apoptosis↑, Ferroptosis↑, Iron↑, MDA↑, ROS↑, GSH↓, SOD↓, MMP↓, NRF2↓, xCT/SLC7A11↓, GPx4↓, FTH1↓,
1483- SFN,    Targeting p62 by sulforaphane promotes autolysosomal degradation of SLC7A11, inducing ferroptosis for osteosarcoma treatment
- in-vitro, OS, 143B - in-vitro, Nor, HEK293 - in-vivo, OS, NA
AntiCan↑, *toxicity∅, Ferroptosis↑, ROS↑, lipid-P↑, GSH↓, p62↑, SLC12A5↓, eff↓, GPx4↓, i-Iron↑, eff↓, MDA↑, TumVol↓, TumW↓, Ki-67↓, LC3B↑, *Weight∅,
1479- SFN,    Sulforaphane triggers Sirtuin 3-mediated ferroptosis in colorectal cancer cells via activating the adenosine 5'-monophosphate (AMP)-activated protein kinase/ mechanistic target of rapamycin signaling pathway
- in-vitro, CRC, HCT116
Ferroptosis↑, SIRT3↑, AMPK↑, mTOR↑, tumCV↓, ROS↑, MDA↑, Iron↑,
1284- SK,    Shikonin induces ferroptosis in multiple myeloma via GOT1-mediated ferritinophagy
- in-vitro, Melanoma, RPMI-8226 - in-vitro, Melanoma, U266
Ferroptosis↑, LDH↓, ROS↑, Iron↑, lipid-P↑, ATP↓, HMGB1↓, GPx4↓, MDA↑, SOD↓, GSH↓,
2201- SK,    Shikonin promotes ferroptosis in HaCaT cells through Nrf2 and alleviates imiquimod-induced psoriasis in mice
- in-vitro, PSA, HaCaT - in-vivo, NA, NA
*eff↑, *IL6↓, *IL17↓, *TNF-α↓, *lipid-P↑, *NRF2↓, *HO-1↝, *NCOA4↝, *GPx4↓, *Ferroptosis↓, *Inflam↓, *ROS↓, *Iron↓,
2199- SK,    Induction of Ferroptosis by Shikonin in Gastric Cancer via the DLEU1/mTOR/GPX4 Axis
- in-vitro, GC, NA
ROS↑, lipid-P↑, Iron↑, MDA↑, GPx4↓, Ferritin↓, DLEU1↓, mTOR↓, Ferroptosis↑,
2198- SK,    Shikonin suppresses proliferation of osteosarcoma cells by inducing ferroptosis through promoting Nrf2 ubiquitination and inhibiting the xCT/GPX4 regulatory axis
- in-vitro, OS, MG63 - in-vitro, OS, 143B
TumCP↓, TumCCA↑, Ferroptosis↑, Iron↑, ROS↑, lipid-P↑, MDA↑, mtDam↑, NRF2↓, xCT/SLC7A11↓, GPx4↓, GSH/GSSG↓, Keap1↑,
2195- SK,    Shikonin induces ferroptosis in osteosarcomas through the mitochondrial ROS-regulated HIF-1α/HO-1 axis
- in-vitro, OS, NA
TumCP↓, Ferroptosis↓, Hif1a↑, HO-1↑, Iron↑, ROS↑, GSH/GSSG↓, GPx4↓,
2202- SK,    Enhancing Tumor Therapy of Fe(III)-Shikonin Supramolecular Nanomedicine via Triple Ferroptosis Amplification
- in-vitro, Var, NA
Iron↑, Ferroptosis↑, pH↝, H2O2↑, ROS↑, Fenton↑, GSH↓, GPx4↓, lipid-P↑,
4892- Sper,  erastin,    Spermidine inactivates proteasome activity and enhances ferroptosis in prostate cancer
- in-vitro, Pca, PC3 - in-vivo, Pca, NA
Ferroptosis↑, lipid-P↑, Iron↑, Synergy↑, HO-1↑, NRF2↑, ROS↑, AntiTum↑, eff↓,
5091- SSE,    Superoxide-mediated ferroptosis in human cancer cells induced by sodium selenite
- in-vitro, GBM, U87MG - in-vitro, Cerv, HeLa - in-vitro, BC, MCF7 - in-vitro, Pca, PC3 - in-vitro, CRC, HT-29 - in-vitro, Nor, SVGp12
Ferroptosis↑, xCT/SLC7A11↓, GSH↓, GPx4↓, Iron↑, lipid-P↑, ROS↑, eff↓, TumCP↓, TumCD↑,
5090- SSE,    Sodium Selenite Induces Ferroptosis in Non-small Cell Lung Cancer A549 Cells Via Reactive Oxygen Species (ROS)/Glutathione (GSH)/Glutathione Peroxidase4 (GPx4) Axis
- in-vitro, Lung, A549
TumCP↓, ROS↑, GSH↓, MMP↓, GPx4↓, Iron↑,

