JAK2 Cancer Research Results

JAK2, Janus kinase 2: Click to Expand ⟱
Source: CGL-Driver Genes
Type: Oncogene
A tyrosine kinase that plays a crucial role in the signaling pathways of various cytokines and growth factors. It is particularly important in hematopoiesis (the formation of blood cells) and immune responses.

JAK2 plays a significant role in cancer biology, particularly in hematological malignancies, where its expression and activity are often upregulated. Increased JAK2 activity is generally associated with worse prognosis in many cancers, indicating its potential role in promoting tumor growth and survival.
Scientific Papers found: Click to Expand⟱
8526- Matr,    A Systematic Review of the Pharmacology, Toxicology and Pharmacokinetics of Matrine
- Review, Nor, NA
*AntiCan↑, *Inflam↓, *antiOx↑, *AntiViral↑, *Bacteria↓, *antiAll↑, *Analgesic↑, *hepatoP↑, *cardioP↑, *neuroP↑, *toxicity↝, p38↓, IL6↓, JAK2↓, STAT3↓, Casp↑, PI3K↓, Akt↓, mTOR↓, Beclin-1/ATG6↑, PCNA↓, Bcl-2↓, XIAP↑, VEGF↓, NF-kB↓, MMP2↓, MMP9↓, P-gp/ABCB1↓, survivin↓, OCT4↓, SOX2↓, p62↓, *TNF-α↓, *IL6↓, *HMGB1↓, *AntiArt↑, *NF-kB↓, *IL6↓, *IL8↓, *IL1β↓, *IL17↓, *TNF-α↓, *ROS↓, *NRF2?, *AST↓, *ALAT↓, *TGF-β↓, *α-SMA↓, *JAK2↑, *STAT3↑, *BioAv↝, *Half-Life↝, ChemoSen↑, ATP↓, ROS↑,
8628- MBZ,    Mebendazole induces apoptosis and inhibits migration via the reactive oxygen species-mediated STAT3 signaling downregulation in non-small cell lung cancer
- vitro+vivo, Lung, A549 - in-vitro, Lung, H460
TumCP↓, TumCMig↓, Apoptosis↑, ROS↑, p‑JAK2↓, p‑STAT3↓, eff↓, TumCG?, Bcl-xL↓, EMT↓, Snail↓, Twist↓,
8761- MeSA,    Methylseleninic Acid Suppresses Breast Cancer Growth via the JAK2/STAT3 Pathway
- in-vitro, BC, 4T1
TumCI↓, Apoptosis↑, Casp3↑, PARP1↑, BAX↑, JAK2↓, STAT3↓,
8859- MOR,    Morin inhibits STAT3 tyrosine 705 phosphorylation in tumor cells through activation of protein tyrosine phosphatase SHP1
- in-vitro, Melanoma, U266 - in-vitro, BC, MCF7 - in-vitro, SCC, SCC4 - in-vitro, BC, MCF-10AT
STAT3↓, Src↓, JAK1↓, JAK2↓, PIAS-3↑, ChemoSen↑, SHP1↑, XIAP↓, cFLIP↓, Mcl-1↓, survivin↓, Bcl-2↓, Bcl-xL↓, IAP2/BIRC3↓, Casp8↑, Casp9↑, Casp3↑, cl‑PARP↑, selectivity↑,
8918- MP,  Cisplatin,    Mucuna pruriens (L.) DC chemo sensitize human breast cancer cells via downregulation of prolactin-mediated JAK2/STAT5A signaling
- in-vitro, BC, T47D - in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231 - in-vitro, BC, MDA-MB-231
Dose?, TumCP↓, DNAdam↑, TumCCA↑, PRL↓, JAK2↓, STAT5↓, cycD1/CCND1↓, ChemoSen↑,
8777- MSM,  Tam,    The combination of methylsulfonylmethane and tamoxifen inhibits the Jak2/STAT5b pathway and synergistically inhibits tumor growth and metastasis in ER-positive breast cancer xenografts
