Mcl-1 Cancer Research Results

Mcl-1, myeloid cell leukemia 1: Click to Expand ⟱
Source: HalifaxProj(inhibit)
Type:
A member of the Bcl-2 family of proteins, which play a crucial role in regulating apoptosis, or programmed cell death. In cancer, Mcl-1 is often overexpressed, contributing to the development and progression of various types of tumors.
Mcl-1 is often overexpressed in several cancers, including hematological malignancies (like leukemia and lymphoma) and solid tumors (such as breast, lung, and prostate cancers).
Mcl-1 inhibits apoptosis by binding to pro-apoptotic proteins, preventing them from triggering the cell death pathway.


Scientific Papers found: Click to Expand⟱
930- MushShi,    Active Hexose Correlated Compound (AHCC) Inhibits the Proliferation of Ovarian Cancer Cells by Suppressing Signal Transducer and Activator of Transcription 3 (STAT3) Activation
- in-vitro, Ovarian, NA
p‑STAT3↓, PTPN6↑, cycD1/CCND1↓, Bcl-2↓, Mcl-1↓, survivin↓, VEGF↓,
1807- NarG,    A Systematic Review of the Preventive and Therapeutic Effects of Naringin Against Human Malignancies
- Review, NA, NA
AntiTum↑, TumCP↓, tumCV↓, TumCCA↑, Mcl-1↓, RAS↓, e-Raf↓, VEGF↓, AntiAg↑, MMP2↓, MMP9↓, TIMP2↑, TIMP1↑, p38↓, Wnt↓, β-catenin/ZEB1↑, Casp↑, P53↑, BAX↑, COX2↓, GLO-I↓, CYP1A1↑, lipid-P↓, p‑Akt↓, p‑mTOR↓, VCAM-1↓, P-gp↓, survivin↓, Bcl-2↓, ROS↑, ROS↑, MAPK↑, STAT3↓, chemoP↑,
4627- OLE,    Oleuropein regulates ubiquitination-mediated Mcl-1 turnover and exhibits antitumor activity
- in-vitro, Oral, NA
tumCV↓, Mcl-1↓, TumCG↓, toxicity∅, RadioS↑, AntiTum↑,
4953- PEITC,    PEITC: a natural compound effective in killing primary leukemia cells and overcoming drug resistance
- in-vitro, CLL, NA
ROS↑, GSH↓, TumCD↓, eff↓, Mcl-1↓, Casp3↑,
4918- PEITC,    Nutritional Sources and Anticancer Potential of Phenethyl Isothiocyanate: Molecular Mechanisms and Therapeutic Insights
- Review, Var, NA
Apoptosis↑, TumCP↓, angioG↓, TumMeta↓, NF-kB↓, Akt↓, MAPK↓, *BioAv↓, ROS↑, lipid-P↑, AIF↑, Cyt‑c↑, DR4↑, DR5↑, TumCCA↑, JAK↓, STAT3↓, MMP2↓, MMP9↓, PKCδ↓, Hif1a↓, JNK↓, Mcl-1↓, COX2↓, MMP↓, Casp3↑, ChemoSen↑, *BioAv↓, Half-Life↓,
5184- PEITC,    Phenethyl isothiocyanate exhibits antileukemic activity in vitro and in vivo by inactivation of Akt and activation of JNK pathways
- vitro+vivo, AML, U937
Casp3↑, Casp9↑, Casp8↑, cl‑PARP↑, Apoptosis↑, Mcl-1↓, Akt↓, JNK↑, eff↑,
2950- PL,    Overview of piperlongumine analogues and their therapeutic potential
- Review, Var, NA
