antiAll Cancer Research Results

antiAll, antiallergic/antiasmatic: Click to Expand ⟱
Source:
Type:

Antiallergic Activity - Suppression of Allergic Responses

Type: Therapeutic effect / immune phenotype / functional outcome

Function: Antiallergic activity refers to suppression of allergic sensitization, mast-cell or basophil activation, IgE-mediated signaling, eosinophilic inflammation, histamine and leukotriene release, airway inflammation, or other manifestations of hypersensitivity.

Asthma: ↓ Allergic response is favorable. Increased antiallergic activity corresponds to reduced IgE/FcεRI signaling, mast-cell degranulation, eosinophil recruitment, type-2 cytokine signaling, mucus production, bronchoconstriction, and airway hyperresponsiveness.

Favorable Direction: ↑ Antiallergic activity = beneficial.
Scientific Papers found: Click to Expand⟱
8278- LE,    Glycyrrhiza glabra (Licorice): A Comprehensive Review on Its Phytochemistry, Biological Activities, Clinical Evidence and Toxicology
- Review, Var, NA
*Ingr↝, *AntiCan↑, *AntiDiabetic↑, *AntiBio↑, *Inflam↓, *antiAll↑, *hepatoP↑, *cough?, *SoreThr?, *toxicity↝, *cardioP↑, *BioAv↝, *PGE2↓, *COX2/PTGS2↓, *AntiAg↑, *ROS↓, *NLRP3↓, *NF-kB↓, *AP-1↓, TumCCA↑, Apoptosis↑, TumMeta↑, *Dose↝, *Dose↝, Ingr↝, TumAuto↑, LC3II↑, PI3K↓, Akt↓, mTOR↓, *cognitive↑, *BloodF↑, ChemoSen↑, ROS↓, *chemoP↑, ROS↑, tumCV↓, MMP↓, *AntiBio↑, *toxicity↝,
8377- LT,    Luteolin: exploring its therapeutic potential and molecular mechanisms in pulmonary diseases
- Review, Asthma, NA
*PI3K↑, *Akt↑, *Inflam↓, *ROS↓, *BioAv↓, *RenoP↑, *cardioP↑, *neuroP↑, *antiAll↑, *AntiDiabetic↑, *hepatoP↑, *AntiThr↑, *toxicity↓, *IL10↓, *Sepsis↓, *TNF-α↓, *ROS↓, *GSH↑, *Catalase↑, *SOD↑, *MDA↓, *lipid-P↓, *IL4↓, *IL5↓, *PGE2↓, *PI3K↑, *Akt↑, *mTOR↑, *Beclin-1/ATG6↓, *Mucositis↓, *PLA2↓, STAT3↓, PD-L1↓, miR-34a↓, Casp3↑, Casp9↑, Bcl-2↓, BAX↑, Bax:Bcl2↑, Apoptosis↑, ROS↑, EMT↓, E-cadherin↓, DR5↑, LIMK1↓, Pain↓,
8398- LT,    Luteolin: Nature's promising warrior against Alzheimer's and Parkinson's disease
- Review, AD, NA - Review, Park, NA
*antiOx↑, *Inflam↓, *AntiBio↑, *AntiCan↑, *hepatoP↑, *neuroP↑, *cardioP↑, *neuroG↑, *BBB↑, *ROS↓, *AChE↓, *p‑T-cadherin↓, *Aβ↓, *memory↑, *TNF-α↓, *IL1β↓, *MCP1/CCL2↓, *RANTES↓, *BioAv↑, *Half-Life↝, *toxicity↓, *BACE/β-secretase↓, *Aβ42↓, *COX2/PTGS2↓, *Bcl-2↓, *Casp3↓, *BAX↓, *GSTs↓, *lipid-P↓, *Casp3↓, *Casp9↓, *memory↑, *GSK‐3β↓, *ChAT↑, *SOD↑, *GPx↑, *MDA↓, *ER Stress↓, *GRP78/BiP↓, *NRF2↑, *motorD↑, *antiAll↑,
2916- LT,    Antioxidative and Anticancer Potential of Luteolin: A Comprehensive Approach Against Wide Range of Human Malignancies