- in-vitro, BC, MCF7 - in-vitro, BC, T47D
tumCV↓, TumCMig↓, JAK2↓, STAT5↓, ChemoSen↑, cycD1/CCND1↓, VEGF↓, IGF-1↓, IGF-1R↓, MMP2↓, MMP3↓, MMP9↓, TumVol↓, STAT3↓,
6487- Nimb,    Anticancer properties of nimbolide and pharmacokinetic considerations to accelerate its development
- Review, Var, NA
TumCP↓, Apoptosis↓, TumMeta↑, angioG↓, *antiOx↑, *eff↑, Apoptosis↑, MOMP↑, CDK1↓, TumCCA↑, MAPK↓, JAK2↓, STAT3↓, PI3K↓, Akt↓, TumCP↓, *NRF2↑, NF-kB↓, GSK‐3β↑, Wnt↓, β-catenin/ZEB1↓, chemoPv↑, Bcl-xL↓, Bcl-2↓, survivin↓, Cyt‑c↑, BAX↑, BID↑, cl‑Casp↑, P53↑, DR5↑, DR4↑, ROS↑, lipid-P↑, MDA↑, MMP2↓, MMP9↓, uPA↓, ICAM-1↓, CXCR4↓, CXCR2↓, angioG↓, BBB↑,
5186- PEITC,    Phenethyl Isothiocyanate inhibits STAT3 activation in prostate cancer cells
- in-vitro, Pca, DU145 - in-vitro, Pca, LNCaP
TumCP↓, TumCCA↑, STAT3↓, p‑JAK2↓, eff↓, TumCCA↑, AR↓, ROS↑,
2948- PL,    The promising potential of piperlongumine as an emerging therapeutics for cancer
- Review, Var, NA
tumCV↓, TumCP↓, TumCI↓, angioG↓, EMT↓, TumMeta↓, *hepatoP↑, *lipid-P↓, *GSH↑, cardioP↑, CycB/CCNB1↓, cycD1/CCND1↓, CDK2↓, CDK1↓, CDK4↓, CDK6↓, PCNA↓, Akt↓, mTOR↓, Glycolysis↓, NF-kB↓, IKKα↓, JAK1↓, JAK2↓, STAT3↓, ERK↓, cFos↓, Slug↓, E-cadherin↑, TOP2↓, P53↑, P21↑, Bcl-2↓, BAX↑, Casp3↑, Casp7↑, Casp8↑, p‑HER2/EBBR2↓, HO-1↑, NRF2↑, BIM↑, p‑FOXO3↓, Sp1/3/4↓, cMyc↓, EGFR↓, survivin↓, cMET↓, NQO1↑, SOD2↑, TrxR↓, MDM2↓, p‑eIF2α↑, ATF4↑, CHOP/DDIT3↑, MDA↑, Ki-67↓, MMP9↓, Twist↓, SOX2↓, Nanog↓, OCT4↓, N-cadherin↓, Vim↓, Snail↓, TumW↓, TumCG↓, HK2↓, RB1↓, IL6↓, IL8↓, SOD1↑, RadioS↑, ChemoSen↑, toxicity↓, Sp1/3/4↓, GSH↓, SOD↑,
5160- PLB,  VitK3,    Plumbagin, Vitamin K3 Analogue, Suppresses STAT3 Activation Pathway through Induction of Protein Tyrosine Phosphatase, SHP-1: Potential Role in Chemosensitization
- in-vitro, Melanoma, U266
STAT3↓, cSrc↓, JAK1↓, JAK2↓, SHP1↑, cycD1/CCND1↓, Bcl-xL↓, VEGF↓, Casp3↑, cl‑PARP↑, TumCCA↑, ChemoSen↑,
1238- PTS,    Pterostilbene suppresses gastric cancer proliferation and metastasis by inhibiting oncogenic JAK2/STAT3 signaling: In vitro and in vivo therapeutic intervention
- in-vitro, GC, NA - in-vivo, NA, NA
TumCCA↑, TumCP↓, TumCMig↓, TumCI↓, TumVol↓, TumW↓, Weight∅, JAK2↓, STAT3↓,
4686- QC,    Quercetin suppresses endometrial cancer stem cells via ERα-mediated inhibition of STAT3 signaling
- in-vitro, EC, EMN8 - in-vitro, EC, EMN21
CSCs↓, ALDH1A1↓, cMyc↓, Nanog↓, OCT4↓, STAT3↓, JAK2↓, STAT3↓, eff↑,
3361- QC,    Quercetin ameliorates testosterone secretion disorder by inhibiting endoplasmic reticulum stress through the miR-1306-5p/HSD17B7 axis in diabetic rats