Showing Research Papers: 51 to 100 of 104
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 104

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   Catalase↓, 2,   Fenton↑, 11,   GPx↓, 3,   GPx4↓, 46,   GPx4↑, 1,   GSH↓, 32,   GSH↑, 1,   GSH↝, 1,   i-GSH↓, 1,   GSH/GSSG↓, 4,   GSR↓, 1,   H2O2↑, 3,   HO-1↓, 4,   HO-1↑, 9,   Iron↓, 9,   Iron↑, 56,   Iron↝, 4,   Iron∅, 1,   i-Iron↓, 2,   i-Iron↑, 11,   c-Iron↑, 1,   Keap1↓, 1,   Keap1↑, 1,   lipid-P↑, 34,   MDA↑, 25,   i-MDA↑, 2,   NADH↓, 1,   NADPH/NADP+↓, 1,   NFE2L2↑, 1,   NOX4↑, 1,   NRF2↓, 14,   NRF2↑, 8,   RNS↑, 1,   ROS↓, 6,   ROS↑, 72,   SOD↓, 4,   T-SOD↓, 1,   xCT/SLC7A11↓, 10,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 5,   Ferritin↑, 1,   FPN↝, 1,   FTH1↓, 4,   FTH1↑, 1,   FTL↑, 1,   IronCh↑, 1,   IronCh∅, 1,   LIP↑, 1,   Mets↑, 1,   NCOA4↑, 3,   NCOA4↝, 1,   SFXN2↓, 1,   Tf↓, 1,   Tf↑, 1,   TfR1/CD71↓, 2,   TfR1/CD71↑, 1,   TfR1/CD71↝, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ETC↓, 1,   mtDam↑, 8,   OXPHOS↓, 3,   SIRT3↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACSL4↑, 3,   ALDOA↓, 1,   AMPK↑, 6,   p‑AMPK↑, 1,   ATP↓, 4,   ECAR↓, 1,   ENO1↓, 1,   FASN↓, 1,   G6PD↓, 1,   GLS↓, 1,   GlucoseCon↓, 3,   Glycolysis↓, 6,   GSK‐3β↓, 1,   HK2↓, 2,   lactateProd↓, 4,   lactateProd↑, 1,   LDHA↓, 3,   MCT4↓, 1,   PDK1 / PDPK1↓, 1,   PFKP↓, 1,   PKM2↓, 2,   PKM2↑, 1,   Pyruv↓, 1,   SCD1↓, 1,   SLC1A5↓, 1,   SREBP2↓, 1,   TCA↓, 1,   Warburg↓, 2,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 1,   Apoptosis↑, 22,   BAX↑, 6,   Bax:Bcl2↑, 2,   Bcl-2↓, 5,   BIM↑, 1,   Casp↑, 2,   Casp3↑, 3,   cl‑Casp3↑, 2,   Casp8↑, 2,   Casp9↑, 1,   Cyt‑c↑, 4,   DR5↑, 3,   Fas↑, 1,   Ferroptosis↓, 2,   Ferroptosis↑, 61,   GranB/GZMB↝, 1,   MOMP↑, 1,   necrosis↑, 1,   p38↑, 3,   Perforin↝, 1,   Pyro↑, 2,   TumCD↑, 4,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 13,   p‑Akt↓, 1,   CaMKII ↓, 1,   cMET↓, 1,   ERK↓, 1,   ERK↑, 2,   p‑ERK↑, 1,   IκB↑, 1,   JAK↓, 2,   JAK2↓, 1,   JNK↑, 4,   p‑JNK↑, 1,   MAPK↓, 2,   MAPK↑, 2,   p‑MAPK↑, 1,   MARK4↓, 1,   mTOR↓, 11,   mTOR↑, 2,   p‑mTOR↓, 1,   p‑p70S6↓, 1,   P70S6K↑, 1,   PI3K↓, 6,   p‑PI3K↑, 1,   p‑PI3k/Akt/mTOR↓, 1,   PTEN↑, 1,   RET↓, 1,   STAT3↓, 7,   STAT3↑, 1,   p‑STAT3↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF4↑, 1,   ATFs↑, 1,   cMyc↓, 1,   DLEU1↓, 1,   DNMTs↓, 1,   HDAC↓, 1,   HDAC2↓, 1,   JPT1/HN1↓, 1,   LINC01116↓, 1,   miR-10b-5p↓, 1,   miR-155↓, 1,   miR-182-5p↓, 1,   miR-592↑, 1,   OCT4↓, 1,   other↓, 2,   other↝, 2,   SOX2↓, 2,   SOX4↓, 2,   tumCV↓, 7,   tumCV↑, 1,   USF1↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 1,   CHOP/DDIT3↑, 5,   eIF2α↓, 1,   ER Stress↑, 7,   Erlin1↑, 1,   GRP78/BiP↓, 1,   GRP78/BiP↑, 1,   HSP70/HSPA5↑, 1,   HSP90↓, 1,   PERK↑, 1,   UPR↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 1,   ATG7↑, 1,   autolysosome↑, 1,   Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 2,   LC3B↑, 1,   LC3II↑, 1,   LC3s↑, 1,   p62↓, 2,   p62↑, 1,   p‑p62↑, 1,   TumAuto↑, 11,   mt-TumAuto↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 5,   P53↓, 1,   P53↑, 7,   PARP↑, 1,   cl‑PARP↑, 1,   cl‑PARP↝, 1,   SIRT6↓, 1,   Telomerase↓, 1,   TOP2↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 3,   CDK2↓, 1,   CycB/CCNB1↓, 1,   CycB/CCNB1↑, 1,   cycD1/CCND1↓, 1,   Ki-67↓, 3,   mitA↑, 1,   P21↓, 1,   P21↑, 2,   p27/CDKN1B↓, 1,   p27/CDKN1B↑, 1,   p‑pRB↓, 1,   TumCCA↑, 17,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