AntiAg↑, neuroP↑, Inflam↓, NO↓, PGE2↓, MMP3↓, MMP13↓, TumCMig↓, TumCI↓, p38↑, JNK↑, NF-kB↑, ROS↑, FOXM1↓, TrxR1↓, GSH↓, Trx↓, cMyc↓, Casp3↑, Bcl-2↓, Mcl-1↓, STAT3↓, AR↓, DNAdam↑,
3378- QC,    CK2 and PI3K are direct molecular targets of quercetin in chronic lymphocytic leukaemia
- in-vitro, AML, NA
CK2↓, PI3K↓, TumCD↑, Akt↓, Mcl-1↓, PTEN↑,
50- QC,    Anticancer effect and mechanism of polymer micelle-encapsulated quercetin on ovarian cancer
- vitro+vivo, Ovarian, A2780S
Casp3↑, Casp9↑, Mcl-1↓, Bcl-2↓, BAX↑, angioG↓, TumCG↓, Apoptosis↑, p‑p44↓, Akt↓, TumCP↓, eff↑,
76- QC,    Multifaceted preventive effects of single agent quercetin on a human prostate adenocarcinoma cell line (PC-3): implications for nutritional transcriptomics and multi-target therapy
- in-vitro, Pca, PC3
aSmase↝, Diablo↑, Fas↓, Hsc70↓, Hif1a↓, Mcl-1↓, HSP90↓, FLT4↓, EphB4↓, DNA-PK↓, PARP1↓, ATM↓, XIAP↝, PLC↓, GnT-V↝, heparanase↝, NM23↑, CSR1↑, SPP1↓, DNMT1↓, HDAC4↓, CXCR4↓, β-catenin/ZEB1↓, FBXW7↝, AMACR↓, cycD1/CCND1↓, IGF-1R↓, IMPDH1↓, IMPDH2↓, HEC1↓, NHE1↓, NOS2↓,
881- RES,    Resveratrol inhibits Src and Stat3 signaling and induces the apoptosis of malignant cells containing activated Stat3 protein
- in-vitro, BC, MDA-MB-231 - in-vitro, PC, PANC1 - in-vitro, Pca, DU145
TumCCA↑, cycD1/CCND1↓, Bcl-xL↓, Mcl-1↓, other↓,
2982- RES,    The flavonoid resveratrol suppresses growth of human malignant pleural mesothelioma cells through direct inhibition of specificity protein 1
- in-vitro, Melanoma, MSTO-211H
tumCV↓, Apoptosis↑, Sp1/3/4↓, p27↓, P21↓, cycD1/CCND1↓, Mcl-1↓, survivin↓,
1469- SFN,    Sulforaphane enhances the therapeutic potential of TRAIL in prostate cancer orthotopic model through regulation of apoptosis, metastasis, and angiogenesis
- in-vitro, Pca, PC3 - in-vitro, Pca, LNCaP - in-vivo, Pca, NA
eff↑, ROS↑, MMP↓, Casp3↑, Casp9↑, DR4↑, DR5↑, BAX↑, Bak↑, BIM↑, NOXA↑, Bcl-2↓, Bcl-xL↓, Mcl-1↓, eff↓, TumCG↓, TumCP↓, eff↑, NF-kB↓, PI3K↓, Akt↓, MEK↓, ERK↓, angioG↓, FOXO3↑,
3301- SIL,    Critical review of therapeutic potential of silymarin in cancer: A bioactive polyphenolic flavonoid
- Review, Var, NA
Inflam↓, TumCCA↑, Apoptosis↓, TumMeta↓, TumCG↓, angioG↓, chemoP↑, radioP↑, p‑ERK↓, p‑p38↓, p‑JNK↓, P53↑, Bcl-2↓, Bcl-xL↓, TGF-β↓, MMP2↓, MMP9↓, E-cadherin↑, Wnt↓, Vim↓, VEGF↓, IL6↓, STAT3↓, *ROS↓, IL1β↓, PGE2↓, CDK1↓, CycB/CCNB1↓, survivin↓, Mcl-1↓, Casp3↑, Casp9↑, cMyc↓, COX2↓, Hif1a↓, CXCR4↓, CSCs↓, EMT↓, N-cadherin↓, PCNA↓, cycD1/CCND1↓, ROS↑, eff↑, eff↑, eff↑, HER2/EBBR2↓,