- in-vivo, Nor, NA - in-vitro, NA, NA
*BG↓, *ROS↓, *SOD↑, *MDA↓, *ER Stress↓, *iNOS↓, *CHOP/DDIT3↓, *GRP78/BiP↓, *antiOx↓, *Inflam↓, *JAK2↑, *STAT3?,
3380- QC,    Quercetin as a JAK–STAT inhibitor: a potential role in solid tumors and neurodegenerative diseases
- Review, Var, NA - Review, Park, NA - Review, AD, NA
JAK↓, STAT↓, Inflam↓, NO↓, COX2/PTGS2↓, CRP↓, selectivity↑, *neuroP↑, STAT3↓, cycD1/CCND1↓, MMP2↓, STAT4↓, JAK2↓, TumCP↓, Diff↓, *Synergy↑, *IL6↓, *TNF-α↓, *IL1β↓, *Aβ↓,
3072- RES,    Resveratrol ameliorates glioblastoma inflammatory response by reducing NLRP3 inflammasome activation through inhibition of the JAK2/STAT3 pathway
- in-vitro, GBM, LN229 - in-vitro, GBM, U87MG
tumCV↓, TumCP↓, TumCMig↓, Apoptosis↑, NLRP3↓, JAK2↓, STAT3↓, IL1β↓, IL18↓, IL6↓, TNF-α↓, Inflam↓,
8778- SFN,    Sulforaphane inhibits constitutive and interleukin-6-induced activation of signal transducer and activator of transcription 3 in prostate cancer cells
- in-vitro, Pca, DU145 - in-vitro, Pca, LNCaP
tumCV↓, IL6↓, STAT3↓, Dose↝, JAK2↓, Bcl-2↓, cycD1/CCND1↓, survivin↓, DNAdam↑, chemoPv↑,
1464- SFN,    d,l-Sulforaphane Induces ROS-Dependent Apoptosis in Human Gliomablastoma Cells by Inactivating STAT3 Signaling Pathway
- in-vitro, GBM, NA
Apoptosis↑, Casp3↑, BAX↑, Bcl-2↓, ROS↑, p‑STAT3↓, JAK2↓, eff↓,
3323- SIL,    Anticancer therapeutic potential of silibinin: current trends, scope and relevance
- Review, Var, NA
Inflam↓, angioG↓, antiOx↑, TumMeta↓, TumCP↓, TumCCA↑, TumCD↑, α-SMA↓, p‑Akt↓, p‑STAT3↓, COX2/PTGS2↓, IL6↓, MMP2↓, HIF-1↓, Snail↓, Slug↓, Zeb1↓, NF-kB↓, p‑EGFR↓, JAK2↓, PI3K↓, PD-L1↓, VEGF↓, CDK4↓, CDK2↓, cycD1/CCND1↓, E2Fs↓,
978- SIL,    A comprehensive evaluation of the therapeutic potential of silibinin: a ray of hope in cancer treatment
- Review, Var, NA
PI3K↓, Akt↓, NF-kB↓, Wnt/(β-catenin)↓, MAPK↓, TumCP↓, TumCCA↑, Apoptosis↑, p‑EGFR↓, JAK2↓, STAT5↓, cycD1/CCND1↓, hTERT/TERT↓, AP-1↓, MMP9↓, miR-21↓, miR-155↓, Casp9↑, BID↑, ERK↓, Akt2↓, DNMT1↓, P53↑, survivin↓, Casp3↑, ROS↑,
3047- SK,    Shikonin suppresses colon cancer cell growth and exerts synergistic effects by regulating ADAM17 and the IL-6/STAT3 signaling pathway
- in-vitro, CRC, HCT116 - in-vitro, CRC, SW48
TumCG↓, p‑STAT3↓, ADAM17↓, Apoptosis↑, Casp3↑, cl‑PARP↑, cycD1/CCND1↓, cycE/CCNE↓, TumCCA↑, JAK1?, p‑JAK1↓, p‑JAK2↓, p‑eIF2α↑, eff↓, ROS↑, IL6↓,
2083- TQ,    Thymoquinone inhibits proliferation in gastric cancer via the STAT3 pathway in vivo and in vitro
- in-vitro, GC, HGC27 - in-vitro, GC, BGC-823 - in-vitro, GC, SGC-7901 - in-vivo, NA, NA
p‑STAT3↓, JAK2↓, c-Src↓, Bcl-2↓, cycD1/CCND1↓, survivin↓, VEGF↓, Casp3?, Casp7?, Casp9?, *toxicity∅, TumVol↓,