- Review, Var, NA - Review, AD, NA - Review, Park, NA
proCasp9↓, CDC2↓, CycB/CCNB1↓, Casp9↑, Casp3↑, Cyt‑c↑, cycA1/CCNA1↑, CDK2↓, APAF1↑, TumCCA↑, P53↑, BAX↑, VEGF↓, Bcl-2↓, Apoptosis↑, p‑Akt↓, p‑EGFR↓, p‑ERK↓, p‑STAT3↓, cardioP↑, Catalase↓, SOD↓, *BioAv↓, *antiOx↑, *ROS↓, *NO↓, *GSTs↑, *GSR↑, *SOD↑, *Catalase↑, *lipid-P↓, PI3K↓, Akt↓, CDK2↓, BNIP3↑, hTERT/TERT↓, DR5↑, Beclin-1/ATG6↑, TNF-α↓, NF-kB↓, IL1↓, IL6↓, EMT↓, FAK↓, E-cadherin↑, MDM2↓, NOTCH↓, MAPK↑, Vim↓, N-cadherin↓, Snail↓, MMP2↓, Twist↓, MMP9↓, ROS↑, MMP↓, *AChE↓, *MMP↑, *Aβ↓, *neuroP↑, Trx1↑, ROS↓, *NRF2↑, NRF2↓, *BBB↑, ChemoSen↑, GutMicro↑, *antiAll↑, *Mucositis↓, *TregCell↑, *Beclin-1/ATG6↓, *PI3K↑, *Akt↑, *mTOR↑,
8526- Matr,    A Systematic Review of the Pharmacology, Toxicology and Pharmacokinetics of Matrine
- Review, Nor, NA
*AntiCan↑, *Inflam↓, *antiOx↑, *AntiViral↑, *Bacteria↓, *antiAll↑, *Analgesic↑, *hepatoP↑, *cardioP↑, *neuroP↑, *toxicity↝, p38↓, IL6↓, JAK2↓, STAT3↓, Casp↑, PI3K↓, Akt↓, mTOR↓, Beclin-1/ATG6↑, PCNA↓, Bcl-2↓, XIAP↑, VEGF↓, NF-kB↓, MMP2↓, MMP9↓, P-gp/ABCB1↓, survivin↓, OCT4↓, SOX2↓, p62↓, *TNF-α↓, *IL6↓, *HMGB1↓, *AntiArt↑, *NF-kB↓, *IL6↓, *IL8↓, *IL1β↓, *IL17↓, *TNF-α↓, *ROS↓, *NRF2?, *AST↓, *ALAT↓, *TGF-β↓, *α-SMA↓, *JAK2↑, *STAT3↑, *BioAv↝, *Half-Life↝, ChemoSen↑, ATP↓, ROS↑,
8560- Matr,    Matrine: A Promising Natural Product With Various Pharmacological Activities
- Review, AD, NA - Review, Stroke, NA - Review, Var, NA
*antiAll↑, *Stroke↓, *AntiArt↑, TumCCA↑, VEGF↓, Apoptosis↑, P53↑, P21↑, PCNA↓, EIF4E↓, TumCP↓, TumCMig↓, IAP1↓, ROS↑, EMT↓, PAX2↓, ER Stress↑, HK2↓, Apoptosis↑, STAT3↓, mtDam↑, HMGB1↓, ChemoSen↑, p‑GSK‐3β↓, P-gp/ABCB1↓, MRP1/ABCC1↓, Vim↓, cycD1/CCND1↓, CDK4↓, GSH↓, SOD↓, mt-Cyt‑c↓, BAX↑, MMP9↓, MMP2↓, E-cadherin↓, N-cadherin↓, FOXO1↓, FOXO3↓, FOXO4↓, PI3K↓, ATF4↑, CHOP/DDIT3↑, *Aβ↓, *RAGE↓, *memory↑, *Learn↑, *cognitive↑, *MDA↓, *SOD↑, *GPx↑, *Catalase↑, *antiAll↑, *AHR↓, *SOCS-3↓, *ICAM-1↓, *ROS↓, cachexia↓, *BACE/β-secretase↓, *NF-kB↓, *TNF-α↓, *IL1β↓,
8553- Matr,    Research progress on the pharmacological effects of matrine
- Review, Nor, NA
*AntiCan↑, *antiAll↑, *Stroke↓, TumCI↓, TumCMig↓, TumCP↓, TumCCA↑, *AGEs↓, *Inflam↓, *antiOx↑, *neuroP↑, *Apoptosis↓, *IBI↑, *GutMicro↑, EGFR↓, *HSP60/HSPD1↓, *antiOx↑, *GSH↑, *Catalase↑, *AChE↓, *BChE↓, *neuroP↑, *PI3K↑, *Akt↑, *mTOR↑, *cognitive↑, *ROS↓, *toxicity↑,
3250- PBG,    Allergic Inflammation: Effect of Propolis and Its Flavonoids
- Review, Nor, NA
*SOD↑, *GPx↑, *Catalase↑, *Prx↑, *HO-1↑, *Inflam↓, *TNF-α↓, *IL1β↓, *IL4↑, *IL10↑, *TLR4↓, *LOX1↓, *COX1↓, *COX2/PTGS2↓, *NF-kB↓, *AP-1↓, *ROS↓, *GSH↑, *TGF-β↓, *IL8↓, *MMP9↓, *α-SMA↓, *MDA↓, *antiAll↑,