3293- SIL,    Silymarin (milk thistle extract) as a therapeutic agent in gastrointestinal cancer
- Review, Var, NA
hepatoP↑, TumMeta↓, Inflam↓, chemoP↑, radioP↑, Half-Life↝, *GSTs↑, p‑JNK↑, BAX↑, p‑p38↑, cl‑PARP↑, Bcl-2↓, p‑ERK↓, TumVol↓, eff↑, TumCCA↑, STAT3↓, Mcl-1↓, survivin↓, Bcl-xL↓, Casp3↑, Casp9↑, eff↑, CXCR4↓, Dose↝,
3289- SIL,    Silymarin: a promising modulator of apoptosis and survival signaling in cancer
- Review, Var, NA
*BioAv↝, *BioAv↓, Fas↑, FasL↑, FADD↑, pro‑Casp8↑, Apoptosis↑, DR5↑, Bcl-2↑, BAX↑, Casp3↑, PI3K↓, FOXM1↓, p‑mTOR↓, p‑P70S6K↓, Hif1a↓, Akt↑, angioG↓, STAT3↓, NF-kB↓, lipid-P↓, eff↑, CDK1↓, survivin↓, CycB/CCNB1↓, Mcl-1↓, Casp9↑, AP-1↓, BioAv↑,
3043- SK,    Shikonin Induces Apoptosis by Inhibiting Phosphorylation of IGF-1 Receptor in Myeloma Cells.
- in-vitro, Melanoma, RPMI-8226
IGF-1↓, Apoptosis↑, TumCCA↑, MMP↓, Casp3↑, P53↑, BAX↑, Mcl-1↓, EGFR↓, Src↑, KDR/FLK-1↓, p‑IGF-1↓, PI3K↓, Akt↓,
5332- TFdiG,    Theaflavin-3,3′-digallate triggers apoptosis in osteosarcoma cells via the caspase pathway
- vitro+vivo, OS, 143B - in-vitro, OS, U2OS
tumCV↓, cl‑Casp3↑, cl‑Casp9↑, p‑γH2AX↑, BAX↑, Bak↑, Cyt‑c↑, Mcl-1↓, survivin↓, TumVol↓, Wnt↓, β-catenin/ZEB1↓, Dose↝, ROS↑, eff↓, TumW↓, Ki-67↓,
3427- TQ,    Chemopreventive and Anticancer Effects of Thymoquinone: Cellular and Molecular Targets
ROS⇅, Fas↑, DR5↑, TRAIL↑, Casp3↑, Casp8↑, Casp9↑, P53↑, mTOR↓, Bcl-2↓, BID↓, CXCR4↓, JNK↑, p38↑, MAPK↑, LC3II↑, ATG7↑, Beclin-1↑, AMPK↑, PPARγ↑, eIF2α↓, P70S6K↓, VEGF↓, ERK↓, NF-kB↓, XIAP↓, survivin↓, p65↓, DLC1↑, FOXO↑, TET2↑, CYP1B1↑, UHRF1↓, DNMT1↓, HDAC1↓, IL2↑, IL1↓, IL6↓, IL10↓, IL12↓, TNF-α↓, iNOS↓, COX2↓, 5LO↓, AP-1↓, PI3K↓, Akt↓, cMET↓, VEGFR2↓, CXCL1↓, ITGA5↓, Wnt↓, β-catenin/ZEB1↓, GSK‐3β↓, Myc↓, cycD1/CCND1↓, N-cadherin↓, Snail↓, Slug↓, Vim↓, Twist↓, Zeb1↓, MMP2↓, MMP7↓, MMP9↓, JAK2↓, STAT3↓, NOTCH↓, cycA1/CCNA1↓, CDK2↓, CDK4↓, CDK6↓, CDC2↓, CDC25↓, Mcl-1↓, E2Fs↓, p16↑, p27↑, P21↑, ChemoSen↑,
2084- TQ,    Thymoquinone, as an anticancer molecule: from basic research to clinical investigation
- Review, Var, NA
*ROS↓, *chemoPv↑, ROS↑, ROS⇅, MUC4↓, selectivity↑, AR↓, cycD1/CCND1↓, Bcl-2↓, Bcl-xL↓, survivin↓, Mcl-1↓, VEGF↓, cl‑PARP↑, ROS↑, HSP70/HSPA5↑, P53↑, miR-34a↑, Rac1↓, TumCCA↑, NOTCH↓, NF-kB↓, IκB↓, p‑p65↓, IAP1↓, IAP2↑, XIAP↓, TNF-α↓, COX2↓, Inflam↓, α-tubulin↓, Twist↓, EMT↓, mTOR↓, PI3K↓, Akt↓, BioAv↓, ChemoSen↑, BioAv↑, PTEN↑, chemoPv↑, RadioS↑, *Half-Life↝, *BioAv↝,