3412- TQ,    Thymoquinone induces oxidative stress-mediated apoptosis through downregulation of Jak2/STAT3 signaling pathway in human melanoma cells
- in-vitro, Melanoma, SK-MEL-28 - in-vivo, NA, NA
Apoptosis↑, JAK2↓, STAT3↓, cycD1/CCND1↓, survivin↓, ROS↑, eff↓,
3411- TQ,    Anticancer and Anti-Metastatic Role of Thymoquinone: Regulation of Oncogenic Signaling Cascades by Thymoquinone
- Review, Var, NA
p‑STAT3↓, cycD1/CCND1↓, JAK2↓, β-catenin/ZEB1↓, cMyc↓, MMP7↓, MET↓, p‑Akt↓, p‑mTOR↓, CXCR4↓, Bcl-2↓, BAX↑, ROS↑, Cyt‑c↑, Twist↓, Zeb1↓, E-cadherin↑, p‑p38↑, p‑MAPK↑, ERK↑, eff↑, ERK↓, TumCP↓, TumCMig↓, TumCI↓,
3414- TQ,    Thymoquinone induces apoptosis through inhibition of JAK2/STAT3 signaling via production of ROS in human renal cancer Caki cells
- in-vitro, RCC, Caki-1
tumCV↓, Apoptosis↑, P53↑, BAX↑, Cyt‑c↑, cl‑Casp9↑, cl‑Casp3↑, cl‑PARP↑, Bcl-2↓, Bcl-xL↓, p‑STAT3↓, p‑JAK2↓, STAT3↓, survivin↓, cycD1/CCND1↓, ROS↑, eff↓,
3422- TQ,    Thymoquinone, as a Novel Therapeutic Candidate of Cancers
- Review, Var, NA
selectivity↑, P53↑, PTEN↑, NF-kB↓, PPARγ↓, cMyc↓, Casp↑, *BioAv↓, CompStab↝, Synergy↑, survivin↓, Bcl-xL↓, Bcl-2↓, Akt↓, BAX↑, cl‑PARP↑, CXCR4↓, MMP9↓, VEGFR2/KDR/Flk1↓, Ki-67↓, COX2/PTGS2↓, JAK2↓, cSrc↓, Apoptosis↑, p‑STAT3↓, cycD1/CCND1↓, Casp3↑, Casp7↑, Casp9↑, N-cadherin↓, Vim↓, Twist↓, E-cadherin↑, ChemoSen↑, Synergy↑, EMT↓, ROS↑, DNMT1↓, Synergy↑, EZH2↓, hepatoP↑, Zeb1↓, RadioS↑, HDAC↓, HDAC1↓, HDAC2↓, HDAC3↓, *NAD↑, *SIRT1↑, SIRT1↓, *Inflam↓, *CRP↓, *TNF-α↓, *IL6↓, *IL1β↓, *Synergy↑, *MDA↓, *NO↓, *GSH↑, *SOD↑, *Catalase↑, *GPx↑, PI3K↓, mTOR↓,
3427- TQ,    Chemopreventive and Anticancer Effects of Thymoquinone: Cellular and Molecular Targets
- in-vitro, Var, NA
ROS⇅, Fas↑, DR5↑, TRAIL↑, Casp3↑, Casp8↑, Casp9↑, P53↑, mTOR↓, Bcl-2↓, BID↓, CXCR4↓, JNK↑, p38↑, MAPK↑, LC3II↑, ATG7↑, Beclin-1/ATG6↑, AMPK↑, PPARγ↑, eIF2α↓, P70S6K↓, VEGF↓, ERK↓, NF-kB↓, XIAP↓, survivin↓, p65↓, DLC1↑, FOXO↑, TET2↑, CYP1B1↑, UHRF1↓, DNMT1↓, HDAC1↓, IL2↑, IL1↓, IL6↓, IL10↓, IL12↓, TNF-α↓, iNOS↓, COX2/PTGS2↓, 5LO↓, AP-1↓, PI3K↓, Akt↓, cMET↓, VEGFR2/KDR/Flk1↓, CXCL1↓, ITGA5↓, Wnt↓, β-catenin/ZEB1↓, GSK‐3β↓, Myc↓, cycD1/CCND1↓, N-cadherin↓, Snail↓, Slug↓, Vim↓, Twist↓, Zeb1↓, MMP2↓, MMP7↓, MMP9↓, JAK2↓, STAT3↓, NOTCH↓, cycA1/CCNA1↓, CDK2↓, CDK4↓, CDK6↓, CDC2↓, CDC25↓, Mcl-1↓, E2Fs↓, p16↑, p27/CDKN1B↑, P21↑, ChemoSen↑,
3573- TQ,    Chronic diseases, inflammation, and spices: how are they linked?
- Review, Var, NA
NF-kB↓, XIAP↓, PI3K↓, Akt↓, STAT3↓, JAK2↓, cSrc↓, PCNA↓, MMP2↓, ERK↓, Ki-67↓, Bcl-2↓, VEGF↓, p65↓, COX2/PTGS2↓, MMP9↓, *antiAll↑, *Eos↓, *CD31/PECAM-1↓, *α-SMA↓,