3587- PI,    Piperine: A review of its biological effects
- Review, Park, NA - Review, AD, NA
*hepatoP↑, *Inflam↓, *neuroP↑, *antiOx↑, *angioG↑, *cardioP↑, *BioAv↑, *P450↓, *Synergy↑, *BioEnh↑, E-cadherin↓, ER(estro)↓, MMP2↓, MMP9↓, VEGF↓, cMyc↓, BAX↑, P53↑, TumCG↓, OS↑, *cognitive↑, *GSK‐3β↓, *GSH↑, *Casp3↓, *Casp9↓, *Cyt‑c↓, *lipid-P↓, *motorD↑, *AChE↓, *memory↑, *cardioP↑, *ROS↓, *PPARγ↑, *ALAT↓, *AST↓, *ALP↓, *AMPK↑, *5HT↑, *SIRT1↑, *eff↑, *antiAll↑,
3597- PI,    Chronic diseases, inflammation, and spices: how are they linked?
- Review, AD, NA - Review, Park, NA - Review, Var, NA
*NF-kB↓, *MAPK↓, *AP-1↓, *COX2/PTGS2↓, *NOS2↓, *IL1β↓, *TNF-α↓, *PGE2↓, *STAT3↓, *IL10↑, *IL4↓, *IL5↓, P53↑, MMP9↓, MMP2↓, cMyc↓, VEGF↓, STAT3↓, survivin↓, p65↓, *antiAll↑,
3335- QC,    Recent advances on the improvement of quercetin bioavailability
- Review, Nor, NA
*BioAv↓, *antiOx↑, *antiAll↑, *AntiDiabetic↑,
873- QC,  RES,  CUR,  PI,    Combination Effects of Quercetin, Resveratrol and Curcumin on In Vitro Intestinal Absorption
- in-vitro, Nor, NA
*BioEnh↑, *antiAll↑, *Inflam↓, *Strength↓,
3014- RosA,    Rosmarinic Acid Supplementation Acts as an Effective Antioxidant for Restoring the Antioxidation/Oxidation Balance in Wistar Rats with Cadmium-Induced Toxicity
- in-vivo, Nor, NA
*antiOx↑, *Thiols↑, *GSH↑, *TAC↑, *SOD↑, *GPx↑, *Catalase↑, *ALP↓, *ALAT↓, *AST↓, *creat↓, *BUN↓, *H2O2↓, *MDA↓, *ROS↓, cardioP↑, hepatoP↑, neuroP↑, *antiAll↑,
7954- RT,    Rutin : therapeutic potential and recent advances in drug delivery
- Review, Nor, NA - Review, IBD, NA
*antiOx↑, *antiAll↑, *Inflam↓, *AntiTum↑, *Bacteria↓, *AntiViral↑, *BioAv↓, *AntiArt↑, *PLA2↓, *chemoP↑, *ROS↓, *Casp3↓, *TNF-α↓, *NF-kB↓, *cardioP↑, *Stroke↓, *TG/TAG↓, *FFA/NEFA↓, *LDL↓, *HDL↑, *AntiDiabetic↑, *MPO↓, *NF-kB↓, *BioAv↓, *BioAv↝,
7936- TQ,    Effect of Nigella sativa supplementation on lung function and inflammatory mediators in partly controlled asthma: a randomized controlled trial
- Trial, Asthma, NA
*Dose↝, *FEV1↑, *PEF↑, *IgE↓, *IFN-γ↑, *eff↑, *IL4∅, *IL10∅, *IL17∅, *antiAll↑,
7935- TQ,    Nigella sativa Supplementation Improves Asthma Control and Biomarkers: A Randomized, Double-Blind, Placebo-Controlled Trial
- Trial, Asthma, NA
*Dose↝, *eff↑, *Eos↓, *FEV1↑, *antiAll↑,
7937- TQ,    Effectiveness of thymoquinone in the treatment of experimental asthma
- in-vivo, Asthma, NA
*eff↑, *antiAll↑,
7938- TQ,    The effect of single dose of thymoquinone, the main constituents of Nigella sativa, in guinea pig model of asthma
- in-vivo, Asthma, NA
*Dose↝, *Eos↓, *IFN-γ↑, *Inflam↓, *IL4↓, *antiOx↑, *NO↓, *COX2/PTGS2↓, *5LO↓, *antiAll↑,