p‑4E-BP1↓, 1,   CD133↓, 1,   CSCs↓, 6,   CSCsMark↓, 1,   Diff↑, 1,   FOSL1↑, 1,   GDF15↓, 1,   Gli1↓, 1,   IGF-1↓, 1,   Ki-67↓, 3,   Nanog↓, 3,   NOTCH1↓, 2,   Piezo1↑, 2,   TumCG↓, 18,   TumCP↓, 27,   Wnt↓, 7,  

Migration(tgid=13) ⓘ

AP-1↓, 2,   ATPase↓, 1,   BACH1↑, 1,   Ca+2↓, 1,   Ca+2↑, 2,   E-cadherin↑, 2,   EMT↓, 5,   MMP2↓, 3,   MMP9↓, 5,   MMPs↓, 1,   MUC1-C↓, 1,   N-cadherin↓, 2,   Sharpin↓, 1,   SMAD2↓, 1,   SMAD3↓, 1,   Snail↓, 1,   TGF-β1↓, 1,   THBS1↓, 1,   TIMP2↓, 1,   TumCI↓, 6,   TumCMig↓, 7,   TumMeta↓, 3,   uPA↓, 1,   Vim↓, 3,   β-catenin/ZEB1↓, 4,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 4,   EGR1↓, 1,   Hif1a↓, 5,   Hif1a↑, 1,   NO↓, 1,   REL↑, 1,   VEGF↓, 2,   VEGF↑, 1,  