Showing Research Papers: 51 to 77 of 77
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 77

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   Catalase↓, 1,   GPx4↓, 1,   GSH↓, 4,   HO-1↓, 1,   HO-1↑, 3,   Iron↑, 1,   lipid-P↑, 2,   MDA↑, 3,   NQO1↓, 1,   NQO1↑, 2,   NRF2↓, 2,   NRF2↑, 1,   PrxII↓, 1,   PYCR1↓, 1,   ROS↑, 30,   ROS⇅, 1,   SOD↓, 2,   SOD↑, 1,   SOD1↑, 1,   SOD2↓, 1,   SOD2↑, 1,   TrxR↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC2↓, 2,   CDC25↓, 1,   mtDam↑, 1,   PINK1↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 1,   ALAT↓, 1,   AMPK↑, 3,   AMPK↝, 1,   ATP↓, 3,   CAIX/CA9↓, 1,   GlucoseCon↑, 1,   Glycolysis↓, 5,   GSK‐3β↓, 1,   GSK‐3β↑, 1,   Histones↑, 1,   HK2↓, 2,   PFK1↓, 1,   PKM2↓, 1,   Pyruv↓, 1,   SIRT1↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis?, 1,   Apoptosis↓, 2,   Apoptosis↑, 26,   BAX↑, 10,   BAX∅, 1,   Bax:Bcl2↑, 2,   Bcl-2↓, 21,   Bcl-2↑, 1,   Bcl-2∅, 1,   Bcl-xL↓, 11,   Bcl-xL∅, 1,   BID↓, 1,   BID↑, 2,   BIM↑, 1,   Casp↑, 7,   cl‑Casp↑, 1,   Casp3?, 1,   Casp3↑, 21,   cl‑Casp3↑, 4,   Casp7?, 1,   Casp7↑, 2,   Casp8↑, 7,   cl‑Casp8↑, 3,   proCasp8↑, 1,   Casp9?, 1,   Casp9↑, 9,   cl‑Casp9↑, 1,   cFLIP↓, 1,   Cyt‑c↑, 6,   Diablo↑, 1,   DR5↑, 2,   Fas↑, 1,   Ferroptosis↑, 1,   GranB/GZMB↑, 1,   GranB/GZMB↝, 1,   IAP1↓, 1,   IAP2/BIRC3↓, 1,   iNOS↓, 1,   Mcl-1↓, 7,   MDM2↓, 1,   MOMP↑, 1,   p38↓, 1,   p38↑, 2,   p‑p38↑, 1,   Perforin↑, 1,   Perforin↝, 1,   survivin↓, 17,   TRAIL↑, 1,   TumCD↑, 1,   XIAP↓, 7,   XIAP↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 12,   Akt↑, 2,   p‑Akt↓, 3,   Akt2↓, 1,   CK2↓, 1,   cMET↓, 2,   cSrc↓, 8,   EGFR↓, 6,   p‑EGFR↓, 2,   ERK↓, 9,   ERK↑, 3,   FGFR1↓, 1,   HER2/EBBR2↓, 1,   p‑HER2/EBBR2↓, 1,   IGF-1R↓, 1,   IKKα↓, 1,   JAK↓, 1,   p‑JAK↓, 1,   JAK1?, 1,   JAK1↓, 8,   p‑JAK1↓, 2,   JAK2↓, 59,   p‑JAK2↓, 9,   p‑JAK3↓, 1,   JNK↑, 2,   MAPK↓, 2,   