7939- TQ,    Effects of Nigella sativa and its constituents on inflammatory markers in ovalbumin-induced asthma model: a preclinical systematic review and meta-analysis
- Review, Asthma, NA
*IL4↓, *IL5↓, *IL13↓, *IL17↓, *IgE↓, *IFN-γ∅, *antiOx↑, *Inflam↓, *antiAll↑,
7940- TQ,    Anti-inflammatory effect of thymoquinone in a mouse model of allergic lung inflammation
- in-vivo, Asthma, NA
*Eos↓, *Th2↓, *IgE↓, *IgG1↓, *Inflam↓, *AirwayM↓, *IL4↓, *IL5↓, *IL13↓, *IFN-γ↑, *antiAll↑,
7941- TQ,    Downregulation of leukotriene biosynthesis by thymoquinone attenuates airway inflammation in a mouse model of allergic asthma
- in-vivo, Asthma, NA
*5LO↓, *LTB4↓, *LTC4↓, *Th2↓, *Eos↓, *Inflam↓, *antiAll↑,
7942- TQ,    Thymoquinone inhibits inflammation, neoangiogenesis and vascular remodeling in asthma mice
- in-vitro, Asthma, NA
*IL4↓, *IL5↓, *CD31/PECAM-1↓, *VEGFR2/KDR/Flk1↓, *PI3K↓, *Akt↓, *SLIT2↑, *Inflam↓, *VEGF↓, *antiAll↑,
6776- TQ,    Black cumin (Nigella sativa) and its constituent (thymoquinone): a review on antimicrobial effects
- Review, Nor, NA
*AntiBio↑, *AntiViral↑, *AntiFungal↑, *antiAll↑,
2124- TQ,    Thymoquinone: an emerging natural drug with a wide range of medical applications
- Review, Var, NA
hepatoP↑, Bax:Bcl2↑, cycD1/CCND1↓, P21↑, TRAIL↑, P53↑, TumCCA↑, hepatoP↑, *ALAT↓, *AST↓, *MDA↓, *GSSG↓, *COX2/PTGS2↓, *lipid-P↓, PPARγ↑, p38↑, ROS↑, ChemoSen↑, selectivity↑, selectivity↑, *MDA↓, *SOD↑, *antiAll↑,
2085- TQ,    Anticancer Activities of Nigella Sativa (Black Cumin)
- Review, Var, NA
MMP↓, Casp3↑, Casp8↑, Casp9↓, cl‑PARP↑, Cyt‑c↑, Bax:Bcl2↑, NF-kB↓, IAP1↓, IAP2/BIRC3↓, XIAP↓, Bcl-xL↓, survivin↓, cJun↑, p38↑, Akt↑, chemoP↑, *radioP↑, *antiAll↑,
3410- TQ,    Anti-inflammatory effects of thymoquinone and its protective effects against several diseases
- Review, Arthritis, NA
*Inflam↓, *antiOx↑, *COX2/PTGS2↓, *NRF2↑, *HO-1↑, *IL1β↓, *IL6↓, *TNF-α↓, *IFN-γ↓, *PGE2↓, *cardioP↑, *Catalase↑, *SOD↑, *Thiols↑, *neuroP↑, *IL12↓, *MCP1/CCL2↓, *CXCc↓, *ROS↓, *antiAll↑,
3404- TQ,    The Neuroprotective Effects of Thymoquinone: A Review
- Review, Var, NA - Review, AD, NA - Review, Park, NA - Review, Stroke, NA
*Inflam↓, AntiCan↑, *TNF-α↓, *IL6↓, *IL1β↓, *NF-kB↓, *iNOS↓, *NRF2↑, *neuroP↑, *MMP↑, *ROS↓, *MDA↓, *GSH↑, *Catalase↑, *SOD↑, *IL12↓, *MCP1/CCL2↓, *IP-10/CXCL-10↓, *PGE2↓, *antiAll?,
3573- TQ,    Chronic diseases, inflammation, and spices: how are they linked?
- Review, Var, NA
NF-kB↓, XIAP↓, PI3K↓, Akt↓, STAT3↓, JAK2↓, cSrc↓, PCNA↓, MMP2↓, ERK↓, Ki-67↓, Bcl-2↓, VEGF↓, p65↓, COX2/PTGS2↓, MMP9↓, *antiAll↑, *Eos↓, *CD31/PECAM-1↓, *α-SMA↓,
7943- VitD3,    Vitamin D for the management of asthma
- Review, Asthma, NA
*eff∅, *antiAll∅,