Barriers & Transport(tgid=15) ⓘ

CellMemb↑, 1,   EPR↑, 1,   GLUT1↓, 3,   GLUT4↓, 1,   MMP↓, 12,   MPT↑, 1,   SLC12A5↓, 1,   TRPV1↝, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD44↓, 3,   CD8+↑, 1,   COX2/PTGS2↓, 1,   CXCR4↓, 1,   DR4↑, 1,   HMGB1↓, 1,   IL12↑, 1,   IL2↑, 1,   Imm↑, 5,   Imm↝, 1,   Inflam↓, 2,   pol-M1↑, 1,   M2 MC↓, 1,   MCP1/CCL2↓, 1,   MCT1↓, 1,   NF-kB↓, 5,   NF-kB↑, 1,   NK cell↑, 1,   PD-L1↓, 2,   SOCS-3↑, 1,   TLR1↑, 1,   TNF-α↑, 1,  

Cellular Microenvironment(tgid=17) ⓘ

pH↓, 1,   pH↝, 1,   i-pH↑, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AhR↓, 1,   AR↝, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABC↓, 1,   BioAv↓, 3,   BioAv↑, 3,   BioAv↝, 1,   BioEnh↑, 1,   ChemoSen↑, 22,   Dose?, 1,   Dose↝, 4,   eff↓, 12,   eff↑, 11,   eff↝, 2,   Half-Life↓, 1,   MDR1↓, 3,   P-gp/ABCB1↓, 2,   RadioS↑, 3,   selectivity↑, 11,   Synergy↑, 9,  

Clinical Biomarkers(tgid=22) ⓘ

AR↝, 1,   BMD↑, 1,   E6↓, 1,   E7↓, 1,   Ferritin↓, 5,   Ferritin↑, 1,   LDH↓, 1,   PD-L1↓, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 11,   antiCG↓, 1,   antiNeop↑, 1,   AntiTum↓, 1,   AntiTum↑, 2,   chemoP↑, 2,   hepatoP↑, 1,   neuroP↑, 1,   OS↑, 1,   QoL↑, 2,   radioP↑, 1,   RenoP↑, 1,   toxicity↓, 1,   toxicity↑, 1,   toxicity↝, 1,   TumVol↓, 5,   TumW↓, 5,  

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 1,   GutMicro↑, 1,  
Total Targets: 337

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↓, 1,   antiOx↑, 8,   Bil↓, 1,   Catalase↓, 1,   Catalase↑, 3,   Copper↓, 2,   Fenton↓, 2,   GPx↓, 1,   GPx↑, 7,   GPx4↓, 2,   GPx4↑, 4,   GSH↓, 2,   GSH↑, 6,   GSR↑, 1,   HDL↓, 1,   HO-1↓, 2,   HO-1↑, 2,   HO-1↝, 1,   Iron↓, 15,   Iron↑, 2,   Iron↝, 2,   Iron∅, 1,   i-Iron↓, 3,   i-Iron↑, 1,   lipid-P↓, 2,   lipid-P↑, 2,   MDA↓, 7,   MDA↑, 2,   NOX↓, 1,   NRF2↓, 2,   NRF2↑, 9,   ROS↓, 21,   ROS↑, 2,   i-ROS↑, 1,   SOD↓, 2,   SOD↑, 7,   TAC↑, 1,   TBARS↓, 1,   xCT/SLC7A11↓, 1,   xCT/SLC7A11↑, 2,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1,   Ferritin↑, 1,   FPN↑, 1,   FTH1↓, 1,   FTL↓, 1,   IronCh↑, 4,   NCOA4↝, 1,   TfR1/CD71↓, 2,   TfR1/CD71↑, 1,   Zn2+↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

mtDam↓, 3,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACSL4↓, 3,   ALAT↑, 1,   NADPH↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 7,   BAX↓, 2,   Bax:Bcl2↓, 1,   Bcl-2↓, 1,   Bcl-2↑, 1,   Casp3↓, 3,   Casp3↑, 1,   Ferroptosis↓, 7,   Ferroptosis↑, 1,   iNOS↓, 2,   p38↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↑, 1,   CREB↑, 1,   ERK↓, 1,   ERK↑, 1,   JNK↓, 2,   MAPK↓, 1,   PKA↑, 1,   PKCδ?, 1,   PTEN↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↓, 2,   other↑, 3,   other↝, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ER Stress↓, 1,   GRP78/BiP↓, 1,   IRE1↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

neuroG↑, 1,   Zn2+↓, 1,  

Migration(tgid=13) ⓘ

Ca+2↓, 1,   Ca+2↝, 1,   MMP9↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