MAPK↑, 1,   p‑MAPK↑, 1,   MEK↓, 1,   mTOR↓, 9,   mTOR↝, 1,   p‑mTOR↓, 2,   P70S6K↓, 1,   PI3K↓, 10,   p‑PI3K↓, 1,   PIAS-3↑, 1,   PTEN↑, 5,   Raf↓, 1,   RAS↓, 1,   p‑S6K↓, 1,   SHP1↑, 3,   Sp1/3/4↓, 4,   Src↓, 2,   c-Src↓, 1,   STAT↓, 2,   p‑STAT2↓, 1,   STAT3↓, 49,   p‑STAT3↓, 16,   STAT4↓, 1,   STAT5↓, 6,   p‑STAT5↓, 1,   STAT6↓, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF4↑, 1,   cMyc↓, 8,   DNMT1↓, 5,   EZH2↓, 2,   FOXO↑, 1,   p‑FOXO3↓, 1,   p‑H3↓, 1,   HDAC↓, 1,   HDAC1↓, 2,   HDAC2↓, 1,   HDAC3↓, 1,   miR-148a↑, 1,   miR-155↓, 1,   miR-21↓, 3,   miR-27a-3p↓, 1,   miR-301a-3p↓, 1,   miR-34a↑, 1,   Myc↓, 1,   n-MYC↓, 1,   OCT4↓, 5,   other↝, 1,   PhotoS↑, 1,   SOX2↓, 5,   SOX9?, 1,   tumCV↓, 10,   UTF1↑, 1,   ZBTB10↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,   CHOP/DDIT3↑, 1,   eIF2α↓, 1,   p‑eIF2α↑, 2,   GRP78/BiP↓, 1,   HSP90↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG7↑, 1,   Beclin-1/ATG6↑, 2,   LC3II↓, 1,   LC3II↑, 3,   p62↓, 2,   p62↑, 1,   PARK2↑, 1,   TumAuto⇅, 1,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 1,   BRCA1↑, 1,   DNAdam↑, 7,   hTERT/TERT↓, 1,   p16↑, 2,   P53↓, 1,   P53↑, 10,   PARP↑, 1,   cl‑PARP↑, 14,   PARP1↑, 1,   PCNA↓, 3,   Telomerase↓, 2,   TOP2↓, 1,   TP53↑, 2,   UHRF1↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 2,   CDK2↓, 5,   CDK4↓, 8,   CDK6↓, 4,   CHK1↑, 1,   Chk2↑, 1,   cycA1/CCNA1↓, 2,   CycB/CCNB1↓, 2,   cycD1/CCND1↓, 25,   CycD3↓, 1,   cycE/CCNE↓, 5,   E2Fs↓, 2,   Ki-67↓, 6,   P21↑, 6,   p27/CDKN1B↑, 4,   RB1↓, 1,   TumCCA↑, 26,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH1A1↓, 1,   CD133↓, 1,   cFos↓, 1,   CSCs↓, 5,   Diff↓, 2,   Gli1↓, 1,   IGF-1↓, 1,   Ki-67↓, 6,   p‑mTORC1↓, 1,   Nanog↓, 4,   Nestin↓, 1,   NOTCH↓, 2,   NOTCH1↓, 1,   PTCH1↓, 1,   p‑STAT1↓, 1,   TumCG?, 1,   TumCG↓, 16,   TumCP↓, 24,   tyrosinase↓, 1,   Wnt↓, 3,   Wnt/(β-catenin)↓, 1,  