Showing Research Papers: 51 to 79 of 79
Prev Page 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 79

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

Catalase↓, 2,   GSH↓, 1,   lipid-P?, 1,   NRF2↓, 1,   ROS↓, 4,   ROS↑, 17,   SOD↓, 2,   Trx1↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Tf↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC2↓, 1,   CDC25↓, 2,   compIV↓, 1,   MFN2↑, 1,   mtDam↑, 2,   PGC-1α↑, 1,   SDH↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACC↑, 1,   p‑ACC↑, 1,   AMPK↓, 1,   AMPK↑, 3,   ATP↓, 2,   Glycolysis↓, 2,   GSK‐3β↓, 1,   GSK‐3β↑, 1,   p‑GSK‐3β↓, 1,   HK2↓, 2,   lipidLev↓, 1,   SCD1↓, 1,   SREBP2↓, 1,  

Cell Death(tgid=5) ⓘ

AIF↑, 2,   APAF1↑, 1,   Apoptosis↑, 15,   Bak↑, 2,   BAX↑, 10,   Bax:Bcl2↑, 3,   Bcl-2↓, 9,   Bcl-xL↓, 3,   BNIP3↑, 1,   Casp↑, 2,   Casp↝, 1,   Casp3↑, 14,   cl‑Casp3↑, 3,   cl‑Casp3⇅, 1,   Casp8↑, 7,   Casp9↓, 1,   Casp9↑, 9,   cl‑Casp9↑, 1,   proCasp9↓, 1,   cFLIP↓, 1,   Cyt‑c↑, 9,   mt-Cyt‑c↓, 1,   Diablo↑, 1,   DR5↑, 4,   FasL↑, 1,   GranB/GZMB↓, 1,   GSDMD↑, 1,   IAP1↓, 3,   IAP2/BIRC3↓, 2,   ICAD↓, 1,   iNOS↓, 1,   Mcl-1↓, 2,   MDM2↓, 1,   Necroptosis↑, 1,   p38↓, 1,   p38↑, 6,   survivin↓, 7,   TRAIL↑, 1,   TumCD↑, 2,   XIAP↓, 6,   XIAP↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 14,   Akt↑, 1,   p‑Akt↓, 5,   cSrc↓, 1,   EGFR↓, 3,   p‑EGFR↓, 1,   ERK↓, 3,   ERK↑, 2,   p‑ERK↓, 3,   HER2/EBBR2↓, 2,   IKKα↓, 1,   JAK2↓, 2,   JNK↓, 1,   JNK↑, 2,   LIMK1↓, 1,   MAPK↓, 2,   MAPK↑, 2,   MAPK↝, 1,   mTOR↓, 5,   mTOR↝, 1,   P70S6K↓, 1,   p‑PDGFR-BB↓, 1,   PI3K↓, 11,   PI3K↑, 1,   PKCδ↓, 2,   PTEN↑, 1,   RIP1↓, 1,   Sp1/3/4↓, 1,   STAT3↓, 11,   STAT3↑, 1,   p‑STAT3↓, 2,   STK11/LKB1↑, 1,   p‑STK11/LKB1↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF4↑, 1,   cJun↑, 1,   cMyc↓, 4,   EZH2↓, 1,   FOXM1↓, 2,   FOXO1↓, 1,   FOXO3↓, 1,   FOXO4↓, 1,   HDAC8↓, 1,   miR-124-3p↓, 1,   miR-200b↑, 1,   miR-34a↓, 1,   OCT4↓, 1,   PAX2↓, 1,   SOX2↓, 1,   SOX9↓, 1,   tumCV↓, 5,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 3,   eIF2α↑, 1,   ER Stress↑, 4,   GRP78/BiP↑, 1,   HSP90↓, 1,   PERK↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 2,   CTSB↓, 1,   CTSD↓, 1,   LC3II↑, 1,   lysoMP↑, 1,   p62↓, 1,   TumAuto↑, 2,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 4,   hTERT/TERT↓, 1,   P53↓, 1,   P53↑, 7,   P53↝, 1,   p‑P53↓, 1,   PARP↑, 1,   cl‑PARP↑, 12,   PCNA↓, 3,   TOP1↓, 1,   TOP2↓, 1,   TOP2↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 2,   p‑CDK1↓, 1,   CDK2↓, 3,   CDK4↓, 5,   CDK6↓, 1,   CDK6↑, 1,   cycA1/CCNA1↑, 1,   CycB/CCNB1↓, 2,   cycD1/CCND1↓, 8,   cycD1/CCND1↑, 1,   cycE/CCNE↓, 1,   GADD45A↑, 1,   Ki-67↓, 1,   mitA↑, 1,   P21↓, 1,   P21↑, 6,   p27/CDKN1B↓, 2,   p‑RB1↓, 2,   TumCCA↑, 17,   WEE1↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

p‑4E-BP1↓, 1,   ALDH↓, 1,   CSCs↓, 2,   EIF4E↓, 1,   Ki-67↓, 1,   Let-7↑, 1,   NOTCH↓, 2,   STAT1↓, 1,   TumCG↓, 2,   TumCG↑, 1,   TumCP↓, 9,   Wnt↓, 4,  