Showing Research Papers: 51 to 70 of 70
Prev Page 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 70

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

CYP1A1↑, 1,   GSH↓, 2,   lipid-P↓, 2,   lipid-P↑, 1,   ROS↑, 10,   ROS⇅, 2,   Trx↓, 1,   TrxR1↓, 1,  

Mitochondria & Bioenergetics ⓘ

AIF↑, 1,   CDC2↓, 1,   CDC25↓, 1,   MEK↓, 1,   MMP↓, 3,   e-Raf↓, 1,   XIAP↓, 2,   XIAP↝, 1,  

Core Metabolism/Glycolysis ⓘ

AMACR↓, 1,   AMPK↑, 1,   ATG7↑, 1,   cMyc↓, 2,   GLO-I↓, 1,   PPARγ↑, 1,  

Cell Death ⓘ

Akt↓, 8,   Akt↑, 1,   p‑Akt↓, 1,   Apoptosis↓, 1,   Apoptosis↑, 6,   aSmase↝, 1,   Bak↑, 2,   BAX↑, 7,   Bcl-2↓, 9,   Bcl-2↑, 1,   Bcl-xL↓, 5,   BID↓, 1,   BIM↑, 1,   Casp↑, 1,   Casp3↑, 11,   cl‑Casp3↑, 1,   Casp8↑, 2,   pro‑Casp8↑, 1,   Casp9↑, 7,   cl‑Casp9↑, 1,   CK2↓, 1,   CSR1↑, 1,   Cyt‑c↑, 2,   Diablo↑, 1,   DR4↑, 2,   DR5↑, 4,   FADD↑, 1,   Fas↓, 1,   Fas↑, 2,   FasL↑, 1,   IAP1↓, 1,   IAP2↑, 1,   iNOS↓, 1,   JNK↓, 1,   JNK↑, 3,   p‑JNK↓, 1,   p‑JNK↑, 1,   MAPK↓, 1,   MAPK↑, 2,   Mcl-1↓, 20,   Myc↓, 1,   NOXA↑, 1,   p27↓, 1,   p27↑, 1,   p38↓, 1,   p38↑, 2,   p‑p38↓, 1,   p‑p38↑, 1,   survivin↓, 9,   TRAIL↑, 1,   TumCD↓, 1,   TumCD↑, 1,  

Kinase & Signal Transduction ⓘ

HER2/EBBR2↓, 1,   Sp1/3/4↓, 1,  

Transcription & Epigenetics ⓘ

other↓, 1,   SPP1↓, 1,   tumCV↓, 4,  

Protein Folding & ER Stress ⓘ

eIF2α↓, 1,   Hsc70↓, 1,   HSP70/HSPA5↑, 1,   HSP90↓, 1,  

Autophagy & Lysosomes ⓘ

Beclin-1↑, 1,   LC3II↑, 1,  

DNA Damage & Repair ⓘ

ATM↓, 1,   CYP1B1↑, 1,   DNA-PK↓, 1,   DNAdam↑, 1,   DNMT1↓, 2,   p16↑, 1,   P53↑, 5,   cl‑PARP↑, 3,   PARP1↓, 1,   PCNA↓, 1,   UHRF1↓, 1,   p‑γH2AX↑, 1,  

Cell Cycle & Senescence ⓘ

CDK1↓, 2,   CDK2↓, 1,   CDK4↓, 1,   cycA1/CCNA1↓, 1,   CycB/CCNB1↓, 2,   cycD1/CCND1↓, 7,   E2Fs↓, 1,   P21↓, 1,   P21↑, 1,   TumCCA↑, 7,  

Proliferation, Differentiation & Cell State ⓘ

cMET↓, 1,   CSCs↓, 1,   EMT↓, 2,   ERK↓, 2,   p‑ERK↓, 2,   FBXW7↝, 1,   FOXM1↓, 2,   FOXO↑, 1,   FOXO3↑, 1,   GSK‐3β↓, 1,   HDAC1↓, 1,   HDAC4↓, 1,   IGF-1↓, 1,   p‑IGF-1↓, 1,   IGF-1R↓, 1,   miR-34a↑, 1,   mTOR↓, 2,   p‑mTOR↓, 2,   NOTCH↓, 2,   P70S6K↓, 1,   p‑P70S6K↓, 1,   PI3K↓, 6,   PTEN↑, 2,   PTPN6↑, 1,   RAS↓, 1,   Src↑, 1,   STAT3↓, 7,   p‑STAT3↓, 1,   TumCG↓, 4,   Wnt↓, 4,  