Migration(tgid=13) ⓘ

AP-1↓, 2,   DLC1↑, 1,   E-cadherin↓, 1,   E-cadherin↑, 4,   EMT↓, 9,   Fibronectin↓, 1,   GLI2↓, 1,   ITGA5↓, 1,   LAMs↓, 1,   MET↓, 1,   MMP2↓, 16,   MMP3↓, 1,   MMP7↓, 2,   MMP9↓, 19,   MMPs↓, 3,   N-cadherin↓, 4,   ROCK1↓, 1,   Slug↓, 3,   Snail↓, 4,   TGF-β↓, 3,   TumCI↓, 14,   TumCMig↓, 11,   TumCMig↑, 1,   TumMeta↓, 7,   TumMeta↑, 1,   Twist↓, 5,   uPA↓, 2,   Vim↓, 4,   Zeb1↓, 4,   α-SMA↓, 2,   β-catenin/ZEB1↓, 5,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 11,   CD31/PECAM-1↓, 1,   HIF-1↓, 3,   Hif1a↓, 5,   NO↓, 1,   VEGF↓, 22,   VEGFR2/KDR/Flk1↓, 3,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 2,   GLUT4↓, 1,   MMP↓, 5,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CCR7↓, 1,   COX2/PTGS2↓, 12,   CXCL1↓, 1,   CXCL12↓, 1,   CXCR2↓, 1,   CXCR4↓, 5,   DR4↑, 1,   ICAM-1↓, 1,   IL1↓, 1,   IL10↓, 1,   IL12↓, 1,   IL18↓, 1,   IL1β↓, 3,   IL2↑, 1,   IL6↓, 15,   IL8↓, 3,   Inflam↓, 9,   M2 MC↓, 1,   MCP1/CCL2↓, 2,   MIP2↓, 1,   NF-kB↓, 18,   NLRP3↓, 1,   NLRP3↑, 1,   p65↓, 2,   PD-L1↓, 4,   PGE2↓, 4,   SOCS-3↑, 1,   TNF-α↓, 5,  

Cellular Microenvironment(tgid=17) ⓘ

ADAM17↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 2,   PPARγ↓, 1,   PPARγ↑, 2,   PRL↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 3,   BioAv↑, 4,   BioAv↝, 1,   ChemoSen↑, 24,   CompStab↓, 1,   CompStab↝, 1,   CYP1B1↑, 1,   Dose?, 3,   Dose↓, 1,   Dose↑, 1,   Dose↝, 3,   eff↓, 7,   eff↑, 3,   eff↝, 2,   Half-Life↝, 2,   MRP1/ABCC1↓, 1,   NAT↓, 1,   P-gp/ABCB1↓, 1,   RadioS↑, 8,   selectivity↑, 8,   Synergy↑, 11,   TET2↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AFP↑, 1,   ALAT↓, 1,   ALP↓, 1,   AR↓, 2,   AST↓, 1,   BRCA1↑, 1,   CRP↓, 1,   EGFR↓, 6,   p‑EGFR↓, 2,   EZH2↓, 2,   HER2/EBBR2↓, 1,   p‑HER2/EBBR2↓, 1,   hTERT/TERT↓, 1,   IL6↓, 15,   LDH↓, 1,   Myc↓, 1,   PD-L1↓, 4,   TP53↑, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 6,   AntiTum↑, 1,   cardioP↑, 1,   chemoP↑, 2,   chemoPv↑, 3,   ChemoSideEff↓, 1,   hepatoP↑, 3,   QoL↑, 1,   radioP↑, 1,   toxicity↓, 4,   toxicity⇅, 1,   toxicity↝, 2,   TumVol↓, 5,   TumW↓, 4,   Weight∅, 1,  

Infection & Microbiome(tgid=24) ⓘ

GutMicro↑, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 1,  
Total Targets: 371

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 2,   antiOx↑, 9,   Catalase↑, 5,   Fenton↓, 1,   GPx↑, 2,   GSH↑, 4,   HO-1↑, 2,   Keap1↓, 1,   lipid-P↓, 5,   MDA↓, 8,   MPO↓, 1,   NOX↓, 1,   NOX4↓, 1,   NRF2?, 1,   NRF2↓, 1,   NRF2↑, 4,   RNS↓, 1,   ROS↓, 14,   SOD↑, 7,   TBARS↓, 1,   TOS↓, 1,   uricA↓, 1,   VitE↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

mtDam↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 2,   AMPK↑, 2,   Buty↑, 1,   NAD↑, 1,   NADPH↓, 1,   SCFAs↑, 1,   SIRT1↑, 2,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 2,   BAX↓, 1,   Bcl-2↓, 1,   Bcl-2↑, 1,   Bcl-xL↑, 1,   Casp3↓, 2,   Casp3↑, 1,   Casp9↓, 1,   iNOS↓, 3,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 1,   Akt↑, 1,   ERK↑, 1,   p‑JAK1↓, 1,   JAK2↓, 4,   JAK2↑, 4,   p‑JAK2↓, 2,   JNK↓, 1,   MAPK↓, 3,   PI3K↓, 1,   PI3K↑, 1,   STAT3?, 1,   STAT3↓, 3,   STAT3↑, 3,   p‑STAT3↓, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF4↓, 1,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,   p‑eIF2α↓, 1,   ER Stress↓, 3,   GRP78/BiP↓, 2,   HSP70/HSPA5↑, 1,   IRE1↓, 1,   p‑PERK↓, 1,   UPR↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 2,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