Migration(tgid=13) ⓘ

AntiAg?, 1,   BACH1↓, 1,   Ca+2↑, 1,   i-Ca+2↑, 1,   cal2↓, 1,   E-cadherin↓, 4,   E-cadherin↑, 1,   EMT↓, 5,   FAK↓, 2,   LAMs↓, 1,   MALAT1↓, 1,   MET↓, 1,   MMP1↓, 2,   MMP2↓, 11,   MMP9↓, 12,   MMPs↓, 1,   N-cadherin↓, 3,   PDGF↓, 1,   Slug?, 1,   Snail?, 1,   Snail↓, 1,   TGF-β↓, 1,   TIMP2↓, 1,   TumCI↓, 6,   TumCMig↓, 7,   TumMeta↓, 1,   TumMeta↑, 1,   Twist↓, 1,   Vim↓, 2,   β-catenin/ZEB1↓, 4,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 5,   Hif1a↓, 3,   VEGF↓, 14,   VEGFR2/KDR/Flk1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

GLUT1↓, 1,   MMP↓, 6,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD25+↑, 1,   CD4+↑, 1,   CD47↓, 1,   CD8+↑, 2,   COX2/PTGS2↓, 8,   CXCR4↓, 2,   DR4↑, 1,   FOXP3↑, 2,   HMGB1↓, 1,   IFN-γ↑, 1,   IL1↓, 1,   IL12↑, 1,   IL1α↓, 1,   IL1β↓, 1,   IL6↓, 5,   Imm↝, 1,   Inflam↓, 2,   LTA/TNF-β↑, 1,   MCP1/CCL2↓, 1,   MIP‑1α/CCL3↓, 1,   MIP2↓, 1,   NF-kB↓, 11,   p‑NF-kB↓, 1,   NK cell↑, 1,   NLRP3↑, 2,   p65↓, 2,   ac‑p65↓, 1,   PD-1↓, 1,   PD-L1↓, 2,   PGE2↓, 2,   PSA↓, 2,   T-Cell↑, 1,   TNF-α↓, 5,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 5,   ER(estro)↓, 1,   PPARα↓, 1,   PPARγ↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 1,   BioAv↓, 2,   BioAv↑, 3,   BioAv↝, 1,   ChemoSen↑, 14,   CYP1A1↓, 1,   Dose↑, 2,   Dose↝, 5,   eff↓, 1,   eff↑, 3,   eff↝, 1,   Half-Life↓, 1,   MRP1/ABCC1↓, 1,   P-gp/ABCB1↓, 3,   P450↓, 1,   selectivity↑, 6,   Synergy↑, 10,  

Clinical Biomarkers(tgid=22) ⓘ

AR↓, 5,   ascitic↓, 1,   EGFR↓, 3,   p‑EGFR↓, 1,   EZH2↓, 1,   FOXM1↓, 2,   HER2/EBBR2↓, 2,   hTERT/TERT↓, 1,   IL6↓, 5,   PD-L1↓, 2,   PSA↓, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 5,   cachexia↓, 1,   cardioP↑, 2,   chemoP↑, 4,   chemoPv↑, 1,   hepatoP↑, 3,   neuroP↑, 1,   NP/CIPN↓, 2,   OS↑, 1,   Pain↓, 1,   PFS↑, 1,   QoL↑, 2,   radioP↑, 3,   Risk↑, 1,   toxicity↓, 1,   TumVol↓, 2,   TumW↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

GutMicro↑, 2,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 2,  
Total Targets: 300