Migration ⓘ

5LO↓, 1,   AntiAg↑, 2,   AP-1↓, 2,   DLC1↑, 1,   E-cadherin↑, 1,   EphB4↓, 1,   GnT-V↝, 1,   heparanase↝, 1,   ITGA5↓, 1,   Ki-67↓, 1,   MMP13↓, 1,   MMP2↓, 4,   MMP3↓, 1,   MMP7↓, 1,   MMP9↓, 4,   MUC4↓, 1,   N-cadherin↓, 2,   NM23↑, 1,   p‑p44↓, 1,   PKCδ↓, 1,   Rac1↓, 1,   Slug↓, 1,   Snail↓, 1,   TGF-β↓, 1,   TIMP1↑, 1,   TIMP2↑, 1,   TumCI↓, 1,   TumCMig↓, 1,   TumCP↓, 4,   TumMeta↓, 3,   Twist↓, 2,   VCAM-1↓, 1,   Vim↓, 2,   Zeb1↓, 1,   α-tubulin↓, 1,   β-catenin/ZEB1↓, 3,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 5,   EGFR↓, 1,   FLT4↓, 1,   Hif1a↓, 4,   KDR/FLK-1↓, 1,   NO↓, 1,   VEGF↓, 5,   VEGFR2↓, 1,  

Barriers & Transport ⓘ

NHE1↓, 1,   P-gp↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 5,   CXCL1↓, 1,   CXCR4↓, 4,   IL1↓, 1,   IL10↓, 1,   IL12↓, 1,   IL1β↓, 1,   IL2↑, 1,   IL6↓, 2,   Inflam↓, 4,   IκB↓, 1,   JAK↓, 1,   JAK2↓, 1,   NF-kB↓, 5,   NF-kB↑, 1,   p65↓, 1,   p‑p65↓, 1,   PGE2↓, 2,   TNF-α↓, 2,  

Cellular Microenvironment ⓘ

PLC↓, 1,  

Hormonal & Nuclear Receptors ⓘ

AR↓, 2,   CDK6↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 1,   BioAv↑, 2,   ChemoSen↑, 3,   Dose↝, 2,   eff↓, 3,   eff↑, 10,   Half-Life↓, 1,   Half-Life↝, 1,   RadioS↑, 2,   selectivity↑, 1,   TET2↑, 1,  

Clinical Biomarkers ⓘ

AR↓, 2,   EGFR↓, 1,   FOXM1↓, 2,   HEC1↓, 1,   HER2/EBBR2↓, 1,   IL6↓, 2,   Ki-67↓, 1,   Myc↓, 1,   NOS2↓, 1,  

Functional Outcomes ⓘ

AntiTum↑, 2,   chemoP↑, 3,   chemoPv↑, 1,   hepatoP↑, 1,   IMPDH1↓, 1,   IMPDH2↓, 1,   neuroP↑, 1,   radioP↑, 2,   toxicity∅, 1,   TumVol↓, 2,   TumW↓, 1,  
Total Targets: 237

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

GSTs↑, 1,   ROS↓, 2,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 3,   BioAv↝, 2,   Half-Life↝, 1,  

Functional Outcomes ⓘ

chemoPv↑, 1,  
Total Targets: 6

Scientific Paper Hit Count for: Mcl-1, myeloid cell leukemia 1
6 Citric Acid
6 Fisetin
4 Curcumin
3 Artemisinin
3 Baicalein
3 Phenethyl isothiocyanate
3 Quercetin
3 Silymarin (Milk Thistle) silibinin
2 3-bromopyruvate
2 Alpha-Lipoic-Acid
2 Apigenin (mainly Parsley)
2 Cisplatin
2 Chrysin
2 Garcinol
2 Honokiol
2 Luteolin
2 Resveratrol
2 Thymoquinone
1 Silver-NanoParticles
1 Sorafenib (brand name Nexavar)
1 Ashwagandha(Withaferin A)
1 Berberine
1 Betulinic acid
1 Bufalin/Huachansu
1 Docetaxel
1 methylseleninic acid
1 Ellagic acid
1 EGCG (Epigallocatechin Gallate)
1 Emodin
1 Fucoidan
1 Galloflavin
1 HydroxyTyrosol
1 Methylene blue
1 Photodynamic Therapy
1 Magnolol
1 Magnetic Fields
1 Chemotherapy
1 Mushroom Shiitake, AHCC
1 Naringin
1 Oleuropein
1 Piperlongumine
1 Sulforaphane (mainly Broccoli)
1 Shikonin
1 Aflavin-3,3′-digallate
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:182  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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