neuroG↑, 1,   p‑STAT1↓, 1,   TumCP↓, 1,  

Migration(tgid=13) ⓘ

COL1↓, 1,   COL1↑, 1,   Fibrosis↓, 1,   MMP9↓, 1,   Sema3A/PlexinA1↑, 1,   TGF-β↓, 1,   TGF-β↑, 1,   TGF-β1↓, 1,   TumCI↓, 1,   TumCMig↓, 1,   α-SMA↓, 3,   α-SMA↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↑, 1,   CD31/PECAM-1↓, 1,   NO↓, 3,   NO↑, 1,   VEGF↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB∅, 2,   IBI↑, 1,   MMP↑, 1,   TJ↑, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD25+↑, 1,   CD4+↑, 1,   CD8+↑, 1,   COX2/PTGS2↓, 1,   Eos↓, 1,   FOXP3↑, 1,   HMGB1↓, 3,   ICAM-1↓, 1,   IL10↑, 1,   IL17↓, 1,   IL1β↓, 7,   IL4↑, 1,   IL6↓, 9,   IL8↓, 1,   Inflam↓, 14,   M2 MC↑, 1,   MCP1/CCL2↓, 1,   NeuroI↓, 1,   NF-kB↓, 4,   NLRP3↓, 3,   PGE2↓, 1,   RAGE↓, 1,   TNF-α↓, 8,   TNF-α↑, 1,   Treg lymp↝, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

PSD95↑, 1,   SNAP25↑, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 3,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

GLP-1R↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 6,   BioAv↑, 1,   BioAv↝, 1,   Dose↓, 1,   Dose↑, 1,   Dose↝, 2,   eff↑, 3,   Half-Life↝, 2,   Synergy↑, 2,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 2,   AST↓, 2,   BG↓, 1,   BloodF↑, 1,   BMD↑, 2,   CRP↓, 1,   IL6↓, 9,   RAGE↓, 1,   SpO2↑, 1,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 1,   antiAll↑, 3,   AntiArt↑, 1,   AntiCan↓, 1,   AntiCan↑, 1,   AntiDiabetic↑, 1,   cardioP↑, 4,   cognitive↑, 2,   diuretic↑, 1,   hepatoP↑, 5,   Learn↑, 1,   memory↑, 2,   neuroP↑, 7,   OS↑, 1,   RenoP↑, 1,   Stroke↓, 2,   toxicity↓, 1,   toxicity↝, 1,   toxicity∅, 1,   Weight↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiViral↑, 1,   Bacteria↓, 2,   GutMicro↑, 1,  
Total Targets: 160

Scientific Paper Hit Count for: JAK2, Janus kinase 2
7 Thymoquinone
5 Cucurbitacin
4 Baicalein
4 Curcumin
3 Apigenin (mainly Parsley)
3 Berberine
3 Quercetin
2 Cisplatin
2 Chemotherapy
2 Boron
2 Celastrol
2 Gemcitabine (Gemzar)
2 Emodin
2 Ferulic acid
2 Formononetin
2 Ginkgetin
2 Luteolin
2 Sulforaphane (mainly Broccoli)
2 Silymarin (Milk Thistle) silibinin
1 Artemisinin
1 Betulinic acid
1 Brucea javanica
1 brusatol
1 Carvacrol
1 Sorafenib (brand name Nexavar)
1 chaetocin
1 Crocetin
1 Fucoidan
1 Gallic acid
1 Garcinol
1 Geraniol
1 Ginger/6-Shogaol/Gingerol
1 Hydrogen Gas
1 Honokiol
1 Isoliquiritigenin
1 Ivermectin
1 Lasiodin
1 Magnolol
1 Matrine
1 mebendazole
1 methylseleninic acid
1 Morin
1 Mucuna pruriens/Velvet Bean
1 Methylsulfonylmethane
1 tamoxifen
1 Nimbolide
1 Phenethyl isothiocyanate
1 Piperlongumine
1 Plumbagin
1 VitK3,menadione
1 Pterostilbene
1 Resveratrol
1 Shikonin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:164  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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