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 33,   Catalase↑, 18,   Fenton↓, 1,   GPx↑, 11,   GSH↑, 11,   GSR↑, 1,   GSSG↓, 1,   GSTs↓, 1,   GSTs↑, 4,   H2O2↓, 2,   HDL↑, 3,   HO-1↓, 1,   HO-1↑, 10,   hyperG↓, 1,   Keap1↝, 1,   lipid-P↓, 8,   MDA↓, 19,   MPO↓, 5,   MPO↑, 1,   NOX↓, 1,   NOX4↓, 1,   NQO1↑, 2,   NRF2?, 1,   NRF2↑, 18,   Prx↑, 1,   RNS↓, 2,   ROS↓, 34,   ROS↑, 1,   ROS⇅, 1,   mt-ROS?, 1,   SOD↑, 22,   TAC↑, 3,   TBARS↓, 3,   Thiols↑, 2,   VitE↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compII↑, 1,   compIII↑, 1,   HSP60/HSPD1↓, 1,   Insulin↑, 1,   OXPHOS↑, 1,   PGC-1α↑, 1,   PGC-1α↝, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 6,   ALAT↓, 11,   AMPK↑, 2,   ATP↑, 4,   DGAT1↓, 1,   FASN↓, 1,   FFA/NEFA↓, 1,   glucose↓, 1,   glucose↝, 1,   Glycolysis↓, 1,   GSK‐3β↓, 3,   HK2↓, 1,   lactateProd↓, 1,   LDL↓, 4,   LTB4↓, 1,   LTC4↓, 2,   NADPH↓, 3,   NADPH↑, 1,   PFK↓, 1,   PLA2↓, 2,   SIRT1↑, 1,  

Cell Death(tgid=5) ⓘ

AIF↓, 1,   Apoptosis↓, 3,   ASK1↓, 1,   BAX↓, 2,   Bcl-2↓, 1,   Bcl-2↑, 1,   Bcl-xL↑, 1,   Casp12↓, 1,   Casp3↓, 7,   Casp9↓, 3,   Cyt‑c↓, 2,   GranB/GZMB↓, 1,   iNOS↓, 4,   p38↓, 2,   p‑p38↓, 1,   survivin↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 1,   Akt↑, 6,   ERK↓, 1,   JAK2↑, 2,   p‑JNK↓, 2,   MAPK↓, 1,   MAPK↑, 1,   mTOR↓, 1,   mTOR↑, 3,   PI3K↓, 2,   PI3K↑, 6,   PKCδ↑, 1,   STAT3↓, 1,   STAT3↑, 2,   STAT6↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 1,   ATF4↓, 1,   HDAC↓, 1,   other↑, 2,   other↝, 5,   RUNX2↑, 1,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,   p‑eIF2α↓, 1,   ER Stress↓, 2,   GRP78/BiP↓, 2,   HSP90↓, 1,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 2,   Beclin-1/ATG6↑, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3II↑, 1,   p62↑, 2,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 2,   PARP1↓, 1,   γH2AX↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMP2↑, 1,   neuroG↑, 1,   TumCP↓, 2,  

Migration(tgid=13) ⓘ

AntiAg↑, 5,   AP-1↓, 3,   Ca+2↑, 1,   Ca+2↝, 1,   COL1↑, 1,   COL3A1↓, 1,   E-cadherin↑, 1,   MMP13↓, 1,   MMP3↓, 2,   MMP9↓, 2,   SLIT2↑, 1,   p‑T-cadherin↓, 1,   TGF-β↓, 2,   TGF-β↑, 1,   TGF-β1↑, 1,   TregCell↑, 1,   TumCI↓, 1,   TumCMig↓, 1,   α-SMA↓, 3,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↑, 1,   CD31/PECAM-1↓, 2,   E-sel↓, 1,   Hif1a↓, 2,   LOX1↓, 1,   NO↓, 7,   NO↑, 1,   TXA2↓, 1,   VCAM-1↓, 1,   VEGF↓, 2,   VEGFR2/KDR/Flk1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 3,   GastroP↑, 2,   IBI↑, 2,   MMP↑, 5,   MUC5AC↓, 2,   TRPA1↑, 1,   TRPV3↑, 1,   VGSC↓, 1,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