Hif1a↓, 1,   NO↓, 2,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 4,   BBB↝, 1,   BBB∅, 2,   CLDN4↑, 1,   MMP↑, 1,   OCLN↑, 1,   TJ↑, 2,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,   HMGB1↓, 1,   IL17↓, 1,   IL1β↓, 3,   IL6↓, 4,   Inflam↓, 10,   NeuroI↓, 1,   NF-kB↓, 1,   NLRP3↓, 1,   RAGE↓, 1,   TNF-α↓, 3,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 2,   ADAM10↑, 1,   BDNF↑, 2,   PSD95↑, 3,   SNAP25↑, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 3,   Aβ42↓, 2,   BACE/β-secretase↝, 1,   tau↓, 1,   p‑tau↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 2,   BioAv↑, 2,   BioAv↝, 2,   ChemoSen↑, 1,   Dose?, 2,   Dose↝, 1,   eff↑, 4,   selectivity↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↑, 1,   anemia↓, 1,   AST↑, 1,   Bil↓, 1,   BUN↓, 1,   creat↓, 1,   Ferritin↓, 1,   Ferritin↑, 1,   HemoG↑, 1,   IL6↓, 4,   IRes↓, 1,   LDH↑, 1,   RAGE↓, 1,   RBC↑, 1,   Urea↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiTum↑, 1,   cardioP↑, 2,   cardioP∅, 1,   CardioT↓, 1,   chemoP↑, 2,   cognitive↑, 4,   hepatoP↓, 2,   hepatoP↑, 1,   Learn↑, 1,   memory↑, 1,   motorD↑, 1,   neuroP↑, 7,   OS↑, 1,   RenoP↑, 2,   Stroke↓, 3,   toxicity↓, 5,   toxicity↝, 2,   toxicity∅, 2,   Weight∅, 1,  

Infection & Microbiome(tgid=24) ⓘ

GutMicro↑, 2,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 1,  
Total Targets: 161

Scientific Paper Hit Count for: Iron, Iron
9 Artemisinin
6 Lactoferrin/Talactoferrin
6 Shikonin
5 Curcumin
5 Cisplatin
5 Matrine
4 Vitamin C (Ascorbic Acid)
4 Luteolin
4 salinomycin
4 Selenite (Sodium)
3 doxorubicin
3 phytic acid, Inositol hexakisphosphate
3 Isoliquiritigenin
3 Magnetic Fields
2 Disulfiram
2 Copper and Cu NanoParticles
2 ferumoxytol
2 Huperzine A/Huperzia serrata
2 Kaempferol
2 Licochalcone A
2 Mung Bean Sprouts
2 Myricetin
2 Quercetin
2 Rosmarinic acid
2 Sulforaphane (mainly Broccoli)
1 Astragalus
1 Allicin (mainly Garlic)
1 Alpha-Lipoic-Acid
1 Andrographis
1 Ashwagandha(Withaferin A)
1 Boswellia (frankincense)
1 brusatol
1 NTP, Non-Thermal Plasma,Cold Atmospheric Plasma
1 Carvacrol
1 Choline
1 Citric Acid
1 diet FMD Fasting Mimicking Diet
1 Diindolylmethane
1 EGCG (Epigallocatechin Gallate)
1 Fucoidan
1 Gallic acid
1 Ginkgo biloba
1 Ginkgetin
1 HydroxyCitric Acid
1 Honokiol
1 HydroxyTyrosol
1 Hyperoside
1 Isobavachalcone
1 isoorientin
1 Juglone
1 Metformin
1 Magnetic Field Rotating
1 Melatonin
1 magnetic nanoparticles
1 immunotherapy
1 Morin
1 Phenethyl isothiocyanate
1 Sulfasalazine
1 Spermidine
1 erastin
1 Aflavin-3,3′-digallate
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:160  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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