BALF-Infl↓, 3,   BALF-Lym↓, 1,   CCL11↓, 2,   CD25+↑, 1,   CD4+↑, 2,   CD40↓, 1,   COX1↓, 3,   COX2/PTGS2↓, 16,   COX2/PTGS2↑, 1,   CXCc↓, 1,   CXCL15↓, 1,   CXCR4↓, 1,   Eos↓, 8,   p‑FcεRI↓, 1,   FOXP3↑, 1,   GM-CSF↓, 1,   HMGB1↓, 3,   ICAM-1↓, 1,   IFN-γ↓, 2,   IFN-γ↑, 3,   IFN-γ∅, 1,   IgE↓, 7,   IgG1↓, 1,   IL10↓, 2,   IL10↑, 5,   IL10∅, 1,   IL12↓, 2,   IL13↓, 7,   IL17↓, 3,   IL17∅, 1,   IL18↓, 1,   IL1RL1/ST2↓, 1,   IL1β↓, 16,   IL33↓, 1,   IL4↓, 13,   IL4↑, 2,   IL4∅, 1,   IL5↓, 9,   IL6↓, 15,   IL8↓, 4,   ILC2↓, 1,   Imm↑, 2,   Inflam↓, 47,   Inflam↑, 1,   IP-10/CXCL-10↓, 2,   LPS↓, 1,   M2 MC↑, 1,   pol-M2 MC↑, 1,   MCP1/CCL2↓, 5,   MIP‑1α/CCL3↓, 1,   Neut↓, 1,   NF-kB↓, 21,   NF-kB↑, 1,   NLRP3↓, 4,   PGD2↓, 1,   PGE2↓, 10,   PGE2↑, 1,   RAGE↓, 1,   RANTES↓, 1,   SOCS-3↓, 1,   Th1 response↓, 1,   Th2↓, 3,   Th2↑, 2,   TLR4↓, 2,   TNF-α↓, 27,   Treg lymp↝, 1,   β-HEX↓, 2,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 2,   AChE↓, 7,   BChE↓, 2,   BDNF↑, 1,   ChAT↑, 1,   MAOA↓, 1,   NGF↑, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 2,   APP↓, 1,   Aβ↓, 5,   Aβ42↓, 1,   BACE/β-secretase↓, 4,   tau↓, 2,   p‑tau↓, 1,   XO↓, 2,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AHR↓, 1,   PPARγ↓, 1,   PPARγ↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 6,   BioAv↑, 9,   BioAv↝, 8,   BioEnh↑, 2,   CompStab↝, 1,   CYP2E1↓, 1,   Dose?, 1,   Dose↓, 1,   Dose↑, 1,   Dose↝, 19,   eff↑, 13,   eff↝, 2,   eff∅, 1,   Half-Life↑, 1,   Half-Life↝, 3,   P450↓, 1,   selectivity↑, 1,   Synergy↑, 5,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 11,   ALP↓, 2,   AST↓, 11,   BloodF↑, 1,   BP↓, 1,   BUN↓, 1,   creat↓, 2,   CRP↓, 2,   FEV1↑, 2,   IL6↓, 15,   LDH↑, 1,   NLR↓, 1,   NOS2↓, 1,   PEF↑, 1,   RAGE↓, 1,   SpO2↑, 1,   TG/TAG↓, 1,   Urea↓, 1,  

Functional Outcomes(tgid=23) ⓘ

Airway↓, 3,   AirwayM↓, 4,   Analgesic↑, 1,   antiAll?, 1,   antiAll↑, 79,   antiAll∅, 1,   AntiArt↑, 6,   AntiCan↑, 10,   AntiDiabetic↑, 11,   antiPs↑, 2,   AntiTum↑, 2,   cardioP↑, 17,   chemoP↑, 4,   chemoPv↑, 2,   cognitive↑, 9,   cough?, 1,   diuretic↑, 1,   hepatoP↑, 19,   Learn↑, 1,   memory↑, 7,   motorD↑, 2,   Mucositis↓, 2,   neuroP↑, 21,   Obesity↓, 8,   OS↑, 1,   Pain↓, 2,   QoL↓, 1,   radioP↑, 1,   RenoP↑, 2,   SoreThr?, 1,   Strength↓, 1,   Stress↓, 3,   Stroke↓, 7,   toxicity↓, 13,   toxicity↑, 1,   toxicity↝, 4,   Weight↑, 1,   Wound Healing↓, 1,   Wound Healing↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 12,   AntiFungal↑, 3,   AntiP↑, 1,   AntiViral↑, 6,   Bacteria↓, 7,   Diar↓, 1,   GutMicro↑, 5,   Inf↓, 1,   Sepsis↓, 4,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 3,  
Total Targets: 329

Scientific Paper Hit Count for: antiAll, antiallergic/antiasmatic
15 Hydrogen Gas
14 Thymoquinone
4 Boswellia (frankincense)
4 lambertianic acid
3 Emodin
3 Luteolin
3 Matrine
3 Piperine
2 1,8-Cineole
2 α-Bisabolol / Chamomile oil
2 isoquercitrin
2 Licochalcone A
2 Quercetin
1 Allicin (mainly Garlic)
1 DTS(dibenzyl trisulphide) from Anamu
1 Artemisinin
1 Astaxanthin
1 Baicalein
1 Benzyl isothiocyanate
1 Phenethyl isothiocyanate
1 Allyl isothiocyanate
1 Carvacrol
1 Camu camu
1 Chocolate
1 Chrysin
1 Eugenol
1 Formononetin
1 Geraniol
1 Grapeseed extract
1 Honokiol
1 Magnolol
1 Kaempferol
1 Licorice
1 Propolis -bee glue
1 Resveratrol
1 Curcumin
1 Rosmarinic acid
1 Rutin
1 Vitamin D3
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1745  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

Home Page